All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

ranibizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
humanized origin	4971	347396-82-1

Description:

Molecule	Description
Synonyms: ranibizumab-nuna byooviz ranibizumab lucentis ranibizimumab ranibizumab (genetical recombination)	A recombinant humanized monoclonal antibody fragment that binds VEGF-A to prevent its binding to VEGFR-1 and VEGFR-2 receptors. This activity reduces vessel permeability and angiogenesis in the treatment of neovascular age-related MACULAR DEGENERATION. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 21, 2009	PMDA	Novartis Pharma
June 30, 2006	FDA	GENENTECH
Jan. 22, 2007	EMA	Novartis Europharm Limited

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Visual acuity reduced	2747.16	24.79	716	15190	20010	56256151
Endophthalmitis	1196.89	24.79	256	15650	2887	56273274
Death	1156.79	24.79	869	15037	340557	55935604
Retinal haemorrhage	856.42	24.79	210	15696	4481	56271680
Age-related macular degeneration	818.52	24.79	149	15757	654	56275507
Cerebrovascular accident	757.77	24.79	423	15483	98847	56177314
Macular oedema	744.29	24.79	180	15726	3614	56272547
Retinal pigment epithelial tear	698.15	24.79	110	15796	142	56276019
Detachment of retinal pigment epithelium	688.11	24.79	115	15791	264	56275897
Blindness	644.34	24.79	229	15677	18192	56257969
Eye haemorrhage	575.18	24.79	171	15735	7676	56268485
Vitreous floaters	568.05	24.79	157	15749	5410	56270751
Retinal oedema	541.07	24.79	101	15805	522	56275639
Visual impairment	487.16	24.79	287	15619	73915	56202246
Vitreous haemorrhage	476.04	24.79	110	15796	1796	56274365
Eye pain	474.60	24.79	212	15694	30635	56245526
Choroidal neovascularisation	458.04	24.79	80	15826	261	56275900
Diabetic retinal oedema	434.65	24.79	80	15826	377	56275784
Subretinal fluid	393.71	24.79	72	15834	325	56275836
Metamorphopsia	355.80	24.79	77	15829	916	56275245
Photopsia	338.29	24.79	98	15808	4005	56272156
Polypoidal choroidal vasculopathy	300.29	24.79	47	15859	56	56276105
Eye discharge	290.13	24.79	93	15813	5360	56270801
Eye pruritus	275.24	24.79	115	15791	14091	56262070
Vision blurred	270.63	24.79	208	15698	82735	56193426
Neovascular age-related macular degeneration	262.16	24.79	47	15859	185	56275976
Intraocular pressure increased	255.86	24.79	86	15820	5755	56270406
Cystoid macular oedema	245.99	24.79	62	15844	1479	56274682
Retinal vein occlusion	229.71	24.79	62	15844	1946	56274215
Retinal exudates	220.89	24.79	49	15857	658	56275503
Retinal detachment	218.26	24.79	75	15831	5366	56270795
Transient ischaemic attack	217.61	24.79	129	15777	33448	56242713
Retinal thickening	214.46	24.79	31	15875	9	56276152
Retinopathy of prematurity	208.43	24.79	42	15864	342	56275819
Macular hole	200.44	24.79	46	15860	726	56275435
Myocardial infarction	199.43	24.79	183	15723	92687	56183474
Macular degeneration	195.64	24.79	99	15807	18809	56257352
Eye irritation	195.05	24.79	99	15807	18929	56257232
Vitritis	191.48	24.79	46	15860	893	56275268
Eye inflammation	188.66	24.79	65	15841	4686	56271475
Vitreous detachment	172.92	24.79	49	15857	1846	56274315
Macular fibrosis	167.05	24.79	35	15871	352	56275809
Dry throat	165.82	24.79	63	15843	6011	56270150
Subretinal fibrosis	163.04	24.79	27	15879	57	56276104
Non-infectious endophthalmitis	160.39	24.79	29	15877	121	56276040
Retinal scar	153.88	24.79	28	15878	122	56276039
Retinal depigmentation	153.55	24.79	31	15875	255	56275906
Blindness unilateral	152.98	24.79	58	15848	5502	56270659
Ocular hyperaemia	151.72	24.79	88	15818	21891	56254270
Retinal disorder	144.67	24.79	41	15865	1545	56274616
Cataract nuclear	137.81	24.79	35	15871	861	56275300
Retinal neovascularisation	134.63	24.79	21	15885	24	56276137
Cerebral infarction	129.10	24.79	80	15826	22425	56253736
Pharyngeal oedema	127.09	24.79	66	15840	13219	56262942
Retinal cyst	124.19	24.79	21	15885	53	56276108
