bevacizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4956 216974-75-3

Description:

MoleculeDescription

Synonyms:

  • bevacizumab-awwb
  • mvasi
  • bevacizumab
  • avastin
  • rhuMAb-VEGF
  • bevacituzumab
  • bevacizumab (genetical recombination)
  • bevacizumab biosimilar 3
  • bevacizumab biosimilar 4
An anti-VEGF humanized murine monoclonal antibody. It inhibits VEGF RECEPTORS and helps to prevent PATHOLOGIC ANGIOGENESIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
April 18, 2007 PMDA Chugai Pharmaceutical
Feb. 26, 2004 FDA GENENTECH
Dec. 1, 2005 EMA Roche Registration Limited

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 4234.32 13.58 2816 144208 153799 90327624
Death 3450.07 13.58 3957 143067 452594 90028829
Proteinuria 1955.73 13.58 888 146136 22403 90459020
Myelosuppression 1588.92 13.58 1023 146001 52568 90428855
Off label use 1478.92 13.58 4513 142511 1097739 89383684
Malignant neoplasm progression 1288.84 13.58 1195 145829 105675 90375748
Gastrointestinal perforation 1260.70 13.58 409 146615 3923 90477500
Endophthalmitis 1106.80 13.58 378 146646 4307 90477116
Hypertension 994.19 13.58 2249 144775 455283 90026140
Neutrophil count decreased 954.47 13.58 847 146177 70685 90410738
Neutropenia 943.30 13.58 1467 145557 223437 90257986
Anaemia 929.28 13.58 1876 145148 350926 90130497
Palmar-plantar erythrodysaesthesia syndrome 885.03 13.58 557 146467 27466 90453957
Neuropathy peripheral 827.06 13.58 1064 145960 135906 90345517
Intestinal perforation 770.97 13.58 399 146625 13482 90467941
Metastases to liver 720.67 13.58 495 146529 28312 90453111
Epistaxis 718.65 13.58 785 146239 84340 90397083
Ascites 692.46 13.58 593 146431 47147 90434276
Joint swelling 660.94 13.58 39 146985 503261 89978162
Thrombocytopenia 582.25 13.58 1138 145886 207587 90273836
Large intestine perforation 567.78 13.58 289 146735 9423 90472000
Bone marrow failure 545.87 13.58 438 146586 31783 90449640
Arthropathy 540.42 13.58 11 147013 366231 90115192
Platelet count decreased 539.74 13.58 869 146155 136100 90345323
Systemic lupus erythematosus 537.50 13.58 10 147014 361886 90119537
Mucosal inflammation 529.55 13.58 556 146468 57069 90424354
Metastases to lung 527.90 13.58 327 146697 15664 90465759
Rheumatoid arthritis 523.05 13.58 14 147010 362600 90118823
Synovitis 512.33 13.58 4 147020 329748 90151675
Febrile neutropenia 512.07 13.58 920 146104 157429 90323994
Posterior reversible encephalopathy syndrome 505.44 13.58 361 146663 21978 90459445
Maternal exposure during pregnancy 501.12 13.58 19 147005 360044 90121379
Contraindicated product administered 470.74 13.58 10 147014 320129 90161294
Ovarian cancer recurrent 462.11 13.58 150 146874 1440 90479983
Glossodynia 418.86 13.58 26 146998 321753 90159670
Suspected transmission of an infectious agent via product 403.21 13.58 100 146924 305 90481118
Metastases to bone 392.72 13.58 328 146696 25177 90456246
Pulmonary embolism 392.44 13.58 736 146288 130084 90351339
Swelling 377.96 13.58 106 146918 418952 90062471
Peripheral swelling 375.37 13.58 103 146921 413003 90068420
Metastases to central nervous system 368.41 13.58 271 146753 17271 90464152
Neurotoxicity 361.84 13.58 291 146733 21176 90460247
Peritonitis 359.80 13.58 280 146744 19425 90461998
Peripheral sensory neuropathy 356.62 13.58 209 146815 9041 90472382
No adverse event 354.52 13.58 492 146532 67490 90413933
Neoplasm progression 348.98 13.58 395 146629 44091 90437332
White blood cell count decreased 347.58 13.58 809 146215 166300 90315123
Helicobacter infection 346.38 13.58 4 147020 226846 90254577
Pericarditis 342.24 13.58 25 146999 270126 90211297
Intestinal obstruction 338.80 13.58 357 146667 36774 90444649
Visual acuity reduced 337.73 13.58 290 146734 23120 90458303
Exposure during pregnancy 333.57 13.58 12 147012 238398 90243025
Abdominal discomfort 324.25 13.58 186 146838 477142 90004281
Musculoskeletal stiffness 320.77 13.58 49 146975 296483 90184940
Wound 318.91 13.58 54 146970 302926 90178497
Thrombotic microangiopathy 310.02 13.58 234 146790 15509 90465914
Metastases to peritoneum 309.83 13.58 146 146878 4009 90477414
Hepatic enzyme increased 309.34 13.58 100 146924 360636 90120787
Sinusitis 308.87 13.58 87 146937 343001 90138422
Small intestinal obstruction 308.27 13.58 264 146760 20970 90460453
Polyneuropathy 300.39 13.58 250 146774 19091 90462332
Therapy partial responder 299.71 13.58 264 146760 21779 90459644
Therapeutic product effect decreased 297.64 13.58 47 146977 277524 90203899
Fibromyalgia 293.44 13.58 9 147015 206260 90275163
Irritable bowel syndrome 288.27 13.58 11 147013 207437 90273986
Duodenal ulcer perforation 284.55 13.58 19 147005 221269 90260154
Drug hypersensitivity 284.27 13.58 203 146821 463406 90018017
Pleural effusion 281.31 13.58 585 146439 111406 90370017
Drug intolerance 279.69 13.58 192 146832 447399 90034024
Drug ineffective 275.76 13.58 1235 145789 1383063 89098360
Weight increased 275.10 13.58 169 146855 417758 90063665
Lower respiratory tract infection 274.33 13.58 40 146984 250619 90230804
Condition aggravated 270.30 13.58 342 146682 595203 89886220
Leukopenia 269.43 13.58 540 146484 100170 90381253
Ileus 267.67 13.58 219 146805 16327 90465096
Folliculitis 267.36 13.58 16 147008 204337 90277086
Blister 267.10 13.58 46 146978 254952 90226471
Diarrhoea 261.90 13.58 2494 144530 936696 89544727
Retinal haemorrhage 261.90 13.58 145 146879 5619 90475804
Asthma 261.89 13.58 40 146984 242120 90239303
Metastases to meninges 259.45 13.58 125 146899 3610 90477813
Osteonecrosis of jaw 258.28 13.58 318 146706 38785 90442638
Arthralgia 257.50 13.58 550 146474 777972 89703451
Detachment of retinal pigment epithelium 255.59 13.58 73 146951 432 90480991
Age-related macular degeneration 254.14 13.58 79 146945 650 90480773
Pain 253.15 13.58 804 146220 995537 89485886
Blood cholesterol increased 253.01 13.58 23 147001 207989 90273434
Myelodysplastic syndrome 246.26 13.58 231 146793 20672 90460751
Type 2 diabetes mellitus 245.79 13.58 23 147001 203221 90278202
Injury 245.00 13.58 20 147004 197329 90284094
Wheezing 244.89 13.58 45 146979 238035 90243388
Small intestinal perforation 242.69 13.58 98 146926 1831 90479592
Treatment failure 242.15 13.58 95 146929 303833 90177590
Abdominal pain 239.76 13.58 1270 145754 394451 90086972
Dehydration 239.60 13.58 777 146247 193670 90287753
Urticaria 239.08 13.58 104 146920 312630 90168793
Nasopharyngitis 234.47 13.58 190 146834 406914 90074509
Macular oedema 229.95 13.58 126 146898 4783 90476640
Blindness 227.47 13.58 247 146777 26321 90455102
Mobility decreased 226.66 13.58 63 146961 250671 90230752
Pruritus 219.61 13.58 337 146687 541188 89940235
Psoriasis 215.54 13.58 5 147019 147749 90333674
Discomfort 214.85 13.58 88 146936 274247 90207176
Embolism 213.94 13.58 153 146871 9328 90472095
Completed suicide 211.25 13.58 5 147019 145053 90336370
Haematotoxicity 209.28 13.58 169 146855 12366 90469057
Nephrotic syndrome 204.77 13.58 135 146889 7204 90474219
Product dose omission issue 203.15 13.58 110 146914 291577 90189846
Drug interaction 201.85 13.58 98 146926 276355 90205068
Pneumothorax 196.04 13.58 196 146828 18971 90462452
Tumour necrosis 195.10 13.58 70 146954 931 90480492
Nausea 192.43 13.58 2689 144335 1107627 89373796
Wound dehiscence 191.99 13.58 119 146905 5703 90475720
Hydronephrosis 191.94 13.58 160 146864 12242 90469181
Deep vein thrombosis 190.82 13.58 444 146580 91176 90390247
Subretinal fluid 190.80 13.58 63 146961 641 90480782
Vitreous floaters 189.39 13.58 130 146894 7419 90474004
Joint range of motion decreased 185.69 13.58 8 147016 135635 90345788
Hepatic failure 181.38 13.58 270 146754 39458 90441965
Osteoarthritis 180.99 13.58 47 146977 195683 90285740
Retinal oedema 179.15 13.58 67 146957 1009 90480414
Injection site pain 178.23 13.58 33 146991 173666 90307757
Protein urine 178.13 13.58 62 146962 750 90480673
Sleep disorder 176.65 13.58 51 146973 197979 90283444
Eye haemorrhage 173.67 13.58 139 146885 10041 90471382
Pseudocirrhosis 172.71 13.58 63 146961 881 90480542
Photopsia 171.55 13.58 105 146919 4919 90476504
Metastasis 169.07 13.58 112 146912 6025 90475398
Vomiting 167.85 13.58 1984 145040 786309 89695114
Infusion related reaction 167.28 13.58 261 146763 416519 90064904
Rectal perforation 162.38 13.58 52 146972 476 90480947
Drug effective for unapproved indication 161.03 13.58 120 146904 7798 90473625
Tumour haemorrhage 160.51 13.58 75 146949 2019 90479404
Rash 157.87 13.58 710 146314 795390 89686033
Hypertensive crisis 156.91 13.58 168 146856 17616 90463807
Hepatic atrophy 156.46 13.58 44 146980 244 90481179
Bursitis 156.25 13.58 16 147008 131638 90349785
Insomnia 154.70 13.58 188 146836 333286 90148137
Cystoid macular oedema 154.15 13.58 73 146951 2027 90479396
Glomerular vascular disorder 153.83 13.58 33 146991 38 90481385
Decreased appetite 151.67 13.58 1088 145936 375452 90105971
Acute myeloid leukaemia 151.28 13.58 177 146847 20463 90460960
Nasal septum perforation 150.99 13.58 54 146970 711 90480712
Carbohydrate antigen 125 increased 150.69 13.58 83 146941 3183 90478240
Urogenital fistula 150.41 13.58 48 146976 434 90480989
Fistula 148.97 13.58 137 146887 11952 90469471
Lip dry 148.87 13.58 3 147021 100952 90380471
Protein urine present 146.87 13.58 108 146916 6876 90474547
Contusion 144.82 13.58 117 146907 251099 90230324
Hepatic function abnormal 143.12 13.58 264 146760 46024 90435399
Constipation 141.90 13.58 858 146166 279537 90201886
Interstitial lung disease 141.63 13.58 354 146670 76051 90405372
Metastases to lymph nodes 141.19 13.58 131 146893 11558 90469865
Depression 137.80 13.58 171 146853 300430 90180993
Facet joint syndrome 137.38 13.58 5 147019 98384 90383039
Female genital tract fistula 135.59 13.58 156 146868 17712 90463711
Loss of personal independence in daily activities 135.10 13.58 28 146996 136077 90345346
Eye discharge 135.03 13.58 110 146914 8148 90473275
Migraine 133.67 13.58 71 146953 190321 90291102
Subileus 131.74 13.58 79 146945 3565 90477858
Retinal pigment epithelial tear 127.46 13.58 37 146987 234 90481189
Injection site erythema 124.98 13.58 9 147015 98493 90382930
Obesity 124.74 13.58 13 147011 105494 90375929
Hospitalisation 123.80 13.58 28 146996 128072 90353351
Lower limb fracture 123.49 13.58 3 147021 85010 90396413
Portal hypertension 122.79 13.58 83 146941 4618 90476805
Ovarian cancer metastatic 121.74 13.58 51 146973 1050 90480373
Overdose 119.55 13.58 53 146971 157656 90323767
Vitritis 118.15 13.58 56 146968 1558 90479865
Bacterial endophthalmitis 118.11 13.58 33 146991 178 90481245
Arthritis 118.03 13.58 62 146962 167253 90314170
Uveitis 117.58 13.58 137 146887 15766 90465657
Memory impairment 114.74 13.58 91 146933 197153 90284270
Aortic dissection 113.10 13.58 62 146962 2355 90479068
Red blood cell sedimentation rate increased 112.61 13.58 5 147019 82590 90398833
Gastric perforation 112.20 13.58 58 146966 1953 90479470
Hypersensitivity 112.11 13.58 371 146653 454306 90027117
Sciatica 111.26 13.58 16 147008 101366 90380057
Sepsis 110.61 13.58 580 146444 179234 90302189
Grip strength decreased 110.50 13.58 11 147013 92565 90388858
Skin toxicity 110.21 13.58 90 146934 6689 90474734
Injection site reaction 109.75 13.58 11 147013 92069 90389354
Tumour marker increased 109.23 13.58 84 146940 5723 90475700
Road traffic accident 109.20 13.58 21 147003 107605 90373818
Dysphonia 108.33 13.58 284 146740 62800 90418623
C-reactive protein increased 107.64 13.58 82 146942 181307 90300116
Inflammation 106.92 13.58 80 146944 178512 90302911
Gait inability 106.71 13.58 52 146972 146404 90335019
Malignant pleural effusion 106.49 13.58 64 146960 2900 90478523
Fall 106.27 13.58 412 146612 481398 90000025
Tumour perforation 104.57 13.58 28 146996 125 90481298
