| Stem definition | Drug id | CAS RN |
|---|---|---|
| humanized origin | 4971 | 347396-82-1 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A recombinant humanized monoclonal antibody fragment that binds VEGF-A to prevent its binding to VEGFR-1 and VEGFR-2 receptors. This activity reduces vessel permeability and angiogenesis in the treatment of neovascular age-related MACULAR DEGENERATION.
|
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 22, 2007 | EMA | Novartis Europharm Limited | |
| June 30, 2006 | FDA | GENENTECH | |
| Jan. 21, 2009 | PMDA | Novartis Pharma |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Visual acuity reduced | 2833.52 | 25.15 | 724 | 15221 | 21102 | 63451975 |
| Endophthalmitis | 1249.73 | 25.15 | 266 | 15679 | 3326 | 63469751 |
| Death | 1206.42 | 25.15 | 882 | 15063 | 373499 | 63099578 |
| Retinal haemorrhage | 884.44 | 25.15 | 213 | 15732 | 4756 | 63468321 |
| Cerebrovascular accident | 779.29 | 25.15 | 426 | 15519 | 107598 | 63365479 |
| Blindness | 736.94 | 25.15 | 256 | 15689 | 21443 | 63451634 |
| Retinal pigment epithelial tear | 708.09 | 25.15 | 110 | 15835 | 149 | 63472928 |
| Detachment of retinal pigment epithelium | 675.47 | 25.15 | 112 | 15833 | 284 | 63472793 |
| Eye haemorrhage | 634.81 | 25.15 | 183 | 15762 | 8313 | 63464764 |
| Vitreous floaters | 570.95 | 25.15 | 156 | 15789 | 5810 | 63467267 |
| Retinal oedema | 553.79 | 25.15 | 103 | 15842 | 598 | 63472479 |
| Visual impairment | 550.73 | 25.15 | 312 | 15633 | 84134 | 63388943 |
| Macular oedema | 527.41 | 25.15 | 134 | 15811 | 3743 | 63469334 |
| Eye pain | 489.36 | 25.15 | 215 | 15730 | 33639 | 63439438 |
| Vitreous haemorrhage | 486.35 | 25.15 | 111 | 15834 | 1939 | 63471138 |
| Age-related macular degeneration | 419.64 | 25.15 | 82 | 15863 | 641 | 63472436 |
| Subretinal fluid | 404.18 | 25.15 | 74 | 15871 | 388 | 63472689 |
| Photopsia | 354.01 | 25.15 | 101 | 15844 | 4408 | 63468669 |
| Metamorphopsia | 352.72 | 25.15 | 77 | 15868 | 1086 | 63471991 |
| Eye discharge | 341.37 | 25.15 | 105 | 15840 | 5958 | 63467119 |
| Eye pruritus | 300.44 | 25.15 | 128 | 15817 | 18543 | 63454534 |
| Choroidal neovascularisation | 278.42 | 25.15 | 51 | 15894 | 268 | 63472809 |
| Vision blurred | 277.84 | 25.15 | 210 | 15735 | 91714 | 63381363 |
| Intraocular pressure increased | 266.49 | 25.15 | 87 | 15858 | 5991 | 63467086 |
| Polypoidal choroidal vasculopathy | 236.54 | 25.15 | 36 | 15909 | 38 | 63473039 |
| Retinal exudates | 226.03 | 25.15 | 49 | 15896 | 667 | 63472410 |
| Eye irritation | 222.04 | 25.15 | 109 | 15836 | 21862 | 63451215 |
| Transient ischaemic attack | 220.30 | 25.15 | 130 | 15815 | 37623 | 63435454 |
| Retinal detachment | 220.12 | 25.15 | 75 | 15870 | 5894 | 63467183 |
| Retinal thickening | 215.16 | 25.15 | 31 | 15914 | 13 | 63473064 |
| Myocardial infarction | 214.55 | 25.15 | 187 | 15758 | 99706 | 63373371 |
| Cystoid macular oedema | 211.97 | 25.15 | 54 | 15891 | 1521 | 63471556 |
| Macular hole | 207.60 | 25.15 | 47 | 15898 | 789 | 63472288 |
| Vitritis | 194.36 | 25.15 | 46 | 15899 | 946 | 63472131 |
| Eye inflammation | 189.56 | 25.15 | 66 | 15879 | 5533 | 63467544 |
| Dry throat | 181.04 | 25.15 | 67 | 15878 | 6698 | 63466379 |
| Vitreous detachment | 179.95 | 25.15 | 50 | 15895 | 1977 | 63471100 |
| Subretinal fibrosis | 165.90 | 25.15 | 27 | 15918 | 58 | 63473019 |
| Macular fibrosis | 165.02 | 25.15 | 34 | 15911 | 356 | 63472721 |
| Non-infectious endophthalmitis | 164.51 | 25.15 | 30 | 15915 | 153 | 63472924 |
| Retinal vein occlusion | 163.68 | 25.15 | 47 | 15898 | 2096 | 63470981 |
| Retinal scar | 157.17 | 25.15 | 28 | 15917 | 122 | 63472955 |
| Retinal depigmentation | 156.45 | 25.15 | 31 | 15914 | 262 | 63472815 |
| Blindness unilateral | 153.11 | 25.15 | 58 | 15887 | 6183 | 63466894 |
| Ocular hyperaemia | 153 | 25.15 | 89 | 15856 | 25055 | 63448022 |
| Retinal disorder | 146.87 | 25.15 | 41 | 15904 | 1649 | 63471428 |
| Pharyngeal oedema | 141.37 | 25.15 | 69 | 15876 | 13652 | 63459425 |
| Cataract nuclear | 140.80 | 25.15 | 35 | 15910 | 890 | 63472187 |
| Cerebral infarction | 138.60 | 25.15 | 82 | 15863 | 23811 | 63449266 |
| Retinal neovascularisation | 133.27 | 25.15 | 21 | 15924 | 33 | 63473044 |
| Anterior chamber cell | 131.92 | 25.15 | 30 | 15915 | 514 | 63472563 |
| Macular degeneration | 129.34 | 25.15 | 79 | 15866 | 24297 | 63448780 |
| Cataract | 126.78 | 25.15 | 109 | 15836 | 56944 | 63416133 |
| Retinal cyst | 126.66 | 25.15 | 21 | 15924 | 53 | 63473024 |
| Retinal degeneration | 122.19 | 25.15 | 31 | 15914 | 858 | 63472219 |
| Vitreous opacities | 118.06 | 25.15 | 25 | 15920 | 302 | 63472775 |
| Uveitis | 117.08 | 25.15 | 59 | 15886 | 12494 | 63460583 |
| Iridocyclitis | 114.18 | 25.15 | 37 | 15908 | 2485 | 63470592 |
| Retinal artery occlusion | 111.84 | 25.15 | 33 | 15912 | 1620 | 63471457 |
| Macular scar | 110.33 | 25.15 | 20 | 15925 | 98 | 63472979 |
| Ocular hypertension | 107.60 | 25.15 | 29 | 15916 | 1021 | 63472056 |
| Visual field defect | 105.53 | 25.15 | 45 | 15900 | 6516 | 63466561 |
