bevacizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4956 216974-75-3

Description:

MoleculeDescription

Synonyms:

  • bevacizumab-awwb
  • mvasi
  • bevacizumab
  • avastin
  • rhuMAb-VEGF
  • bevacituzumab
  • bevacizumab (genetical recombination)
  • bevacizumab biosimilar 3
An anti-VEGF humanized murine monoclonal antibody. It inhibits VEGF RECEPTORS and helps to prevent PATHOLOGIC ANGIOGENESIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 18, 2007 PMDA Chugai Pharmaceutical
Feb. 26, 2004 FDA GENENTECH
Dec. 1, 2005 EMA Roche Registration Limited

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 2837.14 12.85 3544 109346 321835 50170399
Disease progression 2807.93 12.85 2048 110842 93818 50398416
Proteinuria 1376.04 12.85 693 112197 15904 50476330
Hypertension 1131.14 12.85 1829 111061 209374 50282860
Gastrointestinal perforation 1062.89 12.85 357 112533 2704 50489530
Off label use 714.89 12.85 2498 110392 471928 50020306
Palmar-plantar erythrodysaesthesia syndrome 698.92 12.85 478 112412 19620 50472614
Neutrophil count decreased 659.08 12.85 653 112237 45373 50446861
Endophthalmitis 614.68 12.85 235 112655 2681 50489553
Malignant neoplasm progression 610.48 12.85 756 112134 67368 50424866
Neutropenia 589.84 12.85 1127 111763 146838 50345396
Intestinal perforation 564.77 12.85 329 112561 10150 50482084
Epistaxis 516.45 12.85 674 112216 63280 50428954
Drug ineffective 474.37 12.85 687 112203 818646 49673588
Bone marrow failure 465.66 12.85 429 112461 27195 50465039
Anaemia 443.02 12.85 1402 111488 251054 50241180
Large intestine perforation 440.50 12.85 249 112641 7245 50484989
Ascites 430.55 12.85 463 112427 35398 50456836
Metastases to liver 416.45 12.85 351 112539 19753 50472481
Mucosal inflammation 416.15 12.85 480 112410 39662 50452572
Joint swelling 414.38 12.85 36 112854 245250 50246984
Neuropathy peripheral 395.01 12.85 745 112145 96012 50396222
Rheumatoid arthritis 393.58 12.85 13 112877 202537 50289697
Posterior reversible encephalopathy syndrome 386.49 12.85 297 112593 14631 50477603
Myelosuppression 339.18 12.85 264 112626 13253 50478981
Febrile neutropenia 332.41 12.85 697 112193 96970 50395264
Metastases to lung 327.09 12.85 238 112652 10782 50481452
Thrombocytopenia 323.70 12.85 811 112079 126862 50365372
Arthropathy 307.16 12.85 10 112880 157896 50334338
Contraindicated product administered 306.79 12.85 5 112885 148953 50343281
Maternal exposure during pregnancy 294.43 12.85 15 112875 159763 50332471
Peripheral sensory neuropathy 293.25 12.85 183 112707 6408 50485826
Systemic lupus erythematosus 284.38 12.85 6 112884 140616 50351618
Peritonitis 275.59 12.85 248 112642 15238 50476996
Completed suicide 273.40 12.85 4 112886 131885 50360349
Metastases to bone 266.10 12.85 260 112630 17735 50474499
Platelet count decreased 265.94 12.85 650 112240 100076 50392158
Suspected transmission of an infectious agent via product 261.97 12.85 68 112822 172 50492062
Synovitis 260.08 12.85 3 112887 123862 50368372
Product dose omission issue 259.72 12.85 48 112842 183790 50308444
Intestinal obstruction 257.57 12.85 306 112584 26077 50466157
Metastases to central nervous system 250.29 12.85 205 112685 11077 50481157
Therapeutic product effect decreased 232.21 12.85 19 112871 136031 50356203
Small intestinal obstruction 231.70 12.85 229 112661 15839 50476395
Neurotoxicity 227.40 12.85 218 112672 14522 50477712
Detachment of retinal pigment epithelium 226.36 12.85 66 112824 291 50491943
Visual acuity reduced 224.22 12.85 250 112640 19889 50472345
Drug hypersensitivity 223.90 12.85 142 112748 250868 50241366
Exposure during pregnancy 220.90 12.85 12 112878 121003 50371231
Peripheral swelling 220.05 12.85 92 112798 205844 50286390
Abdominal pain 215.41 12.85 1069 111821 235159 50257075
Drug interaction 213.58 12.85 89 112801 199532 50292702
Condition aggravated 209.96 12.85 212 112678 296846 50195388
Pulmonary embolism 209.05 12.85 598 112292 101106 50391128
Polyneuropathy 207.47 12.85 190 112700 11941 50480293
Age-related macular degeneration 200.24 12.85 69 112821 569 50491665
Swelling 198.66 12.85 100 112790 200772 50291462
Macular oedema 197.58 12.85 115 112775 3539 50488695
Osteonecrosis of jaw 195.77 12.85 298 112592 32228 50460006
Female genital tract fistula 194.59 12.85 114 112776 3552 50488682
Sinusitis 189.04 12.85 72 112818 170486 50321748
Drug intolerance 188.51 12.85 129 112761 218975 50273259
Glossodynia 186.93 12.85 20 112870 115549 50376685
White blood cell count decreased 185.87 12.85 628 112262 116094 50376140
Small intestinal perforation 178.53 12.85 77 112813 1221 50491013
General physical health deterioration 178.48 12.85 709 112181 141725 50350509
Ileus 173.28 12.85 179 112711 13050 50479184
Injection site pain 172.64 12.85 22 112868 111002 50381232
Intentional product use issue 170.55 12.85 465 112425 76453 50415781
Leukopenia 169.91 12.85 428 112462 67100 50425134
Abdominal discomfort 169.73 12.85 160 112730 231481 50260753
Metastases to peritoneum 168.82 12.85 95 112795 2738 50489496
Embolism 168.11 12.85 133 112757 6835 50485399
Vomiting 167.78 12.85 1665 111225 459093 50033141
Vitreous floaters 167.37 12.85 119 112771 5195 50487039
Arthralgia 167.31 12.85 467 112423 438235 50053999
Pleural effusion 165.46 12.85 477 112413 80977 50411257
Tumour necrosis 164.96 12.85 62 112828 672 50491562
Metastases to meninges 164.05 12.85 83 112807 1919 50490315
Musculoskeletal stiffness 160.42 12.85 44 112846 128437 50363797
Decreased appetite 160.03 12.85 876 112014 200047 50292187
Pain 158.79 12.85 709 112181 578194 49914040
Pruritus 157.77 12.85 243 112647 283325 50208909
Weight increased 156.83 12.85 132 112758 201759 50290475
Retinal haemorrhage 154.56 12.85 107 112783 4474 50487760
Diarrhoea 153.50 12.85 1992 110898 586484 49905750
Dehydration 153.30 12.85 710 112180 151739 50340495
Pneumothorax 149.03 12.85 170 112720 13864 50478370
Wound dehiscence 148.12 12.85 102 112788 4228 50488006
Treatment failure 144.52 12.85 63 112827 137574 50354660
Photopsia 144.16 12.85 97 112793 3869 50488365
Protein urine 142.30 12.85 53 112837 559 50491675
Nephrotic syndrome 139.23 12.85 102 112788 4668 50487566
Blindness 139.21 12.85 182 112708 17087 50475147
Hepatic enzyme increased 137.85 12.85 67 112823 137313 50354921
Fistula 137.19 12.85 127 112763 8091 50484143
Hepatic atrophy 135.98 12.85 42 112848 234 50492000
Cystoid macular oedema 135.50 12.85 65 112825 1334 50490900
Nasal septum perforation 135.45 12.85 53 112837 646 50491588
Psoriasis 135.42 12.85 4 112886 68996 50423238
Injection site erythema 134.96 12.85 8 112882 74928 50417306
Rectal perforation 134.01 12.85 45 112845 340 50491894
Fall 130.93 12.85 352 112538 334580 50157654
Rash 128.21 12.85 522 112368 436949 50055285
Neoplasm progression 128.20 12.85 232 112658 28925 50463309
Thrombotic microangiopathy 126.19 12.85 125 112765 8666 50483568
Glomerular vascular disorder 126.01 12.85 27 112863 15 50492219
Retinal pigment epithelial tear 119.36 12.85 37 112853 209 50492025
Asthma 118.45 12.85 27 112863 89310 50402924
Haematotoxicity 118.43 12.85 115 112775 7780 50484454
Nausea 117.73 12.85 2215 110675 703183 49789051
Wound 114.95 12.85 46 112844 105748 50386486
Lower respiratory tract infection 114.41 12.85 35 112855 95166 50397068
Ovarian cancer recurrent 113.74 12.85 50 112840 832 50491402
Subileus 108.80 12.85 71 112819 2688 50489546
Carbohydrate antigen 125 increased 108.48 12.85 68 112822 2399 50489835
Pericarditis 105.90 12.85 23 112867 78666 50413568
Deep vein thrombosis 105.84 12.85 382 112508 72922 50419312
Hydronephrosis 105.47 12.85 112 112778 8429 50483805
Portal hypertension 104.62 12.85 75 112815 3317 50488917
Toxicity to various agents 104.40 12.85 197 112693 212302 50279932
Overdose 104.11 12.85 46 112844 99681 50392553
Constipation 101.14 12.85 735 112155 184973 50307261
Eye discharge 101.05 12.85 87 112803 5036 50487198
Uveitis 99.22 12.85 113 112777 9197 50483037
Tumour haemorrhage 98.98 12.85 52 112838 1303 50490931
Feeling abnormal 98.67 12.85 81 112809 125411 50366823
Eye haemorrhage 97.41 12.85 100 112790 7235 50484999
Insomnia 96.98 12.85 150 112740 174715 50317519
Urticaria 96.56 12.85 88 112802 129473 50362761
Nasopharyngitis 96.40 12.85 177 112713 192750 50299484
Hypertensive crisis 95.88 12.85 132 112758 13022 50479212
Hospitalisation 95.28 12.85 18 112872 67919 50424315
Loss of personal independence in daily activities 95.23 12.85 20 112870 70030 50422204
Carcinoembryonic antigen increased 94.87 12.85 52 112838 1422 50490812
Urogenital fistula 94.30 12.85 27 112863 110 50492124
Suicidal ideation 93.71 12.85 8 112882 55377 50436857
Helicobacter infection 93.64 12.85 4 112886 49698 50442536
Protein urine present 91.51 12.85 84 112806 5293 50486941
Dysphonia 91.06 12.85 240 112650 38652 50453582
Metastases to lymph nodes 90.11 12.85 94 112796 6930 50485304
Somnolence 89.77 12.85 129 112761 154856 50337378
Vitritis 88.53 12.85 42 112848 840 50491394
Blister 86.66 12.85 41 112849 85377 50406857
Hepatic failure 85.78 12.85 209 112681 32074 50460160
Metastasis 85.69 12.85 74 112816 4301 50487933
Metamorphopsia 84.69 12.85 42 112848 929 50491305
Gastric perforation 84.10 12.85 48 112842 1422 50490812
Aortic dissection 82.85 12.85 49 112841 1554 50490680
Vitreous detachment 82.81 12.85 51 112839 1743 50490491
Malignant pleural effusion 82.33 12.85 56 112834 2274 50489960
Irritable bowel syndrome 80.40 12.85 10 112880 51431 50440803
Discomfort 79.11 12.85 75 112815 108305 50383929
Blood cholesterol increased 78.78 12.85 14 112876 55201 50437033
Arthritis 78.65 12.85 48 112842 86673 50405561
Suicide attempt 78.60 12.85 11 112879 51721 50440513
Intentional product misuse 78.39 12.85 7 112883 46727 50445507
Dizziness 77.71 12.85 454 112436 345915 50146319
Ejection fraction decreased 77.16 12.85 144 112746 18376 50473858
Mobility decreased 77.16 12.85 41 112849 79907 50412327
Depression 75.51 12.85 160 112730 165263 50326971
Injury 75.29 12.85 10 112880 48915 50443319
Influenza 75.20 12.85 54 112836 89484 50402750
Injection site reaction 75.17 12.85 11 112879 50021 50442213
Enterocutaneous fistula 74.08 12.85 41 112849 1143 50491091
Cataract nuclear 73.90 12.85 37 112853 836 50491398
Hypomagnesaemia 73.73 12.85 161 112729 22995 50469239
Pain in extremity 72.78 12.85 337 112553 272528 50219706
Osteonecrosis 72.20 12.85 157 112733 22360 50469874
Gastrointestinal toxicity 71.80 12.85 69 112821 4608 50487626
Oesophagitis 71.33 12.85 116 112774 13267 50478967
Injection site pruritus 70.72 12.85 5 112885 40406 50451828
Fibromyalgia 69.67 12.85 9 112881 44969 50447265
Gait disturbance 69.37 12.85 144 112746 149861 50342373
Inappropriate schedule of product administration 69.08 12.85 37 112853 71794 50420440
Therapy partial responder 68.55 12.85 79 112811 6512 50485722
Duodenal perforation 68.31 12.85 33 112857 688 50491546
Bronchitis 67.16 12.85 80 112810 104079 50388155
Retinal oedema 67.12 12.85 31 112859 582 50491652
Wrong technique in product usage process 63.86 12.85 22 112868 55488 50436746
Tumour perforation 63.72 12.85 19 112871 92 50492142
Hypophosphataemia 63.69 12.85 86 112804 8328 50483906
Stomatitis 62.09 12.85 413 112477 100931 50391303
Neoplasm 61.56 12.85 71 112819 5857 50486377
Palpitations 61.56 12.85 72 112818 94434 50397800
Contusion 61.43 12.85 97 112793 112086 50380148
Lymphangiosis carcinomatosa 60.35 12.85 36 112854 1160 50491074
Left ventricular dysfunction 60.02 12.85 94 112796 10412 50481822
Duodenal ulcer perforation 60.02 12.85 14 112876 45597 50446637
Tumour marker increased 59.60 12.85 57 112833 3783 50488451
Osteoarthritis 59.43 12.85 40 112850 68566 50423668
Abortion spontaneous 58.71 12.85 11 112879 41761 50450473
Cerebral ischaemia 58.42 12.85 69 112821 5839 50486395
Retinal exudates 57.77 12.85 29 112861 659 50491575
Therapeutic product effect incomplete 57.19 12.85 72 112818 91443 50400791
Pseudocirrhosis 57.18 12.85 28 112862 602 50491632
Asthenia 57.06 12.85 1014 111876 318028 50174206
Vitreous haemorrhage 57.03 12.85 40 112850 1708 50490526
Skin toxicity 56.83 12.85 56 112834 3857 50488377
Eye pruritus 56.70 12.85 101 112789 12433 50479801
Injection site bruising 55.43 12.85 8 112882 36760 50455474
Haemoglobin 55.42 12.85 19 112871 154 50492080
Leukoencephalopathy 55.33 12.85 55 112835 3828 50488406
Enteritis 55.25 12.85 73 112817 6922 50485312
Dermatitis acneiform 55.12 12.85 56 112834 4001 50488233
Haemoptysis 55.03 12.85 153 112737 25420 50466814
Macular ischaemia 54.33 12.85 13 112877 20 50492214
Incorrect dose administered 54.31 12.85 20 112870 48394 50443840
Stress 54.28 12.85 26 112864 53767 50438467
Tumour ulceration 54.07 12.85 18 112872 132 50492102
Product use issue 53.91 12.85 163 112727 149312 50342922
Hepatic function abnormal 53.84 12.85 178 112712 32503 50459731
Hypokalaemia 53.54 12.85 358 112532 87634 50404600
Ileal perforation 53.25 12.85 23 112867 366 50491868
Osteoporosis 53.00 12.85 17 112873 44862 50447372
Venous thrombosis limb 52.67 12.85 45 112845 2577 50489657
Malignant ascites 51.90 12.85 29 112861 824 50491410
Laryngospasm 51.70 12.85 45 112845 2643 50489591
Folliculitis 51.69 12.85 12 112878 39213 50453021
Eye inflammation 51.64 12.85 55 112835 4153 50488081
Dry throat 51.58 12.85 63 112827 5521 50486713
Lymphocele 51.14 12.85 28 112862 764 50491470
Headache 51.11 12.85 809 112081 505726 49986508
Type 2 diabetes mellitus 50.62 12.85 8 112882 34367 50457867
Red blood cell sedimentation rate increased 50.45 12.85 4 112886 29412 50462822
Wheezing 50.06 12.85 39 112851 62008 50430226
Disseminated intravascular coagulation 49.92 12.85 115 112775 17020 50475214
Pneumonia 49.86 12.85 572 112318 377829 50114405
Retinal detachment 49.23 12.85 59 112831 5070 50487164
Cardiomyopathy 49.20 12.85 108 112782 15478 50476756
Superior vena cava syndrome 49.13 12.85 25 112865 585 50491649
Retinal disorder 48.66 12.85 34 112856 1443 50490791
Perforation 48.60 12.85 29 112861 935 50491299
Abdominal abscess 48.50 12.85 52 112838 3956 50488278
Throat tightness 48.13 12.85 128 112762 20719 50471515
Adverse drug reaction 48.09 12.85 32 112858 55190 50437044
Electrocardiogram QT prolonged 48.04 12.85 28 112862 51858 50440376
Metastases to pleura 47.60 12.85 32 112858 1274 50490960
Retinal degeneration 47.30 12.85 26 112864 715 50491519
Peritoneal disorder 47.02 12.85 22 112868 426 50491808
Bradycardia 46.51 12.85 45 112845 64381 50427853
Chronic obstructive pulmonary disease 46.49 12.85 31 112859 53404 50438830
Pantoea agglomerans infection 46.33 12.85 12 112878 30 50492204
Drug reaction with eosinophilia and systemic symptoms 45.72 12.85 5 112885 28419 50463815
Neutropenic infection 45.39 12.85 29 112861 1058 50491176
Pneumonitis 45.33 12.85 157 112733 29353 50462881
