All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

ranibizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
humanized origin	4971	347396-82-1

Description:

Molecule	Description
Synonyms: ranibizumab-nuna byooviz ranibizumab lucentis ranibizimumab ranibizumab (genetical recombination)	A recombinant humanized monoclonal antibody fragment that binds VEGF-A to prevent its binding to VEGFR-1 and VEGFR-2 receptors. This activity reduces vessel permeability and angiogenesis in the treatment of neovascular age-related MACULAR DEGENERATION. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Jan. 21, 2009	PMDA	Novartis Pharma
June 30, 2006	FDA	GENENTECH
Jan. 22, 2007	EMA	Novartis Europharm Limited

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Visual acuity reduced	3082.95	26.08	745	16652	22665	90588385
Endophthalmitis	1347.89	26.08	283	17114	4402	90606648
Death	1289.01	26.08	894	16503	455657	90155393
Retinal haemorrhage	989.42	26.08	228	17169	5536	90605514
Cerebrovascular accident	835.78	26.08	427	16970	123106	90487944
Blindness	820.78	26.08	273	17124	26295	90584755
Retinal pigment epithelial tear	747.97	26.08	112	17285	159	90610891
Detachment of retinal pigment epithelium	735.05	26.08	120	17277	385	90610665
Eye haemorrhage	673.45	26.08	188	17209	9992	90601058
No adverse event	665.40	26.08	303	17094	67679	90543371
Retinal oedema	631.66	26.08	118	17279	958	90610092
Vitreous floaters	623.24	26.08	166	17231	7383	90603667
Visual impairment	588.54	26.08	347	17050	132018	90479032
Macular oedema	581.74	26.08	144	17253	4765	90606285
Vitreous haemorrhage	543.10	26.08	121	17276	2505	90608545
Subretinal fluid	528.15	26.08	95	17302	609	90610441
Eye pain	515.94	26.08	223	17174	43945	90567105
Age-related macular degeneration	447.33	26.08	83	17314	646	90610404
Photopsia	374.70	26.08	102	17295	4922	90606128
Metamorphopsia	356.03	26.08	77	17320	1380	90609670
Eye discharge	349.83	26.08	108	17289	8150	90602900
Vision blurred	341.08	26.08	230	17167	110063	90500987
Intraocular pressure increased	327.00	26.08	99	17298	6994	90604056
Eye pruritus	288.65	26.08	131	17266	28896	90582154
Choroidal neovascularisation	286.19	26.08	52	17345	355	90610695
Eye inflammation	267.57	26.08	87	17310	7764	90603286
Retinal exudates	264.32	26.08	53	17344	643	90610407
Myocardial infarction	251.22	26.08	188	17209	105784	90505266
Retinal detachment	250.48	26.08	80	17317	6742	90604308
Transient ischaemic attack	247.67	26.08	134	17263	43042	90568008
Polypoidal choroidal vasculopathy	245.73	26.08	36	17361	39	90611011
Vitritis	235.44	26.08	56	17341	1558	90609492
Macular hole	229.14	26.08	50	17347	935	90610115
Retinal thickening	224.46	26.08	43	17354	404	90610646
Cystoid macular oedema	220.79	26.08	56	17341	2044	90609006
Eye irritation	219.00	26.08	114	17283	33864	90577186
Vitreous detachment	199.53	26.08	53	17344	2325	90608725
Dry throat	191.75	26.08	68	17329	7892	90603158
Retinal vein occlusion	191.06	26.08	52	17345	2504	90608546
Non-infectious endophthalmitis	188.74	26.08	35	17362	271	90610779
Macular fibrosis	179.13	26.08	35	17362	368	90610682
Iridocyclitis	176.90	26.08	53	17344	3608	90607442
Retinal disorder	176.48	26.08	46	17351	1873	90609177
Blindness unilateral	167.23	26.08	61	17336	7675	90603375
Subretinal fibrosis	164.52	26.08	27	17370	90	90610960
Retinal depigmentation	163.11	26.08	31	17366	278	90610772
Retinal scar	162.71	26.08	28	17369	133	90610917
Pharyngeal oedema	162.12	26.08	70	17327	13701	90597349
Uveitis	161.93	26.08	73	17324	15830	90595220
Ocular hyperaemia	161.33	26.08	93	17304	33705	90577345
Cataract nuclear	159.78	26.08	38	17359	1056	90609994
Vitreous opacities	156.00	26.08	32	17365	438	90610612
Off label use	153.78	26.08	511	16886	1101741	89509309
Cerebral infarction	153.73	26.08	83	17314	26513	90584537
Anterior chamber cell	147.14	26.08	33	17364	703	90610347
Retinal neovascularisation	142.75	26.08	23	17374	66	90610984
Cataract	142.64	26.08	115	17282	71977	90539073
Retinal cyst	139.84	26.08	23	17374	78	90610972
Macular degeneration	133.72	26.08	86	17311	37884	90573166
Retinal degeneration	133.68	26.08	33	17364	1076	90609974
Macular scar	129.55	26.08	22	17375	95	90610955
Ocular hypertension	129.40	26.08	35	17362	1645	90609405
Visual field defect	116.88	26.08	46	17351	7120	90603930
Retinal artery occlusion	114.59	26.08	34	17363	2237	90608813