| Retinal ischaemia | 104.76 | 25.15 | 23 | 15922 | 333 | 63472744 |
| Vitreous disorder | 93.33 | 25.15 | 17 | 15928 | 86 | 63472991 |
| Retinal tear | 92.68 | 25.15 | 27 | 15918 | 1267 | 63471810 |
| Throat tightness | 86.61 | 25.15 | 62 | 15883 | 24825 | 63448252 |
| Retinal vascular disorder | 81.99 | 25.15 | 17 | 15928 | 184 | 63472893 |
| Disease progression | 81.09 | 25.15 | 125 | 15820 | 122633 | 63350444 |
| Diarrhoea | 80.19 | 25.15 | 40 | 15905 | 715326 | 62757751 |
| Fatigue | 79.93 | 25.15 | 64 | 15881 | 887964 | 62585113 |
| Retinal aneurysm | 75.42 | 25.15 | 16 | 15929 | 195 | 63472882 |
| Dry age-related macular degeneration | 74.19 | 25.15 | 16 | 15929 | 212 | 63472865 |
| Macular pigmentation | 70.73 | 25.15 | 11 | 15934 | 15 | 63473062 |
| Lacrimation increased | 68.59 | 25.15 | 50 | 15895 | 20581 | 63452496 |
| Cutis laxa | 67.82 | 25.15 | 14 | 15931 | 148 | 63472929 |
| Foreign body sensation in eyes | 66.72 | 25.15 | 24 | 15921 | 2210 | 63470867 |
| Rash | 66.42 | 25.15 | 29 | 15916 | 560842 | 62912235 |
| Alopecia | 65.82 | 25.15 | 5 | 15940 | 337531 | 63135546 |
| Glaucoma | 63.26 | 25.15 | 46 | 15899 | 18859 | 63454218 |
| Foreign body in eye | 62.93 | 25.15 | 13 | 15932 | 138 | 63472939 |
| Neovascular age-related macular degeneration | 62.75 | 25.15 | 14 | 15931 | 219 | 63472858 |
| Eye oedema | 59.57 | 25.15 | 20 | 15925 | 1500 | 63471577 |
| Ophthalmological examination abnormal | 58.66 | 25.15 | 11 | 15934 | 67 | 63473010 |
| Ischaemic stroke | 58.52 | 25.15 | 43 | 15902 | 17914 | 63455163 |
| Eye infection | 55.94 | 25.15 | 36 | 15909 | 12109 | 63460968 |
| Hypopyon | 55.65 | 25.15 | 16 | 15929 | 716 | 63472361 |
| Ocular discomfort | 55.02 | 25.15 | 25 | 15920 | 4208 | 63468869 |
| Choroidal haemorrhage | 54.83 | 25.15 | 10 | 15935 | 51 | 63473026 |
| Diabetic retinopathy | 54.81 | 25.15 | 21 | 15924 | 2306 | 63470771 |
| Posterior capsule opacification | 54.69 | 25.15 | 11 | 15934 | 101 | 63472976 |
| Drug intolerance | 53.84 | 25.15 | 7 | 15938 | 308654 | 63164423 |
| No adverse event | 52.16 | 25.15 | 58 | 15887 | 41347 | 63431730 |
| Maculopathy | 51.80 | 25.15 | 20 | 15925 | 2242 | 63470835 |
| Anterior chamber flare | 51.64 | 25.15 | 10 | 15935 | 74 | 63473003 |
| Blepharitis | 51.60 | 25.15 | 21 | 15924 | 2704 | 63470373 |
| Joint swelling | 51.38 | 25.15 | 10 | 15935 | 327656 | 63145421 |
| Pain | 51.04 | 25.15 | 67 | 15878 | 740561 | 62732516 |
| Eye disorder | 49.65 | 25.15 | 43 | 15902 | 22642 | 63450435 |
| Conjunctival haemorrhage | 49.22 | 25.15 | 22 | 15923 | 3565 | 63469512 |
| Conjunctival erosion | 47.75 | 25.15 | 10 | 15935 | 114 | 63472963 |
| Retinal fibrosis | 46.70 | 25.15 | 7 | 15938 | 6 | 63473071 |
| Rheumatoid arthritis | 46.13 | 25.15 | 5 | 15940 | 253814 | 63219263 |
| Tachyphylaxis | 44.81 | 25.15 | 11 | 15934 | 265 | 63472812 |
| Pyrexia | 44.59 | 25.15 | 32 | 15913 | 470446 | 63002631 |
| Retinoschisis | 44.42 | 25.15 | 7 | 15938 | 11 | 63473066 |
| Suspected transmission of an infectious agent via product | 43.83 | 25.15 | 11 | 15934 | 291 | 63472786 |
| Anterior chamber inflammation | 42.96 | 25.15 | 11 | 15934 | 316 | 63472761 |
| Arthralgia | 42.94 | 25.15 | 48 | 15897 | 569662 | 62903415 |
| Retinopathy proliferative | 42.35 | 25.15 | 8 | 15937 | 51 | 63473026 |
| Dysphonia | 40.94 | 25.15 | 55 | 15890 | 47559 | 63425518 |
| Visual acuity tests abnormal | 40.87 | 25.15 | 8 | 15937 | 63 | 63473014 |
| Exudative retinopathy | 40.68 | 25.15 | 6 | 15939 | 4 | 63473073 |
| Abdominal discomfort | 40.51 | 25.15 | 15 | 15930 | 320870 | 63152207 |
| Conjunctival bleb | 40.40 | 25.15 | 7 | 15938 | 25 | 63473052 |
| Disease recurrence | 40.10 | 25.15 | 42 | 15903 | 27988 | 63445089 |
| Arthropathy | 39.34 | 25.15 | 6 | 15939 | 234786 | 63238291 |
| Macular ischaemia | 39.01 | 25.15 | 7 | 15938 | 32 | 63473045 |
| Weight increased | 38.73 | 25.15 | 9 | 15936 | 260783 | 63212294 |
| Vitrectomy | 38.64 | 25.15 | 9 | 15936 | 172 | 63472905 |
| Treatment failure | 38.62 | 25.15 | 3 | 15942 | 199040 | 63274037 |
| Atrial fibrillation | 38.20 | 25.15 | 88 | 15857 | 116548 | 63356529 |
| Dry eye | 38.01 | 25.15 | 49 | 15896 | 40712 | 63432365 |
| Retinal drusen | 37.15 | 25.15 | 6 | 15939 | 12 | 63473065 |
| Vomiting | 37.09 | 25.15 | 52 | 15893 | 559565 | 62913512 |
| Vitreous adhesions | 36.61 | 25.15 | 7 | 15938 | 48 | 63473029 |
| Swelling | 36.25 | 25.15 | 12 | 15933 | 275366 | 63197711 |
| Photophobia | 35.74 | 25.15 | 32 | 15913 | 17603 | 63455474 |
| Staphylococcus test positive | 35.41 | 25.15 | 18 | 15927 | 3878 | 63469199 |
| Vitreous degeneration | 35.18 | 25.15 | 6 | 15939 | 19 | 63473058 |
| Hypotony of eye | 34.59 | 25.15 | 8 | 15937 | 148 | 63472929 |
| Peripheral swelling | 34.29 | 25.15 | 12 | 15933 | 265930 | 63207147 |
| Angina pectoris | 34.26 | 25.15 | 40 | 15905 | 30038 | 63443039 |
| Glare | 34.17 | 25.15 | 7 | 15938 | 71 | 63473006 |
| Corneal striae | 34.10 | 25.15 | 5 | 15940 | 3 | 63473074 |
| Myocardial ischaemia | 33.58 | 25.15 | 27 | 15918 | 12832 | 63460245 |