Anxiety 45.17 12.85 223 112667 177383 50314851
Anal fistula 45.04 12.85 42 112848 2700 50489534
Laryngeal necrosis 44.68 12.85 10 112880 9 50492225
Metastatic neoplasm 44.19 12.85 48 112842 3706 50488528
Pyrexia 44.18 12.85 1135 111755 379068 50113166
Subretinal fluid 44.12 12.85 20 112870 359 50491875
Visual impairment 44.10 12.85 282 112608 67993 50424241
Mucosal toxicity 43.95 12.85 19 112871 303 50491931
COVID-19 43.46 12.85 25 112865 46637 50445597
Irritability 43.28 12.85 6 112884 28420 50463814
Infusion related reaction 43.05 12.85 213 112677 169344 50322890
Gastrointestinal fistula 42.80 12.85 20 112870 386 50491848
Bladder tamponade 42.77 12.85 13 112877 68 50492166
Pulmonary haemorrhage 42.65 12.85 62 112828 6430 50485804
Tumour rupture 42.61 12.85 14 112876 98 50492136
Pelvic abscess 42.53 12.85 31 112859 1407 50490827
Lactic acidosis 42.40 12.85 11 112879 33344 50458890
Acute abdomen 42.19 12.85 31 112859 1425 50490809
Retinal vascular disorder 42.12 12.85 16 112874 179 50492055
Ciliary hyperaemia 42.00 12.85 9 112881 5 50492229
Diabetes mellitus 41.91 12.85 29 112861 49004 50443230
Acute myeloid leukaemia 41.55 12.85 99 112791 14975 50477259
Drug withdrawal syndrome 41.41 12.85 4 112886 25077 50467157
Migraine 41.29 12.85 65 112825 75215 50417019
Agitation 41.26 12.85 35 112855 53349 50438885
Hemiparesis 41.23 12.85 118 112772 19930 50472304
No adverse event 41.04 12.85 166 112724 33412 50458822
Muscle spasms 41.04 12.85 143 112747 125410 50366824
Therapy cessation 40.78 12.85 5 112885 26006 50466228
Rhabdomyolysis 40.71 12.85 18 112872 39009 50453225
Device related infection 40.68 12.85 120 112770 20615 50471619
Colitis 40.53 12.85 182 112708 38347 50453887
Illness 40.29 12.85 4 112886 24536 50467698
Malignant glioma 40.26 12.85 9 112881 8 50492226
Treatment noncompliance 40.17 12.85 9 112881 30141 50462093
Onycholysis 40.12 12.85 29 112861 1299 50490935
Cystitis radiation 39.93 12.85 12 112878 60 50492174
Radiation necrosis 39.61 12.85 18 112872 325 50491909
Fluid retention 39.40 12.85 33 112857 50616 50441618
Anastomotic leak 39.29 12.85 19 112871 397 50491837
Transmission of an infectious agent via product 39.17 12.85 14 112876 130 50492104
Fistula of small intestine 39.10 12.85 17 112873 275 50491959
Sedation 39.09 12.85 10 112880 30600 50461634
Sepsis 39.07 12.85 461 112429 132464 50359770
Venous thrombosis 39.03 12.85 49 112841 4417 50487817
Retinal scar 38.89 12.85 14 112876 133 50492101
Red cell distribution width increased 38.75 12.85 69 112821 8490 50483744
Portal vein thrombosis 38.51 12.85 35 112855 2177 50490057
Bacterial endophthalmitis 38.37 12.85 9 112881 12 50492222
Interstitial lung disease 38.35 12.85 226 112664 52950 50439284
Mechanical ileus 38.34 12.85 17 112873 289 50491945
Macular scar 38.07 12.85 13 112877 104 50492130
Hallucination 38.05 12.85 29 112861 46628 50445606
Dyskinesia 37.76 12.85 8 112882 27853 50464381
Large intestinal obstruction 37.69 12.85 32 112858 1817 50490417
Joint injury 37.26 12.85 3 112887 21786 50470448
Gastric disorder 37.07 12.85 10 112880 29538 50462696
Neutrophil count 36.91 12.85 16 112874 257 50491977
Sleep disorder 36.91 12.85 44 112846 57239 50434995
Pneumoperitoneum 36.73 12.85 27 112863 1242 50490992
Nail toxicity 36.62 12.85 17 112873 323 50491911
Paronychia 36.62 12.85 48 112842 4516 50487718
Tracheal fistula 36.56 12.85 10 112880 33 50492201
Haematuria 36.53 12.85 133 112757 25480 50466754
Blood bilirubin increased 36.49 12.85 155 112735 31883 50460351
Ear infection 36.15 12.85 7 112883 25963 50466271
Proctalgia 36.15 12.85 50 112840 4953 50487281
Memory impairment 35.97 12.85 77 112813 79283 50412951
Adverse event 35.95 12.85 27 112863 43736 50448498
Ovarian cancer metastatic 35.93 12.85 22 112868 744 50491490
Enterovesical fistula 35.92 12.85 19 112871 483 50491751
Gastrointestinal anastomotic leak 35.90 12.85 14 112876 169 50492065
Metabolic acidosis 35.88 12.85 21 112869 38804 50453430
Product prescribing error 35.53 12.85 3 112887 20958 50471276
Tremor 35.48 12.85 134 112756 114769 50377465
Cardiac failure 35.21 12.85 290 112600 75750 50416484
Upper respiratory tract infection 35.10 12.85 58 112832 65840 50426394
Sudden death 35.09 12.85 68 112822 8923 50483311
Vitreous opacities 34.71 12.85 15 112875 239 50491995
Macular fibrosis 34.70 12.85 17 112873 366 50491868
Suspected counterfeit product 34.57 12.85 16 112874 302 50491932
Abdominal infection 34.36 12.85 29 112861 1633 50490601
Eastern Cooperative Oncology Group performance status worsened 34.28 12.85 20 112870 618 50491616
Hypoalbuminaemia 34.21 12.85 71 112819 9789 50482445
Peripheral motor neuropathy 33.84 12.85 27 112863 1404 50490830
Intraocular pressure increased 33.82 12.85 51 112839 5465 50486769
Lymphocyte count decreased 33.71 12.85 132 112758 26175 50466059
Choroiditis 33.61 12.85 12 112878 111 50492123
Neutrophil count abnormal 33.51 12.85 34 112856 2425 50489809
Hypertensive encephalopathy 33.22 12.85 19 112871 565 50491669
Metastases to ovary 33.10 12.85 16 112874 334 50491900
Retinal artery occlusion 32.93 12.85 27 112863 1460 50490774
Hypersensitivity 32.86 12.85 314 112576 214847 50277387
Hypotension 32.11 12.85 353 112537 235116 50257118
Pseudoendophthalmitis 32.11 12.85 8 112882 16 50492218
Multiple sclerosis 31.98 12.85 4 112886 20489 50471745
Cholangitis 31.95 12.85 45 112845 4534 50487700
Foot deformity 31.88 12.85 3 112887 19207 50473027
Pregnancy 31.88 12.85 13 112877 29564 50462670
Breast cancer metastatic 31.79 12.85 71 112819 10293 50481941
Stoma site haemorrhage 31.79 12.85 22 112868 919 50491315
Venous pressure jugular decreased 31.76 12.85 9 112881 35 50492199
Retinal neovascularisation 31.76 12.85 9 112881 35 50492199
Haemolytic uraemic syndrome 31.49 12.85 32 112858 2287 50489947
Aortoenteric fistula 31.43 12.85 7 112883 6 50492228
Atypical haemolytic uraemic syndrome 31.36 12.85 18 112872 539 50491695
Therapy interrupted 31.29 12.85 4 112886 20148 50472086
Urinary tract obstruction 31.10 12.85 28 112862 1720 50490514
Device issue 30.92 12.85 4 112886 19968 50472266
Vaginal fistula 30.89 12.85 16 112874 389 50491845
Hypopyon 30.83 12.85 19 112871 650 50491584
Ophthalmological examination abnormal 30.69 12.85 10 112880 68 50492166
Toxic epidermal necrolysis 30.65 12.85 5 112885 20987 50471247
Hypoglycaemia 30.59 12.85 45 112845 53536 50438698
Drug dependence 30.49 12.85 4 112886 19755 50472479
Cutis laxa 30.47 12.85 12 112878 149 50492085
Burning sensation 30.26 12.85 34 112856 45412 50446822
Nasal congestion 30.11 12.85 42 112848 51078 50441156
Joint stiffness 30.04 12.85 15 112875 30293 50461941
Medication error 30.01 12.85 22 112868 36082 50456152
Colorectal cancer metastatic 29.96 12.85 17 112873 498 50491736
Choroidal neovascularisation 29.92 12.85 14 112876 271 50491963
Duodenal ulcer 29.88 12.85 54 112836 6721 50485513
Bronchial fistula 29.82 12.85 8 112882 24 50492210
Extravasation 29.72 12.85 29 112861 1973 50490261
Eye irritation 29.71 12.85 95 112795 17045 50475189
Metastases to spine 29.55 12.85 34 112856 2797 50489437
Loss of consciousness 29.50 12.85 126 112764 104227 50388007
Pelvic infection 29.46 12.85 14 112876 281 50491953
Pulpitis dental 29.38 12.85 20 112870 813 50491421
Swelling face 29.23 12.85 45 112845 52550 50439684
Embolism venous 29.22 12.85 32 112858 2493 50489741
Iridocyclitis 29.15 12.85 29 112861 2020 50490214
Periodontitis 28.96 12.85 35 112855 3034 50489200
Enterocolitis infectious 28.95 12.85 25 112865 1453 50490781
Ureteric fistula 28.79 12.85 7 112883 12 50492222
Biliary fistula 28.79 12.85 7 112883 12 50492222
Magnetic resonance imaging head abnormal 28.77 12.85 27 112863 1750 50490484
Gastrointestinal necrosis 28.48 12.85 32 112858 2566 50489668
Metastases to skin 28.32 12.85 24 112866 1359 50490875
Varices oesophageal 28.28 12.85 33 112857 2756 50489478
Polychromasia 28.25 12.85 10 112880 90 50492144
Angiogram retina abnormal 28.22 12.85 6 112884 3 50492231
Vaginal perforation 28.10 12.85 7 112883 14 50492220
Gastrooesophageal reflux disease 27.78 12.85 83 112807 76345 50415889
BRCA2 gene mutation 27.77 12.85 9 112881 60 50492174
Haemolytic anaemia 27.77 12.85 63 112827 9229 50483005
Accidental overdose 27.76 12.85 5 112885 19528 50472706
Nephrolithiasis 27.73 12.85 22 112868 34671 50457563
Device dislocation 27.59 12.85 7 112883 21539 50470695
Product contamination microbial 27.39 12.85 12 112878 198 50492036
Thrombophlebitis migrans 27.32 12.85 10 112880 100 50492134
Aphasia 27.32 12.85 131 112759 28363 50463871
C-reactive protein increased 27.30 12.85 68 112822 66406 50425828
Anastomotic fistula 27.17 12.85 7 112883 17 50492217
Unevaluable event 26.98 12.85 38 112852 46028 50446206
Immune thrombocytopenia 26.80 12.85 61 112829 8956 50483278
Mycotic endophthalmitis 26.78 12.85 8 112882 39 50492195
Aggression 26.77 12.85 7 112883 21109 50471125
Lacrimation increased 26.61 12.85 91 112799 16901 50475333
Melanoderma 26.61 12.85 11 112879 156 50492078
Macular hole 26.59 12.85 18 112872 725 50491509
Necrosis 26.53 12.85 42 112848 4694 50487540
Rash pruritic 26.53 12.85 41 112849 47805 50444429
Product use in unapproved indication 26.32 12.85 151 112739 115668 50376566
Glioblastoma 26.22 12.85 18 112872 742 50491492
Incisional hernia 26.21 12.85 23 112867 1366 50490868
Neutropenic sepsis 25.98 12.85 80 112810 14067 50478167
Iritis 25.78 12.85 30 112860 2498 50489736
Gastropleural fistula 25.69 12.85 8 112882 46 50492188
Immune-mediated hepatitis 25.64 12.85 19 112871 885 50491349
Basal cell carcinoma 25.60 12.85 10 112880 23346 50468888
Intracranial tumour haemorrhage 25.19 12.85 10 112880 127 50492107
Central nervous system haemorrhage 25.19 12.85 10 112880 127 50492107
Delirium 24.96 12.85 29 112861 38163 50454071
Febrile bone marrow aplasia 24.96 12.85 48 112842 6263 50485971
Pneumatosis intestinalis 24.95 12.85 27 112863 2076 50490158
Hepatic cirrhosis 24.84 12.85 91 112799 17486 50474748
Blood pressure fluctuation 24.73 12.85 26 112864 35797 50456437
Rectal haemorrhage 24.73 12.85 159 112731 38399 50453835
Carpal tunnel syndrome 24.72 12.85 4 112886 16889 50475345
Hypervolaemia 24.70 12.85 13 112877 25486 50466748
Vitreous disorder 24.68 12.85 9 112881 89 50492145
Malaise 24.47 12.85 566 112324 334966 50157268
Cerebral haemorrhage 24.24 12.85 122 112768 26930 50465304
Retinal aneurysm 24.14 12.85 11 112879 200 50492034
Anaemia of malignant disease 24.13 12.85 14 112876 428 50491806
Fungal infection 23.96 12.85 19 112871 29946 50462288
Hyperammonaemia 23.90 12.85 40 112850 4684 50487550
Tooth erosion 23.87 12.85 14 112876 437 50491797
Tumour invasion 23.75 12.85 9 112881 100 50492134
Crying 23.64 12.85 8 112882 20408 50471826
Anterior chamber inflammation 23.58 12.85 12 112878 281 50491953
Dysaesthesia 23.57 12.85 35 112855 3700 50488534
Neoplasm malignant 23.44 12.85 110 112780 23605 50468629
Cerebral infarction 23.44 12.85 103 112787 21501 50470733
Lip swelling 23.40 12.85 13 112877 24723 50467511
Heart rate increased 23.25 12.85 91 112799 77159 50415075
Performance status decreased 23.19 12.85 32 112858 3163 50489071
Post procedural fistula 23.14 12.85 11 112879 221 50492013
Swollen tongue 23.08 12.85 18 112872 28612 50463622
Foot fracture 23.04 12.85 8 112882 20083 50472151
Hypertransaminasaemia 23.02 12.85 34 112856 3577 50488657
Intestinal metastasis 22.98 12.85 9 112881 110 50492124
Tumour fistulisation 22.89 12.85 6 112884 16 50492218
Eczema 22.86 12.85 11 112879 22691 50469543
Mood swings 22.85 12.85 4 112886 15950 50476284
Psychotic disorder 22.84 12.85 10 112880 21802 50470432
Prescribed underdose 22.84 12.85 4 112886 15945 50476289
Colitis ischaemic 22.68 12.85 59 112831 9424 50482810
Lymphadenopathy mediastinal 22.66 12.85 28 112862 2483 50489751
Ovarian cancer 22.66 12.85 41 112849 5108 50487126
Influenza like illness 22.66 12.85 60 112830 57399 50434835
Inferior vena cava stenosis 22.62 12.85 6 112884 17 50492217
Colonic fistula 22.57 12.85 11 112879 234 50492000
Cardiac failure congestive 22.57 12.85 104 112786 84278 50407956
Ankle fracture 22.39 12.85 4 112886 15718 50476516
Blood pressure decreased 22.33 12.85 58 112832 55851 50436383
Optic neuropathy 22.32 12.85 23 112867 1671 50490563
Anastomotic complication 22.27 12.85 9 112881 120 50492114
Oesophageal fistula 22.21 12.85 9 112881 121 50492113
Hydrocephalus 22.19 12.85 39 112851 4749 50487485
Blindness unilateral 22.17 12.85 41 112849 5194 50487040
Myoclonus 22.16 12.85 3 112887 14467 50477767
Cholecystitis acute 22.15 12.85 49 112841 7057 50485177
Eosinophilia 22.14 12.85 7 112883 18645 50473589
Catheter site injury 22.01 12.85 9 112881 124 50492110
Coma 21.97 12.85 60 112830 56819 50435415
Drug ineffective for unapproved indication 21.90 12.85 10 112880 21271 50470963
Joint range of motion decreased 21.88 12.85 7 112883 18505 50473729
Lower limb fracture 21.70 12.85 3 112887 14243 50477991
Perirectal abscess 21.68 12.85 17 112873 862 50491372
Optic ischaemic neuropathy 21.55 12.85 18 112872 999 50491235
Nervousness 21.52 12.85 18 112872 27633 50464601
Oesophageal varices haemorrhage 21.35 12.85 18 112872 1012 50491222
Adenocarcinoma 21.33 12.85 27 112863 2454 50489780
Hypocalcaemia 21.32 12.85 117 112773 26699 50465535
Inflammation 21.27 12.85 61 112829 56851 50435383
Thrombosis 21.23 12.85 204 112686 55629 50436605
Colon cancer metastatic 21.20 12.85 18 112872 1022 50491212
Splenic artery thrombosis 21.19 12.85 7 112883 50 50492184
Biliary dilatation 21.15 12.85 24 112866 1945 50490289
Intestinal fistula 21.11 12.85 16 112874 771 50491463
Myelodysplastic syndrome 21.09 12.85 78 112812 15054 50477180
Dysaesthesia pharynx 21.08 12.85 9 112881 139 50492095
Thyroiditis 20.93 12.85 23 112867 1799 50490435
Amnesia 20.86 12.85 39 112851 42221 50450013
Cytomegalovirus infection 20.86 12.85 7 112883 17955 50474279
Surgery 20.77 12.85 22 112868 30183 50462051
Right ventricular failure 20.66 12.85 5 112885 15888 50476346
Iron deficiency anaemia 20.55 12.85 6 112884 16828 50475406
Incorrect route of product administration 20.45 12.85 8 112882 18658 50473576
Obesity 20.44 12.85 6 112884 16769 50475465
Gallbladder disorder 20.38 12.85 6 112884 16736 50475498
Cardiac ventricular thrombosis 20.38 12.85 13 112877 473 50491761
Thrombotic thrombocytopenic purpura 20.37 12.85 32 112858 3553 50488681
Gallbladder rupture 20.36 12.85 12 112878 378 50491856
Hepatic lesion 20.36 12.85 34 112856 3974 50488260
Seasonal allergy 20.33 12.85 4 112886 14672 50477562
Necrotising fasciitis 20.30 12.85 27 112863 2577 50489657
Herpes zoster 20.29 12.85 85 112805 70701 50421533
Mental disorder 20.17 12.85 12 112878 21979 50470255
Charles Bonnet syndrome 20.07 12.85 5 112885 10 50492224
Soft tissue necrosis 20.00 12.85 12 112878 391 50491843
Eye pain 19.92 12.85 120 112770 28329 50463905