Retinal ischaemia	105.04	26.08	23	17374	437	90610613
Retinal tear	100.44	26.08	28	17369	1474	90609576
Throat tightness	94.57	26.08	63	17334	29421	90581629
Retinal vascular disorder	93.67	26.08	19	17378	245	90610805
Vitreous disorder	91.97	26.08	17	17380	129	90610921
Disease progression	89.23	26.08	129	17268	156486	90454564
Hypopyon	84.48	26.08	22	17375	892	90610158
Retinal aneurysm	84.11	26.08	17	17380	215	90610835
Conjunctival erosion	83.73	26.08	16	17381	148	90610902
Glaucoma	80.53	26.08	50	17347	20705	90590345
Diarrhoea	79.13	26.08	41	17356	939149	89671901
Lacrimation increased	77.70	26.08	54	17343	27008	90584042
Dry age-related macular degeneration	76.63	26.08	16	17381	240	90610810
Rash	76.07	26.08	29	17368	796071	89814979
Alopecia	75.54	26.08	5	17392	495066	90115984
Macular pigmentation	75.04	26.08	11	17386	12	90611038
Retinal vasculitis	73.11	26.08	22	17375	1519	90609531
Eye oedema	72.08	26.08	23	17374	1929	90609121
Fatigue	71.55	26.08	70	17327	1153953	89457097
Foreign body sensation in eyes	71.23	26.08	26	17371	3274	90607776
Cutis laxa	70.10	26.08	14	17383	166	90610884
Conjunctival bleb	69.55	26.08	12	17385	58	90610992
Disease recurrence	65.95	26.08	56	17341	37597	90573453
Eye infection	64.75	26.08	38	17359	14216	90596834
Retinal drusen	64.28	26.08	10	17387	21	90611029
Joint swelling	64.15	26.08	10	17387	503290	90107760
Foreign body in eye	63.30	26.08	13	17384	179	90610871
Neovascular age-related macular degeneration	63.02	26.08	15	17382	418	90610632
Anterior chamber flare	62.61	26.08	12	17385	113	90610937
Maculopathy	62.60	26.08	22	17375	2484	90608566
Ophthalmological examination abnormal	62.51	26.08	12	17385	114	90610936
Eye disorder	61.26	26.08	47	17350	27343	90583707
Diabetic retinopathy	60.98	26.08	22	17375	2680	90608370
Ischaemic stroke	60.76	26.08	43	17354	22123	90588927
Drug intolerance	59.10	26.08	8	17389	447583	90163467
Suspected transmission of an infectious agent via product	58.79	26.08	14	17383	391	90610659
Ocular discomfort	57.80	26.08	27	17370	6343	90604707
Choroidal haemorrhage	57.68	26.08	10	17387	50	90611000
Posterior capsule opacification	57.16	26.08	12	17385	185	90610865
Retinoschisis	53.14	26.08	8	17389	12	90611038
Conjunctival haemorrhage	52.68	26.08	22	17375	3962	90607088
Pyrexia	52.39	26.08	31	17366	660454	89950596
Weight increased	51.68	26.08	9	17388	417918	90193132
Rheumatoid arthritis	51.56	26.08	5	17392	362609	90248441
Pain	51.33	26.08	70	17327	996271	89614779
Arthropathy	49.66	26.08	6	17391	366236	90244814
Blepharitis	49.38	26.08	21	17376	3955	90607095
Retinal fibrosis	48.06	26.08	7	17390	7	90611043
Abdominal discomfort	47.87	26.08	16	17381	477312	90133738
Peripheral swelling	46.71	26.08	11	17386	413095	90197955
Treatment failure	46.53	26.08	3	17394	303925	90307125
Atrial fibrillation	46.25	26.08	88	17309	133523	90477527
Tachyphylaxis	45.06	26.08	11	17386	342	90610708
Corneal oedema	44.86	26.08	16	17381	1885	90609165
Vomiting	44.06	26.08	52	17345	788241	89822809
Vitrectomy	43.77	26.08	10	17387	232	90610818
Retinopathy proliferative	43.36	26.08	8	17389	60	90610990
Anterior chamber inflammation	43.16	26.08	11	17386	409	90610641
Exudative retinopathy	42.29	26.08	6	17391	4	90611046
Photophobia	42.17	26.08	34	17363	21235	90589815
Swelling	42.09	26.08	14	17383	419044	90192006
Dysphonia	41.92	26.08	56	17341	63028	90548022
Visual acuity tests abnormal	41.51	26.08	9	17388	163	90610887
Stomatitis	41.20	26.08	3	17394	274695	90336355
Iritis	40.97	26.08	18	17379	3668	90607382
Pericarditis	40.38	26.08	3	17394	270148	90340902
Arthralgia	39.73	26.08	55	17342	778467	89832583
Dry eye	39.38	26.08	52	17345	57879	90553171
Sinusitis	39.04	26.08	9	17388	343079	90267971
Hypertensive crisis	38.64	26.08	30	17367	17754	90593296
Vitreal cells	38.57	26.08	8	17389	116	90610934
Myocardial ischaemia	38.33	26.08	27	17370	13787	90597263
Macular ischaemia	38.24	26.08	7	17390	50	90611000
Staphylococcus test positive	38.14	26.08	18	17379	4327	90606723
Device issue	38.10	26.08	37	17360	29500	90581550
Angina pectoris	37.81	26.08	42	17355	39118	90571932
Pruritus	36.83	26.08	30	17367	541495	90069555
Vitreous adhesions	35.87	26.08	7	17390	73	90610977
Vitreous degeneration	35.50	26.08	6	17391	25	90611025
Infection	34.81	26.08	13	17384	362081	90248969
Acute myocardial infarction	34.69	26.08	38	17359	34852	90576198
Intraocular lens implant	34.16	26.08	9	17388	382	90610668