| Corneal oedema | 33.48 | 25.15 | 13 | 15932 | 1480 | 63471597 |
| Intraocular lens implant | 32.93 | 25.15 | 9 | 15936 | 334 | 63472743 |
| Product use issue | 32.29 | 25.15 | 125 | 15820 | 220395 | 63252682 |
| Macular detachment | 32.17 | 25.15 | 7 | 15938 | 97 | 63472980 |
| Hypertensive crisis | 31.49 | 25.15 | 28 | 15917 | 15258 | 63457819 |
| Sinusitis | 31.40 | 25.15 | 9 | 15936 | 226644 | 63246433 |
| Haemorrhagic stroke | 31.29 | 25.15 | 19 | 15926 | 5773 | 63467304 |
| Pruritus | 31.17 | 25.15 | 27 | 15918 | 361426 | 63111651 |
| Charles Bonnet syndrome | 30.96 | 25.15 | 5 | 15940 | 10 | 63473067 |
| Inappropriate schedule of product administration | 30.32 | 25.15 | 75 | 15870 | 103890 | 63369187 |
| Dyspnoea | 30.15 | 25.15 | 77 | 15868 | 661236 | 62811841 |
| Therapeutic product effect decreased | 30.03 | 25.15 | 6 | 15939 | 193181 | 63279896 |
| Choroidal effusion | 30.01 | 25.15 | 9 | 15936 | 467 | 63472610 |
| Iritis | 29.82 | 25.15 | 15 | 15930 | 3160 | 63469917 |
| Acute myocardial infarction | 28.99 | 25.15 | 38 | 15907 | 32086 | 63440991 |
| Drug interaction | 28.41 | 25.15 | 11 | 15934 | 229120 | 63243957 |
| Cataract subcapsular | 27.99 | 25.15 | 9 | 15936 | 589 | 63472488 |
| Abdominal pain | 27.71 | 25.15 | 20 | 15925 | 293436 | 63179641 |
| Retinal vasculitis | 27.35 | 25.15 | 10 | 15935 | 964 | 63472113 |
| Weight decreased | 27.28 | 25.15 | 18 | 15927 | 276780 | 63196297 |
| Posterior capsule rupture | 26.92 | 25.15 | 4 | 15941 | 3 | 63473074 |
| Infection | 26.81 | 25.15 | 12 | 15933 | 229161 | 63243916 |
| Choroidal detachment | 26.64 | 25.15 | 7 | 15938 | 223 | 63472854 |
| Macular cyst | 26.59 | 25.15 | 5 | 15940 | 31 | 63473046 |
| Decreased appetite | 26.59 | 25.15 | 15 | 15930 | 251037 | 63222040 |
| Retinal injury | 26.23 | 25.15 | 7 | 15938 | 237 | 63472840 |
| Completed suicide | 26.12 | 25.15 | 3 | 15942 | 145670 | 63327407 |
| Corneal opacity | 26.07 | 25.15 | 9 | 15936 | 734 | 63472343 |
| Conjunctival disorder | 25.98 | 25.15 | 7 | 15938 | 246 | 63472831 |
| Constipation | 25.97 | 25.15 | 12 | 15933 | 224931 | 63248146 |
| Corneal abrasion | 25.96 | 25.15 | 10 | 15935 | 1114 | 63471963 |
| Pain in extremity | 25.95 | 25.15 | 27 | 15918 | 331459 | 63141618 |
| Normal tension glaucoma | 25.82 | 25.15 | 5 | 15940 | 37 | 63473040 |
| Open angle glaucoma | 25.43 | 25.15 | 7 | 15938 | 267 | 63472810 |
| Cataract cortical | 25.36 | 25.15 | 5 | 15940 | 41 | 63473036 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Visual acuity reduced | 2836.57 | 30.67 | 739 | 12400 | 15410 | 34928382 |
| Retinal haemorrhage | 1186.43 | 30.67 | 293 | 12846 | 4796 | 34938996 |
| Death | 846.14 | 30.67 | 878 | 12261 | 397171 | 34546621 |
| Macular oedema | 844.07 | 30.67 | 200 | 12939 | 2714 | 34941078 |
| Vitreous haemorrhage | 788.09 | 30.67 | 182 | 12957 | 2191 | 34941601 |
| Endophthalmitis | 634.20 | 30.67 | 165 | 12974 | 3343 | 34940449 |
| Detachment of retinal pigment epithelium | 625.49 | 30.67 | 116 | 13023 | 404 | 34943388 |
| Subretinal fluid | 600.24 | 30.67 | 108 | 13031 | 302 | 34943490 |
| Retinal pigment epithelial tear | 598.82 | 30.67 | 102 | 13037 | 181 | 34943611 |
| Retinal oedema | 550.90 | 30.67 | 108 | 13031 | 540 | 34943252 |
| Vitreous floaters | 540.21 | 30.67 | 146 | 12993 | 3439 | 34940353 |
| Cerebrovascular accident | 407.21 | 30.67 | 300 | 12839 | 84511 | 34859281 |
| Visual impairment | 404.19 | 30.67 | 218 | 12921 | 35584 | 34908208 |
| Choroidal neovascularisation | 369.55 | 30.67 | 66 | 13073 | 174 | 34943618 |
| Eye haemorrhage | 322.66 | 30.67 | 102 | 13037 | 4203 | 34939589 |
| Retinal detachment | 319.88 | 30.67 | 107 | 13032 | 5284 | 34938508 |
| Polypoidal choroidal vasculopathy | 316.86 | 30.67 | 55 | 13084 | 115 | 34943677 |
| Intraocular pressure increased | 312.10 | 30.67 | 105 | 13034 | 5278 | 34938514 |
| Vision blurred | 279.17 | 30.67 | 188 | 12951 | 45775 | 34898017 |
| Blindness | 265.54 | 30.67 | 124 | 13015 | 14862 | 34928930 |
| Eye pain | 259.17 | 30.67 | 118 | 13021 | 13344 | 34930448 |
| Retinal exudates | 240.28 | 30.67 | 56 | 13083 | 700 | 34943092 |
| Cerebral infarction | 233.42 | 30.67 | 139 | 13000 | 27316 | 34916476 |
| Myocardial infarction | 228.17 | 30.67 | 253 | 12886 | 120832 | 34822960 |
| Cystoid macular oedema | 211.66 | 30.67 | 50 | 13089 | 665 | 34943127 |
| Ocular hypertension | 203.42 | 30.67 | 50 | 13089 | 794 | 34942998 |
| Cataract | 192.92 | 30.67 | 121 | 13018 | 26065 | 34917727 |
| Retinal thickening | 190.42 | 30.67 | 29 | 13110 | 11 | 34943781 |
| Metamorphopsia | 177.75 | 30.67 | 41 | 13098 | 488 | 34943304 |
| Vitreous detachment | 166.32 | 30.67 | 43 | 13096 | 845 | 34942947 |
| Macular hole | 159.08 | 30.67 | 32 | 13107 | 186 | 34943606 |
| Blindness transient | 155.45 | 30.67 | 50 | 13089 | 2176 | 34941616 |
| Vitreous opacities | 153.43 | 30.67 | 34 | 13105 | 333 | 34943459 |
| Retinal disorder | 148.05 | 30.67 | 40 | 13099 | 937 | 34942855 |
| Diabetic retinopathy | 144.22 | 30.67 | 45 | 13094 | 1772 | 34942020 |