Short-bowel syndrome 19.91 12.85 12 112878 394 50491840
Urine protein/creatinine ratio increased 19.91 12.85 12 112878 394 50491840
Throat irritation 19.72 12.85 23 112867 30216 50462018
Metastases to abdominal cavity 19.62 12.85 12 112878 405 50491829
Diabetic retinal oedema 19.61 12.85 11 112879 315 50491919
Hyperhidrosis 19.56 12.85 118 112772 89308 50402926
Head injury 19.49 12.85 15 112875 24005 50468229
Retinal cyst 19.40 12.85 7 112883 67 50492167
Pharyngeal oedema 19.31 12.85 69 112821 13096 50479138
Intestinal ischaemia 19.30 12.85 45 112845 6712 50485522
Joint effusion 19.24 12.85 3 112887 13018 50479216
Hypermutation 19.19 12.85 6 112884 35 50492199
Respiratory tract infection 19.16 12.85 26 112864 31991 50460243
Injection site haemorrhage 19.08 12.85 12 112878 21334 50470900
Abnormal behaviour 19.08 12.85 10 112880 19648 50472586
Lymphoedema 19.06 12.85 54 112836 9068 50483166
Pelvic fluid collection 19.00 12.85 15 112875 768 50491466
Tachyphylaxis 18.91 12.85 10 112880 254 50491980
Perforation bile duct 18.89 12.85 5 112885 14 50492220
Intestinal prolapse 18.89 12.85 8 112882 121 50492113
Therapeutic response unexpected 18.84 12.85 6 112884 15909 50476325
Metastases to kidney 18.75 12.85 9 112881 185 50492049
Brachiocephalic vein thrombosis 18.70 12.85 7 112883 75 50492159
Procedural pain 18.69 12.85 4 112886 13828 50478406
Failure to anastomose 18.64 12.85 5 112885 15 50492219
Panic attack 18.53 12.85 10 112880 19332 50472902
Mediastinal disorder 18.51 12.85 11 112879 352 50491882
Toxic cardiomyopathy 18.48 12.85 8 112882 128 50492106
Metastases to pelvis 18.45 12.85 11 112879 354 50491880
Metastases to vagina 18.40 12.85 5 112885 16 50492218
Impaired work ability 18.32 12.85 4 112886 13636 50478598
Retinal depigmentation 18.29 12.85 10 112880 272 50491962
Congestive cardiomyopathy 18.29 12.85 39 112851 5479 50486755
Aneurysm 18.20 12.85 25 112865 2460 50489774
Rectal cancer recurrent 18.17 12.85 5 112885 17 50492217
Bladder perforation 18.15 12.85 8 112882 134 50492100
Retinal vascular occlusion 18.10 12.85 11 112879 367 50491867
Splenomegaly 18.09 12.85 55 112835 9605 50482629
Hepatic pain 17.94 12.85 26 112864 2689 50489545
Transaminases 17.91 12.85 7 112883 85 50492149
Peritoneal neoplasm 17.79 12.85 6 112884 46 50492188
Bacterial diarrhoea 17.79 12.85 6 112884 46 50492188
Breast necrosis 17.73 12.85 8 112882 142 50492092
Intestinal strangulation 17.69 12.85 7 112883 88 50492146
Neoplasm recurrence 17.60 12.85 24 112866 2345 50489889
Disease recurrence 17.60 12.85 90 112800 19991 50472243
Gastroenteritis viral 17.58 12.85 10 112880 18776 50473458
Angioedema 17.54 12.85 36 112854 37640 50454594
Dry age-related macular degeneration 17.53 12.85 8 112882 146 50492088
Kidney infection 17.52 12.85 10 112880 18736 50473498
Vena cava thrombosis 17.38 12.85 22 112868 1999 50490235
Wound decomposition 17.34 12.85 5 112885 21 50492213
Blood glucose increased 17.29 12.85 91 112799 71233 50421001
Depressed mood 17.15 12.85 31 112859 33992 50458242
Localised infection 17.03 12.85 19 112871 25466 50466768
Pulmonary artery thrombosis 17.02 12.85 13 112877 634 50491600
Retinal vein occlusion 17.02 12.85 21 112869 1860 50490374
Nail disorder 17 12.85 54 112836 9654 50482580
Creatinine renal clearance decreased 16.97 12.85 3 112887 11878 50480356
Retinal ischaemia 16.97 12.85 10 112880 315 50491919
Tendonitis 16.96 12.85 8 112882 16697 50475537
Transfusion 16.90 12.85 4 112886 12901 50479333
Enterocolitis 16.89 12.85 42 112848 6525 50485709
Haemorrhage 16.87 12.85 188 112702 53253 50438981
Immunodeficiency 16.84 12.85 6 112884 14822 50477412
Malignant hypertension 16.78 12.85 16 112874 1058 50491176
Secondary cerebellar degeneration 16.76 12.85 6 112884 56 50492178
Tumour pain 16.75 12.85 17 112873 1213 50491021
White blood cell count increased 16.73 12.85 44 112846 42196 50450038
Toxic anterior segment syndrome 16.68 12.85 19 112871 1546 50490688
Abdominal hernia 16.68 12.85 33 112857 4396 50487838
Thrombocytopenic purpura 16.57 12.85 17 112873 1229 50491005
Psoas abscess 16.56 12.85 11 112879 429 50491805
Sciatica 16.54 12.85 14 112876 21368 50470866
Product counterfeit 16.52 12.85 7 112883 106 50492128
Recurrent cancer 16.52 12.85 20 112870 1737 50490497
Emotional distress 16.43 12.85 24 112866 28639 50463595
Trichiasis 16.39 12.85 6 112884 60 50492174
Respiratory arrest 16.36 12.85 26 112864 29983 50462251
Tooth disorder 16.26 12.85 18 112872 24210 50468024
Intracranial hypotension 16.13 12.85 9 112881 255 50491979
Respiratory disorder 16.10 12.85 28 112862 31159 50461075
Arterioenteric fistula 16.05 12.85 4 112886 8 50492226
Application site recall reaction 16.05 12.85 4 112886 8 50492226
Birdshot chorioretinopathy 16.05 12.85 6 112884 64 50492170
Heart rate decreased 16.05 12.85 36 112854 36461 50455773
Ureteric stenosis 16.04 12.85 12 112878 567 50491667
Skin hyperpigmentation 16.02 12.85 36 112854 5240 50486994
Coronary artery disease 15.98 12.85 26 112864 29700 50462534
Sputum discoloured 15.95 12.85 5 112885 13390 50478844
Exposed bone in jaw 15.92 12.85 25 112865 2775 50489459
Wound necrosis 15.87 12.85 10 112880 356 50491878
Blood triglycerides increased 15.85 12.85 3 112887 11309 50480925
Infusion site pain 15.83 12.85 4 112886 12342 50479892
Heart rate irregular 15.83 12.85 12 112878 19348 50472886
Seizure 15.77 12.85 359 112531 117515 50374719
Retroperitoneal lymphadenopathy 15.74 12.85 11 112879 467 50491767
White blood cell count 15.72 12.85 6 112884 68 50492166
Cystitis haemorrhagic 15.69 12.85 29 112861 3673 50488561
Product storage error 15.59 12.85 4 112886 12220 50480014
Metastases to gastrointestinal tract 15.57 12.85 6 112884 70 50492164
Focal segmental glomerulosclerosis 15.53 12.85 17 112873 1324 50490910
Balance disorder 15.51 12.85 93 112797 70497 50421737
Hiatus hernia 15.47 12.85 11 112879 18333 50473901
Hepatic vein stenosis 15.47 12.85 5 112885 33 50492201
Road traffic accident 15.37 12.85 19 112871 24333 50467901
Bursitis 15.35 12.85 16 112874 22119 50470115
Unresponsive to stimuli 15.33 12.85 28 112862 30581 50461653
Serous cystadenocarcinoma ovary 15.32 12.85 3 112887 0 50492234
Eastern Cooperative Oncology Group performance status improved 15.32 12.85 3 112887 0 50492234
Instillation site complication 15.32 12.85 3 112887 0 50492234
Retinal telangiectasia 15.32 12.85 3 112887 0 50492234
Cyclitis 15.32 12.85 3 112887 0 50492234
Infected lymphocele 15.21 12.85 8 112882 201 50492033
Gait inability 15.11 12.85 38 112852 36989 50455245
Peripheral paralysis 15.06 12.85 6 112884 77 50492157
Gastrointestinal obstruction 14.95 12.85 14 112876 905 50491329
Pulmonary arterial hypertension 14.88 12.85 14 112876 20305 50471929
Mean cell volume increased 14.81 12.85 25 112865 2947 50489287
Disability 14.80 12.85 5 112885 12770 50479464
Fear 14.72 12.85 7 112883 14542 50477692
Glomerulonephropathy 14.72 12.85 6 112884 82 50492152
Paraneoplastic syndrome 14.66 12.85 11 112879 522 50491712
Skin discolouration 14.66 12.85 32 112858 32725 50459509
Pneumonia chlamydial 14.59 12.85 6 112884 84 50492150
Jaundice 14.57 12.85 105 112785 26324 50465910
Acute coronary syndrome 14.50 12.85 50 112840 9324 50482910
Rash papular 14.49 12.85 5 112885 12599 50479635
Epilepsy 14.49 12.85 90 112800 21477 50470757
Arterial thrombosis 14.46 12.85 16 112874 1261 50490973
Hypersplenism 14.39 12.85 8 112882 225 50492009
Catheter site bruise 14.37 12.85 9 112881 317 50491917
Colitis ulcerative 14.36 12.85 10 112880 16844 50475390
Limb discomfort 14.35 12.85 20 112870 24337 50467897
Cutaneous tuberculosis 14.32 12.85 7 112883 150 50492084
Intercepted medication error 14.21 12.85 10 112880 429 50491805
Vascular access complication 14.21 12.85 15 112875 1121 50491113
Renal tubular disorder 14.19 12.85 22 112868 2415 50489819
Metastases to soft tissue 14.19 12.85 7 112883 153 50492081
Pulmonary cavitation 14.18 12.85 12 112878 678 50491556
Tongue ulceration 14.16 12.85 25 112865 3055 50489179
Uterine adhesions 14.13 12.85 5 112885 45 50492189
Restless legs syndrome 14.13 12.85 9 112881 15888 50476346
Hyperlipidaemia 14.09 12.85 11 112879 17479 50474755
Blood glucose decreased 14.00 12.85 12 112878 18199 50474035
Retinopathy proliferative 13.93 12.85 5 112885 47 50492187
Carbohydrate antigen 19-9 increased 13.91 12.85 7 112883 160 50492074
Cognitive disorder 13.91 12.85 51 112839 44072 50448162
Paraesthesia 13.90 12.85 359 112531 119884 50372350
Chest discomfort 13.84 12.85 136 112754 92586 50399648
Posterior capsule opacification 13.75 12.85 6 112884 98 50492136
Obstructive airways disorder 13.72 12.85 9 112881 15643 50476591
Budd-Chiari syndrome 13.66 12.85 5 112885 50 50492184
Bone marrow infiltration 13.64 12.85 10 112880 458 50491776
Grip strength decreased 13.60 12.85 5 112885 12116 50480118
Lymphorrhoea 13.57 12.85 5 112885 51 50492183
Proctitis 13.53 12.85 19 112871 1909 50490325
Full blood count decreased 13.52 12.85 18 112872 22328 50469906
Alopecia 13.50 12.85 430 112460 244617 50247617
Ulcerative keratitis 13.50 12.85 21 112869 2312 50489922
Glioblastoma multiforme 13.48 12.85 12 112878 726 50491508
Macular pigmentation 13.48 12.85 4 112886 19 50492215
Injection related reaction 13.46 12.85 11 112879 592 50491642
Metastases to chest wall 13.45 12.85 10 112880 468 50491766
Gastric varices haemorrhage 13.43 12.85 6 112884 104 50492130
Bone density decreased 13.43 12.85 4 112886 11071 50481163
Pseudocyst 13.41 12.85 7 112883 173 50492061
Head discomfort 13.32 12.85 4 112886 11015 50481219
Tumour cavitation 13.25 12.85 3 112887 3 50492231
Tumour obstruction 13.25 12.85 3 112887 3 50492231
Dystonia 13.25 12.85 5 112885 11921 50480313
Wound infection 13.24 12.85 58 112832 12090 50480144
Cholangitis sclerosing 13.24 12.85 15 112875 1214 50491020
Postoperative adhesion 13.21 12.85 8 112882 265 50491969
Anterior chamber cell 13.16 12.85 10 112880 484 50491750
Incarcerated incisional hernia 13.15 12.85 4 112886 21 50492213
Vitreous degeneration 13.15 12.85 4 112886 21 50492213
Nail pigmentation 13.12 12.85 7 112883 181 50492053
Torsade de pointes 13.08 12.85 5 112885 11830 50480404
Bone pain 13.07 12.85 162 112728 47067 50445167
Hyperpyrexia 13.06 12.85 24 112866 3025 50489209
Dermatitis allergic 13.06 12.85 6 112884 12714 50479520
Urinary fistula 12.99 12.85 4 112886 22 50492212
Acute respiratory failure 12.98 12.85 28 112862 28754 50463480
Subarachnoid haemorrhage 12.95 12.85 53 112837 10723 50481511
Microangiopathic haemolytic anaemia 12.94 12.85 10 112880 496 50491738

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 1802.32 13.39 1646 83345 80270 29409266
Death 1405.02 13.39 3044 81947 339040 29150496
Proteinuria 811.62 13.39 527 84464 15277 29474259
Gastrointestinal perforation 740.81 13.39 303 84688 3180 29486356
Off label use 539.59 13.39 1988 83003 298812 29190724
Endophthalmitis 479.85 13.39 210 84781 2638 29486898
Palmar-plantar erythrodysaesthesia syndrome 433.74 13.39 351 84640 14408 29475128
Drug interaction 316.62 13.39 88 84903 197297 29292239
Diarrhoea 288.96 13.39 1784 83207 330914 29158622
Intestinal perforation 251.78 13.39 199 84792 7887 29481649
Peritonitis 251.36 13.39 259 84732 14565 29474971
Hypertension 244.87 13.39 814 84177 115800 29373736
Large intestine perforation 239.78 13.39 186 84805 7170 29482366
Completed suicide 234.99 13.39 5 84986 90241 29399295
Neuropathy peripheral 229.62 13.39 579 84412 70448 29419088
Macular oedema 215.77 13.39 116 84875 2342 29487194
Drug ineffective 214.67 13.39 453 84538 362717 29126819
Toxicity to various agents 197.71 13.39 128 84863 173533 29316003
Epistaxis 196.65 13.39 449 84542 51255 29438281
Bone marrow failure 194.84 13.39 311 84680 27138 29462398
Suspected transmission of an infectious agent via product 192.12 13.39 71 84920 552 29488984
Myelosuppression 176.18 13.39 196 84795 12031 29477505
Interstitial lung disease 172.53 13.39 457 84534 57261 29432275
Stomatitis 164.65 13.39 343 84648 36770 29452766
Small intestinal perforation 163.10 13.39 84 84907 1548 29487988
Product dose omission issue 161.86 13.39 39 84952 96344 29393192
Mucosal inflammation 158.07 13.39 307 84684 31288 29458248
Vitreous floaters 152.57 13.39 101 84890 3020 29486516
Pulmonary embolism 151.39 13.39 524 84467 76010 29413526
Nephrotic syndrome 147.91 13.39 132 84859 6196 29483340
Metastases to liver 147.19 13.39 176 84815 11680 29477856
Overdose 144.86 13.39 27 84964 79792 29409744
Intestinal obstruction 144.52 13.39 224 84767 19053 29470483
Metastases to lung 143.65 13.39 143 84848 7712 29481824
Dehydration 141.89 13.39 679 84312 114069 29375467
Neoplasm progression 139.14 13.39 216 84775 18396 29471140
Decreased appetite 138.46 13.39 800 84191 144542 29344994
Anastomotic leak 134.08 13.39 54 84937 542 29488994
Tumour haemorrhage 132.70 13.39 85 84906 2400 29487136
Neutropenia 127.39 13.39 728 84263 130983 29358553
Intentional product use issue 124.42 13.39 334 84657 42164 29447372
Necrotising fasciitis 122.71 13.39 91 84900 3274 29486262
Condition aggravated 117.30 13.39 149 84842 146146 29343390
Rectal perforation 117.21 13.39 44 84947 359 29489177
Neutrophil count decreased 116.25 13.39 331 84660 43236 29446300
Protein urine 115.49 13.39 53 84938 749 29488787
Vomiting 115.39 13.39 1020 83971 211240 29278296
Varices oesophageal 114.55 13.39 85 84906 3061 29486475
Wound dehiscence 110.94 13.39 82 84909 2935 29486601
Tumour perforation 108.00 13.39 37 84954 224 29489312
Portal hypertension 106.80 13.39 85 84906 3401 29486135
Visual acuity reduced 104.77 13.39 168 84823 14708 29474828
Gastrointestinal toxicity 97.06 13.39 66 84925 2065 29487471
Rhabdomyolysis 95.60 13.39 28 84963 60780 29428756
Malignant neoplasm progression 94.78 13.39 442 84549 73417 29416119
Neurotoxicity 94.76 13.39 159 84832 14454 29475082
Pneumothorax 94.37 13.39 166 84825 15676 29473860
Hospitalisation 91.46 13.39 12 84979 45976 29443560
Alopecia 91.25 13.39 182 84809 18902 29470634
Detachment of retinal pigment epithelium 90.77 13.39 37 84954 384 29489152
Oesophageal varices haemorrhage 89.52 13.39 69 84922 2633 29486903
Tumour necrosis 86.96 13.39 49 84942 1088 29488448
Anastomotic complication 86.81 13.39 34 84957 315 29489221
Vitreous haemorrhage 86.15 13.39 60 84931 1953 29487583
Retinal haemorrhage 86.07 13.39 84 84907 4420 29485116
Nausea 84.95 13.39 1232 83759 288023 29201513
Ileal perforation 83.96 13.39 41 84950 671 29488865
Plasma cell myeloma 83.45 13.39 6 84985 37109 29452427
Suture rupture 83.11 13.39 33 84958 318 29489218
Ascites 82.36 13.39 262 84729 36357 29453179
Abdominal pain 80.50 13.39 664 84327 134693 29354843
Suicidal ideation 79.85 13.39 5 84986 34711 29454825
Electrocardiogram QT prolonged 78.03 13.39 7 84984 36130 29453406
Dizziness 76.34 13.39 284 84707 189400 29300136
