adalimumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
human origin 4904 331731-18-1

Description:

MoleculeDescription

Synonyms:

  • yuflym
  • ADALIMUMAB-ADBM
  • adalimumab-atto
  • amjevita
  • adalimumab
  • humira
  • adalimumab (genetical recombination)
  • LU200134
  • D2E7
A humanized monoclonal antibody that binds specifically to TNF-ALPHA and blocks its interaction with endogenous TNF RECEPTORS to modulate INFLAMMATION. It is used in the treatment of RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS; CROHN'S DISEASE and ULCERATIVE COLITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2.90 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 16, 2008 PMDA AbbVie GK
Sept. 8, 2003 EMA AbbVie Deutschland GmbH Co. KG
Dec. 31, 2002 FDA ABBVIE INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 9908.40 11.59 27298 596376 1017467 61847881
Therapy interrupted 3756.33 11.59 2868 620806 29587 62835761
Drug intolerance 3281.87 11.59 8465 615209 300196 62565152
Contraindicated product administered 2521.26 11.59 6171 617503 211477 62653871
Therapeutic product effect decreased 2420.99 11.59 5648 618026 187539 62677809
Treatment failure 2335.17 11.59 5672 618002 193371 62671977
Synovitis 2288.87 11.59 5416 618258 181502 62683846
Joint swelling 2137.88 11.59 7570 616104 320096 62545252
Arthropathy 1705.99 11.59 5626 618048 229166 62636182
Systemic lupus erythematosus 1648.26 11.59 5150 618524 203768 62661580
Toxicity to various agents 1598.37 11.59 257 623417 246993 62618355
Therapeutic product effect incomplete 1580.90 11.59 3671 620003 121385 62743963
Hypotension 1397.47 11.59 468 623206 272136 62593212
Arthralgia 1370.60 11.59 9921 613753 559789 62305559
Drug interaction 1363.52 11.59 293 623381 228838 62636510
Alopecia 1361.43 11.59 6733 616941 330803 62534545
Pemphigus 1343.86 11.59 4414 619260 179312 62686036
Completed suicide 1294.43 11.59 28 623646 145645 62719703
Acute kidney injury 1251.18 11.59 511 623163 262904 62602444
Psoriasis 1097.58 11.59 2552 621122 84405 62780943
Hand deformity 1093.02 11.59 3749 619925 155708 62709640
Glossodynia 1085.68 11.59 4041 619633 174835 62690513
Abdominal discomfort 1011.67 11.59 5986 617688 314899 62550449
Febrile neutropenia 1010.47 11.59 34 623640 118415 62746933
Swelling 928.21 11.59 5230 618444 270148 62595200
Pain 875.14 11.59 11097 612577 729531 62135817
Injection site pain 865.86 11.59 3025 620649 126775 62738573
Musculoskeletal stiffness 846.28 11.59 3825 619849 180793 62684555
Death 796.42 11.59 1545 622129 372836 62492512
Neutropenia 796.20 11.59 361 623313 174644 62690704
Rheumatoid arthritis 788.92 11.59 4719 618955 249100 62616248
C-reactive protein abnormal 781.71 11.59 1526 622148 44570 62820778
Dyspnoea 773.26 11.59 3608 620066 657705 62207643
Somnolence 738.93 11.59 418 623256 178267 62687081
Infection 732.75 11.59 4293 619381 224880 62640468
Wound 720.87 11.59 3346 620328 159917 62705431
Hyponatraemia 718.67 11.59 118 623556 111782 62753566
Rheumatoid factor positive 710.12 11.59 2130 621544 82276 62783072
Anaemia 705.26 11.59 1121 622553 292309 62573039
Thrombocytopenia 693.50 11.59 308 623366 150849 62714499
Anti-cyclic citrullinated peptide antibody positive 686.64 11.59 2604 621070 113608 62751740
Intentional overdose 667.56 11.59 12 623662 74140 62791208
Hepatic enzyme increased 665.40 11.59 3819 619855 198509 62666839
Drug abuse 664.42 11.59 9 623665 72509 62792839
Red blood cell sedimentation rate increased 629.96 11.59 1358 622316 42624 62822724
Constipation 623.29 11.59 776 622898 224167 62641181
Rash 598.00 11.59 8254 615420 552617 62312731
Malignant neoplasm progression 596.47 11.59 58 623616 82063 62783285
Overdose 567.65 11.59 210 623464 114868 62750480
Intestinal stenosis 555.80 11.59 349 623325 2535 62862813
Pericarditis 554.53 11.59 2661 621013 128918 62736430
Drug hypersensitivity 553.95 11.59 5061 618613 305626 62559722
Loss of personal independence in daily activities 536.26 11.59 2133 621541 95157 62770191
Platelet count decreased 531.95 11.59 237 623437 115885 62749463
Electrocardiogram QT prolonged 530.34 11.59 11 623663 59519 62805829
Lupus-like syndrome 518.43 11.59 694 622980 14601 62850747
Bradycardia 508.17 11.59 61 623613 73166 62792182
Psoriatic arthropathy 494.38 11.59 1994 621680 89526 62775822
Oxygen saturation decreased 489.70 11.59 132 623542 88453 62776895
Disease progression 480.90 11.59 306 623368 122452 62742896
Red blood cell sedimentation rate abnormal 479.27 11.59 766 622908 19016 62846332
Inflammation 478.74 11.59 1835 621839 80438 62784910
Discomfort 476.04 11.59 3043 620631 164331 62701017
Cardiac arrest 469.85 11.59 161 623513 92384 62772964
Diarrhoea 455.91 11.59 4664 619010 710702 62154646
Arthritis 454.59 11.59 2297 621377 113624 62751724
White blood cell count decreased 444.65 11.59 426 623248 138678 62726670
Asthenia 444.45 11.59 2097 621577 381507 62483841
Mobility decreased 441.35 11.59 2352 621322 118807 62746541
Tachycardia 438.06 11.59 313 623361 117843 62747505
Multiple sclerosis relapse 435.70 11.59 8 623666 48470 62816878
Pancytopenia 429.76 11.59 207 623467 96726 62768622
Product dose omission issue 429.67 11.59 1049 622625 233264 62632084
Bone erosion 427.79 11.59 685 622989 17032 62848316
Injection site reaction 423.27 11.59 1402 622272 57122 62808226
Tremor 421.48 11.59 406 623268 131833 62733515
Osteoarthritis 417.43 11.59 1950 621724 93393 62771955
Ileal stenosis 417.36 11.59 241 623433 1472 62863876
Fall 413.82 11.59 2216 621458 390118 62475230
Hypersensitivity 409.07 11.59 4535 619139 288150 62577198
C-reactive protein increased 406.59 11.59 1926 621748 92781 62772567
Agitation 402.02 11.59 55 623619 59702 62805646
Pustular psoriasis 401.89 11.59 346 623328 4280 62861068
Dehydration 400.43 11.59 679 622995 172675 62692673
Depressed level of consciousness 399.53 11.59 65 623609 62013 62803335
Adverse drug reaction 388.42 11.59 1683 621991 78031 62787317
Hypokalaemia 382.15 11.59 277 623397 103527 62761821
Dizziness 380.46 11.59 2567 621107 427358 62437990
Blood pressure increased 378.71 11.59 630 623044 161432 62703916
Seizure 374.03 11.59 451 623223 132183 62733165
Neutrophil count decreased 369.94 11.59 56 623618 56350 62808998
Anal fistula 369.76 11.59 295 623379 3256 62862092
Hyperkalaemia 369.14 11.59 48 623626 54155 62811193
Hypoglycaemia 358.49 11.59 76 623598 59989 62805359
Product use issue 356.56 11.59 3520 620154 217000 62648348
Hypoxia 356.15 11.59 76 623598 59716 62805632
Atrial fibrillation 353.52 11.59 374 623300 116262 62749086
Cardio-respiratory arrest 353.51 11.59 78 623596 59881 62805467
Sedation 350.44 11.59 6 623668 38803 62826545
Lactic acidosis 349.61 11.59 5 623669 38282 62827066
Joint stiffness 347.60 11.59 1052 622622 40817 62824531
Helicobacter infection 344.52 11.59 1811 621863 90974 62774374
Cognitive disorder 342.74 11.59 66 623608 55749 62809599
Knee arthroplasty 341.92 11.59 1241 622433 52965 62812383
International normalised ratio increased 336.53 11.59 33 623641 46392 62818956
Suicide attempt 330.63 11.59 94 623580 60824 62804524
Large intestinal stenosis 330.02 11.59 218 623456 1745 62863603
Metabolic acidosis 326.79 11.59 32 623642 45037 62820311
Duodenal ulcer perforation 325.04 11.59 1704 621970 85505 62779843
Respiratory failure 321.90 11.59 315 623359 101543 62763805
Coma 321.48 11.59 115 623559 64249 62801099
Therapy cessation 320.40 11.59 834 622840 29623 62835725
Hallucination 317.79 11.59 74 623600 54743 62810605
Neoplasm progression 315.80 11.59 9 623665 36419 62828929
Rhabdomyolysis 314.02 11.59 33 623641 43918 62821430
Heart rate increased 312.44 11.59 279 623395 93959 62771389
Maternal exposure during pregnancy 311.40 11.59 3419 620255 216643 62648705
Condition aggravated 309.94 11.59 5610 618064 396607 62468741
Injection site erythema 304.38 11.59 1617 622057 81557 62783791
Device expulsion 301.37 11.59 9 623665 34913 62830435
Chest discomfort 295.35 11.59 388 623286 109581 62755767
Intestinal obstruction 291.75 11.59 813 622861 30086 62835262
Vomiting 291.28 11.59 3814 619860 555803 62309545
Balance disorder 290.76 11.59 241 623433 84181 62781167
Injection site papule 290.54 11.59 147 623527 658 62864690
Neuropathy peripheral 286.31 11.59 420 623254 113247 62752101
Blood iron abnormal 277.61 11.59 260 623414 3616 62861732
Drug reaction with eosinophilia and systemic symptoms 274.12 11.59 14 623660 33822 62831526
Blood pressure decreased 271.60 11.59 150 623524 64872 62800476
Gastrointestinal haemorrhage 270.69 11.59 239 623435 80937 62784411
Hip arthroplasty 269.94 11.59 1054 622620 46592 62818756
Flushing 267.80 11.59 207 623467 74880 62790468
Nausea 266.05 11.59 6383 617291 848088 62017260
Cough 263.56 11.59 1738 621936 291005 62574343
Gastrointestinal inflammation 263.41 11.59 300 623374 5312 62860036
Serotonin syndrome 260.80 11.59 4 623670 28678 62836670
Encephalopathy 258.69 11.59 36 623638 38584 62826764
Haemoglobin decreased 252.81 11.59 669 623005 144816 62720532
Renal failure 251.69 11.59 483 623191 117169 62748179
Hyperglycaemia 249.78 11.59 53 623621 41814 62823534
Cardiac failure congestive 246.29 11.59 328 623346 92105 62773243
Abdominal adhesions 238.64 11.59 219 623455 2963 62862385
Orthostatic hypotension 236.88 11.59 36 623638 36124 62829224
Syncope 233.15 11.59 503 623171 116882 62748466
Rheumatoid nodule 227.81 11.59 514 623160 16641 62848707
Renal impairment 226.89 11.59 322 623352 88033 62777315
Tuberculin test positive 225.89 11.59 222 623452 3289 62862059
Epistaxis 223.92 11.59 230 623444 72495 62792853
Anxiety 221.08 11.59 1243 622431 216298 62649050
Injection site haemorrhage 220.98 11.59 631 623043 23683 62841665
Foot deformity 217.38 11.59 685 622989 27168 62838180
Confusional state 216.40 11.59 1396 622278 234984 62630364
Injection site urticaria 215.89 11.59 447 623227 13626 62851722
Drug specific antibody present 215.89 11.59 237 623437 4022 62861326
Heart rate decreased 214.91 11.59 89 623585 45471 62819877
Decreased appetite 214.20 11.59 1514 622160 249538 62615810
Mental status changes 211.39 11.59 63 623611 39536 62825812
Respiratory arrest 210.45 11.59 34 623640 32611 62832737
Fistula 209.86 11.59 371 623303 10022 62855326
Muscle spasms 209.68 11.59 806 622868 155344 62710004
Blood pressure systolic increased 208.83 11.59 102 623572 47295 62818053
Injection site pruritus 208.65 11.59 938 622736 44178 62821170
Drug withdrawal syndrome 206.14 11.59 16 623658 27178 62838170
Blood bilirubin increased 202.10 11.59 57 623617 37083 62828265
Palmar-plantar erythrodysaesthesia syndrome 202.07 11.59 5 623669 23010 62842338
Hypervolaemia 198.75 11.59 23 623651 28390 62836958
Agranulocytosis 195.67 11.59 13 623661 25121 62840227
Plasma cell myeloma 195.57 11.59 55 623619 35850 62829498
Impaired healing 193.73 11.59 1693 621981 100849 62764499
Mucosal inflammation 193.47 11.59 110 623564 46818 62818530
Deep vein thrombosis 192.65 11.59 329 623345 83471 62781877
Joint range of motion decreased 192.39 11.59 728 622946 31700 62833648
Uveitis 191.72 11.59 398 623276 12155 62853193
Pneumonia aspiration 191.72 11.59 51 623623 34489 62830859
Insomnia 191.55 11.59 1282 622392 213970 62651378
Peripheral swelling 191.48 11.59 3672 620002 262270 62603078
Cardiac failure 190.60 11.59 366 623308 88776 62776572
Hypomagnesaemia 189.64 11.59 28 623646 28709 62836639
Surgery 189.45 11.59 777 622897 35135 62830213
Dysphagia 189.16 11.59 364 623310 88221 62777127
Unresponsive to stimuli 187.57 11.59 50 623624 33766 62831582
Toxic epidermal necrolysis 186.29 11.59 17 623657 25317 62840031
Intentional product misuse 186.02 11.59 194 623480 60723 62804625
Lethargy 185.39 11.59 166 623508 55841 62809507
Blood glucose increased 184.26 11.59 338 623336 83418 62781930
Intentional self-injury 184.24 11.59 19 623655 25668 62839680
Pulmonary arterial hypertension 183.98 11.59 9 623665 22568 62842780
Multiple organ dysfunction syndrome 183.35 11.59 172 623502 56580 62808768
Blood pressure fluctuation 183.30 11.59 114 623560 46203 62819145
Dyspnoea exertional 183.06 11.59 193 623481 60109 62805239
Pyoderma gangrenosum 182.50 11.59 201 623473 3424 62861924
Pulmonary oedema 181.20 11.59 163 623511 54710 62810638
Rheumatic fever 180.01 11.59 870 622804 42241 62823107
Chest pain 178.05 11.59 1315 622359 214644 62650704
Hidradenitis 177.62 11.59 177 623497 2669 62862679
Tuberculosis 175.40 11.59 359 623315 10852 62854496
Disorientation 175.19 11.59 84 623590 39368 62825980
Osteonecrosis of jaw 174.96 11.59 63 623611 35060 62830288
Gastrooesophageal reflux disease 174.42 11.59 429 623245 95210 62770138
Blood creatinine increased 173.93 11.59 377 623297 87467 62777881
Intestinal fistula 172.77 11.59 109 623565 799 62864549
Pulmonary embolism 170.03 11.59 582 623092 116102 62749246
Oedema peripheral 168.93 11.59 1128 622546 188383 62676965
Full blood count abnormal 168.32 11.59 51 623623 31666 62833682
Musculoskeletal disorder 167.84 11.59 515 623159 20129 62845219
Finger deformity 167.51 11.59 285 623389 7460 62857888
Deformity 167.49 11.59 361 623313 11323 62854025
Therapy non-responder 167.44 11.59 1298 622376 74603 62790745
Fluid retention 167.06 11.59 204 623470 59482 62805866
Drug specific antibody 166.80 11.59 157 623517 2198 62863150
Dyskinesia 165.30 11.59 54 623620 31948 62833400
Infusion related reaction 165.25 11.59 3356 620318 242165 62623183
Tenosynovitis 164.22 11.59 396 623278 13399 62851949
Demyelination 163.56 11.59 265 623409 6655 62858693
Hepatic function abnormal 163.53 11.59 80 623594 37062 62828286
Ankylosing spondylitis 163.39 11.59 335 623339 10139 62855209
Acute respiratory failure 163.24 11.59 67 623607 34418 62830930
Liver function test increased 161.45 11.59 695 622979 32116 62833232
Full blood count decreased 161.41 11.59 30 623644 25994 62839354
Product quality issue 161.35 11.59 75 623599 35790 62829558
Disability 158.88 11.59 468 623206 17879 62847469
Pleural effusion 157.81 11.59 434 623240 92776 62772572
Abscess 157.76 11.59 439 623235 16229 62849119
Pulmonary hypertension 157.41 11.59 84 623590 37039 62828309
Suicidal ideation 156.79 11.59 231 623443 62190 62803158
Dysgeusia 156.33 11.59 137 623537 46573 62818775
Panniculitis 155.52 11.59 345 623329 11040 62854308
Drug delivery system malfunction 154.81 11.59 111 623563 1029 62864319
Pulmonary fibrosis 154.59 11.59 787 622887 39022 62826326
Intestinal resection 154.02 11.59 164 623510 2684 62862664
Disturbance in attention 151.11 11.59 94 623580 38095 62827253
Injection site irritation 150.83 11.59 214 623460 4764 62860584
Small intestinal obstruction 150.53 11.59 459 623215 17878 62847470
Frequent bowel movements 150.18 11.59 533 623141 22489 62842859
Restlessness 149.85 11.59 51 623623 29402 62835946
Dysarthria 149.43 11.59 120 623554 42591 62822757
Melaena 148.66 11.59 56 623618 30309 62835039
Gastrointestinal disorder 148.14 11.59 1954 621720 129285 62736063
Cholestasis 147.97 11.59 52 623622 29382 62835966
Palpitations 147.57 11.59 588 623086 112182 62753166
Abscess intestinal 146.91 11.59 124 623550 1490 62863858
Incorrect dose administered 146.13 11.59 1050 622624 58918 62806430
Basal cell carcinoma 145.57 11.59 603 623071 27388 62837960
Fibromyalgia 144.79 11.59 1314 622360 79106 62786242
Joint effusion 144.72 11.59 432 623242 16628 62848720
Myalgia 144.60 11.59 845 622829 145684 62719664
Lymphocyte count decreased 144.50 11.59 58 623616 30199 62835149
Altered state of consciousness 144.37 11.59 35 623639 25195 62840153
Aggression 143.80 11.59 28 623646 23470 62841878
Blood cholesterol increased 143.53 11.59 1484 622190 92548 62772800
Injection site swelling 143.15 11.59 878 622796 46694 62818654
Colectomy 142.59 11.59 151 623523 2455 62862893
Adverse reaction 142.56 11.59 312 623362 9891 62855457
Arthrodesis 142.21 11.59 156 623518 2645 62862703
Muscle spasticity 142.06 11.59 22 623652 21772 62843576
Swollen joint count increased 140.16 11.59 713 622961 35341 62830007
Blood pressure diastolic decreased 139.07 11.59 27 623647 22679 62842669
Injection site rash 138.97 11.59 454 623220 18355 62846993
Sepsis 138.14 11.59 908 622766 152215 62713133
Joint destruction 137.78 11.59 232 623442 6020 62859328
Asthma 137.70 11.59 714 622960 126847 62738501
Haematoma 137.37 11.59 86 623588 34734 62830614
Hyperhidrosis 136.87 11.59 569 623105 107267 62758081
Hallucination, visual 136.54 11.59 15 623659 19283 62846065
Anal stenosis 135.68 11.59 73 623601 380 62864968
Acute hepatic failure 135.56 11.59 12 623662 18315 62847033
Musculoskeletal pain 135.05 11.59 1444 622230 90833 62774515
Obstructive airways disorder 134.68 11.59 21 623653 20678 62844670
Joint injury 133.12 11.59 610 623064 28962 62836386
Dermatitis psoriasiform 132.77 11.59 136 623538 2123 62863225
Bone pain 132.61 11.59 207 623467 54434 62810914
Bone marrow failure 132.15 11.59 61 623613 29229 62836119
Small intestinal stenosis 131.68 11.59 78 623596 503 62864845
Deafness transitory 131.30 11.59 127 623547 1843 62863505
Status epilepticus 131.17 11.59 4 623670 15229 62850119
Respiratory distress 131.00 11.59 86 623588 33865 62831483
Hepatic failure 130.06 11.59 96 623578 35560 62829788
Psychotic disorder 129.99 11.59 45 623629 25667 62839681
Folliculitis 129.68 11.59 1155 622519 69162 62796186
Myelosuppression 129.67 11.59 36 623638 23667 62841681
Granuloma skin 129.43 11.59 268 623406 8169 62857179
Nasal congestion 128.97 11.59 283 623391 65377 62799971
Accidental overdose 128.26 11.59 35 623639 23274 62842074
Dermatitis allergic 127.94 11.59 383 623291 14765 62850583
Withdrawal syndrome 126.30 11.59 22 623652 19975 62845373
Blood parathyroid hormone decreased 126.27 11.59 290 623384 9501 62855847
Nodule 125.52 11.59 473 623201 20553 62844795
Infusion site pain 124.89 11.59 11 623663 16858 62848490
Fear of injection 124.83 11.59 240 623434 6924 62858424
Malignant melanoma 124.62 11.59 316 623358 11040 62854308
Grip strength decreased 124.56 11.59 491 623183 21796 62843552
Feeling abnormal 124.44 11.59 899 622775 147493 62717855
Blood alkaline phosphatase increased 124.37 11.59 143 623531 42824 62822524
Ventricular tachycardia 123.97 11.59 23 623651 19956 62845392
Inappropriate antidiuretic hormone secretion 123.37 11.59 7 623667 15455 62849893
Neurotoxicity 123.33 11.59 12 623662 16978 62848370
Blood creatine phosphokinase increased 121.65 11.59 74 623600 30356 62834992
Intestinal fibrosis 121.12 11.59 49 623625 111 62865237
Enthesopathy 121.02 11.59 264 623410 8350 62856998
Ileostomy 121.00 11.59 107 623567 1375 62863973
Pruritus allergic 120.82 11.59 110 623564 1472 62863876
Joint dislocation 120.70 11.59 433 623241 18367 62846981
Premature delivery 120.55 11.59 74 623600 30207 62835141
Memory impairment 120.31 11.59 570 623104 103688 62761660
Drug level increased 119.85 11.59 37 623637 22699 62842649
Paradoxical psoriasis 118.32 11.59 54 623620 182 62865166
Neutropenic sepsis 118.30 11.59 12 623662 16426 62848922
Shoulder arthroplasty 118.25 11.59 170 623504 3832 62861516
Hepatocellular injury 117.50 11.59 61 623613 27320 62838028
Drug tolerance decreased 116.09 11.59 407 623267 17066 62848282
Sinus bradycardia 114.84 11.59 7 623667 14544 62850804
Ejection fraction decreased 114.78 11.59 38 623636 22294 62843054
Blood pressure diastolic abnormal 114.76 11.59 7 623667 14535 62850813
Haematemesis 114.70 11.59 79 623595 30333 62835015
Diabetic ketoacidosis 114.32 11.59 30 623644 20475 62844873
Herpes zoster 113.57 11.59 1275 622399 81187 62784161
Surgical failure 113.05 11.59 86 623588 880 62864468
Body temperature increased 111.79 11.59 120 623554 37072 62828276
Generalised tonic-clonic seizure 111.28 11.59 74 623600 28942 62836406
Irritable bowel syndrome 110.69 11.59 1268 622406 81144 62784204
Right ventricular failure 110.57 11.59 18 623656 17170 62848178
Anal abscess 110.31 11.59 178 623496 4454 62860894
Respiratory depression 110.07 11.59 6 623668 13709 62851639
Adverse event 109.70 11.59 1080 622594 66479 62798869
Angioedema 109.59 11.59 189 623485 47776 62817572
Shock 108.78 11.59 47 623627 23416 62841932
Intentional dose omission 108.39 11.59 243 623431 7832 62857516
Arrhythmia 108.17 11.59 129 623545 38011 62827337
Stevens-Johnson syndrome 107.94 11.59 55 623619 24895 62840453
Labelled drug-drug interaction medication error 107.11 11.59 6 623668 13393 62851955
Blood calcium decreased 106.19 11.59 64 623610 26387 62838961
Abnormal behaviour 105.75 11.59 39 623635 21387 62843961
Gamma-glutamyltransferase increased 105.45 11.59 107 623567 33924 62831424
Tachypnoea 105.07 11.59 21 623653 17281 62848067
Skin ulcer 104.46 11.59 753 622921 42292 62823056
Upper gastrointestinal haemorrhage 104.31 11.59 28 623646 18824 62846524
Delirium 104.14 11.59 212 623462 50329 62815019
Blood pressure systolic abnormal 103.98 11.59 7 623667 13379 62851969
Respiratory rate increased 103.53 11.59 8 623666 13640 62851708
Product use in unapproved indication 103.49 11.59 1192 622482 177888 62687460
Sinus tachycardia 101.30 11.59 56 623618 24212 62841136
Irritability 101.26 11.59 97 623577 31597 62833751
Myoclonus 101.22 11.59 17 623657 15851 62849497
Metastases to bone 100.85 11.59 40 623634 20979 62844369
Extrapyramidal disorder 100.17 11.59 8 623666 13276 62852072
No adverse event 99.39 11.59 158 623516 41247 62824101
Faecal calprotectin increased 98.98 11.59 139 623535 3064 62862284
Furuncle 98.89 11.59 207 623467 6359 62858989
Weight decreased 98.84 11.59 2021 621653 274777 62590571
Coagulopathy 98.73 11.59 39 623635 20505 62844843
Circulatory collapse 98.49 11.59 46 623628 21892 62843456
Productive cough 98.47 11.59 306 623368 62902 62802446
Acute myocardial infarction 98.40 11.59 102 623572 32022 62833326
Dysphonia 97.87 11.59 200 623474 47414 62817934
Muscle injury 97.67 11.59 1027 622647 64318 62801030
Speech disorder 97.56 11.59 155 623519 40474 62824874
Impaired work ability 96.86 11.59 384 623290 17091 62848257
Gastrointestinal wall thickening 96.39 11.59 92 623582 1312 62864036
Vision blurred 96.13 11.59 520 623154 91404 62773944
Haemorrhage intracranial 96.04 11.59 10 623664 13409 62851939
Sleep disorder due to general medical condition, insomnia type 95.91 11.59 857 622817 51360 62813988
Ascites 95.34 11.59 158 623516 40570 62824778
Musculoskeletal deformity 94.63 11.59 105 623569 1804 62863544
Subdural haematoma 94.45 11.59 14 623660 14314 62851034
Hyperlipidaemia 94.30 11.59 37 623637 19534 62845814
Jaundice 94.06 11.59 89 623585 29162 62836186
Contrast media allergy 93.97 11.59 117 623557 2284 62863064
Disseminated intravascular coagulation 93.48 11.59 35 623639 19016 62846332
Urinary retention 93.06 11.59 96 623578 30205 62835143
Cerebral haemorrhage 92.52 11.59 99 623575 30630 62834718
Paternal drugs affecting foetus 91.93 11.59 31 623643 30 62865318
Polyarthritis 91.88 11.59 263 623411 9883 62855465
Posterior reversible encephalopathy syndrome 91.84 11.59 28 623646 17317 62848031
Poisoning 91.21 11.59 13 623661 13687 62851661
Palmoplantar pustulosis 91.20 11.59 59 623615 454 62864894
Synovial cyst 91.17 11.59 267 623407 10166 62855182
Infusion site erythema 91.03 11.59 6 623668 11673 62853675
Ulcer 91.00 11.59 501 623173 25606 62839742
Inflammatory bowel disease 90.99 11.59 150 623524 3823 62861525
Disseminated tuberculosis 90.95 11.59 126 623548 2741 62862607
Hyperbilirubinaemia 90.64 11.59 5 623669 11309 62854039
Rectal stenosis 90.57 11.59 44 623630 177 62865171
Mycobacterium tuberculosis complex test positive 90.21 11.59 111 623563 2140 62863208
Product administration error 90.18 11.59 54 623620 22343 62843005
Gastrointestinal stenosis 89.60 11.59 42 623632 153 62865195
Intestinal mucosal hypertrophy 89.21 11.59 46 623628 216 62865132
Inappropriate schedule of product administration 89.00 11.59 626 623048 103339 62762009
Urinary incontinence 88.97 11.59 110 623564 31904 62833444
Allergic oedema 88.81 11.59 70 623604 758 62864590
Pulmonary toxicity 88.47 11.59 248 623426 9207 62856141
Antinuclear antibody positive 88.20 11.59 223 623451 7776 62857572
Throat irritation 88.17 11.59 146 623528 37501 62827847
Pancreatitis acute 88.13 11.59 82 623592 27084 62838264
Urinary tract infection 87.66 11.59 1956 621718 262728 62602620
Inflammatory marker increased 87.57 11.59 202 623472 6637 62858711
Blood urea increased 87.51 11.59 78 623596 26301 62839047
Live birth 86.77 11.59 488 623186 25142 62840206
Hypothermia 85.64 11.59 15 623659 13566 62851782
Chronic kidney disease 85.63 11.59 200 623474 45198 62820150
Weight increased 85.58 11.59 1930 621744 258862 62606486
Dystonia 85.55 11.59 16 623658 13803 62851545
Cerebrovascular accident 85.51 11.59 665 623009 107359 62757989
Gastrointestinal pain 85.24 11.59 250 623424 9526 62855822
Gastrointestinal fistula 85.14 11.59 55 623619 422 62864926
Osteoporosis 84.68 11.59 899 622775 56439 62808909
Chills 84.67 11.59 709 622965 112669 62752679
Cardiogenic shock 84.61 11.59 35 623639 17897 62847451
Guttate psoriasis 84.59 11.59 54 623620 405 62864943
Anhedonia 84.48 11.59 6 623668 10968 62854380
Foot operation 84.38 11.59 206 623468 7025 62858323
Electrolyte imbalance 84.27 11.59 46 623628 20030 62845318
Cervical dysplasia 84.15 11.59 129 623545 3085 62862263
Gastrointestinal scarring 84.11 11.59 49 623625 305 62865043
Mania 84.07 11.59 11 623663 12356 62852992
Illness 83.95 11.59 793 622881 48266 62817082
Medication error 83.66 11.59 250 623424 52034 62813314
Intestinal anastomosis complication 83.48 11.59 44 623630 218 62865130
Skin necrosis 83.42 11.59 314 623360 13636 62851712
Delusion 83.37 11.59 10 623664 12007 62853341
Body height below normal 83.24 11.59 105 623569 2078 62863270
Pyrexia 82.95 11.59 3777 619897 466701 62398647
Sacroiliitis 82.86 11.59 129 623545 3128 62862220
Blood potassium increased 82.80 11.59 38 623636 18271 62847077
Type 2 diabetes mellitus 82.33 11.59 975 622699 62893 62802455
Tooth disorder 82.26 11.59 93 623581 28064 62837284
Intestinal anastomosis 81.70 11.59 53 623621 410 62864938
Dactylitis 81.68 11.59 114 623560 2498 62862850
Blister 81.51 11.59 1757 621917 128057 62737291
Rheumatoid lung 81.12 11.59 140 623534 3708 62861640
Limb deformity 80.98 11.59 143 623531 3859 62861489
Blood lactate dehydrogenase increased 80.79 11.59 65 623609 23051 62842297
Parkinsonism 79.52 11.59 6 623668 10433 62854915
Blood sodium decreased 78.91 11.59 73 623601 24179 62841169
Oral mucosal exfoliation 78.61 11.59 89 623585 1565 62863783
Pallor 77.85 11.59 112 623562 30456 62834892
Drug eruption 77.31 11.59 515 623159 28179 62837169
Rhinorrhoea 76.53 11.59 357 623317 65220 62800128
Fistula discharge 75.75 11.59 72 623602 1021 62864327
Presyncope 75.62 11.59 97 623577 27688 62837660
Emotional distress 75.51 11.59 127 623547 32422 62832926
Metastases to central nervous system 75.33 11.59 18 623656 13087 62852261
Pneumonia 74.72 11.59 3696 619978 453071 62412277
Alanine aminotransferase increased 74.32 11.59 656 623018 103114 62762234
Gastrointestinal obstruction 74.19 11.59 71 623603 1016 62864332
Back pain 74.10 11.59 2001 621673 262144 62603204
Infusion site extravasation 74.03 11.59 8 623666 10418 62854930
Mydriasis 73.68 11.59 14 623660 11942 62853406
Nervousness 73.61 11.59 119 623555 30860 62834488
Muscular weakness 73.57 11.59 807 622867 121546 62743802
Infusion site swelling 73.35 11.59 6 623668 9764 62855584
Blood glucose decreased 73.12 11.59 59 623615 20893 62844455
Wheezing 73.10 11.59 594 623080 95001 62770347
Hallucination, auditory 72.96 11.59 18 623656 12806 62852542
Hypocalcaemia 72.41 11.59 125 623549 31588 62833760
Sleep apnoea syndrome 71.99 11.59 109 623565 29024 62836324
Aphasia 71.82 11.59 134 623540 32866 62832482
Skin plaque 71.81 11.59 212 623462 8108 62857240
Joint arthroplasty 71.75 11.59 110 623564 2631 62862717
Muscle twitching 71.67 11.59 53 623621 19615 62845733
Physical disability 71.53 11.59 110 623564 2638 62862710
Fine motor skill dysfunction 71.37 11.59 151 623523 4674 62860674
Transfusion 71.31 11.59 30 623644 15187 62850161
Ill-defined disorder 71.21 11.59 1164 622510 80591 62784757
Anastomotic stenosis 71.18 11.59 41 623633 249 62865099
Antinuclear antibody increased 71.13 11.59 76 623598 1249 62864099
Abdominal abscess 70.88 11.59 145 623529 4381 62860967
Renal disorder 70.79 11.59 135 623539 32839 62832509
Tardive dyskinesia 70.54 11.59 3 623671 8499 62856849
Pericardial effusion 69.99 11.59 117 623557 29941 62835407
Body temperature decreased 69.94 11.59 58 623616 20261 62845087
Lymphopenia 69.93 11.59 47 623627 18280 62847068
Hypophosphataemia 69.11 11.59 14 623660 11412 62853936
Cardiac disorder 68.98 11.59 261 623413 50555 62814793
Bronchitis chronic 68.81 11.59 140 623534 4213 62861135
Cholecystitis chronic 68.58 11.59 10 623664 10351 62854997
Female genital tract fistula 68.51 11.59 196 623478 7363 62857985
Diarrhoea haemorrhagic 68.37 11.59 220 623454 8822 62856526
Human antichimeric antibody positive 67.85 11.59 84 623590 1630 62863718
Acidosis 67.45 11.59 14 623660 11219 62854129
Acute respiratory distress syndrome 67.37 11.59 79 623595 23455 62841893
Device issue 67.22 11.59 432 623242 23349 62841999
Seasonal allergy 67.06 11.59 64 623610 20886 62844462
Nightmare 67.04 11.59 54 623620 19140 62846208
Endometriosis 66.87 11.59 156 623518 5164 62860184
Shock haemorrhagic 66.79 11.59 9 623665 9886 62855462
Ataxia 66.47 11.59 33 623641 15162 62850186
Foetal death 66.36 11.59 248 623426 10732 62854616
Acute generalised exanthematous pustulosis 66.30 11.59 14 623660 11085 62854263
Injection site hypersensitivity 66.28 11.59 92 623582 2005 62863343
Muscle rigidity 65.70 11.59 16 623658 11484 62853864
Coronary artery disease 65.69 11.59 137 623537 32240 62833108
Chronic obstructive pulmonary disease 65.31 11.59 355 623319 62331 62803017
Hospice care 65.15 11.59 3 623671 7929 62857419
Red blood cell sedimentation rate 65.07 11.59 146 623528 4708 62860640
Device defective 64.92 11.59 88 623586 1874 62863474
Coordination abnormal 64.79 11.59 27 623647 13746 62851602
Hypovolaemia 64.71 11.59 13 623661 10660 62854688
Off label use 64.68 11.59 5726 617948 668736 62196612
Joint laxity 64.66 11.59 99 623575 2365 62862983
Cytopenia 64.62 11.59 17 623657 11584 62853764
Sleep disorder due to a general medical condition 63.95 11.59 20 623654 12168 62853180
X-ray abnormal 63.77 11.59 200 623474 7910 62857438
Injection site warmth 63.67 11.59 307 623367 14888 62850460
Fracture 63.66 11.59 59 623615 19525 62845823
Immunodeficiency 63.58 11.59 378 623296 19876 62845472
Paranoia 63.40 11.59 18 623656 11661 62853687
Haemodialysis 63.18 11.59 7 623667 8940 62856408
Blood potassium decreased 62.97 11.59 207 623467 41819 62823529
Epicondylitis 62.88 11.59 92 623582 2108 62863240
Sciatica 62.85 11.59 563 623111 33761 62831587
Device dislocation 62.73 11.59 97 623577 25608 62839740
Hepatic cytolysis 62.24 11.59 37 623637 15370 62849978
Hepatic encephalopathy 61.96 11.59 17 623657 11265 62854083
Hot flush 61.79 11.59 275 623399 50884 62814464
Mental impairment 61.50 11.59 31 623643 14120 62851228
Liver injury 61.28 11.59 884 622790 59636 62805712
Pulseless electrical activity 61.27 11.59 3 623671 7518 62857830
Metastases to liver 60.81 11.59 86 623588 23553 62841795
Feeling cold 60.37 11.59 88 623586 23800 62841548
Aspartate aminotransferase increased 59.77 11.59 582 623092 89695 62775653
Miosis 59.69 11.59 3 623671 7350 62857998
Pneumonitis 59.59 11.59 164 623510 35058 62830290
Abnormal dreams 59.36 11.59 15 623659 10501 62854847
Papilloma viral infection 59.05 11.59 75 623599 1495 62863853
Dialysis 58.62 11.59 15 623659 10412 62854936
Chromaturia 58.43 11.59 47 623627 16670 62848678