| Vitritis | 142.19 | 30.67 | 38 | 13101 | 853 | 34942939 |
| Increased insulin requirement | 141.37 | 30.67 | 26 | 13113 | 85 | 34943707 |
| Retinal vein occlusion | 138.23 | 30.67 | 43 | 13096 | 1676 | 34942116 |
| Ocular discomfort | 137.10 | 30.67 | 45 | 13094 | 2089 | 34941703 |
| Macular degeneration | 128.07 | 30.67 | 43 | 13096 | 2143 | 34941649 |
| Disease progression | 121.90 | 30.67 | 175 | 12964 | 107902 | 34835890 |
| Dry age-related macular degeneration | 120.26 | 30.67 | 23 | 13116 | 98 | 34943694 |
| Retinal tear | 118.79 | 30.67 | 33 | 13106 | 860 | 34942932 |
| Vitreous disorder | 118.03 | 30.67 | 22 | 13117 | 79 | 34943713 |
| Cataract nuclear | 115.24 | 30.67 | 29 | 13110 | 509 | 34943283 |
| Suture rupture | 114.99 | 30.67 | 27 | 13112 | 349 | 34943443 |
| Retinal ischaemia | 114.21 | 30.67 | 27 | 13112 | 360 | 34943432 |
| Retinal cyst | 113.29 | 30.67 | 20 | 13119 | 48 | 34943744 |
| Macular fibrosis | 109.75 | 30.67 | 26 | 13113 | 350 | 34943442 |
| Eye disorder | 107.21 | 30.67 | 58 | 13081 | 9470 | 34934322 |
| Glaucoma | 106.51 | 30.67 | 52 | 13087 | 6860 | 34936932 |
| Retinal degeneration | 106.49 | 30.67 | 27 | 13112 | 489 | 34943303 |
| Subretinal fibrosis | 104.62 | 30.67 | 20 | 13119 | 85 | 34943707 |
| Eye inflammation | 100.44 | 30.67 | 36 | 13103 | 2182 | 34941610 |
| Anterior chamber inflammation | 100.07 | 30.67 | 23 | 13116 | 269 | 34943523 |
| Ocular hyperaemia | 99.88 | 30.67 | 59 | 13080 | 11393 | 34932399 |
| Blindness unilateral | 97.51 | 30.67 | 43 | 13096 | 4499 | 34939293 |
| Neovascular age-related macular degeneration | 96.65 | 30.67 | 21 | 13118 | 186 | 34943606 |
| Retinal artery occlusion | 94.51 | 30.67 | 33 | 13106 | 1852 | 34941940 |
| Transient ischaemic attack | 93.95 | 30.67 | 80 | 13059 | 27533 | 34916259 |
| Retinal scar | 92.87 | 30.67 | 22 | 13117 | 296 | 34943496 |
| Macular scar | 90.18 | 30.67 | 15 | 13124 | 21 | 34943771 |
| Diarrhoea | 89.36 | 30.67 | 19 | 13120 | 389893 | 34553899 |
| Haemorrhage | 87.34 | 30.67 | 102 | 13037 | 51268 | 34892524 |
| Retinal neovascularisation | 85.27 | 30.67 | 18 | 13121 | 137 | 34943655 |
| Hypopyon | 83.10 | 30.67 | 21 | 13118 | 375 | 34943417 |
| Age-related macular degeneration | 81.38 | 30.67 | 20 | 13119 | 317 | 34943475 |
| Pyrexia | 80.97 | 30.67 | 14 | 13125 | 332999 | 34610793 |
| Visual field defect | 79.03 | 30.67 | 37 | 13102 | 4446 | 34939346 |
| Disease recurrence | 78.75 | 30.67 | 65 | 13074 | 21425 | 34922367 |
| Serous retinal detachment | 78.58 | 30.67 | 22 | 13117 | 590 | 34943202 |
| Retinal aneurysm | 76.97 | 30.67 | 16 | 13123 | 112 | 34943680 |
| Hyphaema | 74.91 | 30.67 | 21 | 13118 | 566 | 34943226 |
| Macular ischaemia | 72.40 | 30.67 | 14 | 13125 | 64 | 34943728 |
| Diabetic retinal oedema | 70.26 | 30.67 | 16 | 13123 | 179 | 34943613 |
| Neovascularisation | 70.16 | 30.67 | 12 | 13127 | 22 | 34943770 |
| Ocular vascular disorder | 68.52 | 30.67 | 15 | 13124 | 138 | 34943654 |
| Diabetic foot | 68.37 | 30.67 | 29 | 13110 | 2759 | 34941033 |
| Non-infectious endophthalmitis | 67.86 | 30.67 | 15 | 13124 | 145 | 34943647 |
| Retinal depigmentation | 65.53 | 30.67 | 12 | 13127 | 38 | 34943754 |
| Inappropriate schedule of product administration | 64.49 | 30.67 | 97 | 13042 | 62199 | 34881593 |
| Fatigue | 63.71 | 30.67 | 30 | 13109 | 370623 | 34573169 |
| Uveitis | 63.55 | 30.67 | 38 | 13101 | 7497 | 34936295 |
| Corneal oedema | 61.44 | 30.67 | 22 | 13117 | 1329 | 34942463 |
| Toxicity to various agents | 59.76 | 30.67 | 4 | 13135 | 200358 | 34743434 |
| Posterior capsule opacification | 59.54 | 30.67 | 13 | 13126 | 118 | 34943674 |
| No adverse event | 59.40 | 30.67 | 57 | 13082 | 22870 | 34920922 |
| Macular cyst | 58.68 | 30.67 | 9 | 13130 | 4 | 34943788 |
| Cutis laxa | 57.72 | 30.67 | 12 | 13127 | 84 | 34943708 |
| Subretinal haematoma | 56.81 | 30.67 | 9 | 13130 | 7 | 34943785 |
| Foreign body sensation in eyes | 55.80 | 30.67 | 17 | 13122 | 617 | 34943175 |
| Eye oedema | 55.28 | 30.67 | 18 | 13121 | 814 | 34942978 |
| Anterior chamber cell | 55.16 | 30.67 | 15 | 13124 | 360 | 34943432 |
| Retinal vascular disorder | 54.80 | 30.67 | 13 | 13126 | 176 | 34943616 |
| Aphonia | 53.83 | 30.67 | 26 | 13113 | 3347 | 34940445 |
| Photopsia | 53.39 | 30.67 | 22 | 13117 | 1946 | 34941846 |
| Retinal vasculitis | 53.27 | 30.67 | 15 | 13124 | 411 | 34943381 |
| Nausea | 50.43 | 30.67 | 33 | 13106 | 339875 | 34603917 |
| Maculopathy | 49.11 | 30.67 | 17 | 13122 | 929 | 34942863 |
| Acute kidney injury | 48.89 | 30.67 | 27 | 13112 | 304961 | 34638831 |
| Hypotension | 48.25 | 30.67 | 12 | 13127 | 221637 | 34722155 |
| Cataract traumatic | 48.21 | 30.67 | 7 | 13132 | 0 | 34943792 |
| Retinopathy proliferative | 47.27 | 30.67 | 10 | 13129 | 77 | 34943715 |
| Vitreous haze | 46.75 | 30.67 | 9 | 13130 | 40 | 34943752 |
| Corneal erosion | 46.08 | 30.67 | 10 | 13129 | 88 | 34943704 |
| Drug interaction | 45.88 | 30.67 | 14 | 13125 | 225932 | 34717860 |
| Poor peripheral circulation | 44.84 | 30.67 | 18 | 13121 | 1489 | 34942303 |