Glare	34.11	26.08	7	17390	96	90610954
Haemorrhagic stroke	34.01	26.08	19	17378	6477	90604573
Decreased appetite	33.79	26.08	15	17382	376525	90234525
Macular detachment	33.78	26.08	7	17390	101	90610949
Hypotony of eye	33.71	26.08	8	17389	220	90610830
Conjunctival hyperaemia	33.69	26.08	15	17382	3154	90607896
Diabetic retinal oedema	33.48	26.08	9	17388	413	90610637
Cataract subcapsular	32.81	26.08	10	17387	721	90610329
Dyspnoea	32.57	26.08	76	17321	880879	89730171
Cataract cortical	31.65	26.08	6	17391	53	90610997
Conjunctival disorder	31.22	26.08	8	17389	304	90610746
Gastrointestinal disorder	30.69	26.08	6	17391	256681	90354369
Corneal opacity	30.64	26.08	10	17387	901	90610149
Psoriatic arthropathy	30.30	26.08	4	17393	228331	90382719
Abdominal pain upper	30.24	26.08	13	17384	332661	90278389
Pain in extremity	29.34	26.08	26	17371	450503	90160547
Conjunctival retraction	29.18	26.08	5	17392	23	90611027
Xerophthalmia	29.18	26.08	9	17388	675	90610375
Retinal vascular occlusion	28.48	26.08	8	17389	433	90610617
Weight decreased	28.46	26.08	19	17378	379891	90231159
Blister	28.39	26.08	7	17390	254991	90356059
Corneal striae	28.36	26.08	5	17392	28	90611022
Optical coherence tomography abnormal	28.24	26.08	7	17390	232	90610818
Macular cyst	28.07	26.08	5	17392	30	90611020
Posterior capsule rupture	28.00	26.08	4	17393	3	90611047
Choroidal effusion	27.92	26.08	9	17388	780	90610270
Musculoskeletal stiffness	27.90	26.08	11	17386	296521	90314529
Wheezing	27.57	26.08	6	17391	238074	90372976
Normal tension glaucoma	27.04	26.08	5	17392	38	90611012
Corneal abrasion	27.04	26.08	10	17387	1306	90609744
Choroidal detachment	26.92	26.08	7	17390	282	90610768
Abdominal pain	26.78	26.08	22	17375	395699	90215351
Abnormal sensation in eye	26.45	26.08	11	17386	1960	90609090
Open angle glaucoma	26.43	26.08	7	17390	303	90610747
Product use issue	26.23	26.08	129	17268	329790	90281260
Keratic precipitates	26.15	26.08	7	17390	316	90610734

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Visual acuity reduced	2988.39	30.78	769	13824	16781	42589961
Retinal haemorrhage	1247.31	30.78	307	14286	5463	42601279
Macular oedema	873.52	30.78	210	14383	3359	42603383
Vitreous haemorrhage	858.13	30.78	197	14396	2550	42604192
Death	845.40	30.78	910	13683	470275	42136467
Subretinal fluid	725.47	30.78	137	14456	606	42606136
Endophthalmitis	667.90	30.78	177	14416	4256	42602486
Detachment of retinal pigment epithelium	649.50	30.78	121	14472	489	42606253
Retinal oedema	611.51	30.78	124	14469	844	42605898
Retinal pigment epithelial tear	605.02	30.78	104	14489	230	42606512
Vitreous floaters	571.58	30.78	155	14438	4075	42602667
No adverse event	518.30	30.78	257	14336	38764	42567978
Visual impairment	476.88	30.78	251	14342	42862	42563880
Cerebrovascular accident	402.16	30.78	303	14290	96857	42509885
Choroidal neovascularisation	382.08	30.78	69	14524	224	42606518
Eye haemorrhage	345.39	30.78	108	14485	4722	42602020
Polypoidal choroidal vasculopathy	339.31	30.78	58	14535	122	42606620
Intraocular pressure increased	338.54	30.78	114	14479	6319	42600423
Retinal detachment	325.17	30.78	111	14482	6414	42600328
Vision blurred	284.94	30.78	195	14398	53504	42553238
Blindness	273.21	30.78	130	14463	17848	42588894
Retinal exudates	255.71	30.78	59	14534	778	42605964
Eye pain	252.24	30.78	121	14472	16909	42589833
Myocardial infarction	244.36	30.78	254	14339	123755	42482987
Cerebral infarction	234.20	30.78	141	14452	31028	42575714
Cystoid macular oedema	212.96	30.78	53	14540	980	42605762
Cataract	210.87	30.78	131	14462	30473	42576269
Vitritis	207.80	30.78	54	14539	1195	42605547
Ocular hypertension	197.94	30.78	51	14542	1090	42605652
Metamorphopsia	179.75	30.78	42	14551	587	42606155
Macular hole	169.96	30.78	36	14557	310	42606432
Vitreous detachment	169.38	30.78	44	14549	972	42605770
Vitreous opacities	169.38	30.78	38	14555	438	42606304
Retinal disorder	158.35	30.78	43	14550	1132	42605610
Blindness transient	156.91	30.78	52	14541	2737	42604005
Retinal thickening	153.00	30.78	34	14559	374	42606368
Retinal vein occlusion	152.96	30.78	47	14546	1934	42604808
Diabetic retinopathy	151.08	30.78	47	14546	2016	42604726
Increased insulin requirement	143.70	30.78	27	14566	115	42606627
Ocular discomfort	132.93	30.78	47	14546	3010	42603732
Macular degeneration	129.57	30.78	44	14549	2497	42604245