Cataract	121.75	24.79	107	15799	51140	56225021
Retinal degeneration	120.05	24.79	31	15875	816	56275345
Anterior chamber cell	119.12	24.79	28	15878	493	56275668
Vitreous opacities	118.46	24.79	25	15881	261	56275900
Uveitis	114.46	24.79	58	15848	11037	56265124
Iridocyclitis	109.69	24.79	36	15870	2233	56273928
Ocular hypertension	108.61	24.79	29	15877	872	56275289
Retinal artery occlusion	106.04	24.79	32	15874	1506	56274655
Retinal ischaemia	102.98	24.79	23	15883	319	56275842
Macular scar	101.77	24.79	19	15887	98	56276063
Visual field defect	100.41	24.79	44	15862	6045	56270116
Retinal tear	92.71	24.79	27	15879	1122	56275039
Vitreous disorder	91.83	24.79	17	15889	83	56276078
Rheumatoid arthritis	88.08	24.79	5	15901	382599	55893562
Fatigue	81.04	24.79	63	15843	788489	55487672
Diarrhoea	80.79	24.79	40	15866	638467	55637694
Retinal vascular disorder	80.25	24.79	17	15889	181	56275980
Throat tightness	79.11	24.79	59	15847	22348	56253813
Dry age-related macular degeneration	77.56	24.79	16	15890	148	56276013
Retinal aneurysm	73.55	24.79	16	15890	195	56275966
Disease progression	73.30	24.79	117	15789	105056	56171105
Macular pigmentation	70.78	24.79	11	15895	12	56276149
Rash	68.41	24.79	27	15879	493020	55783141
Foreign body sensation in eyes	67.43	24.79	24	15882	1903	56274258
Lacrimation increased	66.31	24.79	49	15857	18299	56257862
Cutis laxa	66.26	24.79	14	15892	147	56276014
Alopecia	64.07	24.79	5	15901	293453	55982708
Foreign body in eye	62.66	24.79	13	15893	124	56276037
Glaucoma	62.00	24.79	46	15860	17283	56258878
Diabetic retinopathy	60.20	24.79	23	15883	2226	56273935
Eye oedema	58.12	24.79	20	15886	1435	56274726
Eye infection	57.67	24.79	36	15870	10208	56265953
Ophthalmological examination abnormal	57.37	24.79	11	15895	67	56276094
Ischaemic stroke	56.46	24.79	43	15863	16799	56259362
Ocular discomfort	55.07	24.79	25	15881	3730	56272431
Maculopathy	55.05	24.79	21	15885	2023	56274138
Choroidal haemorrhage	54.51	24.79	10	15896	46	56276115
Hypopyon	54.29	24.79	16	15890	693	56275468
Posterior capsule opacification	54.10	24.79	11	15895	94	56276067
Pain	52.98	24.79	66	15840	663118	55613043
Blepharitis	51.95	24.79	21	15885	2359	56273802
Drug intolerance	51.39	24.79	7	15899	264811	56011350
Joint swelling	51.02	24.79	10	15896	289790	55986371
Eye disorder	49.12	24.79	43	15863	20409	56255752
Retinal fibrosis	47.71	24.79	7	15899	3	56276158
Exudative retinopathy	47.04	24.79	7	15899	4	56276157
Pyrexia	46.05	24.79	31	15875	418742	55857419
Anterior chamber flare	45.13	24.79	9	15897	69	56276092
Suspected transmission of an infectious agent via product	44.30	24.79	11	15895	246	56275915
Retinoschisis	43.60	24.79	7	15899	11	56276150
Tachyphylaxis	43.52	24.79	11	15895	265	56275896
Conjunctival haemorrhage	42.65	24.79	20	15886	3213	56272948
Anterior chamber inflammation	42.11	24.79	11	15895	303	56275858
Arthralgia	42.05	24.79	48	15858	501621	55774540
Disease recurrence	41.61	24.79	42	15864	23818	56252343
Retinopathy proliferative	41.41	24.79	8	15898	51	56276110
Vitreous adhesions	40.76	24.79	7	15899	20	56276141
Visual acuity tests abnormal	39.93	24.79	8	15898	63	56276098
Conjunctival bleb	39.80	24.79	7	15899	24	56276137
Vitrectomy	39.57	24.79	9	15897	136	56276025
Macular ischaemia	39.36	24.79	7	15899	26	56276135
Abdominal discomfort	38.68	24.79	15	15891	277259	55998902
Dry eye	38.56	24.79	49	15857	35667	56240494
Vomiting	38.25	24.79	51	15855	498177	55777984
Weight increased	38.22	24.79	9	15897	229694	56046467
Retinal drusen	37.54	24.79	6	15900	9	56276152
Conjunctival erosion	37.52	24.79	8	15898	88	56276073
Arthropathy	37.21	24.79	6	15900	200269	56075892
Treatment failure	36.88	24.79	3	15903	170389	56105772
Inappropriate schedule of product administration	36.65	24.79	76	15830	83311	56192850
Corneal striae	35.86	24.79	5	15901	0	56276161
Peripheral swelling	35.66	24.79	11	15895	234715	56041446
Dysphonia	35.32	24.79	51	15855	41896	56234265