| Lacrimation increased | 42.73 | 30.67 | 31 | 13108 | 8451 | 34935341 |
| Eye irritation | 41.23 | 30.67 | 29 | 13110 | 7532 | 34936260 |
| Keratic precipitates | 41.20 | 30.67 | 10 | 13129 | 150 | 34943642 |
| Conjunctival haemorrhage | 41.20 | 30.67 | 21 | 13118 | 3034 | 34940758 |
| Visual acuity reduced transiently | 39.91 | 30.67 | 9 | 13130 | 96 | 34943696 |
| Hypotony of eye | 39.33 | 30.67 | 9 | 13130 | 103 | 34943689 |
| Pseudoendophthalmitis | 39.27 | 30.67 | 8 | 13131 | 50 | 34943742 |
| Ischaemic stroke | 39.21 | 30.67 | 41 | 13098 | 18209 | 34925583 |
| Myocardial ischaemia | 39.01 | 30.67 | 40 | 13099 | 17368 | 34926424 |
| Decreased appetite | 38.20 | 30.67 | 8 | 13131 | 166384 | 34777408 |
| Vitrectomy | 37.27 | 30.67 | 9 | 13130 | 132 | 34943660 |
| Thrombocytopenia | 36.94 | 30.67 | 7 | 13132 | 156240 | 34787552 |
| Device issue | 36.69 | 30.67 | 30 | 13109 | 9747 | 34934045 |
| Conjunctival bleb | 36.57 | 30.67 | 7 | 13132 | 30 | 34943762 |
| Ophthalmological examination abnormal | 35.85 | 30.67 | 7 | 13132 | 34 | 34943758 |
| Anaemia | 35.44 | 30.67 | 22 | 13117 | 233313 | 34710479 |
| Retinoschisis | 34.73 | 30.67 | 6 | 13133 | 12 | 34943780 |
| Corneal disorder | 34.31 | 30.67 | 13 | 13126 | 921 | 34942871 |
| Vitreous adhesions | 34.10 | 30.67 | 6 | 13133 | 14 | 34943778 |
| Visual acuity tests abnormal | 33.93 | 30.67 | 7 | 13132 | 47 | 34943745 |
| Conjunctival hyperaemia | 33.82 | 30.67 | 17 | 13122 | 2385 | 34941407 |
| Vomiting | 32.83 | 30.67 | 27 | 13112 | 247594 | 34696198 |
| Cataract subcapsular | 31.98 | 30.67 | 10 | 13129 | 396 | 34943396 |
| Tachyphylaxis | 31.86 | 30.67 | 8 | 13131 | 139 | 34943653 |
| Rash | 31.15 | 30.67 | 23 | 13116 | 222729 | 34721063 |
| Corneal abrasion | 30.71 | 30.67 | 9 | 13130 | 285 | 34943507 |
| Choroidal haemorrhage | 30.68 | 30.67 | 7 | 13132 | 79 | 34943713 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Visual acuity reduced | 4216.26 | 23.80 | 1053 | 18724 | 28416 | 79696195 |
| Endophthalmitis | 1407.43 | 23.80 | 325 | 19452 | 6103 | 79718508 |
| Retinal haemorrhage | 1373.99 | 23.80 | 334 | 19443 | 7883 | 79716728 |
| Macular oedema | 1051.64 | 23.80 | 249 | 19528 | 5225 | 79719386 |
| Detachment of retinal pigment epithelium | 955.42 | 23.80 | 167 | 19610 | 649 | 79723962 |
| Vitreous haemorrhage | 921.37 | 23.80 | 208 | 19569 | 3505 | 79721106 |
| Retinal pigment epithelial tear | 887.09 | 23.80 | 145 | 19632 | 331 | 79724280 |
| Death | 859.34 | 23.80 | 864 | 18913 | 565650 | 79158961 |
| Subretinal fluid | 845.71 | 23.80 | 151 | 19626 | 681 | 79723930 |
| Retinal oedema | 752.76 | 23.80 | 140 | 19637 | 825 | 79723786 |
| Choroidal neovascularisation | 691.12 | 23.80 | 117 | 19660 | 357 | 79724254 |
| Vitreous floaters | 651.58 | 23.80 | 180 | 19597 | 7076 | 79717535 |
| Eye haemorrhage | 581.66 | 23.80 | 176 | 19601 | 9581 | 79715030 |
| Cerebrovascular accident | 566.27 | 23.80 | 395 | 19382 | 154897 | 79569714 |
| Polypoidal choroidal vasculopathy | 519.22 | 23.80 | 83 | 19694 | 154 | 79724457 |
| Eye pain | 514.71 | 23.80 | 229 | 19548 | 37349 | 79687262 |
| Visual impairment | 489.51 | 23.80 | 297 | 19480 | 91834 | 79632777 |
| Age-related macular degeneration | 455.16 | 23.80 | 92 | 19685 | 882 | 79723729 |
| Retinal detachment | 426.08 | 23.80 | 137 | 19640 | 9110 | 79715501 |
| Intraocular pressure increased | 414.42 | 23.80 | 134 | 19643 | 9071 | 79715540 |
| Blindness | 356.85 | 23.80 | 163 | 19614 | 28220 | 79696391 |
| Retinal thickening | 354.20 | 23.80 | 51 | 19726 | 22 | 79724589 |
| Macular hole | 350.85 | 23.80 | 72 | 19705 | 749 | 79723862 |
| Cerebral infarction | 343.82 | 23.80 | 185 | 19592 | 45491 | 79679120 |
| Retinal exudates | 338.00 | 23.80 | 75 | 19702 | 1160 | 79723451 |
| Vision blurred | 318.42 | 23.80 | 240 | 19537 | 105658 | 79618953 |
| Photopsia | 312.55 | 23.80 | 95 | 19682 | 5241 | 79719370 |
| Metamorphopsia | 254.31 | 23.80 | 60 | 19717 | 1233 | 79723378 |
| Myocardial infarction | 247.86 | 23.80 | 265 | 19512 | 183864 | 79540747 |
| Cataract | 237.47 | 23.80 | 163 | 19614 | 61957 | 79662654 |
| Vitritis | 229.89 | 23.80 | 59 | 19718 | 1735 | 79722876 |
| Cystoid macular oedema | 228.91 | 23.80 | 60 | 19717 | 1920 | 79722691 |
| Macular fibrosis | 226.15 | 23.80 | 49 | 19728 | 674 | 79723937 |
| Transient ischaemic attack | 224.73 | 23.80 | 148 | 19629 | 52547 | 79672064 |
| Ocular hypertension | 224.51 | 23.80 | 56 | 19721 | 1464 | 79723147 |
| Macular degeneration | 218.34 | 23.80 | 88 | 19689 | 11208 | 79713403 |
| Disease progression | 216.39 | 23.80 | 247 | 19530 | 184115 | 79540496 |
| Retinal vein occlusion | 215.47 | 23.80 | 64 | 19713 | 3259 | 79721352 |
| Eye inflammation | 211.89 | 23.80 | 74 | 19703 | 6339 | 79718272 |
| Vitreous detachment | 207.12 | 23.80 | 57 | 19720 | 2202 | 79722409 |
| Retinal ischaemia | 200.01 | 23.80 | 45 | 19732 | 743 | 79723868 |
| Retinal disorder | 198.59 | 23.80 | 54 | 19723 | 1993 | 79722618 |
| Subretinal fibrosis | 195.26 | 23.80 | 34 | 19743 | 128 | 79724483 |