Protein urine present 75.92 13.39 80 84911 4614 29484922
Rheumatoid arthritis 72.86 13.39 5 84986 32147 29457389
Increased insulin requirement 72.78 13.39 21 84970 64 29489472
Bradycardia 72.34 13.39 50 84941 65579 29423957
Ileus 72.06 13.39 140 84851 14262 29475274
Carcinoembryonic antigen increased 70.80 13.39 35 84956 589 29488947
Impaired healing 70.54 13.39 134 84857 13424 29476112
Cardiac failure congestive 70.03 13.39 70 84921 76511 29413025
Disseminated intravascular coagulation 69.86 13.39 168 84823 19812 29469724
Feeling abnormal 69.14 13.39 35 84956 54410 29435126
Embolism 69.09 13.39 92 84899 6804 29482732
Metastases to peritoneum 69.04 13.39 47 84944 1473 29488063
Intentional product misuse 69.02 13.39 9 84982 34652 29454884
Aggression 68.95 13.39 10 84981 35531 29454005
Fall 68.87 13.39 269 84722 176909 29312627
Skin toxicity 67.74 13.39 68 84923 3703 29485833
Perforation 66.74 13.39 24 84967 171 29489365
Metastases to central nervous system 66.68 13.39 92 84899 7039 29482497
Large intestinal obstruction 66.62 13.39 44 84947 1310 29488226
Injection site pain 65.64 13.39 8 84983 32438 29457098
Fatigue 65.26 13.39 1274 83717 315547 29173989
Pruritus 64.32 13.39 151 84840 116698 29372838
Anxiety 64.22 13.39 91 84900 85274 29404262
Deep vein thrombosis 63.95 13.39 330 84661 57069 29432467
Oesophagobronchial fistula 63.83 13.39 22 84969 136 29489400
Eye inflammation 62.14 13.39 46 84945 1650 29487886
Asthma 60.21 13.39 12 84979 33837 29455699
Incorrect dose administered 60.14 13.39 11 84980 32973 29456563
Joint swelling 59.94 13.39 34 84957 49596 29439940
Tremor 59.79 13.39 74 84917 73464 29416072
Stoma site haemorrhage 57.84 13.39 32 84959 685 29488851
Arthralgia 57.46 13.39 207 84784 139410 29350126
Metastases to meninges 56.50 13.39 38 84953 1167 29488369
Cystoid macular oedema 55.78 13.39 30 84961 606 29488930
Duodenal perforation 54.76 13.39 37 84954 1145 29488391
Wrong technique in product usage process 54.13 13.39 12 84979 31416 29458120
Retinal pigment epithelial tear 53.66 13.39 22 84969 232 29489304
Colon cancer metastatic 53.64 13.39 40 84951 1451 29488085
Vitritis 53.37 13.39 30 84961 663 29488873
Thrombocytopenia 53.24 13.39 607 84384 134216 29355320
Small intestinal obstruction 52.46 13.39 116 84875 12945 29476591
Blindness 51.97 13.39 110 84881 11913 29477623
Macular fibrosis 51.68 13.39 24 84967 349 29489187
Dermatitis acneiform 51.58 13.39 71 84920 5420 29484116
Arteriospasm coronary 51.20 13.39 49 84942 2516 29487020
Portal vein thrombosis 51.05 13.39 55 84936 3254 29486282
Haemoptysis 50.89 13.39 198 84793 30352 29459184
Fistula 50.62 13.39 68 84923 5071 29484465
Hypopyon 50.50 13.39 23 84968 319 29489217
Haematotoxicity 50.40 13.39 78 84913 6621 29482915
Haemorrhage 50.10 13.39 259 84732 44813 29444723
Hallucination 49.34 13.39 34 84957 44678 29444858
COVID-19 49.04 13.39 21 84970 35993 29453543
Neoplasm 48.75 13.39 60 84931 4101 29485435
Cataract nuclear 48.62 13.39 25 84966 459 29489077
Acute kidney injury 48.11 13.39 509 84482 264758 29224778
Peripheral swelling 47.87 13.39 68 84923 63671 29425865
Angioedema 47.81 13.39 16 84975 31899 29457637
Hyperammonaemia 46.96 13.39 69 84922 5594 29483942
Hypoglycaemia 46.75 13.39 42 84949 48304 29441232
Failure to anastomose 46.71 13.39 19 84972 196 29489340
Glomerular vascular disorder 46.67 13.39 15 84976 72 29489464
Musculoskeletal stiffness 46.19 13.39 25 84966 37433 29452103
Drug dependence 45.46 13.39 4 84987 20977 29468559
Myalgia 45.39 13.39 90 84901 73929 29415607
Subileus 45.08 13.39 48 84943 2802 29486734
Retinal oedema 45.06 13.39 25 84966 538 29488998
Performance status decreased 44.08 13.39 54 84937 3673 29485863
Adverse drug reaction 43.81 13.39 8 84983 24012 29465524
Agitation 43.42 13.39 50 84941 51254 29438282
Suspected counterfeit product 42.82 13.39 19 84972 247 29489289
Blood glucose increased 42.27 13.39 65 84926 58919 29430617
Lactic acidosis 42.21 13.39 17 84974 30230 29459306
Anastomotic fistula 41.95 13.39 13 84978 54 29489482
General physical health deterioration 41.89 13.39 466 84525 102391 29387145
Enteritis 41.52 13.39 72 84919 6719 29482817
Prostate cancer 41.51 13.39 11 84980 25516 29464020
Fistula of small intestine 41.41 13.39 21 84970 374 29489162
Drug hypersensitivity 41.24 13.39 84 84907 68322 29421214
Polyneuropathy 41.21 13.39 101 84890 12051 29477485
Contraindicated product administered 40.92 13.39 3 84988 18263 29471273
Pneumatosis intestinalis 40.90 13.39 48 84943 3121 29486415
Peripheral sensory neuropathy 40.35 13.39 66 84925 5873 29483663
Stomal varices 40.33 13.39 12 84979 42 29489494
Venous thrombosis 40.31 13.39 47 84944 3035 29486501
Drug withdrawal syndrome 40.16 13.39 3 84988 17981 29471555
Tumour rupture 40.05 13.39 17 84974 197 29489339
Muscle spasms 40.02 13.39 79 84912 65003 29424533
Subretinal fluid 39.97 13.39 19 84972 292 29489244
Acral peeling skin syndrome 39.90 13.39 12 84979 44 29489492
Drug level increased 39.60 13.39 4 84987 18783 29470753
Abnormal behaviour 39.49 13.39 9 84982 23118 29466418
Malignant ascites 39.40 13.39 20 84971 357 29489179
Metamorphopsia 39.39 13.39 22 84969 480 29489056
Myocardial infarction 39.34 13.39 173 84818 110123 29379413
Depression 39.28 13.39 120 84871 85027 29404509
Mean cell haemoglobin increased 39.14 13.39 30 84961 1135 29488401
Accidental overdose 39.10 13.39 3 84988 17590 29471946
Eastern Cooperative Oncology Group performance status worsened 39.05 13.39 25 84966 705 29488831
Venous thrombosis limb 38.88 13.39 35 84956 1661 29487875
Constipation 38.51 13.39 499 84492 113661 29375875
Chronic kidney disease 38.47 13.39 29 84962 36387 29453149
Influenza 37.45 13.39 39 84952 41842 29447694
Gastrointestinal anastomotic leak 37.29 13.39 19 84972 342 29489194
Hiccups 37.11 13.39 80 84911 8773 29480763
Eosinophilia 37.09 13.39 9 84982 22152 29467384
Psychotic disorder 36.65 13.39 7 84984 20347 29469189
Sleep apnoea syndrome 36.44 13.39 4 84987 17595 29471941
Posterior reversible encephalopathy syndrome 36.36 13.39 80 84911 8896 29480640
Metastasis 36.29 13.39 47 84944 3382 29486154
Osteonecrosis of jaw 36.08 13.39 117 84874 16393 29473143
Cytomegalovirus infection 35.91 13.39 11 84980 23204 29466332
Retinal detachment 35.87 13.39 55 84936 4631 29484905
Ciliary hyperaemia 35.82 13.39 10 84981 26 29489510
Urticaria 35.67 13.39 64 84927 54596 29434940
Asthenia 35.58 13.39 839 84152 214411 29275125
Toxic epidermal necrolysis 35.46 13.39 5 84986 18148 29471388
Weight increased 35.40 13.39 108 84883 76559 29412977
Coronary artery disease 35.35 13.39 45 84946 44145 29445391
Cellulitis 35.32 13.39 48 84943 45792 29443744
Cardiac disorder 35.27 13.39 33 84958 37230 29452306
Irritability 35.17 13.39 10 84981 22142 29467394
Coma 34.98 13.39 37 84954 39413 29450123
Cholangitis 34.97 13.39 71 84920 7466 29482070
Fluid retention 34.96 13.39 12 84979 23548 29465988
Proteus infection 34.94 13.39 25 84966 850 29488686
Product use in unapproved indication 34.91 13.39 130 84861 86745 29402791
Psoriasis 34.90 13.39 25 84966 32202 29457334
Hypotension 34.74 13.39 374 84617 193980 29295556
Diabetes mellitus 34.60 13.39 38 84953 39793 29449743
Bronchitis 34.49 13.39 33 84958 36835 29452701
Pelvic abscess 34.45 13.39 25 84966 869 29488667
Nasal septum perforation 34.43 13.39 13 84978 108 29489428
Sedation 33.52 13.39 5 84986 17400 29472136
Treatment noncompliance 33.19 13.39 14 84977 24213 29465323
Hemiparesis 32.87 13.39 104 84887 14382 29475154
Pyrexia 32.86 13.39 1069 83922 286553 29202983
Leukoencephalopathy 32.84 13.39 47 84944 3720 29485816
Anaemia of malignant disease 32.84 13.39 18 84973 378 29489158
Pulmonary artery thrombosis 32.75 13.39 21 84970 594 29488942
Proctalgia 32.74 13.39 50 84941 4195 29485341
Anal haemorrhage 32.73 13.39 34 84957 1928 29487608
Mean cell volume increased 32.62 13.39 38 84953 2451 29487085
Pseudoendophthalmitis 32.57 13.39 10 84981 40 29489496
Tumour marker increased 32.54 13.39 20 84971 524 29489012
Macular ischaemia 32.47 13.39 11 84980 64 29489472
Basal cell carcinoma 32.24 13.39 5 84986 16905 29472631
Metastases to bone 32.23 13.39 81 84910 9817 29479719
Non-infectious endophthalmitis 32.14 13.39 13 84978 132 29489404
Wound infection 32.10 13.39 60 84931 5936 29483600
Pain in extremity 32.08 13.39 186 84805 110247 29379289
Retinal disorder 32.06 13.39 24 84967 876 29488660
Colorectal cancer metastatic 31.98 13.39 20 84971 541 29488995
Macular hole 31.90 13.39 14 84977 177 29489359
Cardiac arrest 31.89 13.39 132 84859 85459 29404077
Pneumonia 31.84 13.39 690 84301 319482 29170054
Disturbance in attention 31.64 13.39 11 84980 21413 29468123
Retinal vascular disorder 31.55 13.39 13 84978 139 29489397
Blindness transient 31.54 13.39 33 84958 1887 29487649
Thrombotic microangiopathy 31.42 13.39 74 84917 8607 29480929
Tracheal fistula 31.38 13.39 11 84980 72 29489464
Loss of personal independence in daily activities 31.33 13.39 17 84974 25423 29464113
Gastrointestinal necrosis 31.32 13.39 41 84950 2981 29486555
Psoriatic arthropathy 31.30 13.39 3 84988 14688 29474848
Insomnia 31.17 13.39 140 84851 88621 29400915
Diabetic retinopathy 30.84 13.39 30 84961 1572 29487964
Dysphonia 30.82 13.39 123 84868 19073 29470463
Vitreous detachment 30.72 13.39 22 84969 749 29488787
Palpitations 30.71 13.39 29 84962 32575 29456961
Aortic dissection 30.58 13.39 36 84955 2348 29487188
Pancytopenia 30.53 13.39 129 84862 83039 29406497
No adverse event 30.51 13.39 115 84876 17363 29472173
Cerebral ischaemia 30.45 13.39 57 84934 5646 29483890
Glioblastoma 30.33 13.39 24 84967 952 29488584
Bronchial fistula 30.15 13.39 13 84978 157 29489379
Restlessness 30.01 13.39 13 84978 22132 29467404
International normalised ratio increased 29.81 13.39 51 84940 44321 29445215
Gastric perforation 29.70 13.39 34 84957 2152 29487384
Full blood count abnormal 29.64 13.39 4 84987 15009 29474527
Bleeding varicose vein 29.54 13.39 15 84976 268 29489268
Transmission of an infectious agent via product 29.50 13.39 13 84978 166 29489370
Ocular discomfort 29.50 13.39 30 84961 1659 29487877
Ureteric compression 29.36 13.39 13 84978 168 29489368
Injection site erythema 29.34 13.39 3 84988 13953 29475583
Perirectal abscess 29.27 13.39 28 84963 1437 29488099
Mycotic endophthalmitis 29.12 13.39 9 84982 37 29489499
Malignant glioma 28.88 13.39 8 84983 20 29489516
Somnolence 28.50 13.39 156 84835 93799 29395737
Hyperhidrosis 28.33 13.39 93 84898 64447 29425089
Respiratory depression 28.19 13.39 3 84988 13520 29476016
Enterovesical fistula 27.89 13.39 19 84972 596 29488940
Bladder perforation 27.88 13.39 14 84977 244 29489292
Uveitis 27.56 13.39 56 84935 5891 29483645
Anal fissure 27.42 13.39 37 84954 2771 29486765
Peritoneal disorder 27.37 13.39 14 84977 254 29489282
Immune thrombocytopenia 27.27 13.39 66 84925 7811 29481725
Macular scar 26.89 13.39 8 84983 28 29489508
Acute abdomen 26.88 13.39 29 84962 1718 29487818
Wound complication 26.88 13.39 31 84960 1978 29487558
Oesophageal haemorrhage 26.84 13.39 24 84967 1129 29488407
Choroidal neovascularisation 26.61 13.39 13 84978 213 29489323
Hyperkalaemia 26.57 13.39 89 84902 61303 29428233
Cutis laxa 26.49 13.39 10 84981 83 29489453
Rectal ulcer 26.47 13.39 21 84970 836 29488700
Type II hypersensitivity 26.46 13.39 8 84983 30 29489506
Sinusitis 26.42 13.39 36 84955 34314 29455222
Induration 26.07 13.39 21 84970 855 29488681
Enterocutaneous fistula 25.88 13.39 20 84971 766 29488770
Magnetic resonance imaging head abnormal 25.69 13.39 24 84967 1195 29488341
Subretinal fibrosis 25.69 13.39 10 84981 91 29489445
Metastatic neoplasm 25.57 13.39 35 84956 2657 29486879
Hyperammonaemic encephalopathy 25.45 13.39 30 84961 1960 29487576
Wheezing 25.41 13.39 35 84956 33205 29456331
Unevaluable event 25.35 13.39 29 84962 29822 29459714
Osteonecrosis 25.32 13.39 91 84900 13428 29476108
Abdominal abscess 25.31 13.39 42 84949 3782 29485754
Dyskinesia 25.30 13.39 13 84978 20048 29469488
Metastases to adrenals 25.26 13.39 21 84970 894 29488642
Abscess 24.88 13.39 73 84918 9689 29479847
Therapeutic product effect decreased 24.59 13.39 29 84962 29422 29460114
Platelet count decreased 24.55 13.39 430 84561 104242 29385294
Clostridium difficile infection 24.33 13.39 8 84983 16133 29473403
Pulmonary haemorrhage 24.28 13.39 70 84921 9200 29480336
Diverticular perforation 24.23 13.39 36 84955 2948 29486588
Loss of consciousness 24.12 13.39 120 84871 73936 29415600
Varicose vein ruptured 23.86 13.39 7 84984 23 29489513
Red cell distribution width increased 23.84 13.39 46 84945 4661 29484875
Oesophagitis 23.83 13.39 82 84909 11841 29477695
Stevens-Johnson syndrome 23.46 13.39 9 84982 16488 29473048
Pelvic venous thrombosis 23.46 13.39 16 84975 503 29489033
Eye haemorrhage 23.35 13.39 40 84951 3696 29485840
Enterocolitis 23.24 13.39 56 84935 6610 29482926
Duodenal ulcer perforation 23.18 13.39 25 84966 1481 29488055
Granulocyte count decreased 23.03 13.39 17 84974 607 29488929
Device related thrombosis 22.97 13.39 20 84971 908 29488628
Ocular hypertension 22.97 13.39 18 84973 704 29488832
Road traffic accident 22.96 13.39 8 84983 15553 29473983
Intracranial tumour haemorrhage 22.94 13.39 13 84978 292 29489244
Visual impairment 22.84 13.39 155 84836 29553 29459983
Prothrombin level decreased 22.63 13.39 21 84970 1037 29488499
Lacrimation increased 22.60 13.39 57 84934 6923 29482613
Anal fistula 22.48 13.39 42 84949 4153 29485383
Abdominal discomfort 22.45 13.39 67 84924 47836 29441700
Hypercreatinaemia 22.26 13.39 10 84981 134 29489402
Anal ulcer 22.23 13.39 17 84974 641 29488895
Retinal exudates 21.95 13.39 17 84974 653 29488883
Rectal cancer metastatic 21.94 13.39 11 84980 191 29489345
Tongue geographic 21.93 13.39 5 84986 3 29489533
Change of bowel habit 21.78 13.39 20 84971 974 29488562
Intravascular haemolysis 21.77 13.39 14 84977 398 29489138
Swelling face 21.75 13.39 16 84975 20334 29469202
Ventricular tachycardia 21.35 13.39 20 84971 22554 29466982
Hypophagia 21.17 13.39 117 84874 20755 29468781
Myoclonus 21.14 13.39 6 84985 13303 29476233
Intracranial hypotension 21.10 13.39 11 84980 208 29489328
Intestinal metastasis 21.08 13.39 10 84981 153 29489383
Leukopenia 21.04 13.39 247 84744 54956 29434580
Drug intolerance 21.03 13.39 70 84921 48309 29441227
Gastrointestinal disorder 21.02 13.39 148 84843 28558 29460978
Infectious pleural effusion 21.00 13.39 27 84964 1929 29487607
Respiratory arrest 20.97 13.39 26 84965 25807 29463729
Cerebral infarction 20.96 13.39 132 84859 24543 29464993
Proctitis 20.81 13.39 28 84963 2091 29487445
Eczema 20.59 13.39 7 84984 13819 29475717
IIIrd nerve paralysis 20.56 13.39 14 84977 439 29489097
Colitis 20.54 13.39 157 84834 31091 29458445
Blood creatine phosphokinase increased 20.40 13.39 55 84936 40589 29448947
Therapy cessation 20.39 13.39 8 84983 14454 29475082