Photophobia	35.08	24.79	32	15874	16018	56260143
Swelling	35.08	24.79	12	15894	239759	56036402
Vitreous degeneration	34.48	24.79	6	15900	19	56276142
Atrial fibrillation	34.29	24.79	87	15819	108810	56167351
Hypotony of eye	33.92	24.79	8	15898	143	56276018
Glare	33.81	24.79	7	15899	66	56276095
Intraocular lens implant	33.66	24.79	9	15897	272	56275889
Angina pectoris	32.79	24.79	40	15866	27936	56248225
Corneal oedema	32.60	24.79	13	15893	1409	56274752
Myocardial ischaemia	32.20	24.79	27	15879	12089	56264072
Macular detachment	32.12	24.79	7	15899	86	56276075
Therapeutic product effect decreased	31.64	24.79	5	15901	169447	56106714
Drug interaction	31.55	24.79	10	15896	209745	56066416
Dyspnoea	30.88	24.79	77	15829	592500	55683661
Hypertensive crisis	30.71	24.79	28	15878	14008	56262153
Sinusitis	30.47	24.79	9	15897	197572	56078589
Haemorrhagic stroke	30.44	24.79	19	15887	5384	56270777
Charles Bonnet syndrome	30.37	24.79	5	15901	10	56276151
Pruritus	30.24	24.79	27	15879	316596	55959565
Iritis	30.12	24.79	15	15891	2748	56273413
Choroidal effusion	29.12	24.79	9	15897	459	56275702
Staphylococcus test positive	29.06	24.79	16	15890	3597	56272564
Abdominal pain	27.29	24.79	20	15886	258785	56017376
Cataract subcapsular	27.26	24.79	9	15897	568	56275593
Completed suicide	27.25	24.79	3	15903	133830	56142331
Nausea	26.93	24.79	118	15788	764060	55512101
Retinal vasculitis	26.92	24.79	10	15896	895	56275266
Corneal abrasion	26.89	24.79	10	15896	898	56275263
Pain in extremity	26.49	24.79	27	15879	297404	55978757
Retinal telangiectasia	26.45	24.79	4	15902	3	56276158
Posterior capsule rupture	26.45	24.79	4	15902	3	56276158
Macular cyst	26.43	24.79	5	15901	28	56276133
Constipation	26.42	24.79	12	15894	201931	56074230
Choroidal detachment	26.29	24.79	7	15899	208	56275953
Weight decreased	26.17	24.79	18	15888	240696	56035465
Conjunctival disorder	26.16	24.79	7	15899	212	56275949
Somnolence	26.02	24.79	7	15899	163406	56112755
Decreased appetite	25.74	24.79	15	15891	219216	56056945
Acute myocardial infarction	25.65	24.79	37	15869	30356	56245805
Retinal injury	25.56	24.79	7	15899	232	56275929
Normal tension glaucoma	25.23	24.79	5	15901	37	56276124

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Visual acuity reduced	2762.43	31.34	729	12267	14614	31669734
Retinal haemorrhage	1162.32	31.34	289	12707	4441	31679907
Macular oedema	997.88	31.34	229	12767	2439	31681909
Death	816.82	31.34	857	12139	359712	31324636
Polypoidal choroidal vasculopathy	745.72	31.34	127	12869	196	31684152
Vitreous haemorrhage	744.00	31.34	174	12822	2022	31682326
Age-related macular degeneration	724.38	31.34	133	12863	385	31683963
Detachment of retinal pigment epithelium	667.31	31.34	122	12874	342	31684006
Endophthalmitis	610.30	31.34	164	12832	3452	31680896
Retinal pigment epithelial tear	586.03	31.34	100	12896	157	31684191
Subretinal fluid	557.50	31.34	100	12896	242	31684106
Retinal oedema	542.15	31.34	107	12889	502	31683846
Vitreous floaters	520.62	31.34	142	12854	3165	31681183
Choroidal neovascularisation	431.08	31.34	77	12919	180	31684168
Diabetic retinal oedema	430.45	31.34	78	12918	204	31684144
Cerebrovascular accident	394.61	31.34	297	12699	79187	31605161
Visual impairment	371.88	31.34	203	12793	31076	31653272
Retinal detachment	311.04	31.34	105	12891	4881	31679467
Eye haemorrhage	298.29	31.34	96	12900	3836	31680512
Intraocular pressure increased	295.29	31.34	102	12894	5085	31679263
Vision blurred	263.38	31.34	181	12815	41734	31642614
Blindness	254.13	31.34	117	12879	12434	31671914
Eye pain	240.71	31.34	112	12884	12192	31672156
Cystoid macular oedema	239.33	31.34	56	12940	649	31683699
Retinal exudates	230.77	31.34	54	12942	626	31683722
Retinal vein occlusion	229.68	31.34	64	12932	1543	31682805
Cerebral infarction	229.36	31.34	139	12857	25838	31658510
Myocardial infarction	218.54	31.34	250	12746	113204	31571144
Retinopathy of prematurity	211.23	31.34	39	12957	117	31684231