Heart rate irregular 58.24 11.59 81 623593 22340 62843008
Renal tubular necrosis 57.98 11.59 22 623652 11856 62853492
Pain in extremity 57.80 11.59 3887 619787 327599 62537749
Cerebral infarction 57.50 11.59 91 623583 23802 62841546
Oliguria 57.50 11.59 10 623664 9091 62856257
Bronchospasm 57.43 11.59 51 623623 17229 62848119
Eosinophilia 57.34 11.59 84 623590 22672 62842676
Product complaint 57.28 11.59 27 623647 12782 62852566
Blood pressure systolic decreased 57.07 11.59 4 623670 7393 62857955
Pollakiuria 56.86 11.59 118 623556 27819 62837529
Rhinitis allergic 56.78 11.59 22 623652 11705 62853643
Salivary hypersecretion 56.75 11.59 5 623669 7661 62857687
Rash pustular 56.73 11.59 179 623495 7103 62858245
Bacteraemia 56.70 11.59 52 623622 17296 62848052
Gastrointestinal stoma complication 56.58 11.59 80 623594 1775 62863573
Investigation abnormal 56.14 11.59 82 623592 1876 62863472
Diabetes mellitus inadequate control 56.11 11.59 40 623634 15086 62850262
Spinal column injury 56.08 11.59 84 623590 1967 62863381
Dysuria 55.66 11.59 159 623515 33579 62831769
Progressive multifocal leukoencephalopathy 55.50 11.59 29 623645 12942 62852406
Prothrombin time prolonged 55.24 11.59 13 623661 9551 62855797
Transient ischaemic attack 55.16 11.59 188 623486 37565 62827783
Intestinal dilatation 55.11 11.59 76 623598 1646 62863702
Angina pectoris 54.74 11.59 135 623539 29943 62835405
Arthritis enteropathic 54.66 11.59 35 623639 264 62865084
Enterocutaneous fistula 54.55 11.59 68 623606 1329 62864019
Wheelchair user 54.53 11.59 161 623513 6158 62859190
Ear infection 54.49 11.59 595 623079 37618 62827730
Depressed mood 54.18 11.59 207 623467 39984 62825364
Graft versus host disease 54.15 11.59 3 623671 6760 62858588
Urine output decreased 53.95 11.59 22 623652 11348 62854000
Cyanosis 53.90 11.59 52 623622 16883 62848465
Gait inability 53.79 11.59 774 622900 52185 62813163
Haemorrhage 53.41 11.59 365 623309 60657 62804691
Complication of device insertion 53.21 11.59 6 623668 7558 62857790
Cytomegalovirus infection 53.13 11.59 77 623597 20875 62844473
Accidental exposure to product 53.08 11.59 119 623555 27286 62838062
Schizophrenia 52.81 11.59 16 623658 9936 62855412
Device related infection 52.68 11.59 93 623581 23299 62842049
Toxic encephalopathy 52.42 11.59 3 623671 6576 62858772
Hip fracture 52.32 11.59 134 623540 29340 62836008
Atrioventricular block complete 52.28 11.59 9 623665 8242 62857106
Depression 52.11 11.59 1500 622174 194992 62670356
Haemodynamic instability 52.09 11.59 13 623661 9177 62856171
Onychomycosis 52.03 11.59 184 623490 7748 62857600
Cutaneous T-cell lymphoma 52.02 11.59 66 623608 1314 62864034
Intervertebral disc protrusion 52 11.59 405 623269 23304 62842044
Dry skin 51.93 11.59 336 623338 56551 62808797
Tonsillar ulcer 51.79 11.59 34 623640 269 62865079
Dementia 51.78 11.59 65 623609 18729 62846619
Injection site haematoma 51.45 11.59 166 623508 6666 62858682
Colitis ulcerative 51.44 11.59 435 623239 25656 62839692
Restless legs syndrome 51.15 11.59 64 623610 18467 62846881
Fistula of small intestine 50.91 11.59 37 623637 351 62864997
Lymphoma 50.90 11.59 246 623428 11941 62853407
Leukopenia 50.86 11.59 499 623175 76791 62788557
Haemoptysis 50.68 11.59 131 623543 28595 62836753
Head injury 50.62 11.59 122 623552 27274 62838074
Bradyphrenia 50.48 11.59 5 623669 6975 62858373
Limb operation 50.45 11.59 118 623556 3913 62861435
Adhesion 50.44 11.59 62 623612 1194 62864154
Pouchitis 50.41 11.59 41 623633 466 62864882
Double stranded DNA antibody positive 50.20 11.59 35 623639 309 62865039
Ovarian neoplasm 50.13 11.59 53 623621 860 62864488
Cutaneous vasculitis 50.08 11.59 139 623535 5130 62860218
Cartilage atrophy 49.66 11.59 27 623647 144 62865204
Loose body in joint 49.27 11.59 62 623612 1224 62864124
Incorrect product administration duration 49.13 11.59 26 623648 11520 62853828
Injection site bruising 48.91 11.59 628 623046 41282 62824066
Rheumatic disorder 48.80 11.59 99 623575 2973 62862375
Headache 48.59 11.59 5463 618211 627778 62237570
Haemolysis 48.55 11.59 5 623669 6763 62858585
Feeling hot 47.72 11.59 294 623380 50060 62815288
C-reactive protein decreased 47.61 11.59 53 623621 914 62864434
Ileal ulcer 47.55 11.59 39 623635 449 62864899
Complication associated with device 47.53 11.59 58 623616 16920 62848428
Hypothyroidism 47.46 11.59 236 623438 42396 62822952
Red cell distribution width decreased 47.34 11.59 78 623596 1987 62863361
Disease susceptibility 47.34 11.59 28 623646 180 62865168
Infusion site pruritus 47.34 11.59 3 623671 6032 62859316
Vascular access complication 47.21 11.59 79 623595 2039 62863309
COVID-19 pneumonia 47.15 11.59 42 623632 14167 62851181
Synovectomy 47.01 11.59 27 623647 163 62865185
Renal injury 46.89 11.59 17 623657 9422 62855926
Therapeutic response decreased 46.73 11.59 857 622817 60668 62804680
Blood lactic acid increased 46.53 11.59 7 623667 7079 62858269
Scleritis 46.30 11.59 121 623553 4307 62861041
Atrial flutter 46.22 11.59 19 623655 9753 62855595
Bloody discharge 45.99 11.59 66 623608 1485 62863863
Spinal stenosis 45.86 11.59 277 623397 14648 62850700
Respiratory acidosis 45.58 11.59 6 623668 6709 62858639
Nephropathy toxic 45.54 11.59 18 623656 9461 62855887
Neck pain 45.36 11.59 944 622730 68374 62796974
Postoperative adhesion 45.17 11.59 34 623640 342 62865006
Immunosuppression 45.13 11.59 189 623485 8625 62856723
Lower gastrointestinal haemorrhage 45.03 11.59 11 623663 7879 62857469
Transplant rejection 44.81 11.59 25 623649 10755 62854593
Haematuria 44.80 11.59 142 623532 29015 62836333
Exostosis 44.80 11.59 315 623359 17547 62847801
Ankle operation 44.53 11.59 59 623615 1228 62864120
Rectal discharge 44.51 11.59 43 623631 623 62864725
Eosinophil count increased 44.49 11.59 26 623648 10902 62854446
Injury associated with device 44.45 11.59 106 623568 3560 62861788
Precancerous cells present 44.35 11.59 63 623611 1404 62863944
Haemolytic anaemia 44.27 11.59 22 623652 10103 62855245
Cardiac failure acute 44.27 11.59 19 623655 9504 62855844
Bone density decreased 44.14 11.59 270 623404 14342 62851006
Vascular device infection 44.14 11.59 9 623665 7303 62858045
Rales 44.00 11.59 36 623638 12661 62852687
Ileostomy closure 43.97 11.59 28 623646 209 62865139
Psychomotor hyperactivity 43.94 11.59 25 623649 10638 62854710
Antibody test positive 43.91 11.59 88 623586 2619 62862729
Pneumonia viral 43.84 11.59 174 623500 7748 62857600
Musculoskeletal chest pain 43.80 11.59 88 623586 20995 62844353
Cytomegalovirus viraemia 43.74 11.59 3 623671 5646 62859702
Stress cardiomyopathy 43.70 11.59 19 623655 9431 62855917
Abdominal pain upper 43.56 11.59 1623 622051 204821 62660527
Brain oedema 43.56 11.59 45 623629 14150 62851198
Premature baby 43.55 11.59 86 623588 20649 62844699
Personality change 43.32 11.59 8 623666 6965 62858383
Pain in jaw 43.31 11.59 250 623424 43246 62822102
Rectal abscess 43.14 11.59 58 623616 1225 62864123
Glomerular filtration rate decreased 43.09 11.59 41 623633 13400 62851948
Parapsoriasis 43.05 11.59 22 623652 101 62865247
Wrist deformity 42.96 11.59 76 623598 2054 62863294
Dermatitis bullous 42.82 11.59 15 623659 8493 62856855
Nasopharyngitis 42.79 11.59 2973 620701 251284 62614064
Petechiae 42.70 11.59 44 623630 13853 62851495
Pulmonary mass 42.59 11.59 373 623301 22223 62843125
Sensitivity to weather change 42.53 11.59 162 623512 7075 62858273
Personality disorder 42.45 11.59 4 623670 5807 62859541
Product preparation error 42.44 11.59 5 623669 6087 62859261
Mean platelet volume decreased 42.38 11.59 86 623588 2583 62862765
Tinnitus 42.13 11.59 193 623481 35435 62829913
Eye disorder 42.00 11.59 373 623301 22312 62843036
Increased appetite 42.00 11.59 21 623653 9609 62855739
Blood pressure diastolic increased 41.92 11.59 23 623651 9987 62855361
Cholangitis sclerosing 41.75 11.59 65 623609 1576 62863772
Sickle cell anaemia with crisis 41.63 11.59 5 623669 5998 62859350
Skin reaction 41.51 11.59 269 623405 14580 62850768
Ileectomy 41.51 11.59 24 623650 147 62865201
Small intestinal resection 41.31 11.59 36 623638 453 62864895
Rash maculo-papular 41.26 11.59 167 623507 31729 62833619
Anticipatory anxiety 41.22 11.59 56 623618 1195 62864153
Neoplasm malignant 41.22 11.59 462 623212 29399 62835949
Gastrointestinal oedema 41.19 11.59 56 623618 1196 62864152
Postoperative wound infection 41.02 11.59 214 623460 10711 62854637
Body height decreased 41.00 11.59 24 623650 10054 62855294
Clostridium difficile colitis 40.92 11.59 88 623586 20481 62844867
Osteoporotic fracture 40.85 11.59 104 623570 3642 62861706
Pulmonary tuberculosis 40.82 11.59 117 623557 4400 62860948
Ear pain 40.75 11.59 199 623475 35919 62829429
Hypokinesia 40.74 11.59 46 623628 13890 62851458
Anuria 40.57 11.59 38 623636 12513 62852835
Bronchopulmonary aspergillosis 40.50 11.59 17 623657 8618 62856730
Breast cancer 40.33 11.59 684 622990 47699 62817649
Coeliac disease 40.28 11.59 239 623435 12558 62852790
Pelvic pain 40.20 11.59 44 623630 13475 62851873
Oedema 39.95 11.59 696 622978 96926 62768422
Proctitis 39.89 11.59 131 623543 5310 62860038
Nocturia 39.87 11.59 15 623659 8126 62857222
Adjustment disorder with depressed mood 39.79 11.59 202 623472 10002 62855346
International normalised ratio fluctuation 39.53 11.59 80 623594 2398 62862950
Ventricular fibrillation 39.47 11.59 35 623639 11832 62853516
Ageusia 39.39 11.59 46 623628 13682 62851666
Hypotonia 39.37 11.59 21 623653 9264 62856084
Myocardial infarction 39.36 11.59 717 622957 99176 62766172
Enterocolitis 39.29 11.59 14 623660 7844 62857504
Blood thyroid stimulating hormone increased 39.21 11.59 11 623663 7183 62858165
Ecchymosis 39.01 11.59 31 623643 11063 62854285
Apnoea 38.92 11.59 15 623659 8007 62857341
Retinal toxicity 38.91 11.59 55 623619 1220 62864128
Colonic fistula 38.84 11.59 28 623646 262 62865086
Acute myeloid leukaemia 38.77 11.59 68 623606 17079 62848269
Hereditary angioedema 38.63 11.59 13 623661 7549 62857799
Apathy 38.62 11.59 19 623655 8775 62856573
Genital haemorrhage 38.52 11.59 12 623662 7320 62858028
Atypical femur fracture 38.45 11.59 4 623670 5368 62859980
Colitis 38.27 11.59 680 622994 47848 62817500
Ankle arthroplasty 38.27 11.59 66 623608 1747 62863601
Septic shock 38.25 11.59 444 623230 66185 62799163
Oropharyngeal pain 38.24 11.59 675 622999 93812 62771536
Thirst 38.23 11.59 49 623625 13992 62851356
Atrioventricular block first degree 38.04 11.59 12 623662 7261 62858087
Product label confusion 38.03 11.59 66 623608 1756 62863592
Neuralgia 37.95 11.59 129 623545 25797 62839551
Sinusitis 37.74 11.59 2648 621026 224005 62641343
Metabolic encephalopathy 37.55 11.59 6 623668 5803 62859545
Anorectal disorder 37.35 11.59 64 623610 1685 62863663
Loss of consciousness 37.32 11.59 879 622795 117242 62748106
Aspiration 37.31 11.59 31 623643 10820 62854528
Oesophagitis 37.23 11.59 56 623618 14952 62850396
Hypertriglyceridaemia 37.17 11.59 8 623666 6251 62859097
Abortion spontaneous 37.10 11.59 661 623013 46534 62818814
Injection site vesicles 37.10 11.59 87 623587 2890 62862458
Taste disorder 36.86 11.59 48 623626 13614 62851734
Bradykinesia 36.79 11.59 4 623670 5184 62860164
Acute pulmonary oedema 36.78 11.59 17 623657 8141 62857207
Pseudopolyp 36.74 11.59 27 623647 261 62865087
Amyotrophic lateral sclerosis 36.73 11.59 51 623623 1112 62864236
Polyuria 36.69 11.59 19 623655 8523 62856825
Defaecation urgency 36.62 11.59 107 623567 4068 62861280
Incisional hernia 36.55 11.59 61 623613 1571 62863777
Hypercapnia 36.52 11.59 5 623669 5426 62859922
Fear 36.12 11.59 62 623612 15704 62849644
Intestinal perforation 36.11 11.59 221 623453 11742 62853606
Epilepsy 36.09 11.59 140 623534 26925 62838423
Post procedural sepsis 36.04 11.59 24 623650 195 62865153
General symptom 36.02 11.59 83 623591 2725 62862623
Atrioventricular block 35.96 11.59 15 623659 7632 62857716
Substance abuse 35.95 11.59 3 623671 4804 62860544
Tonsillitis 35.89 11.59 131 623543 5604 62859744
Subarachnoid haemorrhage 35.72 11.59 53 623621 14230 62851118
Lymphadenopathy 35.52 11.59 553 623121 37905 62827443
Subileus 35.44 11.59 89 623585 3090 62862258
Leukocytosis 35.33 11.59 133 623541 25802 62839546
Upper-airway cough syndrome 35.26 11.59 36 623638 11382 62853966
Gastroenteritis 35.17 11.59 138 623536 26452 62838896
Skin toxicity 35.10 11.59 3 623671 4711 62860637
Pulmonary congestion 35.08 11.59 74 623600 17344 62848004
Paradoxical drug reaction 35.08 11.59 105 623569 4047 62861301
Retinitis 35.02 11.59 137 623537 6059 62859289
Intestinal operation 35.01 11.59 34 623640 496 62864852
Myopathy 34.88 11.59 35 623639 11156 62854192
Amnesia 34.86 11.59 363 623311 55222 62810126
Wrist surgery 34.83 11.59 43 623631 832 62864516
Cholecystitis 34.75 11.59 61 623613 15316 62850032
Postoperative abscess 34.70 11.59 31 623643 404 62864944
Pharyngitis 34.65 11.59 326 623348 19817 62845531
Affect lability 34.61 11.59 35 623639 11116 62854232
Procedural intestinal perforation 34.53 11.59 21 623653 143 62865205
Iritis 34.47 11.59 88 623586 3087 62862261
Proctocolectomy 34.38 11.59 15 623659 44 62865304
Face oedema 34.27 11.59 94 623580 20118 62845230
Granulocytopenia 34.20 11.59 7 623667 5665 62859683
Neck mass 34.20 11.59 95 623579 3508 62861840
Latent tuberculosis 34.08 11.59 78 623596 2549 62862799
Coma scale abnormal 34.05 11.59 5 623669 5148 62860200
Heparin-induced thrombocytopenia 33.89 11.59 3 623671 4579 62860769
Accident 33.79 11.59 133 623541 5899 62859449
Product prescribing error 33.78 11.59 138 623536 26151 62839197
Hypersomnia 33.68 11.59 80 623594 17975 62847373
Anaphylactic shock 33.64 11.59 119 623555 23514 62841834
Product administration interrupted 33.61 11.59 4 623670 4832 62860516
Troponin increased 33.48 11.59 30 623644 10091 62855257
Injection site nodule 33.37 11.59 98 623576 3737 62861611
Intestinal ulcer 33.30 11.59 54 623620 1357 62863991
Product monitoring error 33.28 11.59 3 623671 4513 62860835
Activated partial thromboplastin time prolonged 33.26 11.59 13 623661 6880 62858468
Neuroendocrine carcinoma of the skin 33.24 11.59 35 623639 565 62864783
Secretion discharge 33.23 11.59 220 623454 12011 62853337
Lipase increased 33.17 11.59 29 623645 9871 62855477
Post transplant lymphoproliferative disorder 32.97 11.59 5 623669 5026 62860322
Catatonia 32.93 11.59 3 623671 4474 62860874
Dry mouth 32.87 11.59 552 623122 77311 62788037
Erythema nodosum 32.77 11.59 114 623560 4761 62860587
Injection site oedema 32.71 11.59 54 623620 1378 62863970
Hemiparesis 32.63 11.59 118 623556 23164 62842184
Gastrointestinal mucosa hyperaemia 32.52 11.59 22 623652 184 62865164
Acute graft versus host disease 32.48 11.59 3 623671 4425 62860923
Rash pruritic 32.42 11.59 793 622881 59006 62806342
Bronchitis 32.28 11.59 957 622717 123978 62741370
Retching 32.28 11.59 59 623615 14586 62850762
Meniscus injury 32.20 11.59 147 623527 6967 62858381
Drug level abnormal 32.14 11.59 19 623655 122 62865226
Pharyngitis streptococcal 32.11 11.59 197 623477 10475 62854873
Osteonecrosis 32 11.59 128 623546 24402 62840946
Skin lesion 31.99 11.59 451 623223 30270 62835078
Jaundice cholestatic 31.90 11.59 16 623658 7308 62858040
Pneumonia legionella 31.85 11.59 58 623616 1604 62863744
Blood loss anaemia 31.84 11.59 25 623649 8976 62856372
Post procedural infection 31.70 11.59 178 623496 9164 62856184
Angina unstable 31.66 11.59 15 623659 7080 62858268
Functional gastrointestinal disorder 31.64 11.59 103 623571 4156 62861192
Breast cancer stage I 31.62 11.59 14 623660 6875 62858473
Blood creatine increased 31.60 11.59 8 623666 5593 62859755
Ventricular extrasystoles 31.59 11.59 41 623633 11646 62853702
Histone antibody positive 31.56 11.59 16 623658 72 62865276
Hepatitis cholestatic 31.53 11.59 14 623660 6864 62858484
Lymph node tuberculosis 31.37 11.59 39 623635 760 62864588
Stupor 31.08 11.59 3 623671 4272 62861076
Drug level decreased 31.05 11.59 157 623517 7762 62857586
Ocular sarcoidosis 30.94 11.59 14 623660 46 62865302
Intestinal mass 30.75 11.59 42 623632 901 62864447
Electrocardiogram abnormal 30.61 11.59 27 623647 9152 62856196
Blood calcium increased 30.59 11.59 28 623646 9322 62856026
Aspergillus infection 30.55 11.59 21 623653 8072 62857276
Laryngeal disorder 30.40 11.59 44 623630 998 62864350
Blood culture positive 30.36 11.59 5 623669 4730 62860618
Erythema multiforme 30.35 11.59 33 623641 10136 62855212
Inflammatory pain 30.32 11.59 41 623633 871 62864477
Blood pressure inadequately controlled 30.31 11.59 6 623668 4972 62860376
Brain natriuretic peptide increased 30.28 11.59 7 623667 5206 62860142
Myocarditis 30.27 11.59 34 623640 10291 62855057
Faecal calprotectin abnormal 30.24 11.59 16 623658 80 62865268
Post procedural complication 30.21 11.59 278 623396 16796 62848552
Supraventricular tachycardia 30.13 11.59 59 623615 14212 62851136
Ischaemic stroke 30.08 11.59 84 623590 17873 62847475
Eye pruritus 30.06 11.59 89 623585 18582 62846766
Tubulointerstitial nephritis 29.84 11.59 98 623576 19805 62845543
Cutaneous leishmaniasis 29.78 11.59 16 623658 83 62865265
Hypovolaemic shock 29.74 11.59 12 623662 6229 62859119
Peptic ulcer haemorrhage 29.57 11.59 44 623630 1024 62864324
Ketoacidosis 29.51 11.59 4 623670 4374 62860974
Depressive symptom 29.50 11.59 3 623671 4099 62861249
Device occlusion 29.47 11.59 18 623656 7369 62857979
Anger 29.45 11.59 48 623626 12408 62852940
Somnambulism 29.25 11.59 9 623665 5534 62859814
Vertigo 29.21 11.59 413 623261 59474 62805874
Large intestinal obstruction 29.15 11.59 68 623606 2251 62863097
Cholelithiasis 29.14 11.59 283 623391 43642 62821706
Multiple fractures 29.11 11.59 164 623510 8454 62856894
Initial insomnia 29.08 11.59 12 623662 6145 62859203
Infected dermal cyst 29.06 11.59 29 623645 438 62864910
Hepatitis acute 29.03 11.59 28 623646 9092 62856256
Hyperreflexia 28.95 11.59 11 623663 5923 62859425
Obesity 28.94 11.59 434 623240 29518 62835830
Bursitis 28.84 11.59 518 623156 36523 62828825
Ectopic pregnancy 28.76 11.59 72 623602 2495 62862853
Tricuspid valve incompetence 28.72 11.59 63 623611 14558 62850790
Vasculitic rash 28.71 11.59 50 623624 1334 62864014
Infusion site reaction 28.70 11.59 89 623585 3498 62861850
Lip swelling 28.59 11.59 183 623491 30880 62834468
Disturbance in social behaviour 28.51 11.59 3 623671 3990 62861358
Lower respiratory tract infection viral 28.51 11.59 40 623634 881 62864467
Metastases to lung 28.43 11.59 51 623623 12699 62852649
Hypernatraemia 28.38 11.59 20 623654 7589 62857759
Limb injury 28.38 11.59 141 623533 25336 62840012
Cytomegalovirus infection reactivation 28.24 11.59 3 623671 3960 62861388
Incorrect drug administration rate 28.23 11.59 3 623671 3959 62861389
Malignant melanoma in situ 28.14 11.59 40 623634 892 62864456
Intra-abdominal fluid collection 28.13 11.59 69 623605 2360 62862988
Atelectasis 28.09 11.59 112 623562 21371 62843977
Large intestinal ulcer 28.07 11.59 86 623588 3358 62861990
Azotaemia 28.06 11.59 5 623669 4466 62860882
Lyme disease 27.99 11.59 86 623588 3363 62861985
Enterovesical fistula 27.97 11.59 31 623643 532 62864816
Poor quality sleep 27.96 11.59 101 623573 19834 62845514
Head discomfort 27.86 11.59 56 623618 13359 62851989
IgA nephropathy 27.82 11.59 32 623642 573 62864775
Nail disorder 27.81 11.59 221 623453 12794 62852554
Sneezing 27.80 11.59 89 623585 18129 62847219
Vaginal fistula 27.80 11.59 28 623646 428 62864920
Catheter site infection 27.76 11.59 7 623667 4907 62860441
Dry throat 27.67 11.59 16 623658 6749 62858599
Bile acid malabsorption 27.60 11.59 19 623655 164 62865184
Colon dysplasia 27.59 11.59 15 623659 80 62865268
Systemic infection 27.59 11.59 6 623668 4654 62860694
Low birth weight baby 27.58 11.59 18 623656 7111 62858237
Atrial septal defect 27.55 11.59 17 623657 6921 62858427
Blood chloride decreased 27.50 11.59 10 623664 5532 62859816
Iridocyclitis 27.48 11.59 70 623604 2452 62862896
Cardiomyopathy 27.47 11.59 85 623589 17499 62847849
Gait disturbance 27.41 11.59 2122 621552 181056 62684292
Psychomotor retardation 27.40 11.59 3 623671 3867 62861481
DNA antibody positive 27.37 11.59 25 623649 336 62865012
Lacrimation increased 27.33 11.59 107 623567 20524 62844824
Anti-cyclic citrullinated peptide antibody 27.21 11.59 135 623539 6623 62858725
Eye irritation 27.20 11.59 117 623557 21854 62843494
Thrombotic thrombocytopenic purpura 27.09 11.59 3 623671 3833 62861515
Food intolerance 27.07 11.59 83 623591 3242 62862106
Short-bowel syndrome 27.03 11.59 29 623645 479 62864869
Blood glucose fluctuation 26.87 11.59 6 623668 4570 62860778
Non-cardiac chest pain 26.87 11.59 14 623660 6258 62859090
Injection site inflammation 26.82 11.59 91 623583 3752 62861596
Drug ineffective for unapproved indication 26.79 11.59 210 623464 33853 62831495
Concomitant disease aggravated 26.72 11.59 30 623644 9082 62856266
Enterostomy 26.69 11.59 19 623655 174 62865174
Spondyloarthropathy 26.68 11.59 38 623636 849 62864499
Onychomadesis 26.67 11.59 121 623553 5719 62859629
Partial seizures 26.61 11.59 12 623662 5830 62859518
Visual acuity reduced 26.55 11.59 117 623557 21709 62843639
Throat tightness 26.44 11.59 140 623534 24747 62840601
Colostomy 26.39 11.59 39 623635 902 62864446
Serum ferritin decreased 26.35 11.59 61 623613 2009 62863339
Infiltration anaesthesia 26.34 11.59 19 623655 178 62865170
Kidney transplant rejection 26.32 11.59 5 623669 4266 62861082
Haematocrit decreased 26.29 11.59 253 623421 39087 62826261
Hunger 26.19 11.59 10 623664 5369 62859979
Exposure to communicable disease 26.19 11.59 31 623643 573 62864775
Pulse absent 26.16 11.59 10 623664 5364 62859984
Device difficult to use 26.08 11.59 54 623620 12742 62852606
Atrial tachycardia 26.05 11.59 5 623669 4235 62861113
Product residue present 25.97 11.59 4 623670 3975 62861373
Tonsillar hypertrophy 25.96 11.59 40 623634 961 62864387
Flatulence 25.89 11.59 217 623457 34485 62830863
Product dose omission in error 25.86 11.59 22 623652 7590 62857758
Allergic respiratory symptom 25.81 11.59 18 623656 159 62865189
Neutrophil count increased 25.74 11.59 80 623594 16447 62848901
Brain herniation 25.66 11.59 3 623671 3674 62861674
Lip ulceration 25.64 11.59 60 623614 1990 62863358
Hypoacusis 25.58 11.59 136 623538 24015 62841333
Clonus 25.43 11.59 7 623667 4629 62860719
Dermatitis atopic 25.39 11.59 35 623639 9689 62855659
Choking 25.35 11.59 36 623638 9843 62855505
Gastritis 25.31 11.59 239 623435 37064 62828284
Granuloma 25.30 11.59 118 623556 5643 62859705
Local reaction 25.30 11.59 33 623641 676 62864672
Mental disorder 25.26 11.59 150 623524 25769 62839579
Injection site extravasation 25.23 11.59 161 623513 8680 62856668
Thrombosis 25.12 11.59 466 623208 64289 62801059
Drug level above therapeutic 25.00 11.59 8 623666 4797 62860551
Dyshidrotic eczema 24.98 11.59 31 623643 603 62864745
Torus fracture 24.95 11.59 17 623657 144 62865204
Pulmonary arterial pressure increased 24.92 11.59 3 623671 3592 62861756
Diffuse vasculitis 24.91 11.59 10 623664 22 62865326
Loss of therapeutic response 24.79 11.59 31 623643 608 62864740
Dermal cyst 24.75 11.59 54 623620 1708 62863640
Macular degeneration 24.64 11.59 356 623318 24020 62841328
Incontinence 24.64 11.59 48 623626 11584 62853764
Back injury 24.60 11.59 171 623503 9489 62855859
Amylase increased 24.57 11.59 16 623658 6329 62859019
Aphonia 24.53 11.59 38 623636 10025 62855323
Faeces discoloured 24.51 11.59 96 623578 18413 62846935
Obsessive-compulsive disorder 24.50 11.59 5 623669 4055 62861293
COVID-19 24.47 11.59 1352 622322 111751 62753597
Stenosis 24.47 11.59 48 623626 1406 62863942
Red blood cell count decreased 24.45 11.59 268 623406 40377 62824971
Spondylitis 24.39 11.59 96 623578 4258 62861090
Blood triglycerides increased 24.37 11.59 54 623620 12434 62852914
Neck deformity 24.30 11.59 60 623614 2061 62863287
Mucous stools 24.07 11.59 94 623580 4154 62861194
Compression fracture 23.98 11.59 17 623657 6431 62858917
Euphoric mood 23.94 11.59 9 623665 4878 62860470
Hypoalbuminaemia 23.91 11.59 50 623624 11755 62853593
Prolonged labour 23.89 11.59 29 623645 551 62864797
Application site pruritus 23.85 11.59 5 623669 3979 62861369
Diplopia 23.82 11.59 136 623538 23592 62841756
Ammonia increased 23.79 11.59 8 623666 4648 62860700
Proctectomy 23.77 11.59 15 623659 110 62865238
Rectal cancer 23.62 11.59 60 623614 2098 62863250
Device malfunction 23.62 11.59 274 623400 17583 62847765
Cold sweat 23.58 11.59 52 623622 11995 62853353
Steroid dependence 23.58 11.59 53 623621 1711 62863637
Abscess rupture 23.55 11.59 21 623653 273 62865075
Postoperative wound complication 23.54 11.59 38 623636 951 62864397
Application site erythema 23.53 11.59 9 623665 4826 62860522
Rib fracture 23.52 11.59 128 623546 22469 62842879
Gastric disorder 23.50 11.59 506 623168 36863 62828485
Subcutaneous abscess 23.40 11.59 113 623561 5483 62859865
Purulent discharge 23.39 11.59 100 623574 4606 62860742
Asphyxia 23.38 11.59 16 623658 6165 62859183
Mean cell volume decreased 23.34 11.59 89 623585 3889 62861459
Pseudopolyposis 23.32 11.59 9 623665 17 62865331
Galactorrhoea 23.31 11.59 6 623668 4149 62861199
Genital abscess 23.31 11.59 21 623653 277 62865071
Electroencephalogram abnormal 23.28 11.59 4 623670 3668 62861680
Drug resistance 23.27 11.59 131 623543 22802 62842546
Atrioventricular block second degree 23.25 11.59 5 623669 3909 62861439
Sudden death 23.12 11.59 42 623632 10407 62854941
Tension headache 23.08 11.59 11 623663 5175 62860173
Device use error 23.04 11.59 14 623660 5747 62859601
Respiratory syncytial virus infection 22.98 11.59 21 623653 6997 62858351
Gangrene 22.96 11.59 16 623658 6107 62859241
Drug screen positive 22.90 11.59 4 623670 3625 62861723
B-cell lymphoma 22.84 11.59 78 623596 3227 62862121
Middle insomnia 22.81 11.59 57 623617 12586 62852762
Benign hepatic neoplasm 22.70 11.59 13 623661 78 62865270
Squamous cell carcinoma 22.69 11.59 154 623520 8478 62856870
Obliterative bronchiolitis 22.68 11.59 58 623616 2037 62863311
Intestinal polyp 22.66 11.59 48 623626 1487 62863861
Autoimmune pancreatitis 22.55 11.59 20 623654 258 62865090
Joint warmth 22.53 11.59 47 623627 1440 62863908
Abdominal lymphadenopathy 22.53 11.59 32 623642 713 62864635
Ventricular arrhythmia 22.52 11.59 5 623669 3823 62861525
Aplastic anaemia 22.50 11.59 37 623637 9532 62855816
Post procedural inflammation 22.50 11.59 11 623663 45 62865303
Refusal of treatment by patient 22.49 11.59 13 623661 5484 62859864
Rotator cuff syndrome 22.47 11.59 217 623457 13285 62852063
Nasal polyps 22.36 11.59 16 623658 6023 62859325
Skin laceration 22.35 11.59 131 623543 22577 62842771
Small intestine operation 22.29 11.59 10 623664 32 62865316
Peritonitis bacterial 22.26 11.59 10 623664 4869 62860479
Influenza 22.19 11.59 858 622816 107864 62757484
Blood phosphorus decreased 22.15 11.59 8 623666 4445 62860903
Caesarean section 22.14 11.59 89 623585 16943 62848405
Gastrointestinal anastomotic leak 22.10 11.59 18 623656 205 62865143
Therapeutic response unexpected 21.95 11.59 102 623572 18657 62846691
Hyperthermia 21.91 11.59 35 623639 9121 62856227
Bone marrow oedema 21.88 11.59 42 623632 1210 62864138
Failure to thrive 21.88 11.59 23 623651 7175 62858173
Crohn's disease 21.85 11.59 101 623573 4812 62860536
Metabolic disorder 21.84 11.59 19 623655 6484 62858864
Micturition urgency 21.83 11.59 38 623636 9573 62855775
Wrong product administered 21.80 11.59 17 623657 6124 62859224
Toxic skin eruption 21.79 11.59 60 623614 12825 62852523
Enterococcal infection 21.77 11.59 27 623647 7821 62857527
Deafness 21.77 11.59 271 623403 17686 62847662
Gastrointestinal infection 21.73 11.59 161 623513 9120 62856228
Panic reaction 21.63 11.59 7 623667 4167 62861181
Pyoderma 21.60 11.59 22 623652 341 62865007
Foetal exposure during pregnancy 21.59 11.59 205 623469 31757 62833591
Cancer pain 21.43 11.59 3 623671 3202 62862146
Anastomotic ulcer 21.43 11.59 23 623651 380 62864968
Mammoplasty 21.42 11.59 27 623647 534 62864814
Spinal operation 21.41 11.59 147 623527 8124 62857224
Sexual dysfunction 21.40 11.59 8 623666 4351 62860997
Epigastric discomfort 21.37 11.59 21 623653 6759 62858589
Prosthesis user 21.36 11.59 12 623662 69 62865279
Perirectal abscess 21.34 11.59 35 623639 888 62864460
Peripheral sensory neuropathy 21.34 11.59 25 623649 7426 62857922
Cerebral haematoma 21.29 11.59 5 623669 3678 62861670
Mean cell haemoglobin decreased 21.24 11.59 104 623570 5075 62860273
Ventricular hypertrophy 21.22 11.59 4 623670 3432 62861916
Thyroid neoplasm 21.22 11.59 87 623587 3932 62861416
Device deployment issue 21.21 11.59 6 623668 3896 62861452
Muscle haemorrhage 21.20 11.59 3 623671 3176 62862172
Catheter site haemorrhage 21.17 11.59 3 623671 3172 62862176
Ear injury 21.06 11.59 17 623657 191 62865157
Groin abscess 21.06 11.59 36 623638 946 62864402
Computerised tomogram abdomen abnormal 20.98 11.59 9 623665 25 62865323
Embolism venous 20.98 11.59 3 623671 3151 62862197
Volvulus 20.97 11.59 51 623623 1735 62863613
Amenorrhoea 20.92 11.59 41 623633 9873 62855475
Hydronephrosis 20.89 11.59 46 623628 10616 62854732
Juvenile idiopathic arthritis 20.83 11.59 76 623598 3250 62862098
Thinking abnormal 20.79 11.59 46 623628 10597 62854751
Abortion incomplete 20.78 11.59 3 623671 3128 62862220
Blood immunoglobulin E increased 20.77 11.59 6 623668 3843 62861505
Glycosylated haemoglobin increased 20.77 11.59 58 623616 12340 62853008
Histoplasmosis 20.75 11.59 54 623620 1917 62863431
Anaplastic large-cell lymphoma 20.64 11.59 13 623661 95 62865253
Pulmonary alveolar haemorrhage 20.63 11.59 10 623664 4658 62860690
Ligament sprain 20.62 11.59 61 623613 12739 62852609
Intestinal sepsis 20.58 11.59 20 623654 292 62865056
Patent ductus arteriosus 20.53 11.59 8 623666 4242 62861106
Endophthalmitis 20.52 11.59 5 623669 3587 62861761
Brachiocephalic artery stenosis 20.48 11.59 9 623665 27 62865321
Thyroiditis subacute 20.41 11.59 19 623655 262 62865086
Urine leukocyte esterase positive 20.41 11.59 5 623669 3574 62861774
Muscle strain 20.40 11.59 31 623643 8243 62857105
Hernia 20.39 11.59 201 623473 12373 62852975
Hypertonia 20.39 11.59 10 623664 4627 62860721
Breast cancer stage III 20.39 11.59 173 623501 10213 62855135
Immune thrombocytopenia 20.31 11.59 46 623628 10510 62854838
Optic neuritis 20.14 11.59 147 623527 8288 62857060
Therapeutic product effect variable 20.13 11.59 40 623634 1183 62864165
Autoimmune haemolytic anaemia 20.11 11.59 10 623664 4591 62860757
Effusion 20.11 11.59 49 623625 1669 62863679
Pneumonia bacterial 20.10 11.59 39 623635 9426 62855922
Nail psoriasis 20.08 11.59 28 623646 613 62864735
Respiratory rate decreased 20.04 11.59 5 623669 3530 62861818
Hepatic cirrhosis 20.00 11.59 348 623326 24386 62840962
Demyelinating polyneuropathy 19.93 11.59 31 623643 751 62864597
Eyelid oedema 19.89 11.59 46 623628 10433 62854915
Arthritis bacterial 19.89 11.59 120 623554 6343 62859005
Hepatic necrosis 19.86 11.59 16 623658 5671 62859677
Stridor 19.83 11.59 5 623669 3505 62861843
Dizziness postural 19.81 11.59 26 623648 7350 62857998
Magnetic resonance imaging thoracic abnormal 19.81 11.59 8 623666 18 62865330
Unwanted pregnancy 19.75 11.59 11 623663 62 62865286
Soft tissue disorder 19.74 11.59 91 623583 4331 62861017
Intestinal fistula infection 19.73 11.59 7 623667 9 62865339
Autoantibody positive 19.72 11.59 10 623664 45 62865303
Chronic recurrent multifocal osteomyelitis 19.72 11.59 10 623664 45 62865303
End stage renal disease 19.66 11.59 22 623652 6671 62858677
Unevaluable event 19.66 11.59 652 623022 50734 62814614
Sputum discoloured 19.66 11.59 88 623586 16259 62849089
Tendonitis 19.64 11.59 286 623388 19329 62846019