Prescribed underdose 104.09 13.58 4 147020 75015 90406408
Carcinoembryonic antigen increased 103.71 13.58 58 146966 2292 90479131
Dizziness 103.61 13.58 548 146476 588736 89892687
Intentional product misuse 103.49 13.58 12 147012 89592 90391831
Hepatitis B reactivation 103.40 13.58 70 146954 3904 90477519
Asthenia 99.77 13.58 1312 145712 532439 89948984
Ejection fraction decreased 99.75 13.58 164 146860 26089 90455334
Hip arthroplasty 99.52 13.58 6 147018 76202 90405221
Gastrointestinal toxicity 99.01 13.58 98 146926 9369 90472054
Muscle spasms 98.81 13.58 160 146864 251723 90229700
Liver injury 98.81 13.58 79 146945 170488 90310935
Hypomagnesaemia 97.72 13.58 193 146831 35395 90446028
Vitreous detachment 97.68 13.58 56 146968 2322 90479101
Osteoporosis 97.59 13.58 19 147005 96512 90384911
Cardiomyopathy 97.53 13.58 141 146883 20065 90461358
Osteonecrosis 97.12 13.58 162 146862 26079 90455344
Duodenal perforation 95.69 13.58 43 146981 1055 90480368
Hypercholesterolaemia 95.61 13.58 23 147001 100869 90380554
Cerebral ischaemia 95.44 13.58 85 146939 7111 90474312
Enterocutaneous fistula 95.38 13.58 48 146976 1526 90479897
Gait disturbance 95.30 13.58 173 146851 260323 90221100
Vitreous haemorrhage 95.11 13.58 57 146967 2569 90478854
Dry mouth 94.94 13.58 95 146929 183964 90297459
Disseminated intravascular coagulation 94.91 13.58 144 146880 21394 90460029
Cataract nuclear 92.67 13.58 42 146982 1052 90480371
Night sweats 91.87 13.58 47 146977 128719 90352704
Oesophagitis 91.61 13.58 126 146898 17123 90464300
Influenza 90.52 13.58 57 146967 139207 90342216
Breast cancer metastatic 90.28 13.58 117 146907 15015 90466408
Suicidal ideation 90.20 13.58 8 147016 73847 90407576
Hypokalaemia 89.81 13.58 436 146588 130680 90350743
Pain in extremity 88.34 13.58 403 146621 450126 90031297
Pulmonary fibrosis 88.21 13.58 32 146992 107471 90373952
Peripheral venous disease 88.11 13.58 15 147009 83906 90397517
Metamorphopsia 87.03 13.58 44 146980 1413 90480010
Autoimmune disorder 86.85 13.58 11 147013 76733 90404690
Ear infection 86.75 13.58 7 147017 69768 90411655
Dermatitis acneiform 86.16 13.58 76 146948 6278 90475145
Cholangitis 85.80 13.58 80 146944 7102 90474321
Anastomotic leak 85.30 13.58 34 146990 613 90480810
Adverse event 85.06 13.58 42 146982 117376 90364047
Suicide attempt 84.86 13.58 11 147013 75388 90406035
Immune-mediated hepatitis 84.19 13.58 55 146969 2889 90478534
Delirium 84.05 13.58 32 146992 104327 90377096
Product use issue 83.48 13.58 266 146758 329653 90151770
Foot deformity 83.38 13.58 3 147021 59648 90421775
COVID-19 82.75 13.58 91 146933 168752 90312671
Confusional state 82.72 13.58 334 146690 385871 90095552
Malignant ascites 81.33 13.58 37 146987 935 90480488
Colorectal cancer metastatic 79.61 13.58 35 146989 814 90480609
Adverse drug reaction 78.31 13.58 46 146978 116655 90364768
Haemoptysis 77.74 13.58 169 146855 33151 90448272
Left ventricular dysfunction 76.17 13.58 106 146918 14563 90466860
Metastases to pleura 75.68 13.58 45 146979 1999 90479424
Feeling abnormal 75.67 13.58 96 146928 167139 90314284
Joint stiffness 75.51 13.58 17 147007 78025 90403398
Immune thrombocytopenia 74.80 13.58 100 146924 13226 90468197
Headache 74.59 13.58 970 146054 861776 89619647
Abdominal abscess 74.18 13.58 65 146959 5322 90476101
Gastrooesophageal reflux disease 73.70 13.58 97 146927 166240 90315183
Pneumonitis 71.93 13.58 195 146829 43975 90437448
General physical health deterioration 71.80 13.58 886 146138 354229 90127194
Therapeutic product effect incomplete 71.58 13.58 128 146896 193768 90287655
Bronchitis 71.07 13.58 86 146938 152841 90328582
Renal-limited thrombotic microangiopathy 70.92 13.58 23 147001 220 90481203
Immune-mediated endocrinopathy 70.80 13.58 20 147004 113 90481310
Lymphangiosis carcinomatosa 70.36 13.58 40 146984 1632 90479791
Lymphocyte count decreased 69.83 13.58 167 146857 34883 90446540
Neoplasm 69.70 13.58 79 146945 8824 90472599
Leukoencephalopathy 69.52 13.58 60 146964 4813 90476610
Pneumonia 68.98 13.58 682 146342 637377 89844046
Enteritis 68.24 13.58 84 146940 10237 90471186
Cardiac failure 67.85 13.58 354 146670 109142 90372281
Blepharospasm 67.73 13.58 6 147018 55439 90425984
Amnesia 67.02 13.58 47 146977 108458 90372965
Exostosis 66.98 13.58 5 147019 53129 90428294
Peripheral motor neuropathy 66.76 13.58 41 146983 1932 90479491
Upper respiratory tract infection 66.42 13.58 66 146958 128252 90353171
Perforation 66.36 13.58 41 146983 1953 90479470
Hypothyroidism 65.96 13.58 213 146811 52914 90428509
Haemorrhage 65.38 13.58 254 146770 69115 90412308
Pregnancy 65.33 13.58 11 147013 62036 90419387
Lymphocele 65.12 13.58 30 146994 781 90480642
Eastern Cooperative Oncology Group performance status worsened 64.87 13.58 40 146984 1899 90479524
Dry throat 64.65 13.58 72 146952 7888 90473535
Retinal thickening 64.23 13.58 25 146999 422 90481001
Inappropriate schedule of product administration 63.83 13.58 90 146934 149843 90331580
Eye inflammation 63.74 13.58 71 146953 7780 90473643
Alopecia 63.67 13.58 506 146518 494565 89986858
Ovarian cancer 63.38 13.58 66 146958 6701 90474722
Retinal exudates 63.03 13.58 28 146996 668 90480755
Retinal detachment 62.93 13.58 66 146958 6756 90474667
Injection site pruritus 62.69 13.58 7 147017 53827 90427596
Pelvic abscess 62.68 13.58 40 146984 2018 90479405
Hypophosphataemia 62.20 13.58 97 146927 14757 90466666
Injection site swelling 62.15 13.58 11 147013 59828 90421595
Retinal degeneration 61.91 13.58 32 146992 1077 90480346
Neutrophil count abnormal 61.28 13.58 52 146972 4076 90477347
Varices oesophageal 61.07 13.58 50 146974 3729 90477694
Stress 60.66 13.58 28 146996 81367 90400056
Throat tightness 60.38 13.58 142 146882 29342 90452081
Portal vein thrombosis 60.35 13.58 46 146978 3092 90478331
Pyrexia 60.32 13.58 1449 145575 659036 89822387
Immune-mediated adverse reaction 60.30 13.58 29 146995 834 90480589
Aortoenteric fistula 60.25 13.58 12 147012 6 90481417
Colitis 60.23 13.58 249 146775 69693 90411730
Ileal perforation 60.20 13.58 25 146999 503 90480920
Transmission of an infectious agent via product 60.19 13.58 18 147006 128 90481295
Fluid retention 60.13 13.58 34 146990 88057 90393366
Cervix carcinoma recurrent 59.32 13.58 19 147005 174 90481249
Metastases to skin 58.81 13.58 39 146985 2101 90479322
Nail toxicity 58.73 13.58 23 147001 395 90481028
Haemoglobin 58.66 13.58 19 147005 181 90481242
Superior vena cava syndrome 58.50 13.58 27 146997 706 90480717
Anxiety 58.35 13.58 281 146743 309491 90171932
Tumour ulceration 58.29 13.58 20 147004 231 90481192
Laryngospasm 57.90 13.58 46 146978 3287 90478136
Lupus-like syndrome 57.78 13.58 6 147018 48840 90432583
Retinal disorder 57.70 13.58 37 146987 1882 90479541
Haematuria 57.65 13.58 155 146869 34782 90446641
Radiation necrosis 57.52 13.58 26 146998 647 90480776
Medication error 57.31 13.58 33 146991 84619 90396804
Macular ischaemia 56.37 13.58 14 147010 43 90481380
Venous thrombosis limb 56.36 13.58 46 146978 3416 90478007
Granulocyte count decreased 56.31 13.58 40 146984 2412 90479011
Metastatic neoplasm 56.30 13.58 53 146971 4762 90476661
Lung disorder 56.17 13.58 98 146926 149785 90331638
Mucosal toxicity 56.06 13.58 22 147002 380 90481043
Gastrointestinal fistula 55.95 13.58 24 147000 525 90480898
Dyspepsia 55.72 13.58 152 146872 198008 90283415
Intraocular pressure increased 55.63 13.58 63 146961 7030 90474393
Illness 55.43 13.58 32 146992 81937 90399486
Device related infection 54.79 13.58 126 146898 25660 90455763
Blood bilirubin increased 54.61 13.58 175 146849 43295 90438128
Incorrect dose administered 54.54 13.58 30 146994 78900 90402523
Thrombosis 54.08 13.58 249 146775 73002 90408421
Haemoglobin decreased 53.93 13.58 448 146576 161508 90319915
Product use in unapproved indication 53.91 13.58 322 146702 335914 90145509
Toxicity to various agents 53.70 13.58 262 146762 287584 90193839
Stoma site haemorrhage 53.60 13.58 31 146993 1307 90480116
Metastases to ovary 53.58 13.58 23 147001 504 90480919
Anal fistula 53.49 13.58 49 146975 4252 90477171
Large intestinal obstruction 52.67 13.58 40 146984 2674 90478749
Sudden death 52.47 13.58 76 146948 10833 90470590
Second primary malignancy 52.41 13.58 74 146950 10304 90471119
Peritoneal disorder 52.23 13.58 24 147000 621 90480802
Colon cancer metastatic 51.87 13.58 31 146993 1390 90480033
Cerebral haemorrhage 51.86 13.58 148 146876 34374 90447049
Venous thrombosis 51.85 13.58 54 146970 5483 90475940
Underdose 51.79 13.58 12 147012 54005 90427418
Laryngeal necrosis 51.59 13.58 11 147013 12 90481411
Haemolytic anaemia 51.24 13.58 78 146946 11619 90469804
Somnolence 51.17 13.58 171 146853 208913 90272510
Immune-mediated enterocolitis 51.15 13.58 50 146974 4707 90476716
Pulmonary haemorrhage 51.02 13.58 64 146960 7949 90473474
Macular hole 50.93 13.58 27 146997 958 90480465
Pneumoperitoneum 50.74 13.58 33 146991 1720 90479703
Enterocolitis 50.33 13.58 73 146951 10417 90471006
Ciliary hyperaemia 50.21 13.58 10 147014 5 90481418
Abortion spontaneous 49.90 13.58 13 147011 54043 90427380
Fistula of small intestine 49.83 13.58 21 147003 439 90480984
Retinal vascular disorder 49.72 13.58 18 147006 246 90481177
Hypoalbuminaemia 49.55 13.58 91 146933 15806 90465617
Paronychia 49.48 13.58 63 146961 7943 90473480
Electrocardiogram QT prolonged 49.40 13.58 28 146996 72428 90408995
Vitreous opacities 49.39 13.58 21 147003 449 90480974
Infection 49.38 13.58 364 146660 361730 90119693
Immune-mediated lung disease 48.64 13.58 33 146991 1847 90479576
Visual impairment 48.34 13.58 374 146650 131991 90349432
Frequent bowel movements 48.33 13.58 16 147008 56919 90424504
Disability 48.20 13.58 5 147019 40740 90440683
Cerebral infarction 47.98 13.58 122 146902 26474 90454949
Performance status decreased 47.93 13.58 46 146978 4234 90477189
Sedation 47.60 13.58 10 147014 48161 90433262
Renal impairment 47.27 13.58 313 146711 105108 90376315
Metastases to spine 47.25 13.58 43 146981 3700 90477723
Suspected counterfeit product 47.12 13.58 21 147003 505 90480918
Wrong technique in product usage process 46.90 13.58 29 146995 71542 90409881
Treatment noncompliance 46.69 13.58 13 147011 51714 90429709
Tumour rupture 46.59 13.58 17 147007 238 90481185
Eczema 46.41 13.58 14 147010 52856 90428567
Glioblastoma 46.38 13.58 25 146999 918 90480505
Drug reaction with eosinophilia and systemic symptoms 46.32 13.58 7 147017 42751 90438672
Retinal neovascularisation 45.65 13.58 13 147011 76 90481347
Hemiparesis 45.47 13.58 134 146890 31685 90449738
Oesophageal varices haemorrhage 45.44 13.58 29 146995 1463 90479960
Retinal artery occlusion 45.25 13.58 34 146990 2237 90479186
Incorrect route of product administration 45.18 13.58 13 147011 50613 90430810
Duodenal ulcer 45.14 13.58 66 146958 9486 90471937
Pancytopenia 45.14 13.58 342 146682 119921 90361502
Eye pruritus 45.12 13.58 126 146898 28901 90452522
Disease recurrence 44.97 13.58 149 146875 37504 90443919
Acute abdomen 44.96 13.58 30 146994 1633 90479790
Adenocarcinoma 44.88 13.58 39 146985 3157 90478266
Retinitis 44.78 13.58 5 147019 38453 90442970
Pantoea agglomerans infection 44.56 13.58 12 147012 55 90481368
Embolism venous 44.55 13.58 41 146983 3579 90477844
Therapy interrupted 44.48 13.58 13 147011 50095 90431328
Adenocarcinoma metastatic 44.44 13.58 16 147008 215 90481208
Biliary fistula 43.99 13.58 10 147014 18 90481405
Microangiopathic haemolytic anaemia 43.91 13.58 23 147001 796 90480627
Enterocolitis infectious 43.82 13.58 32 146992 2015 90479408
Onycholysis 43.57 13.58 33 146991 2197 90479226
Cardiotoxicity 43.07 13.58 71 146953 11318 90470105
Oedema 42.97 13.58 173 146851 200122 90281301
Macular fibrosis 42.33 13.58 18 147006 385 90481038
Dysaesthesia pharynx 42.26 13.58 15 147009 193 90481230
Macular scar 42.14 13.58 13 147011 104 90481319