Neovascular age-related macular degeneration	204.48	31.34	40	12956	177	31684171
Ocular hypertension	202.26	31.34	50	12946	742	31683606
Retinal thickening	189.39	31.34	29	12967	9	31684339
Cataract	183.81	31.34	117	12879	23690	31660658
Metamorphopsia	175.53	31.34	41	12955	471	31683877
Macular degeneration	171.89	31.34	54	12942	1990	31682358
Vitreous detachment	169.15	31.34	44	12952	809	31683539
Macular hole	158.11	31.34	32	12964	174	31684174
Vitreous opacities	149.68	31.34	33	12963	286	31684062
Retinal disorder	137.91	31.34	38	12958	877	31683471
Diabetic retinopathy	135.87	31.34	43	12953	1623	31682725
Blindness transient	135.75	31.34	45	12951	1972	31682376
Vitritis	120.83	31.34	33	12963	736	31683612
Ocular discomfort	118.74	31.34	40	12956	1843	31682505
Vitreous disorder	116.78	31.34	22	12974	76	31684272
Retinal ischaemia	115.20	31.34	27	12969	315	31684033
Cataract nuclear	115.08	31.34	29	12967	467	31683881
Dry age-related macular degeneration	115.06	31.34	22	12974	84	31684264
Increased insulin requirement	113.48	31.34	21	12975	64	31684284
Disease progression	113.04	31.34	161	12835	90303	31594045
Retinal tear	112.64	31.34	31	12965	712	31683636
Macular fibrosis	112.58	31.34	27	12969	350	31683998
Retinal cyst	111.56	31.34	20	12976	48	31684300
Retinal degeneration	111.22	31.34	28	12968	449	31683899
Glaucoma	109.18	31.34	53	12943	6327	31678021
Subretinal fibrosis	103.66	31.34	20	12976	81	31684267
Anterior chamber inflammation	98.63	31.34	23	12973	262	31684086
Transient ischaemic attack	97.51	31.34	80	12916	23976	31660372
Eye disorder	94.82	31.34	53	12943	8449	31675899
Retinal scar	92.84	31.34	22	12974	270	31684078
Eye inflammation	91.74	31.34	33	12963	1850	31682498
Blindness unilateral	91.73	31.34	41	12955	4056	31680292
Retinal artery occlusion	90.71	31.34	32	12964	1694	31682654
Retinal neovascularisation	89.22	31.34	18	12978	96	31684252
Macular scar	88.88	31.34	15	12981	21	31684327
Suture rupture	88.69	31.34	22	12974	331	31684017
Diarrhoea	87.55	31.34	19	12977	352390	31331958
Hypopyon	82.82	31.34	21	12975	347	31684001
Pyrexia	82.68	31.34	13	12983	303827	31380521
Disease recurrence	81.85	31.34	65	12931	18596	31665752
Ocular hyperaemia	81.71	31.34	51	12945	9958	31674390
Visual field defect	78.03	31.34	37	12959	4191	31680157
Retinal aneurysm	75.58	31.34	16	12980	112	31684236
Serous retinal detachment	74.80	31.34	21	12975	520	31683828
Macular ischaemia	71.73	31.34	14	12982	61	31684287
Haemorrhage	70.78	31.34	92	12904	47242	31637106
Neovascularisation	70.62	31.34	12	12984	18	31684330
Fatigue	68.63	31.34	26	12970	335180	31349168
Ocular vascular disorder	67.23	31.34	15	12981	138	31684210
Hyphaema	65.83	31.34	19	12977	521	31683827
Retinal depigmentation	64.49	31.34	12	12984	38	31684310
Inappropriate schedule of product administration	62.70	31.34	90	12906	50733	31633615
Non-infectious endophthalmitis	60.90	31.34	14	12982	149	31684199
Posterior capsule opacification	59.55	31.34	13	12983	107	31684241
Toxicity to various agents	58.91	31.34	4	12992	181483	31502865
Macular cyst	57.89	31.34	9	12987	4	31684344
Corneal oedema	57.65	31.34	21	12975	1220	31683128
Cutis laxa	57.06	31.34	12	12984	81	31684267
Uveitis	56.30	31.34	35	12961	6781	31677567
Subretinal haematoma	56.03	31.34	9	12987	7	31684341
Foreign body sensation in eyes	55.98	31.34	17	12979	558	31683790
Retinal vascular disorder	55.05	31.34	13	12983	157	31684191
Anterior chamber cell	54.85	31.34	15	12981	336	31684012
Diabetic foot	53.62	31.34	24	12972	2381	31681967
Photopsia	52.75	31.34	22	12974	1838	31682510
Eye oedema	52.35	31.34	17	12979	697	31683651
Nausea	49.32	31.34	33	12963	307914	31376434
Acute kidney injury	48.93	31.34	27	12969	279687	31404661
Retinal vasculitis	48.78	31.34	14	12982	376	31683972
Hypotension	48.76	31.34	12	12984	204606	31479742
Maculopathy	48.29	31.34	17	12979	894	31683454
Cataract traumatic	47.60	31.34	7	12989	0	31684348