Parakeratosis 19.63 11.59 19 623655 276 62865072
Cutaneous sarcoidosis 19.61 11.59 21 623653 346 62865002
Tumour marker increased 19.58 11.59 12 623662 4903 62860445
Breast cancer metastatic 19.56 11.59 57 623617 11961 62853387
Genital cyst 19.55 11.59 10 623664 46 62865302
Thrombosis in device 19.53 11.59 3 623671 2987 62862361
Anal fissure 19.51 11.59 91 623583 4352 62860996
Drug tolerance 19.49 11.59 126 623548 6823 62858525
Left ventricular dysfunction 19.41 11.59 57 623617 11931 62853417
Intestinal ischaemia 19.38 11.59 27 623647 7441 62857907
Performance status decreased 19.36 11.59 6 623668 3672 62861676
Post-traumatic stress disorder 19.33 11.59 14 623660 5237 62860111
Sinus node dysfunction 19.28 11.59 11 623663 4674 62860674
Escherichia bacteraemia 19.28 11.59 7 623667 3876 62861472
SAPHO syndrome 19.13 11.59 12 623662 87 62865261
Pseudomonas infection 19.12 11.59 52 623622 11161 62854187
Hypertransaminasaemia 19.12 11.59 22 623652 6587 62858761
Polyneuropathy 19.11 11.59 76 623598 14513 62850835
Congestive hepatopathy 19.11 11.59 3 623671 2939 62862409
Haemophagocytic lymphohistiocytosis 19.10 11.59 48 623626 10579 62854769
Henoch-Schonlein purpura 19.09 11.59 38 623636 1125 62864223
Ileocolectomy 19.06 11.59 10 623664 49 62865299
Ventricular hypokinesia 18.97 11.59 11 623663 4633 62860715
Cholelithiasis obstructive 18.97 11.59 8 623666 21 62865327
Muscle tightness 18.96 11.59 57 623617 11843 62853505
Enterocolonic fistula 18.95 11.59 9 623665 34 62865314
Metastasis 18.94 11.59 14 623660 5183 62860165
Diffuse alopecia 18.88 11.59 33 623641 883 62864465
Laboratory test abnormal 18.87 11.59 171 623503 26741 62838607
Adenocarcinoma of the cervix 18.84 11.59 16 623658 194 62865154
Intercepted product prescribing error 18.84 11.59 16 623658 194 62865154
Bundle branch block right 18.82 11.59 13 623661 4985 62860363
Heavy exposure to ultraviolet light 18.80 11.59 12 623662 90 62865258
Acute coronary syndrome 18.78 11.59 45 623629 10081 62855267
Mitral valve incompetence 18.77 11.59 114 623560 19480 62845868
Parinaud syndrome 18.77 11.59 6 623668 4 62865344
Toothache 18.76 11.59 111 623563 19088 62846260
Extremity contracture 18.76 11.59 40 623634 1245 62864103
Vulval disorder 18.74 11.59 32 623642 840 62864508
Weight fluctuation 18.72 11.59 43 623631 9776 62855572
Catheterisation cardiac 18.67 11.59 11 623663 4592 62860756
Neutrophil count abnormal 18.67 11.59 3 623671 2889 62862459
Diabetic eye disease 18.66 11.59 14 623660 140 62865208
Spinal cord infection 18.65 11.59 28 623646 657 62864691
Cartilage injury 18.64 11.59 52 623622 1925 62863423
Lymphoedema 18.63 11.59 56 623618 11636 62853712
Alopecia areata 18.60 11.59 47 623627 1638 62863710
Supraventricular extrasystoles 18.56 11.59 11 623663 4578 62860770
Exercise tolerance decreased 18.54 11.59 16 623658 5481 62859867
Embolic stroke 18.42 11.59 7 623667 3769 62861579
Ventricular septal defect 18.42 11.59 10 623664 4368 62860980
Maternal exposure timing unspecified 18.37 11.59 126 623548 6961 62858387
Antibiotic therapy 18.29 11.59 36 623638 1057 62864291
Duodenal ulcer 18.23 11.59 30 623644 7726 62857622
Diastolic dysfunction 18.23 11.59 22 623652 6449 62858899
Myxoid liposarcoma 18.21 11.59 6 623668 5 62865343
Lichen myxoedematosus 18.21 11.59 8 623666 24 62865324
Disease risk factor 18.20 11.59 11 623663 74 62865274
Haemorrhagic stroke 18.18 11.59 18 623656 5774 62859574
Infection transmission via personal contact 18.16 11.59 5 623669 0 62865348
Gastrointestinal anastomotic stenosis 18.16 11.59 5 623669 0 62865348
Pulmonary function test decreased 18.15 11.59 8 623666 3939 62861409
Pruritus 18.12 11.59 3199 620475 358254 62507094
Rhinovirus infection 18.12 11.59 11 623663 4518 62860830
Stress at work 18.12 11.59 38 623636 1169 62864179
Protein urine present 18.11 11.59 20 623654 6100 62859248
Ankle deformity 18.01 11.59 23 623651 461 62864887
Hyperkaliuria 18.01 11.59 10 623664 56 62865292
Treatment noncompliance 17.99 11.59 258 623416 37067 62828281
Blood prolactin increased 17.93 11.59 6 623668 3497 62861851
BK virus infection 17.90 11.59 5 623669 3274 62862074
Respiration abnormal 17.88 11.59 22 623652 6395 62858953
Enteritis 17.87 11.59 141 623533 8145 62857203
Hodgkin's disease 17.80 11.59 30 623644 779 62864569
Ovarian cyst 17.79 11.59 237 623437 15708 62849640
Cellulitis 17.79 11.59 642 623032 81316 62784032
Underdose 17.75 11.59 178 623496 27278 62838070
Swollen tongue 17.68 11.59 238 623436 34562 62830786
Skin abrasion 17.67 11.59 41 623633 9288 62856060
Allergy to vaccine 17.64 11.59 16 623658 213 62865135
Thermal burn 17.63 11.59 20 623654 6026 62859322
Neck surgery 17.61 11.59 49 623625 1811 62863537
Drug use disorder 17.60 11.59 96 623578 4888 62860460
Staphylococcal bacteraemia 17.58 11.59 17 623657 5513 62859835
Peritoneal tuberculosis 17.57 11.59 23 623651 473 62864875
Self-medication 17.54 11.59 3 623671 2760 62862588
Staphylococcal infection 17.49 11.59 530 623144 40726 62824622
Peripheral coldness 17.48 11.59 61 623613 12104 62853244
Breast cancer female 17.47 11.59 207 623467 13352 62851996
Suture related complication 17.46 11.59 15 623659 185 62865163
Alanine aminotransferase abnormal 17.45 11.59 89 623585 4415 62860933
Hypermobility syndrome 17.42 11.59 30 623644 793 62864555
Urticarial vasculitis 17.42 11.59 27 623647 652 62864696
Hair texture abnormal 17.41 11.59 10 623664 4233 62861115
Therapeutic response shortened 17.36 11.59 186 623488 11702 62853646
Overwork 17.33 11.59 10 623664 61 62865287
Large intestine anastomosis 17.31 11.59 8 623666 28 62865320
Decreased activity 17.26 11.59 22 623652 6298 62859050
Stoma obstruction 17.25 11.59 13 623661 131 62865217
Biliary dyskinesia 17.24 11.59 3 623671 2726 62862622
Koebner phenomenon 17.23 11.59 6 623668 7 62865341
Blood glucose abnormal 17.21 11.59 32 623642 7860 62857488
Psoriasis area severity index increased 17.20 11.59 10 623664 62 62865286
Eczema infected 17.17 11.59 9 623665 44 62865304
Steatohepatitis 17.17 11.59 26 623648 615 62864733
Blood magnesium decreased 17.13 11.59 69 623605 13129 62852219
Scleroderma 17.12 11.59 17 623657 5445 62859903
Tendon rupture 17.11 11.59 139 623535 8100 62857248
Short stature 17.10 11.59 27 623647 663 62864685
Adjustment disorder 17.06 11.59 5 623669 3173 62862175
Sleep disorder 17.05 11.59 972 622702 80594 62784754
Hyperthyroidism 17.04 11.59 80 623594 14593 62850755
Vaginal haemorrhage 17.03 11.59 180 623494 27307 62838041
Subcorneal pustular dermatosis 17.01 11.59 9 623665 45 62865303
Enzyme level increased 17.01 11.59 19 623655 329 62865019
Spinal fusion surgery 17.00 11.59 104 623570 5524 62859824
Inadequate analgesia 17.00 11.59 4 623670 2939 62862409
Respiratory alkalosis 16.99 11.59 3 623671 2698 62862650
Type I hypersensitivity 16.99 11.59 4 623670 2938 62862410
Quality of life decreased 16.95 11.59 146 623528 8657 62856691
Poor venous access 16.94 11.59 81 623593 14704 62850644
Spinal meningioma benign 16.93 11.59 12 623662 109 62865239
Paternal exposure during pregnancy 16.93 11.59 12 623662 109 62865239
Clinically isolated syndrome 16.89 11.59 8 623666 30 62865318
Vasculitis 16.88 11.59 262 623412 17947 62847401
Oral herpes 16.87 11.59 169 623505 25905 62839443
Exposed bone in jaw 16.85 11.59 4 623670 2921 62862427
Sinus disorder 16.79 11.59 157 623517 24396 62840952
Pyelonephritis 16.74 11.59 104 623570 17674 62847674
Bone density abnormal 16.73 11.59 72 623602 3326 62862022
Eye movement disorder 16.70 11.59 16 623658 5212 62860136
Tonsillolith 16.70 11.59 7 623667 18 62865330
Pulmonary haemorrhage 16.67 11.59 28 623646 7153 62858195
Desmoid tumour 16.66 11.59 11 623663 88 62865260
Axillary mass 16.61 11.59 25 623649 588 62864760
Pruritus genital 16.59 11.59 3 623671 2651 62862697
Multiple system atrophy 16.58 11.59 15 623659 199 62865149
International normalised ratio decreased 16.57 11.59 12 623662 4489 62860859
Oligohydramnios 16.53 11.59 23 623651 6343 62859005
Acquired claw toe 16.52 11.59 15 623659 200 62865148
Device breakage 16.51 11.59 58 623616 11484 62853864
Groin pain 16.50 11.59 163 623511 10040 62855308
Panic attack 16.50 11.59 140 623534 22191 62843157
Seborrhoeic dermatitis 16.49 11.59 35 623639 1086 62864262
Lipoma 16.47 11.59 57 623617 2374 62862974
Synovial fluid analysis 16.44 11.59 57 623617 2376 62862972
Skin wound 16.42 11.59 38 623636 1251 62864097
Dermatofibrosarcoma protuberans 16.39 11.59 6 623668 9 62865339
Hypoaesthesia oral 16.38 11.59 69 623605 12964 62852384
Jaw disorder 16.36 11.59 17 623657 5332 62860016
Anorectal ulcer 16.26 11.59 9 623665 50 62865298
Abortion induced 16.26 11.59 163 623511 10079 62855269
Aplasia 16.14 11.59 11 623663 4248 62861100
Stoma creation 16.13 11.59 8 623666 34 62865314
Pulmonary granuloma 16.11 11.59 40 623634 1379 62863969
Hepatitis B virus test positive 16.11 11.59 15 623659 207 62865141
Electrocardiogram T wave inversion 16.09 11.59 7 623667 3474 62861874
Cardiomegaly 16.09 11.59 104 623570 17510 62847838
Bilirubin conjugated increased 16.08 11.59 4 623670 2830 62862518
Sinus congestion 16.05 11.59 108 623566 18015 62847333
Cholecystectomy 16.03 11.59 168 623506 10509 62854839
Ventricular dysfunction 16.03 11.59 4 623670 2824 62862524
Occult blood positive 16.01 11.59 8 623666 3662 62861686
Mesangioproliferative glomerulonephritis 15.98 11.59 9 623665 52 62865296
Neoplasm of appendix 15.95 11.59 8 623666 35 62865313
Infected fistula 15.94 11.59 15 623659 210 62865138
Adhesiolysis 15.93 11.59 7 623667 21 62865327
Carbohydrate antigen 125 increased 15.93 11.59 4 623670 2812 62862536
Decreased interest 15.93 11.59 6 623668 3248 62862100
Thyroid cancer 15.90 11.59 102 623572 5509 62859839
Orthopnoea 15.88 11.59 23 623651 6238 62859110
Acute graft versus host disease in skin 15.87 11.59 7 623667 3445 62861903
Colitis ischaemic 15.86 11.59 53 623621 10655 62854693
Brain injury 15.86 11.59 28 623646 7015 62858333
Non-consummation 15.85 11.59 9 623665 53 62865295
Pulmonary sarcoidosis 15.84 11.59 33 623641 1010 62864338
Intervertebral disc calcification 15.84 11.59 5 623669 3 62865345
Guillain-Barre syndrome 15.84 11.59 78 623596 3815 62861533
Cerebral ischaemia 15.84 11.59 26 623648 6702 62858646
Hypoventilation 15.84 11.59 14 623660 4740 62860608
Skin hyperpigmentation 15.77 11.59 21 623653 5900 62859448
Chronic disease 15.76 11.59 13 623661 151 62865197
Carotid artery thrombosis 15.74 11.59 4 623670 2790 62862558
Nail operation 15.73 11.59 30 623644 860 62864488
Ileus paralytic 15.65 11.59 13 623661 4538 62860810
Pneumothorax traumatic 15.62 11.59 13 623661 153 62865195
Adverse food reaction 15.61 11.59 8 623666 37 62865311
Abortion 15.61 11.59 57 623617 2439 62862909
Tenosynovitis stenosans 15.59 11.59 70 623604 3294 62862054
Bronchial secretion retention 15.57 11.59 4 623670 2769 62862579
Pleuropericarditis 15.56 11.59 16 623658 251 62865097
Injection site laceration 15.52 11.59 11 623663 100 62865248
Post procedural fistula 15.46 11.59 16 623658 253 62865095
Lung disorder 15.44 11.59 754 622920 61507 62803841
Granulomatous lymphadenitis 15.42 11.59 13 623661 156 62865192
Hyperuricaemia 15.40 11.59 18 623656 5352 62859996
Cutaneous lupus erythematosus 15.36 11.59 60 623614 2652 62862696
Rash papular 15.35 11.59 228 623446 15474 62849874
Hereditary motor and sensory neuropathy 15.34 11.59 11 623663 102 62865246
Impetigo 15.34 11.59 38 623636 1308 62864040
Walking aid user 15.33 11.59 167 623507 10550 62854798
Disseminated large cell lymphoma 15.32 11.59 9 623665 57 62865291
Rectal tube insertion 15.32 11.59 6 623668 12 62865336
Tension 15.30 11.59 6 623668 3169 62862179
Jejunectomy 15.26 11.59 5 623669 4 62865344
Premature labour 15.22 11.59 67 623607 12437 62852911
Prurigo 15.22 11.59 30 623644 882 62864466
Butterfly rash 15.13 11.59 45 623629 1728 62863620
Blood bicarbonate decreased 15.12 11.59 5 623669 2936 62862412
Stomal hernia 15.11 11.59 16 623658 260 62865088
Rectal ulcer 15.10 11.59 36 623638 1209 62864139
Renal pain 15.07 11.59 26 623648 6573 62858775
Eating disorder 15.06 11.59 117 623557 18899 62846449
Gingival disorder 15.04 11.59 8 623666 3534 62861814
Nasal crusting 15.01 11.59 17 623657 299 62865049
Myocardial ischaemia 15.00 11.59 70 623604 12789 62852559
Hyperventilation 15.00 11.59 23 623651 6093 62859255
Dislocation of vertebra 14.98 11.59 140 623534 8495 62856853
Malignant melanoma stage I 14.97 11.59 8 623666 41 62865307
Dissociation 14.94 11.59 5 623669 2914 62862434
Lower respiratory tract inflammation 14.91 11.59 11 623663 107 62865241
Synovial rupture 14.91 11.59 15 623659 229 62865119
Oesophageal spasm 14.89 11.59 6 623668 3117 62862231
Jugular vein thrombosis 14.85 11.59 6 623668 3112 62862236
Benign lung neoplasm 14.83 11.59 9 623665 61 62865287
Prescribed overdose 14.82 11.59 440 623234 33713 62831635
Renal tubular disorder 14.81 11.59 4 623670 2678 62862670
Electrocardiogram T wave abnormal 14.80 11.59 3 623671 2444 62862904
Arteriosclerosis 14.79 11.59 50 623624 10016 62855332
T-cell lymphoma 14.78 11.59 25 623649 651 62864697
Colectomy total 14.77 11.59 13 623661 166 62865182
Eye naevus 14.75 11.59 5 623669 5 62865343
Spleen tuberculosis 14.75 11.59 5 623669 5 62865343
Gingival swelling 14.73 11.59 13 623661 4405 62860943
International normalised ratio abnormal 14.72 11.59 7 623667 3297 62862051
Tongue oedema 14.69 11.59 14 623660 4572 62860776
Culture urine positive 14.69 11.59 9 623665 3678 62861670
Therapeutic response changed 14.65 11.59 32 623642 1013 62864335
Facet joint syndrome 14.63 11.59 183 623491 11955 62853393
Lower respiratory tract infection 14.59 11.59 1499 622175 130808 62734540
Enterostomy closure 14.53 11.59 4 623670 0 62865348
Gastrointestinal dilation procedure 14.53 11.59 4 623670 0 62865348
Giant cell tumour of tendon sheath 14.53 11.59 4 623670 0 62865348
CSF white blood cell count positive 14.53 11.59 4 623670 0 62865348
Episiotomy 14.53 11.59 4 623670 0 62865348
Bacterial abdominal infection 14.53 11.59 4 623670 0 62865348
Orbital granuloma 14.53 11.59 4 623670 0 62865348
Seronegative arthritis 14.49 11.59 77 623597 3882 62861466
Hip surgery 14.46 11.59 68 623606 3263 62862085
Anorectal swelling 14.46 11.59 10 623664 87 62865261
Stoma site abscess 14.46 11.59 13 623661 171 62865177
Melkersson-Rosenthal syndrome 14.43 11.59 6 623668 15 62865333
Larynx irritation 14.43 11.59 11 623663 113 62865235
Histoplasmosis disseminated 14.42 11.59 39 623635 1417 62863931
Fungaemia 14.42 11.59 3 623671 2400 62862948
Diabetes insipidus 14.33 11.59 4 623670 2621 62862727
Metastases to spine 14.30 11.59 7 623667 3242 62862106
Peritoneal cyst 14.28 11.59 5 623669 6 62865342
Benign lymph node neoplasm 14.28 11.59 5 623669 6 62865342
Blood parathyroid hormone increased 14.22 11.59 6 623668 3032 62862316
Dental caries 14.22 11.59 56 623618 10723 62854625
Conjunctival hyperaemia 14.21 11.59 3 623671 2376 62862972
Malignant pleural effusion 14.18 11.59 4 623670 2602 62862746
Disability assessment scale score increased 14.17 11.59 7 623667 3226 62862122
Extrapulmonary tuberculosis 14.17 11.59 17 623657 319 62865029
Metastases to meninges 14.14 11.59 4 623670 2598 62862750
Cutaneous tuberculosis 14.10 11.59 12 623662 146 62865202
Enteropathic spondylitis 14.07 11.59 7 623667 30 62865318
Mycobacterial infection 14.05 11.59 44 623630 1739 62863609
Brain death 14.04 11.59 8 623666 3402 62861946
Thyroid operation 13.98 11.59 13 623661 179 62865169
Chondropathy 13.94 11.59 52 623622 2248 62863100
Synovial disorder 13.90 11.59 48 623626 1997 62863351
Cyst 13.89 11.59 205 623469 13894 62851454
Immune reconstitution inflammatory syndrome 13.87 11.59 24 623650 6060 62859288
Meningitis leptospiral 13.86 11.59 5 623669 7 62865341
Ileocaecal resection 13.84 11.59 8 623666 49 62865299
Mean cell haemoglobin concentration abnormal 13.82 11.59 11 623663 121 62865227
Urinary tract infection bacterial 13.81 11.59 18 623656 5104 62860244
Electrocardiogram ST segment elevation 13.78 11.59 11 623663 3916 62861432
Blood urine present 13.75 11.59 89 623585 14980 62850368
Post procedural discharge 13.70 11.59 21 623653 502 62864846
Liver disorder 13.70 11.59 652 623022 53035 62812313
Klebsiella infection 13.67 11.59 41 623633 8525 62856823
General physical health deterioration 13.66 11.59 2215 621459 199187 62666161
Benign neoplasm of skin 13.64 11.59 12 623662 153 62865195
Suture rupture 13.64 11.59 14 623660 219 62865129
Dysplasia 13.63 11.59 29 623645 901 62864447
Abdominal neoplasm 13.61 11.59 17 623657 333 62865015
Ovarian adenoma 13.59 11.59 16 623658 294 62865054
Benign neoplasm 13.58 11.59 30 623644 957 62864391
Blood thyroid stimulating hormone decreased 13.58 11.59 15 623659 4575 62860773
Perineal fistula 13.55 11.59 7 623667 33 62865315
Deep vein thrombosis postoperative 13.53 11.59 171 623503 11198 62854150
Bruxism 13.50 11.59 9 623665 3516 62861832
Mood altered 13.49 11.59 87 623587 14656 62850692
Central nervous system inflammation 13.48 11.59 13 623661 188 62865160
Multiple sclerosis 13.45 11.59 324 623350 24048 62841300
Blood sodium increased 13.44 11.59 5 623669 2727 62862621
Incision site inflammation 13.42 11.59 6 623668 19 62865329
Anogenital dysplasia 13.42 11.59 6 623668 19 62865329
Lip dry 13.36 11.59 220 623454 15250 62850098
Drooling 13.36 11.59 11 623663 3857 62861491
Hemiplegia 13.23 11.59 47 623627 9276 62856072
Facial pain 13.22 11.59 56 623618 10505 62854843
Granulomatous rosacea 13.20 11.59 6 623668 20 62865328
Hypercholesterolaemia 13.13 11.59 288 623386 21046 62844302
Application site pain 13.12 11.59 13 623661 4169 62861179
Anosmia 13.11 11.59 30 623644 6830 62858518
Hyperphosphataemia 13.10 11.59 3 623671 2245 62863103
Hydrocholecystis 13.08 11.59 7 623667 36 62865312
Metatarsalgia 13.06 11.59 15 623659 268 62865080
Anal inflammation 13.06 11.59 14 623660 231 62865117
Photopsia 13.05 11.59 15 623659 4494 62860854
Pathogen resistance 13.04 11.59 27 623647 6371 62858977
White blood cells urine positive 13.03 11.59 19 623655 5139 62860209
Breast mass 13.03 11.59 127 623547 7795 62857553
Sleep terror 13.02 11.59 5 623669 2675 62862673
Colonic abscess 13.00 11.59 30 623644 986 62864362
Joint instability 12.96 11.59 37 623637 1388 62863960
Hyperpyrexia 12.96 11.59 10 623664 3622 62861726
Libido decreased 12.96 11.59 5 623669 2667 62862681
Hiccups 12.95 11.59 3 623671 2228 62863120
Acute disseminated encephalomyelitis 12.89 11.59 13 623661 199 62865149
Nystagmus 12.89 11.59 26 623648 6194 62859154
Presbyacusis 12.87 11.59 6 623668 2859 62862489
Self-injurious ideation 12.85 11.59 5 623669 2654 62862694
Cholecystitis acute 12.85 11.59 40 623634 8220 62857128
Gout 12.82 11.59 77 623597 13194 62852154
Bursitis infective staphylococcal 12.78 11.59 7 623667 38 62865310
Mesenteric vascular insufficiency 12.78 11.59 7 623667 38 62865310
Incision site pruritus 12.77 11.59 6 623668 22 62865326
Ear lobe infection 12.77 11.59 5 623669 10 62865338
Disease recurrence 12.73 11.59 196 623478 27834 62837514
Precancerous skin lesion 12.72 11.59 31 623643 1056 62864292
Oral neoplasm 12.68 11.59 9 623665 82 62865266
Conjunctival haemorrhage 12.64 11.59 10 623664 3577 62861771
Sebaceous gland infection 12.58 11.59 12 623662 171 62865177
Seroconversion test positive 12.57 11.59 6 623668 23 62865325
Aortic elongation 12.57 11.59 6 623668 23 62865325
Rectal cancer metastatic 12.55 11.59 14 623660 242 62865106
Procedural complication 12.54 11.59 94 623580 5345 62860003
Adenovirus infection 12.53 11.59 10 623664 3561 62861787
Autonomic nervous system imbalance 12.51 11.59 6 623668 2812 62862536
Neonatal respiratory distress syndrome 12.51 11.59 6 623668 2812 62862536
Injection site discolouration 12.51 11.59 125 623549 7723 62857625
Mouth ulceration 12.48 11.59 418 623256 32566 62832782
Polydipsia 12.48 11.59 10 623664 3554 62861794
Cerebral atrophy 12.47 11.59 19 623655 5047 62860301
Uterine cyst 12.45 11.59 18 623656 408 62864940
Growth failure 12.44 11.59 16 623658 323 62865025
Myelodysplastic syndrome 12.39 11.59 105 623569 16649 62848699
Urine abnormality 12.39 11.59 32 623642 6987 62858361
Language disorder 12.35 11.59 3 623671 2157 62863191
Drug specific antibody absent 12.33 11.59 9 623665 86 62865262
Staphylococcal pharyngitis 12.32 11.59 4 623670 3 62865345
Ileocolostomy 12.32 11.59 4 623670 3 62865345
Social avoidant behaviour 12.32 11.59 7 623667 2981 62862367
Viral upper respiratory tract infection 12.30 11.59 123 623551 7601 62857747
Jejunal stenosis 12.22 11.59 7 623667 42 62865306
Nerve block 12.18 11.59 25 623649 757 62864591
Urine analysis abnormal 12.17 11.59 19 623655 4997 62860351
Eyelid ptosis 12.17 11.59 34 623640 7233 62858115
Swelling of eyelid 12.17 11.59 8 623666 3148 62862200
Malignant melanoma stage III 12.16 11.59 5 623669 12 62865336
Internal haemorrhage 12.12 11.59 20 623654 5145 62860203
Creatinine urine abnormal 12.09 11.59 7 623667 43 62865305
Femoral neck fracture 12.07 11.59 43 623631 8480 62856868
Glucose tolerance test abnormal 12.06 11.59 10 623664 117 62865231
Rash morbilliform 12.06 11.59 9 623665 3316 62862032
Vaginal flatulence 12.02 11.59 64 623610 3229 62862119
Volvulus of small bowel 12.01 11.59 8 623666 65 62865283
Influenza like illness 12.01 11.59 535 623139 66289 62799059
Pancreatic toxicity 12.01 11.59 6 623668 26 62865322
SARS-CoV-2 antibody test positive 12.01 11.59 6 623668 26 62865322
Ischaemic hepatitis 11.98 11.59 3 623671 2113 62863235
Breast cancer recurrent 11.97 11.59 15 623659 4326 62861022
Prescribed underdose 11.95 11.59 379 623295 29310 62836038
Wound secretion 11.94 11.59 82 623592 4532 62860816
Scar 11.91 11.59 196 623478 13586 62851762
Spinal fusion acquired 11.89 11.59 5 623669 13 62865335
Diabetic retinopathy 11.89 11.59 4 623670 2323 62863025
Haematocrit increased 11.88 11.59 4 623670 2322 62863026
Lupus vulgaris 11.85 11.59 100 623574 5894 62859454
Decubitus ulcer 11.84 11.59 58 623616 10462 62854886
Limb fracture 11.83 11.59 6 623668 27 62865321
Eosinophil morphology abnormal 11.80 11.59 4 623670 4 62865344
Perfusion brain scan abnormal 11.80 11.59 4 623670 4 62865344
Cutaneous B-cell lymphoma 11.80 11.59 4 623670 4 62865344
Gardnerella infection 11.80 11.59 4 623670 4 62865344
Pseudomyxoma peritonei 11.80 11.59 4 623670 4 62865344
Periorbital swelling 11.80 11.59 7 623667 2911 62862437
Acute psychosis 11.80 11.59 5 623669 2520 62862828
Transaminases increased 11.77 11.59 227 623447 31140 62834208
Anal cancer 11.74 11.59 20 623654 524 62864824
Localised infection 11.73 11.59 384 623290 29826 62835522
Gastrointestinal toxicity 11.72 11.59 122 623552 7619 62857729
Post procedural swelling 11.69 11.59 16 623658 344 62865004
Ear pruritus 11.69 11.59 13 623661 3952 62861396
Fracture delayed union 11.68 11.59 51 623623 2371 62862977
Vulvovaginal dryness 11.67 11.59 7 623667 2894 62862454
Petit mal epilepsy 11.67 11.59 12 623662 3782 62861566
Alcohol use 11.67 11.59 3 623671 2076 62863272
Major depression 11.66 11.59 40 623634 7978 62857370
Salt craving 11.66 11.59 10 623664 123 62865225
Cardiac pacemaker insertion 11.65 11.59 14 623660 4112 62861236
Arthroscopy 11.65 11.59 23 623651 677 62864671
Cardiolipin antibody 11.63 11.59 5 623669 14 62865334
Screaming 11.62 11.59 9 623665 3253 62862095
Communication disorder 11.60 11.59 5 623669 2495 62862853

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4145.06 11.64 8270 185267 448481 34314913
Therapy interrupted 1308.28 11.64 861 192676 12836 34750558
Joint swelling 1199.06 11.64 1565 191972 58325 34705069
Therapeutic product effect decreased 1186.38 11.64 1197 192340 33546 34729848
Arthralgia 1040.53 11.64 2649 190888 167392 34596002
Psoriasis 996.20 11.64 1150 192387 37662 34725732
Drug interaction 960.06 11.64 78 193459 225868 34537526
Acute kidney injury 824.61 11.64 330 193207 304658 34458736
Toxicity to various agents 806.10 11.64 86 193451 200276 34563118
Injection site pain 742.58 11.64 995 192542 38010 34725384
Synovitis 687.37 11.64 592 192945 13474 34749920
Intestinal stenosis 675.42 11.64 300 193237 1886 34761508
Drug intolerance 599.21 11.64 1135 192402 58435 34704959
Febrile neutropenia 595.50 11.64 42 193495 136807 34626587
Hypotension 586.69 11.64 247 193290 221402 34541992
Musculoskeletal stiffness 514.08 11.64 925 192612 45755 34717639
Therapeutic product effect incomplete 500.80 11.64 957 192580 49584 34713810
Drug abuse 495.38 11.64 11 193526 99085 34664309
Pain 477.78 11.64 2318 191219 202357 34561037
Treatment failure 469.78 11.64 890 192647 45807 34717587
Malignant neoplasm progression 451.36 11.64 7 193530 88039 34675355
Contraindicated product administered 430.21 11.64 562 192975 20919 34742475
Frequent bowel movements 429.55 11.64 437 193100 12350 34751044
C-reactive protein abnormal 426.33 11.64 367 193170 8343 34755051
Intestinal obstruction 412.59 11.64 568 192969 22254 34741140
Ileal stenosis 412.17 11.64 185 193352 1196 34762198
Neutropenia 399.78 11.64 184 193353 156594 34606800
Arthritis 393.11 11.64 658 192879 30688 34732706
Arthropathy 377.07 11.64 594 192943 26313 34737081
Disease progression 376.74 11.64 71 193466 108006 34655388
Apparent death 374.59 11.64 240 193297 3404 34759990
Thrombocytopenia 360.29 11.64 209 193328 156038 34607356
Anaemia 356.58 11.64 462 193075 232873 34530521
Psoriatic arthropathy 355.25 11.64 491 193046 19307 34744087
Drug specific antibody present 344.24 11.64 219 193318 3066 34760328
Rheumatoid arthritis 331.64 11.64 685 192852 37553 34725841
Fistula 306.26 11.64 274 193263 6566 34756828
Gastrointestinal inflammation 304.55 11.64 208 193329 3303 34760091
Completed suicide 303.20 11.64 84 193453 98084 34665310
Anal fistula 300.42 11.64 245 193292 5154 34758240
Mobility decreased 298.89 11.64 571 192966 29557 34733837
Platelet count decreased 292.10 11.64 149 193388 119568 34643826
Confusional state 286.57 11.64 227 193310 143933 34619461
Hyponatraemia 284.57 11.64 56 193481 82635 34680759
Injection site haemorrhage 271.67 11.64 302 193235 9466 34753928
Overdose 270.07 11.64 84 193453 90975 34672419
Knee arthroplasty 267.64 11.64 264 193273 7180 34756214
Large intestinal stenosis 266.46 11.64 143 193394 1424 34761970
Ankylosing spondylitis 265.89 11.64 232 193305 5372 34758022
Abdominal adhesions 265.51 11.64 141 193396 1372 34762022
Somnolence 264.12 11.64 143 193394 110973 34652421
Osteoarthritis 263.68 11.64 437 193100 20205 34743189
Tuberculosis 260.90 11.64 278 193259 8299 34755095
Bradycardia 259.66 11.64 51 193486 75367 34688027
Hyperkalaemia 258.57 11.64 38 193499 69351 34694043
Red blood cell sedimentation rate increased 250.92 11.64 281 193256 8881 34754513
Abscess 250.40 11.64 318 193219 11499 34751895
C-reactive protein increased 249.62 11.64 762 192775 53336 34710058
Impaired work ability 247.72 11.64 245 193292 6685 34756709
Inflammation 246.61 11.64 508 193029 27787 34735607
Loss of personal independence in daily activities 242.71 11.64 555 192982 32624 34730770
Lymphoma 236.17 11.64 318 193219 12189 34751205
Small intestinal obstruction 229.05 11.64 343 193194 14523 34748871
Small intestinal stenosis 227.25 11.64 92 193445 442 34762952
Surgery 224.37 11.64 331 193206 13826 34749568
Pain in extremity 223.66 11.64 1329 192208 125184 34638210
Death 221.89 11.64 1296 192241 396753 34366641
Dyspnoea 217.37 11.64 1213 192324 375569 34387825
Bone erosion 216.69 11.64 179 193358 3836 34759558
Disability 213.56 11.64 191 193346 4574 34758820
Infection 211.58 11.64 1030 192507 89885 34673509
Demyelination 211.14 11.64 161 193376 3060 34760334
Therapy cessation 210.99 11.64 355 193182 16618 34746776
Red blood cell sedimentation rate abnormal 210.56 11.64 168 193369 3421 34759973
Injection site erythema 207.64 11.64 340 193197 15559 34747835
Drug hypersensitivity 206.14 11.64 938 192599 79591 34683803
Neutrophil count decreased 202.39 11.64 23 193514 51081 34712313
Lupus-like syndrome 201.30 11.64 147 193390 2609 34760785
Abscess intestinal 201.06 11.64 121 193416 1525 34761869
Uveitis 201.05 11.64 228 193309 7307 34756087
Diverticulitis 196.97 11.64 378 193159 19626 34743768
Tuberculin test positive 194.24 11.64 105 193432 1062 34762332
Hallucination 192.31 11.64 28 193509 51470 34711924
Hypoglycaemia 192.21 11.64 35 193502 54605 34708789
Intentional overdose 190.93 11.64 13 193524 43661 34719733
Electrocardiogram QT prolonged 185.64 11.64 10 193527 40942 34722452
Rhabdomyolysis 184.70 11.64 73 193464 68090 34695304
Intestinal fistula 182.99 11.64 96 193441 909 34762485
Herpes zoster 177.19 11.64 504 193033 33895 34729499
Constipation 176.10 11.64 305 193232 136677 34626717
Intestinal fibrosis 174.39 11.64 53 193484 80 34763314
International normalised ratio increased 171.55 11.64 28 193509 47299 34716095
Sarcoidosis 171.17 11.64 136 193401 2752 34760642
Inflammatory bowel disease 169.85 11.64 136 193401 2784 34760610
Blood creatinine increased 168.77 11.64 166 193371 94810 34668584
Injection site reaction 167.88 11.64 277 193260 12756 34750638
Injection site swelling 167.72 11.64 259 193278 11268 34752126
Cardiac arrest 164.13 11.64 174 193363 95985 34667409
Injection site papule 163.40 11.64 64 193473 277 34763117
Enthesopathy 162.86 11.64 162 193375 4451 34758943
Pancytopenia 162.62 11.64 172 193365 94985 34668409
Lactic acidosis 162.40 11.64 7 193530 34765 34728629
Intestinal resection 162.18 11.64 108 193429 1641 34761753
Respiratory failure 161.36 11.64 219 193318 108353 34655041
Hypokalaemia 159.93 11.64 61 193476 58153 34705241
Hypoxia 157.70 11.64 54 193483 55041 34708353
Cardio-respiratory arrest 153.38 11.64 57 193480 55216 34708178
Disseminated tuberculosis 150.69 11.64 113 193424 2092 34761302
Colectomy 149.44 11.64 105 193432 1749 34761645
Incorrect dose administered 149.41 11.64 529 193008 39986 34723408
Pustular psoriasis 148.74 11.64 100 193437 1545 34761849
Mycobacterium tuberculosis complex test positive 147.58 11.64 92 193445 1240 34762154
Depressed level of consciousness 147.35 11.64 29 193508 42812 34720582
Drug reaction with eosinophilia and systemic symptoms 146.75 11.64 9 193528 33003 34730391
Metabolic acidosis 145.23 11.64 32 193505 43648 34719746
Sacroiliitis 142.53 11.64 94 193443 1404 34761990
Agitation 142.04 11.64 70 193467 57329 34706065
Delirium 138.84 11.64 36 193501 43955 34719439
Urticaria 138.13 11.64 697 192840 61680 34701714
Coma 137.41 11.64 41 193496 45637 34717757
Lymphadenopathy 135.98 11.64 406 193131 28057 34735337
Hypersensitivity 135.14 11.64 682 192855 60353 34703041
Gastrointestinal haemorrhage 134.98 11.64 175 193362 88302 34675092
Off label use 134.18 11.64 1583 191954 417941 34345453
Chondropathy 133.43 11.64 77 193460 893 34762501
Drug eruption 132.58 11.64 321 193216 19577 34743817
Vomiting 132.37 11.64 816 192721 246805 34516589
IgA nephropathy 131.83 11.64 84 193453 1179 34762215
Decreased appetite 130.12 11.64 478 193059 165914 34597480
Joint stiffness 129.29 11.64 223 193314 10650 34752744
Leukopenia 128.53 11.64 96 193441 62760 34700634
Gastrointestinal disorder 128.40 11.64 447 193090 33501 34729893
Renal impairment 128.31 11.64 203 193334 94310 34669084
Malignant melanoma 127.96 11.64 189 193348 7901 34755493
Tachycardia 127.95 11.64 169 193368 84603 34678791
Plasma cell myeloma 127.79 11.64 37 193500 42000 34721394
Device issue 127.54 11.64 209 193328 9568 34753826
Mental status changes 126.40 11.64 28 193509 38055 34725339
Abdominal abscess 126.40 11.64 135 193402 4040 34759354
Hidradenitis 125.63 11.64 77 193460 1005 34762389
Anal abscess 124.36 11.64 166 193371 6307 34757087
Hyperglycaemia 123.28 11.64 33 193504 39447 34723947
Atrial fibrillation 123.21 11.64 313 193224 122080 34641314