Retinal scar 42.00 13.58 14 147010 147 90481276
Nasal congestion 41.92 13.58 44 146980 83370 90398053
Enterovesical fistula 41.77 13.58 21 147003 666 90480757
Abdominal infection 41.55 13.58 33 146991 2357 90479066
Serous cystadenocarcinoma ovary 41.49 13.58 10 147014 26 90481397
Wound infection 41.31 13.58 68 146956 106334 90375089
Malignant glioma 41.22 13.58 9 147015 12 90481411
Urinary tract obstruction 41.14 13.58 32 146992 2217 90479206
Neovascular age-related macular degeneration 41.09 13.58 18 147006 415 90481008
Cystitis radiation 40.92 13.58 12 147012 79 90481344
Haemolytic uraemic syndrome 40.89 13.58 35 146989 2776 90478647
Metastases to bone marrow 40.84 13.58 20 147004 599 90480824
Red cell distribution width increased 40.75 13.58 72 146952 12135 90469288
Ill-defined disorder 40.73 13.58 158 146866 184733 90296690
Autoimmune haemolytic anaemia 40.68 13.58 48 146976 5597 90475826
Thyroiditis 40.56 13.58 39 146985 3598 90477825
Drug resistance 40.47 13.58 125 146899 30324 90451099
Neutropenic infection 40.37 13.58 29 146995 1780 90479643
Metastases to abdominal wall 40.25 13.58 14 147010 169 90481254
Optical coherence tomography abnormal 40.22 13.58 15 147009 224 90481199
Neutropenic sepsis 40.08 13.58 90 146934 18040 90463383
Sleep apnoea syndrome 39.98 13.58 3 147021 31744 90449679
Retinal depigmentation 39.91 13.58 16 147008 293 90481130
Tracheal fistula 39.74 13.58 11 147013 57 90481366
Retinal vein occlusion 39.60 13.58 33 146991 2523 90478900
Hyponatraemia 39.55 13.58 360 146664 133178 90348245
Mechanical ileus 39.54 13.58 21 147003 748 90480675
Chronic obstructive pulmonary disease 39.33 13.58 37 146987 73792 90407631
Acquired gene mutation 39.30 13.58 25 146999 1254 90480169
Plasma cell myeloma 39.28 13.58 9 147015 40819 90440604
Lymphadenopathy mediastinal 39.23 13.58 36 146988 3131 90478292
Injection site bruising 38.96 13.58 18 147006 52289 90429134
Choroidal neovascularisation 38.88 13.58 17 147007 390 90481033
Gingival bleeding 38.73 13.58 79 146945 14824 90466599
Gastrointestinal necrosis 38.67 13.58 36 146988 3189 90478234
Gastrointestinal anastomotic leak 38.50 13.58 15 147009 254 90481169
Bladder tamponade 38.46 13.58 13 147011 143 90481280
Venous pressure jugular decreased 38.43 13.58 10 147014 39 90481384
Vaginal fistula 38.34 13.58 19 147005 584 90480839
Irritability 38.27 13.58 6 147018 35656 90445767
Pharyngeal oedema 38.18 13.58 75 146949 13696 90467727
Seizure 38.11 13.58 397 146627 152232 90329191
Choroiditis 37.71 13.58 15 147009 269 90481154
Acute coronary syndrome 37.69 13.58 65 146959 10748 90470675
Colitis ischaemic 37.63 13.58 70 146954 12276 90469147
Blood creatinine increased 37.31 13.58 287 146737 101099 90380324
Immunodeficiency 36.96 13.58 12 147012 43222 90438201
Retinal ischaemia 36.89 13.58 17 147007 443 90480980
Erythema multiforme 36.79 13.58 69 146955 12177 90469246
Pulmonary sarcoidosis 36.49 13.58 24 147000 1275 90480148
Proctalgia 36.38 13.58 55 146969 8143 90473280
Pulpitis dental 36.26 13.58 22 147002 1014 90480409
Joint injury 36.19 13.58 5 147019 32659 90448764
Metastases to pelvis 36.18 13.58 18 147006 558 90480865
Hydrocephalus 36.17 13.58 47 146977 6047 90475376
Azotaemia 36.12 13.58 44 146980 5304 90476119
Pseudoendophthalmitis 36.09 13.58 8 147016 12 90481411
Cholecystitis acute 36.06 13.58 59 146965 9345 90472078
Walking aid user 35.86 13.58 7 147017 35499 90445924
Jaundice 35.61 13.58 125 146899 32392 90449031
Gastrointestinal disorder 35.47 13.58 257 146767 256430 90224993
Vitreous disorder 35.34 13.58 12 147012 134 90481289
Abdominal pain upper 35.27 13.58 357 146667 332317 90149106
Dyskinesia 35.26 13.58 8 147016 36526 90444897
Anastomotic fistula 35.24 13.58 9 147015 32 90481391
Lactic acidosis 35.13 13.58 19 147005 50444 90430979
Skin disorder 35.07 13.58 135 146889 36571 90444852
Periodontitis 35.05 13.58 37 146987 3816 90477607
Product prescribing error 34.90 13.58 4 147020 30141 90451282
Neutrophil count 34.89 13.58 16 147008 412 90481011
Arteriospasm coronary 34.84 13.58 42 146982 5008 90476415
Gallbladder rupture 34.84 13.58 17 147007 505 90480918
Iridocyclitis 34.81 13.58 36 146988 3625 90477798
Anterior chamber cell 34.77 13.58 19 147005 717 90480706
Palpitations 34.71 13.58 110 146914 136618 90344805
Atypical haemolytic uraemic syndrome 34.57 13.58 21 147003 970 90480453
Onychomycosis 34.47 13.58 9 147015 37367 90444056
Swelling face 34.45 13.58 49 146975 81303 90400120
Thrombophlebitis migrans 34.35 13.58 14 147010 268 90481155
Hypertensive encephalopathy 34.32 13.58 19 147005 736 90480687
Hyperammonaemia 33.93 13.58 47 146977 6428 90474995
Intestinal metastasis 33.92 13.58 13 147011 210 90481213
Respiratory disorder 33.92 13.58 33 146991 64783 90416640
Drug dependence 33.68 13.58 4 147020 29323 90452100
Hypopyon 33.52 13.58 20 147004 894 90480529
Cystitis haemorrhagic 33.47 13.58 43 146981 5470 90475953
Ischaemic stroke 33.26 13.58 95 146929 22071 90459352
Necrosis 33.18 13.58 47 146977 6563 90474860
Necrotising fasciitis 33.08 13.58 36 146988 3844 90477579
Therapy cessation 33.08 13.58 9 147015 36352 90445071
Incisional hernia 33.07 13.58 26 146998 1830 90479593
Blindness unilateral 33.06 13.58 51 146973 7685 90473738
Cutis laxa 32.88 13.58 12 147012 168 90481255
Drug withdrawal syndrome 32.78 13.58 4 147020 28719 90452704
Bone pain 32.77 13.58 192 146832 61791 90419632
Cervix cancer metastatic 32.75 13.58 10 147014 77 90481346
Neoplasm recurrence 32.72 13.58 33 146991 3226 90478197
Perirectal abscess 32.56 13.58 20 147004 943 90480480
Glomerulonephritis 32.41 13.58 29 146995 2441 90478982
Malaise 32.16 13.58 715 146309 585271 89896152
Haemoglobin abnormal 32.03 13.58 48 146976 7052 90474371
Musculoskeletal pain 31.84 13.58 156 146868 171095 90310328
Hallucination 31.80 13.58 36 146988 65923 90415500
Device issue 31.62 13.58 5 147019 29532 90451891
Extravasation 31.58 13.58 31 146993 2933 90478490
Blood pressure increased 31.55 13.58 472 146552 196745 90284678
Multiple sclerosis 31.47 13.58 4 147020 27836 90453587
Arterioenteric fistula 31.42 13.58 8 147016 28 90481395
Pelvic infection 31.06 13.58 14 147010 346 90481077
Neoplasm malignant 31.06 13.58 123 146901 33757 90447666
BRCA2 gene mutation 30.80 13.58 10 147014 96 90481327
Febrile bone marrow aplasia 30.67 13.58 56 146968 9682 90471741
Rectal cancer recurrent 30.58 13.58 8 147016 32 90481391
Bronchial fistula 30.58 13.58 8 147016 32 90481391
Rash pruritic 30.57 13.58 54 146970 82160 90399263
Lacrimation increased 30.48 13.58 105 146919 26957 90454466
Impaired healing 30.22 13.58 239 146785 233960 90247463
Cerebrovascular accident 30.21 13.58 320 146704 123213 90358210
Device dislocation 30.17 13.58 7 147017 31475 90449948
Angiogram retina abnormal 30.13 13.58 6 147018 3 90481420
Infected lymphocele 29.87 13.58 12 147012 221 90481202
Tumour invasion 29.86 13.58 13 147011 295 90481128
Accidental overdose 29.79 13.58 5 147019 28268 90453155
Malignant transformation 29.72 13.58 16 147008 586 90480837
Aspartate aminotransferase increased 29.71 13.58 276 146748 102661 90378762
Transformation to acute myeloid leukaemia 29.68 13.58 14 147010 385 90481038
Failure to anastomose 29.68 13.58 7 147017 16 90481407
Magnetic resonance imaging head abnormal 29.63 13.58 28 146996 2528 90478895
Splenomegaly 29.52 13.58 65 146959 12859 90468564
Hyperbilirubinaemia 29.50 13.58 68 146956 13868 90467555
Neck pain 29.40 13.58 91 146933 113872 90367551
Bladder perforation 29.27 13.58 11 147013 168 90481255
Ophthalmological examination abnormal 29.11 13.58 10 147014 116 90481307
Fulminant type 1 diabetes mellitus 29.09 13.58 18 147006 860 90480563
Anterior chamber inflammation 29 13.58 14 147010 406 90481017
Metastases to kidney 28.92 13.58 12 147012 241 90481182
Intracranial tumour haemorrhage 28.92 13.58 12 147012 241 90481182
Colonic fistula 28.85 13.58 13 147011 321 90481102
Renal failure 28.67 13.58 332 146692 130675 90350748
Systemic infection 28.61 13.58 37 146987 4738 90476685
Bradycardia 28.61 13.58 58 146966 83789 90397634
Ureteric fistula 28.56 13.58 7 147017 20 90481403
Hypocalcaemia 28.35 13.58 140 146884 42228 90439195
Oligoastrocytoma 28.31 13.58 7 147017 21 90481402
Vaginal perforation 28.31 13.58 7 147017 21 90481402
Gastropleural fistula 28.20 13.58 8 147016 46 90481377
Eye pain 28.18 13.58 144 146880 44024 90437399
Thrombotic thrombocytopenic purpura 27.87 13.58 34 146990 4104 90477319
Liver function test increased 27.85 13.58 60 146964 84795 90396628
Eye irritation 27.72 13.58 119 146905 33859 90447564
Laryngitis 27.55 13.58 25 146999 50728 90430695
Product contamination microbial 27.50 13.58 12 147012 274 90481149
Basal cell carcinoma 27.28 13.58 10 147014 33379 90448044
Gastric disorder 27.27 13.58 10 147014 33374 90448049
Abdominal hernia 27.15 13.58 40 146984 5788 90475635
Hypoaesthesia 27.12 13.58 353 146671 313857 90167566
Cholangitis sclerosing 27.03 13.58 25 146999 2196 90479227
Onychomadesis 27.01 13.58 21 147003 45977 90435446
Stress cardiomyopathy 26.99 13.58 64 146960 13291 90468132
Tumour fistulisation 26.96 13.58 7 147017 27 90481396
Nephrolithiasis 26.86 13.58 24 147000 49061 90432362
Blood alkaline phosphatase increased 26.77 13.58 151 146873 47928 90433495
Urine protein/creatinine ratio increased 26.75 13.58 18 147006 994 90480429
Myocarditis 26.66 13.58 65 146959 13741 90467682
Respiratory tract infection 26.62 13.58 34 146990 59044 90422379
Encephalitis 26.57 13.58 57 146967 11077 90470346
Tooth erosion 26.51 13.58 14 147010 493 90480930
Optic neuropathy 26.51 13.58 27 146997 2671 90478752
Retinal aneurysm 26.50 13.58 11 147013 221 90481202
Melanoderma 26.46 13.58 11 147013 222 90481201
Throat irritation 26.41 13.58 24 147000 48671 90432752
Pericardial effusion 26.30 13.58 124 146900 36709 90444714
Aphasia 26.22 13.58 138 146886 42674 90438749
Pelvic fluid collection 26.01 13.58 18 147006 1041 90480382
Iritis 26.00 13.58 31 146993 3655 90477768
Fixed bowel loop 25.98 13.58 6 147018 12 90481411
Polychromasia 25.88 13.58 11 147013 235 90481188
Carpal tunnel syndrome 25.73 13.58 4 147020 23924 90457499
Secondary cerebellar degeneration 25.72 13.58 8 147016 66 90481357
Drug tolerance decreased 25.62 13.58 10 147014 32120 90449303
Product counterfeit 25.57 13.58 10 147014 171 90481252
Dry age-related macular degeneration 25.46 13.58 11 147013 245 90481178
Tremor 25.42 13.58 145 146879 153028 90328395
Intestinal ischaemia 25.38 13.58 49 146975 8834 90472589
Anti-glomerular basement membrane disease 25.30 13.58 8 147016 70 90481353
Product quality issue 25.29 13.58 57 146967 79268 90402155
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 25.10 13.58 8 147016 72 90481351
Central nervous system haemorrhage 25.09 13.58 11 147013 254 90481169
Hepatic lesion 25.09 13.58 38 146986 5635 90475788
Agitation 25.01 13.58 44 146980 67054 90414369
Lip swelling 24.81 13.58 16 147008 38594 90442829
Thrombocytopenic purpura 24.71 13.58 22 147002 1839 90479584
Oesophageal fistula 24.66 13.58 10 147014 189 90481234
Ureteric stenosis 24.61 13.58 15 147009 697 90480726
Inferior vena cava stenosis 24.52 13.58 6 147018 17 90481406
Bleeding varicose vein 24.51 13.58 12 147012 359 90481064
Psychotic disorder 24.44 13.58 10 147014 31220 90450203
Device related thrombosis 24.40 13.58 23 147001 2070 90479353
Skin haemorrhage 24.35 13.58 3 147021 21377 90460046
Non-cirrhotic portal hypertension 24.24 13.58 12 147012 368 90481055
Therapeutic response shortened 24.21 13.58 4 147020 22875 90458548
Ear pain 24.19 13.58 35 146989 57667 90423756
Capillary leak syndrome 24.16 13.58 26 146998 2741 90478682
Hyperpyrexia 24.12 13.58 34 146990 4727 90476696
Vena cava thrombosis 24.10 13.58 25 146999 2527 90478896
Metastases to abdominal cavity 24.08 13.58 14 147010 596 90480827
