pegaptanib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
aptamers, classical and mirror ones	4905	222716-86-1

Description:

Molecule	Description
Synonyms: pegaptanib pegaptanib sodium macugen pegaptanib octasodium EYE001 NX1838	a pegylated modified oligonucleotide that binds with high specificity and affinity to extracellular Vascular Endothelial Growth Factor (VEGF165) inhibiting its activity, VEGF is a secreted protein that induces angiogenesis, vascular permeability and inflammation, all of which are thought to contribute to the progression of the neovascular (wet) form of AMD Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

pegaptanib
pegaptanib sodium
macugen
pegaptanib octasodium
EYE001
NX1838

a pegylated modified oligonucleotide that binds with high specificity and affinity to extracellular Vascular Endothelial Growth Factor (VEGF165) inhibiting its activity, VEGF is a secreted protein that induces angiogenesis, vascular permeability and inflammation, all of which are thought to contribute to the progression of the neovascular (wet) form of AMD

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Dec. 17, 2004	FDA	VALEANT PHARMS LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	S01LA03	SENSORY ORGANS OPHTHALMOLOGICALS OCULAR VASCULAR DISORDER AGENTS Antineovascularisation agents
FDA CS	M0015278	Oligonucleotides
FDA CS	M0483498	Aptamers, Nucleotide

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Exudative age-related macular degeneration	indication	414173003	DOID:10873

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Vascular endothelial growth factor A	Secreted	P15692	VEGFA_HUMAN	ANTAGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D05386	KEGG_DRUG
4024940	VUID
N0000171612	NUI
4024940	VANDF
CHEMBL2108752	ChEMBL_ID
C495058	MESH_SUPPLEMENTAL_RECORD_UI
C430291	MESH_SUPPLEMENTAL_RECORD_UI
6836	IUPHAR_LIGAND_ID
DB04895	DRUGBANK_ID
498509	RXNORM
19106	MMSL
64008	MMSL
008794	NDDF
008795	NDDF
416058004	SNOMEDCT_US
416268001	SNOMEDCT_US
423490007	SNOMEDCT_US
C1531015	UMLSCUI
CHEMBL1201421	ChEMBL_ID
8215	INN_ID
56603655	PUBCHEM_CID
2H1PA8H1EN	UNII

Pharmaceutical products:

None