| Retinal tear | 187.39 | 23.80 | 49 | 19728 | 1553 | 79723058 |
| Diabetic retinopathy | 184.88 | 23.80 | 56 | 19721 | 3050 | 79721561 |
| Non-infectious endophthalmitis | 183.12 | 23.80 | 36 | 19741 | 295 | 79724316 |
| Retinal artery occlusion | 181.64 | 23.80 | 56 | 19721 | 3238 | 79721373 |
| Retinal degeneration | 178.79 | 23.80 | 45 | 19732 | 1221 | 79723390 |
| Retinal neovascularisation | 178.11 | 23.80 | 32 | 19745 | 150 | 79724461 |
| Retinal depigmentation | 177.69 | 23.80 | 35 | 19742 | 290 | 79724321 |
| Retinal cyst | 177.28 | 23.80 | 30 | 19747 | 91 | 79724520 |
| Vitreous opacities | 173.79 | 23.80 | 39 | 19738 | 636 | 79723975 |
| Dry throat | 173.34 | 23.80 | 67 | 19710 | 7639 | 79716972 |
| Ocular hyperaemia | 173.21 | 23.80 | 100 | 19677 | 28106 | 79696505 |
| Vitreous disorder | 172.82 | 23.80 | 33 | 19744 | 228 | 79724383 |
| Ocular discomfort | 166.54 | 23.80 | 58 | 19719 | 4925 | 79719686 |
| Dry age-related macular degeneration | 156.62 | 23.80 | 31 | 19746 | 264 | 79724347 |
| Blindness transient | 153.52 | 23.80 | 54 | 19723 | 4722 | 79719889 |
| Retinal scar | 150.81 | 23.80 | 32 | 19745 | 396 | 79724215 |
| Blindness unilateral | 148.98 | 23.80 | 61 | 19716 | 8085 | 79716526 |
| Anterior chamber cell | 140.34 | 23.80 | 35 | 19742 | 914 | 79723697 |
| Increased insulin requirement | 138.62 | 23.80 | 26 | 19751 | 161 | 79724450 |
| Eye discharge | 137.63 | 23.80 | 53 | 19724 | 5981 | 79718630 |
| Uveitis | 137.33 | 23.80 | 72 | 19705 | 16758 | 79707853 |
| Cataract nuclear | 136.95 | 23.80 | 35 | 19742 | 1011 | 79723600 |
| Visual field defect | 129.72 | 23.80 | 57 | 19720 | 8988 | 79715623 |
| Neovascular age-related macular degeneration | 124.22 | 23.80 | 27 | 19750 | 377 | 79724234 |
| Eye pruritus | 123.81 | 23.80 | 72 | 19705 | 20498 | 79704113 |
| Anterior chamber inflammation | 120.05 | 23.80 | 28 | 19749 | 546 | 79724065 |
| Pharyngeal oedema | 119.78 | 23.80 | 65 | 19712 | 16207 | 79708404 |
| Retinal vascular disorder | 118.14 | 23.80 | 25 | 19752 | 305 | 79724306 |
| Suture rupture | 113.46 | 23.80 | 27 | 19750 | 576 | 79724035 |
| Glaucoma | 113.22 | 23.80 | 67 | 19710 | 19694 | 79704917 |
| Macular scar | 112.72 | 23.80 | 20 | 19757 | 86 | 79724525 |
| Eye disorder | 107.69 | 23.80 | 69 | 19708 | 23343 | 79701268 |
| Diarrhoea | 104.65 | 23.80 | 44 | 19733 | 880445 | 78844166 |
| Hypopyon | 100.93 | 23.80 | 28 | 19749 | 1114 | 79723497 |
| Retinal aneurysm | 99.18 | 23.80 | 21 | 19756 | 257 | 79724354 |
| Haemorrhage | 96.57 | 23.80 | 116 | 19661 | 91002 | 79633609 |
| Iridocyclitis | 93.36 | 23.80 | 35 | 19742 | 3669 | 79720942 |
| Choroidal haemorrhage | 90.55 | 23.80 | 18 | 19759 | 157 | 79724454 |
| Serous retinal detachment | 89.77 | 23.80 | 25 | 19752 | 1009 | 79723602 |
| Toxicity to various agents | 87.75 | 23.80 | 4 | 19773 | 421536 | 79303075 |
| Macular ischaemia | 86.46 | 23.80 | 16 | 19761 | 91 | 79724520 |
| Eye oedema | 84.60 | 23.80 | 28 | 19749 | 2035 | 79722576 |
| Pyrexia | 83.67 | 23.80 | 32 | 19745 | 678677 | 79045934 |
| No adverse event | 83.22 | 23.80 | 71 | 19706 | 37121 | 79687490 |
| Throat tightness | 83.14 | 23.80 | 63 | 19714 | 27844 | 79696767 |
| Retinopathy proliferative | 82.99 | 23.80 | 16 | 19761 | 117 | 79724494 |
| Fatigue | 80.22 | 23.80 | 68 | 19709 | 929659 | 78794952 |
| Diabetic foot | 79.62 | 23.80 | 31 | 19746 | 3601 | 79721010 |
| Hyphaema | 79.13 | 23.80 | 22 | 19755 | 882 | 79723729 |
| Retinal vasculitis | 78.83 | 23.80 | 24 | 19753 | 1329 | 79723282 |
| Ischaemic stroke | 77.73 | 23.80 | 65 | 19712 | 33066 | 79691545 |
| Macular cyst | 76.68 | 23.80 | 13 | 19764 | 40 | 79724571 |
| Disease recurrence | 74.70 | 23.80 | 72 | 19705 | 44037 | 79680574 |
| Corneal oedema | 74.30 | 23.80 | 27 | 19750 | 2593 | 79722018 |
| Retinoschisis | 72.05 | 23.80 | 12 | 19765 | 32 | 79724579 |
| Foreign body sensation in eyes | 71.66 | 23.80 | 25 | 19752 | 2132 | 79722479 |
| Posterior capsule opacification | 71.03 | 23.80 | 15 | 19762 | 181 | 79724430 |
| Conjunctival bleb | 69.10 | 23.80 | 13 | 19764 | 82 | 79724529 |
| Eye irritation | 69.04 | 23.80 | 50 | 19727 | 20631 | 79703980 |
| Device issue | 67.38 | 23.80 | 55 | 19722 | 27053 | 79697558 |
| Visual acuity tests abnormal | 65.85 | 23.80 | 13 | 19764 | 109 | 79724502 |
| Subretinal haematoma | 65.61 | 23.80 | 10 | 19767 | 11 | 79724600 |
| Drug interaction | 65.38 | 23.80 | 12 | 19765 | 415171 | 79309440 |
| Lacrimation increased | 65.32 | 23.80 | 50 | 19727 | 22427 | 79702184 |
| Conjunctival haemorrhage | 65.32 | 23.80 | 31 | 19746 | 5834 | 79718777 |
| Rash | 65.27 | 23.80 | 31 | 19746 | 578327 | 79146284 |
| Cutis laxa | 63.00 | 23.80 | 13 | 19764 | 139 | 79724472 |
| Keratic precipitates | 61.83 | 23.80 | 15 | 19762 | 348 | 79724263 |
| Nausea | 59.68 | 23.80 | 91 | 19686 | 957105 | 78767506 |
| Tachyphylaxis | 58.03 | 23.80 | 14 | 19763 | 317 | 79724294 |
| Maculopathy | 58.01 | 23.80 | 23 | 19754 | 2802 | 79721809 |
| Exudative retinopathy | 57.28 | 23.80 | 9 | 19768 | 14 | 79724597 |