Gene mutation 24.05 13.58 23 147001 2107 90479316
Metastases to heart 24.00 13.58 10 147014 203 90481220
Post procedural fistula 23.95 13.58 12 147012 378 90481045
Malignant hypertension 23.89 13.58 18 147006 1189 90480234
Intentional product use issue 23.87 13.58 489 146535 216403 90265020
Intestinal fistula 23.86 13.58 17 147007 1030 90480393
Metastases to soft tissue 23.68 13.58 11 147013 292 90481131
Anaemia of malignant disease 23.58 13.58 14 147010 620 90480803
Visual field defect 23.58 13.58 42 146982 7124 90474299
Hepatic pain 23.35 13.58 29 146995 3566 90477857
Gastroenteritis viral 23.31 13.58 10 147014 30345 90451078
Burning sensation 23.30 13.58 42 146982 63410 90418013
Ulcer haemorrhage 23.05 13.58 7 147017 26314 90455109
Dysaesthesia 22.96 13.58 35 146989 5220 90476203
Focal segmental glomerulosclerosis 22.85 13.58 21 147003 1830 90479593
Biliary dilatation 22.84 13.58 25 146999 2686 90478737
Normal newborn 22.78 13.58 5 147019 23357 90458066
Hepatic encephalopathy 22.62 13.58 61 146963 13711 90467712
Splenic artery thrombosis 22.58 13.58 7 147017 57 90481366
Rhabdomyolysis 22.58 13.58 30 146994 51226 90430197
Retinal vascular occlusion 22.55 13.58 12 147012 429 90480994
Rectal ulcer 22.50 13.58 19 147005 1479 90479944
Tumour pain 22.50 13.58 21 147003 1866 90479557
Impaired quality of life 22.47 13.58 5 147019 23139 90458284
Skin hyperpigmentation 22.34 13.58 40 146984 6811 90474612
Duodenal ulcer haemorrhage 22.29 13.58 24 147000 2532 90478891
Intestinal strangulation 22.25 13.58 8 147016 107 90481316
Anaphylactic shock 22.25 13.58 106 146918 31511 90449912
Urinary fistula 22.19 13.58 6 147018 28 90481395
Band sensation 22.13 13.58 17 147007 1156 90480267
Tachyphylaxis 22.08 13.58 11 147013 342 90481081
Hypermutation 21.96 13.58 7 147017 63 90481360
Optic ischaemic neuropathy 21.87 13.58 20 147004 1732 90479691
Cholecystitis 21.77 13.58 69 146955 16971 90464452
Breast cancer recurrent 21.75 13.58 35 146989 5468 90475955
Dysgeusia 21.73 13.58 153 146871 52407 90429016
Arterial thrombosis 21.42 13.58 19 147005 1581 90479842
Mycotic endophthalmitis 21.32 13.58 9 147015 189 90481234
Mean cell volume increased 21.32 13.58 33 146991 4988 90476435
Incorrect product administration duration 21.31 13.58 3 147021 19319 90462104
Pelvic pain 21.30 13.58 64 146960 15293 90466130
Conjunctival hyperaemia 21.29 13.58 26 146998 3143 90478280
Exposed bone in jaw 21.28 13.58 25 146999 2901 90478522
Retroperitoneal lymphadenopathy 21.25 13.58 14 147010 746 90480677
Metabolic acidosis 21.22 13.58 36 146988 55640 90425783
Mediastinal disorder 21.21 13.58 12 147012 485 90480938
Toxic anterior segment syndrome 21.17 13.58 22 147002 2228 90479195
Pneumatosis intestinalis 21.17 13.58 27 146997 3410 90478013
Adrenocorticotropic hormone deficiency 21.12 13.58 14 147010 754 90480669
Duodenal stenosis 21.08 13.58 13 147011 617 90480806
Myoclonus 21.08 13.58 3 147021 19165 90462258
Peritoneal neoplasm 21.05 13.58 7 147017 73 90481350
Ileus paralytic 21.00 13.58 33 146991 5052 90476371
Intestinal prolapse 20.95 13.58 8 147016 128 90481295
Pulmonary artery thrombosis 20.93 13.58 14 147010 765 90480658
Metastases to breast 20.81 13.58 11 147013 388 90481035
Perforation bile duct 20.74 13.58 5 147019 13 90481410
Lymphoedema 20.69 13.58 59 146965 13694 90467729
Non-infectious endophthalmitis 20.53 13.58 10 147014 296 90481127
Vaginal cuff dehiscence 20.48 13.58 5 147019 14 90481409
Transaminases 20.47 13.58 7 147017 80 90481343
Crying 20.42 13.58 8 147016 25637 90455786
Metastases to chest wall 20.33 13.58 13 147011 658 90480765
Seasonal allergy 20.33 13.58 6 147018 22977 90458446
Congestive cardiomyopathy 20.33 13.58 40 146984 7314 90474109
Non-small cell lung cancer metastatic 20.31 13.58 14 147010 804 90480619
Jugular vein thrombosis 20.29 13.58 27 146997 3554 90477869
Colitis ulcerative 20.29 13.58 42 146982 60224 90421199
Microangiopathy 20.29 13.58 19 147005 1696 90479727
Birdshot chorioretinopathy 20.24 13.58 7 147017 83 90481340
Diabetic retinal oedema 20.23 13.58 11 147013 411 90481012
Chemotherapy toxicity attenuation 20.22 13.58 5 147019 15 90481408
Pustular psoriasis 20.19 13.58 3 147021 18553 90462870
Aneurysm 20.18 13.58 27 146997 3573 90477850
Nodular regenerative hyperplasia 20.12 13.58 13 147011 670 90480753
Hypophagia 20.09 13.58 113 146911 35824 90445599
Metastases to vagina 19.98 13.58 5 147019 16 90481407
Haemorrhage intracranial 19.92 13.58 62 146962 15100 90466323
Shock haemorrhagic 19.87 13.58 54 146970 12191 90469232
Trichomegaly 19.79 13.58 7 147017 89 90481334
Sneezing 19.71 13.58 12 147012 29857 90451566
Gamma-glutamyltransferase increased 19.70 13.58 117 146907 37835 90443588
Joint effusion 19.66 13.58 4 147020 19706 90461717
PIK3CA-activated mutation 19.60 13.58 16 147008 1188 90480235
Anastomotic complication 19.56 13.58 10 147014 329 90481094
Recurrent cancer 19.55 13.58 22 147002 2437 90478986
Respiratory tract congestion 19.55 13.58 10 147014 27400 90454023
Adverse reaction 19.52 13.58 12 147012 29700 90451723
Candida test positive 19.48 13.58 15 147009 1024 90480399
Detachment of macular retinal pigment epithelium 19.47 13.58 4 147020 3 90481420
Acute pulmonary oedema 19.46 13.58 46 146978 9534 90471889
Retinal cyst 19.45 13.58 7 147017 94 90481329
Renal tubular disorder 19.45 13.58 25 146999 3182 90478241
Intracranial hypotension 19.34 13.58 10 147014 337 90481086
Lymphopenia 19.33 13.58 81 146943 22800 90458623
Therapy non-responder 19.29 13.58 136 146888 136568 90344855
Gastric varices haemorrhage 19.13 13.58 8 147016 164 90481259
Impaired work ability 19.12 13.58 4 147020 19322 90462101
Skin ulcer 19.11 13.58 143 146881 49932 90431491
Tumour inflammation 19.05 13.58 7 147017 100 90481323
Blood pressure fluctuation 18.97 13.58 35 146989 52378 90429045
Wound decomposition 18.92 13.58 5 147019 21 90481402
Failure to thrive 18.87 13.58 42 146982 8369 90473054
Radiation oesophagitis 18.80 13.58 11 147013 474 90480949
Brachiocephalic vein thrombosis 18.74 13.58 7 147017 105 90481318
Rhabdoid tumour 18.73 13.58 6 147018 55 90481368
Immune-mediated dermatitis 18.69 13.58 14 147010 917 90480506
Nephropathy toxic 18.67 13.58 54 146970 12634 90468789
Mental disorder 18.66 13.58 15 147009 32303 90449120
Procedural pain 18.63 13.58 16 147008 33344 90448079
Ankle fracture 18.61 13.58 5 147019 20365 90461058
Glioblastoma multiforme 18.59 13.58 14 147010 924 90480499
Immune-mediated pancreatitis 18.53 13.58 10 147014 368 90481055
Abscess 18.47 13.58 70 146954 18821 90462602
Embolism arterial 18.47 13.58 15 147009 1106 90480317
Subretinal fibrosis 18.44 13.58 7 147017 110 90481313
Infectious pleural effusion 18.43 13.58 19 147005 1906 90479517
Metastases to gastrointestinal tract 18.33 13.58 7 147017 112 90481311
Cardiac ventricular thrombosis 18.32 13.58 15 147009 1119 90480304
Soft tissue necrosis 18.25 13.58 13 147011 787 90480636
Fatigue 18.15 13.58 2137 144887 1151886 89329537
Onychalgia 18.09 13.58 15 147009 1139 90480284
Supraventricular tachycardia 18.06 13.58 63 146961 16273 90465150
Wound evisceration 18.05 13.58 4 147020 6 90481417
Incarcerated incisional hernia 18.05 13.58 5 147019 26 90481397
Exudative retinopathy 18.05 13.58 4 147020 6 90481417
Diabetes mellitus 18.04 13.58 50 146974 64825 90416598
Hepatic haemorrhage 17.97 13.58 12 147012 654 90480769
Short-bowel syndrome 17.78 13.58 12 147012 666 90480757
Carbohydrate antigen 19-9 increased 17.74 13.58 9 147015 291 90481132
Breast necrosis 17.74 13.58 8 147016 198 90481225
Nail discolouration 17.69 13.58 24 147000 3218 90478205
Metastases to eye 17.63 13.58 8 147016 201 90481222
Peripheral paralysis 17.62 13.58 7 147017 125 90481298
Meningitis 17.53 13.58 41 146983 8440 90472983
Sinus disorder 17.50 13.58 18 147006 34429 90446994
Cholinergic syndrome 17.49 13.58 12 147012 684 90480739
Affect lability 17.34 13.58 4 147020 18059 90463364
Application site recall reaction 17.32 13.58 4 147020 8 90481415
Psoas abscess 17.31 13.58 12 147012 696 90480727
Catheter site injury 17.30 13.58 9 147015 307 90481116
Vision blurred 17.25 13.58 263 146761 110030 90371393
Portal hypertensive gastropathy 17.23 13.58 14 147010 1033 90480390
Aggression 17.20 13.58 11 147013 26657 90454766
Pulmonary cavitation 17.18 13.58 14 147010 1037 90480386
Hypoglycaemia 17.16 13.58 57 146967 69791 90411632
Hyperhidrosis 17.16 13.58 140 146884 136165 90345258
Peripheral ischaemia 17.11 13.58 32 146992 5635 90475788
Venoocclusive liver disease 17.05 13.58 33 146991 5960 90475463
Hepatic vein stenosis 17.04 13.58 5 147019 33 90481390
Product dose omission in error 16.99 13.58 6 147018 20497 90460926
Hypotony of eye 16.96 13.58 8 147016 220 90481203
Subclavian vein thrombosis 16.94 13.58 19 147005 2097 90479326
Liver disorder 16.94 13.58 121 146903 121148 90360275
Acute hepatic failure 16.88 13.58 77 146947 22484 90458939
Thrombophlebitis 16.80 13.58 29 146995 4799 90476624
Rash papular 16.79 13.58 6 147018 20349 90461074
Palmar erythema 16.76 13.58 18 147006 1893 90479530
Budd-Chiari syndrome 16.71 13.58 6 147018 80 90481343
Retinal fibrosis 16.71 13.58 4 147020 10 90481413
Metastases to spleen 16.64 13.58 8 147016 230 90481193
Angioedema 16.59 13.58 52 146972 64824 90416599
Toxic cardiomyopathy 16.58 13.58 9 147015 335 90481088
Mesenteric neoplasm 16.55 13.58 5 147019 37 90481386
Vesical fistula 16.54 13.58 7 147017 148 90481275
Ulcerative keratitis 16.52 13.58 24 147000 3429 90477994
Colon cancer 16.51 13.58 47 146977 10897 90470526
Gastrointestinal stoma complication 16.50 13.58 20 147004 2399 90479024
Cancer pain 16.46 13.58 26 146998 3999 90477424
Radiotherapy 16.45 13.58 13 147011 922 90480501
Acquired amegakaryocytic thrombocytopenia 16.43 13.58 5 147019 38 90481385
Venous oxygen saturation increased 16.43 13.58 5 147019 38 90481385
Influenza like illness 16.42 13.58 71 146953 80540 90400883
Glomerulonephritis membranoproliferative 16.41 13.58 9 147015 342 90481081
Intercepted product preparation error 16.34 13.58 15 147009 1305 90480118
Immune-mediated myocarditis 16.29 13.58 15 147009 1310 90480113
Cyclitis 16.28 13.58 3 147021 0 90481423
Instillation site complication 16.28 13.58 3 147021 0 90481423
Cement embolism 16.28 13.58 3 147021 0 90481423
Retinal telangiectasia 16.28 13.58 3 147021 0 90481423
Wound necrosis 16.21 13.58 10 147014 475 90480948
Post procedural bile leak 16.20 13.58 7 147017 156 90481267
Hypotension 16.15 13.58 403 146621 324994 90156429
Heart rate increased 16.09 13.58 112 146912 112790 90368633
Depressed mood 16.08 13.58 36 146988 50186 90431237
Pulmonary tumour thrombotic microangiopathy 16.06 13.58 6 147018 90 90481333
Gallbladder disorder 16.06 13.58 6 147018 19797 90461626
Gastrointestinal obstruction 16.03 13.58 15 147009 1337 90480086
Infusion site pain 15.98 13.58 6 147018 19732 90461691
Nervousness 15.97 13.58 19 147005 34037 90447386
Colorectal cancer recurrent 15.94 13.58 4 147020 13 90481410
Hypersplenism 15.90 13.58 9 147015 364 90481059
Small intestinal haemorrhage 15.85 13.58 19 147005 2252 90479171
Visual acuity tests abnormal 15.84 13.58 7 147017 165 90481258
White blood cell count 15.83 13.58 6 147018 94 90481329
Foot fracture 15.81 13.58 12 147012 26594 90454829
Tongue ulceration 15.78 13.58 26 146998 4142 90477281
Bronchopleural fistula 15.76 13.58 8 147016 259 90481164
Pneumocephalus 15.71 13.58 8 147016 261 90481162
Hypervolaemia 15.66 13.58 18 147006 32739 90448684
Paraneoplastic syndrome 15.64 13.58 11 147013 653 90480770
Mood swings 15.61 13.58 7 147017 20695 90460728
Pneumonia chlamydial 15.60 13.58 6 147018 98 90481325
Amaurosis 15.60 13.58 12 147012 818 90480605
Non-cardiac chest pain 15.57 13.58 34 146990 6687 90474736
Abdominal wound dehiscence 15.54 13.58 8 147016 267 90481156
Vaccination site pain 15.51 13.58 9 147015 382 90481041