Microangiopathic haemolytic anaemia 20.30 13.39 18 84973 837 29488699
Hypertensive crisis 20.30 13.39 59 84932 7789 29481747
Retinal aneurysm 20.28 13.39 9 84982 117 29489419
Rectourethral fistula 20.17 13.39 6 84985 21 29489515
Memory impairment 20.13 13.39 47 84944 36423 29453113
Medulloblastoma 20.08 13.39 7 84984 45 29489491
Metastases to lymph nodes 20.03 13.39 39 84952 3978 29485558
Hepatic failure 19.97 13.39 157 84834 31355 29458181
Therapeutic product effect incomplete 19.87 13.39 53 84938 39252 29450284
Pulmonary infarction 19.86 13.39 20 84971 1093 29488443
Pulmonary oedema 19.86 13.39 60 84931 42675 29446861
Anterior chamber inflammation 19.82 13.39 11 84980 237 29489299
Hypervolaemia 19.81 13.39 13 84978 17532 29472004
Hot flush 19.72 13.39 9 84982 14861 29474675
Cachexia 19.68 13.39 51 84940 6298 29483238
Mouth ulceration 19.65 13.39 70 84921 10285 29479251
Liver function test abnormal 19.64 13.39 33 84958 28885 29460651
Thrombophlebitis migrans 19.63 13.39 8 84983 83 29489453
Thrombotic thrombocytopenic purpura 19.61 13.39 34 84957 3172 29486364
Blister 19.59 13.39 17 84974 19889 29469647
Vascular pseudoaneurysm 19.52 13.39 26 84965 1923 29487613
Retinal vein occlusion 19.52 13.39 23 84968 1502 29488034
Underdose 19.51 13.39 5 84986 11864 29477672
Carbohydrate antigen 19-9 increased 19.48 13.39 10 84981 183 29489353
Perihepatic abscess 19.38 13.39 8 84983 86 29489450
Arthropathy 19.34 13.39 20 84971 21534 29468002
Hepatic function abnormal 19.34 13.39 185 84806 39074 29450462
Prostatic specific antigen increased 19.34 13.39 6 84985 12558 29476978
Skin lesion 19.34 13.39 15 84976 18557 29470979
Blindness unilateral 19.25 13.39 37 84954 3737 29485799
Bile duct stenosis 19.17 13.39 20 84971 1140 29488396
Burning sensation 19.12 13.39 11 84980 15927 29473609
Injury 19.07 13.39 16 84975 19030 29470506
Bronchopulmonary aspergillosis 18.82 13.39 6 84985 12338 29477198
Cytokine storm 18.80 13.39 15 84976 602 29488934
Chronic obstructive pulmonary disease 18.67 13.39 58 84933 40897 29448639
Colonic fistula 18.66 13.39 12 84979 341 29489195
Hallucination, visual 18.54 13.39 10 84981 15005 29474531
Tracheal injury 18.49 13.39 5 84986 11 29489525
Multiple organ dysfunction syndrome 18.48 13.39 106 84885 63010 29426526
Gout 18.46 13.39 13 84978 16898 29472638
Product administration error 18.46 13.39 9 84982 14301 29475235
Radiation necrosis 18.38 13.39 8 84983 99 29489437
Retinal artery occlusion 18.37 13.39 23 84968 1600 29487936
Tumour invasion 18.32 13.39 11 84980 276 29489260
Haemoglobin 18.30 13.39 6 84985 31 29489505
Ulcer 18.23 13.39 53 84938 6998 29482538
Bacterial endophthalmitis 18.19 13.39 5 84986 12 29489524
Erectile dysfunction 18.19 13.39 15 84976 17994 29471542
Blood glucose decreased 18.16 13.39 6 84985 12063 29477473
Skin striae 18.06 13.39 13 84978 446 29489090
Oral pain 17.73 13.39 63 84928 9244 29480292
Rash pruritic 17.64 13.39 23 84968 22340 29467196
Haemobilia 17.61 13.39 11 84980 297 29489239
Medication error 17.59 13.39 21 84970 21190 29468346
Intraocular pressure increased 17.52 13.39 41 84950 4748 29484788
Glycosylated haemoglobin increased 17.49 13.39 3 84988 9423 29480113
Injection site swelling 17.47 13.39 3 84988 9414 29480122
Obstructive airways disorder 17.43 13.39 5 84986 11011 29478525
Gastric varices haemorrhage 17.39 13.39 10 84981 231 29489305
Subdural haematoma 17.35 13.39 16 84975 18177 29471359
Cytokine release syndrome 17.30 13.39 8 84983 13111 29476425
Lip swelling 17.27 13.39 7 84984 12403 29477133
Peritoneal neoplasm 17.15 13.39 6 84985 39 29489497
Anger 17.13 13.39 5 84986 10885 29478651
Inappropriate schedule of product administration 16.92 13.39 68 84923 44404 29445132
Urinary retention 16.90 13.39 42 84949 31856 29457680
Type 2 diabetes mellitus 16.83 13.39 9 84982 13572 29475964
Diabetic retinal oedema 16.77 13.39 9 84982 181 29489355
Mean platelet volume decreased 16.69 13.39 12 84979 411 29489125
Stoma site pain 16.64 13.39 13 84978 506 29489030
Oesophageal fistula 16.46 13.39 9 84982 188 29489348
Chest discomfort 16.45 13.39 72 84919 45911 29443625
Nervousness 16.36 13.39 6 84985 11300 29478236
Emotional distress 16.09 13.39 10 84981 13885 29475651
Hepatic enzyme increased 16.03 13.39 47 84944 33752 29455784
Exostosis of jaw 15.91 13.39 7 84984 89 29489447
Cardiogenic shock 15.91 13.39 19 84972 19171 29470365
Jejunal perforation 15.88 13.39 9 84982 202 29489334
Unresponsive to stimuli 15.87 13.39 30 84961 25096 29464440
Pachymeningitis 15.84 13.39 7 84984 90 29489446
Blood pressure decreased 15.79 13.39 72 84919 45405 29444131
Haematemesis 15.77 13.39 123 84868 24503 29465033
Ill-defined disorder 15.77 13.39 71 84920 11607 29477929
Angiogram retina abnormal 15.77 13.39 4 84987 6 29489530
Ocular vascular disorder 15.65 13.39 8 84983 145 29489391
Fear 15.63 13.39 4 84987 9500 29480036
Sudden death 15.61 13.39 81 84910 14029 29475507
Glioblastoma multiforme 15.58 13.39 14 84977 663 29488873
Metastases to abdominal wall 15.57 13.39 6 84985 53 29489483
Head injury 15.50 13.39 14 84977 16067 29473469
Dialysis 15.49 13.39 5 84986 10203 29479333
Pelvic sepsis 15.39 13.39 4 84987 7 29489529
Rectal obstruction 15.39 13.39 4 84987 7 29489529
Full blood count decreased 15.32 13.39 14 84977 15978 29473558
Gastric varices 15.30 13.39 11 84980 377 29489159
Lymphangiosis carcinomatosa 15.25 13.39 15 84976 797 29488739
Oesophageal ulcer 15.20 13.39 30 84961 3090 29486446
Gastroenteritis radiation 15.19 13.39 10 84981 296 29489240
Productive cough 15.17 13.39 43 84948 31216 29458320
Blood creatinine decreased 15.15 13.39 27 84964 2574 29486962
Adverse event 15.12 13.39 13 84978 15278 29474258
Colitis ulcerative 15.05 13.39 9 84982 12760 29476776
Rectal abscess 14.97 13.39 16 84975 938 29488598
Mesenteric vein thrombosis 14.95 13.39 12 84979 486 29489050
Osteoarthritis 14.93 13.39 18 84973 18085 29471451
Product substitution issue 14.82 13.39 4 84987 9168 29480368
Embolism arterial 14.80 13.39 12 84979 493 29489043
Visual field defect 14.80 13.39 35 84956 4081 29485455
Extravasation 14.78 13.39 21 84970 1651 29487885
Primary adrenal insufficiency 14.77 13.39 5 84986 29 29489507
Cholecystitis acute 14.74 13.39 41 84950 5278 29484258
Hepatic atrophy 14.68 13.39 8 84983 166 29489370
Clostridium difficile colitis 14.63 13.39 10 84981 13202 29476334
Portal hypertensive gastropathy 14.60 13.39 12 84979 503 29489033
Palmar erythema 14.57 13.39 9 84982 238 29489298
Arterioenteric fistula 14.57 13.39 3 84988 0 29489536
Alpha 1 foetoprotein decreased 14.57 13.39 3 84988 0 29489536
Ciliary body disorder 14.57 13.39 3 84988 0 29489536
Cyclitis 14.57 13.39 3 84988 0 29489536
Eye pain 14.55 13.39 69 84922 11526 29478010
Incisional hernia 14.44 13.39 17 84974 1109 29488427
Genital herpes zoster 14.44 13.39 4 84987 10 29489526
Abdominal pain lower 14.39 13.39 56 84935 8582 29480954
Surgery 14.31 13.39 8 84983 11771 29477765
Atrophy of globe 14.23 13.39 5 84986 33 29489503
Haptoglobin decreased 14.18 13.39 12 84979 524 29489012
Anorectal infection 14.10 13.39 8 84983 180 29489356
Laboratory test abnormal 14.04 13.39 19 84972 18166 29471370
Cholecystitis 14.02 13.39 58 84933 9139 29480397
Arthritis 14.00 13.39 32 84959 24987 29464549
Hypertensive encephalopathy 14 13.39 10 84981 339 29489197
Pantoea agglomerans infection 13.98 13.39 5 84986 35 29489501
Swollen tongue 13.97 13.39 9 84982 12257 29477279
Intestinal ulcer perforation 13.91 13.39 4 84987 12 29489524
COVID-19 pneumonia 13.87 13.39 5 84986 9517 29480019
Ophthalmological examination abnormal 13.86 13.39 5 84986 36 29489500
Malignant pleural effusion 13.84 13.39 18 84973 1300 29488236
Blood potassium increased 13.83 13.39 13 84978 14638 29474898
Acute myocardial infarction 13.83 13.39 82 84909 48356 29441180
Rectal haemorrhage 13.79 13.39 156 84835 34393 29455143
Tumour pain 13.74 13.39 15 84976 901 29488635
Right ventricular failure 13.61 13.39 3 84988 7887 29481649
Tachypnoea 13.59 13.39 14 84977 15101 29474435
Haematoma 13.56 13.39 29 84962 23183 29466353
Coronary artery occlusion 13.56 13.39 6 84985 10088 29479448
Fingerprint loss 13.51 13.39 5 84986 39 29489497
Peripheral circulatory failure 13.49 13.39 7 84984 131 29489405
Appendicitis noninfective 13.44 13.39 4 84987 14 29489522
Limbic encephalitis 13.43 13.39 10 84981 362 29489174

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 2840.41 12.67 2449 145296 139231 64211756
Proteinuria 1787.30 12.67 987 146758 26736 64324251
Gastrointestinal perforation 1121.19 12.67 434 147311 4990 64345997
Hypertension 1109.68 12.67 2065 145680 257196 64093791
Endophthalmitis 957.34 12.67 386 147359 4979 64346008
Palmar-plantar erythrodysaesthesia syndrome 908.37 12.67 652 147093 28167 64322820
Death 796.14 12.67 2668 145077 480037 63870950
Neuropathy peripheral 739.76 12.67 1114 146631 116411 64234576
Neutrophil count decreased 699.43 12.67 873 146872 76323 64274664
Bone marrow failure 598.75 12.67 640 147105 47312 64303675
Neutropenia 556.91 12.67 1497 146248 238127 64112860
Intestinal perforation 548.99 12.67 375 147370 14938 64336049
Epistaxis 510.70 12.67 853 146892 97278 64253709
Myelosuppression 494.08 12.67 421 147324 23409 64327578
Completed suicide 477.86 12.67 7 147738 224407 64126580
Malignant neoplasm progression 460.18 12.67 882 146863 111989 64238998
Large intestine perforation 454.99 12.67 310 147435 12294 64338693
Drug interaction 438.40 12.67 142 147603 361941 63989046
Neoplasm progression 429.26 12.67 499 147246 40465 64310522
Diarrhoea 425.52 12.67 2967 144778 719737 63631250
Peritonitis 396.46 12.67 380 147365 24643 64326344
Mucosal inflammation 387.33 12.67 589 147156 61995 64288992
Metastases to liver 378.22 12.67 363 147382 23578 64327409
Off label use 376.13 12.67 2605 145140 630201 63720786
Metastases to lung 346.05 12.67 284 147461 14980 64336007
Macular oedema 340.31 12.67 183 147562 4684 64346303
Drug ineffective 338.85 12.67 907 146838 839340 63511647
Neurotoxicity 337.10 12.67 363 147382 27041 64323946
Joint swelling 327.29 12.67 51 147694 215331 64135656
Rheumatoid arthritis 316.71 12.67 14 147731 164280 64186707
Pulmonary embolism 309.38 12.67 884 146861 145472 64205515
Ascites 307.85 12.67 528 147217 61473 64289514
Thrombocytopenia 292.33 12.67 1149 146596 222652 64128335
Suspected transmission of an infectious agent via product 292.08 12.67 101 147644 818 64350169
Intestinal obstruction 288.62 12.67 385 147360 35901 64315086
Anaemia 286.98 12.67 1660 146085 377020 63973967
Posterior reversible encephalopathy syndrome 282.31 12.67 304 147441 22642 64328345
Small intestinal perforation 265.48 12.67 126 147619 2454 64348533
Platelet count decreased 263.33 12.67 914 146831 166797 64184190
Peripheral sensory neuropathy 258.55 12.67 212 147533 11166 64339821
Detachment of retinal pigment epithelium 248.80 12.67 83 147662 595 64350392
Product dose omission issue 243.26 12.67 72 147673 194675 64156312
Visual acuity reduced 234.53 12.67 300 147445 26841 64324146
Condition aggravated 230.29 12.67 310 147435 372116 63978871
Wound dehiscence 230.05 12.67 152 147593 5722 64345265
Decreased appetite 223.26 12.67 1249 146496 280040 64070947
Febrile neutropenia 221.52 12.67 934 146811 186723 64164264
Retinal pigment epithelial tear 220.64 12.67 68 147677 364 64350623
Peripheral swelling 215.19 12.67 105 147640 209048 64141939
Overdose 212.44 12.67 52 147693 159514 64191473
Contraindicated product administered 211.75 12.67 8 147737 107821 64243166
Arthropathy 207.40 12.67 19 147726 120948 64230039
Synovitis 207.00 12.67 4 147741 99086 64251901
Arthralgia 203.91 12.67 444 147301 441816 63909171
Tumour necrosis 202.39 12.67 92 147653 1617 64349370
Protein urine 199.90 12.67 84 147661 1210 64349777
Embolism 197.93 12.67 188 147557 12047 64338940
Dehydration 197.50 12.67 1000 146745 215763 64135224
Interstitial lung disease 197.39 12.67 581 147164 97151 64253836
Vitreous floaters 195.69 12.67 142 147603 6231 64344756
Toxicity to various agents 195.34 12.67 333 147412 363180 63987807
White blood cell count decreased 192.81 12.67 794 146951 157043 64193944
Nephrotic syndrome 188.07 12.67 164 147581 9403 64341584
Metastases to central nervous system 184.77 12.67 192 147553 13720 64337267
Osteonecrosis of jaw 184.43 12.67 329 147416 39496 64311491
Abdominal pain 182.80 12.67 1283 146462 311092 64039895
Injection site pain 181.94 12.67 21 147724 111387 64239600
Polyneuropathy 181.57 12.67 226 147519 19668 64331319
Tumour haemorrhage 181.11 12.67 108 147637 3385 64347602
Drug hypersensitivity 179.61 12.67 168 147577 237647 64113340
Maternal exposure during pregnancy 175.85 12.67 11 147734 95873 64255114
Small intestinal obstruction 173.62 12.67 241 147504 23332 64327655
Therapeutic product effect decreased 173.57 12.67 28 147717 115323 64235664
Stomatitis 172.46 12.67 598 147147 109007 64241980
Ileus 172.46 12.67 237 147508 22729 64328258
Pneumothorax 172.39 12.67 244 147501 24054 64326933
Age-related macular degeneration 171.35 12.67 67 147678 792 64350195
Intentional product use issue 171.16 12.67 544 147201 94820 64256167
Portal hypertension 169.52 12.67 129 147616 6090 64344897
Vomiting 164.54 12.67 1956 145789 549161 63801826
Metastases to meninges 161.67 12.67 93 147652 2722 64348265
Glomerular vascular disorder 159.69 12.67 41 147704 94 64350893
Systemic lupus erythematosus 158.71 12.67 4 147741 77608 64273379
Metastases to peritoneum 156.67 12.67 99 147646 3448 64347539
Rectal perforation 154.15 12.67 60 147685 700 64350287
Musculoskeletal stiffness 152.97 12.67 46 147699 123160 64227827
Exposure during pregnancy 148.38 12.67 7 147738 77668 64273319
Female genital tract fistula 147.83 12.67 86 147659 2572 64348415
Retinal haemorrhage 147.80 12.67 128 147617 7270 64343717
Pruritus 147.67 12.67 309 147436 312091 64038896
Drug intolerance 146.44 12.67 129 147616 187863 64163124
General physical health deterioration 145.29 12.67 882 146863 203543 64147444
Leukopenia 145.27 12.67 536 147209 100706 64250281
Metastases to bone 144.66 12.67 205 147540 20230 64330757
Sinusitis 144.45 12.67 77 147668 145851 64205136
Anastomotic leak 143.54 12.67 61 147684 905 64350082
Pain 143.22 12.67 717 147028 552794 63798193
Tumour perforation 142.01 12.67 46 147699 297 64350690
Fall 140.68 12.67 487 147258 416339 63934648
Gastrointestinal toxicity 139.82 12.67 108 147637 5214 64345773
Nausea 139.05 12.67 2547 145198 783253 63567734
Dizziness 134.37 12.67 519 147226 429644 63921343
Subileus 130.75 12.67 101 147644 4876 64346111
Deep vein thrombosis 130.63 12.67 532 147213 104650 64246337
Intentional product misuse 130.48 12.67 9 147736 72286 64278701
Injection site erythema 130.19 12.67 8 147737 70792 64280195
Asthma 128.73 12.67 30 147715 95195 64255792
Varices oesophageal 128.05 12.67 101 147644 5029 64345958