Retinopathy proliferative	46.40	31.34	10	12986	77	31684271
Drug interaction	46.37	31.34	14	12982	208529	31475819
Vitreous haze	46.34	31.34	9	12987	38	31684310
Lacrimation increased	43.80	31.34	31	12965	7451	31676897
Conjunctival haemorrhage	41.47	31.34	21	12975	2741	31681607
Keratic precipitates	41.11	31.34	10	12986	138	31684210
Eye irritation	40.48	31.34	28	12968	6490	31677858
Corneal erosion	39.84	31.34	9	12987	88	31684260
Pseudoendophthalmitis	39.76	31.34	8	12988	42	31684306
Aphonia	39.67	31.34	21	12975	3004	31681344
Hypotony of eye	38.80	31.34	9	12987	100	31684248
Decreased appetite	38.45	31.34	8	12988	153209	31531139
Myocardial ischaemia	37.56	31.34	40	12956	16627	31667721
Vitrectomy	37.36	31.34	9	12987	119	31684229
Ischaemic stroke	36.96	31.34	40	12956	16931	31667417
Thrombocytopenia	36.76	31.34	7	12989	142740	31541608
Anaemia	36.74	31.34	21	12975	213501	31470847
Visual acuity reduced transiently	36.31	31.34	8	12988	69	31684279
Ophthalmological examination abnormal	35.24	31.34	7	12989	34	31684314
Corneal disorder	34.48	31.34	13	12983	832	31683516
Poor peripheral circulation	34.25	31.34	15	12981	1412	31682936
Retinoschisis	34.21	31.34	6	12990	12	31684336
Conjunctival hyperaemia	33.71	31.34	17	12979	2199	31682149
Vitreous adhesions	33.58	31.34	6	12990	14	31684334
Visual acuity tests abnormal	33.32	31.34	7	12989	47	31684301
Vomiting	31.94	31.34	27	12969	223946	31460402
Choroidal haemorrhage	31.51	31.34	7	12989	63	31684285
Cataract subcapsular	31.40	31.34	10	12986	385	31683963
Corneal abrasion	31.38	31.34	9	12987	241	31684107

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Visual acuity reduced	4088.49	23.12	1039	18589	26891	70881925
Macular oedema	1372.45	23.12	312	19316	4850	70903966
Endophthalmitis	1338.92	23.12	317	19311	5938	70902878
Retinal haemorrhage	1328.40	23.12	328	19300	7382	70901434
Age-related macular degeneration	1312.65	23.12	236	19392	978	70907838
Polypoidal choroidal vasculopathy	1029.69	23.12	164	19464	247	70908569
Detachment of retinal pigment epithelium	1013.16	23.12	176	19452	568	70908248
Choroidal neovascularisation	925.19	23.12	154	19474	352	70908464
Vitreous haemorrhage	873.10	23.12	200	19428	3212	70905604
Retinal pigment epithelial tear	869.42	23.12	143	19485	294	70908522
Death	826.65	23.12	848	18780	509213	70399603
Subretinal fluid	787.51	23.12	141	19487	566	70908250
Retinal oedema	725.25	23.12	136	19492	742	70908074
Diabetic retinal oedema	674.43	23.12	118	19510	401	70908415
Vitreous floaters	627.87	23.12	176	19452	6528	70902288
Cerebrovascular accident	541.60	23.12	389	19239	143081	70765735
Eye haemorrhage	535.22	23.12	166	19462	8783	70900033
Eye pain	492.85	23.12	223	19405	33879	70874937
Visual impairment	450.98	23.12	279	19349	79971	70828845
Retinal detachment	419.12	23.12	136	19492	8331	70900485
Intraocular pressure increased	400.42	23.12	133	19495	8768	70900048
Retinal vein occlusion	352.78	23.12	95	19533	3021	70905795
Retinal thickening	349.32	23.12	51	19577	21	70908795
Macular hole	347.30	23.12	72	19556	701	70908115
Neovascular age-related macular degeneration	346.69	23.12	64	19564	315	70908501
Blindness	332.62	23.12	151	19477	23076	70885740
Cerebral infarction	329.75	23.12	183	19445	42826	70865990
Retinal exudates	322.99	23.12	73	19555	1097	70907719
Macular degeneration	316.83	23.12	107	19521	7421	70901395
Vision blurred	300.61	23.12	232	19396	94752	70814064
Photopsia	297.17	23.12	92	19536	4829	70903987
Cystoid macular oedema	276.04	23.12	71	19557	1881	70906935
Metamorphopsia	254.10	23.12	60	19568	1103	70907713
Myocardial infarction	228.94	23.12	259	19369	171386	70737430
Macular fibrosis	226.46	23.12	50	19578	671	70908145
Transient ischaemic attack	225.99	23.12	147	19481	45797	70863019
Ocular hypertension	223.47	23.12	56	19572	1332	70907484
Cataract	221.13	23.12	156	19472	55489	70853327
Vitritis	213.99	23.12	56	19572	1590	70907226