Product use in unapproved indication 120.99 11.64 297 193240 117202 34646192
Systemic lupus erythematosus 120.92 11.64 125 193412 3599 34759795
Polyarthritis 120.48 11.64 137 193400 4403 34758991
Colitis ulcerative 119.28 11.64 275 193262 16245 34747149
Sleep disorder due to general medical condition, insomnia type 118.99 11.64 80 193457 1236 34762158
Gastrointestinal stenosis 118.32 11.64 39 193498 88 34763306
Fall 118.28 11.64 650 192887 202235 34561159
Haematochezia 118.20 11.64 541 192996 45993 34717401
Joint range of motion decreased 117.35 11.64 172 193365 7140 34756254
Dehydration 116.23 11.64 352 193185 129617 34633777
Dizziness 113.68 11.64 726 192811 217795 34545599
Gastrointestinal fistula 113.14 11.64 54 193483 409 34762985
White blood cell count decreased 111.56 11.64 225 193312 95220 34668174
Pyoderma gangrenosum 110.61 11.64 79 193458 1352 34762042
Defaecation urgency 110.56 11.64 101 193436 2488 34760906
Intervertebral disc protrusion 110.36 11.64 198 193339 9758 34753636
Oxygen saturation decreased 109.00 11.64 83 193454 53735 34709659
Therapy non-responder 107.63 11.64 466 193071 38680 34724714
Encephalopathy 107.52 11.64 31 193506 35288 34728106
Gastrointestinal obstruction 104.57 11.64 64 193473 833 34762561
Gastrointestinal scarring 103.97 11.64 39 193498 146 34763248
Abdominal pain 103.58 11.64 1371 192166 162247 34601147
Drug delivery system malfunction 103.39 11.64 48 193489 339 34763055
Sedation 102.36 11.64 3 193534 21003 34742391
Acne cystic 101.93 11.64 52 193485 462 34762932
Fistula discharge 101.17 11.64 62 193475 809 34762585
Immunodeficiency 101.06 11.64 138 193399 5360 34758034
Pulmonary tuberculosis 100.80 11.64 128 193409 4626 34758768
Bone cyst 100.55 11.64 78 193459 1522 34761872
Mass 100.44 11.64 167 193370 7738 34755656
Hepatosplenic T-cell lymphoma 100.39 11.64 50 193487 420 34762974
Syncope 99.85 11.64 224 193313 91227 34672167
Septic shock 98.70 11.64 153 193384 71681 34691713
Intestinal anastomosis 98.41 11.64 42 193495 236 34763158
Arthritis bacterial 98.18 11.64 131 193406 4975 34758419
Pneumonia aspiration 97.91 11.64 55 193482 41848 34721546
Immunosuppression 97.87 11.64 146 193391 6158 34757236
Serotonin syndrome 96.57 11.64 3 193534 19930 34743464
Respiratory arrest 96.39 11.64 19 193518 28024 34735370
Fear of injection 96.10 11.64 75 193462 1477 34761917
Hypocalcaemia 95.98 11.64 11 193526 24278 34739116
Colitis 95.95 11.64 439 193098 37311 34726083
Enteritis 95.51 11.64 166 193371 7976 34755418
Tenosynovitis 95.25 11.64 122 193415 4448 34758946
Seizure 94.43 11.64 283 193254 104574 34658820
Multiple organ dysfunction syndrome 94.24 11.64 175 193362 76391 34687003
Gastrointestinal wall thickening 94.08 11.64 73 193464 1425 34761969
Blood pressure decreased 93.83 11.64 88 193449 51427 34711967
Synovial cyst 93.44 11.64 88 193449 2256 34761138
Suicide attempt 93.34 11.64 50 193487 39066 34724328
Skin plaque 92.77 11.64 121 193416 4493 34758901
Aggression 92.70 11.64 50 193487 38914 34724480
Intervertebral disc space narrowing 92.68 11.64 63 193474 992 34762402
Cardiac failure congestive 92.51 11.64 202 193335 83068 34680326
Rheumatoid factor positive 91.92 11.64 54 193483 649 34762745
Neck pain 91.73 11.64 329 193208 25020 34738374
Alanine aminotransferase abnormal 91.25 11.64 121 193416 4567 34758827
Agranulocytosis 91.16 11.64 12 193525 23809 34739585
Atlantoaxial instability 89.72 11.64 42 193495 303 34763091
Dislocation of vertebra 88.97 11.64 45 193492 392 34763002
Neoplasm progression 88.54 11.64 12 193525 23288 34740106
Orthostatic hypotension 88.17 11.64 18 193519 25901 34737493
Spinal instability 87.46 11.64 42 193495 323 34763071
Blood bilirubin increased 87.01 11.64 52 193485 38244 34725150
Hip arthroplasty 86.25 11.64 115 193422 4364 34759030
Neurotoxicity 86.22 11.64 3 193534 18007 34745387
Wheezing 86.22 11.64 62 193475 41340 34722054
Faecal calprotectin increased 85.51 11.64 87 193450 2457 34760937
Injection site pruritus 85.37 11.64 145 193392 6838 34756556
Joint ankylosis 84.65 11.64 70 193467 1502 34761892
Mineral metabolism disorder 83.70 11.64 41 193496 331 34763063
Myelosuppression 83.42 11.64 6 193531 19259 34744135
Gastrointestinal mucosa hyperaemia 83.22 11.64 38 193499 257 34763137
Mucosal inflammation 82.86 11.64 56 193481 38566 34724828
Anti-cyclic citrullinated peptide antibody positive 82.83 11.64 74 193463 1769 34761625
Impaired healing 82.20 11.64 228 193309 15106 34748288
Joint lock 81.96 11.64 63 193474 1212 34762182
Swelling 81.83 11.64 456 193081 41910 34721484
Pneumonia legionella 81.67 11.64 74 193463 1803 34761591
Tumour lysis syndrome 81.12 11.64 3 193534 17056 34746338
Injection site rash 80.54 11.64 107 193430 4046 34759348
Pulmonary thrombosis 80.43 11.64 146 193391 7261 34756133
Upper gastrointestinal haemorrhage 80.29 11.64 21 193516 25497 34737897
Cardiogenic shock 79.85 11.64 24 193513 26594 34736800
Hypoaesthesia 79.69 11.64 598 192939 60846 34702548
Neuropathy peripheral 79.13 11.64 219 193318 83044 34680350
Unresponsive to stimuli 78.91 11.64 27 193510 27542 34735852
Respiratory distress 78.84 11.64 50 193487 35615 34727779
Intentional product misuse 78.37 11.64 82 193455 45529 34717865
Joint arthroplasty 77.78 11.64 53 193484 838 34762556
Intestinal anastomosis complication 77.67 11.64 30 193507 124 34763270
Onychoclasis 77.02 11.64 72 193465 1828 34761566
Hypomagnesaemia 76.82 11.64 14 193523 21837 34741557
Restlessness 76.40 11.64 23 193514 25459 34737935
Nodule 76.07 11.64 136 193401 6683 34756711
Drug level decreased 75.67 11.64 147 193390 7699 34755695
Henoch-Schonlein purpura 75.23 11.64 67 193470 1595 34761799
Blood glucose increased 74.80 11.64 161 193376 66557 34696837
Illness 74.34 11.64 203 193334 13326 34750068
Peripheral swelling 74.29 11.64 698 192839 75843 34687551
Intestinal mucosal hypertrophy 74.10 11.64 24 193513 50 34763344
Nasopharyngitis 73.98 11.64 650 192887 69318 34694076
Small intestinal resection 73.91 11.64 42 193495 472 34762922
Mucous stools 73.27 11.64 68 193469 1710 34761684
Alopecia 73.22 11.64 298 193239 24057 34739337
Antinuclear antibody increased 72.89 11.64 37 193500 325 34763069
Intestinal perforation 72.33 11.64 157 193380 8903 34754491
Blood creatine phosphokinase increased 72.28 11.64 85 193452 44772 34718622
Urinary retention 72.15 11.64 57 193480 36231 34727163
Injection site warmth 72.02 11.64 72 193465 1990 34761404
B-cell lymphoma 72.00 11.64 104 193433 4259 34759135
Intestinal dilatation 71.83 11.64 58 193479 1202 34762192
Gastrointestinal stoma complication 71.46 11.64 59 193478 1263 34762131
Impaired quality of life 71.37 11.64 121 193416 5697 34757697
Food intolerance 71.33 11.64 61 193476 1373 34762021
Diarrhoea 71.24 11.64 1631 191906 388281 34375113
Dermatitis psoriasiform 71.10 11.64 62 193475 1434 34761960
Anal stenosis 70.53 11.64 30 193507 167 34763227
Procedural pain 69.92 11.64 108 193429 4698 34758696
Basal cell carcinoma 69.31 11.64 253 193284 19405 34743989
Enterocutaneous fistula 68.42 11.64 52 193485 983 34762411
Psychotic disorder 68.18 11.64 25 193512 24427 34738967
Cholestasis 67.97 11.64 32 193505 26916 34736478
Device defective 67.90 11.64 46 193491 720 34762674
Respiratory depression 67.71 11.64 6 193531 16239 34747155
Gastric disorder 67.69 11.64 186 193351 12255 34751139
Labelled drug-drug interaction medication error 66.61 11.64 4 193533 14935 34748459
Infusion related reaction 66.40 11.64 120 193417 52937 34710457
Dysphagia 66.28 11.64 155 193382 62226 34701168
Drug level increased 66.14 11.64 20 193517 22076 34741318
Subileus 65.96 11.64 85 193452 3118 34760276
Iridocyclitis 65.81 11.64 62 193475 1590 34761804
Therapeutic response shortened 65.73 11.64 134 193403 7270 34756124
Hepatic cirrhosis 65.46 11.64 228 193309 17086 34746308
Drug withdrawal syndrome 64.97 11.64 15 193522 19819 34743575
Intestinal ulcer 64.87 11.64 48 193489 870 34762524
Multiple sclerosis 64.70 11.64 125 193412 6520 34756874
Injection site irritation 64.68 11.64 55 193482 1228 34762166
Subdural haematoma 63.87 11.64 17 193520 20404 34742990
Bladder transitional cell carcinoma 63.57 11.64 76 193461 2579 34760815
Hallucination, visual 63.41 11.64 11 193526 17780 34745614
Stevens-Johnson syndrome 63.28 11.64 13 193524 18626 34744768
Skin lesion 63.10 11.64 265 193272 21696 34741698
Furuncle 62.80 11.64 85 193452 3273 34760121
Gastrointestinal oedema 62.80 11.64 57 193480 1392 34762002
Ileostomy 62.46 11.64 42 193495 649 34762745
Antinuclear antibody positive 62.29 11.64 56 193481 1350 34762044
Rectal stenosis 61.67 11.64 27 193510 163 34763231
Pulmonary mass 61.40 11.64 183 193354 12629 34750765
Gastrointestinal infection 61.33 11.64 113 193424 5685 34757709
Intestinal mass 61.22 11.64 38 193499 508 34762886
Terminal state 60.91 11.64 91 193446 3843 34759551
General physical health deterioration 60.68 11.64 438 193099 127831 34635563
Toxic epidermal necrolysis 60.57 11.64 22 193515 21624 34741770
Ventricular tachycardia 60.50 11.64 36 193501 26543 34736851
Musculoskeletal pain 60.37 11.64 342 193195 31621 34731773
Rheumatoid nodule 60.36 11.64 78 193459 2869 34760525
Fistula of small intestine 60.34 11.64 36 193501 446 34762948
Drug specific antibody 60.28 11.64 32 193505 311 34763083
Multiple sclerosis relapse 60.16 11.64 3 193534 13130 34750264
Loss of therapeutic response 59.56 11.64 39 193498 575 34762819
Abnormal behaviour 59.45 11.64 32 193505 24937 34738457
Rash maculo-papular 58.72 11.64 43 193494 28408 34734986
Hypervolaemia 58.70 11.64 18 193519 19691 34743703
Joint effusion 58.48 11.64 104 193433 5089 34758305
Crohn's disease 58.44 11.64 79 193458 3038 34760356
Blood alkaline phosphatase increased 58.25 11.64 52 193485 31123 34732271
Meniscus injury 58.11 11.64 67 193470 2186 34761208
Angioedema 57.91 11.64 73 193464 37301 34726093
Pouchitis 57.72 11.64 40 193497 651 34762743
Cardiac failure 57.17 11.64 285 193252 90963 34672431
Axial spondyloarthritis 56.72 11.64 31 193506 321 34763073
Intestinal sepsis 56.42 11.64 39 193498 632 34762762
Rectal discharge 56.34 11.64 28 193509 234 34763160
Stenosis 56.24 11.64 54 193483 1419 34761975
Melaena 55.98 11.64 68 193469 35312 34728082
Purulent discharge 55.88 11.64 74 193463 2789 34760605
Oedema 55.86 11.64 105 193432 45636 34717758
Cyst 55.32 11.64 94 193443 4434 34758960
Foot deformity 55.18 11.64 94 193443 4443 34758951
No adverse event 55.14 11.64 29 193508 22898 34740496
Drug tolerance decreased 55 11.64 61 193476 1906 34761488
Ulcer 54.07 11.64 138 193399 8697 34754697
Tooth loss 53.77 11.64 85 193452 3773 34759621
Nephrolithiasis 53.67 11.64 319 193218 30014 34733380
Altered state of consciousness 53.54 11.64 30 193507 22863 34740531
Sinus bradycardia 53.46 11.64 5 193532 12958 34750436
Osteosclerosis 53.34 11.64 50 193487 1274 34762120
Bone marrow failure 53.22 11.64 50 193487 29203 34734191
Asthenia 53.20 11.64 997 192540 244254 34519140
Adhesion 53.07 11.64 38 193499 653 34762741
Injection site urticaria 52.41 11.64 61 193476 2011 34761383
Squamous cell carcinoma 52.27 11.64 161 193376 11314 34752080
Post procedural inflammation 52.23 11.64 15 193522 16 34763378
Post procedural complication 52.08 11.64 160 193377 11228 34752166
Vein rupture 51.95 11.64 42 193495 872 34762522
Delusion 51.77 11.64 5 193532 12630 34750764
Neoplasm malignant 51.69 11.64 233 193304 19672 34743722
Blood urea increased 51.69 11.64 55 193482 30309 34733085
Inguinal hernia 51.67 11.64 124 193413 7517 34755877
Optic neuritis 51.56 11.64 80 193457 3494 34759900
Diarrhoea haemorrhagic 51.49 11.64 115 193422 6649 34756745
Palmoplantar pustulosis 51.36 11.64 21 193516 104 34763290
Enterocolonic fistula 51.16 11.64 20 193517 86 34763308
Hyperbilirubinaemia 50.86 11.64 15 193522 16828 34746566
Folliculitis 50.85 11.64 91 193446 4475 34758919
Accidental overdose 50.66 11.64 24 193513 20116 34743278
Disseminated intravascular coagulation 50.43 11.64 29 193508 21787 34741607
Cholangitis sclerosing 50.34 11.64 50 193487 1371 34762023
Anastomotic stenosis 50.12 11.64 27 193510 271 34763123
Poisoning 49.67 11.64 5 193532 12221 34751173
Injection site bruising 49.62 11.64 132 193405 8531 34754863
Blood pressure systolic increased 49.60 11.64 33 193504 22919 34740475
Faecal calprotectin abnormal 49.50 11.64 25 193512 217 34763177
Intestinal polyp 49.43 11.64 43 193494 991 34762403
Acute respiratory failure 49.40 11.64 59 193478 30869 34732525
Cutaneous leishmaniasis 49.28 11.64 24 193513 191 34763203
Acne 49.23 11.64 154 193383 10912 34752482
Osteolysis 49.00 11.64 73 193464 3075 34760319
Rotator cuff syndrome 48.69 11.64 101 193436 5548 34757846
Latent tuberculosis 48.36 11.64 48 193489 1315 34762079
Obstructive airways disorder 48.27 11.64 13 193524 15481 34747913
Blood pressure increased 48.13 11.64 288 193249 87814 34675580
Extrapyramidal disorder 48.07 11.64 7 193530 12873 34750521
Shock 48.04 11.64 38 193499 24141 34739253
Anorectal disorder 48.02 11.64 44 193493 1088 34762306
Iritis 47.92 11.64 49 193488 1392 34762002
Cytology abnormal 47.74 11.64 29 193508 372 34763022
Rectal abscess 47.62 11.64 48 193489 1340 34762054
Oedema peripheral 47.51 11.64 429 193108 119383 34644011
Inappropriate antidiuretic hormone secretion 47.44 11.64 7 193530 12746 34750648
Postoperative wound infection 47.25 11.64 91 193446 4735 34758659
Medical device implantation 47.10 11.64 34 193503 592 34762802
Inflammatory marker increased 47.03 11.64 93 193444 4935 34758459
Rash pustular 46.97 11.64 97 193440 5311 34758083
Ileectomy 46.86 11.64 16 193521 42 34763352
Clostridium difficile infection 46.69 11.64 218 193319 18680 34744714
Road traffic accident 46.62 11.64 206 193331 17244 34746150
Adverse drug reaction 46.52 11.64 300 193237 29042 34734352
Testis cancer 46.45 11.64 48 193489 1381 34762013
Perirectal abscess 46.35 11.64 52 193485 1646 34761748
Scar 46.31 11.64 102 193435 5842 34757552
Pulmonary sarcoidosis 46.29 11.64 33 193504 563 34762831
Lymph node tuberculosis 46.24 11.64 30 193507 435 34762959
Disorientation 46.22 11.64 70 193467 33118 34730276
Erythrodermic psoriasis 45.97 11.64 39 193498 868 34762526
Intentional dose omission 45.89 11.64 75 193462 3425 34759969
Granuloma 45.82 11.64 72 193465 3179 34760215
Tooth fracture 45.68 11.64 77 193460 3608 34759786
Lymphocyte count decreased 45.64 11.64 35 193502 22587 34740807
Dactylitis 45.41 11.64 39 193498 883 34762511
Pulmonary hypertension 45.33 11.64 30 193507 20894 34742500
Cutaneous T-cell lymphoma 45.27 11.64 49 193488 1489 34761905
Dystonia 45.22 11.64 4 193533 10841 34752553
Bursitis 45.20 11.64 96 193441 5362 34758032
Skin mass 45.12 11.64 80 193457 3905 34759489
Arthroscopy 45.05 11.64 18 193519 83 34763311
Haemorrhage intracranial 44.97 11.64 16 193521 15930 34747464
Heart rate increased 44.68 11.64 121 193416 46222 34717172
Device malfunction 44.51 11.64 143 193394 10278 34753116
Haematuria 44.40 11.64 136 193401 49930 34713464
Proctitis 44.30 11.64 61 193476 2388 34761006
Normal newborn 44.12 11.64 21 193516 158 34763236
Thrombotic microangiopathy 44.11 11.64 4 193533 10626 34752768
Osteonecrosis of jaw 43.96 11.64 22 193515 17867 34745527
Neutropenic sepsis 43.94 11.64 11 193526 13756 34749638
Ileostomy closure 43.70 11.64 16 193521 55 34763339
Haemodialysis 43.57 11.64 4 193533 10522 34752872
Accident at work 43.32 11.64 36 193501 778 34762616
Circulatory collapse 43.15 11.64 32 193505 21006 34742388
Full blood count abnormal 42.89 11.64 25 193512 18643 34744751
Stomatitis 42.88 11.64 391 193146 42123 34721271
Purulence 42.60 11.64 37 193500 851 34762543
Colon dysplasia 42.56 11.64 19 193518 121 34763273
Hepatitis B virus test positive 42.45 11.64 25 193512 302 34763092
Cognitive disorder 42.45 11.64 58 193479 28635 34734759
Generalised tonic-clonic seizure 42.42 11.64 33 193504 21141 34742253
Ileal ulcer 42.42 11.64 32 193505 598 34762796
Status epilepticus 42.41 11.64 9 193528 12605 34750789
Steroid dependence 42.34 11.64 47 193490 1470 34761924
Histoplasmosis 42.31 11.64 47 193490 1471 34761923
Paradoxical psoriasis 42.17 11.64 12 193525 12 34763382
Allergic oedema 42.06 11.64 14 193523 33 34763361
Gastrointestinal anastomotic stenosis 42.02 11.64 10 193527 0 34763394
Adverse food reaction 42.02 11.64 10 193527 0 34763394
Herpes simplex oesophagitis 42.00 11.64 21 193516 178 34763216
Eosinophilia 41.90 11.64 50 193487 26172 34737222
Full blood count decreased 41.87 11.64 24 193513 18064 34745330
Abdominal lymphadenopathy 41.81 11.64 36 193501 818 34762576
Urinary tract infection 41.75 11.64 283 193254 83798 34679596
Withdrawal syndrome 41.64 11.64 9 193528 12446 34750948
Tachypnoea 41.57 11.64 25 193512 18327 34745067
Hepatocellular injury 41.55 11.64 37 193500 22174 34741220
Pseudopolyp 41.52 11.64 22 193515 213 34763181
Seminoma 41.34 11.64 22 193515 215 34763179
Night sweats 41.29 11.64 198 193339 17154 34746240
Alopecia areata 41.25 11.64 22 193515 216 34763178
Dyskinesia 41.14 11.64 38 193499 22375 34741019
Coccidioidomycosis 40.98 11.64 34 193503 733 34762661
Vertebral osteophyte 40.87 11.64 15 193522 52 34763342
Product substitution issue 40.85 11.64 136 193401 9959 34753435
Flushing 40.85 11.64 73 193464 32347 34731047
Pulmonary oedema 40.82 11.64 131 193406 47398 34715996
Hip surgery 40.71 11.64 40 193497 1082 34762312
Dry mouth 40.70 11.64 65 193472 30100 34733294
Photosensitivity reaction 40.47 11.64 140 193397 10454 34752940
Aphthous ulcer 40.38 11.64 87 193450 4908 34758486
Colonic fistula 40.27 11.64 27 193510 415 34762979
Diabetic ketoacidosis 40.23 11.64 25 193512 18007 34745387
Postoperative adhesion 40.18 11.64 16 193521 73 34763321
Loss of consciousness 40.18 11.64 280 193257 82387 34681007
Hepatic cytolysis 40.11 11.64 15 193522 14481 34748913
Lethargy 39.92 11.64 107 193430 41015 34722379
Post procedural fistula 39.84 11.64 16 193521 75 34763319
Hepatic failure 39.80 11.64 82 193455 34449 34728945
Inflammatory pain 39.39 11.64 21 193516 206 34763188
Dysarthria 38.91 11.64 84 193453 34698 34728696
Sinusitis 38.87 11.64 375 193162 41027 34722367
Appendicectomy 38.86 11.64 39 193498 1083 34762311
T-cell lymphoma 38.79 11.64 37 193500 964 34762430
Cartilage atrophy 38.76 11.64 12 193525 20 34763374
Gastrointestinal pain 38.69 11.64 70 193467 3472 34759922
Hernia 38.68 11.64 129 193408 9454 34753940
Muscle rigidity 38.60 11.64 6 193531 10512 34752882
Cerebral haemorrhage 38.57 11.64 85 193452 34852 34728542
Injection site extravasation 38.51 11.64 63 193474 2879 34760515
Gamma-glutamyltransferase increased 38.49 11.64 64 193473 29167 34734227
Colonoscopy abnormal 38.46 11.64 15 193522 64 34763330
Physical disability 38.46 11.64 43 193494 1356 34762038
Nephropathy toxic 38.39 11.64 11 193526 12577 34750817
Urinary incontinence 38.34 11.64 29 193508 18845 34744549
Subcutaneous abscess 38.28 11.64 73 193464 3770 34759624
Fatigue 38.19 11.64 1671 191866 368982 34394412
Venous injury 38.14 11.64 23 193514 291 34763103
Clinically isolated syndrome 37.82 11.64 9 193528 0 34763394
Procedural intestinal perforation 37.71 11.64 11 193526 13 34763381
Hepatic steatosis 37.70 11.64 201 193336 18161 34745233
Renal injury 37.61 11.64 8 193529 11187 34752207
Knee operation 37.58 11.64 52 193485 2045 34761349
Surgical failure 37.57 11.64 15 193522 69 34763325
Colon cancer 37.46 11.64 119 193418 8502 34754892
Irritability 37.44 11.64 49 193488 24641 34738753
Ileocaecal resection 37.41 11.64 14 193523 52 34763342
Gastrointestinal dysplasia 37.27 11.64 11 193526 14 34763380
Post procedural diarrhoea 37.23 11.64 15 193522 71 34763323
Cholecystectomy 36.95 11.64 61 193476 2809 34760585
Joint injury 36.60 11.64 123 193414 9050 34754344
Sensitivity to weather change 36.42 11.64 45 193492 1581 34761813
Spondylitis 36.37 11.64 40 193497 1238 34762156
Post procedural infection 36.34 11.64 82 193455 4774 34758620
Headache 36.14 11.64 1405 192132 199230 34564164
Pneumonitis 36.11 11.64 84 193453 33794 34729600
Spinal pain 36.05 11.64 92 193445 5797 34757597
Renal neoplasm 35.88 11.64 40 193497 1257 34762137
Nail psoriasis 35.79 11.64 15 193522 80 34763314
Atrial flutter 35.57 11.64 21 193516 15553 34747841
Drug level abnormal 35.50 11.64 19 193518 188 34763206
Pleural effusion 35.44 11.64 285 193252 81261 34682133
Prescribed underdose 35.40 11.64 4 193533 8929 34754465
Hallucination, auditory 35.28 11.64 11 193526 11906 34751488
Fluid retention 35.28 11.64 59 193478 26828 34736566
Rectal haemorrhage 35.09 11.64 359 193178 39890 34723504
Skin exfoliation 34.99 11.64 266 193271 27166 34736228
Hodgkin's disease 34.97 11.64 33 193504 848 34762546
Spondyloarthropathy 34.92 11.64 29 193508 626 34762768
Haemoglobin decreased 34.86 11.64 465 193072 120307 34643087
Wrist deformity 34.73 11.64 23 193514 346 34763048
Aspartate aminotransferase increased 34.72 11.64 226 193311 67557 34695837
Hepatic encephalopathy 34.69 11.64 19 193518 14666 34748728
Amyotrophic lateral sclerosis 34.55 11.64 35 193502 983 34762411
Double stranded DNA antibody positive 34.50 11.64 19 193518 200 34763194
Carpal tunnel syndrome 34.47 11.64 79 193458 4647 34758747
Coronary artery occlusion 34.44 11.64 136 193401 10826 34752568
Pulmonary arterial hypertension 34.42 11.64 4 193533 8735 34754659
Localised infection 34.41 11.64 190 193347 17397 34745997
Rheumatoid factor negative 34.40 11.64 33 193504 866 34762528
Hypothyroidism 34.32 11.64 39 193498 20863 34742531
Stoma site abscess 34.24 11.64 12 193525 35 34763359
Tendonitis 34.23 11.64 120 193417 9020 34754374
Arthritis enteropathic 34.11 11.64 16 193521 116 34763278
Dysplasia 34.02 11.64 32 193505 819 34762575
Tropical infectious disease 33.99 11.64 12 193525 36 34763358
Pain of skin 33.89 11.64 92 193445 6017 34757377
Sinus tachycardia 33.59 11.64 28 193509 17332 34746062
Proctalgia 33.59 11.64 88 193449 5635 34757759
Jaundice 33.23 11.64 80 193457 31802 34731592
Skin injury 33.14 11.64 52 193485 2293 34761101
Acute respiratory distress syndrome 33.14 11.64 58 193479 25911 34737483
Wound complication 33.06 11.64 52 193485 2298 34761096
Prescribed overdose 33.04 11.64 9 193528 10638 34752756
Lymphadenitis 32.97 11.64 48 193489 1980 34761414
Legionella infection 32.65 11.64 25 193512 478 34762916
Tremor 32.59 11.64 296 193241 82291 34681103
Chronic kidney disease 32.39 11.64 118 193419 41092 34722302
Joint warmth 32.38 11.64 23 193514 390 34763004
Ventricular fibrillation 32.37 11.64 48 193489 22906 34740488
Paraesthesia 32.29 11.64 517 193020 63655 34699739
Colostomy 32.22 11.64 25 193512 488 34762906
Psychomotor hyperactivity 32.07 11.64 7 193530 9615 34753779
Paternal drugs affecting foetus 31.98 11.64 12 193525 45 34763349
Hepatic enzyme abnormal 31.93 11.64 56 193481 2710 34760684
Erythema nodosum 31.90 11.64 39 193498 1355 34762039
Incisional hernia 31.73 11.64 38 193499 1292 34762102
Glioblastoma 31.63 11.64 34 193503 1025 34762369
Blood pressure diastolic decreased 31.59 11.64 6 193531 9088 34754306
Intervertebral disc annular tear 31.48 11.64 10 193527 19 34763375
Blood potassium increased 31.43 11.64 27 193510 16468 34746926
Arthritis reactive 31.42 11.64 21 193516 321 34763073
Coagulopathy 31.34 11.64 38 193499 19751 34743643
Haemoptysis 31.10 11.64 95 193442 34911 34728483
Anhedonia 31.08 11.64 3 193534 7582 34755812
Malaise 31.06 11.64 1291 192246 184534 34578860
Ileal perforation 31.00 11.64 29 193508 737 34762657
Haematemesis 30.93 11.64 67 193470 27644 34735750
Hypernatraemia 30.81 11.64 5 193532 8485 34754909
Guttate psoriasis 30.80 11.64 19 193518 251 34763143
Acute hepatic failure 30.73 11.64 20 193517 14054 34749340
Spinal osteoarthritis 30.64 11.64 103 193434 7580 34755814
Tonsillitis 30.64 11.64 51 193486 2365 34761029
Oligoarthritis 30.63 11.64 15 193522 121 34763273
Anastomotic ulcer 30.55 11.64 21 193516 337 34763057
Anal fissure 30.51 11.64 71 193466 4219 34759175
Seronegative arthritis 30.40 11.64 33 193504 1006 34762388
Staphylococcal infection 30.39 11.64 296 193241 32464 34730930
Oliguria 30.26 11.64 5 193532 8375 34755019
Haematoma 30.19 11.64 60 193477 25545 34737849
Injury associated with device 29.99 11.64 34 193503 1089 34762305
Acquired hydrocele 29.92 11.64 12 193525 56 34763338
Blood lactate dehydrogenase increased 29.65 11.64 51 193486 22939 34740455
Dysgeusia 29.63 11.64 64 193473 26433 34736961
Enterovesical fistula 29.59 11.64 29 193508 782 34762612
Intestinal cyst 29.41 11.64 7 193530 0 34763394
Histoplasmosis disseminated 29.37 11.64 37 193500 1326 34762068
Chronic recurrent multifocal osteomyelitis 29.35 11.64 10 193527 26 34763368
Cytopenia 29.28 11.64 17 193520 12706 34750688
X-ray abnormal 29.25 11.64 23 193514 458 34762936
Anal ulcer 29.23 11.64 30 193507 856 34762538
Gastrointestinal tract adenoma 29.23 11.64 18 193519 237 34763157
Tongue disorder 29.22 11.64 80 193457 5259 34758135
Oral surgery 29.18 11.64 25 193512 564 34762830
Pleurisy 29.16 11.64 74 193463 4647 34758747
Lung cancer metastatic 29.08 11.64 54 193483 2733 34760661
Cell marker increased 29.03 11.64 22 193515 414 34762980
Malignant melanoma stage I 28.96 11.64 13 193524 84 34763310
Substance abuse 28.87 11.64 4 193533 7637 34755757
Obstruction 28.77 11.64 53 193484 2666 34760728
Skin ulcer 28.65 11.64 216 193321 22000 34741394
Rheumatic disorder 28.64 11.64 25 193512 579 34762815
Small intestine adenocarcinoma 28.59 11.64 15 193522 142 34763252
Heart rate decreased 28.31 11.64 86 193451 31659 34731735
Large intestinal ulcer 28.30 11.64 44 193493 1925 34761469
Precancerous skin lesion 28.28 11.64 25 193512 589 34762805
Ascites 28.27 11.64 147 193390 46424 34716970
Pancreatitis acute 28.24 11.64 72 193465 28069 34735325
Blood sodium decreased 28.15 11.64 29 193508 16222 34747172
Terminal ileitis 28.13 11.64 17 193520 216 34763178
Postoperative abscess 27.96 11.64 19 193518 299 34763095
Arrhythmia 27.83 11.64 103 193434 35705 34727689
Cytomegalovirus infection 27.70 11.64 65 193472 26070 34737324
Jejunal stenosis 27.66 11.64 11 193526 50 34763344
Ileocolectomy 27.64 11.64 8 193529 9 34763385
Pathogen resistance 27.63 11.64 9 193528 9473 34753921
Acidosis 27.59 11.64 13 193524 10932 34752462
Tuberculosis gastrointestinal 27.40 11.64 17 193520 227 34763167
Limb traumatic amputation 27.40 11.64 9 193528 20 34763374
Adenocarcinoma of colon 27.34 11.64 59 193478 3332 34760062
Abdominal hernia 27.18 11.64 52 193485 2692 34760702
Renal tubular necrosis 27.14 11.64 28 193509 15652 34747742
Acute myocardial infarction 27.06 11.64 180 193357 53539 34709855
Eye inflammation 27.03 11.64 46 193491 2172 34761222
Polychondritis 27.02 11.64 17 193520 233 34763161
Wound secretion 27.01 11.64 51 193486 2614 34760780
DNA antibody positive 26.98 11.64 11 193526 54 34763340
Bladder transitional cell carcinoma stage II 26.82 11.64 11 193526 55 34763339
Glomerulonephritis 26.77 11.64 43 193494 1935 34761459
Post procedural swelling 26.75 11.64 15 193522 164 34763230
Product quality issue 26.67 11.64 33 193504 17002 34746392
Bronchospasm 26.66 11.64 13 193524 10718 34752676
Superficial spreading melanoma stage unspecified 26.59 11.64 15 193522 166 34763228
Electrocardiogram abnormal 26.55 11.64 9 193528 9238 34754156
Multifocal motor neuropathy 26.54 11.64 10 193527 38 34763356
Testicular seminoma (pure) 26.50 11.64 11 193526 57 34763337
Infected fistula 26.44 11.64 15 193522 168 34763226
Prerenal failure 26.44 11.64 44 193493 2040 34761354
COVID-19 pneumonia 26.43 11.64 33 193504 16934 34746460
Posterior reversible encephalopathy syndrome 26.39 11.64 11 193526 9943 34753451
Shock haemorrhagic 26.37 11.64 15 193522 11339 34752055
Stoma complication 26.36 11.64 19 193518 330 34763064
Arthropod bite 26.32 11.64 52 193485 2757 34760637
Anal hypoaesthesia 26.27 11.64 7 193530 4 34763390
Respiratory rate increased 26.12 11.64 11 193526 9883 34753511
Adenocarcinoma 26.02 11.64 42 193495 1898 34761496
Rheumatoid lung 25.97 11.64 29 193508 913 34762481
Granulocytopenia 25.88 11.64 3 193534 6564 34756830
Arthrodesis 25.77 11.64 21 193516 441 34762953
Aspiration 25.72 11.64 18 193519 12176 34751218
Colostomy closure 25.58 11.64 10 193527 43 34763351
Prothrombin time prolonged 25.58 11.64 10 193527 9396 34753998
Poisoning deliberate 25.56 11.64 6 193531 7838 34755556
Fine motor skill dysfunction 25.52 11.64 40 193497 1762 34761632
Nausea 25.51 11.64 1582 191955 338326 34425068
Lymphadenopathy mediastinal 25.36 11.64 48 193489 2465 34760929
Hypothermia 25.25 11.64 14 193523 10734 34752660
Nerve compression 25.24 11.64 56 193481 3223 34760171
Heavy exposure to ultraviolet light 25.11 11.64 7 193530 6 34763388
Systemic lupus erythematosus rash 25.05 11.64 11 193526 67 34763327
Blood phosphorus increased 24.97 11.64 6 193531 7715 34755679
Dyspnoea exertional 24.95 11.64 139 193398 43140 34720254
Anaphylactic shock 24.83 11.64 31 193506 15910 34747484
Pulmonary haemorrhage 24.83 11.64 13 193524 10291 34753103
Influenza like illness 24.81 11.64 248 193289 27386 34736008
Disturbance in attention 24.81 11.64 68 193469 25877 34737517
Electrolyte imbalance 24.64 11.64 26 193511 14386 34749008
Blood iron decreased 24.62 11.64 75 193462 5238 34758156
Back pain 24.58 11.64 864 192673 120925 34642469
Stomal hernia 24.55 11.64 16 193521 234 34763160
Tendon rupture 24.50 11.64 90 193447 6922 34756472
Psoas abscess 24.44 11.64 23 193514 589 34762805
Unevaluable event 24.39 11.64 282 193255 32308 34731086
Pseudopolyposis 24.38 11.64 10 193527 50 34763344
Mycobacterium marinum infection 24.36 11.64 17 193520 280 34763114
Pharyngitis streptococcal 24.33 11.64 49 193488 2635 34760759
Face oedema 24.29 11.64 17 193520 11499 34751895
Atrial septal defect acquired 24.29 11.64 8 193529 18 34763376
Skin disorder 24.26 11.64 143 193394 13412 34749982
Ejection fraction decreased 24.24 11.64 43 193494 19111 34744283
Hepatitis cholestatic 24.13 11.64 7 193530 7940 34755454
Anxiety 24.11 11.64 396 193141 99032 34664362
Progressive multifocal leukoencephalopathy 24.00 11.64 12 193525 9752 34753642
Second primary malignancy 23.85 11.64 7 193530 7879 34755515
Postoperative wound complication 23.81 11.64 23 193514 609 34762785
Anuria 23.72 11.64 14 193523 10371 34753023
Laryngeal cancer 23.68 11.64 25 193512 738 34762656
Aplasia pure red cell 23.67 11.64 3 193534 6129 34757265
Glycosylated haemoglobin increased 23.66 11.64 17 193520 11343 34752051
Oral herpes 23.58 11.64 76 193461 5471 34757923
Renal colic 23.56 11.64 39 193498 1800 34761594
Decubitus ulcer 23.42 11.64 10 193527 8911 34754483
Intentional self-injury 23.37 11.64 25 193512 13746 34749648
Granuloma skin 23.35 11.64 32 193505 1247 34762147
Abdominal mass 23.31 11.64 34 193503 1405 34761989
Short-bowel syndrome 23.26 11.64 16 193521 257 34763137
Acute graft versus host disease 23.22 11.64 4 193533 6499 34756895
Non-Hodgkin's lymphoma 23.22 11.64 35 193502 1490 34761904
Muscle spasms 23.08 11.64 561 192976 74440 34688954
Dialysis 23.05 11.64 17 193520 11191 34752203
Large intestinal obstruction 23.04 11.64 35 193502 1500 34761894
Central nervous system inflammation 23.03 11.64 15 193522 219 34763175
Asthma 22.98 11.64 140 193397 42516 34720878
Stent placement 22.89 11.64 71 193466 5007 34758387
Musculoskeletal discomfort 22.89 11.64 97 193440 7971 34755423
Retroperitoneal abscess 22.82 11.64 14 193523 183 34763211
Hepatic enzyme increased 22.82 11.64 323 193214 38757 34724637
Lower gastrointestinal haemorrhage 22.66 11.64 12 193525 9440 34753954
Balance disorder 22.66 11.64 132 193405 40522 34722872
Extrapulmonary tuberculosis 22.65 11.64 11 193526 87 34763307
Dyschezia 22.61 11.64 34 193503 1444 34761950
Umbilical hernia 22.59 11.64 67 193470 4610 34758784