Dry age-related macular degeneration	129.55	30.78	24	14569	93	42606649
Retinal tear	125.84	30.78	35	14558	1009	42605733
Cataract nuclear	125.55	30.78	33	14560	764	42605978
Eye inflammation	123.11	30.78	45	14548	3173	42603569
Disease recurrence	118.88	30.78	91	14502	29587	42577155
Subretinal fibrosis	118.00	30.78	22	14571	89	42606653
Eye disorder	117.93	30.78	64	14529	11548	42595194
Suture rupture	116.17	30.78	28	14565	450	42606292
Retinal ischaemia	114.97	30.78	28	14565	471	42606271
Retinal degeneration	114.61	30.78	30	14563	683	42606059
Vitreous disorder	114.60	30.78	23	14570	147	42606595
Macular fibrosis	111.48	30.78	26	14567	360	42606382
Glaucoma	111.22	30.78	55	14538	8193	42598549
Retinal cyst	108.48	30.78	20	14573	75	42606667
Anterior chamber inflammation	105.09	30.78	25	14568	379	42606363
Macular scar	103.71	30.78	17	14576	24	42606718
Disease progression	102.00	30.78	179	14414	143477	42463265
Blindness unilateral	100.65	30.78	45	14548	5343	42601399
Neovascular age-related macular degeneration	100.45	30.78	22	14571	225	42606517
Diarrhoea	99.23	30.78	19	14574	460830	42145912
Haemorrhage	97.93	30.78	112	14481	60451	42546291
Retinal scar	96.11	30.78	23	14570	358	42606384
Off label use	95.42	30.78	450	14143	637885	41968857
Ocular hyperaemia	94.15	30.78	62	14531	15901	42590841
Transient ischaemic attack	92.40	30.78	83	14510	33656	42573086
Retinal artery occlusion	92.31	30.78	33	14560	2182	42604560
Pyrexia	89.70	30.78	14	14579	394028	42212714
Hypopyon	88.36	30.78	23	14570	512	42606230
Retinal neovascularisation	87.06	30.78	18	14575	136	42606606
Retinal depigmentation	86.57	30.78	16	14577	61	42606681
Retinal vasculitis	83.47	30.78	23	14570	640	42606102
Age-related macular degeneration	82.42	30.78	20	14573	331	42606411
Uveitis	80.28	30.78	46	14547	9212	42597530
Serous retinal detachment	79.72	30.78	24	14569	920	42605822
Visual field defect	78.91	30.78	37	14556	4901	42601841
Retinal aneurysm	77.14	30.78	16	14577	123	42606619
Hyphaema	77.07	30.78	22	14571	698	42606044
Neovascularisation	75.51	30.78	13	14580	29	42606713
Diabetic retinal oedema	74.31	30.78	17	14576	215	42606527
Non-infectious endophthalmitis	71.94	30.78	17	14576	250	42606492
Diabetic foot	71.59	30.78	30	14563	3043	42603699
Posterior capsule opacification	68.43	30.78	15	14578	154	42606588
Corneal oedema	68.06	30.78	24	14569	1524	42605218
Anterior chamber cell	67.16	30.78	18	14575	450	42606292
Ocular vascular disorder	66.92	30.78	15	14578	172	42606570
Macular ischaemia	66.68	30.78	15	14578	175	42606567
Fatigue	65.34	30.78	34	14559	435607	42171135
Toxicity to various agents	62.74	30.78	4	14589	229132	42377610
Macular cyst	59.51	30.78	9	14584	4	42606738
Retinal vascular disorder	59.36	30.78	14	14579	204	42606538
Eye oedema	58.88	30.78	19	14574	918	42605824
Subretinal haematoma	57.65	30.78	9	14584	7	42606735
Acute kidney injury	57.57	30.78	27	14566	367310	42239432
Cutis laxa	56.47	30.78	12	14581	105	42606637
Nausea	55.12	30.78	34	14559	396765	42209977
Photopsia	54.55	30.78	23	14570	2369	42604373
Foreign body sensation in eyes	54.49	30.78	18	14575	937	42605805
Aphonia	53.71	30.78	27	14566	4162	42602580
Retinopathy proliferative	53.10	30.78	11	14582	84	42606658
Xerophthalmia	51.73	30.78	12	14581	162	42606580
Drug interaction	51.35	30.78	14	14579	266985	42339757
Hypotension	50.51	30.78	13	14580	257618	42349124
Neutropenia	50.35	30.78	5	14588	199426	42407316
Cataract traumatic	48.86	30.78	7	14586	0	42606742
Device issue	48.82	30.78	39	14554	13470	42593272
Keratic precipitates	47.89	30.78	12	14581	228	42606514
Iridocyclitis	46.25	30.78	20	14573	2191	42604551
Conjunctival haemorrhage	45.97	30.78	23	14570	3510	42603232
Vitreous haze	45.33	30.78	9	14584	54	42606688
Maculopathy	44.73	30.78	16	14577	1059	42605683
Poor peripheral circulation	44.66	30.78	18	14575	1653	42605089
Corneal erosion	44.43	30.78	10	14583	117	42606625
Vitrectomy	42.84	30.78	10	14583	139	42606603
Thrombocytopenia	42.65	30.78	7	14586	190272	42416470
Inappropriate schedule of product administration	42.14	30.78	98	14495	95804	42510938
Hypotony of eye	42.12	30.78	11	14582	248	42606494
Anaemia	41.75	30.78	22	14571	280256	42326486
Cataract subcapsular	41.72	30.78	13	14580	560	42606182
Myocardial ischaemia	41.47	30.78	40	14553	17722	42589020
Decreased appetite	41.35	30.78	8	14585	193129	42413613
Visual acuity reduced transiently	38.69	30.78	9	14584	123	42606619