Vitreous detachment	205.79	23.12	57	19571	2016	70906800
Disease progression	204.78	23.12	234	19394	156438	70752378
Eye inflammation	203.64	23.12	71	19557	5416	70903400
Retinal ischaemia	198.28	23.12	45	19583	689	70908127
Subretinal fibrosis	191.96	23.12	34	19594	126	70908690
Retinal disorder	191.79	23.12	53	19575	1858	70906958
Retinal neovascularisation	183.92	23.12	32	19596	104	70908712
Diabetic retinopathy	178.44	23.12	55	19573	2842	70905974
Retinal degeneration	176.89	23.12	45	19583	1139	70907677
Retinal tear	175.50	23.12	46	19582	1314	70907502
Retinal depigmentation	174.18	23.12	35	19593	287	70908529
Vitreous opacities	174.17	23.12	39	19589	560	70908256
Retinal cyst	173.99	23.12	30	19598	91	70908725
Retinal artery occlusion	172.25	23.12	54	19574	2952	70905864
Vitreous disorder	170.23	23.12	33	19595	220	70908596
Non-infectious endophthalmitis	168.12	23.12	34	19594	289	70908527
Dry throat	160.82	23.12	63	19565	6665	70902151
Ocular hyperaemia	154.40	23.12	92	19536	24547	70884269
Dry age-related macular degeneration	153.61	23.12	30	19598	209	70908607
Retinal scar	149.08	23.12	32	19596	373	70908443
Ocular discomfort	148.55	23.12	53	19575	4324	70904492
Blindness unilateral	142.09	23.12	59	19569	7254	70901562
Blindness transient	136.64	23.12	50	19578	4386	70904430
Cataract nuclear	135.06	23.12	35	19593	955	70907861
Anterior chamber cell	133.25	23.12	34	19594	871	70907945
Uveitis	129.88	23.12	69	19559	14776	70894040
Eye pruritus	127.92	23.12	68	19560	14579	70894237
Visual field defect	124.34	23.12	56	19572	8382	70900434
Eye discharge	119.68	23.12	48	19580	5399	70903417
Anterior chamber inflammation	117.98	23.12	28	19600	526	70908290
Retinal vascular disorder	117.13	23.12	25	19603	283	70908533
Glaucoma	114.50	23.12	68	19560	18024	70890792
Increased insulin requirement	113.57	23.12	22	19606	146	70908670
Retinopathy of prematurity	109.07	23.12	17	19611	20	70908796
Pharyngeal oedema	107.25	23.12	62	19566	15634	70893182
Macular scar	104.21	23.12	19	19609	86	70908730
Diarrhoea	103.38	23.12	44	19584	783297	70125519
Hypopyon	99.06	23.12	28	19600	1067	70907749
Retinal aneurysm	99.02	23.12	21	19607	230	70908586
Eye disorder	98.46	23.12	65	19563	20720	70888096
Suture rupture	91.61	23.12	23	19605	551	70908265
Choroidal haemorrhage	90.76	23.12	18	19610	137	70908679
Toxicity to various agents	88.92	23.12	4	19624	382168	70526648
Macular ischaemia	87.30	23.12	16	19612	75	70908741
Pyrexia	86.77	23.12	30	19598	606922	70301894
Iridocyclitis	85.98	23.12	33	19595	3302	70905514
Fatigue	83.46	23.12	64	19564	824255	70084561
Serous retinal detachment	82.07	23.12	23	19605	849	70907967
Retinopathy proliferative	81.60	23.12	16	19612	114	70908702
Eye oedema	80	23.12	27	19601	1865	70906951
Haemorrhage	79.97	23.12	107	19521	83708	70825108
Disease recurrence	77.77	23.12	72	19556	37531	70871285
Throat tightness	76.55	23.12	60	19568	24962	70883854
Macular cyst	75.25	23.12	13	19615	40	70908776
Retinal vasculitis	73.86	23.12	23	19605	1229	70907587
Ischaemic stroke	73.60	23.12	64	19564	30756	70878060
Foreign body sensation in eyes	72.84	23.12	25	19603	1817	70906999
Posterior capsule opacification	70.92	23.12	15	19613	162	70908654
Retinoschisis	70.73	23.12	12	19616	32	70908784
Drug interaction	69.91	23.12	11	19617	381430	70527386
Hyphaema	69.74	23.12	20	19608	803	70908013
Exudative retinopathy	69.67	23.12	11	19617	15	70908801
Corneal oedema	69.41	23.12	26	19602	2434	70906382
Rheumatoid arthritis	68.03	23.12	3	19625	291802	70617014
Rash	66.69	23.12	29	19599	510533	70398283
Eye irritation	66.29	23.12	48	19580	17740	70891076
Diabetic foot	66.22	23.12	27	19601	3167	70905649
Subretinal haematoma	64.51	23.12	10	19618	11	70908805
Visual acuity tests abnormal	64.43	23.12	13	19615	109	70908707
Lacrimation increased	63.66	23.12	49	19579	19850	70888966
Nausea	62.62	23.12	87	19541	852001	70056815
Keratic precipitates	62.22	23.12	15	19613	302	70908514