C-reactive protein decreased 22.42 11.64 40 193497 1962 34761432
Soft tissue swelling 22.40 11.64 21 193516 535 34762859
Chronic inflammatory demyelinating polyradiculoneuropathy 22.39 11.64 24 193513 721 34762673
Spinal operation 22.35 11.64 50 193487 2894 34760500
Leukocytosis 22.32 11.64 64 193473 24001 34739393
Joint dislocation 22.29 11.64 57 193480 3596 34759798
Colonic abscess 22.25 11.64 20 193517 482 34762912
Paracoccidioides infection 22.23 11.64 10 193527 65 34763329
Lymphopenia 22.22 11.64 35 193502 16300 34747094
Rash papular 22.12 11.64 114 193423 10164 34753230
Thyroiditis subacute 22.10 11.64 9 193528 44 34763350
Inappropriate schedule of product administration 21.97 11.64 475 193062 61821 34701573
Tenderness 21.76 11.64 86 193451 6848 34756546
Bacteraemia 21.73 11.64 48 193489 19669 34743725
BK virus infection 21.69 11.64 3 193534 5735 34757659
Limb operation 21.64 11.64 24 193513 750 34762644
End stage renal disease 21.62 11.64 11 193526 8850 34754544
Mania 21.48 11.64 13 193524 9498 34753896
Extradural abscess 21.43 11.64 25 193512 826 34762568
Angina pectoris 21.36 11.64 95 193442 31268 34732126
Cutaneous lymphoma 21.35 11.64 11 193526 100 34763294
Renal cell carcinoma 21.31 11.64 69 193468 4979 34758415
Hospice care 21.28 11.64 6 193531 6934 34756460
Rectal ulcer 21.23 11.64 27 193510 977 34762417
Euphoric mood 21.21 11.64 3 193534 5638 34757756
Bronchial neoplasm 21.09 11.64 6 193531 6 34763388
CSF oligoclonal band present 21.09 11.64 6 193531 6 34763388
Hypophosphataemia 21.07 11.64 18 193519 11008 34752386
Peritoneal tuberculosis 21.06 11.64 17 193520 352 34763042
Sarcoid-like reaction 21.01 11.64 5 193532 0 34763394
Salivary gland adenoma 21.01 11.64 5 193532 0 34763394
Aplastic anaemia 20.95 11.64 14 193523 9702 34753692
Phototherapy 20.92 11.64 8 193529 32 34763362
Bursitis infective staphylococcal 20.88 11.64 7 193530 17 34763377
Immobile 20.80 11.64 44 193493 2450 34760944
Abnormal dreams 20.70 11.64 8 193529 7570 34755824
Thyroid cancer 20.69 11.64 35 193502 1645 34761749
Alanine aminotransferase increased 20.55 11.64 319 193218 80496 34682898
Coronary artery disease 20.44 11.64 170 193367 48135 34715259
Polyuria 20.39 11.64 11 193526 8563 34754831
Paranoia 20.38 11.64 22 193515 12046 34751348
Blood glucose decreased 20.35 11.64 26 193511 13211 34750183
Periumbilical abscess 20.33 11.64 9 193528 56 34763338
Acrochordon 20.32 11.64 17 193520 371 34763023
Ligament rupture 20.18 11.64 27 193510 1028 34762366
Anorectal stenosis 20.17 11.64 6 193531 8 34763386
Myelodysplastic syndrome 20.17 11.64 48 193489 19160 34744234
Adrenal insufficiency 20.17 11.64 29 193508 14018 34749376
Hypovolaemic shock 20.16 11.64 7 193530 7078 34756316
Haemodynamic instability 20.16 11.64 14 193523 9509 34753885
Weight decreased 20.06 11.64 1180 192357 175121 34588273
Wound 20.01 11.64 146 193391 14718 34748676
Parkinsonism 20.01 11.64 10 193527 8128 34755266
Cirrhosis alcoholic 19.99 11.64 24 193513 818 34762576
Alopecia universalis 19.87 11.64 11 193526 117 34763277
Hypogammaglobulinaemia 19.81 11.64 9 193528 7731 34755663
Post procedural discharge 19.81 11.64 15 193522 282 34763112
Intestinal haemorrhage 19.75 11.64 53 193484 3443 34759951
Skin fissures 19.65 11.64 69 193468 5190 34758204
Myopathy 19.58 11.64 21 193516 11533 34751861
Joint instability 19.55 11.64 18 193519 448 34762946
Ill-defined disorder 19.52 11.64 138 193399 13771 34749623
Activated partial thromboplastin time prolonged 19.47 11.64 12 193525 8683 34754711
Pulmonary fibrosis 19.47 11.64 171 193366 18225 34745169
Pelvic abscess 19.46 11.64 25 193512 914 34762480
Sepsis 19.39 11.64 740 192797 165821 34597573
Body temperature increased 19.38 11.64 42 193495 17326 34746068
Serositis 19.33 11.64 13 193524 201 34763193
Hypersensitivity vasculitis 19.28 11.64 51 193486 3284 34760110
Dermal cyst 19.26 11.64 36 193501 1831 34761563
Toxic encephalopathy 19.25 11.64 3 193534 5246 34758148
Intentional product use issue 19.23 11.64 225 193312 59591 34703803
Melanocytic naevus 19.14 11.64 41 193496 2303 34761091
Injection site haematoma 19.14 11.64 35 193502 1750 34761644
Pulseless electrical activity 19.07 11.64 8 193529 7203 34756191
Therapeutic response decreased 19.05 11.64 247 193290 29066 34734328
Gastrointestinal erosion 19.04 11.64 17 193520 406 34762988
Asphyxia 19.03 11.64 7 193530 6828 34756566
Acne conglobata 19.02 11.64 6 193531 11 34763383
Ocular sarcoidosis 19.02 11.64 6 193531 11 34763383
Shoulder operation 18.81 11.64 27 193510 1099 34762295
Heparin-induced thrombocytopenia 18.79 11.64 4 193533 5591 34757803
Migraine 18.77 11.64 163 193374 17315 34746079
Postoperative thrombosis 18.70 11.64 7 193530 26 34763368
Nodular melanoma 18.68 11.64 10 193527 99 34763295
Malignant polyp 18.68 11.64 5 193532 3 34763391
Product administration error 18.67 11.64 39 193498 16305 34747089
Prostate cancer 18.67 11.64 316 193221 39333 34724061
Intervertebral discitis 18.63 11.64 39 193498 2156 34761238
Hypoalbuminaemia 18.62 11.64 24 193513 12150 34751244
Hiccups 18.61 11.64 17 193520 10065 34753329
Cartilage injury 18.60 11.64 19 193518 539 34762855
Cytomegalovirus infection reactivation 18.60 11.64 3 193534 5115 34758279
Ataxia 18.54 11.64 30 193507 13823 34749571
Meningioma benign 18.50 11.64 7 193530 27 34763367
Abscess bacterial 18.50 11.64 12 193525 174 34763220
Nightmare 18.49 11.64 32 193505 14359 34749035
Drain placement 18.44 11.64 9 193528 72 34763322
Brain oedema 18.43 11.64 30 193507 13791 34749603
Injection site paraesthesia 18.39 11.64 11 193526 137 34763257
Haemolysis 18.37 11.64 11 193526 8083 34755311
Drug use disorder 18.34 11.64 58 193479 4133 34759261
Cervical spinal stenosis 18.33 11.64 28 193509 1206 34762188
Eczema 18.30 11.64 169 193368 18267 34745127
Myelitis 18.27 11.64 23 193514 824 34762570
Myositis 18.25 11.64 24 193513 12046 34751348
Product complaint 18.24 11.64 5 193532 5885 34757509
Subarachnoid haemorrhage 18.23 11.64 26 193511 12609 34750785
Haemorrhage 18.19 11.64 189 193348 51181 34712213
Abdominal operation 18.18 11.64 10 193527 105 34763289
Small intestine ulcer 18.17 11.64 17 193520 432 34762962
Skin laceration 18.08 11.64 125 193412 12384 34751010
Precancerous cells present 18.04 11.64 8 193529 50 34763344
Proctectomy 18.02 11.64 10 193527 107 34763287
Abscess rupture 17.93 11.64 7 193530 30 34763364
Potentiating drug interaction 17.90 11.64 3 193534 4974 34758420
Keratoacanthoma 17.90 11.64 20 193517 630 34762764
Axillary mass 17.87 11.64 12 193525 185 34763209
Spinal disorder 17.84 11.64 58 193479 4194 34759200
Gynaecomastia 17.82 11.64 18 193519 10162 34753232
Small intestinal perforation 17.76 11.64 38 193499 2133 34761261
Red blood cell sedimentation rate 17.71 11.64 27 193510 1161 34762233
Exostosis 17.68 11.64 62 193475 4661 34758733
Cutaneous symptom 17.67 11.64 14 193523 282 34763112
Cutaneous sarcoidosis 17.66 11.64 11 193526 148 34763246
Body temperature decreased 17.66 11.64 28 193509 13006 34750388
Electromyogram abnormal 17.66 11.64 8 193529 53 34763341
Therapeutic response changed 17.63 11.64 17 193520 449 34762945
Panniculitis 17.59 11.64 36 193501 1958 34761436
Bladder neck operation 17.57 11.64 5 193532 5 34763389
Anorectal swelling 17.57 11.64 5 193532 5 34763389
Self-consciousness 17.53 11.64 8 193529 54 34763340
Abdominal wall abscess 17.50 11.64 18 193519 515 34762879
Pneumonia 17.46 11.64 1750 191787 360877 34402517
Epstein-Barr virus antibody positive 17.46 11.64 14 193523 287 34763107
Skin papilloma 17.42 11.64 37 193500 2066 34761328
Abnormal faeces 17.38 11.64 49 193488 3276 34760118
Acute myeloid leukaemia 17.38 11.64 48 193489 18222 34745172
Speech disorder 17.37 11.64 78 193459 25608 34737786
Ankle operation 17.37 11.64 13 193524 240 34763154
Bone marrow oedema 17.36 11.64 20 193517 652 34762742
Polyarteritis nodosa 17.34 11.64 14 193523 290 34763104
Scab 17.34 11.64 61 193476 4593 34758801
Blindness unilateral 17.33 11.64 60 193477 4482 34758912
Right ventricular failure 17.20 11.64 14 193523 8770 34754624
Bladder neoplasm 17.20 11.64 29 193508 1359 34762035
Visceral leishmaniasis 17.15 11.64 19 193518 593 34762801
Atypical fibroxanthoma 17.12 11.64 12 193525 199 34763195
Dyshidrotic eczema 17.10 11.64 11 193526 157 34763237
Intestinal mucosal atrophy 17.10 11.64 5 193532 6 34763388
Medication error 17.07 11.64 78 193459 25487 34737907
Animal bite 16.95 11.64 19 193518 601 34762793
Mesenteritis 16.91 11.64 7 193530 36 34763358
Grip strength decreased 16.86 11.64 47 193490 3122 34760272
Papilloma viral infection 16.85 11.64 17 193520 475 34762919
Hepatic fibrosis 16.83 11.64 60 193477 4547 34758847
Anal skin tags 16.82 11.64 9 193528 89 34763305
Large intestine erosion 16.81 11.64 4 193533 0 34763394
Fibrosing colonopathy 16.81 11.64 4 193533 0 34763394
Post viral fatigue syndrome 16.81 11.64 4 193533 0 34763394
Stricturoplasty 16.81 11.64 4 193533 0 34763394
Anal polyp 16.81 11.64 4 193533 0 34763394
Ocular fistula 16.81 11.64 4 193533 0 34763394
Inflammatory marker test 16.81 11.64 4 193533 0 34763394
Injection site nodule 16.80 11.64 32 193505 1651 34761743
Hot flush 16.79 11.64 48 193489 18018 34745376
Hypergammaglobulinaemia benign monoclonal 16.77 11.64 15 193522 359 34763035
Hypercalcaemia 16.77 11.64 38 193499 15430 34747964
Urticarial vasculitis 16.75 11.64 7 193530 37 34763357
Enzyme abnormality 16.74 11.64 13 193524 254 34763140
Haemolytic anaemia 16.72 11.64 20 193517 10459 34752935
Obsessive-compulsive disorder 16.72 11.64 5 193532 5559 34757835
Suicidal ideation 16.70 11.64 143 193394 40245 34723149
Respiratory syncytial virus infection 16.59 11.64 3 193534 4706 34758688
Rheumatoid factor increased 16.55 11.64 18 193519 550 34762844
Hypovolaemia 16.54 11.64 16 193521 9218 34754176
Immune system disorder 16.51 11.64 64 193473 5051 34758343
Brain neoplasm 16.49 11.64 47 193490 3162 34760232
Neoplasm prostate 16.49 11.64 13 193524 260 34763134
Failure to thrive 16.48 11.64 14 193523 8587 34754807
Cardiac operation 16.45 11.64 46 193491 3061 34760333
Infection susceptibility increased 16.45 11.64 20 193517 691 34762703
Gastrointestinal anastomotic leak 16.43 11.64 16 193521 428 34762966
Musculoskeletal disorder 16.39 11.64 73 193464 6131 34757263
Colon neoplasm 16.37 11.64 16 193521 430 34762964
Hepatitis acute 16.33 11.64 11 193526 7590 34755804
Chromaturia 16.29 11.64 35 193502 14485 34748909
Lipoma 16.23 11.64 32 193505 1694 34761700
Kidney infection 16.21 11.64 66 193471 5328 34758066
Product dose omission issue 16.19 11.64 522 193015 119189 34644205
Product substitution 16.16 11.64 7 193530 41 34763353
Mental impairment 16.15 11.64 20 193517 10302 34753092
Pleuropericarditis 16.15 11.64 12 193525 219 34763175
Ageusia 16.10 11.64 20 193517 10288 34753106
Tonsillar disorder 16.05 11.64 12 193525 221 34763173
Dizziness postural 16.04 11.64 7 193530 6157 34757237
Pancreatic duct stenosis 16.03 11.64 11 193526 176 34763218
Eye infection staphylococcal 16.03 11.64 7 193530 42 34763352
Glomerulonephritis rapidly progressive 16.03 11.64 19 193518 639 34762755
Tardive dyskinesia 16.00 11.64 6 193531 5784 34757610
Skin wound 15.97 11.64 15 193522 383 34763011
General symptom 15.96 11.64 22 193515 862 34762532
Osteopenia 15.92 11.64 61 193476 4788 34758606
Staphylococcal abscess 15.91 11.64 19 193518 644 34762750
Cyanosis 15.84 11.64 29 193508 12735 34750659
White matter lesion 15.83 11.64 21 193516 793 34762601
Angina unstable 15.82 11.64 25 193512 11628 34751766
Spinal laminectomy 15.68 11.64 13 193524 280 34763114
Acute generalised exanthematous pustulosis 15.67 11.64 9 193528 6767 34756627
Wrong product administered 15.65 11.64 5 193532 5329 34758065
Underdose 15.64 11.64 33 193504 13747 34749647
Groin abscess 15.57 11.64 19 193518 659 34762735
Joint noise 15.57 11.64 19 193518 659 34762735
Alcoholic liver disease 15.55 11.64 18 193519 590 34762804
Autoimmune haemolytic anaemia 15.55 11.64 3 193534 4493 34758901
Fibromyalgia 15.54 11.64 45 193492 3055 34760339
Gastric bypass 15.52 11.64 13 193524 284 34763110
SAPHO syndrome 15.52 11.64 13 193524 284 34763110
Bile duct stone 15.51 11.64 40 193497 2537 34760857
Gastroenterostomy 15.50 11.64 7 193530 46 34763348
Type 2 diabetes mellitus 15.43 11.64 146 193391 15886 34747508
Brain natriuretic peptide increased 15.42 11.64 6 193531 5653 34757741
Hepatic infection fungal 15.41 11.64 11 193526 188 34763206
Visual evoked potentials abnormal 15.41 11.64 8 193529 74 34763320
Wrong technique in device usage process 15.41 11.64 29 193508 1483 34761911
Demyelinating polyneuropathy 15.32 11.64 26 193511 1225 34762169
Angiotensin converting enzyme increased 15.32 11.64 8 193529 75 34763319
Testicular seminoma (pure) stage I 15.31 11.64 6 193531 26 34763368
Lung cyst 15.31 11.64 6 193531 26 34763368
Exposure to communicable disease 15.30 11.64 10 193527 147 34763247
Perineal fistula 15.26 11.64 5 193532 11 34763383
Transfusion 15.23 11.64 15 193522 8570 34754824
Antibiotic therapy 15.23 11.64 8 193529 76 34763318
Electrocardiogram ST segment elevation 15.21 11.64 5 193532 5233 34758161
Tricuspid valve incompetence 15.18 11.64 19 193518 9741 34753653
Urine output decreased 15.18 11.64 20 193517 10029 34753365
Sleep disorder due to a general medical condition 15.13 11.64 5 193532 5216 34758178
Computerised tomogram abdomen abnormal 15.13 11.64 6 193531 27 34763367
Mesenteric abscess 15.13 11.64 6 193531 27 34763367
Rectal cancer 15.12 11.64 36 193501 2171 34761223
Spinal cord abscess 15.01 11.64 12 193525 245 34763149
Low birth weight baby 14.99 11.64 13 193524 7892 34755502
Procedural nausea 14.96 11.64 8 193529 79 34763315
Oral pain 14.92 11.64 23 193514 10804 34752590
Gastric haemorrhage 14.91 11.64 21 193516 10240 34753154
Blood loss anaemia 14.91 11.64 14 193523 8180 34755214
Carditis 14.88 11.64 11 193526 199 34763195
Vitiligo 14.85 11.64 22 193515 922 34762472
Dermatomyositis 14.84 11.64 26 193511 1257 34762137
Antiphospholipid syndrome 14.81 11.64 16 193521 485 34762909
Nasal sinus cancer 14.79 11.64 6 193531 29 34763365
Colon operation 14.79 11.64 11 193526 201 34763193
Mesangioproliferative glomerulonephritis 14.78 11.64 7 193530 52 34763342
Nocturia 14.74 11.64 21 193516 10189 34753205
Treatment noncompliance 14.73 11.64 93 193444 28007 34735387
Intra-abdominal fluid collection 14.72 11.64 26 193511 1265 34762129
Hyperlipidaemia 14.71 11.64 37 193500 14492 34748902
Heart rate irregular 14.69 11.64 42 193495 15765 34747629
Spinal stenosis 14.68 11.64 63 193474 5206 34758188
Inflammation of wound 14.68 11.64 5 193532 13 34763381
Non-Hodgkin's lymphoma stage IV 14.59 11.64 4 193533 3 34763391
Tuberculosis of intrathoracic lymph nodes 14.59 11.64 4 193533 3 34763391
Streptococcal abscess 14.59 11.64 4 193533 3 34763391
Testicular germ cell cancer 14.59 11.64 4 193533 3 34763391
SLE arthritis 14.59 11.64 4 193533 3 34763391
Non-cardiac chest pain 14.58 11.64 3 193534 4294 34759100
Limb discomfort 14.58 11.64 108 193429 10939 34752455
Gout 14.55 11.64 56 193481 19197 34744197
Influenza 14.53 11.64 369 193168 49297 34714097
Rehabilitation therapy 14.52 11.64 21 193516 861 34762533
Antibody test abnormal 14.52 11.64 11 193526 207 34763187
Stoma site ulcer 14.47 11.64 6 193531 31 34763363
Anaphylactic reaction 14.43 11.64 112 193425 32189 34731205
Pelvic pain 14.42 11.64 38 193499 2442 34760952
Granuloma annulare 14.31 11.64 10 193527 165 34763229
Product use issue 14.27 11.64 255 193282 62961 34700433
Foot operation 14.27 11.64 19 193518 720 34762674
Large intestine anastomosis 14.24 11.64 7 193530 57 34763337
Cervical vertebral fracture 14.23 11.64 33 193504 1956 34761438
Benign abdominal neoplasm 14.22 11.64 8 193529 88 34763306
Neutrophil count increased 14.20 11.64 48 193489 17098 34746296
Investigation abnormal 14.15 11.64 16 193521 511 34762883
Priapism 14.10 11.64 5 193532 4989 34758405
Ventricular hypertrophy 14.10 11.64 4 193533 4603 34758791
Blood cholesterol abnormal 14.08 11.64 31 193506 1775 34761619
Hyperthermia 14.07 11.64 23 193514 10554 34752840
Mycobacterium tuberculosis complex test 14.06 11.64 4 193533 4 34763390
Supraventricular tachycardia 14.03 11.64 25 193512 11092 34752302
Dental caries 14.01 11.64 56 193481 4483 34758911
Hyperplasia 13.99 11.64 17 193520 587 34762807
Rebound psoriasis 13.96 11.64 9 193528 129 34763265
Genital hypoaesthesia 13.95 11.64 11 193526 220 34763174
Bladder cancer recurrent 13.94 11.64 14 193523 389 34763005
Intervertebral disc displacement 13.90 11.64 9 193528 130 34763264
Rectal neoplasm 13.88 11.64 6 193531 35 34763359
Haematocrit decreased 13.80 11.64 113 193424 32103 34731291
Irritable bowel syndrome 13.79 11.64 48 193489 3595 34759799
Benign neoplasm 13.78 11.64 11 193526 224 34763170
Arthritis infective 13.78 11.64 46 193491 3373 34760021
Thirst 13.77 11.64 14 193523 7881 34755513
Colectomy total 13.76 11.64 10 193527 176 34763218
Abdominal pain lower 13.75 11.64 103 193434 10468 34752926
Clostridium difficile colitis 13.75 11.64 43 193494 15687 34747707
Fear 13.73 11.64 23 193514 10453 34752941
Ureterolithiasis 13.73 11.64 35 193502 2204 34761190
Psoriasis area severity index increased 13.60 11.64 6 193531 37 34763357
Small cell lung cancer metastatic 13.59 11.64 13 193524 340 34763054
Intestinal operation 13.58 11.64 11 193526 229 34763165
Episcleritis 13.57 11.64 10 193527 180 34763214
Gastrointestinal adenocarcinoma 13.55 11.64 7 193530 64 34763330
Spondylolisthesis 13.53 11.64 19 193518 758 34762636
Gait inability 13.52 11.64 175 193362 20583 34742811
Pyrexia 13.52 11.64 1626 191911 331387 34432007
Osteochondrosis 13.50 11.64 23 193514 1087 34762307
Patient-device incompatibility 13.48 11.64 5 193532 18 34763376
Benign neoplasm of prostate 13.48 11.64 5 193532 18 34763376
Pulmonary alveolar haemorrhage 13.47 11.64 13 193524 7499 34755895
Product storage error 13.46 11.64 84 193453 8038 34755356
Pustule 13.43 11.64 16 193521 541 34762853
Blood parathyroid hormone decreased 13.39 11.64 27 193510 1453 34761941
Ventricular hypokinesia 13.38 11.64 7 193530 5545 34757849
Blood calcium decreased 13.35 11.64 22 193515 10062 34753332
Electrocardiogram Q waves 13.34 11.64 6 193531 39 34763355
Vitamin D deficiency 13.33 11.64 72 193465 6536 34756858
Cerebral infarction 13.32 11.64 93 193444 27362 34736032
Adverse reaction 13.31 11.64 42 193495 2989 34760405
Hyperphosphataemia 13.31 11.64 4 193533 4433 34758961
Ventricular arrhythmia 13.28 11.64 7 193530 5521 34757873
Cutaneous tuberculosis 13.28 11.64 8 193529 101 34763293
Pharyngeal neoplasm 13.27 11.64 5 193532 19 34763375
Drug level changed 13.25 11.64 13 193524 351 34763043
Bradyphrenia 13.21 11.64 5 193532 4793 34758601
Liver function test increased 13.21 11.64 131 193406 14434 34748960
Bone abscess 13.20 11.64 10 193527 188 34763206
Brain herniation 13.19 11.64 3 193534 4005 34759389
False positive tuberculosis test 13.18 11.64 4 193533 6 34763388
Large cell lung cancer 13.18 11.64 4 193533 6 34763388
Stitch abscess 13.18 11.64 4 193533 6 34763388
Troponin increased 13.16 11.64 27 193510 11362 34752032
Duodenal stenosis 13.15 11.64 11 193526 240 34763154
Memory impairment 13.14 11.64 165 193372 43153 34720241
Fracture displacement 13.08 11.64 8 193529 104 34763290
Splenectomy 13.05 11.64 14 193523 421 34762973
Pulse absent 13.01 11.64 8 193529 5795 34757599
Finger deformity 12.98 11.64 27 193510 1486 34761908
Product contamination physical 12.97 11.64 6 193531 42 34763352
Viral infection 12.96 11.64 152 193385 17471 34745923
Peritonitis bacterial 12.91 11.64 9 193528 6101 34757293
Infectious mononucleosis 12.87 11.64 17 193520 639 34762755
Tuberculosis of central nervous system 12.81 11.64 10 193527 197 34763197
Post procedural oedema 12.80 11.64 4 193533 7 34763387
Renal scan abnormal 12.80 11.64 4 193533 7 34763387
Carcinoid tumour pulmonary 12.80 11.64 4 193533 7 34763387
Nutritional condition abnormal 12.79 11.64 14 193523 431 34762963
Cyst rupture 12.77 11.64 7 193530 73 34763321
Terminal insomnia 12.73 11.64 16 193521 572 34762822
Malignant melanoma in situ 12.73 11.64 29 193508 1699 34761695
Injection site vesicles 12.72 11.64 18 193519 723 34762671
Drug dose omission by device 12.70 11.64 34 193503 2205 34761189
Ventricular dysfunction 12.70 11.64 3 193534 3902 34759492
Skin cancer 12.65 11.64 99 193438 10198 34753196
Metabolic encephalopathy 12.64 11.64 4 193533 4288 34759106
Skin bacterial infection 12.63 11.64 8 193529 111 34763283
Wisdom teeth removal 12.63 11.64 8 193529 111 34763283
Dermatopathic lymphadenopathy 12.61 11.64 3 193534 0 34763394
Pelvic pouch procedure 12.61 11.64 3 193534 0 34763394
Bone atrophy 12.61 11.64 3 193534 0 34763394
Gallbladder cancer metastatic 12.61 11.64 3 193534 0 34763394
Endocrine neoplasm 12.61 11.64 3 193534 0 34763394
Diverticular fistula 12.61 11.64 3 193534 0 34763394
Tonsil cancer metastatic 12.61 11.64 3 193534 0 34763394
Lichen nitidus 12.61 11.64 3 193534 0 34763394
Lip and/or oral cavity cancer stage 0 12.61 11.64 3 193534 0 34763394
Arthritis viral 12.61 11.64 3 193534 0 34763394
Cerebrospinal fistula 12.61 11.64 3 193534 0 34763394
Bone giant cell tumour benign 12.61 11.64 3 193534 0 34763394
Seminal vesicular disorder 12.61 11.64 3 193534 0 34763394
Small intestinal anastomosis 12.61 11.64 3 193534 0 34763394
Duodenal operation 12.61 11.64 3 193534 0 34763394
DNA antibody 12.61 11.64 3 193534 0 34763394
Infected vasculitis 12.61 11.64 3 193534 0 34763394
Pleomorphic adenoma 12.61 11.64 3 193534 0 34763394
Male genital tract fistula 12.61 11.64 3 193534 0 34763394
Mucosal atrophy 12.60 11.64 7 193530 75 34763319
B-cell lymphoma stage IV 12.60 11.64 7 193530 75 34763319
Injection site hypersensitivity 12.60 11.64 12 193525 312 34763082
Stress 12.56 11.64 237 193300 30110 34733284
Abscess sterile 12.52 11.64 5 193532 23 34763371
Tuberculosis of eye 12.51 11.64 6 193531 46 34763348
Symptom recurrence 12.50 11.64 18 193519 735 34762659
Granulomatous dermatitis 12.49 11.64 11 193526 258 34763136
Metastatic bronchial carcinoma 12.48 11.64 12 193525 316 34763078
Hernia repair 12.47 11.64 24 193513 1248 34762146
Myasthenia gravis 12.46 11.64 12 193525 6928 34756466
Beta haemolytic streptococcal infection 12.45 11.64 15 193522 513 34762881
Synovectomy 12.45 11.64 7 193530 77 34763317
Mydriasis 12.44 11.64 13 193524 7224 34756170
Erythema 12.44 11.64 606 192931 88174 34675220
Bursitis infective 12.41 11.64 16 193521 587 34762807
Oropharyngeal pain 12.32 11.64 270 193267 35215 34728179
Erythema multiforme 12.28 11.64 18 193519 8631 34754763
Hyperthyroidism 12.25 11.64 25 193512 10541 34752853
Atrioventricular block 12.23 11.64 16 193521 8047 34755347
Renal amyloidosis 12.22 11.64 7 193530 80 34763314
Mucocutaneous leishmaniasis 12.22 11.64 7 193530 80 34763314
Pneumonia bacterial 12.20 11.64 30 193507 11842 34751552
Cutaneous lupus erythematosus 12.19 11.64 18 193519 752 34762642
Rectal lesion 12.19 11.64 6 193531 49 34763345
Pseudomonas infection 12.18 11.64 32 193505 12350 34751044
Overgrowth bacterial 12.16 11.64 8 193529 119 34763275
Lung perforation 12.14 11.64 4 193533 9 34763385
Benign salivary gland neoplasm 12.14 11.64 4 193533 9 34763385
Gastrointestinal stoma output decreased 12.14 11.64 7 193530 81 34763313
Metastatic gastric cancer 12.12 11.64 9 193528 164 34763230
Discomfort 12.06 11.64 159 193378 18779 34744615
Hypoxic-ischaemic encephalopathy 12.03 11.64 5 193532 4527 34758867
Gastric neoplasm 12.00 11.64 7 193530 83 34763311
Chest discomfort 11.98 11.64 221 193316 54309 34709085
Ecchymosis 11.94 11.64 12 193525 6791 34756603
Acanthosis 11.93 11.64 8 193529 123 34763271
Cardiolipin antibody positive 11.88 11.64 5 193532 27 34763367
Bone giant cell tumour 11.88 11.64 5 193532 27 34763367
Foreign body in gastrointestinal tract 11.85 11.64 4 193533 10 34763384
Tooth infection 11.84 11.64 71 193466 6700 34756694
Ventricular extrasystoles 11.83 11.64 31 193506 11977 34751417
Benign lung neoplasm 11.78 11.64 7 193530 86 34763308
Haemorrhoidal haemorrhage 11.77 11.64 3 193534 3708 34759686
Oesophagitis 11.77 11.64 36 193501 13225 34750169
Rash vesicular 11.76 11.64 38 193499 2739 34760655
Dandruff 11.73 11.64 10 193527 224 34763170
Allergic respiratory symptom 11.73 11.64 5 193532 28 34763366
Enterococcal infection 11.68 11.64 21 193516 9285 34754109
Rash 11.65 11.64 1406 192131 221346 34542048

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 7643.13 10.90 20332 531047 1060581 78132428
Therapy interrupted 5819.15 10.90 3266 548113 28075 79164934
Drug intolerance 3288.65 10.90 6254 545125 257865 78935144
Synovitis 2962.14 10.90 4381 546998 146353 79046656
Joint swelling 2922.26 10.90 6272 545107 282374 78910635
Therapeutic product effect decreased 2682.42 10.90 4378 547001 159485 79033524
Treatment failure 2438.10 10.90 4289 547090 166197 79026812
Contraindicated product administered 2398.79 10.90 4075 547304 153463 79039546
Toxicity to various agents 1978.00 10.90 283 551096 421257 78771752
Drug interaction 1956.82 10.90 275 551104 414908 78778101
Arthropathy 1842.91 10.90 3895 547484 173216 79019793
Acute kidney injury 1841.60 10.90 648 550731 518756 78674253
Arthralgia 1732.91 10.90 8174 543205 563629 78629380
Psoriasis 1691.12 10.90 2557 548822 87030 79105979
Hypotension 1560.73 10.90 549 550830 439768 78753241
Completed suicide 1362.08 10.90 85 551294 245682 78947327
Febrile neutropenia 1342.45 10.90 60 551319 230939 78962070
Therapeutic product effect incomplete 1326.86 10.90 2987 548392 138658 79054351
Systemic lupus erythematosus 1231.12 10.90 2640 548739 118509 79074500
C-reactive protein abnormal 1221.67 10.90 1588 549791 46779 79146230
Musculoskeletal stiffness 1153.05 10.90 3228 548151 171780 79021229
Pain 1068.25 10.90 8409 542970 695393 78497616
Hand deformity 1065.42 10.90 2273 549106 101646 79091363
Injection site pain 1047.10 10.90 2583 548796 127255 79065754
Drug abuse 1046.26 10.90 15 551364 162676 79030333
Neutropenia 1033.60 10.90 350 551029 287360 78905649
Swelling 973.02 10.90 3502 547877 213209 78979800
Infection 932.41 10.90 3721 547658 237991 78955018
Red blood cell sedimentation rate increased 932.08 10.90 1357 550022 44585 79148424
Rheumatoid factor positive 925.35 10.90 1560 549819 58279 79134730
Pemphigus 923.17 10.90 2092 549287 97490 79095519
Alopecia 907.98 10.90 3581 547798 227774 78965235
Anaemia 896.42 10.90 1055 550324 443960 78749049
Anti-cyclic citrullinated peptide antibody positive 888.60 10.90 1850 549529 81293 79111716
Malignant neoplasm progression 876.73 10.90 12 551367 135978 79057031
Thrombocytopenia 864.17 10.90 376 551003 264883 78928126
Death 807.58 10.90 1694 549685 564820 78628189
Hyponatraemia 806.44 10.90 131 551248 177717 79015292
Rheumatoid arthritis 805.12 10.90 3211 548168 205259 78987750
Psoriatic arthropathy 798.05 10.90 1705 549674 76294 79116715
Glossodynia 778.76 10.90 2004 549375 101333 79091676
Drug hypersensitivity 772.82 10.90 4091 547288 294825 78898184
Somnolence 768.53 10.90 345 551034 238636 78954373
Arthritis 747.28 10.90 2110 549269 112770 79080239
Red blood cell sedimentation rate abnormal 744.64 10.90 819 550560 20144 79172865
Intestinal stenosis 714.64 10.90 398 550981 3356 79189653
Hypersensitivity 693.42 10.90 3612 547767 258627 78934382
Abdominal discomfort 690.47 10.90 3493 547886 247234 78945775
Dyspnoea 683.89 10.90 3328 548051 853697 78339312
Loss of personal independence in daily activities 668.99 10.90 1886 549493 100694 79092315
Bradycardia 666.03 10.90 78 551301 135479 79057530
Overdose 663.09 10.90 223 551156 183983 79009026
C-reactive protein increased 656.02 10.90 2174 549205 126853 79066156
Platelet count decreased 653.00 10.90 264 551115 194400 78998609
Intentional overdose 641.09 10.90 20 551359 105940 79087069
Disease progression 634.95 10.90 240 551139 184122 79008887
Hepatic enzyme increased 620.48 10.90 2705 548674 179905 79013104
Wound 616.20 10.90 1986 549393 114193 79078816
Bone erosion 614.48 10.90 686 550693 17161 79175848
Inflammation 613.57 10.90 1726 549653 92027 79100982
Pericarditis 612.08 10.90 1846 549533 102390 79090619
Cardiac arrest 587.70 10.90 227 551152 171869 79021140
Mobility decreased 582.69 10.90 2015 549364 120160 79072849
Electrocardiogram QT prolonged 550.65 10.90 16 551363 90370 79102639
Hyperkalaemia 544.51 10.90 73 551306 114325 79078684
Lupus-like syndrome 526.48 10.90 561 550818 13296 79179713
Constipation 525.57 10.90 713 550666 282337 78910672
Ileal stenosis 522.43 10.90 278 551101 2120 79190889
Osteoarthritis 517.03 10.90 1551 549828 85758 79107251
Oxygen saturation decreased 471.75 10.90 152 551227 128895 79064114
Pancytopenia 470.70 10.90 281 551098 165464 79027545
Rash 470.26 10.90 6080 545299 572278 78620731
Knee arthroplasty 468.53 10.90 968 550411 42280 79150729
Rhabdomyolysis 465.06 10.90 77 551302 103054 79089955
Peripheral swelling 462.20 10.90 3320 548059 266297 78926712
Hypoglycaemia 457.80 10.90 76 551303 101518 79091491
Cardio-respiratory arrest 455.23 10.90 97 551282 108413 79084596
White blood cell count decreased 454.73 10.90 380 550999 187908 79005101
Neutrophil count decreased 454.28 10.90 57 551322 93902 79099107
Helicobacter infection 452.79 10.90 1280 550099 68424 79124585
Discomfort 450.54 10.90 1892 549487 123725 79069284
Depressed level of consciousness 445.22 10.90 68 551311 96584 79096425
Lactic acidosis 437.85 10.90 10 551369 70349 79122660
Tachycardia 437.69 10.90 352 551027 177416 79015593
International normalised ratio increased 436.02 10.90 41 551338 84680 79108329
Respiratory failure 433.33 10.90 368 551011 180543 79012466
Injection site haemorrhage 432.59 10.90 728 550651 27142 79165867
Duodenal ulcer perforation 432.17 10.90 1218 550161 64993 79128016
Hypoxia 431.66 10.90 93 551286 103150 79089859
Anal fistula 431.62 10.90 369 551010 6575 79186434
Coma 424.22 10.90 89 551290 100560 79092449
Agitation 414.51 10.90 91 551288 99624 79093385
Metabolic acidosis 409.05 10.90 46 551333 82483 79110526
Atrial fibrillation 404.31 10.90 463 550916 197423 78995586
Dehydration 402.02 10.90 686 550693 247501 78945508
Large intestinal stenosis 389.25 10.90 244 551135 2612 79190397
Hypokalaemia 383.24 10.90 263 551116 143777 79049232
Therapy cessation 380.47 10.90 818 550561 36744 79156265
Hallucination 380.04 10.90 67 551312 85678 79107331
Drug reaction with eosinophilia and systemic symptoms 378.55 10.90 15 551364 64229 79128780
Impaired healing 375.41 10.90 1396 549983 86259 79106750
Drug specific antibody present 374.27 10.90 334 551045 6318 79186691
Gastrointestinal haemorrhage 366.75 10.90 290 551089 147429 79045580
Illness 361.58 10.90 913 550466 45598 79147411
Ankylosing spondylitis 359.58 10.90 433 550946 11772 79181237
Joint stiffness 354.17 10.90 836 550543 39994 79153015
Renal impairment 343.55 10.90 350 551029 157433 79035576
Seizure 342.96 10.90 483 550896 188351 79004658
Pustular psoriasis 339.44 10.90 275 551104 4531 79188478
Adverse drug reaction 334.83 10.90 1116 550263 65276 79127733
Disability 331.71 10.90 495 550884 16625 79176384
Intestinal obstruction 328.72 10.90 839 550540 42181 79150828
Sedation 328.39 10.90 6 551373 51889 79141120
Surgery 326.64 10.90 709 550670 32057 79160952
Injection site erythema 323.75 10.90 1232 550147 76965 79116044
Gastrointestinal disorder 320.87 10.90 1681 549698 120524 79072485
Vomiting 310.65 10.90 3025 548354 662803 78530206
Sinusitis 310.61 10.90 2365 549014 193136 78999873
Fall 308.76 10.90 2039 549340 485590 78707419
Folliculitis 308.34 10.90 963 550416 54417 79138592
Hip arthroplasty 307.83 10.90 730 550649 35026 79157983
Multiple organ dysfunction syndrome 304.90 10.90 231 551148 120015 79072994