Thrombotic microangiopathy 125.23 12.67 172 147573 16483 64334504
Suicide attempt 124.84 12.67 10 147735 70997 64279990
Feeling abnormal 124.35 12.67 76 147669 133526 64217461
Vitreous haemorrhage 123.65 12.67 81 147664 3004 64347983
Swelling 123.49 12.67 111 147634 160107 64190880
Necrotising fasciitis 122.60 12.67 100 147645 5226 64345761
Protein urine present 121.45 12.67 125 147620 8831 64342156
Weight increased 120.46 12.67 189 147556 213159 64137828
Hospitalisation 115.99 12.67 17 147728 75190 64275797
Eye inflammation 115.62 12.67 93 147652 4764 64346223
Haematotoxicity 113.69 12.67 144 147601 12752 64338235
Hepatic atrophy 113.62 12.67 41 147704 381 64350606
Suicidal ideation 112.58 12.67 11 147734 66531 64284456
Oesophageal varices haemorrhage 111.74 12.67 81 147664 3548 64347439
Nasal septum perforation 111.60 12.67 47 147698 681 64350306
Abdominal discomfort 111.24 12.67 153 147592 182169 64168818
Cystoid macular oedema 111.03 12.67 62 147683 1712 64349275
Electrocardiogram QT prolonged 109.45 12.67 24 147721 79424 64271563
Rhabdomyolysis 108.96 12.67 37 147708 91689 64259298
Hypertensive crisis 108.95 12.67 169 147576 18079 64332908
Hepatic enzyme increased 106.28 12.67 85 147660 129858 64221129
Carcinoembryonic antigen increased 105.23 12.67 61 147684 1812 64349175
Photopsia 103.27 12.67 86 147659 4628 64346359
Drug reaction with eosinophilia and systemic symptoms 103.18 12.67 5 147740 54212 64296775
Insomnia 102.67 12.67 185 147560 197651 64153336
Skin toxicity 102.16 12.67 99 147646 6503 64344484
Duodenal perforation 101.78 12.67 60 147685 1840 64349147
Constipation 101.30 12.67 883 146862 228454 64122533
Depression 100.97 12.67 165 147580 183126 64167861
Bradycardia 98.36 12.67 76 147669 118143 64232844
Pain in extremity 96.90 12.67 362 147383 302723 64048264
Psoriasis 96.10 12.67 23 147722 71680 64279307
Fistula 95.72 12.67 115 147630 9646 64341341
Hepatic failure 94.81 12.67 311 147434 55083 64295904
Anxiety 93.53 12.67 203 147542 202446 64148541
Venous thrombosis limb 92.46 12.67 74 147671 3763 64347224
Urticaria 91.49 12.67 122 147623 147195 64203792
Dermatitis acneiform 90.31 12.67 104 147641 8339 64342648
Loss of personal independence in daily activities 90.00 12.67 27 147718 72427 64278560
Disseminated intravascular coagulation 89.26 12.67 216 147529 32132 64318855
Vitritis 88.98 12.67 51 147694 1482 64349505
Dysphonia 87.23 12.67 269 147476 46113 64304874
Gastric perforation 87.15 12.67 69 147676 3454 64347533
Ileal perforation 86.84 12.67 42 147703 854 64350133
Psoriatic arthropathy 85.68 12.67 3 147742 43278 64307709
Plasma cell myeloma 85.33 12.67 5 147740 46070 64304917
Hepatic function abnormal 85.20 12.67 332 147413 63981 64287006
Glossodynia 84.29 12.67 22 147723 64674 64286313
Stoma site haemorrhage 83.96 12.67 50 147695 1563 64349424
Hydronephrosis 83.19 12.67 130 147615 13995 64336992
Aortic dissection 81.96 12.67 66 147679 3386 64347601
Suture rupture 81.53 12.67 35 147710 533 64350454
Portal vein thrombosis 79.41 12.67 76 147669 4915 64346072
Wrong technique in product usage process 79.29 12.67 25 147720 64949 64286038
Neoplasm 79.27 12.67 89 147656 6942 64344045
Arthritis 78.92 12.67 47 147698 83767 64267220
Incorrect dose administered 78.52 12.67 21 147724 60744 64290243
Large intestinal obstruction 77.98 12.67 58 147687 2644 64348343
Enterocutaneous fistula 77.77 12.67 47 147698 1510 64349477
Pleural effusion 77.46 12.67 526 147219 126033 64224954
Injury 76.95 12.67 17 147728 55975 64295012
Enteritis 76.54 12.67 115 147630 11962 64339025
Product use issue 75.92 12.67 145 147600 151570 64199417
Venous thrombosis 75.78 12.67 83 147662 6298 64344689
Blindness 75.19 12.67 160 147585 21859 64329128
Suspected counterfeit product 74.86 12.67 32 147713 482 64350505
Cardiac failure congestive 74.30 12.67 115 147630 130465 64220522
Lactic acidosis 74.28 12.67 24 147721 61386 64289601
Somnolence 74.03 12.67 230 147515 203415 64147572
Eastern Cooperative Oncology Group performance status worsened 73.73 12.67 42 147703 1206 64349781
Fistula of small intestine 73.61 12.67 34 147711 621 64350366
Injection site pruritus 73.58 12.67 3 147742 37823 64313164
Retinal detachment 73.40 12.67 91 147654 7885 64343102
Palpitations 72.87 12.67 79 147666 104409 64246578
Influenza 72.69 12.67 82 147663 106449 64244538
Malignant ascites 72.48 12.67 39 147706 999 64349988
Anastomotic complication 72.04 12.67 29 147716 372 64350615
Ciliary hyperaemia 71.88 12.67 19 147726 51 64350936
Bronchitis 71.72 12.67 86 147659 108657 64242330
Tumour rupture 71.45 12.67 28 147717 333 64350654
Haemoptysis 71.42 12.67 261 147484 48787 64302200
Therapy partial responder 71.34 12.67 102 147643 10146 64340841
Blister 71.31 12.67 49 147696 80918 64270069
Treatment failure 70.25 12.67 99 147646 116717 64234270
Hyperammonaemia 69.57 12.67 99 147646 9805 64341182
Wheezing 69.34 12.67 50 147695 80529 64270458
Anastomotic fistula 69.23 12.67 20 147725 82 64350905
Acute abdomen 69.20 12.67 55 147690 2769 64348218
Oesophagobronchial fistula 69.01 12.67 24 147721 198 64350789
Pericarditis 67.94 12.67 29 147716 62487 64288500
Sedation 67.21 12.67 8 147737 41454 64309533
Metastases to lymph nodes 67.01 12.67 91 147654 8626 64342361
Macular hole 66.92 12.67 33 147712 701 64350286
Retinal disorder 66.77 12.67 45 147700 1751 64349236
Lower respiratory tract infection 66.57 12.67 71 147674 94543 64256444
Osteonecrosis 65.94 12.67 177 147568 28052 64322935
Malignant glioma 65.91 12.67 17 147728 40 64350947
Aggression 65.66 12.67 13 147732 46219 64304768
Drug level increased 65.56 12.67 3 147742 34193 64316794
Mobility decreased 65.48 12.67 60 147685 85780 64265207
Urogenital fistula 65.36 12.67 19 147726 80 64350907
Pyrexia 65.14 12.67 1707 146038 556937 63794050
Macular fibrosis 64.80 12.67 32 147713 682 64350305
Product prescribing error 64.79 12.67 4 147741 35265 64315722
Hypopyon 64.50 12.67 36 147709 993 64349994
Increased insulin requirement 64.13 12.67 21 147724 141 64350846
Subretinal fluid 64.02 12.67 31 147714 632 64350355
Red cell distribution width increased 63.92 12.67 107 147638 12202 64338785
Tremor 63.90 12.67 154 147591 148076 64202911
Hypoglycaemia 63.75 12.67 67 147678 89825 64261162
Agitation 63.65 12.67 65 147680 88302 64262685
Abdominal abscess 63.01 12.67 75 147670 6229 64344758
Malignant pleural effusion 62.66 12.67 53 147692 2914 64348073
Carbohydrate antigen 125 increased 61.57 12.67 44 147701 1884 64349103
Irritable bowel syndrome 61.09 12.67 7 147738 37362 64313625
Perforation 60.83 12.67 36 147709 1112 64349875
Helicobacter infection 60.72 12.67 8 147737 38354 64312633
Hallucination 60.27 12.67 47 147698 72741 64278246
Pantoea agglomerans infection 60.20 12.67 17 147728 63 64350924
Treatment noncompliance 60.16 12.67 13 147732 43469 64307518
Hypophosphataemia 59.83 12.67 115 147630 14605 64336382
Nasopharyngitis 59.51 12.67 239 147506 195834 64155153
Osteoporosis 59.41 12.67 12 147733 42068 64308919
Cerebral ischaemia 59.10 12.67 92 147653 9870 64341117
Red blood cell sedimentation rate increased 59.05 12.67 3 147742 31232 64319755
Cholangitis 58.92 12.67 96 147649 10706 64340281
Wound 58.87 12.67 53 147692 76424 64274563
Pseudocirrhosis 58.81 12.67 29 147716 616 64350371
Contusion 58.70 12.67 107 147638 113858 64237129
Pneumatosis intestinalis 58.62 12.67 66 147679 5163 64345824
Macular ischaemia 58.22 12.67 17 147728 73 64350914
COVID-19 57.92 12.67 39 147706 65101 64285886
Eye haemorrhage 57.89 12.67 83 147662 8277 64342710
Eosinophilia 57.80 12.67 9 147736 38067 64312920
Rash 57.71 12.67 723 147022 457826 63893161
Fibromyalgia 57.65 12.67 7 147738 35724 64315263
Tracheal fistula 57.55 12.67 18 147727 102 64350885
Leukoencephalopathy 57.03 12.67 75 147670 6892 64344095
Fluid retention 56.71 12.67 33 147712 59573 64291414
Vitreous detachment 56.71 12.67 42 147703 1902 64349085
Anal fistula 56.68 12.67 65 147680 5188 64345799
Metastatic neoplasm 56.65 12.67 60 147685 4382 64346605
Sleep apnoea syndrome 55.97 12.67 3 147742 29829 64321158
Bacterial endophthalmitis 55.82 12.67 14 147731 28 64350959
Mycotic endophthalmitis 55.63 12.67 17 147728 88 64350899
Lymphocyte count decreased 55.44 12.67 212 147533 40487 64310500
Psychotic disorder 55.24 12.67 7 147738 34571 64316416
Drug dependence 55.07 12.67 6 147739 33306 64317681
Asthenia 54.87 12.67 1325 146420 426719 63924268
Blood cholesterol increased 54.76 12.67 23 147722 50043 64300944
Gastrointestinal anastomotic leak 54.61 12.67 24 147721 388 64350599
Immune thrombocytopenia 54.38 12.67 112 147633 14954 64336033
Injection site bruising 54.31 12.67 9 147736 36364 64314623
Metastasis 54.06 12.67 66 147679 5629 64345358
Coma 53.92 12.67 73 147672 87542 64263445
Chronic obstructive pulmonary disease 53.78 12.67 50 147695 70998 64279989
Toxic epidermal necrolysis 53.74 12.67 10 147735 37156 64313831
Diabetes mellitus 53.69 12.67 44 147701 66430 64284557
Angioedema 53.66 12.67 38 147707 61783 64289204
Laryngeal necrosis 53.61 12.67 13 147732 21 64350966
Hypotension 53.59 12.67 586 147159 380388 63970599
Drug withdrawal syndrome 53.38 12.67 5 147740 31286 64319701
Paronychia 53.32 12.67 70 147675 6422 64344565
Accidental overdose 53.11 12.67 7 147738 33550 64317437
Cataract nuclear 53.02 12.67 31 147714 936 64350051
Colitis 52.81 12.67 270 147475 58404 64292583
Failure to anastomose 52.76 12.67 20 147725 216 64350771
Lymphangiosis carcinomatosa 52.35 12.67 39 147706 1782 64349205
Respiratory arrest 52.33 12.67 28 147717 52957 64298030
Proctalgia 52.27 12.67 75 147670 7484 64343503
Mean cell volume increased 52.04 12.67 61 147684 4985 64346002
Nail toxicity 51.31 12.67 22 147723 334 64350653
Osteoarthritis 51.05 12.67 42 147703 63294 64287693
Enterovesical fistula 50.98 12.67 30 147715 917 64350070
Gastrointestinal necrosis 50.90 12.67 60 147685 4932 64346055
Tumour marker increased 50.15 12.67 50 147695 3400 64347587
Muscle spasms 50.01 12.67 161 147584 140862 64210125
Retinal oedema 49.92 12.67 28 147717 780 64350207
Pneumonitis 49.76 12.67 238 147507 50127 64300860
Retinal vascular disorder 49.23 12.67 20 147725 263 64350724
Pulmonary haemorrhage 49.15 12.67 99 147646 13010 64337977
Magnetic resonance imaging head abnormal 48.72 12.67 42 147703 2370 64348617
Metamorphopsia 48.51 12.67 31 147714 1101 64349886
Dyskinesia 48.33 12.67 15 147730 39373 64311614
Discomfort 48.16 12.67 69 147676 80809 64270178
Hemiparesis 47.96 12.67 164 147581 29663 64321324
Mean cell haemoglobin increased 47.64 12.67 47 147698 3155 64347832
Stomal varices 47.40 12.67 13 147732 42 64350945
Cardiac arrest 47.24 12.67 187 147558 153877 64197110
Hypertensive encephalopathy 47.11 12.67 28 147717 872 64350115
Irritability 46.91 12.67 13 147732 36733 64314254
Adverse event 46.76 12.67 16 147729 39473 64311514
Gait disturbance 46.65 12.67 219 147526 171936 64179051
Hypomagnesaemia 46.32 12.67 189 147556 37187 64313800
Retinal exudates 45.62 12.67 30 147715 1120 64349867
Device related infection 45.45 12.67 164 147581 30462 64320525
Tumour ulceration 45.31 12.67 17 147728 178 64350809
Superior vena cava syndrome 44.98 12.67 29 147716 1046 64349941
Headache 44.98 12.67 899 146846 528568 63822419
Rectal haemorrhage 44.63 12.67 268 147477 61549 64289438
Underdose 44.40 12.67 4 147741 25825 64325162
Pulmonary artery thrombosis 44.32 12.67 30 147715 1176 64349811
Medication error 44.31 12.67 30 147715 49936 64301051
Injection site reaction 44.16 12.67 26 147719 46638 64304349
Anterior chamber inflammation 44.12 12.67 22 147723 479 64350508
Coronary artery disease 44.03 12.67 44 147701 60389 64290598
Retinal artery occlusion 43.92 12.67 43 147702 2860 64348127
Burning sensation 43.80 12.67 30 147715 49634 64301353
Type 2 diabetes mellitus 43.49 12.67 12 147733 34008 64316979
Incisional hernia 43.45 12.67 37 147708 2053 64348934
Dry throat 43.34 12.67 62 147683 6170 64344817
Swelling face 43.20 12.67 43 147702 59123 64291864
Blood bilirubin increased 43.15 12.67 252 147493 57301 64293686
Colorectal cancer metastatic 42.91 12.67 27 147718 933 64350054
Performance status decreased 42.76 12.67 57 147688 5307 64345680
Acute kidney injury 42.72 12.67 748 146997 448492 63902495
Mechanical ileus 42.61 12.67 23 147722 593 64350394
Acral peeling skin syndrome 42.59 12.67 12 147733 44 64350943
Throat tightness 42.31 12.67 133 147612 23027 64327960
Stress 41.94 12.67 46 147699 60488 64290499
Arteriospasm coronary 41.93 12.67 57 147688 5408 64345579
Wound infection 41.80 12.67 100 147645 14764 64336223
Perirectal abscess 41.64 12.67 34 147711 1779 64349208
Peritoneal disorder 41.49 12.67 23 147722 626 64350361
Thrombophlebitis migrans 41.18 12.67 18 147727 287 64350700
Pelvic abscess 41.12 12.67 34 147711 1811 64349176
Myalgia 41.10 12.67 205 147540 158412 64192575
Product use in unapproved indication 40.93 12.67 237 147508 176381 64174606
Cytomegalovirus infection 40.82 12.67 17 147728 37182 64313805
Inappropriate schedule of product administration 40.46 12.67 95 147650 92191 64258796
Hypoalbuminaemia 40.45 12.67 110 147635 17564 64333423
Haemoglobin 40.39 12.67 13 147732 82 64350905
Myoclonus 40.33 12.67 5 147740 25113 64325874
Colon cancer metastatic 39.89 12.67 34 147711 1889 64349098
Migraine 39.82 12.67 51 147694 62626 64288361
Hypervolaemia 39.65 12.67 19 147726 38266 64312721
Respiratory depression 39.32 12.67 4 147741 23439 64327548
Cerebral infarction 39.14 12.67 192 147553 40852 64310135
Ureteric compression 39.08 12.67 15 147730 168 64350819
Pulpitis dental 39.01 12.67 26 147719 993 64349994
Ovarian cancer recurrent 38.86 12.67 18 147727 331 64350656
Therapy cessation 38.75 12.67 13 147732 32476 64318511
Impaired healing 38.57 12.67 254 147491 60219 64290768
Metastases to pleura 38.43 12.67 28 147717 1236 64349751
Haemorrhage 38.39 12.67 312 147433 79039 64271948
Fatigue 38.16 12.67 2087 145658 746643 63604344
Angiogram retina abnormal 38.13 12.67 9 147736 12 64350975
Hypokalaemia 38.04 12.67 437 147308 121466 64229521
Vitreous opacities 38.01 12.67 20 147725 489 64350498
Ejection fraction decreased 37.84 12.67 148 147597 28559 64322428
Abnormal behaviour 37.49 12.67 15 147730 33607 64317380
Left ventricular dysfunction 37.30 12.67 104 147641 16850 64334137
Emotional distress 37.15 12.67 18 147727 36020 64314967
Cystitis radiation 37.09 12.67 13 147732 110 64350877
Metabolic acidosis 37.09 12.67 66 147679 70892 64280095
Glioblastoma 36.97 12.67 29 147716 1432 64349555
Adverse drug reaction 36.82 12.67 30 147715 45434 64305553
Loss of consciousness 36.60 12.67 195 147550 148170 64202817
Nasal congestion 36.41 12.67 50 147695 59608 64291379
Abortion spontaneous 35.85 12.67 7 147738 25136 64325851
Bleeding varicose vein 35.84 12.67 19 147726 472 64350515
Basal cell carcinoma 35.65 12.67 13 147732 30825 64320162