Tumour cavitation 15.50 13.58 5 147019 47 90481376
Chondronecrosis 15.50 13.58 5 147019 47 90481376
Cognitive disorder 15.48 13.58 59 146965 69348 90412075
Immune-mediated hypophysitis 15.45 13.58 10 147014 517 90480906
Lymphadenopathy 15.42 13.58 127 146897 45648 90435775
Pelvic mass 15.40 13.58 15 147009 1406 90480017
Macular detachment 15.38 13.58 6 147018 102 90481321
Charles Bonnet syndrome 15.31 13.58 5 147019 49 90481374
Hydrothorax 15.31 13.58 13 147011 1020 90480403
Blood magnesium decreased 15.22 13.58 58 146966 15635 90465788
Nephritic syndrome 15.17 13.58 9 147015 398 90481025
Rectal cancer metastatic 15.14 13.58 8 147016 282 90481141
White blood cell count increased 15.10 13.58 57 146967 67184 90414239
Coronary artery stenosis 14.99 13.58 29 146995 5237 90476186
Biliary tract disorder 14.98 13.58 12 147012 868 90480555
Glomerulonephropathy 14.96 13.58 6 147018 110 90481313
Varicose vein ruptured 14.96 13.58 5 147019 53 90481370
Uterine adhesions 14.96 13.58 5 147019 53 90481370
Tendonitis 14.94 13.58 8 147016 21364 90460059
Breast cancer female 14.89 13.58 3 147021 14883 90466540
Cutaneous tuberculosis 14.83 13.58 7 147017 193 90481230
Secondary hypertension 14.81 13.58 8 147016 295 90481128
Periodontal disease 14.80 13.58 16 147008 1696 90479727
Burkholderia pseudomallei infection 14.79 13.58 5 147019 55 90481368
Intercepted medication error 14.77 13.58 12 147012 885 90480538
Macular pigmentation 14.74 13.58 4 147020 19 90481404
Implant site dehiscence 14.74 13.58 4 147020 19 90481404
Vascular pseudoaneurysm 14.71 13.58 16 147008 1707 90479716
Open angle glaucoma 14.64 13.58 8 147016 302 90481121
Lymphorrhoea 14.63 13.58 5 147019 57 90481366
Vitreal cells 14.57 13.58 6 147018 118 90481305
Trichiasis 14.53 13.58 6 147018 119 90481304
Bone density decreased 14.50 13.58 5 147019 17340 90464083
Serositis 14.46 13.58 14 147010 1303 90480120
Keratic precipitates 14.33 13.58 8 147016 315 90481108
Mean cell haemoglobin increased 14.30 13.58 24 147000 3881 90477542
Panniculitis 14.29 13.58 3 147021 14455 90466968
Pseudocyst 14.25 13.58 7 147017 211 90481212
Immune-mediated hypothyroidism 14.24 13.58 15 147009 1543 90479880
Pneumothorax spontaneous 14.23 13.58 12 147012 933 90480490
Cytoreductive surgery 14.20 13.58 3 147021 3 90481420
Retinopathy proliferative 14.18 13.58 5 147019 63 90481360
Ulcerative gastritis 14.18 13.58 5 147019 63 90481360
Musculoskeletal chest pain 14.16 13.58 76 146948 23674 90457749
Injection site haemorrhage 14.15 13.58 15 147009 28303 90453120
Therapy responder 14.08 13.58 8 147016 326 90481097
Procedural site reaction 14.06 13.58 8 147016 327 90481096
Blood pressure systolic abnormal 14.05 13.58 7 147017 19471 90461952
Rash vesicular 13.96 13.58 6 147018 18191 90463232
Taste disorder 13.93 13.58 52 146972 61494 90419929
Acute lymphocytic leukaemia 13.93 13.58 20 147004 2828 90478595
Respiratory tract haemorrhage 13.93 13.58 9 147015 464 90480959
Punctate keratitis 13.86 13.58 11 147013 785 90480638
Loss of consciousness 13.82 13.58 153 146871 140085 90341338
Uterine fistula 13.82 13.58 4 147020 25 90481398
Retinal occlusive vasculitis 13.81 13.58 7 147017 226 90481197
Dystonia 13.80 13.58 5 147019 16814 90464609
Kidney infection 13.79 13.58 13 147011 25903 90455520
EGFR gene mutation 13.73 13.58 8 147016 342 90481081
Abnormal behaviour 13.71 13.58 10 147014 22618 90458805
Polypoidal choroidal vasculopathy 13.70 13.58 5 147019 70 90481353
Retroperitoneal abscess 13.70 13.58 7 147017 230 90481193
Septic shock 13.67 13.58 202 146822 83958 90397465
Drug-induced liver injury 13.67 13.58 88 146936 90230 90391193
Dysphagia 13.64 13.58 257 146767 112021 90369402
Intracardiac thrombus 13.61 13.58 18 147006 2356 90479067

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 2465.19 13.38 2471 115165 141185 42362514
Proteinuria 1388.30 13.38 837 116799 22146 42481553
Off label use 1380.94 13.38 4359 113277 633976 41869723
Death 1358.89 13.38 3571 114065 467614 42036085
Gastrointestinal perforation 785.93 13.38 336 117300 4150 42499549
Endophthalmitis 730.59 13.38 318 117318 4115 42499584
Palmar-plantar erythrodysaesthesia syndrome 530.51 13.38 446 117190 20136 42483563
Myelosuppression 481.54 13.38 576 117060 39885 42463814
Hypertension 410.57 13.38 1200 116436 166004 42337695
Drug interaction 400.75 13.38 120 117516 266879 42236820
Neuropathy peripheral 381.92 13.38 858 116778 100995 42402704
Intestinal perforation 310.18 13.38 250 117386 10624 42493075
Diarrhoea 306.53 13.38 2245 115391 458604 42045095
Oesophageal varices haemorrhage 302.74 13.38 163 117473 3444 42500255
Drug effective for unapproved indication 299.05 13.38 201 117435 6432 42497267
Metastases to lung 291.10 13.38 246 117390 11178 42492521
Tumour haemorrhage 284.82 13.38 157 117479 3481 42500218
Interstitial lung disease 275.20 13.38 644 116992 77818 42425881
Large intestine perforation 267.25 13.38 217 117419 9319 42494380
Macular oedema 262.97 13.38 148 117488 3421 42500278
Epistaxis 262.75 13.38 574 117062 66252 42437447
Suspected transmission of an infectious agent via product 262.74 13.38 99 117537 855 42502844
Neoplasm progression 260.15 13.38 359 117277 28641 42475058
Metastases to liver 258.69 13.38 270 117366 16056 42487643
No adverse event 254.26 13.38 416 117220 38605 42465094
Toxicity to various agents 250.73 13.38 162 117474 228974 42274725
Peritonitis 246.14 13.38 280 117356 18353 42485346
Nephrotic syndrome 245.61 13.38 199 117437 8519 42495180
Completed suicide 234.06 13.38 7 117629 96458 42407241
Varices oesophageal 232.86 13.38 147 117489 4218 42499481
Ascites 230.97 13.38 494 117142 56184 42447515
Drug ineffective 228.65 13.38 932 116704 629265 41874434
Product dose omission issue 219.56 13.38 76 117560 154289 42349410
Tumour perforation 211.50 13.38 72 117564 447 42503252
Stomatitis 203.14 13.38 437 117199 49892 42453807
Decreased appetite 195.33 13.38 1049 116587 192088 42311611
Overdose 190.45 13.38 31 117605 105233 42398466
Condition aggravated 185.85 13.38 270 117366 260484 42243215
Bone marrow failure 176.54 13.38 323 117313 32770 42470929
Portal hypertension 166.92 13.38 124 117512 4663 42499036
Anastomotic leak 166.01 13.38 67 117569 707 42502992
Small intestinal perforation 156.76 13.38 99 117537 2842 42500857
Bacterial endophthalmitis 154.60 13.38 41 117595 86 42503613
Subretinal fluid 151.42 13.38 62 117574 681 42503018
Vitreous floaters 150.70 13.38 111 117525 4119 42499580
Intestinal obstruction 142.24 13.38 263 117373 26895 42476804
Visual acuity reduced 140.75 13.38 206 117430 17344 42486355
Wound dehiscence 140.55 13.38 102 117534 3698 42500001
Protein urine 139.73 13.38 64 117572 940 42502759
Pulmonary embolism 134.84 13.38 670 116966 118942 42384757
Tumour necrosis 134.36 13.38 73 117563 1571 42502128
Malignant neoplasm progression 132.86 13.38 622 117014 107778 42395921
Hospitalisation 131.96 13.38 23 117613 74307 42429392
Rectal perforation 129.58 13.38 51 117585 501 42503198
Portal vein thrombosis 128.47 13.38 104 117532 4445 42499254
Injection site pain 127.68 13.38 8 117628 57790 42445909
Metastases to central nervous system 127.33 13.38 150 117486 10205 42493494
Neutrophil count decreased 125.56 13.38 423 117213 62992 42440707
Neutropenia 122.34 13.38 955 116681 198476 42305223
Mucosal inflammation 122.33 13.38 356 117280 49018 42454681
Intentional product misuse 119.46 13.38 15 117621 61885 42441814
Metastases to peritoneum 117.11 13.38 77 117559 2372 42501327
Adrenal insufficiency 112.88 13.38 194 117442 18730 42484969
Gastrointestinal toxicity 112.44 13.38 91 117545 3888 42499811
Dehydration 112.05 13.38 722 116914 141045 42362654
Necrotising fasciitis 109.89 13.38 95 117541 4451 42499248
Dizziness 109.55 13.38 339 117297 248915 42254784
Suicidal ideation 108.41 13.38 6 117630 48155 42455544
Retinal oedema 108.02 13.38 53 117583 915 42502784
Vitreous haemorrhage 106.78 13.38 76 117560 2671 42501028
Protein urine present 106.64 13.38 104 117532 5697 42498002
Retinal haemorrhage 105.24 13.38 103 117533 5667 42498032
Varicose vein ruptured 103.27 13.38 29 117607 82 42503617
Drug reaction with eosinophilia and systemic symptoms 102.21 13.38 3 117633 42072 42461627
Neurotoxicity 100.74 13.38 210 117426 23441 42480258
Skin toxicity 99.61 13.38 106 117530 6443 42497256
Hepatic function abnormal 98.57 13.38 340 117296 51227 42452472
Detachment of retinal pigment epithelium 98.02 13.38 43 117593 567 42503132
Suture rupture 97.80 13.38 40 117596 438 42503261
Incorrect dose administered 97.13 13.38 15 117621 52959 42450740
Feeling abnormal 94.67 13.38 37 117599 69749 42433950
Joint swelling 94.05 13.38 35 117601 67987 42435712
Rheumatoid arthritis 93.36 13.38 6 117630 42434 42461265
Neoplasm 92.29 13.38 100 117536 6205 42497494
Perforation 92.26 13.38 39 117597 467 42503232
Pneumothorax 92.17 13.38 202 117434 23341 42480358
Electrocardiogram QT prolonged 91.59 13.38 12 117624 47933 42455766
Fall 91.39 13.38 336 117300 234184 42269515
Product use in unapproved indication 91.21 13.38 237 117399 184219 42319480
Anxiety 91.12 13.38 116 117520 118444 42385255
Carcinoembryonic antigen increased 90.85 13.38 46 117590 852 42502847
Pruritus 90.73 13.38 246 117390 188525 42315174
Fatigue 90.11 13.38 1694 115942 433947 42069752
Haemorrhage 89.74 13.38 368 117268 60195 42443504
Anastomotic complication 89.52 13.38 37 117599 417 42503282
Impaired healing 89.10 13.38 165 117471 16888 42486811
Hepatic failure 88.93 13.38 269 117367 37831 42465868
COVID-19 88.53 13.38 114 117522 115834 42387865
Plasma cell myeloma 88.31 13.38 13 117623 47565 42456134
Stomal varices 88.24 13.38 27 117609 112 42503587
Rhabdomyolysis 88.15 13.38 53 117583 77966 42425733
Increased insulin requirement 87.67 13.38 27 117609 115 42503584
Bradycardia 84.72 13.38 67 117569 85417 42418282
Therapy partial responder 84.37 13.38 177 117459 19844 42483855
Hypothyroidism 83.98 13.38 236 117400 31848 42471851
Tumour rupture 82.80 13.38 33 117603 336 42503363
Musculoskeletal stiffness 82.80 13.38 28 117608 57737 42445962
Arthralgia 82.63 13.38 290 117346 204948 42298751
Vomiting 82.17 13.38 1187 116449 288536 42215163
Aggression 82.12 13.38 12 117624 44151 42459548
Haematotoxicity 81.01 13.38 124 117512 10861 42492838
Tremor 80.71 13.38 89 117547 96840 42406859
Asthma 79.77 13.38 36 117600 62278 42441421
Thrombotic microangiopathy 79.72 13.38 145 117491 14637 42489062
Metastases to bone 79.53 13.38 145 117491 14664 42489035
Embolism 79.32 13.38 109 117527 8654 42495045
Oesophagobronchial fistula 78.72 13.38 27 117609 172 42503527
Radiation necrosis 78.35 13.38 29 117607 237 42503462
Alopecia 78.25 13.38 217 117419 29059 42474640
Ileal perforation 77.78 13.38 44 117592 1027 42502672
Thrombocytopenia 77.31 13.38 834 116802 189445 42314254
Large intestinal obstruction 76.63 13.38 52 117584 1690 42502009
Stoma site haemorrhage 75.98 13.38 44 117592 1075 42502624
Glomerular vascular disorder 74.17 13.38 24 117612 124 42503575
Disseminated intravascular coagulation 73.54 13.38 191 117445 24603 42479096
Optical coherence tomography abnormal 73.32 13.38 25 117611 156 42503543
Ileus 72.42 13.38 162 117474 18977 42484722
Hepatic encephalopathy 72.38 13.38 148 117488 16294 42487405
Peripheral swelling 70.72 13.38 87 117549 90183 42413516
Loss of personal independence in daily activities 69.93 13.38 25 117611 49791 42453908
Duodenal perforation 69.72 13.38 48 117588 1598 42502101
Enteritis 68.64 13.38 114 117522 10702 42492997
Hallucination 67.90 13.38 37 117599 57470 42446229
Blindness 67.83 13.38 152 117484 17826 42485873
Wrong technique in product usage process 67.83 13.38 17 117619 42618 42461081
Tumour thrombosis 67.79 13.38 25 117611 202 42503497
Nausea 67.39 13.38 1499 116137 395300 42108399
Metastases to meninges 66.59 13.38 50 117586 1911 42501788