Encephalopathy 302.33 10.90 51 551328 67346 79125663
Blood pressure decreased 300.56 10.90 156 551223 99310 79093699
Dizziness 297.44 10.90 2275 549104 524166 78668843
Gastrointestinal inflammation 292.93 10.90 309 551070 7235 79185774
Neoplasm progression 291.75 10.90 16 551363 51666 79141343
Tremor 291.33 10.90 453 550926 169630 79023379
Hyperglycaemia 290.67 10.90 65 551314 70270 79122739
Respiratory arrest 290.49 10.90 30 551349 57520 79135489
Serotonin syndrome 290.00 10.90 4 551375 45023 79147986
Nasopharyngitis 289.12 10.90 2853 548526 251028 78941981
Tuberculosis 288.14 10.90 435 550944 14763 79178246
Multiple sclerosis relapse 284.28 10.90 8 551371 46525 79146484
Injection site reaction 283.48 10.90 929 550450 53856 79139153
Irritable bowel syndrome 283.14 10.90 1011 550368 61230 79131779
Suicide attempt 281.99 10.90 110 551269 82822 79110187
Enthesopathy 281.91 10.90 374 551005 11234 79181775
Confusional state 281.56 10.90 1186 550193 316811 78876198
Blood creatinine increased 280.14 10.90 398 550981 154659 79038350
Rheumatoid nodule 277.95 10.90 461 550918 16977 79176032
Frequent bowel movements 276.20 10.90 623 550756 28916 79164093
Asthenia 276.12 10.90 2239 549140 509450 78683559
Maternal exposure during pregnancy 275.95 10.90 1752 549627 134786 79058223
Abdominal adhesions 274.92 10.90 215 551164 3358 79189651
Cardiac failure congestive 272.97 10.90 350 551029 142052 79050957
Cardiac failure 271.35 10.90 406 550973 154436 79038573
Uveitis 271.04 10.90 447 550932 16383 79176626
Mental status changes 270.51 10.90 65 551314 66894 79126115
Orthostatic hypotension 269.22 10.90 35 551344 56129 79136880
Joint range of motion decreased 266.74 10.90 661 550718 32621 79160388
Fistula 266.39 10.90 385 550994 12555 79180454
Injection site papule 263.24 10.90 129 551250 809 79192200
Syncope 262.97 10.90 527 550852 178922 79014087
Sleep disorder due to general medical condition, insomnia type 262.70 10.90 779 550600 42777 79150232
Cognitive disorder 261.53 10.90 79 551300 69847 79123162
Pneumonia aspiration 260.92 10.90 70 551309 66897 79126112
Renal failure 260.16 10.90 632 550747 200336 78992673
Tenosynovitis 255.74 10.90 417 550962 15137 79177872
Fibromyalgia 253.51 10.90 998 550381 63342 79129667
Tuberculin test positive 253.45 10.90 201 551178 3207 79189802
Diarrhoea 252.45 10.90 4429 546950 876060 78316949
Blood pressure increased 251.14 10.90 694 550685 210666 78982343
Demyelination 250.15 10.90 293 551086 7730 79185279
Heart rate increased 248.07 10.90 281 551098 120443 79072566
Agranulocytosis 245 10.90 17 551362 45013 79147996
Impaired work ability 243.80 10.90 466 550913 19215 79173794
Muscle injury 242.81 10.90 814 550565 47747 79145262
Herpes zoster 238.53 10.90 1272 550107 91811 79101198
Unresponsive to stimuli 235.74 10.90 49 551330 55739 79137270
Blood bilirubin increased 231.62 10.90 84 551295 66148 79126861
Pain in extremity 229.88 10.90 3668 547711 360870 78832139
Intentional product misuse 226.04 10.90 195 551184 94970 79098039
Foot deformity 217.60 10.90 501 550878 23573 79169436
Oedema peripheral 215.83 10.90 953 550426 251335 78941674
Neuropathy peripheral 214.79 10.90 406 550973 140899 79052110
Small intestinal obstruction 213.67 10.90 537 550842 26735 79166274
Decreased appetite 212.86 10.90 1439 549940 340979 78852030
Drug specific antibody 212.80 10.90 163 551216 2465 79190544
Joint injury 211.86 10.90 584 550795 30751 79162258
Disseminated tuberculosis 209.91 10.90 197 551182 3986 79189023
Hypomagnesaemia 209.29 10.90 36 551343 46875 79146134
Palmar-plantar erythrodysaesthesia syndrome 208.95 10.90 4 551375 33130 79159879
Toxic epidermal necrolysis 208.43 10.90 30 551349 44551 79148458
Abscess intestinal 208.35 10.90 164 551215 2587 79190422
Sacroiliitis 208.25 10.90 187 551192 3567 79189442
Injection site pruritus 206.31 10.90 703 550676 41580 79151429
Pyoderma gangrenosum 205.17 10.90 194 551185 3964 79189045
Mucosal inflammation 205.00 10.90 135 551244 75445 79117564
Melaena 204.97 10.90 82 551297 60808 79132201
Intestinal resection 204.18 10.90 185 551194 3572 79189437
Hypervolaemia 203.66 10.90 27 551352 42663 79150346
Flushing 203.47 10.90 186 551193 88082 79104927
Panniculitis 202.49 10.90 331 551048 12040 79180969
Small intestinal stenosis 202.46 10.90 104 551275 731 79192278
Rheumatic fever 199.21 10.90 538 550841 27987 79165022
Heart rate decreased 197.02 10.90 121 551258 70195 79122814
Chest discomfort 196.61 10.90 412 550967 137632 79055377
Pulmonary oedema 196.36 10.90 192 551187 88062 79104947
Joint effusion 193.65 10.90 402 550977 17612 79175397
Musculoskeletal disorder 192.37 10.90 445 550934 21003 79172006
Abscess 191.54 10.90 463 550916 22488 79170521
Intestinal fistula 191.33 10.90 121 551258 1317 79191692
Device issue 191.04 10.90 513 550866 26595 79166414
Hidradenitis 189.68 10.90 162 551217 2882 79190127
Cholestasis 189.27 10.90 62 551317 52047 79140962
Blood creatine phosphokinase increased 189.00 10.90 111 551268 65979 79127030
Polyarthritis 187.03 10.90 317 551062 11885 79181124
Blood parathyroid hormone decreased 186.29 10.90 292 551087 10244 79182765
Aggression 186.20 10.90 60 551319 50898 79142111
Granuloma skin 186.00 10.90 271 551108 8903 79184106
Plasma cell myeloma 183.78 10.90 69 551310 53190 79139819
Neurotoxicity 183.75 10.90 10 551369 32508 79160501
Musculoskeletal pain 183.55 10.90 1275 550104 101079 79091930
Disorientation 182.99 10.90 103 551276 62673 79130336
Blister 181.65 10.90 1431 549948 118045 79074964
Balance disorder 181.24 10.90 251 551128 98606 79094403
Drug level increased 180.07 10.90 29 551350 39622 79153387
Adverse event 176.77 10.90 855 550524 59359 79133650
Intentional dose omission 176.66 10.90 259 551120 8558 79184451
Drug tolerance decreased 176.65 10.90 320 551059 12658 79180351
Acute respiratory failure 174.56 10.90 97 551282 59444 79133565
Injection site swelling 173.61 10.90 716 550663 46416 79146593
Condition aggravated 172.44 10.90 4610 546769 496514 78696495
Basal cell carcinoma 172.44 10.90 610 550769 36765 79156244
Nodule 172.08 10.90 445 550934 22549 79170460
Hepatic failure 171.96 10.90 105 551274 61107 79131902
Bone marrow failure 171.74 10.90 69 551310 51038 79141971
Upper gastrointestinal haemorrhage 171.46 10.90 38 551341 41342 79151667
Sepsis 171.01 10.90 1125 550254 268303 78924706
Gastrointestinal wall thickening 170.89 10.90 144 551235 2513 79190496
Ventricular tachycardia 170.78 10.90 40 551339 41895 79151114
Blood pressure systolic increased 170.65 10.90 128 551251 66858 79126151
Cardiogenic shock 170.65 10.90 40 551339 41874 79151135
Respiratory distress 169.65 10.90 96 551283 58243 79134766
Drug eruption 169.43 10.90 677 550702 43258 79149751
Inflammatory bowel disease 168.95 10.90 202 551177 5449 79187560
Lethargy 168.31 10.90 188 551191 81104 79111905
Drug withdrawal syndrome 167.93 10.90 21 551358 34697 79158312
Paradoxical psoriasis 167.89 10.90 64 551315 190 79192819
Product use issue 167.69 10.90 2201 549178 207621 78985388
Restlessness 167.66 10.90 56 551323 46436 79146573
Dysphagia 166.89 10.90 373 551006 121763 79071246
Psychotic disorder 165.64 10.90 41 551338 41361 79151648
Myelosuppression 164.97 10.90 38 551341 40258 79152751
Dyspnoea exertional 162.73 10.90 218 551161 86855 79106154
Pulmonary arterial hypertension 162.57 10.90 8 551371 28358 79164651
Dysarthria 161.26 10.90 138 551241 67484 79125525
Hallucination, visual 160.27 10.90 19 551360 32710 79160299
Pulmonary hypertension 158.19 10.90 67 551312 48013 79144996
Blood glucose increased 158.02 10.90 350 551029 114625 79078384
Injection site urticaria 158.01 10.90 303 551076 12523 79180486
Ileostomy 157.84 10.90 115 551264 1605 79191404
Respiratory depression 157.69 10.90 8 551371 27622 79165387
Altered state of consciousness 157.65 10.90 53 551326 43769 79149240
Subdural haematoma 157.06 10.90 17 551362 31417 79161592
Delirium 157.02 10.90 213 551166 84414 79108595
Immunodeficiency 155.47 10.90 414 550965 21354 79171655
Infusion related reaction 154.98 10.90 2343 549036 227894 78965115
Swollen joint count increased 152.72 10.90 425 550954 22502 79170507
Full blood count abnormal 152.66 10.90 45 551334 40429 79152580
Joint destruction 151.80 10.90 196 551183 5729 79187280
Labelled drug-drug interaction medication error 151.71 10.90 10 551369 27640 79165369
Intestinal fibrosis 151.13 10.90 54 551325 125 79192884
Shock 150.96 10.90 56 551323 43492 79149517
Tumour lysis syndrome 150.52 10.90 3 551376 23936 79169073
Ulcer 150.34 10.90 503 550876 29469 79163540
Obstructive airways disorder 149.82 10.90 20 551359 31439 79161570
Accidental overdose 149.30 10.90 44 551335 39537 79153472
Product use in unapproved indication 148.65 10.90 1066 550313 249293 78943716
Haematemesis 147.73 10.90 89 551290 52175 79140834
Finger deformity 147.51 10.90 218 551161 7256 79185753
Osteoporosis 147.24 10.90 752 550627 53360 79139649
Pleural effusion 144.94 10.90 516 550863 144746 79048263
Ill-defined disorder 144.78 10.90 864 550515 65011 79127998
Lymphocyte count decreased 144.57 10.90 73 551306 47216 79145793
Angioedema 144.51 10.90 188 551191 75847 79117162
Therapeutic response decreased 143.85 10.90 872 550507 65981 79127028
Haemoglobin decreased 143.68 10.90 922 550457 221197 78971812
Grip strength decreased 143.32 10.90 403 550976 21466 79171543
Inappropriate antidiuretic hormone secretion 142.95 10.90 10 551369 26303 79166706
Device expulsion 142.94 10.90 9 551370 25852 79167157
Abnormal behaviour 142.00 10.90 38 551341 36383 79156626
Colectomy 141.44 10.90 144 551235 3230 79189779
Leukopenia 140.99 10.90 379 551000 116134 79076875
Blood cholesterol increased 140.85 10.90 1027 550352 82693 79110316
Urinary retention 140.70 10.90 111 551268 56519 79136490
Myoclonus 140.68 10.90 14 551365 27646 79165363
Status epilepticus 140.57 10.90 8 551371 25033 79167976
Dyskinesia 140.09 10.90 67 551312 44706 79148303
Stevens-Johnson syndrome 139.80 10.90 48 551331 39118 79153891
Cough 139.64 10.90 1744 549635 365045 78827964
COVID-19 139.61 10.90 1686 549693 155988 79037021
Acute hepatic failure 139.07 10.90 21 551358 30092 79162917
Malignant melanoma 139.02 10.90 312 551067 14429 79178580
Sinus bradycardia 138.91 10.90 9 551370 25238 79167771
Disseminated intravascular coagulation 138.61 10.90 38 551341 35804 79157205
Fear of injection 137.54 10.90 211 551168 7263 79185746
Osteonecrosis of jaw 134.76 10.90 65 551314 43161 79149848
Cerebral haemorrhage 134.73 10.90 120 551259 57553 79135456
Apparent death 134.40 10.90 130 551249 2735 79190274
Intestinal anastomosis complication 133.83 10.90 58 551321 261 79192748
Arrhythmia 133.20 10.90 136 551243 61136 79131873
Hepatocellular injury 133.19 10.90 82 551297 47511 79145498
Haematoma 132.61 10.90 100 551279 52095 79140914
Arthrodesis 131.74 10.90 119 551260 2288 79190721
Surgical failure 130.54 10.90 79 551300 790 79192219
Stomatitis 129.81 10.90 1569 549810 145188 79047821
Acute myocardial infarction 129.16 10.90 208 551171 76828 79116181
Product dose omission issue 128.72 10.90 1093 550286 246444 78946565
Pulmonary embolism 128.36 10.90 680 550699 170974 79022035
Joint dislocation 127.97 10.90 329 551050 16610 79176399
Tachypnoea 127.79 10.90 32 551347 32031 79160978
Neutropenic sepsis 127.01 10.90 18 551361 27046 79165963
Dysgeusia 126.48 10.90 125 551254 57052 79135957
Jaundice 125.84 10.90 110 551269 53239 79139770
Poisoning 125.42 10.90 14 551365 25258 79167751
IgA nephropathy 124.51 10.90 101 551278 1667 79191342
Therapy non-responder 124.41 10.90 1076 550303 91229 79101780
Pulmonary fibrosis 124.21 10.90 619 550760 43493 79149516
Intentional self-injury 124.19 10.90 35 551344 32384 79160625
Haemorrhage intracranial 121.57 10.90 18 551361 26175 79166834
Skin ulcer 121.42 10.90 714 550665 53436 79139573
Blood alkaline phosphatase increased 121.40 10.90 157 551222 63507 79129502
Thrombotic microangiopathy 121.27 10.90 4 551375 20165 79172844
Hyperbilirubinaemia 120.63 10.90 14 551365 24504 79168505
Anal abscess 120.19 10.90 225 551154 9130 79183879
Injection site bruising 120.19 10.90 582 550797 40420 79152589
Diabetic ketoacidosis 119.76 10.90 43 551336 34079 79158930
Generalised tonic-clonic seizure 119.65 10.90 78 551301 43832 79149177
Torsade de pointes 119.16 10.90 3 551376 19309 79173700
Anal stenosis 119.07 10.90 61 551318 426 79192583
Withdrawal syndrome 118.93 10.90 21 551358 26833 79166176
Intestinal mucosal hypertrophy 118.77 10.90 55 551324 298 79192711
Dermatitis psoriasiform 118.50 10.90 120 551259 2674 79190335
Intestinal anastomosis 117.91 10.90 68 551311 617 79192392
Synovial cyst 116.96 10.90 232 551147 9833 79183176
Abdominal abscess 115.71 10.90 190 551189 6937 79186072
Circulatory collapse 115.37 10.90 58 551321 37610 79155399
Blood pressure diastolic decreased 115.05 10.90 33 551346 30183 79162826
Nausea 115.01 10.90 5430 545949 951766 78241243
Mycobacterium tuberculosis complex test positive 114.93 10.90 118 551261 2674 79190335
Fluid retention 114.69 10.90 191 551188 69618 79123391
Antinuclear antibody positive 114.40 10.90 200 551179 7690 79185319
Disturbance in attention 113.59 10.90 110 551269 50691 79142318
Septic shock 113.52 10.90 450 550929 122351 79070658
Dermatitis allergic 112.88 10.90 328 551051 17802 79175207
Furuncle 111.50 10.90 193 551186 7361 79185648
Palmoplantar pustulosis 111.49 10.90 62 551317 521 79192488
Extrapyramidal disorder 111.46 10.90 13 551366 22666 79170343
Coagulopathy 110.94 10.90 55 551324 35951 79157058
Pancreatitis acute 110.23 10.90 108 551271 49496 79143513
Creatinine renal clearance decreased 110.06 10.90 5 551374 18997 79174012
Oral mucosal exfoliation 109.18 10.90 87 551292 1398 79191611
Allergic oedema 108.86 10.90 68 551311 723 79192286
Skin plaque 108.78 10.90 234 551145 10511 79182498
Blood pressure fluctuation 108.20 10.90 186 551193 66959 79126050
Ejection fraction decreased 107.78 10.90 52 551327 34525 79158484
Blood urea increased 107.53 10.90 107 551272 48683 79144326
Delusion 107.45 10.90 9 551370 20414 79172595
Ascites 107.15 10.90 226 551153 75336 79117673
Rheumatoid lung 106.53 10.90 139 551240 4106 79188903
Adverse reaction 106.21 10.90 213 551166 9101 79183908
Joint arthroplasty 105.97 10.90 112 551267 2628 79190381
Dystonia 105.83 10.90 12 551367 21387 79171622
Poisoning deliberate 105.73 10.90 6 551373 18822 79174187
Physical disability 105.42 10.90 122 551257 3176 79189833
Anxiety 105.18 10.90 1154 550225 247358 78945651
Acute respiratory distress syndrome 104.98 10.90 90 551289 43977 79149032
Hepatic cytolysis 104.59 10.90 29 551350 27122 79165887
Haemodialysis 104.51 10.90 5 551374 18163 79174846
Fine motor skill dysfunction 103.92 10.90 155 551224 5202 79187807
Off label use 102.15 10.90 5181 546198 902034 78290975
Dactylitis 101.87 10.90 110 551269 2647 79190362
Colitis ulcerative 101.73 10.90 493 550886 34249 79158760
Deformity 101.66 10.90 213 551166 9392 79183617
Loss of consciousness 101.62 10.90 711 550668 167232 79025777
Faecal calprotectin increased 101.36 10.90 156 551223 5385 79187624
Sciatica 100.58 10.90 476 550903 32746 79160263
Fistula discharge 100.27 10.90 80 551299 1288 79191721
Inflammatory marker increased 99.81 10.90 226 551153 10514 79182495
Product administration error 99.10 10.90 48 551331 31798 79161211
Gamma-glutamyltransferase increased 99.04 10.90 140 551239 54540 79138469
Injection site rash 98.79 10.90 311 551068 17643 79175366
Chest pain 98.32 10.90 1367 550012 280937 78912072
Respiratory rate increased 97.63 10.90 16 551363 21584 79171425
Lymphoma 97.50 10.90 304 551075 17156 79175853
Sinus tachycardia 97.30 10.90 68 551311 36840 79156169
Full blood count decreased 97.23 10.90 32 551347 26787 79166222
Rash maculo-papular 96.29 10.90 149 551230 55929 79137080
Shoulder arthroplasty 95.96 10.90 116 551263 3166 79189843
Rectal stenosis 95.78 10.90 48 551331 318 79192691
Miosis 95.40 10.90 3 551376 15786 79177223
Musculoskeletal deformity 95.31 10.90 82 551297 1474 79191535
Skin necrosis 94.69 10.90 308 551071 17779 79175230
Hepatic encephalopathy 94.62 10.90 25 551354 24141 79168868
Hypocalcaemia 94.28 10.90 124 551255 49800 79143209
Suicidal ideation 93.34 10.90 247 551132 76093 79116916
Intestinal dilatation 93.30 10.90 104 551275 2596 79190413
Haemoptysis 93.12 10.90 152 551227 55847 79137162
Immunosuppression 92.95 10.90 245 551134 12558 79180451
Joint laxity 92.77 10.90 97 551282 2247 79190762
Intervertebral disc protrusion 92.69 10.90 366 551013 23255 79169754
Right ventricular failure 92.59 10.90 24 551355 23473 79169536
Contrast media allergy 92.10 10.90 100 551279 2422 79190587
Hypothermia 92.02 10.90 22 551357 22724 79170285
Gastrooesophageal reflux disease 91.97 10.90 389 550990 103857 79089152
Haematuria 91.76 10.90 213 551166 68623 79124386
Urinary incontinence 90.98 10.90 89 551290 40820 79152189
Limb deformity 90.79 10.90 118 551261 3472 79189537
Type 2 diabetes mellitus 90.55 10.90 691 550688 56431 79136578
Bursitis 90.53 10.90 488 550891 35356 79157653
Body height below normal 90.42 10.90 90 551289 1963 79191046
Alanine aminotransferase abnormal 89.65 10.90 193 551186 8674 79184335
Human antichimeric antibody positive 89.56 10.90 81 551298 1560 79191449
Eosinophilia 89.40 10.90 109 551270 45236 79147773
Muscle rigidity 89.25 10.90 15 551364 19867 79173142
Posterior reversible encephalopathy syndrome 89.09 10.90 35 551344 26246 79166763
Speech disorder 88.47 10.90 150 551229 54295 79138714
Pneumonia 88.40 10.90 3700 547679 656546 78536463
Electrolyte imbalance 88.10 10.90 52 551327 30829 79162180
Ventricular fibrillation 87.96 10.90 56 551323 31870 79161139
Iridocyclitis 87.88 10.90 118 551261 3586 79189423
Ear infection 87.11 10.90 469 550910 33963 79159046
Graft versus host disease 86.88 10.90 4 551375 15022 79177987
Muscle spasticity 86.43 10.90 21 551358 21454 79171555
Neck pain 86.38 10.90 849 550530 74568 79118441
Injection site warmth 85.65 10.90 261 551118 14546 79178463
Deep vein thrombosis 85.44 10.90 488 550891 120431 79072578
Live birth 84.81 10.90 304 551075 18440 79174569
Bronchitis chronic 84.55 10.90 128 551251 4354 79188655
Irritability 84.23 10.90 96 551283 41048 79151961
Pruritus allergic 84.22 10.90 73 551306 1326 79191683
Gastric disorder 84.19 10.90 494 550885 36939 79156070
Chronic kidney disease 83.99 10.90 210 551169 65944 79127065
X-ray abnormal 83.82 10.90 147 551232 5666 79187343
Anhedonia 82.89 10.90 5 551374 14893 79178116
Pulmonary tuberculosis 82.76 10.90 174 551205 7691 79185318
Anaphylactic shock 82.76 10.90 76 551303 35920 79157089
Cytomegalovirus infection 82.51 10.90 104 551275 42540 79150469
Epistaxis 82.09 10.90 444 550935 111071 79081938
Anastomotic stenosis 82.07 10.90 49 551330 477 79192532
Gastrointestinal scarring 82.01 10.90 43 551336 317 79192692
Angina pectoris 81.81 10.90 145 551234 51587 79141422
Salivary hypersecretion 81.55 10.90 4 551375 14220 79178789
Cutaneous T-cell lymphoma 81.43 10.90 97 551282 2606 79190403
Foot operation 81.41 10.90 144 551235 5589 79187420
Myalgia 81.36 10.90 855 550524 184786 79008223
Product quality issue 81.24 10.90 69 551310 33871 79159138
Gastrointestinal fistula 81.17 10.90 56 551323 713 79192296
Blood pressure diastolic abnormal 80.84 10.90 17 551362 19185 79173824
Palpitations 80.57 10.90 528 550851 126082 79066927
Nephropathy toxic 80.18 10.90 21 551358 20398 79172611
Gait inability 80.00 10.90 688 550691 58229 79134780
Shock haemorrhagic 79.98 10.90 20 551359 20040 79172969
Coronary artery disease 79.93 10.90 212 551167 65262 79127747
Atrial flutter 79.82 10.90 25 551354 21600 79171409
Blood potassium increased 79.77 10.90 52 551327 29223 79163786
Nasal congestion 79.66 10.90 267 551112 76285 79116724
Mania 79.31 10.90 15 551364 18245 79174764
Red blood cell sedimentation rate 79.31 10.90 140 551239 5425 79187584
Haemorrhage 79.15 10.90 342 551037 90776 79102233
Bone pain 78.79 10.90 167 551212 55575 79137434
Haemodynamic instability 78.28 10.90 13 551366 17369 79175640
Gastrointestinal mucosa hyperaemia 77.81 10.90 46 551333 439 79192570
Mydriasis 77.69 10.90 14 551365 17629 79175380
Pallor 77.66 10.90 142 551237 49920 79143089
Renal tubular necrosis 77.52 10.90 38 551341 25001 79168008
Blood lactate dehydrogenase increased 77.39 10.90 94 551285 39076 79153933
Gastrointestinal stoma complication 76.77 10.90 93 551286 2544 79190465
Second primary malignancy 76.40 10.90 6 551373 14344 79178665
Dialysis 76.39 10.90 17 551362 18445 79174564
Acidosis 76.32 10.90 21 551358 19741 79173268
Epicondylitis 75.44 10.90 84 551295 2094 79190915
Blood pressure systolic abnormal 75.27 10.90 14 551365 17233 79175776
Deafness transitory 74.67 10.90 59 551320 936 79192073
Pneumonitis 74.34 10.90 197 551182 60663 79132346
Oliguria 73.89 10.90 12 551367 16297 79176712
Sarcoidosis 73.71 10.90 172 551207 8163 79184846
Presyncope 73.48 10.90 106 551273 40948 79152061
Renal injury 73.32 10.90 14 551365 16913 79176096
Lymphopenia 73.29 10.90 62 551317 30495 79162514
Cutaneous leishmaniasis 72.83 10.90 38 551341 277 79192732
Hallucination, auditory 72.75 10.90 26 551353 20667 79172342
Cytopenia 72.71 10.90 25 551354 20358 79172651
Endometriosis 72.40 10.90 107 551272 3561 79189448
Bacteraemia 72.32 10.90 72 551307 32752 79160257
Blood sodium decreased 72.06 10.90 74 551305 33181 79159828
Small intestinal resection 71.58 10.90 56 551323 875 79192134
Gastrointestinal stenosis 71.48 10.90 35 551344 219 79192790
Injection site hypersensitivity 71.47 10.90 77 551302 1848 79191161
Gastrointestinal obstruction 71.33 10.90 74 551305 1698 79191311
Intestinal ulcer 71.28 10.90 79 551300 1959 79191050
Parkinsonism 71.24 10.90 14 551365 16570 79176439
Antinuclear antibody increased 71.13 10.90 62 551317 1135 79191874
Loose body in joint 70.83 10.90 64 551315 1231 79191778
Hyperhidrosis 70.81 10.90 687 550692 150805 79042204
Cerebrovascular accident 70.59 10.90 709 550670 154583 79038426
Spinal instability 70.25 10.90 42 551337 410 79192599
Infusion site pain 69.98 10.90 8 551371 14168 79178841
Pulseless electrical activity 69.88 10.90 8 551371 14152 79178857
Body temperature increased 69.79 10.90 125 551254 44295 79148714
Pulmonary mass 69.78 10.90 390 550989 28644 79164365
Cerebral infarction 69.57 10.90 131 551248 45545 79147464
Guttate psoriasis 68.98 10.90 42 551337 425 79192584
Chondropathy 68.95 10.90 86 551293 2426 79190583
Investigation abnormal 68.69 10.90 78 551301 1988 79191021
Aphasia 68.60 10.90 137 551242 46595 79146414
Hypophosphataemia 68.36 10.90 26 551353 19887 79173122
Atlantoaxial instability 68.26 10.90 36 551343 269 79192740
Hyperlipidaemia 67.56 10.90 49 551330 26044 79166965
Tendonitis 67.51 10.90 335 551044 23495 79169514
Pericardial effusion 67.49 10.90 136 551243 46101 79146908
Chills 67.38 10.90 745 550634 159489 79033520
Iritis 66.99 10.90 106 551273 3749 79189260
Mineral metabolism disorder 66.74 10.90 36 551343 283 79192726
Lymphadenopathy 66.73 10.90 611 550768 52636 79140373
Lower respiratory tract infection 66.38 10.90 1259 550120 127961 79065048
Inflammatory pain 66.09 10.90 56 551323 985 79192024
Progressive multifocal leukoencephalopathy 65.72 10.90 30 551349 20570 79172439
Paranoia 65.67 10.90 26 551353 19406 79173603
Product substitution issue 65.58 10.90 296 551083 19960 79173049
Acute generalised exanthematous pustulosis 65.40 10.90 19 551360 17235 79175774
Blood calcium decreased 65.40 10.90 74 551305 31745 79161264
Atrioventricular block complete 65.38 10.90 17 551362 16593 79176416
Henoch-Schonlein purpura 65.32 10.90 87 551292 2623 79190386
Transfusion 65.09 10.90 33 551346 21297 79171712
Device defective 64.71 10.90 73 551306 1847 79191162
Hypovolaemia 64.33 10.90 21 551358 17670 79175339
Transplant rejection 64.07 10.90 27 551352 19410 79173599
Onychomycosis 64.01 10.90 162 551217 8099 79184910
Bronchospasm 63.95 10.90 47 551332 24812 79168197
Blood pressure systolic decreased 63.87 10.90 3 551376 11073 79181936
Defaecation urgency 63.81 10.90 131 551248 5693 79187316
Productive cough 63.74 10.90 354 551025 87977 79105032
Ataxia 63.57 10.90 48 551331 24991 79168018
Pneumonia legionella 63.18 10.90 89 551290 2833 79190176
Toxic encephalopathy 63.17 10.90 4 551375 11436 79181573
Spinal stenosis 63.03 10.90 246 551133 15545 79177464
Dislocation of vertebra 62.60 10.90 156 551223 7724 79185285
Foetal death 62.59 10.90 158 551221 7886 79185123
Intestinal sepsis 62.56 10.90 51 551328 848 79192161
Lower gastrointestinal haemorrhage 62.53 10.90 17 551362 16108 79176901
Blood iron abnormal 62.20 10.90 61 551318 1306 79191703
Wrist deformity 62.18 10.90 75 551304 2042 79190967
Diverticulitis 62.14 10.90 536 550843 45400 79147609
Fistula of small intestine 61.98 10.90 49 551330 778 79192231
Blood glucose decreased 61.98 10.90 54 551325 26180 79166829
Heart rate irregular 61.88 10.90 81 551298 32598 79160411
Ankle operation 61.81 10.90 55 551324 1036 79191973
Food intolerance 61.68 10.90 102 551277 3746 79189263
Incorrect dose administered 61.61 10.90 805 550574 75825 79117184
Body temperature decreased 61.56 10.90 79 551300 32066 79160943
Meniscus injury 61.32 10.90 141 551238 6627 79186382
Pyrexia 61.29 10.90 3958 547421 674751 78518258
Urine output decreased 61.09 10.90 24 551355 17998 79175011
Neoplasm malignant 61.02 10.90 403 550976 31407 79161602
Myopathy 60.99 10.90 33 551346 20530 79172479
Cervical dysplasia 60.94 10.90 75 551304 2086 79190923
No adverse event 60.86 10.90 102 551277 37090 79155919
Chromaturia 60.82 10.90 53 551326 25693 79167316
Limb operation 60.64 10.90 95 551284 3331 79189678
Electrocardiogram abnormal 60.62 10.90 20 551359 16717 79176292
Post transplant lymphoproliferative disorder 60.45 10.90 5 551374 11459 79181550
Wheelchair user 60.32 10.90 132 551247 6000 79187009
Mental impairment 60.30 10.90 28 551351 19008 79174001
Pharyngitis streptococcal 60.25 10.90 187 551192 10527 79182482
Substance abuse 60.22 10.90 3 551376 10523 79182486
Ileal ulcer 60.15 10.90 55 551324 1075 79191934
Ileostomy closure 59.87 10.90 33 551346 272 79192737
Prothrombin time prolonged 59.81 10.90 21 551358 16878 79176131
Urticaria 59.58 10.90 1690 549689 183511 79009498
Premature delivery 59.56 10.90 45 551334 23422 79169587
Cyanosis 59.29 10.90 52 551327 25130 79167879
Coeliac disease 59.16 10.90 193 551186 11158 79181851
Hospice care 58.88 10.90 3 551376 10321 79182688
C-reactive protein decreased 58.78 10.90 82 551297 2586 79190423
COVID-19 pneumonia 58.31 10.90 68 551311 28781 79164228
Metastases to bone 58.05 10.90 50 551329 24377 79168632
Rheumatic disorder 57.89 10.90 89 551290 3069 79189940
Leukocytosis 57.48 10.90 135 551244 43320 79149689
Infusion site extravasation 57.45 10.90 3 551376 10105 79182904
Exostosis 57.34 10.90 250 551129 16608 79176401
Anticipatory anxiety 57.17 10.90 55 551324 1149 79191860
Hypothyroidism 57.10 10.90 179 551200 52213 79140796
Device related infection 57.09 10.90 93 551286 34201 79158808
Exposure during pregnancy 57.08 10.90 1000 550379 100132 79092877
Vision blurred 57.07 10.90 463 550916 105435 79087574
Enterocutaneous fistula 56.83 10.90 69 551310 1892 79191117
Diarrhoea haemorrhagic 56.80 10.90 211 551168 13023 79179986
Nail disorder 56.01 10.90 195 551184 11657 79181352
Wheezing 55.81 10.90 526 550853 116138 79076871
Bone density decreased 55.79 10.90 211 551168 13136 79179873
Colitis 55.59 10.90 762 550617 72545 79120464
Gastrointestinal oedema 55.51 10.90 79 551300 2539 79190470
Hepatosplenic T-cell lymphoma 55.27 10.90 47 551332 831 79192178
Systemic infection 55.10 10.90 3 551376 9749 79183260
Chronic obstructive pulmonary disease 54.95 10.90 355 551024 85064 79107945
Acute graft versus host disease 54.84 10.90 4 551375 10163 79182846
Medication error 54.64 10.90 266 551113 68376 79124633
Tonsillitis 54.48 10.90 134 551245 6580 79186429
Rectal discharge 54.47 10.90 45 551334 763 79192246
Amyotrophic lateral sclerosis 54.46 10.90 65 551314 1750 79191259
Intestinal perforation 54.45 10.90 252 551127 17174 79175835
Angina unstable 54.41 10.90 23 551356 16504 79176505
Anti-cyclic citrullinated peptide antibody 54.22 10.90 123 551256 5729 79187280
Muscle twitching 53.78 10.90 55 551324 24709 79168300
Double stranded DNA antibody positive 53.76 10.90 36 551343 435 79192574
Female genital tract fistula 53.61 10.90 124 551255 5851 79187158
Secretion discharge 53.58 10.90 226 551153 14796 79178213
Ovarian neoplasm 53.56 10.90 40 551339 581 79192428
Injection site irritation 53.56 10.90 95 551284 3695 79189314
Subarachnoid haemorrhage 53.51 10.90 54 551325 24411 79168598
Enterocolonic fistula 53.46 10.90 25 551354 139 79192870
Rectal abscess 53.46 10.90 70 551309 2075 79190934
Axial spondyloarthritis 53.37 10.90 39 551340 547 79192462
Infusion site erythema 53.17 10.90 3 551376 9457 79183552
Ileectomy 53.13 10.90 27 551352 185 79192824
Psychomotor hyperactivity 53.03 10.90 25 551354 16824 79176185
Kidney transplant rejection 52.59 10.90 5 551374 10241 79182768
Subileus 52.57 10.90 119 551260 5535 79187474
Bradyphrenia 52.53 10.90 6 551373 10634 79182375
Abdominal lymphadenopathy 52.43 10.90 55 551324 1279 79191730
Anuria 52.18 10.90 41 551338 20922 79172087
Spinal column injury 52.12 10.90 70 551309 2128 79190881
Cartilage atrophy 52.05 10.90 25 551354 149 79192860
Gastrointestinal infection 51.95 10.90 186 551193 11275 79181734
Intervertebral disc space narrowing 51.84 10.90 62 551317 1673 79191336
Proctitis 51.79 10.90 128 551251 6304 79186705
Heparin-induced thrombocytopenia 51.68 10.90 4 551375 9678 79183331
Schizophrenia 51.62 10.90 21 551358 15419 79177590
Retinitis 51.61 10.90 118 551261 5525 79187484
Eosinophil count increased 51.40 10.90 27 551352 17078 79175931
Lymph node tuberculosis 51.35 10.90 48 551331 966 79192043
Sudden death 51.19 10.90 48 551331 22463 79170546
Acute myeloid leukaemia 51.19 10.90 84 551295 30801 79162208
Throat irritation 51.18 10.90 131 551248 40815 79152194
Coordination abnormal 51.03 10.90 28 551351 17284 79175725
Spinal operation 51.00 10.90 145 551234 7772 79185237
Transient ischaemic attack 50.67 10.90 190 551189 52505 79140504
Haemolysis 50.64 10.90 13 551366 12799 79180210
Hepatitis acute 50.58 10.90 22 551357 15520 79177489
Granulocytopenia 50.49 10.90 9 551370 11422 79181587
Post procedural complication 50.09 10.90 309 551070 23520 79169489
DNA antibody positive 50.08 10.90 30 551349 294 79192715
Tardive dyskinesia 49.68 10.90 7 551372 10564 79182445
Liver function test increased 49.64 10.90 456 550923 39317 79153692
Aspergillus infection 49.59 10.90 36 551343 19125 79173884
Joint ankylosis 49.52 10.90 68 551311 2112 79190897
Aspiration 49.46 10.90 40 551339 20118 79172891
Haemolytic anaemia 49.44 10.90 31 551348 17789 79175220
B-cell lymphoma 49.33 10.90 123 551256 6092 79186917
Blood loss anaemia 48.77 10.90 23 551356 15475 79177534
Latent tuberculosis 48.62 10.90 85 551294 3268 79189741
Colonic fistula 48.62 10.90 39 551340 633 79192376
Papilloma viral infection 48.61 10.90 60 551319 1674 79191335
Pouchitis 48.52 10.90 46 551333 943 79192066
Maternal exposure timing unspecified 48.49 10.90 117 551262 5675 79187334
Asthma 48.47 10.90 650 550729 134445 79058564
Histoplasmosis disseminated 48.42 10.90 70 551309 2283 79190726
Faecal calprotectin abnormal 48.28 10.90 25 551354 179 79192830
Spondyloarthropathy 48.24 10.90 47 551332 998 79192011
Gastrointestinal pain 48.19 10.90 164 551215 9691 79183318
Arthritis bacterial 47.90 10.90 156 551223 9010 79183999
Procedural intestinal perforation 47.61 10.90 26 551353 210 79192799
Hepatic cirrhosis 47.58 10.90 408 550971 34498 79158511
Dysuria 47.52 10.90 186 551193 50765 79142244