| Inappropriate schedule of product administration | 56.47 | 23.80 | 111 | 19666 | 133517 | 79591094 |
| Vomiting | 54.54 | 23.80 | 51 | 19726 | 665777 | 79058834 |
| Ophthalmological examination abnormal | 53.58 | 23.80 | 10 | 19767 | 60 | 79724551 |
| Joint swelling | 53.39 | 23.80 | 5 | 19772 | 288641 | 79435970 |
| Hypotony of eye | 50.88 | 23.80 | 12 | 19765 | 246 | 79724365 |
| Vitreous adhesions | 50.48 | 23.80 | 9 | 19768 | 40 | 79724571 |
| Abdominal pain | 50.24 | 23.80 | 17 | 19760 | 389552 | 79335059 |
| Vitreous haze | 49.16 | 23.80 | 10 | 19767 | 99 | 79724512 |
| Hypotension | 49.02 | 23.80 | 24 | 19753 | 440293 | 79284318 |
| Weight increased | 48.26 | 23.80 | 6 | 19771 | 277380 | 79447231 |
| Ocular vascular disorder | 47.01 | 23.80 | 13 | 19764 | 511 | 79724100 |
| Vitreous degeneration | 46.85 | 23.80 | 8 | 19769 | 26 | 79724585 |
| Decreased appetite | 45.81 | 23.80 | 14 | 19763 | 342404 | 79382207 |
| Staphylococcus test positive | 45.23 | 23.80 | 25 | 19752 | 6456 | 79718155 |
| Anterior chamber flare | 45.03 | 23.80 | 10 | 19767 | 155 | 79724456 |
| Visual acuity reduced transiently | 44.95 | 23.80 | 11 | 19766 | 265 | 79724346 |
| Aphonia | 44.00 | 23.80 | 29 | 19748 | 10283 | 79714328 |
| Retinal pallor | 43.82 | 23.80 | 6 | 19771 | 0 | 79724611 |
| Retinal pigment epitheliopathy | 43.63 | 23.80 | 12 | 19765 | 462 | 79724149 |
| Cataract subcapsular | 43.27 | 23.80 | 14 | 19763 | 947 | 79723664 |
| Pseudoendophthalmitis | 43.01 | 23.80 | 8 | 19769 | 47 | 79724564 |
| Drug intolerance | 42.94 | 23.80 | 7 | 19770 | 264112 | 79460499 |
| Alopecia | 42.80 | 23.80 | 4 | 19773 | 231351 | 79493260 |
| Pain | 40.87 | 23.80 | 70 | 19707 | 703732 | 79020879 |
| Iris neovascularisation | 40.75 | 23.80 | 8 | 19769 | 65 | 79724546 |
| Rheumatoid arthritis | 40.22 | 23.80 | 3 | 19774 | 208467 | 79516144 |
| Retinal injury | 38.73 | 23.80 | 10 | 19767 | 301 | 79724310 |
| Macular pigmentation | 38.32 | 23.80 | 6 | 19771 | 9 | 79724602 |
| Angina pectoris | 37.93 | 23.80 | 55 | 19722 | 51677 | 79672934 |
| Acute kidney injury | 37.73 | 23.80 | 44 | 19733 | 519360 | 79205251 |
| Posterior capsule rupture | 37.57 | 23.80 | 6 | 19771 | 11 | 79724600 |
| Diabetic retinal oedema | 37.31 | 23.80 | 10 | 19767 | 349 | 79724262 |
| Drug resistance | 37.13 | 23.80 | 49 | 19728 | 42164 | 79682447 |
| Retinal fibrosis | 36.90 | 23.80 | 6 | 19771 | 13 | 79724598 |
| Arthralgia | 36.85 | 23.80 | 53 | 19724 | 571750 | 79152861 |
| Macular detachment | 36.73 | 23.80 | 9 | 19768 | 218 | 79724393 |
| Retinal vascular occlusion | 36.36 | 23.80 | 11 | 19766 | 596 | 79724015 |
| Conjunctival retraction | 36.02 | 23.80 | 6 | 19771 | 16 | 79724595 |
| Dyspnoea | 35.97 | 23.80 | 102 | 19675 | 856923 | 78867688 |
| Iritis | 35.80 | 23.80 | 18 | 19759 | 3837 | 79720774 |
| Optical coherence tomography abnormal | 35.76 | 23.80 | 6 | 19771 | 17 | 79724594 |
| Eye infection | 35.69 | 23.80 | 27 | 19750 | 11893 | 79712718 |
| Dysphonia | 35.37 | 23.80 | 56 | 19721 | 56816 | 79667795 |
| Haemorrhagic stroke | 35.26 | 23.80 | 26 | 19751 | 11020 | 79713591 |
| Pruritus | 34.96 | 23.80 | 28 | 19749 | 394620 | 79329991 |
| Foreign body in eye | 34.88 | 23.80 | 9 | 19768 | 270 | 79724341 |
| Anaemia | 34.18 | 23.80 | 36 | 19741 | 444979 | 79279632 |
| Blepharitis | 33.23 | 23.80 | 16 | 19761 | 3108 | 79721503 |
| Retinal drusen | 33.07 | 23.80 | 6 | 19771 | 30 | 79724581 |
| Conjunctival erosion | 33 | 23.80 | 8 | 19769 | 185 | 79724426 |
| Suspected transmission of an infectious agent via product | 32.80 | 23.80 | 12 | 19765 | 1174 | 79723437 |
| Neovascularisation | 32.23 | 23.80 | 12 | 19765 | 1233 | 79723378 |
| Abdominal discomfort | 32.19 | 23.80 | 11 | 19766 | 250716 | 79473895 |
| Pain in extremity | 32.11 | 23.80 | 26 | 19751 | 364512 | 79360099 |
| Corneal disorder | 31.43 | 23.80 | 14 | 19763 | 2277 | 79722334 |
| Choroidal effusion | 31.04 | 23.80 | 10 | 19767 | 667 | 79723944 |
| Detachment of macular retinal pigment epithelium | 30.70 | 23.80 | 5 | 19772 | 11 | 79724600 |
| Open angle glaucoma | 30.68 | 23.80 | 9 | 19768 | 438 | 79724173 |
| Weight decreased | 30.46 | 23.80 | 26 | 19751 | 355172 | 79369439 |
| Thrombocytopenia | 30.19 | 23.80 | 14 | 19763 | 265245 | 79459366 |
| Acute myocardial infarction | 30.14 | 23.80 | 62 | 19715 | 76974 | 79647637 |
| Charles Bonnet syndrome | 30.11 | 23.80 | 5 | 19772 | 13 | 79724598 |
| Somnolence | 29.80 | 23.80 | 11 | 19766 | 238970 | 79485641 |
| Fundoscopy abnormal | 29.53 | 23.80 | 6 | 19771 | 59 | 79724552 |
| Eye injury | 29.52 | 23.80 | 14 | 19763 | 2629 | 79721982 |
| Concomitant disease aggravated | 29.16 | 23.80 | 25 | 19752 | 13142 | 79711469 |
| Giant cell arteritis | 28.99 | 23.80 | 14 | 19763 | 2737 | 79721874 |
| Conjunctival disorder | 28.48 | 23.80 | 8 | 19769 | 333 | 79724278 |
| COVID-19 | 28.43 | 23.80 | 3 | 19774 | 157671 | 79566940 |
| Aneurysm | 28.43 | 23.80 | 15 | 19762 | 3533 | 79721078 |
| Dry eye | 28.15 | 23.80 | 40 | 19737 | 36891 | 79687720 |
| Chorioretinal scar | 27.86 | 23.80 | 6 | 19771 | 80 | 79724531 |