Vitritis 66.46 13.38 42 117594 1207 42502492
Metastasis 66.04 13.38 73 117563 4632 42499067
Acute kidney injury 65.99 13.38 672 116964 366665 42137034
Deep vein thrombosis 65.74 13.38 400 117236 76557 42427142
Inappropriate schedule of product administration 65.54 13.38 102 117534 95800 42407899
Accidental overdose 65.43 13.38 3 117633 28327 42475372
Eye inflammation 65.43 13.38 61 117575 3157 42500542
Sedation 65.03 13.38 5 117631 30470 42473229
Lactic acidosis 64.76 13.38 22 117614 45239 42458460
Failure to anastomose 64.75 13.38 24 117612 197 42503502
Drug dependence 64.33 13.38 4 117632 29090 42474609
Somnolence 63.26 13.38 190 117446 140915 42362784
Bleeding varicose vein 62.45 13.38 27 117609 343 42503356
Angioedema 61.91 13.38 20 117616 42457 42461242
Gastric perforation 61.68 13.38 58 117578 3035 42500664
Hypotension 61.64 13.38 437 117199 257194 42246505
Cardiac failure congestive 61.45 13.38 88 117548 85514 42418185
Depression 61.42 13.38 135 117501 111228 42392471
Colon cancer metastatic 61.15 13.38 45 117591 1667 42502032
Drug hypersensitivity 60.32 13.38 114 117522 99275 42404424
Enterocolitis 59.48 13.38 102 117534 9827 42493872
Wheezing 59.41 13.38 39 117597 54742 42448957
Liver carcinoma ruptured 59.07 13.38 24 117612 258 42503441
Full blood count abnormal 58.22 13.38 7 117629 29869 42473830
Cystoid macular oedema 58.15 13.38 36 117600 997 42502702
Dermatitis acneiform 57.97 13.38 88 117548 7651 42496048
Adverse drug reaction 57.51 13.38 16 117620 37418 42466281
Performance status decreased 57.41 13.38 68 117568 4652 42499047
Retinal thickening 56.75 13.38 26 117610 382 42503317
Psychotic disorder 56.53 13.38 7 117629 29201 42474498
Cholangitis 56.30 13.38 104 117532 10623 42493076
Urticaria 56.27 13.38 73 117563 73963 42429736
Hypopyon 55.87 13.38 28 117608 507 42503192
Retinal detachment 55.83 13.38 79 117557 6446 42497253
Muscle spasms 55.53 13.38 95 117541 85949 42417750
Colorectal cancer metastatic 55.39 13.38 34 117602 927 42502772
Abdominal pain 55.33 13.38 784 116852 189687 42314012
Macular fibrosis 54.96 13.38 25 117611 361 42503338
Influenza 54.08 13.38 55 117581 62120 42441579
Fistula 53.74 13.38 86 117550 7826 42495873
Agitation 53.58 13.38 59 117577 64255 42439444
Polyneuropathy 53.55 13.38 142 117494 18519 42485180
Platelet count decreased 52.83 13.38 600 117036 137981 42365718
Pain in extremity 52.72 13.38 225 117411 150379 42353320
Treatment noncompliance 52.71 13.38 19 117617 37653 42466046
Blood glucose increased 52.66 13.38 76 117560 73623 42430076
Alpha 1 foetoprotein increased 52.58 13.38 30 117606 712 42502987
Retinal pigment epithelial tear 51.91 13.38 23 117613 311 42503388
Contraindicated product administered 51.59 13.38 5 117631 25267 42478432
Eczema 51.56 13.38 15 117621 34071 42469628
Abdominal discomfort 51.45 13.38 80 117556 75175 42428524
Peripheral sensory neuropathy 51.17 13.38 89 117547 8673 42495026
Suspected counterfeit product 51.07 13.38 23 117613 324 42503375
Myalgia 50.92 13.38 119 117517 95961 42407738
Psoriatic arthropathy 50.81 13.38 5 117631 24962 42478737
Intracranial tumour haemorrhage 50.78 13.38 24 117612 380 42503319
Arteriospasm coronary 50.72 13.38 64 117572 4674 42499025
Venous thrombosis 50.52 13.38 59 117577 3976 42499723
Weight increased 50.12 13.38 143 117493 107840 42395859
Gastrointestinal anastomotic leak 50.07 13.38 27 117609 572 42503127
Prostate cancer 49.47 13.38 31 117605 44612 42459087
Pneumatosis intestinalis 48.99 13.38 63 117573 4689 42499010
Hiccups 48.28 13.38 105 117531 12066 42491633
Cerebral infarction 48.22 13.38 192 117444 30977 42472722
Coma 48.16 13.38 46 117590 53508 42450191
Cataract nuclear 47.99 13.38 29 117607 768 42502931
Palpitations 47.62 13.38 42 117594 50755 42452944
Drug withdrawal syndrome 47.53 13.38 3 117633 21546 42482153
Colitis 46.93 13.38 253 117383 46319 42457380
Drug level increased 46.72 13.38 8 117628 26192 42477507
Rectal cancer metastatic 46.69 13.38 20 117616 248 42503451
Gastric varices 46.50 13.38 27 117609 663 42503036
Metastases to adrenals 46.35 13.38 32 117604 1070 42502629
Chronic obstructive pulmonary disease 46.17 13.38 64 117572 63050 42440649
Fluid retention 45.88 13.38 15 117621 31604 42472095
Psoriasis 45.78 13.38 40 117596 48564 42455135
Fistula of small intestine 45.76 13.38 26 117610 612 42503087
Aortic dissection 45.44 13.38 49 117587 3023 42500676
Hepatic lesion 45.43 13.38 59 117577 4435 42499264
Therapeutic product effect incomplete 45.15 13.38 79 117557 70860 42432839
Basal cell carcinoma 45.11 13.38 5 117631 22728 42480971
Tracheal fistula 44.99 13.38 17 117619 148 42503551
Choroidal neovascularisation 44.97 13.38 20 117616 273 42503426
Sleep apnoea syndrome 44.84 13.38 4 117632 21604 42482095
Hypoglycaemia 44.48 13.38 60 117576 59794 42443905
Bronchitis 44.27 13.38 39 117597 47162 42456537
Asthenia 44.19 13.38 1050 116586 279743 42223956
Metastatic neoplasm 43.99 13.38 51 117585 3410 42500289
Injection site erythema 43.98 13.38 3 117633 20192 42483507
Wound infection 43.90 13.38 81 117555 8265 42495434
Hemiparesis 43.69 13.38 126 117510 17250 42486449
Disturbance in attention 43.63 13.38 14 117622 29852 42473847
Eye haemorrhage 43.60 13.38 60 117576 4770 42498929
Hyperammonaemia 43.48 13.38 78 117558 7788 42495911
Cardiogenic shock 43.44 13.38 22 117614 35618 42468081
Haemoptysis 43.31 13.38 246 117390 45921 42457778
Abnormal behaviour 43.14 13.38 10 117626 26441 42477258
Peritoneal disorder 43.11 13.38 20 117616 303 42503396
Malignant ascites 43.09 13.38 25 117611 613 42503086
Insomnia 43.03 13.38 174 117462 118079 42385620
Pseudoendophthalmitis 42.54 13.38 14 117622 77 42503622
Immune thrombocytopenia 42.50 13.38 95 117541 11121 42492578
Product prescribing error 42.34 13.38 10 117626 26102 42477597
Hepatic rupture 42.28 13.38 13 117623 55 42503644
Intentional product use issue 42.27 13.38 341 117295 71492 42432207
Osteonecrosis of jaw 42.12 13.38 132 117504 18917 42484782
Stress 42.11 13.38 36 117600 44176 42459523
Eosinophilia 42.10 13.38 19 117617 32880 42470819
Irritability 41.42 13.38 13 117623 28115 42475584
Small intestinal obstruction 41.26 13.38 122 117514 16939 42486760
Cardiac arrest 40.96 13.38 159 117477 109161 42394538
Pelvic abscess 40.82 13.38 29 117607 1016 42502683
Coronary artery disease 40.78 13.38 53 117583 53667 42450032
Drug intolerance 40.72 13.38 102 117534 80322 42423377
Ciliary hyperaemia 40.58 13.38 11 117625 26 42503673
Restlessness 40.50 13.38 15 117621 29234 42474465
Retinal vascular disorder 40.40 13.38 17 117619 201 42503498
Acral peeling skin syndrome 40.38 13.38 12 117624 44 42503655
Diabetic retinopathy 39.83 13.38 38 117598 2025 42501674
Gout 39.51 13.38 14 117622 28041 42475658
Therapy interrupted 39.22 13.38 7 117629 22243 42481456
Embolism arterial 39.03 13.38 26 117610 819 42502880
Bronchial fistula 38.97 13.38 17 117619 221 42503478
Cellulitis 38.81 13.38 69 117567 61516 42442183
Sinusitis 38.71 13.38 44 117592 47248 42456451
Eastern Cooperative Oncology Group performance status worsened 38.69 13.38 31 117605 1305 42502394
Subileus 38.39 13.38 48 117588 3473 42500226
Bronchiectasis 38.32 13.38 3 117633 18016 42485683
Metamorphopsia 38.17 13.38 23 117613 606 42503093
Nasal septum perforation 38.16 13.38 17 117619 233 42503466
Respiratory depression 37.82 13.38 4 117632 18864 42484835
Anastomotic fistula 37.36 13.38 13 117623 87 42503612
Migraine 36.97 13.38 12 117624 25402 42478297
Medication error 36.77 13.38 23 117613 33131 42470568
Tumour marker increased 36.66 13.38 25 117611 819 42502880
Metastases to lymph nodes 36.43 13.38 62 117574 5936 42497763
Cytomegalovirus infection 36.40 13.38 22 117614 32284 42471415
Microangiopathy 36.37 13.38 33 117603 1649 42502050
Pharyngeal necrosis 36.02 13.38 12 117624 69 42503630
Pyrexia 35.85 13.38 1377 116259 392665 42111034
Transmission of an infectious agent via product 35.83 13.38 15 117621 175 42503524
Macular hole 35.81 13.38 18 117618 328 42503371
Injection site swelling 35.61 13.38 3 117633 16970 42486729
Pneumonia 35.45 13.38 891 116745 421258 42082441
Toxic epidermal necrolysis 34.94 13.38 15 117621 26735 42476964
Glioblastoma 34.71 13.38 30 117606 1405 42502294
Non-infectious endophthalmitis 33.98 13.38 16 117620 251 42503448
Multiple organ dysfunction syndrome 33.92 13.38 145 117491 96890 42406809
Perirectal abscess 33.87 13.38 33 117603 1805 42501894
Adrenocorticotropic hormone deficiency 33.86 13.38 29 117607 1341 42502358
Myocarditis 33.70 13.38 122 117514 18816 42484883
Blindness transient 33.62 13.38 40 117596 2749 42500950
Dyskinesia 33.54 13.38 14 117622 25376 42478323
Bile duct stenosis 33.54 13.38 29 117607 1359 42502340
Hot flush 33.51 13.38 10 117626 22341 42481358
Uveitis 33.50 13.38 77 117559 9181 42494518
Rectal ulcer 33.41 13.38 27 117609 1151 42502548
Diverticular perforation 33.30 13.38 46 117590 3670 42500029
Dysphonia 33.15 13.38 161 117475 28289 42475410
Oesophageal haemorrhage 33.07 13.38 29 117607 1385 42502314
Vascular pseudoaneurysm 32.86 13.38 39 117597 2673 42501026
Tractional retinal detachment 32.58 13.38 10 117626 42 42503657
Cardiac disorder 32.51 13.38 53 117583 48879 42454820
Vitreous detachment 32.50 13.38 25 117611 991 42502708
Leukoencephalopathy 32.49 13.38 53 117583 4901 42498798
Visual impairment 32.42 13.38 217 117419 42896 42460803
Type 1 diabetes mellitus 32.38 13.38 56 117580 5431 42498268
Granulocyte count decreased 32.38 13.38 30 117606 1540 42502159
Intestinal metastasis 32.36 13.38 17 117619 341 42503358
Change of bowel habit 32.28 13.38 26 117610 1103 42502596
Retinal exudates 32.17 13.38 23 117613 814 42502885
Urinary occult blood 32.17 13.38 9 117627 25 42503674
Colitis ulcerative 32.14 13.38 16 117620 26159 42477540
Tumour pseudoprogression 31.77 13.38 25 117611 1025 42502674
Colorectal cancer recurrent 31.69 13.38 11 117625 73 42503626
Posterior reversible encephalopathy syndrome 31.30 13.38 92 117544 12729 42490970
Pulmonary artery thrombosis 31.09 13.38 23 117613 859 42502840
Illness 30.97 13.38 15 117621 24915 42478784
Haemobilia 30.96 13.38 18 117618 443 42503256
Swollen tongue 30.93 13.38 10 117626 21221 42482478
Anaemia of malignant disease 30.82 13.38 19 117617 522 42503177
Hyperhidrosis 30.57 13.38 137 117499 90375 42413324
Anterior chamber inflammation 30.43 13.38 17 117619 387 42503312
Oesophagitis 30.40 13.38 102 117534 15145 42488554
Osteoporosis 30.29 13.38 3 117633 14903 42488796
Constipation 30.27 13.38 622 117014 161669 42342030
Venous thrombosis limb 30.26 13.38 35 117601 2334 42501365
Hyperbilirubinaemia 30.23 13.38 125 117511 20510 42483189
Gastric varices haemorrhage 30.16 13.38 15 117621 267 42503432
Cerebral ischaemia 29.87 13.38 62 117574 6897 42496802
Anal fistula 29.83 13.38 58 117578 6155 42497544
Osteonecrosis 29.77 13.38 104 117532 15761 42487938
Poisoning 29.76 13.38 3 117633 14696 42489003
EGFR gene mutation 29.71 13.38 14 117622 220 42503479
Labelled drug-drug interaction medication error 29.51 13.38 4 117632 15578 42488121
Synovitis 29.48 13.38 4 117632 15563 42488136
Infectious pleural effusion 29.31 13.38 40 117596 3155 42500544
Retinal disorder 29.30 13.38 25 117611 1150 42502549
Clostridium difficile colitis 29.25 13.38 11 117625 21241 42482458
Gene mutation 29.18 13.38 30 117606 1751 42501948
Azotaemia 29.17 13.38 56 117580 5888 42497811
Therapy cessation 29.15 13.38 10 117626 20440 42483259
Myoclonus 28.74 13.38 6 117630 17059 42486640
Subretinal fibrosis 28.70 13.38 11 117625 100 42503599
Bronchopulmonary aspergillosis 28.57 13.38 9 117627 19420 42484279
International normalised ratio increased 28.55 13.38 56 117580 48112 42455587
Insulin autoimmune syndrome 28.55 13.38 18 117618 515 42503184
Acquired gene mutation 28.43 13.38 28 117608 1552 42502147
Loss of consciousness 28.15 13.38 145 117491 92209 42411490