Retinal degeneration 35.58 12.67 25 147720 1042 64349945
Cyclitis 35.57 12.67 7 147738 0 64350987
Intracranial tumour haemorrhage 35.36 12.67 18 147727 410 64350577
Choroidal neovascularisation 35.36 12.67 18 147727 410 64350577
Prescribed overdose 35.35 12.67 3 147742 20328 64330659
Device issue 35.19 12.67 5 147740 22643 64328344
Intraocular pressure increased 35.15 12.67 66 147679 8236 64342751
Rash pruritic 35.15 12.67 48 147697 57356 64293631
Bronchial fistula 35.10 12.67 14 147731 175 64350812
Enterocolitis 35.04 12.67 82 147663 11936 64339051
Joint stiffness 34.84 12.67 13 147732 30391 64320596
Pneumonia 34.82 12.67 996 146749 558580 63792407
Non-infectious endophthalmitis 34.80 12.67 16 147729 289 64350698
Therapeutic product effect incomplete 34.05 12.67 122 147623 103360 64247627
Oesophagitis 33.96 12.67 118 147627 21512 64329475
Pregnancy 33.88 12.67 4 147741 20861 64330126
Swollen tongue 33.75 12.67 19 147726 34935 64316052
Extravasation 33.72 12.67 39 147706 3141 64347846
Intestinal metastasis 33.72 12.67 15 147730 250 64350737
Cholecystitis acute 33.66 12.67 78 147667 11282 64339705
Splenomegaly 33.60 12.67 104 147641 17857 64333130
Eczema 33.57 12.67 13 147732 29707 64321280
Radiation necrosis 33.50 12.67 16 147729 316 64350671
Ureteric fistula 33.35 12.67 8 147737 12 64350975
Neutropenic sepsis 33.16 12.67 123 147622 23149 64327838
Blood pressure fluctuation 33.16 12.67 42 147703 51829 64299158
Rectourethral fistula 33.08 12.67 7 147738 3 64350984
Unresponsive to stimuli 33.06 12.67 40 147705 50353 64300634
Eye discharge 33.06 12.67 49 147696 5035 64345952
Mucosal toxicity 33.00 12.67 18 147727 474 64350513
Blindness unilateral 32.77 12.67 57 147688 6704 64344283
Upper respiratory tract infection 32.65 12.67 74 147671 72711 64278276
Anaemia of malignant disease 32.56 12.67 20 147725 662 64350325
Dysaesthesia 32.28 12.67 48 147697 4947 64346040
Microangiopathic haemolytic anaemia 32.25 12.67 26 147719 1336 64349651
Anal haemorrhage 32.18 12.67 39 147706 3301 64347686
Therapy interrupted 32.14 12.67 4 147741 20032 64330955
Therapy responder 32.00 12.67 17 147728 424 64350563
Transmission of an infectious agent via product 31.73 12.67 13 147732 175 64350812
Nervousness 31.65 12.67 14 147731 29542 64321445
Illness 31.51 12.67 6 147739 21932 64329055
Lip swelling 31.31 12.67 17 147728 31890 64319097
Macular scar 31.29 12.67 11 147734 94 64350893
Uveitis 31.01 12.67 81 147664 12627 64338360
Memory impairment 30.94 12.67 97 147648 85585 64265402
Right ventricular failure 30.57 12.67 6 147739 21465 64329522
Subretinal fibrosis 30.53 12.67 12 147733 144 64350843
Ear infection 30.40 12.67 8 147737 23396 64327591
Transfusion 30.36 12.67 3 147742 17991 64332996
Hip arthroplasty 30.33 12.67 6 147739 21345 64329642
Arterioenteric fistula 30.25 12.67 7 147738 8 64350979
Acute myeloid leukaemia 30.25 12.67 134 147611 27329 64323658
Pneumoperitoneum 30.02 12.67 34 147711 2677 64348310
Myocardial infarction 29.72 12.67 240 147505 165581 64185406
Labelled drug-drug interaction medication error 29.71 12.67 7 147738 22055 64328932
Joint injury 29.51 12.67 8 147737 22939 64328048
Gastric disorder 29.47 12.67 15 147730 29182 64321805
Hyperhidrosis 29.27 12.67 167 147578 124753 64226234
Melanoderma 29.18 12.67 15 147730 349 64350638
Obesity 28.74 12.67 6 147739 20556 64330431
Lacrimation increased 28.73 12.67 100 147645 18246 64332741
Neoplasm recurrence 28.69 12.67 39 147706 3700 64347287
Drug ineffective for unapproved indication 28.54 12.67 18 147727 31115 64319872
Oesophageal fistula 28.41 12.67 14 147731 297 64350690
Peritoneal neoplasm 28.39 12.67 10 147735 86 64350901
Vaginal fistula 28.37 12.67 13 147732 233 64350754
Colitis ischaemic 28.25 12.67 81 147664 13333 64337654
Blood glucose increased 28.20 12.67 122 147623 97951 64253036
Thrombosis 28.06 12.67 266 147479 70376 64280611
Retinal scar 27.99 12.67 15 147730 381 64350606
Urinary tract obstruction 27.99 12.67 40 147705 3977 64347010
Cardio-respiratory arrest 27.93 12.67 123 147622 98270 64252717
Road traffic accident 27.88 12.67 18 147727 30727 64320260
Product contamination microbial 27.85 12.67 20 147725 863 64350124
Crying 27.80 12.67 6 147739 20084 64330903
Herpes zoster 27.65 12.67 91 147654 79096 64271891
Ovarian cancer metastatic 27.64 12.67 16 147729 474 64350513
Product substitution issue 27.62 12.67 4 147741 17857 64333130
Embolism venous 27.55 12.67 37 147708 3470 64347517
Dystonia 27.44 12.67 5 147740 18860 64332127
Granulocyte count decreased 27.37 12.67 23 147722 1253 64349734
Gastrooesophageal reflux disease 27.37 12.67 98 147647 83045 64267942
Atypical haemolytic uraemic syndrome 27.32 12.67 18 147727 674 64350313
Unevaluable event 27.26 12.67 46 147699 50443 64300544
Stevens-Johnson syndrome 27.24 12.67 23 147722 34226 64316761
Foot deformity 27.21 12.67 3 147742 16501 64334486
Gastric varices haemorrhage 27.11 12.67 14 147731 329 64350658
Anal fissure 27.10 12.67 44 147701 4892 64346095
Vena cava thrombosis 26.96 12.67 31 147714 2481 64348506
Retinal vascular occlusion 26.64 12.67 16 147729 508 64350479
Hiccups 26.47 12.67 59 147686 8317 64342670
Obstructive airways disorder 26.42 12.67 10 147735 23175 64327812
Glycosylated haemoglobin increased 26.19 12.67 3 147742 16016 64334971
Abdominal infection 26.18 12.67 33 147712 2907 64348080
Sciatica 26.18 12.67 7 147738 20257 64330730
Thrombotic thrombocytopenic purpura 25.87 12.67 48 147697 5936 64345051
Proctitis 25.85 12.67 34 147711 3125 64347862
Colonic fistula 25.79 12.67 16 147729 539 64350448
Bladder perforation 25.75 12.67 13 147732 291 64350696
Varicose vein ruptured 25.70 12.67 9 147736 76 64350911
Cardiac disorder 25.64 12.67 56 147689 55760 64295227
Pseudoendophthalmitis 25.63 12.67 8 147737 45 64350942
Biliary fistula 25.49 12.67 9 147736 78 64350909
Injection related reaction 25.49 12.67 17 147728 650 64350337
Duodenal ulcer perforation 25.46 12.67 25 147720 34600 64316387
Diverticular perforation 25.33 12.67 44 147701 5169 64345818
Infectious pleural effusion 25.29 12.67 32 147713 2830 64348157
Prostate cancer 25.27 12.67 7 147738 19788 64331199
Ocular discomfort 25.23 12.67 38 147707 3961 64347026
Retinal aneurysm 25.17 12.67 12 147733 236 64350751
Procedural pain 25.11 12.67 3 147742 15505 64335482
Venous pressure jugular decreased 25.10 12.67 9 147736 82 64350905
Hypophagia 25.07 12.67 166 147579 39421 64311566
Productive cough 24.96 12.67 85 147660 73118 64277869
Surgery 24.93 12.67 17 147728 28196 64322791
Ventricular tachycardia 24.90 12.67 25 147720 34240 64316747
Hyperammonaemic encephalopathy 24.80 12.67 38 147707 4020 64346967
Mood swings 24.62 12.67 5 147740 17463 64333524
Venoocclusive liver disease 24.61 12.67 64 147681 9951 64341036
Anterior chamber cell 24.48 12.67 18 147727 806 64350181
Depressed mood 24.40 12.67 35 147710 40977 64310010
Peripheral motor neuropathy 24.35 12.67 32 147713 2938 64348049
Toxic anterior segment syndrome 24.35 12.67 29 147716 2410 64348577
Adenocarcinoma 24.28 12.67 34 147711 3317 64347670
Proteus infection 24.23 12.67 24 147721 1619 64349368
Short-bowel syndrome 24.21 12.67 14 147731 414 64350573
Chest discomfort 24.19 12.67 161 147584 115945 64235042
Cutis laxa 24.12 12.67 10 147735 139 64350848
Neutropenic infection 24.10 12.67 26 147719 1939 64349048
Fingerprint loss 24.02 12.67 8 147737 57 64350930
Diabetic retinopathy 23.92 12.67 31 147714 2808 64348179
Immune-mediated hepatitis 23.87 12.67 29 147716 2460 64348527
Anal ulcer 23.81 12.67 20 147725 1089 64349898
Gastrointestinal fistula 23.78 12.67 16 147729 621 64350366
Prescribed underdose 23.70 12.67 6 147739 18009 64332978
Gastropleural fistula 23.67 12.67 8 147737 60 64350927
Laryngospasm 23.55 12.67 34 147711 3411 64347576
Disturbance in attention 23.51 12.67 36 147709 41038 64309949
Tachyphylaxis 23.51 12.67 12 147733 275 64350712
Mental disorder 23.28 12.67 16 147729 26429 64324558
Limb discomfort 23.19 12.67 17 147728 27158 64323829
Vascular pseudoaneurysm 23.09 12.67 32 147713 3092 64347895
Liver function test abnormal 23.07 12.67 65 147680 59336 64291651
Muscle spasticity 23.02 12.67 5 147740 16664 64334323
Extrapyramidal disorder 23.01 12.67 8 147737 19544 64331443
Hallucination, visual 23 12.67 18 147727 27816 64323171
Device malfunction 22.95 12.67 6 147739 17627 64333360
Type II hypersensitivity 22.94 12.67 7 147738 36 64350951
Device related thrombosis 22.83 12.67 26 147719 2059 64348928
BRCA2 gene mutation 22.69 12.67 8 147737 69 64350918
Onycholysis 22.60 12.67 23 147722 1603 64349384
Tooth erosion 22.55 12.67 13 147732 382 64350605
Blood pressure decreased 22.55 12.67 111 147634 86088 64264899
Pelvic infection 22.53 12.67 12 147733 301 64350686
Throat irritation 22.50 12.67 25 147720 32686 64318301
Nephrolithiasis 22.49 12.67 41 147704 43642 64307345
Fear 22.49 12.67 9 147736 20162 64330825
Progressive multifocal leukoencephalopathy 22.27 12.67 7 147738 18225 64332762
Iridocyclitis 22.22 12.67 31 147714 3014 64347973
Metastases to abdominal wall 22.18 12.67 9 147736 118 64350869
Bronchopulmonary aspergillosis 22.14 12.67 8 147737 19077 64331910
Duodenal ulcer 22.01 12.67 78 147667 14357 64336630
Pyelocaliectasis 22.00 12.67 17 147728 821 64350166
Acute coronary syndrome 21.86 12.67 95 147650 19215 64331772
Delusion 21.85 12.67 7 147738 18007 64332980
Accidental exposure to product 21.85 12.67 17 147728 26347 64324640
International normalised ratio increased 21.84 12.67 100 147645 79067 64271920
Folliculitis 21.79 12.67 22 147723 30055 64320932
Gallbladder disorder 21.78 12.67 6 147739 17024 64333963
Catheter site injury 21.78 12.67 9 147736 124 64350863
Retinal neovascularisation 21.71 12.67 9 147736 125 64350862
Metastases to ovary 21.59 12.67 11 147734 251 64350736
Hot flush 21.56 12.67 46 147699 46189 64304798
Kidney infection 21.52 12.67 7 147738 17831 64333156
Incarcerated incisional hernia 21.51 12.67 6 147739 21 64350966
Wound complication 21.41 12.67 35 147710 3913 64347074
Mean platelet volume decreased 21.40 12.67 23 147722 1708 64349279
Haematocrit decreased 21.31 12.67 205 147540 54450 64296537
Skin striae 21.30 12.67 21 147724 1409 64349578
Polychromasia 21.28 12.67 11 147734 259 64350728
Neck pain 21.28 12.67 71 147674 61462 64289525
Perihepatic abscess 21.21 12.67 9 147736 133 64350854
Retinal vein occlusion 21.18 12.67 30 147715 2958 64348029
Ankle fracture 21.17 12.67 4 147741 14706 64336281
Paraesthesia 21.15 12.67 429 147316 134093 64216894
Tumour invasion 21.11 12.67 12 147733 343 64350644
Lower limb fracture 21.02 12.67 3 147742 13542 64337445
Dysaesthesia pharynx 21.01 12.67 10 147735 196 64350791
Anorectal disorder 20.93 12.67 24 147721 1915 64349072
Anorectal infection 20.90 12.67 12 147733 350 64350637
Localised infection 20.80 12.67 23 147722 30138 64320849
Panic attack 20.80 12.67 11 147734 20942 64330045
Dysgeusia 20.64 12.67 181 147564 46866 64304121
Metastases to adrenals 20.63 12.67 19 147726 1170 64349817
Prothrombin level decreased 20.62 12.67 21 147724 1465 64349522
Torsade de pointes 20.62 12.67 7 147738 17356 64333631
Fungal infection 20.60 12.67 29 147716 34222 64316765
Head injury 20.57 12.67 27 147718 32815 64318172
Delirium 20.56 12.67 85 147660 69109 64281878
Haemolytic anaemia 20.54 12.67 82 147663 15971 64335016
Parkinsonism 20.50 12.67 4 147741 14369 64336618
Carbohydrate antigen 19-9 increased 20.38 12.67 12 147733 367 64350620
Soft tissue necrosis 20.37 12.67 15 147730 673 64350314
Splenic artery thrombosis 20.32 12.67 7 147738 56 64350931
Abdominal hernia 20.27 12.67 39 147706 4956 64346031
Skin ulcer 20.24 12.67 171 147574 43803 64307184
Pulmonary cavitation 20.24 12.67 20 147725 1345 64349642
Microangiopathy 20.21 12.67 21 147724 1500 64349487
Colitis ulcerative 20.18 12.67 14 147731 23014 64327973
Oropharyngeal pain 20.17 12.67 120 147625 88747 64262240
Respiratory tract congestion 20.11 12.67 6 147739 16159 64334828
Febrile bone marrow aplasia 19.98 12.67 64 147681 11191 64339796
Cellulitis 19.94 12.67 129 147616 93528 64257459
Gingival bleeding 19.92 12.67 77 147668 14777 64336210
Pemphigoid 19.87 12.67 3 147742 12983 64338004
Visual impairment 19.82 12.67 258 147487 73819 64277168
Hallucination, auditory 19.82 12.67 7 147738 16932 64334055
Metastases to abdominal cavity 19.70 12.67 13 147732 488 64350499
Tongue geographic 19.69 12.67 7 147738 62 64350925
Epilepsy 19.68 12.67 138 147607 33393 64317594
Iron deficiency anaemia 19.60 12.67 13 147732 21876 64329111
Ophthalmological examination abnormal 19.60 12.67 7 147738 63 64350924
Joint range of motion decreased 19.43 12.67 10 147735 19333 64331654
Anger 19.30 12.67 6 147739 15735 64335252
Pelvic venous thrombosis 19.23 12.67 22 147723 1751 64349236
Polyuria 19.16 12.67 3 147742 12640 64338347
Anhedonia 19.16 12.67 4 147741 13702 64337285
Cytokine release syndrome 19.15 12.67 12 147733 20817 64330170
Bladder tamponade 19.10 12.67 13 147732 514 64350473
Charles Bonnet syndrome 19.03 12.67 5 147740 13 64350974
Choroidal infarction 19.02 12.67 9 147736 174 64350813
Pulmonary arterial hypertension 19.02 12.67 18 147727 25349 64325638
Blindness transient 19.00 12.67 34 147711 4088 64346899
Ulcerative keratitis 18.93 12.67 29 147716 3068 64347919
Hypercreatinaemia 18.84 12.67 10 147735 249 64350738
No adverse event 18.84 12.67 121 147624 28440 64322547
Influenza like illness 18.83 12.67 75 147670 61627 64289360
Blood potassium increased 18.82 12.67 19 147726 25961 64325026
Hypersplenism 18.81 12.67 12 147733 425 64350562
Hyperlipidaemia 18.81 12.67 15 147730 22961 64328026
Gout 18.79 12.67 13 147732 21400 64329587
Periodontitis 18.79 12.67 34 147711 4125 64346862
Tumour cavitation 18.76 12.67 5 147740 14 64350973
Rash macular 18.72 12.67 16 147729 23669 64327318
Induration 18.65 12.67 21 147724 1643 64349344
Tachypnoea 18.61 12.67 20 147725 26551 64324436
Creatinine renal clearance decreased 18.60 12.67 5 147740 14416 64336571
Rectal cancer metastatic 18.51 12.67 12 147733 437 64350550
Duodenal varices 18.51 12.67 5 147740 15 64350972
Restless legs syndrome 18.50 12.67 8 147737 17108 64333879
Lactobacillus infection 18.43 12.67 9 147736 187 64350800
Device dislocation 18.40 12.67 13 147732 21165 64329822
Therapeutic response unexpected 18.29 12.67 8 147737 16993 64333994
Metastases to vagina 18.27 12.67 5 147740 16 64350971
Restlessness 18.21 12.67 40 147705 39745 64311242
Rectal ulcer 18.20 12.67 22 147723 1857 64349130
Abscess 18.19 12.67 90 147655 19214 64331773
Metastases to kidney 18.17 12.67 12 147733 451 64350536
Radiation oesophagitis 18.16 12.67 13 147732 558 64350429
Skin lesion 18.12 12.67 35 147710 36447 64314540
Peripheral paralysis 18.11 12.67 8 147737 131 64350856
Full blood count abnormal 18.09 12.67 25 147720 29732 64321255
Biliary tract disorder 18.09 12.67 19 147726 1374 64349613