Lacrimation increased	38.39	30.78	32	14561	11726	42595016
Conjunctival bleb	37.61	30.78	7	14586	28	42606714
Conjunctival hyperaemia	36.45	30.78	19	14574	3157	42603585
Pseudoendophthalmitis	36.42	30.78	8	14585	83	42606659
Intraocular lens implant	36.40	30.78	10	14583	275	42606467
Ophthalmological examination abnormal	36.01	30.78	7	14586	37	42606705
Vomiting	35.96	30.78	28	14565	289695	42317047
Visual acuity tests abnormal	35.91	30.78	8	14585	89	42606653
Ischaemic stroke	35.69	30.78	41	14552	22192	42584550
Choroidal haemorrhage	34.84	30.78	8	14585	103	42606639
Retinoschisis	34.09	30.78	6	14587	16	42606726
Rash	34.07	30.78	27	14566	276927	42329815
Corneal disorder	33.90	30.78	13	14580	1046	42605696
Vitreous adhesions	33.82	30.78	6	14587	17	42606725
Iritis	33.65	30.78	15	14578	1767	42604975
Eye irritation	33.27	30.78	29	14564	11289	42595453
Conjunctival erosion	32.44	30.78	6	14587	23	42606719
Constipation	32.14	30.78	8	14585	162283	42444459
Somnolence	32.04	30.78	5	14588	141100	42465642
Tachyphylaxis	31.98	30.78	8	14585	151	42606591
Abdominal pain	31.34	30.78	13	14580	190458	42416284
Corneal abrasion	31.16	30.78	9	14584	298	42606444

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Visual acuity reduced	4590.01	24.57	1102	21210	31071	110535916
Retinal haemorrhage	1519.06	24.57	358	21954	9143	110557844
Endophthalmitis	1518.28	24.57	348	21964	7839	110559148
No adverse event	1308.82	24.57	509	21803	73330	110493657
Macular oedema	1168.54	24.57	273	22039	6693	110560294
Subretinal fluid	1108.63	24.57	198	22114	1146	110565841
Detachment of retinal pigment epithelium	1036.10	24.57	179	22133	826	110566161
Vitreous haemorrhage	995.03	24.57	222	22090	4398	110562589
Retinal pigment epithelial tear	917.09	24.57	146	22166	354	110566633
Death	905.46	24.57	891	21421	697978	109869009
Retinal oedema	887.18	24.57	169	22143	1458	110565529
Choroidal neovascularisation	723.79	24.57	121	22191	438	110566549
Vitreous floaters	721.39	24.57	196	22116	8938	110558049
Eye haemorrhage	615.11	24.57	183	22129	11591	110555396
Cerebrovascular accident	589.18	24.57	397	21915	180887	110386100
Visual impairment	572.06	24.57	349	21963	134079	110432908
Polypoidal choroidal vasculopathy	555.21	24.57	86	22226	161	110566826
Eye pain	531.46	24.57	240	22072	49859	110517128
Age-related macular degeneration	480.33	24.57	93	22219	880	110566107
Intraocular pressure increased	477.95	24.57	148	22164	10728	110556259
Retinal detachment	449.92	24.57	142	22170	10958	110556029
Blindness	394.45	24.57	177	22135	36182	110530805
Macular hole	390.58	24.57	79	22233	952	110566035
Retinal exudates	384.76	24.57	81	22231	1203	110565784
Vision blurred	377.24	24.57	265	22047	128757	110438230
Retinal thickening	372.80	24.57	63	22249	247	110566740
Cerebral infarction	366.30	24.57	188	22124	51650	110515337
Vitritis	331.29	24.57	82	22230	2571	110564416
Photopsia	321.93	24.57	96	22216	6118	110560869
Eye inflammation	309.06	24.57	102	22210	9069	110557918
Myocardial infarction	286.30	24.57	266	22046	191817	110375170
Off label use	265.30	24.57	779	21533	1499406	109067581
Metamorphopsia	257.90	24.57	61	22251	1572	110565415
Cataract	257.45	24.57	174	22138	79311	110487676
Retinal vein occlusion	252.15	24.57	72	22240	3935	110563052
Macular fibrosis	241.99	24.57	50	22262	674	110566313
Transient ischaemic attack	241.13	24.57	154	22158	63828	110503159
Cystoid macular oedema	234.65	24.57	63	22249	2737	110564250
Vitreous opacities	231.75	24.57	50	22262	839	110566148
Retinal disorder	230.49	24.57	60	22252	2310	110564677
Ocular hypertension	229.54	24.57	60	22252	2348	110564639
Vitreous detachment	223.51	24.57	60	22252	2605	110564382
Disease progression	211.28	24.57	253	22059	243781	110323206
Subretinal fibrosis	207.58	24.57	36	22276	170	110566817
Non-infectious endophthalmitis	206.19	24.57	41	22271	450	110566537
Retinal depigmentation	205.61	24.57	39	22273	327	110566660
Retinal ischaemia	203.68	24.57	46	22266	961	110566026
Macular degeneration	202.07	24.57	95	22217	21564	110545423
Retinal degeneration	200.51	24.57	50	22262	1616	110565371
Diabetic retinopathy	197.43	24.57	58	22254	3506	110563481
Retinal tear	192.01	24.57	50	22262	1927	110565060
Retinal cyst	189.43	24.57	32	22280	125	110566862
Retinal artery occlusion	187.37	24.57	58	22254	4191	110562796
Retinal neovascularisation	186.86	24.57	34	22278	221	110566766