Portal hypertensive gastropathy 27.98 13.38 21 117615 802 42502897
Frequent bowel movements 27.97 13.38 12 117624 21395 42482304
Anal haemorrhage 27.93 13.38 37 117599 2836 42500863
Enterocutaneous fistula 27.78 13.38 25 117611 1236 42502463
Faecaluria 27.69 13.38 7 117629 11 42503688
Tumour fistulisation 27.60 13.38 11 117625 112 42503587
Clostridium difficile infection 27.60 13.38 14 117622 22645 42481054
End stage renal disease 27.53 13.38 6 117630 16552 42487147
Abdominal abscess 27.51 13.38 50 117586 5043 42498656
Pancytopenia 27.47 13.38 201 117435 117542 42386157
Duodenal ulcer perforation 27.46 13.38 29 117607 1747 42501952
Immune-mediated enterocolitis 27.26 13.38 53 117583 5624 42498075
Nasopharyngitis 27.26 13.38 129 117507 83867 42419832
Hallucination, visual 27.12 13.38 12 117624 21008 42482691
Burning sensation 27.10 13.38 12 117624 21001 42482698
Chronic kidney disease 27.08 13.38 56 117580 47185 42456514
Ventricular tachycardia 27.00 13.38 26 117610 30134 42473565
Hypoferritinaemia 26.95 13.38 7 117629 13 42503686
Transplant rejection 26.93 13.38 3 117633 13585 42490114
Gastrointestinal necrosis 26.85 13.38 44 117592 4084 42499615
Diabetes mellitus 26.83 13.38 81 117555 60006 42443693
Incorrect route of product administration 26.76 13.38 17 117619 24288 42479411
Blister 26.65 13.38 22 117614 27468 42476231
Miosis 26.57 13.38 3 117633 13443 42490256
Prostatic specific antigen increased 26.43 13.38 7 117629 16918 42486781
General physical health deterioration 26.36 13.38 574 117062 150672 42353027
Thrombophlebitis migrans 26.33 13.38 15 117621 355 42503344
Macular scar 26.18 13.38 8 117628 33 42503666
Ocular discomfort 26.14 13.38 37 117599 3020 42500679
Macular ischaemia 26.09 13.38 12 117624 178 42503521
Intraocular pressure increased 26.09 13.38 56 117580 6377 42497322
Skin lesion 26.03 13.38 22 117614 27152 42476547
Neovascular age-related macular degeneration 26.01 13.38 13 117623 234 42503465
Ureteric compression 25.94 13.38 14 117622 297 42503402
Sleep disorder 25.93 13.38 59 117577 48036 42455663
Ocular hypertension 25.88 13.38 23 117613 1118 42502581
Mean cell haemoglobin increased 25.81 13.38 31 117605 2152 42501547
Retinal pigment epitheliopathy 25.76 13.38 13 117623 239 42503460
Proteus infection 25.70 13.38 25 117611 1365 42502334
Blood bilirubin increased 25.62 13.38 202 117434 42050 42461649
Stomal hernia 25.59 13.38 15 117621 375 42503324
Anterior chamber cell 25.56 13.38 16 117620 452 42503247
Hyperphosphataemia 25.45 13.38 3 117633 13001 42490698
Malignant glioma 25.45 13.38 8 117628 37 42503662
Prescribed overdose 25.26 13.38 3 117633 12924 42490775
Bladder perforation 25.25 13.38 14 117622 314 42503385
Pulmonary haemorrhage 25.21 13.38 79 117557 11318 42492381
Myositis 24.97 13.38 94 117542 14772 42488927
Retinal vein occlusion 24.86 13.38 29 117607 1952 42501747
Arthropathy 24.81 13.38 27 117609 29570 42474129
Tinnitus 24.70 13.38 26 117610 28912 42474787
Cutis laxa 24.65 13.38 10 117626 107 42503592
Proctalgia 24.58 13.38 58 117578 7035 42496664
Swelling 24.50 13.38 74 117562 54811 42448888
Induration 24.44 13.38 22 117614 1088 42502611
Nephrolithiasis 24.36 13.38 40 117596 36790 42466909
Immune-mediated hepatitis 24.24 13.38 40 117596 3734 42499965
Lymphoma 24.19 13.38 5 117631 14316 42489383
Embolism venous 24.08 13.38 28 117608 1878 42501821
Erectile dysfunction 24.07 13.38 20 117616 24893 42478806
Stoma site pain 24.04 13.38 19 117617 784 42502915
Blood cholesterol increased 24 13.38 23 117613 26718 42476981
Arthritis 24.00 13.38 50 117586 42015 42461684
Retinal vascular occlusion 23.96 13.38 12 117624 217 42503482
Retinal artery occlusion 23.84 13.38 30 117606 2185 42501514
Mouth ulceration 23.81 13.38 93 117543 14870 42488829
Myocardial infarction 23.79 13.38 223 117413 123786 42379913
Rectourethral fistula 23.70 13.38 7 117629 25 42503674
Wound complication 23.68 13.38 33 117603 2654 42501045
Therapeutic product effect decreased 23.65 13.38 45 117591 39105 42464594
Encephalitis 23.60 13.38 67 117569 9091 42494608
Dyspnoea 23.52 13.38 991 116645 441630 42062069
Pneumonitis 23.43 13.38 196 117440 41522 42462177
Tumour invasion 23.40 13.38 14 117622 364 42503335
Corneal disorder 23.34 13.38 21 117615 1038 42502661
Haematemesis 23.30 13.38 153 117483 30046 42473653
Hypoalbuminaemia 23.21 13.38 95 117541 15515 42488184
Magnetic resonance imaging head abnormal 23.19 13.38 25 117611 1542 42502157
Diabetic foot 23.10 13.38 35 117601 3038 42500661
Muscle rigidity 23.07 13.38 3 117633 12056 42491643
Hyperammonaemic encephalopathy 23.02 13.38 33 117603 2725 42500974
Enterovesical fistula 23.01 13.38 20 117616 944 42502755
Intravascular haemolysis 22.99 13.38 16 117620 542 42503157
Proctitis 22.89 13.38 34 117602 2899 42500800
Chest discomfort 22.88 13.38 94 117542 63522 42440177
Product administration error 22.84 13.38 11 117625 18332 42485367
Injury 22.72 13.38 17 117619 22299 42481400
Hypopituitarism 22.72 13.38 33 117603 2758 42500941
Rash pruritic 22.69 13.38 36 117600 33567 42470132
Productive cough 22.68 13.38 70 117566 51497 42452202
Acute abdomen 22.58 13.38 28 117608 2009 42501690
Cholecystitis 22.54 13.38 83 117553 12905 42490794
Hyperkalaemia 22.50 13.38 130 117506 80328 42423371
Jejunal perforation 22.25 13.38 13 117623 323 42503376
Encephalitis autoimmune 22.21 13.38 23 117613 1354 42502345
Hepatic atrophy 22.21 13.38 11 117625 194 42503505
Renal-limited thrombotic microangiopathy 21.93 13.38 12 117624 262 42503437
Type II hypersensitivity 21.87 13.38 8 117628 63 42503636
Subdural haematoma 21.84 13.38 19 117617 23119 42480580
Mean cell volume increased 21.81 13.38 39 117597 3884 42499815
Gallbladder rupture 21.80 13.38 18 117618 791 42502908
Full blood count decreased 21.80 13.38 15 117621 20545 42483154
Ill-defined disorder 21.78 13.38 96 117540 16200 42487499
Lymphangiosis carcinomatosa 21.75 13.38 20 117616 1017 42502682
Respiratory arrest 21.61 13.38 28 117608 28396 42475303
Aplastic anaemia 21.60 13.38 4 117632 12380 42491319
Cachexia 21.58 13.38 60 117576 8044 42495655
Obstructive airways disorder 21.41 13.38 22 117614 24737 42478962
Thrombotic thrombocytopenic purpura 21.38 13.38 38 117598 3766 42499933
Device related thrombosis 21.29 13.38 23 117613 1422 42502277
Joint injury 21.22 13.38 7 117629 14669 42489030
Aphonia 21.21 13.38 40 117596 4149 42499550
Lacrimation increased 21.13 13.38 76 117560 11682 42492017
Liver disorder 21.08 13.38 184 117452 39460 42464239
Metabolic acidosis 21 13.38 73 117563 51785 42451914
Immune-mediated encephalitis 20.87 13.38 16 117620 631 42503068
Unresponsive to stimuli 20.87 13.38 34 117602 31369 42472330
Glycosylated haemoglobin increased 20.85 13.38 5 117631 12919 42490780
Paronychia 20.77 13.38 40 117596 4215 42499484
Rectal adenocarcinoma 20.65 13.38 19 117617 967 42502732
Hypervolaemia 20.63 13.38 20 117616 23105 42480594
Head injury 20.54 13.38 16 117620 20566 42483133
Cardiac murmur 20.50 13.38 5 117631 12770 42490929
Cough 20.45 13.38 357 117279 177746 42325953
Nervousness 20.38 13.38 6 117630 13526 42490173
IIIrd nerve paralysis 20.37 13.38 15 117621 556 42503143
Headache 20.35 13.38 504 117132 238865 42264834
Appendicitis perforated 20.28 13.38 27 117609 2079 42501620
Upper respiratory tract infection 20.18 13.38 55 117581 42118 42461581
Blood glucose decreased 20.18 13.38 7 117629 14212 42489487
Road traffic accident 20.15 13.38 14 117622 19079 42484620
Colonic fistula 20.10 13.38 14 117622 475 42503224
Post procedural fistula 20.10 13.38 9 117627 125 42503574
Oxygen saturation decreased 20.03 13.38 101 117535 64586 42439113
Sudden death 20.02 13.38 95 117541 16534 42487165
Cytokine release syndrome 19.89 13.38 60 117576 44467 42459232
Xeroderma 19.86 13.38 10 117626 183 42503516
Incisional hernia 19.85 13.38 22 117614 1400 42502299
Vena cava thrombosis 19.83 13.38 23 117613 1538 42502161
Retinal aneurysm 19.78 13.38 9 117627 130 42503569
Blindness unilateral 19.70 13.38 45 117591 5343 42498356
Pelvic venous thrombosis 19.64 13.38 18 117618 911 42502788
Ciliary body disorder 19.58 13.38 4 117632 0 42503699
Nasal congestion 19.55 13.38 32 117604 29469 42474230
Retinal degeneration 19.50 13.38 16 117620 697 42503002
Prothrombin level decreased 19.47 13.38 20 117616 1166 42502533
Hypophysitis 19.46 13.38 32 117604 2979 42500720
Pulmonary fistula 19.45 13.38 8 117628 89 42503610
Acute coronary syndrome 19.43 13.38 87 117549 14778 42488921
Unevaluable event 19.35 13.38 41 117595 34247 42469452
Suture related complication 19.33 13.38 10 117626 194 42503505
Erythema multiforme 19.24 13.38 66 117570 9911 42493788
Neoplasm recurrence 19.04 13.38 30 117606 2694 42501005
Carbohydrate antigen 19-9 increased 19.02 13.38 11 117625 268 42503431
Central nervous system mass 19.00 13.38 17 117619 834 42502865
Respiratory distress 18.94 13.38 56 117580 41764 42461935
Wall motion score index abnormal 18.93 13.38 17 117619 838 42502861
Localised infection 18.90 13.38 17 117619 20356 42483343
Type 2 diabetes mellitus 18.89 13.38 14 117622 18457 42485242
Prescribed underdose 18.64 13.38 3 117633 10279 42493420
Dialysis 18.64 13.38 5 117631 11981 42491718
Osteoarthritis 18.60 13.38 24 117612 24381 42479318
Pulmonary oedema 18.36 13.38 80 117556 53192 42450507
Rash macular 18.34 13.38 12 117624 16879 42486820
Metastases to abdominal wall 18.34 13.38 8 117628 104 42503595
Abscess 18.33 13.38 83 117553 14165 42489534
Rectal tenesmus 18.20 13.38 19 117617 1129 42502570
Memory impairment 18.19 13.38 74 117562 50148 42453551
Airway remodelling 18.18 13.38 17 117619 883 42502816
Wound evisceration 18.13 13.38 8 117628 107 42503592
Diabetic retinal oedema 18.12 13.38 10 117626 222 42503477
Emotional distress 18.07 13.38 11 117625 16082 42487617
Haematoma 18.01 13.38 31 117605 27992 42475707
Underdose 17.88 13.38 12 117624 16654 42487045
Retinal tear 17.86 13.38 18 117618 1026 42502673
Neovascularisation 17.80 13.38 6 117630 36 42503663
Red blood cell sedimentation rate increased 17.76 13.38 3 117633 9921 42493778
Primary adrenal insufficiency 17.75 13.38 11 117625 305 42503394
Pneumoperitoneum 17.75 13.38 27 117609 2351 42501348
Nephritis 17.74 13.38 35 117601 3754 42499945
Mesenteric vein thrombosis 17.68 13.38 17 117619 915 42502784
Duodenal varices 17.59 13.38 5 117631 15 42503684
Leukopenia 17.56 13.38 297 117339 74449 42429250
Perihepatic abscess 17.56 13.38 8 117628 116 42503583
Medulloblastoma 17.50 13.38 7 117629 72 42503627
Anger 17.48 13.38 7 117629 13011 42490688
Peritoneal neoplasm 17.39 13.38 6 117630 39 42503660
Tongue geographic 17.35 13.38 4 117632 3 42503696
Laryngeal necrosis 17.35 13.38 5 117631 16 42503683
Cardiac septal defect 17.25 13.38 17 117619 943 42502756
Glomerular filtration rate decreased 17.24 13.38 12 117624 16339 42487360
Tumour compression 17.11 13.38 9 117627 181 42503518
Cholecystitis acute 17.08 13.38 53 117583 7553 42496146
Atopy 17.03 13.38 17 117619 958 42502741
Product substitution issue 17.02 13.38 5 117631 11285 42492414
Hypercreatinaemia 16.89 13.38 10 117626 255 42503444
Tachypnoea 16.82 13.38 21 117615 21641 42482058
Portal vein embolism 16.82 13.38 4 117632 4 42503695
Alpha 1 foetoprotein decreased 16.82 13.38 4 117632 4 42503695
Mechanical ileus 16.73 13.38 13 117623 523 42503176
Hypertensive crisis 16.70 13.38 64 117572 10142 42493557
Haemoglobin 16.66 13.38 6 117630 45 42503654
Immune-mediated hepatic disorder 16.63 13.38 27 117609 2487 42501212
Atrial fibrillation 16.60 13.38 278 117358 139315 42364384
Microangiopathic haemolytic anaemia 16.45 13.38 18 117618 1129 42502570
Panic attack 16.45 13.38 5 117631 11040 42492659
Metastases to spine 16.36 13.38 30 117606 3047 42500652
Protein induced by vitamin K absence or antagonist II increased 16.32 13.38 6 117630 48 42503651