Rectal abscess 18.05 12.67 20 147725 1537 64349450
Appendicitis noninfective 18.04 12.67 5 147740 17 64350970
Vitreous adhesions 17.99 12.67 6 147739 43 64350944
Sleep disorder 17.95 12.67 73 147672 59636 64291351
Hypothyroidism 17.93 12.67 156 147589 40301 64310686
Acute generalised exanthematous pustulosis 17.89 12.67 5 147740 14053 64336934
Tuberculosis 17.83 12.67 4 147741 13034 64337953
Ocular hypertension 17.82 12.67 18 147727 1243 64349744
Blood glucose decreased 17.82 12.67 16 147729 23107 64327880
Chemotherapy cardiotoxicity attenuation 17.82 12.67 5 147740 18 64350969
Conjunctival hyperaemia 17.77 12.67 32 147713 3867 64347120
Oesophageal haemorrhage 17.77 12.67 20 147725 1564 64349423
Hypermutation 17.75 12.67 6 147739 45 64350942
Hiatus hernia 17.67 12.67 12 147733 19945 64331042
Retinal ischaemia 17.59 12.67 14 147731 706 64350281
Coronary artery occlusion 17.57 12.67 5 147740 13886 64337101
Hypokinesia 17.55 12.67 8 147737 16588 64334399
Glomerulonephropathy 17.47 12.67 10 147735 290 64350697
Bile duct stenosis 17.46 12.67 21 147724 1763 64349224
Bronchopleural fistula 17.39 12.67 13 147732 597 64350390
COVID-19 pneumonia 17.38 12.67 8 147737 16496 64334491
Foot fracture 17.34 12.67 10 147735 18147 64332840
Secondary cerebellar degeneration 17.31 12.67 6 147739 49 64350938
Seasonal allergy 17.29 12.67 3 147742 11723 64339264
Hepatic lesion 17.27 12.67 40 147705 5784 64345203
Infected lymphocele 17.22 12.67 9 147736 217 64350770
Rectal cancer recurrent 17.21 12.67 5 147740 21 64350966
Amnesia 17.17 12.67 55 147690 48214 64302773
Blood triglycerides increased 17.17 12.67 11 147734 18855 64332132
Inferior vena cava stenosis 17.10 12.67 6 147739 51 64350936
Mental impairment 17.09 12.67 8 147737 16335 64334652
Cardiogenic shock 17.09 12.67 30 147715 32397 64318590
Haemolytic uraemic syndrome 17.06 12.67 32 147713 3989 64346998
Sudden death 17.06 12.67 91 147654 20005 64330982
Periphlebitis 17.03 12.67 5 147740 22 64350965
Tumour obstruction 17.03 12.67 5 147740 22 64350965
Cancer pain 16.98 12.67 33 147712 4224 64346763
Oedema peripheral 16.93 12.67 360 147385 209957 64141030
Incorrect route of product administration 16.92 12.67 17 147728 23281 64327706
Concomitant disease aggravated 16.91 12.67 3 147742 11539 64339448
Jejunal perforation 16.89 12.67 10 147735 309 64350678
Necrosis 16.88 12.67 49 147696 8122 64342865
Blood pressure increased 16.86 12.67 516 147229 172036 64178951
Retinal depigmentation 16.81 12.67 10 147735 312 64350675
Dysstasia 16.80 12.67 17 147728 23198 64327789
Aortic thrombosis 16.79 12.67 19 147726 1495 64349492
Respiratory disorder 16.78 12.67 36 147709 36075 64314912
Eye pain 16.75 12.67 127 147618 31498 64319489
Optic neuropathy 16.75 12.67 27 147718 2984 64348003
Congestive cardiomyopathy 16.73 12.67 57 147688 10287 64340700
Metastases to spine 16.73 12.67 30 147715 3613 64347374
Posterior capsule opacification 16.71 12.67 8 147737 159 64350828
Periodontal disease 16.71 12.67 20 147725 1671 64349316
Exostosis 16.70 12.67 3 147742 11435 64339552
Laryngeal leukoplakia 16.70 12.67 6 147739 55 64350932
Macular degeneration 16.69 12.67 39 147706 5671 64345316
Tooth disorder 16.67 12.67 16 147729 22386 64328601
Subdural haematoma 16.63 12.67 24 147721 28030 64322957
Iris neovascularisation 16.60 12.67 6 147739 56 64350931
Oxygen saturation decreased 16.60 12.67 161 147584 107015 64243972
Anal abscess 16.46 12.67 46 147699 7462 64343525
Neutrophil count 16.39 12.67 8 147737 166 64350821
Intestinal fistula 16.39 12.67 17 147728 1212 64349775
Vitreous disorder 16.37 12.67 9 147736 241 64350746
Acute respiratory failure 16.33 12.67 59 147686 49875 64301112
Abdominal wound dehiscence 16.33 12.67 9 147736 242 64350745
Atrophy of globe 16.33 12.67 6 147739 59 64350928
Pelvic neoplasm 16.28 12.67 7 147738 107 64350880
Limb injury 16.12 12.67 18 147727 23487 64327500
Vascular access complication 16.12 12.67 16 147729 1082 64349905
Disability 16.12 12.67 4 147741 12168 64338819
Retinopathy proliferative 16.05 12.67 7 147738 111 64350876
Product administration error 16.04 12.67 24 147721 27619 64323368
Visual field defect 16.02 12.67 48 147697 8098 64342889
Gastroenteritis viral 16.00 12.67 13 147732 19716 64331271
Photosensitivity reaction 15.99 12.67 11 147734 18162 64332825
Lymphoma 15.91 12.67 6 147739 13935 64337052
Vitreous degeneration 15.89 12.67 5 147740 29 64350958
Spinal stenosis 15.89 12.67 6 147739 13925 64337062
Intracranial hypotension 15.88 12.67 10 147735 346 64350641
Birdshot chorioretinopathy 15.81 12.67 6 147739 65 64350922
Hypertriglyceridaemia 15.78 12.67 59 147686 11146 64339841
Aphasia 15.73 12.67 153 147592 40753 64310234
EGFR gene mutation 15.68 12.67 10 147735 354 64350633
Retinal fibrosis 15.63 12.67 4 147741 9 64350978
Confusional state 15.63 12.67 467 147278 260677 64090310
Pulmonary congestion 15.61 12.67 19 147726 23861 64327126
Thyroiditis 15.58 12.67 29 147716 3595 64347392
Blood creatine phosphokinase increased 15.55 12.67 75 147670 58483 64292504
Rash papular 15.54 12.67 10 147735 17103 64333884
Intravascular haemolysis 15.49 12.67 13 147732 707 64350280
Post procedural bile leak 15.43 12.67 10 147735 364 64350623
Pulmonary fibrosis 15.42 12.67 28 147717 29850 64321137
Aneurysm ruptured 15.38 12.67 14 147731 849 64350138
Diabetic ketoacidosis 15.38 12.67 28 147717 29817 64321170
Implant site dehiscence 15.34 12.67 5 147740 33 64350954
Atrioventricular block first degree 15.28 12.67 3 147742 10731 64340256
Taste disorder 15.28 12.67 52 147693 9381 64341606
Cytoreductive surgery 15.24 12.67 3 147742 0 64350987
Serous cystadenocarcinoma ovary 15.24 12.67 3 147742 0 64350987
Metastases to rectum 15.24 12.67 3 147742 0 64350987
Superior vena cava stenosis 15.24 12.67 3 147742 0 64350987
Eastern Cooperative Oncology Group performance status improved 15.24 12.67 3 147742 0 64350987
Choroidal rupture 15.24 12.67 3 147742 0 64350987
Instillation site complication 15.24 12.67 3 147742 0 64350987
Alpha 1 foetoprotein decreased 15.24 12.67 3 147742 0 64350987
Immunodeficiency 15.23 12.67 9 147736 16115 64334872
Skin hyperpigmentation 15.22 12.67 41 147704 6510 64344477
Viral infection 15.20 12.67 38 147707 36102 64314885
Sneezing 15.15 12.67 8 147737 15243 64335744
Bacteroides infection 15.12 12.67 9 147736 281 64350706
Disorientation 15.12 12.67 71 147674 55757 64295230
Drug effective for unapproved indication 15.11 12.67 29 147716 3679 64347308
Brachiocephalic vein thrombosis 15.10 12.67 7 147738 129 64350858
Duodenal obstruction 15.07 12.67 10 147735 379 64350608
Peritumoural oedema 15.06 12.67 4 147741 11 64350976
Diaphragmatic paralysis 15.06 12.67 15 147730 1019 64349968
Tumour embolism 15.05 12.67 7 147738 130 64350857
Clostridial infection 15.00 12.67 35 147710 5084 64345903
Bone marrow infiltration 14.99 12.67 11 147734 491 64350496
Diabetes mellitus inadequate control 14.99 12.67 16 147729 21305 64329682
Seizure 14.97 12.67 494 147251 166398 64184589
Enterocolitis infectious 14.96 12.67 23 147722 2441 64348546
Biliary dilatation 14.95 12.67 22 147723 2246 64348741
Lethargy 14.94 12.67 101 147644 72493 64278494
Heart rate decreased 14.93 12.67 70 147675 54997 64295990
Transaminases 14.90 12.67 6 147739 77 64350910
Cystic lung disease 14.84 12.67 9 147736 291 64350696
Thrombophlebitis 14.79 12.67 37 147708 5617 64345370
Nail pigmentation 14.78 12.67 9 147736 293 64350694
Radiation pneumonitis 14.77 12.67 27 147718 3301 64347686
Uterine adhesions 14.73 12.67 5 147740 38 64350949
Carpal tunnel syndrome 14.72 12.67 9 147736 15819 64335168
Cholangitis sclerosing 14.70 12.67 20 147725 1899 64349088
Cardiomyopathy 14.67 12.67 104 147641 25252 64325735
Subclavian vein thrombosis 14.61 12.67 22 147723 2292 64348695
IIIrd nerve paralysis 14.58 12.67 15 147730 1059 64349928
Pelvic fluid collection 14.56 12.67 12 147733 636 64350351
Heart rate increased 14.55 12.67 150 147595 98525 64252462
Tendonitis 14.51 12.67 15 147730 20267 64330720
Gastric varices 14.46 12.67 11 147734 519 64350468
Jugular vein thrombosis 14.44 12.67 29 147716 3802 64347185
Eye infection bacterial 14.42 12.67 8 147737 218 64350769
Enterobacter test positive 14.38 12.67 10 147735 410 64350577
Encephalitis 14.35 12.67 62 147683 12509 64338478
Necrotising colitis 14.31 12.67 14 147731 930 64350057
Tinnitus 14.27 12.67 36 147709 34097 64316890
Musculoskeletal disorder 14.27 12.67 12 147733 17894 64333093
Haemodialysis 14.17 12.67 11 147734 17066 64333921
Bursitis 14.15 12.67 17 147728 21468 64329519
Peripheral sensorimotor neuropathy 14.13 12.67 23 147722 2562 64348425
Increased appetite 14.10 12.67 3 147742 10143 64340844
Depressed level of consciousness 14.06 12.67 119 147626 81317 64269670
Metastases to skin 14.06 12.67 17 147728 1435 64349552
Pigmentation disorder 14.03 12.67 32 147713 4580 64346407
Post procedural fistula 13.97 12.67 8 147737 232 64350755
Appendicitis perforated 13.96 12.67 24 147721 2796 64348191
Bone marrow disorder 13.93 12.67 24 147721 2801 64348186
Skin cancer 13.92 12.67 5 147740 11969 64339018
Dialysis 13.91 12.67 11 147734 16909 64334078
Heart rate irregular 13.87 12.67 26 147719 27387 64323600
Mydriasis 13.84 12.67 9 147736 15303 64335684
Gastrointestinal stoma complication 13.83 12.67 21 147724 2205 64348782
Bladder cancer 13.79 12.67 4 147741 10970 64340017
Hypertransaminasaemia 13.79 12.67 42 147703 7149 64343838
Pachymeningitis 13.76 12.67 8 147737 239 64350748
Chromaturia 13.74 12.67 19 147726 22592 64328395
Bone density decreased 13.71 12.67 3 147742 9949 64341038
Macular cyst 13.71 12.67 5 147740 48 64350939
Colon cancer recurrent 13.71 12.67 6 147739 96 64350891
Diabetic retinal oedema 13.64 12.67 9 147736 338 64350649
Exudative retinopathy 13.55 12.67 4 147741 18 64350969
Haemoglobin decreased 13.53 12.67 561 147184 194502 64156485
Portal hypertensive gastropathy 13.49 12.67 15 147730 1157 64349830
Joint effusion 13.48 12.67 7 147738 13466 64337521
Iritis 13.48 12.67 25 147720 3091 64347896
Adrenal insufficiency 13.46 12.67 93 147652 22394 64328593
Tumour thrombosis 13.43 12.67 6 147739 101 64350886
Gastrointestinal disorder 13.41 12.67 284 147461 89425 64261562
Chest pain 13.38 12.67 425 147320 235555 64115432
Nodular regenerative hyperplasia 13.37 12.67 13 147732 857 64350130
Malaise 13.34 12.67 757 146988 395490 63955497
Pathogen resistance 13.34 12.67 6 147739 12537 64338450
Autoimmune haemolytic anaemia 13.26 12.67 41 147704 7035 64343952
Injection site haemorrhage 13.21 12.67 22 147723 24256 64326731
Perthes disease 13.17 12.67 3 147742 3 64350984
Gliomatosis cerebri 13.17 12.67 3 147742 3 64350984
Pelvic sepsis 13.17 12.67 3 147742 3 64350984
Sinus bradycardia 13.17 12.67 20 147725 22873 64328114
Intestinal strangulation 13.11 12.67 5 147740 55 64350932
KL-6 increased 13.11 12.67 5 147740 55 64350932
Enthesopathy 13.09 12.67 3 147742 9635 64341352
Hemiplegia 13.09 12.67 61 147684 12707 64338280
Upper limb fracture 13.08 12.67 9 147736 14857 64336130
Dementia 13.08 12.67 17 147728 20749 64330238
Haemorrhagic tumour necrosis 13.04 12.67 4 147741 21 64350966
Drug level decreased 13.04 12.67 5 147740 11498 64339489
Skin burning sensation 13.04 12.67 4 147741 10579 64340408
Sputum discoloured 13.00 12.67 13 147732 17843 64333144
Skin disorder 12.93 12.67 108 147637 27572 64323415
Urine protein/creatinine ratio increased 12.91 12.67 12 147733 748 64350239
Rib fracture 12.88 12.67 22 147723 24016 64326971
Haptoglobin decreased 12.88 12.67 15 147730 1217 64349770
Thrombocytopenic purpura 12.87 12.67 20 147725 2142 64348845
Intervertebral disc degeneration 12.86 12.67 7 147738 13113 64337874
Mean cell haemoglobin concentration decreased 12.84 12.67 27 147718 3657 64347330
Rectal tenesmus 12.82 12.67 14 147731 1059 64349928
Retinal cyst 12.77 12.67 6 147739 114 64350873
Full blood count decreased 12.73 12.67 20 147725 22562 64328425
Pneumonia chlamydial 12.68 12.67 6 147739 116 64350871
Choroiditis 12.67 12.67 14 147731 1073 64349914

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FG01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
VEGF/VEGFR (Vascular Endothelial Growth Factor) inhibitors
ATC S01LA08 SENSORY ORGANS
OPHTHALMOLOGICALS
OCULAR VASCULAR DISORDER AGENTS
Antineovascularisation agents
MeSH PA D020533 Angiogenesis Inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D006131 Growth Inhibitors
MeSH PA D006133 Growth Substances
FDA MoA N0000178291 Vascular Endothelial Growth Factor-directed Antibody Interactions
FDA MoA N0000193542 Vascular Endothelial Growth Factor Inhibitors
FDA EPC N0000193543 Vascular Endothelial Growth Factor Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Secondary malignant neoplasm of colon indication 94260004
Liver cell carcinoma indication 109841003 DOID:684
Malignant neoplasm of breast indication 254837009 DOID:1612
Malignant epithelial tumor of ovary indication 254849005
Carcinoma of cervix indication 285432005 DOID:2893
Malignant tumor of fallopian tube indication 363444001 DOID:1964
Malignant tumor of peritoneum indication 363492001
Glioblastoma multiforme indication 393563007
Nonsquamous nonsmall cell neoplasm of lung indication 440173001
Metastatic renal cell carcinoma indication 702392008
Malignant neoplasm of colon and/or rectum indication 781382000
Age-related macular degeneration off-label use 267718000 DOID:10871




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vascular endothelial growth factor A Secreted ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D06409 KEGG_DRUG
4021437 VUID
N0000148845 NUI
4021437 VANDF
4038596 VANDF
CHEMBL1201583 ChEMBL_ID
6771 IUPHAR_LIGAND_ID
8017 INN_ID
DB00112 DRUGBANK_ID
2S9ZZM9Q9V UNII
2046138 RXNORM
18086 MMSL
267594 MMSL
33386 MMSL
49612 MMSL
d05214 MMSL
409405006 SNOMEDCT_US
409406007 SNOMEDCT_US
D000068258 MESH_DESCRIPTOR_UI
C0796392 UMLSCUI
008586 NDDF
017340 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zirabev HUMAN PRESCRIPTION DRUG LABEL 1 0069-0315 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
Zirabev HUMAN PRESCRIPTION DRUG LABEL 1 0069-0342 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 30 sections
Avastin HUMAN PRESCRIPTION DRUG LABEL 1 50242-060 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 28 sections
Avastin HUMAN PRESCRIPTION DRUG LABEL 1 50242-061 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 28 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-206 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-207 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 30 sections
ALYMSYS HUMAN PRESCRIPTION DRUG LABEL 1 70121-1754 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 24 sections
ALYMSYS HUMAN PRESCRIPTION DRUG LABEL 1 70121-1755 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 24 sections