Alanine aminotransferase increased 47.44 10.90 814 550565 161756 79031253
Rash pruritic 47.36 10.90 727 550652 70902 79122107
Osteoporotic fracture 47.20 10.90 96 551283 4144 79188865
Nightmare 47.04 10.90 66 551313 25795 79167214
Postoperative wound infection 47.01 10.90 196 551183 12765 79180244
Respiratory acidosis 46.98 10.90 10 551369 11190 79181819
Tonsillar ulcer 46.94 10.90 32 551347 399 79192610
Granuloma 46.83 10.90 145 551234 8152 79184857
Sleep disorder due to a general medical condition 46.79 10.90 20 551359 14257 79178752
Breast cancer stage III 46.72 10.90 162 551217 9664 79183345
Steroid dependence 46.65 10.90 73 551306 2557 79190452
Product monitoring error 46.65 10.90 4 551375 8902 79184107
Blood lactic acid increased 46.56 10.90 15 551364 12729 79180280
Cholangitis sclerosing 46.50 10.90 73 551306 2564 79190445
Brain oedema 46.43 10.90 64 551315 25199 79167810
Diabetes mellitus inadequate control 46.09 10.90 60 551319 24204 79168805
Precancerous cells present 46.08 10.90 49 551330 1158 79191851
Hepatitis cholestatic 46.05 10.90 19 551360 13833 79179176
BK virus infection 45.99 10.90 4 551375 8800 79184209
Joint lock 45.79 10.90 81 551298 3144 79189865
Hypovolaemic shock 45.65 10.90 14 551365 12262 79180747
Exposure to toxic agent 45.63 10.90 5 551374 9153 79183856
Skin toxicity 45.63 10.90 3 551376 8311 79184698
Appendicectomy 45.61 10.90 74 551305 2674 79190335
Vascular device infection 45.58 10.90 8 551371 10268 79182741
Spondylitis 45.58 10.90 101 551278 4630 79188379
Cardiac disorder 45.57 10.90 267 551112 65490 79127519
Terminal state 45.57 10.90 103 551276 4786 79188223
Myocardial ischaemia 45.56 10.90 66 551313 25453 79167556
Malaise 45.44 10.90 3955 547424 485914 78707095
Clostridium difficile colitis 45.39 10.90 97 551282 32186 79160823
Intestinal polyp 45.36 10.90 64 551315 2040 79190969
Coma scale abnormal 45.17 10.90 4 551375 8674 79184335
Pseudopolyp 45.12 10.90 32 551347 427 79192582
Onychomadesis 45.08 10.90 107 551272 5135 79187874
Rales 45.07 10.90 43 551336 19958 79173051
Loss of therapeutic response 45.06 10.90 42 551337 842 79192167
Dysphonia 44.91 10.90 221 551158 56651 79136358
Metastases to central nervous system 44.73 10.90 29 551350 16346 79176663
Emotional distress 44.66 10.90 135 551244 39834 79153175
Bronchopulmonary aspergillosis 44.57 10.90 53 551326 22241 79170768
Adhesion 44.54 10.90 51 551328 1312 79191697
Bloody discharge 44.49 10.90 61 551318 1892 79191117
Adjustment disorder with depressed mood 44.25 10.90 151 551228 8935 79184074
Supraventricular tachycardia 44.22 10.90 49 551330 21221 79171788
Postoperative adhesion 44.20 10.90 32 551347 442 79192567
Drug use disorder 44.10 10.90 146 551233 8505 79184504
Mucormycosis 43.83 10.90 4 551375 8465 79184544
Hypoaesthesia 43.67 10.90 1583 549796 177769 79015240
Lyme disease 43.57 10.90 81 551298 3269 79189740
Blood culture positive 43.57 10.90 4 551375 8425 79184584
End stage renal disease 43.57 10.90 15 551364 12205 79180804
Cholecystectomy 43.55 10.90 154 551225 9278 79183731
Neck mass 43.54 10.90 95 551284 4309 79188700
Dermatitis bullous 43.52 10.90 22 551357 14223 79178786
Nocturia 43.52 10.90 20 551359 13661 79179348
Cardiac failure acute 43.47 10.90 40 551339 18889 79174120
Activated partial thromboplastin time prolonged 43.43 10.90 22 551357 14206 79178803
Rotator cuff syndrome 43.43 10.90 203 551176 13892 79179117
Antibody test positive 43.41 10.90 73 551306 2719 79190290
Atrioventricular block first degree 43.40 10.90 16 551363 12475 79180534
Erythema multiforme 43.34 10.90 35 551344 17616 79175393
Memory impairment 43.27 10.90 529 550850 111205 79081804
Purulent discharge 43.27 10.90 115 551264 5924 79187085
Clinically isolated syndrome 43.12 10.90 15 551364 31 79192978
International normalised ratio fluctuation 43.04 10.90 82 551297 3372 79189637
Cytomegalovirus infection reactivation 42.82 10.90 5 551374 8711 79184298
Ecchymosis 42.82 10.90 26 551353 15180 79177829
Neck deformity 42.79 10.90 58 551321 1779 79191230
Hepatitis B virus test positive 42.72 10.90 32 551347 467 79192542
Ketoacidosis 42.62 10.90 3 551376 7851 79185158
Anorectal disorder 42.57 10.90 65 551314 2228 79190781
Pathogen resistance 42.56 10.90 23 551356 14319 79178690
Atrioventricular block 42.43 10.90 22 551357 14019 79178990
Pulse absent 42.42 10.90 9 551370 10094 79182915
Insomnia 42.39 10.90 1331 550048 243839 78949170
Forced expiratory volume decreased 42.36 10.90 3 551376 7811 79185198
Lip swelling 42.34 10.90 143 551236 40768 79152241
Aplasia pure red cell 42.33 10.90 3 551376 7807 79185202
Multiple fractures 42.31 10.90 137 551242 7889 79185120
Aspartate aminotransferase increased 42.14 10.90 689 550690 137952 79055057
Sensitivity to weather change 42.09 10.90 137 551242 7910 79185099
Scleritis 41.98 10.90 93 551286 4263 79188746
Obesity 41.97 10.90 399 550980 34726 79158283
Post procedural infection 41.96 10.90 173 551206 11211 79181798
Head injury 41.91 10.90 126 551253 37243 79155766
Dementia 41.87 10.90 66 551313 24593 79168416
Facet joint syndrome 41.85 10.90 172 551207 11130 79181879
Polyuria 41.82 10.90 26 551353 14988 79178021
Hypercapnia 41.79 10.90 6 551373 8929 79184080
Pollakiuria 41.73 10.90 126 551253 37191 79155818
Hypernatraemia 41.69 10.90 24 551355 14427 79178582
Seronegative arthritis 41.69 10.90 97 551282 4595 79188414
Pulmonary haemorrhage 41.67 10.90 25 551354 14692 79178317
Hyperthermia 41.56 10.90 38 551341 17999 79175010
Bradykinesia 41.09 10.90 4 551375 8039 79184970
Synovectomy 40.96 10.90 24 551355 225 79192784
Catatonia 40.68 10.90 6 551373 8750 79184259
Procedural pain 40.44 10.90 286 551093 22798 79170211
Troponin increased 40.43 10.90 44 551335 19211 79173798
Drug tolerance 40.36 10.90 142 551237 8533 79184476
Skin lesion 40.35 10.90 455 550924 41389 79151620
Antibiotic therapy 40.34 10.90 39 551340 820 79192189
Localised infection 40.13 10.90 417 550962 37158 79155851
Paradoxical drug reaction 40.03 10.90 125 551254 7060 79185949
Infusion site reaction 39.97 10.90 80 551299 3413 79189596
Petechiae 39.94 10.90 50 551329 20515 79172494
Enteritis 39.89 10.90 203 551176 14380 79178629
Erythema nodosum 39.88 10.90 103 551276 5214 79187795
Dizziness postural 39.78 10.90 15 551364 11534 79181475
Aplastic anaemia 39.76 10.90 39 551340 17866 79175143
Red cell distribution width decreased 39.58 10.90 59 551320 1979 79191030
Mass 39.56 10.90 231 551148 17241 79175768
Dyshidrotic eczema 39.44 10.90 33 551346 570 79192439
Face oedema 39.17 10.90 85 551294 28051 79164958
Acute pulmonary oedema 39.14 10.90 25 551354 14205 79178804
Ileocolectomy 39.03 10.90 13 551366 22 79192987
Ventricular arrhythmia 38.96 10.90 7 551372 8833 79184176
Joint warmth 38.93 10.90 52 551327 1572 79191437
Post procedural inflammation 38.79 10.90 19 551360 119 79192890
Pulmonary thrombosis 38.76 10.90 177 551202 11994 79181015
Metabolic encephalopathy 38.71 10.90 8 551371 9139 79183870
Arthroscopy 38.65 10.90 31 551348 503 79192506
Incisional hernia 38.65 10.90 65 551314 2421 79190588
Chronic recurrent multifocal osteomyelitis 38.58 10.90 16 551363 63 79192946
Stenosis 38.55 10.90 64 551315 2358 79190651
Histoplasmosis 38.33 10.90 63 551316 2302 79190707
Vein rupture 38.20 10.90 58 551321 1978 79191031
Tongue disorder 37.85 10.90 194 551185 13781 79179228
Colon dysplasia 37.75 10.90 22 551357 204 79192805
Ischaemic stroke 37.67 10.90 111 551268 33020 79159989
Oesophagitis 37.58 10.90 69 551310 24220 79168789
Asphyxia 37.49 10.90 17 551362 11703 79181306
Ileocaecal resection 37.38 10.90 18 551361 108 79192901
Abnormal dreams 37.38 10.90 16 551363 11396 79181613
Ageusia 37.19 10.90 36 551343 16596 79176413
Hypoxic-ischaemic encephalopathy 37.17 10.90 5 551374 7815 79185194
Mean platelet volume decreased 36.96 10.90 68 551311 2722 79190287
Multiple sclerosis 36.69 10.90 272 551107 22010 79170999
Retinal toxicity 36.65 10.90 47 551332 1364 79191645
Unevaluable event 36.30 10.90 563 550816 55022 79137987
Femur fracture 36.24 10.90 418 550961 38234 79154775
Deep vein thrombosis postoperative 36.22 10.90 159 551220 10593 79182416
Arthritis enteropathic 36.19 10.90 24 551355 285 79192724
Pulmonary alveolar haemorrhage 36.06 10.90 17 551362 11440 79181569
Large intestinal ulcer 36.06 10.90 93 551286 4704 79188305
Accidental exposure to product 35.57 10.90 105 551274 31217 79161792
Azotaemia 35.52 10.90 7 551372 8269 79184740
Sickle cell anaemia with crisis 35.51 10.90 6 551373 7916 79185093
Pneumonia bacterial 35.50 10.90 49 551330 19282 79173727
Knee operation 35.44 10.90 105 551274 5761 79187248
Thirst 35.40 10.90 46 551333 18573 79174436
Breast cancer 35.19 10.90 373 551006 33408 79159601
Abortion spontaneous 35.17 10.90 335 551044 29172 79163837
Feeling cold 35.07 10.90 93 551286 28636 79164373
Bone cyst 35.02 10.90 75 551304 3358 79189651
Blood glucose fluctuation 35 10.90 3 551376 6679 79186330
Toxic skin eruption 34.78 10.90 63 551316 22230 79170779
Injection site vesicles 34.72 10.90 70 551309 3002 79190007
Optic neuritis 34.56 10.90 144 551235 9376 79183633
Hyperthyroidism 34.44 10.90 63 551316 22146 79170863
Increased appetite 34.41 10.90 20 551359 11958 79181051
Lip dry 34.36 10.90 203 551176 15215 79177794
Subcutaneous abscess 34.34 10.90 127 551252 7822 79185187
Intestinal operation 34.32 10.90 29 551350 508 79192501
Hypoalbuminaemia 34.30 10.90 59 551320 21238 79171771
Blood pressure diastolic increased 34.27 10.90 30 551349 14512 79178497
Abscess rupture 34.24 10.90 24 551355 314 79192695
Electrocardiogram ST segment elevation 34.21 10.90 8 551371 8389 79184620
Device dislocation 34.09 10.90 81 551298 25889 79167120
Hot flush 33.82 10.90 231 551148 54646 79138363
Muscular weakness 33.80 10.90 849 550530 159880 79033129
Hallucinations, mixed 33.79 10.90 4 551375 6895 79186114
Cytology abnormal 33.73 10.90 24 551355 322 79192687
Personality change 33.73 10.90 14 551365 10156 79182853
Mucous stools 33.70 10.90 95 551284 5067 79187942
Stupor 33.62 10.90 4 551375 6868 79186141
Fear 33.53 10.90 63 551316 21923 79171086
Complication associated with device 33.50 10.90 43 551336 17453 79175556
Bundle branch block right 33.45 10.90 18 551361 11233 79181776
Brain natriuretic peptide increased 33.37 10.90 10 551369 8890 79184119
Depressive symptom 33.33 10.90 3 551376 6420 79186589
Spinal pain 33.24 10.90 201 551178 15191 79177818
Incorrect product administration duration 33.24 10.90 21 551358 12001 79181008
Peritoneal tuberculosis 33.21 10.90 28 551351 489 79192520
Rhinitis allergic 33.14 10.90 22 551357 12247 79180762
Haematochezia 33.12 10.90 817 550562 86828 79106181
Hepatic function abnormal 33.11 10.90 334 551045 72773 79120236
Hepatic enzyme abnormal 33.08 10.90 124 551255 7686 79185323
Blood creatine increased 33.04 10.90 12 551367 9443 79183566
Stress cardiomyopathy 33.00 10.90 18 551361 11148 79181861
Hodgkin's disease 32.99 10.90 35 551344 825 79192184
Enterocolitis 32.93 10.90 31 551348 14481 79178528
Therapeutic response shortened 32.90 10.90 205 551174 15658 79177351
Atrial tachycardia 32.88 10.90 5 551374 7128 79185881
Disease susceptibility 32.87 10.90 23 551356 300 79192709
Spinal fusion surgery 32.83 10.90 95 551284 5143 79187866
Infusion site swelling 32.80 10.90 7 551372 7819 79185190
Rash pustular 32.74 10.90 160 551219 11151 79181858
Brain herniation 32.69 10.90 6 551373 7457 79185552
Blood potassium decreased 32.69 10.90 188 551191 46324 79146685
Perirectal abscess 32.58 10.90 54 551325 1987 79191022
Bone marrow oedema 32.47 10.90 49 551330 1662 79191347
Micturition urgency 32.39 10.90 24 551355 12617 79180392
Drug level above therapeutic 32.35 10.90 10 551369 8713 79184296
Ileus paralytic 32.30 10.90 13 551366 9607 79183402
Tenosynovitis stenosans 32.28 10.90 68 551311 3010 79189999
Ventricular extrasystoles 32.27 10.90 54 551325 19650 79173359
Wrong product administered 32.24 10.90 11 551368 9001 79184008
Hyperreflexia 32.21 10.90 9 551370 8376 79184633
Faeces discoloured 32.10 10.90 99 551280 29028 79163981
Colostomy 32.05 10.90 39 551340 1072 79191937
Hypercholesterolaemia 32.03 10.90 271 551108 22824 79170185
Rheumatoid factor negative 31.94 10.90 40 551339 1133 79191876
Non-cardiac chest pain 31.76 10.90 13 551366 9511 79183498
Cutaneous vasculitis 31.68 10.90 127 551252 8125 79184884
Ventricular hypertrophy 31.67 10.90 5 551374 6933 79186076
Apnoea 31.60 10.90 21 551358 11683 79181326
Eye disorder 31.57 10.90 273 551106 23139 79169870
Apathy 31.53 10.90 26 551353 12951 79180058
Metastases to lung 31.43 10.90 48 551331 18115 79174894
Tropical infectious disease 31.39 10.90 12 551367 36 79192973
Cyst 31.35 10.90 183 551196 13657 79179352
Large intestine anastomosis 31.29 10.90 15 551364 89 79192920
Malignant melanoma stage I 31.27 10.90 17 551362 136 79192873
Vascular access complication 31.23 10.90 55 551324 2127 79190882
Concomitant disease aggravated 31.23 10.90 27 551352 13140 79179869
Dysplasia 31.14 10.90 43 551336 1343 79191666
Hepatic necrosis 31.04 10.90 12 551367 9088 79183921
Hypotonia 31.00 10.90 26 551353 12844 79180165
Autoimmune disorder 30.98 10.90 209 551170 16403 79176606
Pseudomonas infection 30.92 10.90 61 551318 20842 79172167
Product complaint 30.90 10.90 28 551351 13321 79179688
Short-bowel syndrome 30.88 10.90 28 551351 541 79192468
Laryngeal disorder 30.85 10.90 38 551341 1058 79191951
Accident 30.83 10.90 132 551247 8699 79184310
Bursitis infective staphylococcal 30.82 10.90 14 551365 72 79192937
Myocarditis 30.80 10.90 65 551314 21668 79171341
Drug abuser 30.69 10.90 3 551376 6010 79186999
Metastases to liver 30.66 10.90 97 551282 28217 79164792
Pulmonary congestion 30.66 10.90 91 551288 27009 79166000
Intestinal mass 30.63 10.90 41 551338 1242 79191767
Nervousness 30.51 10.90 123 551256 33292 79159717
Sleep apnoea syndrome 30.41 10.90 139 551240 36339 79156670
Ectopic pregnancy 30.39 10.90 48 551331 1695 79191314
Therapeutic response changed 30.19 10.90 41 551338 1260 79191749
Incontinence 30.14 10.90 32 551347 14132 79178877
Erythrodermic psoriasis 30.08 10.90 48 551331 1710 79191299
SARS-CoV-2 test positive 29.91 10.90 160 551219 11556 79181453
Injection site inflammation 29.80 10.90 77 551302 3899 79189110
Neuralgia 29.79 10.90 124 551255 33260 79159749
Pulmonary function test decreased 29.71 10.90 8 551371 7629 79185380
Blood thyroid stimulating hormone increased 29.65 10.90 15 551364 9693 79183316
Postoperative wound complication 29.65 10.90 44 551335 1470 79191539
Colostomy closure 29.58 10.90 18 551361 182 79192827
Thyroiditis subacute 29.55 10.90 22 551357 318 79192691
Oedema 29.55 10.90 616 550763 118964 79074045
SAPHO syndrome 29.54 10.90 24 551355 397 79192612
Cardiomyopathy 29.49 10.90 101 551278 28673 79164336
Enterococcal infection 29.46 10.90 39 551340 15621 79177388
Amnesia 29.43 10.90 286 551093 62771 79130238
Proctocolectomy 29.41 10.90 17 551362 155 79192854
Tubulointerstitial nephritis 29.37 10.90 150 551229 38085 79154924
Post procedural sepsis 29.23 10.90 27 551352 535 79192474
Infiltration anaesthesia 29.23 10.90 17 551362 157 79192852
Wrist surgery 29.15 10.90 32 551347 785 79192224
Amylase increased 29.08 10.90 21 551358 11188 79181821
Personality disorder 29.04 10.90 4 551375 6142 79186867
Purulence 28.98 10.90 53 551326 2112 79190897
Embolic stroke 28.97 10.90 9 551370 7817 79185192
General symptom 28.95 10.90 58 551321 2476 79190533
Clonus 28.91 10.90 6 551373 6834 79186175
Protein urine present 28.88 10.90 17 551362 10095 79182914
Device malfunction 28.87 10.90 250 551129 21198 79171811
Neck surgery 28.87 10.90 48 551331 1771 79191238
Post procedural fistula 28.83 10.90 21 551358 293 79192716
Gout 28.81 10.90 82 551297 24667 79168342
Psoriasis area severity index increased 28.67 10.90 15 551364 110 79192899
Pseudopolyposis 28.67 10.90 14 551365 87 79192922
Autoimmune haemolytic anaemia 28.67 10.90 11 551368 8369 79184640
Skin wound 28.64 10.90 41 551338 1325 79191684
Anal hypoaesthesia 28.63 10.90 8 551371 4 79193005
Stress 28.57 10.90 737 550642 78875 79114134
Skin mass 28.52 10.90 121 551258 7942 79185067
Hiccups 28.46 10.90 17 551362 10014 79182995
Failure to thrive 28.44 10.90 24 551355 11820 79181189
Euphoric mood 28.39 10.90 9 551370 7717 79185292
Tonsillectomy 28.34 10.90 28 551351 605 79192404
Ventricular dysfunction 28.28 10.90 4 551375 6019 79186990
Synovial fluid analysis 28.17 10.90 55 551324 2304 79190705
Tinnitus 28.13 10.90 185 551194 44148 79148861
Ocular sarcoidosis 28.07 10.90 11 551368 36 79192973
Breast cancer stage I 28.06 10.90 6 551373 6694 79186315
Lipase increased 28.03 10.90 44 551335 16422 79176587
Large intestinal obstruction 28.00 10.90 67 551312 3232 79189777
Bone density abnormal 28.00 10.90 64 551315 2996 79190013
Depressed mood 27.96 10.90 208 551171 48272 79144737
Nail psoriasis 27.90 10.90 28 551351 617 79192392
Cerebral haematoma 27.88 10.90 10 551369 7932 79185077
Cholecystitis chronic 27.81 10.90 17 551362 9889 79183120
Muscle haemorrhage 27.74 10.90 5 551374 6295 79186714
Allergy to vaccine 27.70 10.90 18 551361 206 79192803
Intra-abdominal fluid collection 27.55 10.90 65 551314 3107 79189902
Peritonitis bacterial 27.44 10.90 16 551363 9551 79183458
Injury associated with device 27.42 10.90 69 551310 3437 79189572
Ventricular hypokinesia 27.36 10.90 15 551364 9264 79183745
Device occlusion 27.34 10.90 25 551354 11841 79181168
Glomerular filtration rate decreased 27.33 10.90 74 551305 22628 79170381
Refusal of treatment by patient 27.30 10.90 14 551365 8977 79184032
Rhinorrhoea 27.29 10.90 366 551013 75708 79117301
Partial seizures 27.23 10.90 14 551365 8964 79184045
Peripheral venous disease 27.22 10.90 196 551183 15713 79177296
Bladder transitional cell carcinoma 27.16 10.90 58 551321 2592 79190417
T-cell lymphoma 27.16 10.90 39 551340 1264 79191745
Dermal cyst 27.09 10.90 59 551320 2673 79190336
Enterovesical fistula 27.05 10.90 37 551342 1145 79191864
Psychomotor retardation 27.03 10.90 5 551374 6179 79186830
Electroencephalogram abnormal 26.99 10.90 3 551376 5431 79187578
Visceral leishmaniasis 26.99 10.90 36 551343 1087 79191922
Blood pressure inadequately controlled 26.99 10.90 5 551374 6172 79186837
Pulmonary sarcoidosis 26.94 10.90 40 551339 1337 79191672
Jaundice cholestatic 26.93 10.90 23 551356 11261 79181748
Restless legs syndrome 26.91 10.90 62 551317 20030 79172979
Hypertriglyceridaemia 26.87 10.90 29 551350 12711 79180298
Rash morbilliform 26.82 10.90 5 551374 6145 79186864
Heavy exposure to ultraviolet light 26.79 10.90 11 551368 42 79192967
Hypersensitivity vasculitis 26.77 10.90 107 551272 6836 79186173
Myelodysplastic syndrome 26.76 10.90 113 551266 30188 79162821
Drug level decreased 26.74 10.90 181 551198 14221 79178788
Glioblastoma 26.61 10.90 44 551335 1616 79191393
Squamous cell carcinoma 26.46 10.90 192 551187 15430 79177579
Spinal osteoarthritis 26.39 10.90 204 551175 16723 79176286
Drug screen positive 26.29 10.90 5 551374 6058 79186951
Hernia 26.27 10.90 205 551174 16854 79176155
Night sweats 26.20 10.90 506 550873 51589 79141420
Fracture delayed union 26.18 10.90 50 551329 2060 79190949
Extrapulmonary tuberculosis 26.15 10.90 22 551357 383 79192626
Hyperphosphataemia 26.12 10.90 6 551373 6370 79186639
Thrombotic thrombocytopenic purpura 26.12 10.90 6 551373 6370 79186639
Drug level abnormal 26.07 10.90 21 551358 343 79192666
Anal fissure 26.02 10.90 114 551265 7589 79185420
Complication of device insertion 25.97 10.90 6 551373 6344 79186665
Scar 25.88 10.90 187 551192 15009 79178000
Bone disorder 25.84 10.90 223 551156 18890 79174119
Alopecia areata 25.79 10.90 46 551333 1797 79191212
Hip fracture 25.77 10.90 117 551262 30644 79162365
Catheter site erythema 25.76 10.90 3 551376 5237 79187772
Decubitus ulcer 25.68 10.90 43 551336 15644 79177365
Brain injury 25.67 10.90 25 551354 11492 79181517
Postoperative abscess 25.67 10.90 29 551350 735 79192274
Neuroendocrine carcinoma of the skin 25.51 10.90 38 551341 1274 79191735
Small intestine operation 25.47 10.90 11 551368 49 79192960
Tricuspid valve incompetence 25.46 10.90 62 551317 19650 79173359
Infected fistula 25.45 10.90 22 551357 398 79192611
Atrial septal defect acquired 25.44 10.90 9 551370 20 79192989
Jejunal stenosis 25.35 10.90 13 551366 91 79192918
Prolonged labour 25.34 10.90 23 551356 445 79192564
Central nervous system inflammation 25.33 10.90 20 551359 317 79192692
Groin pain 25.26 10.90 166 551213 12914 79180095
Skin reaction 25.25 10.90 194 551185 15874 79177135
Prosthesis user 25.20 10.90 12 551367 70 79192939
Immune system disorder 25.09 10.90 146 551233 10883 79182126
Small intestine adenocarcinoma 25.08 10.90 16 551363 177 79192832
Catheter site haemorrhage 24.98 10.90 3 551376 5114 79187895
Anal skin tags 24.97 10.90 23 551356 454 79192555
Bladder transitional cell carcinoma stage II 24.92 10.90 12 551367 72 79192937
Pseudomonal sepsis 24.92 10.90 6 551373 6168 79186841
Juvenile idiopathic arthritis 24.83 10.90 81 551298 4682 79188327
Gynaecomastia 24.79 10.90 11 551368 7670 79185339
Epilepsy 24.68 10.90 173 551206 40687 79152322
Thrombosis in device 24.66 10.90 4 551375 5438 79187571
Weight decreased 24.65 10.90 2117 549262 353081 78839928
Diffuse alopecia 24.63 10.90 32 551347 941 79192068
Nephrolithiasis 24.59 10.90 511 550868 52780 79140229
Hunger 24.58 10.90 4 551375 5424 79187585
Performance status decreased 24.56 10.90 6 551373 6107 79186902
Glycosylated haemoglobin increased 24.55 10.90 61 551318 19199 79173810
Ammonia increased 24.54 10.90 11 551368 7624 79185385
Myocardial infarction 24.48 10.90 1032 550347 183097 79009912
Drug resistance 24.40 10.90 181 551198 42032 79150977
Rebound psoriasis 24.34 10.90 16 551363 187 79192822
Legionella infection 24.29 10.90 29 551350 781 79192228
Blood triglycerides increased 24.28 10.90 70 551309 20970 79172039
Exposure to communicable disease 24.24 10.90 24 551355 520 79192489
Colonoscopy abnormal 24.20 10.90 16 551363 189 79192820
Eye inflammation 24.06 10.90 98 551281 6315 79186694
Aplasia 24.01 10.90 12 551367 7808 79185201
Gastrointestinal tract adenoma 24.01 10.90 23 551356 478 79192531
Brain death 23.95 10.90 5 551374 5672 79187337
Anorectal swelling 23.88 10.90 12 551367 80 79192929
Ankle arthroplasty 23.88 10.90 40 551339 1485 79191524
Local reaction 23.81 10.90 25 551354 582 79192427
Proctalgia 23.80 10.90 134 551245 9867 79183142
Testicular seminoma (pure) 23.80 10.90 10 551369 41 79192968
Vasculitic rash 23.78 10.90 49 551330 2135 79190874
Autoantibody positive 23.60 10.90 13 551366 107 79192902
Parapsoriasis 23.59 10.90 17 551362 233 79192776
Brachiocephalic artery stenosis 23.54 10.90 9 551370 27 79192982
Intervertebral disc annular tear 23.54 10.90 9 551370 27 79192982
Duodenal ulcer haemorrhage 23.53 10.90 10 551369 7153 79185856
Colonic abscess 23.47 10.90 38 551341 1371 79191638
Left ventricular dysfunction 23.39 10.90 63 551316 19298 79173711
Herpes simplex oesophagitis 23.36 10.90 20 551359 357 79192652
Stoma site abscess 23.35 10.90 17 551362 237 79192772
Stress at work 23.33 10.90 34 551345 1117 79191892
Liver injury 23.30 10.90 534 550845 56080 79136929
Road traffic accident 23.30 10.90 428 550951 43236 79149773
Tongue oedema 23.28 10.90 10 551369 7107 79185902
Blood immunoglobulin E increased 23.19 10.90 6 551373 5876 79187133
Tonsillar hypertrophy 23.17 10.90 40 551339 1522 79191487
Duodenal ulcer 23.16 10.90 49 551330 16320 79176689
Anastomotic ulcer 23.12 10.90 27 551352 710 79192299
Catheter site infection 23.11 10.90 9 551370 6786 79186223
Kidney infection 23.10 10.90 242 551137 21609 79171400
Stoma obstruction 23.05 10.90 17 551362 242 79192767
Genital abscess 23.04 10.90 16 551363 206 79192803
Hypersomnia 23.01 10.90 82 551297 23004 79170005
Immune thrombocytopenia 23.00 10.90 56 551323 17749 79175260
Peripheral sensory neuropathy 22.98 10.90 34 551345 12999 79180010
Cytomegalovirus chorioretinitis 22.83 10.90 5 551374 5485 79187524
Vertebral osteophyte 22.72 10.90 19 551360 328 79192681
Coccidioidomycosis 22.69 10.90 36 551343 1276 79191733
Joint instability 22.69 10.90 39 551340 1479 79191530
Product preparation error 22.67 10.90 6 551373 5787 79187222
Clostridium difficile infection 22.63 10.90 418 550961 42267 79150742
Prostatic specific antigen increased 22.63 10.90 23 551356 10363 79182646
Hyperuricaemia 22.59 10.90 29 551350 11770 79181239
Chronic inflammatory demyelinating polyradiculoneuropathy 22.58 10.90 34 551345 1151 79191858
Pneumatosis intestinalis 22.55 10.90 8 551371 6389 79186620
Cutaneous lymphoma 22.53 10.90 17 551362 251 79192758
Hip surgery 22.33 10.90 61 551318 3194 79189815
Tendon rupture 22.28 10.90 152 551227 11974 79181035
Somnambulism 22.24 10.90 6 551373 5715 79187294
Gastric haemorrhage 22.19 10.90 44 551335 15006 79178003
Anger 22.15 10.90 54 551325 17108 79175901
Intestinal ischaemia 22.08 10.90 36 551343 13234 79179775
Obliterative bronchiolitis 22.04 10.90 58 551321 2970 79190039
Paracoccidioides infection 21.94 10.90 11 551368 73 79192936
Dermatitis acneiform 21.92 10.90 22 551357 9971 79183038
Myelitis 21.87 10.90 50 551329 2341 79190668
Arthritis reactive 21.82 10.90 24 551355 590 79192419
Escherichia bacteraemia 21.81 10.90 9 551370 6553 79186456
Disturbance in social behaviour 21.76 10.90 4 551375 4966 79188043
Device use error 21.65 10.90 11 551368 7090 79185919
Obsessive-compulsive disorder 21.61 10.90 7 551372 5920 79187089
Pyoderma 21.59 10.90 21 551358 445 79192564
Stomal hernia 21.52 10.90 19 551360 354 79192655
Proctectomy 21.48 10.90 15 551364 195 79192814
Peritoneal cyst 21.47 10.90 6 551373 3 79193006
Pulmonary toxicity 21.46 10.90 158 551221 12756 79180253
Pulmonary arterial pressure increased 21.44 10.90 3 551376 4552 79188457
Respiratory syncytial virus infection 21.44 10.90 20 551359 9382 79183627
Seminoma 21.41 10.90 15 551364 196 79192813
Scarlet fever 21.40 10.90 13 551366 131 79192878
Congestive hepatopathy 21.39 10.90 3 551376 4544 79188465
Mean cell volume decreased 21.34 10.90 79 551300 4868 79188141
Rectal cancer 21.34 10.90 63 551316 3450 79189559
Psychomotor skills impaired 21.31 10.90 5 551374 5232 79187777
Haemorrhagic stroke 21.30 10.90 27 551352 11019 79181990
Adenocarcinoma of the cervix 21.22 10.90 15 551364 199 79192810
Affect lability 21.22 10.90 28 551351 11231 79181778
Anorectal stenosis 21.22 10.90 9 551370 38 79192971
Lung cancer metastatic 21.21 10.90 65 551314 3634 79189375
Quality of life decreased 21.20 10.90 134 551245 10286 79182723
Enterostomy 21.16 10.90 16 551363 237 79192772
Hypertransaminasaemia 21.13 10.90 31 551348 11893 79181116
Post procedural swelling 21.12 10.90 23 551356 559 79192450
Neutrophil count increased 21.10 10.90 118 551261 29278 79163731
Eyelid oedema 21.07 10.90 39 551340 13648 79179361
Malignant melanoma in situ 21.03 10.90 50 551329 2402 79190607
Functional gastrointestinal disorder 20.95 10.90 79 551300 4911 79188098
Gastric ulcer haemorrhage 20.82 10.90 19 551360 9008 79184001
Testis cancer 20.80 10.90 33 551346 1170 79191839
Prescribed overdose 20.80 10.90 373 551006 37510 79155499
Self-medication 20.69 10.90 5 551374 5127 79187882
Parakeratosis 20.63 10.90 19 551360 375 79192634
Impaired quality of life 20.59 10.90 170 551209 14216 79178793
Conjunctival hyperaemia 20.56 10.90 3 551376 4410 79188599
Hypertensive crisis 20.55 10.90 74 551305 20696 79172313
Nerve block 20.52 10.90 25 551354 688 79192321
Rhinovirus infection 20.51 10.90 15 551364 7938 79185071
Pneumocystis jirovecii pneumonia 20.45 10.90 136 551243 32372 79160637
Adenovirus infection 20.43 10.90 17 551362 8430 79184579
Renal colic 20.42 10.90 54 551325 2773 79190236
Inguinal hernia 20.40 10.90 94 551285 6394 79186615
Rectal ulcer 20.36 10.90 45 551334 2059 79190950
Metabolic disorder 20.33 10.90 20 551359 9150 79183859
Acute graft versus host disease in skin 20.33 10.90 14 551365 7644 79185365
Cutaneous lupus erythematosus 20.33 10.90 56 551323 2947 79190062
Pregnancy 20.31 10.90 279 551100 26572 79166437
Hemiparesis 20.29 10.90 143 551236 33590 79159419
Musculoskeletal chest pain 20.27 10.90 95 551284 24669 79168340
Visual acuity reduced 20.23 10.90 120 551259 29349 79163660
Osteosclerosis 20.23 10.90 67 551312 3904 79189105
Mean cell haemoglobin decreased 20.18 10.90 91 551288 6133 79186876
Product prescribing error 20.18 10.90 205 551174 44608 79148401
Polyneuropathy 20.15 10.90 92 551287 24059 79168950
Histone antibody positive 20.13 10.90 11 551368 89 79192920
Autoimmune pancreatitis 20.11 10.90 24 551355 646 79192363
Disseminated large cell lymphoma 20.11 10.90 10 551369 65 79192944
Chronic disease 20.06 10.90 13 551366 148 79192861
Treatment noncompliance 20.03 10.90 248 551131 52020 79140989
Torus fracture 20.03 10.90 11 551368 90 79192919
Haemorrhoidal haemorrhage 20.01 10.90 11 551368 6784 79186225
Cerebral ischaemia 19.94 10.90 29 551350 11166 79181843
Terminal ileitis 19.93 10.90 28 551351 889 79192120
Infection transmission via personal contact 19.91 10.90 5 551374 0 79193009
Atrioventricular block second degree 19.90 10.90 13 551366 7299 79185710
Klebsiella infection 19.87 10.90 50 551329 15670 79177339
Body height decreased 19.86 10.90 18 551361 8562 79184447
Accidental death 19.80 10.90 3 551376 4288 79188721
Blood iron decreased 19.79 10.90 178 551201 15256 79177753
Mitral valve incompetence 19.78 10.90 116 551263 28449 79164560
Hyperlactacidaemia 19.72 10.90 7 551372 5588 79187421
Compression fracture 19.70 10.90 10 551369 6450 79186559
Autonomic nervous system imbalance 19.70 10.90 4 551375 4626 79188383
Tuberculosis gastrointestinal 19.65 10.90 22 551357 552 79192457
Colectomy total 19.64 10.90 18 551361 353 79192656
Benign lung neoplasm 19.63 10.90 11 551368 94 79192915
Viral upper respiratory tract infection 19.58 10.90 118 551261 8908 79184101
Spinal meningioma benign 19.53 10.90 11 551368 95 79192914
Cholecystitis 19.51 10.90 83 551296 22129 79170880
Aortic elongation 19.50 10.90 12 551367 124 79192885
Goitre 19.50 10.90 83 551296 5456 79187553
Hypokinesia 19.47 10.90 67 551312 18993 79174016
Hydronephrosis 19.46 10.90 59 551320 17395 79175614
Respiratory rate decreased 19.46 10.90 6 551373 5237 79187772
Polychondritis 19.46 10.90 22 551357 558 79192451
Hypoventilation 19.45 10.90 13 551366 7211 79185798
Diabetes insipidus 19.43 10.90 6 551373 5231 79187778
Stoma complication 19.29 10.90 26 551353 793 79192216
Subcorneal pustular dermatosis 19.27 10.90 10 551369 72 79192937
Anorectal ulcer 19.25 10.90 9 551370 50 79192959
Acquired hydrocele 19.25 10.90 9 551370 50 79192959
Non-consummation 19.25 10.90 9 551370 50 79192959
Selective abortion 19.25 10.90 9 551370 50 79192959
Acne cystic 19.21 10.90 22 551357 566 79192443
Metatarsalgia 19.14 10.90 15 551364 235 79192774
Vaginal fistula 19.14 10.90 16 551363 276 79192733
Product physical issue 19.14 10.90 3 551376 4182 79188827
Lower respiratory tract infection viral 19.10 10.90 32 551347 1188 79191821
Granulomatous lymphadenitis 19.09 10.90 16 551363 277 79192732
Precancerous skin lesion 19.09 10.90 34 551345 1327 79191682
International normalised ratio abnormal 19.03 10.90 8 551371 5760 79187249
Extremity contracture 19.02 10.90 39 551340 1693 79191316
Dry skin 19.01 10.90 343 551036 67652 79125357
Lymphadenitis 18.97 10.90 73 551306 4582 79188427
Priapism 18.94 10.90 4 551375 4501 79188508
Antiphospholipid syndrome 18.93 10.90 41 551338 1850 79191159
Injection site oedema 18.91 10.90 34 551345 1337 79191672
Pericardial haemorrhage 18.88 10.90 4 551375 4491 79188518
Wound infection 18.85 10.90 251 551128 23740 79169269
Overwork 18.83 10.90 9 551370 53 79192956