| Myocardial ischaemia | 27.84 | 23.80 | 33 | 19744 | 25486 | 79699125 |
| Pancytopenia | 27.82 | 23.80 | 4 | 19773 | 165741 | 79558870 |
| Constipation | 27.77 | 23.80 | 18 | 19759 | 283032 | 79441579 |
| IIIrd nerve paresis | 27.77 | 23.80 | 7 | 19770 | 191 | 79724420 |
| Choroidal detachment | 27.56 | 23.80 | 9 | 19768 | 627 | 79723984 |
| Abnormal sensation in eye | 27.11 | 23.80 | 12 | 19765 | 1923 | 79722688 |
| Intraocular lens implant | 26.78 | 23.80 | 8 | 19769 | 415 | 79724196 |
| Vitrectomy | 26.64 | 23.80 | 7 | 19770 | 226 | 79724385 |
| Stomatitis | 25.94 | 23.80 | 3 | 19774 | 146754 | 79577857 |
| Oedema peripheral | 24.81 | 23.80 | 16 | 19761 | 252272 | 79472339 |
| Sudden visual loss | 24.72 | 23.80 | 5 | 19772 | 48 | 79724563 |
| White blood cell count decreased | 24.62 | 23.80 | 8 | 19769 | 188280 | 79536331 |
| Asthenopia | 24.52 | 23.80 | 12 | 19765 | 2415 | 79722196 |
| Arthropathy | 24.10 | 23.80 | 7 | 19770 | 177104 | 79547507 |
| Aspartate aminotransferase increased | 24.09 | 23.80 | 3 | 19774 | 138638 | 79585973 |
| Anterior chamber disorder | 24.08 | 23.80 | 6 | 19771 | 156 | 79724455 |
| Peripheral swelling | 24.02 | 23.80 | 19 | 19758 | 269598 | 79455013 |
None
| Source | Code | Description |
|---|---|---|
| ATC | S01LA04 | SENSORY ORGANS OPHTHALMOLOGICALS OCULAR VASCULAR DISORDER AGENTS Antineovascularisation agents |
| MeSH PA | D020533 | Angiogenesis Inhibitors |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D006131 | Growth Inhibitors |
| MeSH PA | D006133 | Growth Substances |
| FDA MoA | N0000193542 | Vascular Endothelial Growth Factor Inhibitors |
| FDA EPC | N0000193543 | Vascular Endothelial Growth Factor Inhibitor |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diabetic retinopathy | indication | 4855003 | DOID:8947 |
| Choroidal retinal neovascularization | indication | 75971007 | |
| Central retinal vein occlusion with macular edema | indication | 232039004 | |
| Branch retinal vein occlusion with macular edema | indication | 232048009 | |
| Age related macular degeneration | indication | 267718000 | DOID:10871 |
| Macular edema due to diabetes mellitus | indication | 312912001 | DOID:9191 |
| Exudative age-related macular degeneration | indication | 414173003 | DOID:10873 |
| Retinopathy of prematurity | indication | 415297005 | DOID:13025 |
| Eye infection | contraindication | 128351009 |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor A | Secreted | ANTIBODY BINDING | DRUG LABEL | DRUG LABEL |
| ID | Source |
|---|---|
| D05697 | KEGG_DRUG |
| 4025260 | VUID |
| N0000179788 | NUI |
| 4025260 | VANDF |
| 4041511 | VANDF |
| CHEMBL1201825 | ChEMBL_ID |
| C000719192 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6779 | IUPHAR_LIGAND_ID |
| DB01270 | DRUGBANK_ID |
| 2602351 | RXNORM |
| 21678 | MMSL |
| 350639 | MMSL |
| 39922 | MMSL |
| 83454 | MMSL |
| 011622 | NDDF |
| 018852 | NDDF |
| 422456007 | SNOMEDCT_US |
| 425256004 | SNOMEDCT_US |
| D000069579 | MESH_DESCRIPTOR_UI |
| C1566537 | UMLSCUI |
| 8313 | INN_ID |
| ZL1R02VT79 | UNII |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Susvimo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-078 | INJECTION, SOLUTION | 100 mg | INTRAVITREAL | BLA | 30 sections |
| Susvimo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-078 | INJECTION, SOLUTION | 100 mg | INTRAVITREAL | BLA | 30 sections |
| Susvimo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-078 | INJECTION, SOLUTION | 100 mg | INTRAVITREAL | BLA | 30 sections |
| LUCENTIS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-080 | INJECTION, SOLUTION | 10 mg | INTRAVITREAL | BLA | 28 sections |
| LUCENTIS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-080 | INJECTION, SOLUTION | 10 mg | INTRAVITREAL | BLA | 28 sections |
| LUCENTIS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-082 | INJECTION, SOLUTION | 6 mg | INTRAVITREAL | BLA | 28 sections |
| LUCENTIS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-082 | INJECTION, SOLUTION | 6 mg | INTRAVITREAL | BLA | 28 sections |
| Byooviz nuna | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-019 | INJECTION, SOLUTION | 10 mg | INTRAVITREAL | BLA | 30 sections |
| Byooviz nuna | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-019 | INJECTION, SOLUTION | 10 mg | INTRAVITREAL | BLA | 30 sections |
| Byooviz nuna | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-019 | INJECTION, SOLUTION | 10 mg | INTRAVITREAL | BLA | 30 sections |
| CIMERLI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70114-440 | INJECTION, SOLUTION | 0.30 mg | INTRAVITREAL | BLA | 30 sections |
| CIMERLI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70114-440 | INJECTION, SOLUTION | 0.30 mg | INTRAVITREAL | BLA | 30 sections |
| CIMERLI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70114-441 | INJECTION, SOLUTION | 0.50 mg | INTRAVITREAL | BLA | 30 sections |
| CIMERLI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70114-441 | INJECTION, SOLUTION | 0.50 mg | INTRAVITREAL | BLA | 30 sections |