Ocular hyperaemia	184.86	24.57	109	22203	39177	110527810
Dry age-related macular degeneration	180.67	24.57	34	22278	272	110566715
Uveitis	180.56	24.57	88	22224	21622	110545365
Dry throat	178.55	24.57	68	22244	9170	110557817
Vitreous disorder	172.35	24.57	34	22278	357	110566630
Iridocyclitis	169.65	24.57	57	22255	5351	110561636
Blindness unilateral	167.69	24.57	66	22246	9720	110557267
Anterior chamber cell	163.88	24.57	40	22272	1181	110565806
Ocular discomfort	162.00	24.57	62	22250	8471	110558516
Blindness transient	160.40	24.57	56	22256	5900	110561087
Retinal scar	159.62	24.57	33	22279	446	110566541
Cataract nuclear	158.27	24.57	40	22272	1366	110565621
Retinal vasculitis	152.54	24.57	42	22270	2007	110564980
Increased insulin requirement	144.83	24.57	27	22285	204	110566783
Visual field defect	138.48	24.57	58	22254	10014	110556973
Macular scar	137.59	24.57	23	22289	83	110566904
Neovascular age-related macular degeneration	136.18	24.57	30	22282	557	110566430
Pharyngeal oedema	134.83	24.57	66	22246	16362	110550625
Eye discharge	132.52	24.57	54	22258	8700	110558287
Retinal vascular disorder	129.44	24.57	27	22285	382	110566605
Hypopyon	128.24	24.57	34	22278	1406	110565581
Glaucoma	126.08	24.57	70	22242	22447	110544540
Eye disorder	125.06	24.57	76	22236	28830	110538157
Suture rupture	119.75	24.57	28	22284	685	110566302
Anterior chamber inflammation	117.43	24.57	28	22284	747	110566240
Diarrhoea	113.93	24.57	44	22268	1139461	109427526
Haemorrhage	109.66	24.57	121	22191	106571	110460416
Eye pruritus	109.02	24.57	73	22239	32702	110534285
Retinal aneurysm	103.65	24.57	21	22291	255	110566732
Disease recurrence	101.79	24.57	90	22222	60694	110506293
Eye oedema	100.56	24.57	32	22280	2530	110564457
Device issue	98.56	24.57	70	22242	34465	110532522
Choroidal haemorrhage	98.08	24.57	19	22293	180	110566807
Pyrexia	96	24.57	31	22281	898234	109668753
Corneal oedema	93.84	24.57	32	22280	3141	110563846
Serous retinal detachment	91.68	24.57	27	22285	1645	110565342
Conjunctival bleb	90.33	24.57	17	22295	136	110566851
Retinopathy proliferative	89.68	24.57	17	22295	142	110566845
Posterior capsule opacification	86.74	24.57	18	22294	248	110566739
Throat tightness	86.73	24.57	64	22248	33425	110533562
Diabetic foot	85.86	24.57	32	22280	4063	110562924
Hyphaema	83.83	24.57	23	22289	1084	110565903
Macular ischaemia	82.62	24.57	17	22295	224	110566763
Toxicity to various agents	80.40	24.57	4	22308	480551	110086436
Macular cyst	78.64	24.57	13	22299	43	110566944
Fatigue	78.58	24.57	78	22234	1215880	109351107
Xerophthalmia	77.81	24.57	21	22291	930	110566057
Retinoschisis	77.74	24.57	13	22299	47	110566940
Foreign body sensation in eyes	77.09	24.57	28	22284	3306	110563681
Ischaemic stroke	76.98	24.57	65	22247	41198	110525789
Rash	76.61	24.57	35	22277	820929	109746058
Visual acuity tests abnormal	75.48	24.57	15	22297	164	110566823
Lacrimation increased	70.96	24.57	55	22257	30895	110536092
Joint swelling	70.09	24.57	5	22307	442840	110124147
Keratic precipitates	68.47	24.57	17	22295	539	110566448
Conjunctival haemorrhage	67.78	24.57	31	22281	6602	110560385
Vomiting	67.77	24.57	51	22261	910624	109656363
Exudative retinopathy	66.34	24.57	10	22302	14	110566973
Cutis laxa	65.43	24.57	13	22299	142	110566845
Drug interaction	63.54	24.57	12	22300	500171	110066816
Nausea	63.19	24.57	95	22217	1235595	109331392
Weight increased	62.92	24.57	6	22306	419638	110147349
Ophthalmological examination abnormal	62.73	24.57	11	22301	56	110566931
Anterior chamber flare	61.00	24.57	13	22299	205	110566782
Eye irritation	60.97	24.57	52	22260	33400	110533587
Conjunctival erosion	58.97	24.57	13	22299	242	110566745
Optical coherence tomography abnormal	58.91	24.57	12	22300	150	110566837
Alopecia	58.05	24.57	4	22308	364749	110202238
Drug intolerance	57.92	24.57	7	22305	406505	110160482
Subretinal haematoma	57.69	24.57	10	22302	47	110566940
Maculopathy	57.47	24.57	22	22290	3005	110563982
Tachyphylaxis	57.10	24.57	14	22298	421	110566566
Vitreous haze	55.97	24.57	11	22301	113	110566874
Abdominal pain	55.96	24.57	17	22295	512972	110054015
Decreased appetite	55.20	24.57	14	22298	475832	110091155
Cataract subcapsular	54.70	24.57	17	22295	1244	110565743
Iritis	51.52	24.57	23	22289	4629	110562358
Hypotony of eye	50.93	24.57	13	22299	462	110566525
Staphylococcus test positive	49.90	24.57	26	22286	7344	110559643