Conjunctival haemorrhage	62.09	23.12	30	19598	5260	70903556
Cutis laxa	61.84	23.12	13	19615	136	70908680
Conjunctival bleb	58.94	23.12	11	19617	58	70908758
Inappropriate schedule of product administration	58.55	23.12	106	19522	107449	70801367
Maculopathy	57.20	23.12	23	19605	2603	70906213
Tachyphylaxis	56.51	23.12	14	19614	317	70908499
Vomiting	55.03	23.12	50	19578	593061	70315755
Hypotension	54.33	23.12	22	19606	404359	70504457
Ophthalmological examination abnormal	52.49	23.12	10	19618	60	70908756
Joint swelling	51.98	23.12	5	19623	253206	70655610
Hypotony of eye	49.90	23.12	12	19616	239	70908577
Vitreous adhesions	49.50	23.12	9	19619	40	70908776
Vitreous haze	49.13	23.12	10	19618	88	70908728
Abdominal pain	48.64	23.12	17	19611	342110	70566706
Ocular vascular disorder	47.61	23.12	13	19615	435	70908381
Weight increased	46.67	23.12	6	19622	242325	70666491
Vitreous degeneration	45.98	23.12	8	19620	26	70908790
Decreased appetite	45.33	23.12	14	19614	304766	70604050
Staphylococcus test positive	44.65	23.12	25	19603	5929	70902887
Retinal pigment epitheliopathy	44.29	23.12	12	19616	390	70908426
Anterior chamber flare	44.06	23.12	10	19618	153	70908663
Retinal pallor	43.16	23.12	6	19622	0	70908816
Pseudoendophthalmitis	42.43	23.12	8	19620	45	70908771
Cataract subcapsular	42.20	23.12	14	19614	917	70907899
Pain	40.55	23.12	70	19558	628746	70280070
Alopecia	40.52	23.12	4	19624	198486	70710330
Drug intolerance	40.21	23.12	7	19621	225680	70683136
Iris neovascularisation	40.21	23.12	8	19620	62	70908754
Acute kidney injury	39.42	23.12	44	19584	474580	70434236
Retinal fibrosis	38.52	23.12	6	19622	7	70908809
Retinal injury	37.77	23.12	10	19618	297	70908519
Macular pigmentation	37.66	23.12	6	19622	9	70908807
Arthralgia	37.26	23.12	51	19577	503339	70405477
Dyspnoea	37.01	23.12	101	19527	769959	70138857
Posterior capsule rupture	36.91	23.12	6	19622	11	70908805
Drug resistance	36.77	23.12	49	19579	38141	70870675
Macular detachment	36.62	23.12	9	19619	197	70908619
Anaemia	36.19	23.12	35	19593	403388	70505428
Angina pectoris	36.14	23.12	55	19573	48328	70860488
Retinal vascular occlusion	35.83	23.12	11	19617	560	70908256
Visual acuity reduced transiently	35.44	23.12	9	19619	226	70908590
Foreign body in eye	35.40	23.12	9	19619	227	70908589
Eye infection	34.76	23.12	26	19602	10092	70898724
Pruritus	34.60	23.12	27	19601	345533	70563283
Haemorrhagic stroke	34.47	23.12	26	19602	10216	70898600
Iritis	33.47	23.12	17	19611	3315	70905501
Blepharitis	33.26	23.12	16	19612	2777	70906039
Retinal drusen	32.58	23.12	6	19622	29	70908787
Pain in extremity	32.39	23.12	26	19602	328056	70580760
Suspected transmission of an infectious agent via product	32.30	23.12	12	19616	1097	70907719
Aphonia	32.29	23.12	24	19604	9227	70899589
Neovascularisation	31.93	23.12	12	19616	1133	70907683
Detachment of macular retinal pigment epithelium	30.82	23.12	5	19623	9	70908807
Dysphonia	30.64	23.12	52	19576	50048	70858768
Corneal disorder	30.64	23.12	14	19614	2165	70906651
Thrombocytopenia	30.49	23.12	14	19614	239096	70669720
Choroidal effusion	30.29	23.12	10	19618	645	70908171
Somnolence	30.13	23.12	11	19617	215595	70693221
Abdominal discomfort	29.91	23.12	11	19617	214647	70694169
Open angle glaucoma	29.73	23.12	9	19619	437	70908379
Charles Bonnet syndrome	29.56	23.12	5	19623	13	70908803
Fundoscopy abnormal	29.46	23.12	6	19622	53	70908763
Weight decreased	28.93	23.12	26	19602	310462	70598354
Conjunctival erosion	28.75	23.12	7	19621	147	70908669
Aneurysm	28.63	23.12	15	19613	3119	70905697
Optical coherence tomography abnormal	28.56	23.12	5	19623	17	70908799
Pancytopenia	28.46	23.12	4	19624	151103	70757713
Conjunctival disorder	28.29	23.12	8	19620	305	70908511
Chorioretinal scar	27.94	23.12	6	19622	70	70908746
Constipation	27.52	23.12	18	19610	252420	70656396
Dry eye	27.43	23.12	39	19589	32243	70876573
Eye injury	27.35	23.12	12	19616	1687	70907129