Pruritus genital 18.83 10.90 4 551375 4482 79188527
Iris adhesions 18.81 10.90 21 551358 525 79192484
Lymphadenopathy mediastinal 18.79 10.90 70 551309 4326 79188683
Anal ulcer 18.78 10.90 34 551345 1344 79191665
Feeling hot 18.76 10.90 295 551084 59439 79133570
Urinary tract infection 18.75 10.90 1638 549741 272874 78920135
Treatment delayed 18.71 10.90 10 551369 77 79192932
Pleuropericarditis 18.70 10.90 19 551360 425 79192584
Bile acid malabsorption 18.65 10.90 14 551365 205 79192804
Pelvic abscess 18.63 10.90 44 551335 2105 79190904
Urine leukocyte esterase positive 18.56 10.90 3 551376 4088 79188921
Parainfluenzae virus infection 18.56 10.90 8 551371 5674 79187335
Skin hyperpigmentation 18.54 10.90 14 551365 7289 79185720
Soft tissue disorder 18.53 10.90 60 551319 3455 79189554
Myositis 18.50 10.90 69 551310 19099 79173910
Wound complication 18.50 10.90 76 551303 4917 79188092
Human herpesvirus 6 infection 18.45 10.90 7 551372 5363 79187646
Stricturoplasty 18.45 10.90 6 551373 9 79193000
Myxoid liposarcoma 18.45 10.90 6 551373 9 79193000
Liver transplant 18.45 10.90 4 551375 4419 79188590
Head discomfort 18.43 10.90 46 551333 14456 79178553
Tenderness 18.43 10.90 247 551132 23395 79169614
Post procedural discharge 18.42 10.90 24 551355 708 79192301
Butterfly rash 18.41 10.90 38 551341 1658 79191351
Tension 18.33 10.90 4 551375 4400 79188609
Type I hypersensitivity 18.30 10.90 4 551375 4394 79188615
Diastolic dysfunction 18.29 10.90 29 551350 10782 79182227
Blood phosphorus increased 18.23 10.90 27 551352 10320 79182689
Intercepted product prescribing error 18.22 10.90 16 551363 296 79192713
Arteriospasm coronary 18.20 10.90 12 551367 6704 79186305
Venous injury 18.19 10.90 25 551354 777 79192232
Sleep disorder 18.18 10.90 745 550634 84932 79108077
Animal bite 18.17 10.90 50 551329 2629 79190380
Pneumonia viral 18.16 10.90 117 551262 9041 79183968
Hypogammaglobulinaemia 18.13 10.90 39 551340 12912 79180097
Thinking abnormal 18.12 10.90 40 551339 13121 79179888
Drain placement 18.06 10.90 12 551367 143 79192866
Renal disorder 17.99 10.90 195 551184 41910 79151099
Blood phosphorus decreased 17.95 10.90 12 551367 6656 79186353
Mesangioproliferative glomerulonephritis 17.85 10.90 11 551368 114 79192895
Atelectasis 17.85 10.90 140 551239 32117 79160892
Mycobacterium marinum infection 17.84 10.90 19 551360 450 79192559
Multifocal motor neuropathy 17.79 10.90 8 551371 40 79192969
Gastroenterostomy 17.79 10.90 9 551370 61 79192948
Staphylococcal bacteraemia 17.77 10.90 36 551343 12182 79180827
Gait disturbance 17.76 10.90 1666 549713 205840 78987169
Serum ferritin decreased 17.74 10.90 46 551333 2334 79190675
Anaplastic large-cell lymphoma 17.72 10.90 14 551365 222 79192787
Injection site nodule 17.69 10.90 62 551317 3718 79189291
Exercise tolerance decreased 17.67 10.90 22 551357 9049 79183960
Acne conglobata 17.62 10.90 7 551372 24 79192985
Gastrointestinal dilation procedure 17.58 10.90 5 551374 3 79193006
Bacterial abdominal infection 17.58 10.90 5 551374 3 79193006
Capillary leak syndrome 17.53 10.90 3 551376 3922 79189087
Fungaemia 17.50 10.90 5 551374 4586 79188423
Blood calcium increased 17.50 10.90 28 551351 10372 79182637
Lower limb fracture 17.47 10.90 241 551138 22974 79170035
Transaminases increased 17.46 10.90 252 551127 51491 79141518
Injection site discolouration 17.45 10.90 101 551278 7513 79185496
Blood bicarbonate decreased 17.45 10.90 7 551372 5184 79187825
Diabetic eye disease 17.38 10.90 12 551367 153 79192856
Taste disorder 17.28 10.90 54 551325 15769 79177240
Short stature 17.25 10.90 23 551356 694 79192315
Hypermobility syndrome 17.24 10.90 20 551359 522 79192487
Intra-abdominal haemorrhage 17.21 10.90 5 551374 4535 79188474
Pneumonia fungal 17.20 10.90 32 551347 11178 79181831
Gangrene 17.20 10.90 22 551357 8942 79184067
Acquired claw toe 17.13 10.90 10 551369 93 79192916
Alcohol use 17.10 10.90 6 551373 4825 79188184
Periumbilical abscess 17.09 10.90 9 551370 67 79192942
Gastrointestinal anastomotic stenosis 17.06 10.90 6 551373 13 79192996
Parinaud syndrome 17.06 10.90 6 551373 13 79192996
C-reactive protein 17.06 10.90 74 551305 4905 79188104
Colon neoplasm 17.03 10.90 25 551354 827 79192182
Acute psychosis 16.99 10.90 4 551375 4176 79188833
Subdural haemorrhage 16.99 10.90 10 551369 5938 79187071
Poor quality sleep 16.97 10.90 90 551289 22632 79170377
Injection site paraesthesia 16.96 10.90 21 551358 588 79192421
Cardiac failure chronic 16.90 10.90 32 551347 11103 79181906
Steatohepatitis 16.90 10.90 27 551352 963 79192046
Neutrophilia 16.88 10.90 18 551361 7933 79185076
Urinary tract infection bacterial 16.88 10.90 12 551367 6444 79186565
Sinus node dysfunction 16.84 10.90 17 551362 7684 79185325
Incoherent 16.80 10.90 17 551362 7675 79185334
Phototherapy 16.80 10.90 7 551372 28 79192981
Gastrointestinal dysplasia 16.80 10.90 7 551372 28 79192981
Retching 16.78 10.90 63 551316 17404 79175605
Accident at work 16.75 10.90 29 551350 1106 79191903
Spinal disorder 16.75 10.90 125 551254 10135 79182874
Upper limb fracture 16.71 10.90 194 551185 17773 79175236
Eye symptom 16.69 10.90 10 551369 98 79192911
Haemolytic uraemic syndrome 16.68 10.90 5 551374 4444 79188565
Infusion site pruritus 16.62 10.90 4 551375 4114 79188895
Perineal fistula 16.61 10.90 8 551371 48 79192961
Pancreatic steatosis 16.57 10.90 29 551350 1116 79191893
Eczema infected 16.55 10.90 9 551370 72 79192937
Conjunctival haemorrhage 16.55 10.90 10 551369 5855 79187154
Osteopenia 16.51 10.90 197 551182 18167 79174842
Thyroidectomy 16.50 10.90 26 551353 916 79192093
Mesenteritis 16.49 10.90 16 551363 338 79192671
Adenocarcinoma of colon 16.48 10.90 79 551300 5462 79187547
Choking 16.48 10.90 37 551342 12064 79180945
Melkersson-Rosenthal syndrome 16.47 10.90 6 551373 15 79192994
Bladder neck operation 16.47 10.90 5 551374 5 79193004
Cardiolipin antibody 16.47 10.90 5 551374 5 79193004
Magnetic resonance imaging thoracic abnormal 16.47 10.90 6 551373 15 79192994
Colitis ischaemic 16.36 10.90 53 551326 15306 79177703
Sebaceous gland infection 16.32 10.90 12 551367 170 79192839
Eye infection staphylococcal 16.32 10.90 12 551367 170 79192839
Osteolysis 16.30 10.90 68 551311 4430 79188579
Hepatomegaly 16.29 10.90 71 551308 18803 79174206
Graft versus host disease in skin 16.26 10.90 11 551368 6062 79186947
Gallbladder operation 16.25 10.90 40 551339 1965 79191044
Cross sensitivity reaction 16.23 10.90 3 551376 3709 79189300
Pneumonia cytomegaloviral 16.22 10.90 7 551372 4962 79188047
Proteinuria 16.20 10.90 145 551234 32357 79160652
Intestinal fistula infection 16.20 10.90 6 551373 16 79192993
Acute graft versus host disease in intestine 16.17 10.90 4 551375 4037 79188972
Gastric ulcer 16.15 10.90 153 551226 33752 79159257
Respiration abnormal 16.13 10.90 18 551361 7770 79185239
Stoma site ulcer 16.12 10.90 14 551365 255 79192754
Mass excision 16.07 10.90 16 551363 349 79192660
Eye movement disorder 16.06 10.90 19 551360 7992 79185017
Dissociation 16.05 10.90 4 551375 4017 79188992
Gastroenteritis viral 16.02 10.90 251 551128 24580 79168429
Intestinal mucosal atrophy 16.01 10.90 5 551374 6 79193003
Inner ear inflammation 16.01 10.90 5 551374 6 79193003
Lipodystrophy acquired 15.96 10.90 5 551374 4320 79188689
Lymphoproliferative disorder 15.95 10.90 79 551300 5536 79187473
Muscular sarcoidosis 15.92 10.90 4 551375 0 79193009
Ocular fistula 15.92 10.90 4 551375 0 79193009
Oesophageal squamous cell carcinoma stage III 15.92 10.90 4 551375 0 79193009
Lip and/or oral cavity cancer stage 0 15.92 10.90 4 551375 0 79193009
Hepatitis fulminant 15.91 10.90 16 551363 7246 79185763
Craniocerebral injury 15.91 10.90 8 551371 5188 79187821
Macular degeneration 15.90 10.90 133 551246 11163 79181846
Atrial thrombosis 15.89 10.90 3 551376 3653 79189356
Seasonal allergy 15.87 10.90 59 551320 16347 79176662
Genital haemorrhage 15.87 10.90 12 551367 6243 79186766
Bone swelling 15.85 10.90 36 551343 1678 79191331
Muscle spasms 15.85 10.90 1018 550361 173712 79019297
Pain in jaw 15.85 10.90 224 551155 45927 79147082
Bowel movement irregularity 15.83 10.90 86 551293 6248 79186761
Lower respiratory tract inflammation 15.82 10.90 11 551368 142 79192867
Feeling abnormal 15.76 10.90 920 550459 158279 79034730
Dyschezia 15.75 10.90 51 551328 2937 79190072
Blood uric acid increased 15.74 10.90 44 551335 13316 79179693
Monoclonal gammopathy 15.74 10.90 25 551354 887 79192122
Adverse food reaction 15.73 10.90 7 551372 34 79192975
Oral surgery 15.71 10.90 28 551351 1093 79191916
Salivary gland adenoma 15.69 10.90 6 551373 18 79192991
Demyelinating polyneuropathy 15.68 10.90 36 551343 1690 79191319
Tension headache 15.67 10.90 16 551363 7195 79185814
Anosmia 15.66 10.90 23 551356 8821 79184188
Renal tubular acidosis 15.63 10.90 3 551376 3611 79189398
Carpal tunnel syndrome 15.63 10.90 205 551174 19323 79173686
Miliary pneumonia 15.58 10.90 5 551374 7 79193002
Axillary mass 15.58 10.90 22 551357 702 79192307
Hepatic steatosis 15.54 10.90 356 551023 37382 79155627
Bladder neoplasm 15.53 10.90 36 551343 1701 79191308
Hepatorenal syndrome 15.53 10.90 5 551374 4244 79188765
Lumbar spinal stenosis 15.49 10.90 75 551304 5207 79187802
Blood glucose abnormal 15.48 10.90 31 551348 10535 79182474
Enthesophyte 15.48 10.90 8 551371 57 79192952
Rheumatoid factor increased 15.48 10.90 37 551342 1784 79191225
Oesophageal varices haemorrhage 15.45 10.90 5 551374 4231 79188778
Shoulder operation 15.44 10.90 48 551331 2704 79190305
Nystagmus 15.44 10.90 28 551351 9876 79183133
Benign prostatic hyperplasia 15.42 10.90 36 551343 11576 79181433
Lip ulceration 15.38 10.90 43 551336 2282 79190727
Diffuse vasculitis 15.35 10.90 10 551369 115 79192894
Nephrogenic anaemia 15.35 10.90 4 551375 3898 79189111
Staphylococcal infection 15.28 10.90 519 550860 57776 79135233
International normalised ratio decreased 15.28 10.90 20 551359 8050 79184959
Pharyngeal oedema 15.26 10.90 176 551203 16096 79176913
Orthopnoea 15.24 10.90 29 551350 10044 79182965
Product substitution 15.21 10.90 9 551370 86 79192923
Portal hypertension 15.19 10.90 16 551363 7092 79185917
Nail operation 15.18 10.90 21 551358 657 79192352
Pneumothorax 15.17 10.90 124 551255 28199 79164810
Dermatitis atopic 15.17 10.90 29 551350 10027 79182982
Nasal polyps 15.10 10.90 17 551362 7310 79185699
Pain of skin 15.05 10.90 161 551218 14452 79178557
Lipoma 15.04 10.90 51 551328 3008 79190001
Muscle fatigue 15.01 10.90 56 551323 3463 79189546
White matter lesion 14.99 10.90 39 551340 1983 79191026
Tumour haemorrhage 14.92 10.90 5 551374 4139 79188870
Urine abnormality 14.92 10.90 21 551358 8198 79184811
Lip oedema 14.92 10.90 13 551366 6303 79186706
Dry mouth 14.91 10.90 479 550900 87540 79105469
Renal cell carcinoma 14.91 10.90 87 551292 6491 79186518
Wrong technique in product usage process 14.91 10.90 639 550740 73236 79119773
Superficial spreading melanoma stage unspecified 14.89 10.90 14 551365 284 79192725
Ileal perforation 14.88 10.90 26 551353 999 79192010
Pancreatic duct stenosis 14.87 10.90 13 551366 239 79192770
Larynx irritation 14.85 10.90 10 551369 122 79192887
Areflexia 14.85 10.90 10 551369 5524 79187485
Injection site laceration 14.78 10.90 10 551369 123 79192886
Neurological decompensation 14.77 10.90 9 551370 5244 79187765
Ovarian cyst 14.75 10.90 143 551236 12512 79180497
Blood chloride decreased 14.74 10.90 21 551358 8156 79184853
Endotracheal intubation 14.74 10.90 7 551372 4690 79188319
Scleroderma 14.72 10.90 10 551369 5500 79187509
Bronchial secretion retention 14.70 10.90 5 551374 4099 79188910
Cutaneous T-cell lymphoma stage II 14.67 10.90 7 551372 41 79192968
Acne 14.67 10.90 267 551112 26923 79166086
Aphthous ulcer 14.67 10.90 180 551199 16709 79176300
Hypertonia 14.66 10.90 17 551362 7215 79185794
Ischaemic cardiomyopathy 14.64 10.90 19 551360 7676 79185333
Infected dermal cyst 14.62 10.90 29 551350 1229 79191780
Sudden cardiac death 14.62 10.90 9 551370 5216 79187793
Blood parathyroid hormone increased 14.61 10.90 3 551376 3442 79189567
Ear injury 14.55 10.90 12 551367 203 79192806
Eye pruritus 14.53 10.90 83 551296 20487 79172522
Hereditary motor and sensory neuropathy 14.52 10.90 10 551369 127 79192882
Abscess sterile 14.51 10.90 8 551371 66 79192943
Rectal tube insertion 14.48 10.90 5 551374 10 79192999
Stridor 14.43 10.90 10 551369 5443 79187566
Skin infection 14.38 10.90 191 551188 18054 79174955
Haemoperitoneum 14.37 10.90 6 551373 4337 79188672
Fracture 14.33 10.90 90 551289 21711 79171298
Sigmoidectomy 14.31 10.90 8 551371 68 79192941
Osteochondrosis 14.29 10.90 38 551341 1958 79191051
Sputum increased 14.28 10.90 7 551372 4606 79188403
Bundle branch block left 14.26 10.90 37 551342 11476 79181533
Cardiac myxoma 14.26 10.90 10 551369 131 79192878
Injection site plaque 14.26 10.90 10 551369 131 79192878
Incorrect drug administration rate 14.25 10.90 5 551374 4021 79188988
Monocyte count increased 14.21 10.90 124 551255 10537 79182472
Vaginal haematoma 14.19 10.90 10 551369 132 79192877
Blood prolactin increased 14.17 10.90 5 551374 4006 79189003
Pleomorphic adenoma 14.17 10.90 5 551374 11 79192998
Upper-airway cough syndrome 14.16 10.90 38 551341 11655 79181354
Occult blood positive 14.15 10.90 16 551363 6867 79186142
Decreased interest 14.14 10.90 4 551375 3693 79189316
Cholelithiasis obstructive 14.14 10.90 7 551372 45 79192964
Throat tightness 14.13 10.90 124 551255 27783 79165226
Osteonecrosis 14.10 10.90 142 551237 30953 79162056
Gastroenteritis 14.10 10.90 159 551220 33923 79159086
Volvulus 14.09 10.90 47 551332 2749 79190260
Pupillary reflex impaired 14.05 10.90 3 551376 3350 79189659
Uterine cyst 14.04 10.90 14 551365 306 79192703
Walking aid user 14.03 10.90 119 551260 10029 79182980
Medical device site joint infection 14.02 10.90 15 551364 357 79192652
Candida infection 14.01 10.90 183 551196 38031 79154978
Tooth infection 13.96 10.90 195 551184 18637 79174372
Mouth ulceration 13.94 10.90 356 551023 38038 79154971
Skin warm 13.94 10.90 86 551293 6546 79186463
Nephropathy 13.91 10.90 29 551350 9709 79183300
Jugular vein thrombosis 13.88 10.90 7 551372 4531 79188478
Anaemia macrocytic 13.86 10.90 11 551368 5586 79187423
Benign neoplasm 13.85 10.90 26 551353 1057 79191952
Galactorrhoea 13.85 10.90 4 551375 3642 79189367
Lymphatic fistula 13.84 10.90 22 551357 781 79192228
Drug specific antibody absent 13.80 10.90 12 551367 219 79192790
Embolism venous 13.79 10.90 6 551373 4233 79188776
Gastrointestinal anastomotic leak 13.79 10.90 18 551361 532 79192477
Product label confusion 13.78 10.90 33 551346 1593 79191416
Cardiopulmonary failure 13.78 10.90 16 551363 6785 79186224
Libido decreased 13.77 10.90 10 551369 5311 79187698
Anal cancer 13.76 10.90 22 551357 785 79192224
Hair colour changes 13.76 10.90 6 551373 4226 79188783
Benign hepatic neoplasm 13.74 10.90 8 551371 74 79192935
Effusion 13.73 10.90 40 551339 2174 79190835
Colon operation 13.72 10.90 16 551363 420 79192589
Pelvic pouch procedure 13.71 10.90 4 551375 3 79193006
Cutaneous tuberculosis 13.71 10.90 12 551367 221 79192788
Ileocolostomy 13.71 10.90 4 551375 3 79193006
Testicular germ cell cancer 13.71 10.90 4 551375 3 79193006
Purpura 13.68 10.90 79 551300 19448 79173561
Lacrimation increased 13.66 10.90 95 551284 22382 79170627
Ganglioneuroma 13.64 10.90 10 551369 141 79192868
Cardiolipin antibody positive 13.64 10.90 11 551368 180 79192829
Hemiplegia 13.63 10.90 55 551324 14884 79178125
Underdose 13.58 10.90 155 551224 32996 79160013
Bilirubin conjugated increased 13.58 10.90 11 551368 5528 79187481
N-terminal prohormone brain natriuretic peptide increased 13.57 10.90 8 551371 4747 79188262
Intervertebral disc operation 13.56 10.90 24 551355 932 79192077
Pharyngeal neoplasm 13.51 10.90 6 551373 29 79192980
Acute coronary syndrome 13.50 10.90 88 551291 21045 79171964
Abortion 13.47 10.90 30 551349 1380 79191629
Cold sweat 13.45 10.90 75 551304 18624 79174385
Liver transplant rejection 13.42 10.90 3 551376 3245 79189764
Haematocrit decreased 13.38 10.90 322 551057 60990 79132019
Multiple system atrophy 13.38 10.90 15 551364 377 79192632
Large intestine erosion 13.34 10.90 6 551373 30 79192979
Bacterial infection 13.31 10.90 145 551234 31135 79161874
Stoma creation 13.30 10.90 8 551371 79 79192930
Dilatation ventricular 13.27 10.90 6 551373 4138 79188871
Petit mal epilepsy 13.27 10.90 12 551367 5715 79187294
Meningioma benign 13.27 10.90 13 551366 278 79192731
Keratoacanthoma 13.26 10.90 25 551354 1020 79191989
Tuberculosis of eye 13.22 10.90 8 551371 80 79192929
Product residue present 13.21 10.90 4 551375 3532 79189477
Ovarian adenoma 13.19 10.90 12 551367 233 79192776
Incision site pruritus 13.19 10.90 6 551373 31 79192978
Spleen tuberculosis 13.19 10.90 6 551373 31 79192978
Perfusion brain scan abnormal 13.18 10.90 4 551375 4 79193005
Cutaneous B-cell lymphoma 13.18 10.90 4 551375 4 79193005
Eosinophil morphology abnormal 13.18 10.90 4 551375 4 79193005
Arteriosclerosis 13.17 10.90 73 551306 18154 79174855
Plasmacytoma 13.15 10.90 7 551372 4396 79188613
Endophthalmitis 13.15 10.90 15 551364 6413 79186596
Speech sound disorder 13.09 10.90 7 551372 54 79192955
Left ventricular hypertrophy 13.08 10.90 37 551342 11154 79181855
Arthritis infective 13.07 10.90 100 551279 8171 79184838
Femoral hernia incarcerated 13.07 10.90 22 551357 820 79192189
Allergic respiratory symptom 13.07 10.90 10 551369 151 79192858
Arnold-Chiari malformation 13.05 10.90 11 551368 192 79192817
Laryngeal cancer 13.04 10.90 21 551358 754 79192255
Photosensitivity reaction 13.04 10.90 212 551167 20915 79172094
Alopecia universalis 13.01 10.90 13 551366 285 79192724
Paralysis 13.00 10.90 47 551332 13130 79179879
Communication disorder 12.98 10.90 6 551373 4084 79188925
Staphylococcal abscess 12.93 10.90 26 551353 1113 79191896
Neoplasm skin 12.91 10.90 32 551347 1579 79191430
Hepatitis toxic 12.89 10.90 10 551369 5137 79187872
Genital cyst 12.87 10.90 7 551372 56 79192953
Atypical fibroxanthoma 12.86 10.90 11 551368 196 79192813
Ligament rupture 12.84 10.90 52 551327 3342 79189667
Stenotrophomonas infection 12.83 10.90 5 551374 3768 79189241
Hepatic cyst 12.82 10.90 79 551300 6010 79186999
Collagen-vascular disease 12.81 10.90 8 551371 85 79192924
Hepatitis B reactivation 12.78 10.90 14 551365 6094 79186915
Infectious mononucleosis 12.77 10.90 37 551342 2005 79191004
Homicidal ideation 12.75 10.90 4 551375 3453 79189556
Nasal septum deviation 12.75 10.90 35 551344 1838 79191171
Cartilage injury 12.74 10.90 31 551348 1512 79191497
Dry throat 12.73 10.90 21 551358 7685 79185324
SLE arthritis 12.73 10.90 18 551361 575 79192434
Cushingoid 12.68 10.90 111 551268 9441 79183568
Cutaneous sarcoidosis 12.67 10.90 16 551363 457 79192552
Electrocardiogram T wave abnormal 12.63 10.90 5 551374 3733 79189276
Limb fracture 12.60 10.90 6 551373 35 79192974
Rectal cancer metastatic 12.59 10.90 16 551363 460 79192549
Groin abscess 12.58 10.90 31 551348 1524 79191485
Supraventricular extrasystoles 12.54 10.90 18 551361 6969 79186040
Mean cell haemoglobin concentration abnormal 12.48 10.90 10 551369 162 79192847
Synovial disorder 12.46 10.90 36 551343 1947 79191062
Human anti-human antibody test 12.45 10.90 15 551364 408 79192601
Stem cell transplant 12.44 10.90 5 551374 3699 79189310
B-cell lymphoma stage IV 12.43 10.90 8 551371 90 79192919
Eye naevus 12.40 10.90 5 551374 18 79192991
Cellulitis staphylococcal 12.40 10.90 26 551353 1147 79191862
Thyroid neoplasm 12.39 10.90 49 551330 3115 79189894
Metabolic surgery 12.38 10.90 26 551353 1148 79191861
Eye swelling 12.37 10.90 120 551259 26348 79166661
Wisdom teeth removal 12.36 10.90 16 551363 469 79192540
Dermatofibrosarcoma protuberans 12.33 10.90 6 551373 37 79192972
Breast calcifications 12.33 10.90 22 551357 860 79192149
Abortion incomplete 12.32 10.90 3 551376 3061 79189948
Impetigo 12.31 10.90 37 551342 2046 79190963
Gastrointestinal bacterial infection 12.31 10.90 23 551356 932 79192077
Plantar fasciitis 12.30 10.90 52 551327 3408 79189601
Peripheral motor neuropathy 12.24 10.90 4 551375 3363 79189646
Hyperkaliuria 12.18 10.90 10 551369 168 79192841
Nodular melanoma 12.18 10.90 10 551369 168 79192841
Therapeutic product effect variable 12.17 10.90 36 551343 1973 79191036
Upper respiratory tract infection 12.14 10.90 758 550621 90410 79102599
Cardiomegaly 12.09 10.90 120 551259 26232 79166777
Q fever 12.08 10.90 12 551367 261 79192748
Gastric banding 12.07 10.90 6 551373 39 79192970
Lymphoid tissue hyperplasia 12.01 10.90 12 551367 263 79192746
Pustule 12.00 10.90 36 551343 1989 79191020
Congenital knee deformity 12.00 10.90 5 551374 20 79192989
Dyspnoea at rest 11.97 10.90 20 551359 7282 79185727
Tuberculosis of intrathoracic lymph nodes 11.94 10.90 3 551376 0 79193009
Congenital naevus 11.94 10.90 3 551376 0 79193009
Reticular erythematous mucinosis 11.94 10.90 3 551376 0 79193009
Mammary fistula 11.94 10.90 3 551376 0 79193009
Neoplasm of orbit 11.94 10.90 3 551376 0 79193009
Oesophageal papilloma 11.94 10.90 3 551376 0 79193009
Benign neoplasm of prostate 11.94 10.90 3 551376 0 79193009
Laryngeal dysplasia 11.94 10.90 3 551376 0 79193009
Intervertebral disc calcification 11.94 10.90 3 551376 0 79193009
Seminal vesicular disorder 11.94 10.90 3 551376 0 79193009
Cerebrospinal fistula 11.94 10.90 3 551376 0 79193009
Adenosine deaminase increased 11.94 10.90 3 551376 0 79193009
Magnetic resonance imaging abdominal abnormal 11.94 10.90 3 551376 0 79193009
Gastrointestinal anastomotic complication 11.94 10.90 3 551376 0 79193009
Ulnar neuritis 11.94 10.90 3 551376 0 79193009
Small intestinal anastomosis 11.94 10.90 3 551376 0 79193009
Orbital granuloma 11.94 10.90 3 551376 0 79193009
Autoimmune demyelinating disease 11.94 10.90 3 551376 0 79193009
Meningitis leptospiral 11.94 10.90 3 551376 0 79193009
Dirofilariasis 11.94 10.90 3 551376 0 79193009
Gastroenteritis shigella 11.94 10.90 3 551376 0 79193009
Nodular lymphocyte predominant Hodgkin lymphoma 11.94 10.90 3 551376 0 79193009
Fallopian tube operation 11.93 10.90 4 551375 7 79193002
Akinesia 11.92 10.90 4 551375 3308 79189701
Red blood cell sedimentation rate decreased 11.90 10.90 12 551367 266 79192743
Streptococcal bacteraemia 11.90 10.90 5 551374 3601 79189408
Panic disorder 11.90 10.90 3 551376 2989 79190020
Atypical femur fracture 11.87 10.90 11 551368 5178 79187831
Eating disorder 11.84 10.90 89 551290 20608 79172401
Abortion induced 11.83 10.90 87 551292 7022 79185987
Tooth disorder 11.81 10.90 120 551259 26113 79166896
Amenorrhoea 11.77 10.90 22 551357 7670 79185339
Sputum discoloured 11.74 10.90 95 551284 21648 79171361
Cardiac dysfunction 11.68 10.90 7 551372 4117 79188892
Femoral neck fracture 11.68 10.90 33 551346 9951 79183058
Fixed eruption 11.67 10.90 3 551376 2951 79190058
Hyperpyrexia 11.64 10.90 15 551364 6077 79186932
Testicular seminoma (pure) stage I 11.63 10.90 5 551374 22 79192987
Gastritis 11.62 10.90 248 551131 47745 79145264
Pseudomembranous colitis 11.60 10.90 12 551367 5362 79187647
Behaviour disorder 11.59 10.90 16 551363 6297 79186712
Muscle operation 11.59 10.90 4 551375 8 79193001
Tendon sheath incision 11.58 10.90 6 551373 43 79192966
Neoplasm prostate 11.57 10.90 10 551369 181 79192828
Logorrhoea 11.56 10.90 8 551371 4357 79188652
Suicidal behaviour 11.55 10.90 4 551375 3243 79189766
Blood urine present 11.52 10.90 93 551286 21204 79171805
Gastrointestinal erosion 11.52 10.90 24 551355 1054 79191955
Blindness 11.51 10.90 133 551246 28250 79164759
Swollen tongue 11.50 10.90 216 551163 42354 79150655
Contusion 11.48 10.90 1186 550193 147590 79045419
Swelling of eyelid 11.47 10.90 6 551373 3805 79189204
Thyroiditis 11.47 10.90 9 551370 4596 79188413
Thyroid cancer 11.46 10.90 72 551307 5516 79187493
Hyperthermia malignant 11.45 10.90 3 551376 2914 79190095
False positive tuberculosis test 11.45 10.90 5 551374 23 79192986
Troponin T increased 11.44 10.90 5 551374 3517 79189492
Skin abrasion 11.38 10.90 51 551328 13405 79179604
Initial insomnia 11.38 10.90 19 551360 6919 79186090
Cholecystitis acute 11.36 10.90 51 551328 13400 79179609
Seroconversion test positive 11.36 10.90 6 551373 45 79192964
Oxygen saturation abnormal 11.36 10.90 9 551370 4573 79188436
Device deployment issue 11.35 10.90 4 551375 3208 79189801
Mesenteric abscess 11.33 10.90 9 551370 144 79192865
Product administered to patient of inappropriate age 11.32 10.90 13 551366 5540 79187469
Premature baby 11.31 10.90 6 551373 3774 79189235
Anal squamous cell carcinoma 11.30 10.90 17 551362 575 79192434
Psoas abscess 11.29 10.90 23 551356 994 79192015
Abdominal hernia 11.29 10.90 72 551307 5544 79187465
Respiratory alkalosis 11.29 10.90 8 551371 4303 79188706
Hypoproteinaemia 11.28 10.90 7 551372 4039 79188970
Neuritis cranial 11.27 10.90 4 551375 9 79193000
Vaginal operation 11.27 10.90 4 551375 9 79193000
Benign lymph node neoplasm 11.27 10.90 4 551375 9 79193000
Neobladder surgery 11.27 10.90 4 551375 9 79193000
Adenocarcinoma 11.27 10.90 55 551324 3831 79189178
Haemorrhage subcutaneous 11.24 10.90 10 551369 4799 79188210
Embolism 11.23 10.90 54 551325 13928 79179081
Pseudarthrosis 11.20 10.90 12 551367 286 79192723
Staphylococcal skin infection 11.18 10.90 30 551349 1554 79191455
Soft tissue swelling 11.18 10.90 29 551350 1472 79191537
Bruxism 11.17 10.90 7 551372 4019 79188990
Viraemia 11.17 10.90 3 551376 2866 79190143
Concomitant disease progression 11.17 10.90 5 551374 3468 79189541
Deafness 11.15 10.90 206 551173 20831 79172178
Pneumonitis chemical 11.14 10.90 15 551364 457 79192552
Genital hypoaesthesia 11.12 10.90 10 551369 191 79192818
Chronic cutaneous lupus erythematosus 11.09 10.90 15 551364 459 79192550
Tumour marker increased 11.09 10.90 8 551371 4264 79188745
Sneezing 11.09 10.90 85 551294 19598 79173411
Pleurisy 11.07 10.90 116 551263 10359 79182650
Catheterisation cardiac 11.05 10.90 14 551365 5714 79187295
Adjustment disorder 11.04 10.90 7 551372 3993 79189016
Adnexa uteri cyst 11.04 10.90 6 551373 48 79192961
Non-Hodgkin's lymphoma stage IV 11.04 10.90 6 551373 48 79192961
Benign salivary gland neoplasm 11.04 10.90 6 551373 48 79192961
Bacterial vulvovaginitis 11.02 10.90 17 551362 588 79192421
Myoglobin blood increased 11.01 10.90 4 551375 3147 79189862
Follicular thyroid cancer 11.01 10.90 7 551372 77 79192932
Exposed bone in jaw 10.99 10.90 6 551373 3714 79189295
Glomerulonephritis 10.99 10.90 50 551329 3383 79189626
Injection site induration 10.98 10.90 110 551269 9709 79183300
Myelitis transverse 10.96 10.90 34 551345 1913 79191096
Drooling 10.94 10.90 15 551364 5919 79187090
Neoplasm of appendix 10.93 10.90 6 551373 49 79192960
Lupus vulgaris 10.91 10.90 49 551330 3297 79189712
Herpes simplex hepatitis 10.90 10.90 16 551363 529 79192480

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AB04 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Tumor necrosis factor alpha (TNF-alpha) inhibitors
FDA CS M0001357 Antibodies, Monoclonal
FDA MoA N0000175451 Tumor Necrosis Factor Receptor Blocking Activity
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D000079424 Tumor Necrosis Factor Inhibitors
FDA EPC N0000175610 Tumor Necrosis Factor Blocker

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Hidradenitis suppurativa indication 59393003 DOID:2280
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Pyoderma gangrenosum indication 74578003 DOID:8553
Psoriatic arthritis indication 156370009 DOID:9008
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Non-infectious anterior uveitis indication 267619000
Behcet's disease indication 310701003 DOID:13241
Juvenile idiopathic arthritis indication 410502007
Axial spondyloarthritis indication 723116002
Non-infectious intermediate, posterior and panuveitis indication 733337008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tumor necrosis factor Cytokine ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
FYS6T7F842 UNII
D02597 KEGG_DRUG
4021370 VUID
N0000148789 NUI
4021370 VANDF
4042009 VANDF
4042360 VANDF
C1122087 UMLSCUI
CHEMBL1201580 ChEMBL_ID
DB00051 DRUGBANK_ID
D000068879 MESH_DESCRIPTOR_UI
7860 INN_ID
4860 IUPHAR_LIGAND_ID
2103477 RXNORM
17071 MMSL
248487 MMSL
33375 MMSL
33385 MMSL
368840 MMSL
45825 MMSL
d04835 MMSL
009871 NDDF
016993 NDDF
017321 NDDF
398728003 SNOMEDCT_US
407317001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Humira HUMAN PRESCRIPTION DRUG LABEL 1 0074-3797 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 33 sections
Humira HUMAN PRESCRIPTION DRUG LABEL 1 0074-3797 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 33 sections
Humira HUMAN PRESCRIPTION DRUG LABEL 1 0074-3797 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 33 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 50090-6411 INJECTION 40 mg SUBCUTANEOUS BLA 33 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 50090-6428 INJECTION 40 mg SUBCUTANEOUS BLA 33 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 55513-399 INJECTION 20 mg SUBCUTANEOUS BLA 34 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 55513-400 INJECTION 40 mg SUBCUTANEOUS BLA 34 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 55513-410 INJECTION 40 mg SUBCUTANEOUS BLA 34 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 55513-411 INJECTION 20 mg SUBCUTANEOUS BLA 34 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 55513-413 INJECTION 10 mg SUBCUTANEOUS BLA 34 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 55513-479 INJECTION 40 mg SUBCUTANEOUS BLA 34 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 55513-480 INJECTION 80 mg SUBCUTANEOUS BLA 34 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 55513-481 INJECTION 80 mg SUBCUTANEOUS BLA 34 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 55513-482 INJECTION 40 mg SUBCUTANEOUS BLA 34 sections
Adalimumab HUMAN PRESCRIPTION DRUG LABEL 1 61314-327 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 30 sections
HYRIMOZ HUMAN PRESCRIPTION DRUG LABEL 1 61314-454 INJECTION, SOLUTION 80 mg SUBCUTANEOUS BLA 30 sections
HYRIMOZ HUMAN PRESCRIPTION DRUG LABEL 1 61314-473 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 30 sections
HYRIMOZ HUMAN PRESCRIPTION DRUG LABEL 1 61314-476 INJECTION, SOLUTION 20 mg SUBCUTANEOUS BLA 30 sections
HYRIMOZ HUMAN PRESCRIPTION DRUG LABEL 1 61314-509 INJECTION, SOLUTION 10 mg SUBCUTANEOUS BLA 30 sections
SB5 (BIIB606) HUMAN PRESCRIPTION DRUG LABEL 1 61434-005 INJECTION, SOLUTION 40 mg INTRAVENOUS export only 1 sections
SB5 (BIIB606) HUMAN PRESCRIPTION DRUG LABEL 1 61434-005 INJECTION, SOLUTION 40 mg INTRAVENOUS export only 1 sections
Abrilada HUMAN PRESCRIPTION DRUG LABEL 1 61434-053 INJECTION, SOLUTION 20 mg SUBCUTANEOUS export only 1 sections
Abrilada HUMAN PRESCRIPTION DRUG LABEL 1 61434-053 INJECTION, SOLUTION 20 mg SUBCUTANEOUS export only 1 sections
Idacio HUMAN PRESCRIPTION DRUG LABEL 1 65219-554 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 31 sections
Idacio HUMAN PRESCRIPTION DRUG LABEL 1 65219-556 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 31 sections
YUSIMRY HUMAN PRESCRIPTION DRUG LABEL 1 70114-210 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 31 sections
YUSIMRY HUMAN PRESCRIPTION DRUG LABEL 1 70114-220 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 31 sections
Imraldi HUMAN PRESCRIPTION DRUG LABEL 1 71202-002 INJECTION, SOLUTION 40 mg SUBCUTANEOUS Export only 30 sections
AMJEVITA HUMAN PRESCRIPTION DRUG LABEL 1 72511-400 INJECTION 40 mg SUBCUTANEOUS BLA 34 sections
Yuflyma HUMAN PRESCRIPTION DRUG LABEL 1 72606-030 INJECTION 40 mg SUBCUTANEOUS BLA 33 sections