Vitreous adhesions	49.39	24.57	9	22303	59	110566928
Suspected transmission of an infectious agent via product	48.88	24.57	16	22296	1384	110565603
Retinal drusen	48.27	24.57	9	22303	68	110566919
Retinal vascular occlusion	47.33	24.57	13	22299	615	110566372
Pain	47.22	24.57	75	22237	954880	109612107
Diabetic retinal oedema	46.86	24.57	12	22300	432	110566555
Abdominal discomfort	46.82	24.57	11	22301	393847	110173140
Hypotension	46.26	24.57	24	22288	523825	110043162
Rheumatoid arthritis	45.66	24.57	4	22308	299609	110267378
Visual acuity reduced transiently	45.59	24.57	11	22301	309	110566678
Detachment of macular retinal pigment epithelium	45.57	24.57	7	22305	12	110566975
Vitreous degeneration	45.42	24.57	8	22304	42	110566945
Pruritus	45.24	24.57	31	22281	581529	109985458
Retinal pallor	45.05	24.57	6	22306	0	110566987
Retinal pigment epitheliopathy	44.76	24.57	12	22300	518	110566469
Ocular vascular disorder	44.51	24.57	13	22299	769	110566218
Conjunctival retraction	43.83	24.57	8	22304	53	110566934
Aphonia	43.61	24.57	29	22283	12831	110554156
Stomatitis	42.88	24.57	3	22309	270239	110296748
Angina pectoris	41.79	24.57	57	22255	62238	110504749
Inappropriate schedule of product administration	41.52	24.57	112	22200	203525	110363462
Iris neovascularisation	40.72	24.57	8	22304	82	110566905
Pseudoendophthalmitis	40.72	24.57	8	22304	82	110566905
Eye infection	40.43	24.57	29	22283	14489	110552498
Pain in extremity	39.18	24.57	25	22287	487093	110079894
Macular pigmentation	38.46	24.57	6	22306	12	110566975
Macular detachment	37.50	24.57	9	22303	247	110566740
Retinal occlusive vasculitis	37.46	24.57	9	22303	248	110566739
Fundoscopy abnormal	36.97	24.57	7	22305	58	110566929
Vitrectomy	36.83	24.57	9	22303	267	110566720
Retinal fibrosis	36.74	24.57	6	22306	18	110566969
Retinal injury	36.49	24.57	10	22302	469	110566518
Peripheral swelling	36.42	24.57	18	22294	404016	110162971
Wound	36.07	24.57	3	22309	234434	110332553
Arthralgia	35.94	24.57	64	22248	779568	109787419
Acute myocardial infarction	35.53	24.57	62	22250	83715	110483272
Drug resistance	35.44	24.57	50	22262	56324	110510663
Posterior capsule rupture	35.40	24.57	6	22306	24	110566963
Conjunctival hyperaemia	35.04	24.57	19	22293	5812	110561175
Vitreal cells	35.02	24.57	8	22304	176	110566811
Haemorrhagic stroke	34.90	24.57	26	22286	13763	110553224
Dysphonia	34.58	24.57	58	22254	75871	110491116
Choroidal effusion	34.45	24.57	11	22301	879	110566108
Neovascularisation	34.33	24.57	13	22299	1724	110565263
Arthropathy	34.22	24.57	8	22304	287514	110279473
Thrombocytopenia	33.85	24.57	14	22298	348871	110218116
Foreign body in eye	33.62	24.57	9	22303	386	110566601
Chorioretinal scar	33.56	24.57	7	22305	99	110566888
Macular thickening	33.24	24.57	6	22306	37	110566950
Anaemia	33.06	24.57	37	22275	547049	110019938
Dyspnoea	32.93	24.57	114	22198	1106758	109460229
Conjunctival disorder	32.82	24.57	9	22303	423	110566564
Wheezing	32.64	24.57	6	22306	255224	110311763
Insomnia	32.59	24.57	16	22296	360574	110206413
Corneal disorder	32.52	24.57	14	22298	2583	110564404
Weight decreased	32.49	24.57	28	22284	468029	110098958
Myocardial ischaemia	32.23	24.57	33	22279	26651	110540336
Blister	32.16	24.57	4	22308	227372	110339615
Sinusitis	32.02	24.57	10	22302	296678	110270309
Dry eye	31.46	24.57	47	22265	55746	110511241
Swelling	31.09	24.57	16	22296	351025	110215962
Blepharitis	30.65	24.57	16	22296	4536	110562451
Pericarditis	30.63	24.57	4	22308	219110	110347877
Somnolence	30.40	24.57	11	22301	297438	110269549
Open angle glaucoma	30.30	24.57	9	22303	565	110566422
Anterior chamber disorder	30.22	24.57	7	22305	164	110566823
Sudden visual loss	29.38	24.57	6	22306	76	110566911
Nasopharyngitis	29.36	24.57	22	22290	394339	110172648
Drug hypersensitivity	29.35	24.57	29	22283	454061	110112926
Musculoskeletal stiffness	29.20	24.57	10	22302	279812	110287175
Concomitant disease aggravated	28.92	24.57	25	22287	16339	110550648
COVID-19	28.80	24.57	7	22305	245053	110321934
Intra-ocular injection complication	28.44	24.57	6	22306	90	110566897
Aneurysm	28.15	24.57	15	22297	4431	110562556
IIIrd nerve paresis	28.13	24.57	7	22305	224	110566763
Abnormal sensation in eye	28.09	24.57	12	22300	2174	110564813
Constipation	27.89	24.57	19	22293	357767	110209220
Corneal lesion	27.68	24.57	6	22306	103	110566884
Choroidal detachment	27.67	24.57	9	22303	763	110566224