Choroidal detachment	27.16	23.12	9	19619	587	70908229
Intraocular lens implant	27.06	23.12	8	19620	358	70908458
Peripheral swelling	26.98	23.12	16	19612	236547	70672269
White blood cell count decreased	26.78	23.12	7	19621	170134	70738682
Acute myocardial infarction	26.72	23.12	61	19567	72826	70835990
Oedema peripheral	26.62	23.12	15	19613	228076	70680740
Vitrectomy	26.44	23.12	7	19621	208	70908608
Abnormal sensation in eye	26.42	23.12	12	19616	1830	70906986
Myocardial ischaemia	26.35	23.12	33	19595	24167	70884649
Giant cell arteritis	25.90	23.12	13	19615	2472	70906344
Stomatitis	25.17	23.12	3	19625	128508	70780308
Conjunctival retraction	25.11	23.12	4	19624	6	70908810
Overdose	24.85	23.12	8	19620	169737	70739079
Aspartate aminotransferase increased	24.78	23.12	3	19625	126975	70781841
Macular thickening	24.73	23.12	4	19624	7	70908809
Concomitant disease aggravated	24.66	23.12	23	19605	12091	70896725
No adverse event	24.65	23.12	37	19591	32116	70876700
Sudden visual loss	24.46	23.12	5	19623	45	70908771
Insomnia	24.46	23.12	15	19613	217791	70691025
Asthenopia	24.41	23.12	12	19616	2184	70906632
Arthropathy	23.95	23.12	6	19622	150051	70758765
Corneal erosion	23.41	23.12	7	19621	326	70908490
Punctate keratitis	23.34	23.12	9	19619	911	70907905
Anterior chamber disorder	23.25	23.12	6	19622	161	70908655
Ocular ischaemic syndrome	23.23	23.12	4	19624	12	70908804

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	S01LA04	SENSORY ORGANS OPHTHALMOLOGICALS OCULAR VASCULAR DISORDER AGENTS Antineovascularisation agents
MeSH PA	D020533	Angiogenesis Inhibitors
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D006131	Growth Inhibitors
MeSH PA	D006133	Growth Substances
FDA MoA	N0000193542	Vascular Endothelial Growth Factor Inhibitors
FDA EPC	N0000193543	Vascular Endothelial Growth Factor Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetic retinopathy	indication	4855003	DOID:8947
Choroidal retinal neovascularization	indication	75971007
Central retinal vein occlusion with macular edema	indication	232039004
Branch retinal vein occlusion with macular edema	indication	232048009
Age related macular degeneration	indication	267718000	DOID:10871
Macular edema due to diabetes mellitus	indication	312912001	DOID:9191
Exudative age-related macular degeneration	indication	414173003	DOID:10873
Retinopathy of prematurity	indication	415297005	DOID:13025
Eye infection	contraindication	128351009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Vascular endothelial growth factor A	Secreted	P15692	VEGFA_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D05697	KEGG_DRUG
4025260	VUID
N0000179788	NUI
CHEMBL1201825	ChEMBL_ID
C000719192	MESH_SUPPLEMENTAL_RECORD_UI
6779	IUPHAR_LIGAND_ID
DB01270	DRUGBANK_ID
ZL1R02VT79	UNII
2602351	RXNORM
21678	MMSL
350639	MMSL
39922	MMSL
83454	MMSL
011622	NDDF
018852	NDDF
422456007	SNOMEDCT_US
425256004	SNOMEDCT_US
4025260	VANDF
4041511	VANDF
D000069579	MESH_DESCRIPTOR_UI
C1566537	UMLSCUI
8313	INN_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Susvimo	HUMAN PRESCRIPTION DRUG LABEL	1	50242-078	INJECTION, SOLUTION	100 mg	INTRAVITREAL	BLA	30 sections
Susvimo	HUMAN PRESCRIPTION DRUG LABEL	1	50242-078	INJECTION, SOLUTION	100 mg	INTRAVITREAL	BLA	30 sections
LUCENTIS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-080	INJECTION, SOLUTION	10 mg	INTRAVITREAL	BLA	28 sections
LUCENTIS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-082	INJECTION, SOLUTION	6 mg	INTRAVITREAL	BLA	28 sections
Byooviz nuna	HUMAN PRESCRIPTION DRUG LABEL	1	64406-019	INJECTION, SOLUTION	10 mg	INTRAVITREAL	BLA	30 sections
Byooviz nuna	HUMAN PRESCRIPTION DRUG LABEL	1	64406-019	INJECTION, SOLUTION	10 mg	INTRAVITREAL	BLA	30 sections
CIMERLI	HUMAN PRESCRIPTION DRUG LABEL	1	70114-440	INJECTION, SOLUTION	0.30 mg	INTRAVITREAL	BLA	30 sections
CIMERLI	HUMAN PRESCRIPTION DRUG LABEL	1	70114-441	INJECTION, SOLUTION	0.50 mg	INTRAVITREAL	BLA	30 sections