Oedema peripheral	27.62	24.57	16	22296	328644	110238343
Giant cell arteritis	27.62	24.57	14	22298	3735	110563252
Intraocular lens implant	27.61	24.57	8	22304	460	110566527
Retinal perivascular sheathing	27.36	24.57	6	22306	109	110566878
Muscle spasms	27.24	24.57	11	22301	278146	110288841
Dry mouth	27.13	24.57	4	22308	199944	110367043
Asthenia	27.08	24.57	62	22250	688937	109878050
Corneal opacity	27.05	24.57	10	22302	1241	110565746
Asthenopia	26.82	24.57	13	22299	3151	110563836
Acute kidney injury	26.78	24.57	55	22257	635375	109931612
Pancytopenia	26.65	24.57	5	22307	209608	110357379
Tractional retinal detachment	26.58	24.57	6	22306	125	110566862
Psoriatic arthropathy	26.55	24.57	4	22308	196757	110370230
Cerebral haemorrhage	26.15	24.57	47	22265	64921	110502066
White blood cell count decreased	26.09	24.57	7	22305	229383	110337604
Angle closure glaucoma	25.58	24.57	13	22299	3486	110563501
Bacterial endophthalmitis	25.41	24.57	7	22305	335	110566652
Cataract cortical	25.35	24.57	6	22306	155	110566832
Overdose	25.01	24.57	8	22304	233786	110333201
Normal tension glaucoma	24.73	24.57	5	22307	60	110566927
Charles Bonnet syndrome	24.73	24.57	5	22307	60	110566927

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	S01LA04	SENSORY ORGANS OPHTHALMOLOGICALS OCULAR VASCULAR DISORDER AGENTS Antineovascularisation agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D006131	Growth Inhibitors
MeSH PA	D006133	Growth Substances
MeSH PA	D020533	Angiogenesis Inhibitors
FDA MoA	N0000193542	Vascular Endothelial Growth Factor Inhibitors
FDA EPC	N0000193543	Vascular Endothelial Growth Factor Inhibitor
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:39456	antiglaucoma drug
CHEBI has role	CHEBI:66981	ophthalmology drug

Related Drugs by ATC class:

S01LA Antineovascularisation agents 7 drugs

afliberceptanecortavebevacizumabbrolucizumabfaricimabpegaptanibverteporfin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetic retinopathy	indication	4855003	DOID:8947
Choroidal retinal neovascularization	indication	75971007
Central retinal vein occlusion with macular edema	indication	232039004
Branch retinal vein occlusion with macular edema	indication	232048009
Age related macular degeneration	indication	267718000	DOID:10871
Macular edema due to diabetes mellitus	indication	312912001	DOID:9191
Exudative age-related macular degeneration	indication	414173003	DOID:10873
Retinopathy of prematurity	indication	415297005	DOID:13025
Eye infection	contraindication	128351009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Vascular endothelial growth factor A	Secreted	P15692	VEGFA_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D05697	KEGG_DRUG
4025260	VUID
N0000179788	NUI
4025260	VANDF
4041511	VANDF
CHEBI:749601	CHEBI
CHEMBL1201825	ChEMBL_ID
C000719192	MESH_SUPPLEMENTAL_RECORD_UI
6779	IUPHAR_LIGAND_ID
DB01270	DRUGBANK_ID
2602351	RXNORM
21678	MMSL
350639	MMSL
39922	MMSL
83454	MMSL
011622	NDDF
018852	NDDF
422456007	SNOMEDCT_US
425256004	SNOMEDCT_US
C1566537	UMLSCUI
D000069579	MESH_DESCRIPTOR_UI
8313	INN_ID
ZL1R02VT79	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Susvimo	HUMAN PRESCRIPTION DRUG LABEL	1	50242-078	INJECTION, SOLUTION	100 mg	INTRAVITREAL	BLA	30 sections
LUCENTIS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-080	INJECTION, SOLUTION	10 mg	INTRAVITREAL	BLA	28 sections
LUCENTIS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-082	INJECTION, SOLUTION	6 mg	INTRAVITREAL	BLA	28 sections
CIMERLI	HUMAN PRESCRIPTION DRUG LABEL	1	61314-624	INJECTION, SOLUTION	0.30 mg	INTRAVITREAL	BLA	29 sections
CIMERLI	HUMAN PRESCRIPTION DRUG LABEL	1	61314-625	INJECTION, SOLUTION	0.50 mg	INTRAVITREAL	BLA	29 sections
Byooviz	HUMAN PRESCRIPTION DRUG LABEL	1	64406-019	INJECTION, SOLUTION	10 mg	INTRAVITREAL	BLA	31 sections
CIMERLI	HUMAN PRESCRIPTION DRUG LABEL	1	70114-440	INJECTION, SOLUTION	0.30 mg	INTRAVITREAL	BLA	31 sections
CIMERLI	HUMAN PRESCRIPTION DRUG LABEL	1	70114-441	INJECTION, SOLUTION	0.50 mg	INTRAVITREAL	BLA	31 sections
NUFYMCO	HUMAN PRESCRIPTION DRUG LABEL	1	70710-2172	INJECTION, SOLUTION	0.30 mg	INTRAVITREAL	BLA	24 sections
NUFYMCO	HUMAN PRESCRIPTION DRUG LABEL	1	70710-2173	INJECTION, SOLUTION	0.50 mg	INTRAVITREAL	BLA	24 sections
Byooviz	HUMAN PRESCRIPTION DRUG LABEL	1	82667-018	INJECTION, SOLUTION	10 mg	INTRAVITREAL	BLA	31 sections