Pseudocellulitis 16.28 13.38 10 117626 273 42503426
Fear 16.26 13.38 5 117631 10960 42492739
Adenocarcinoma of colon 16.19 13.38 34 117602 3813 42499886
Metastases to gastrointestinal tract 16.18 13.38 7 117629 89 42503610
Visual acuity tests abnormal 16.11 13.38 7 117629 90 42503609
Rash erythematous 16.00 13.38 41 117595 32050 42471649
Mental impairment 15.94 13.38 7 117629 12310 42491389
Angiogram retina abnormal 15.93 13.38 4 117632 6 42503693
Traumatic ulcer 15.93 13.38 5 117631 23 42503676
Pallor 15.92 13.38 35 117601 28851 42474848
Neuralgia 15.92 13.38 29 117607 25618 42478081
Retinal neovascularisation 15.91 13.38 8 117628 146 42503553
Bronchopleural fistula 15.89 13.38 14 117622 673 42503026
Lethargy 15.81 13.38 71 117565 46819 42456880
Thirst 15.76 13.38 3 117633 9105 42494594
Hypertensive encephalopathy 15.73 13.38 12 117624 470 42503229
Liver function test abnormal 15.68 13.38 42 117594 32349 42471350
Biliary fistula 15.65 13.38 7 117629 97 42503602
Oesophageal ulcer 15.56 13.38 33 117603 3726 42499973
Pulmonary infarction 15.49 13.38 20 117616 1494 42502205
Liver abscess 15.47 13.38 39 117597 4931 42498768
Exostosis of jaw 15.46 13.38 7 117629 100 42503599
Poor peripheral circulation 15.45 13.38 21 117615 1650 42502049
Urethritis 15.44 13.38 12 117624 483 42503216
Tumour cavitation 15.43 13.38 5 117631 26 42503673
Cranial nerve disorder 15.43 13.38 13 117623 588 42503111
Gingival bleeding 15.38 13.38 55 117581 8430 42495269
Retinal ischaemia 15.36 13.38 12 117624 487 42503212
Metastases to bladder 15.33 13.38 7 117629 102 42503597
Hypophagia 15.32 13.38 127 117509 26829 42476870
Mycotic endophthalmitis 15.29 13.38 9 117627 227 42503472
Non-small cell lung cancer metastatic 15.28 13.38 15 117621 828 42502871
Eczema impetiginous 15.27 13.38 5 117631 27 42503672
Gastroenteritis radiation 15.27 13.38 10 117626 306 42503393
Vitreoretinal traction syndrome 15.21 13.38 4 117632 8 42503691
Glioma 15.21 13.38 12 117624 494 42503205
Posterior capsule opacification 15.20 13.38 8 117628 161 42503538
Pain 15.19 13.38 538 117098 244310 42259389
Oral pain 15.19 13.38 72 117564 12524 42491175
Oesophageal carcinoma 15.16 13.38 4 117632 9692 42494007
Macular degeneration 15.08 13.38 26 117610 2515 42501184
Mood swings 15.08 13.38 3 117633 8823 42494876
Heart rate decreased 15.08 13.38 51 117585 36481 42467218
Activated partial thromboplastin time prolonged 15.08 13.38 13 117623 15890 42487809
Hepatic enzyme increased 15.03 13.38 70 117566 45714 42457985
Varicose vein 15.00 13.38 20 117616 1542 42502157
Gastric ulcer 15.00 13.38 94 117542 18168 42485531
Vitreal cells 14.98 13.38 6 117630 62 42503637
Heart rate increased 14.91 13.38 86 117550 53169 42450530
Corneal epithelium defect 14.87 13.38 11 117625 411 42503288
Right ventricular failure 14.83 13.38 4 117632 9551 42494148
Eye infection gonococcal 14.83 13.38 5 117631 30 42503669
Xanthoma 14.74 13.38 7 117629 112 42503587
Kidney transplant rejection 14.73 13.38 3 117633 8680 42495019
Glomerulonephritis membranoproliferative 14.72 13.38 12 117624 518 42503181
Glioblastoma multiforme 14.71 13.38 15 117621 867 42502832
Tumour hyperprogression 14.69 13.38 8 117628 173 42503526
Haemangioblastoma 14.69 13.38 3 117633 0 42503699
Cyclitis 14.69 13.38 3 117633 0 42503699
Arterioenteric fistula 14.69 13.38 3 117633 0 42503699
Colorectal adenocarcinoma 14.68 13.38 10 117626 327 42503372
Blood creatine phosphokinase increased 14.66 13.38 76 117560 48262 42455437
Jaundice 14.65 13.38 153 117483 34436 42469263
Colon cancer recurrent 14.63 13.38 7 117629 114 42503585
Pelvic sepsis 14.60 13.38 4 117632 10 42503689
Rectal obstruction 14.60 13.38 4 117632 10 42503689
Diffuse large B-cell lymphoma 14.59 13.38 4 117632 9450 42494249
Cheilitis 14.59 13.38 26 117610 2582 42501117
Accidental exposure to product 14.59 13.38 21 117615 20372 42483327
Secondary adrenocortical insufficiency 14.51 13.38 23 117613 2076 42501623
Anal ulcer 14.46 13.38 17 117619 1154 42502545
Ocular vascular disorder 14.44 13.38 8 117628 179 42503520
Hydronephrosis 14.44 13.38 68 117568 11797 42491902
Blood pressure decreased 14.37 13.38 98 117538 58234 42445465
Blood potassium increased 14.36 13.38 18 117618 18518 42485181
Cytokine storm 14.35 13.38 15 117621 893 42502806
Genital herpes zoster 14.33 13.38 4 117632 11 42503688
Malignant pleural effusion 14.32 13.38 22 117614 1933 42501766
Temperature intolerance 14.31 13.38 37 117599 4751 42498948
Red cell distribution width increased 14.25 13.38 47 117589 6917 42496782
Haemorrhoidal haemorrhage 14.24 13.38 34 117602 4154 42499545
Syncope 14.22 13.38 191 117445 99215 42404484
Intracranial hypotension 14.21 13.38 11 117625 440 42503259
Eye pain 14.20 13.38 88 117548 16942 42486757
Impaired quality of life 14.17 13.38 11 117625 14166 42489533
Presyncope 14.17 13.38 25 117611 22362 42481337
Intestinal ulcer perforation 14.07 13.38 4 117632 12 42503687
Anaplastic meningioma 14.07 13.38 4 117632 12 42503687
Retroperitoneal abscess 14.06 13.38 10 117626 351 42503348
Pathogen resistance 14.05 13.38 7 117629 11443 42492256
Drug level decreased 14.01 13.38 5 117631 9972 42493727
Mean platelet volume decreased 13.97 13.38 13 117623 671 42503028
Skin exfoliation 13.96 13.38 63 117573 41490 42462209
IIIrd nerve paresis 13.95 13.38 7 117629 127 42503572
Therapeutic response unexpected 13.91 13.38 7 117629 11374 42492325
Swelling face 13.90 13.38 35 117601 27519 42476180
Blood triglycerides increased 13.89 13.38 14 117622 15882 42487817
Ventricular fibrillation 13.88 13.38 40 117596 30083 42473616
Blood creatinine decreased 13.88 13.38 31 117605 3627 42500072
Acquired tracheo-oesophageal fistula 13.86 13.38 7 117629 129 42503570
Retinal fibrosis 13.83 13.38 4 117632 13 42503686
COVID-19 pneumonia 13.81 13.38 24 117612 21589 42482110
Oesophageal irritation 13.75 13.38 6 117630 78 42503621
Neck pain 13.73 13.38 40 117596 29974 42473725
Intraocular lens implant 13.72 13.38 9 117627 276 42503423
Ophthalmological examination abnormal 13.71 13.38 5 117631 39 42503660
Blood pressure fluctuation 13.71 13.38 34 117602 26874 42476825
Herpes zoster 13.63 13.38 58 117578 38819 42464880
Acute cutaneous lupus erythematosus 13.62 13.38 6 117630 80 42503619
Treatment failure 13.61 13.38 109 117527 62515 42441184
Appendicitis noninfective 13.60 13.38 4 117632 14 42503685
Urinary retention 13.59 13.38 65 117571 42149 42461550
Visual field defect 13.58 13.38 37 117599 4901 42498798
Pulmonary congestion 13.57 13.38 14 117622 15716 42487983
Adverse event 13.57 13.38 28 117608 23612 42480087
Anaemia 13.50 13.38 922 116714 279356 42224343
Rectal haemorrhage 13.49 13.38 202 117434 49404 42454295
Adenocarcinoma metastatic 13.42 13.38 6 117630 83 42503616
Lower gastrointestinal perforation 13.39 13.38 4 117632 15 42503684

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 4859.64 12.70 3877 205536 240157 110139729
Proteinuria 2945.53 12.70 1462 207951 38556 110341330
Myelosuppression 1997.29 12.70 1557 207856 92783 110287103
Off label use 1635.96 12.70 6359 203054 1493826 108886060
Endophthalmitis 1504.47 12.70 571 208842 7616 110372270
Neuropathy peripheral 1361.58 12.70 1687 207726 177590 110202296
Gastrointestinal perforation 1316.11 12.70 505 208908 6951 110372935
Death 1239.79 12.70 3501 205912 695368 109684518
Palmar-plantar erythrodysaesthesia syndrome 1184.37 12.70 817 208596 40208 110339678
Hypertension 1181.01 12.70 2825 206588 507259 109872627
Neutrophil count decreased 959.57 12.70 1164 208249 119777 110260109
Malignant neoplasm progression 938.22 12.70 1389 208024 173178 110206708
Neutropenia 833.82 12.70 2045 207368 372575 110007311
Neoplasm progression 808.93 12.70 791 208622 63804 110316082
Metastases to liver 769.83 12.70 594 208819 34792 110345094
Intestinal perforation 769.48 12.70 485 208928 20459 110359427
Epistaxis 759.48 12.70 1078 208335 129294 110250592
Ascites 719.37 12.70 883 208530 91925 110287961
Metastases to lung 688.46 12.70 469 208944 22594 110357292
Joint swelling 640.70 12.70 53 209360 442792 109937094
Bone marrow failure 624.82 12.70 654 208759 57194 110322692
Anaemia 599.35 12.70 2331 207082 544755 109835131
Large intestine perforation 585.76 12.70 375 209038 16254 110363632
Diarrhoea 567.53 12.70 3890 205523 1135615 109244271
Thrombocytopenia 555.82 12.70 1685 207728 347200 110032686
Platelet count decreased 545.27 12.70 1289 208124 229154 110150732
Rheumatoid arthritis 494.98 12.70 16 209397 299597 110080289
Synovitis 478.27 12.70 8 209405 274084 110105802
Drug effective for unapproved indication 470.75 12.70 308 209105 13859 110366027
Peritonitis 466.60 12.70 430 208983 32177 110347709
Drug interaction 464.70 12.70 183 209230 500000 109879886
Pulmonary embolism 459.66 12.70 1155 208258 213319 110166567
Neurotoxicity 450.08 12.70 474 208939 41733 110338153
Mucosal inflammation 445.84 12.70 715 208698 95426 110284460
Interstitial lung disease 444.77 12.70 880 208533 138454 110241432
Suspected transmission of an infectious agent via product 437.96 12.70 145 209268 1255 110378631
Systemic lupus erythematosus 437.33 12.70 9 209404 254329 110125557
Arthropathy 431.05 12.70 29 209384 287493 110092393
Maternal exposure during pregnancy 416.10 12.70 15 209398 254868 110125018
Completed suicide 415.07 12.70 9 209404 242372 110137514
Contraindicated product administered 407.42 12.70 14 209399 248253 110131633
Macular oedema 406.77 12.70 218 209195 6748 110373138
Peripheral swelling 403.86 12.70 131 209282 403903 109975983
Therapy partial responder 382.38 12.70 409 209004 36652 110343234
Tumour haemorrhage 380.75 12.70 190 209223 5055 110374831
Oesophageal varices haemorrhage 364.49 12.70 181 209232 4764 110375122
Nephrotic syndrome 363.10 12.70 260 209153 13571 110366315
Intestinal obstruction 362.50 12.70 475 208938 52752 110327134
No adverse event 355.89 12.70 559 208854 73280 110306606
Posterior reversible encephalopathy syndrome 355.21 12.70 377 209036 33484 110346402
Musculoskeletal stiffness 353.10 12.70 54 209359 279768 110100118
Visual acuity reduced 349.60 12.70 365 209048 31808 110348078
Thrombotic microangiopathy 348.17 12.70 348 209065 28801 110351085
Psoriatic arthropathy 346.36 12.70 5 209408 196756 110183130
Metastases to central nervous system 344.26 12.70 310 209103 22507 110357379
Arthralgia 338.84 12.70 599 208814 779033 109600853
Condition aggravated 336.42 12.70 546 208867 734290 109645596
Swelling 334.91 12.70 123 209290 350918 110028968
White blood cell count decreased 333.58 12.70 1074 208339 228316 110151570
Small intestinal perforation 327.97 12.70 162 209251 4214 110375672
Peripheral sensory neuropathy 326.13 12.70 263 209150 16417 110363469
Glossodynia 319.64 12.70 27 209386 221977 110157909
Drug abuse 319.06 12.70 3 209410 177408 110202478
Subretinal fluid 318.21 12.70 113 209300 1231 110378655
Metastases to peritoneum 309.28 12.70 169 209244 5441 110374445
Helicobacter infection 306.58 12.70 8 209405 181869 110198017
Febrile neutropenia 304.97 12.70 1298 208115 315469 110064417
Wound dehiscence 304.05 12.70 189 209224 7773 110372113
Wheezing 302.77 12.70 58 209355 255172 110124714
Drug hypersensitivity 295.79 12.70 255 209158 453835 109926051
Tumour perforation 293.93 12.70 89 209324 556 110379330
Sinusitis 293.20 12.70 98 209315 296590 110083296
Drug intolerance 291.66 12.70 207 209206 406305 109973581
Abdominal discomfort 291.30 12.70 194 209219 393664 109986222
Varices oesophageal 290.11 12.70 177 209236 7038 110372848
Fibromyalgia 290.04 12.70 7 209406 170902 110208984
Tumour necrosis 288.79 12.70 124 209289 2312 110377574
Pain 287.97 12.70 892 208521 954063 109425823
Hepatic function abnormal 284.87 12.70 564 208849 88731 110291155
Pericarditis 284.04 12.70 39 209374 219075 110160811
Exposure during pregnancy 283.57 12.70 7 209406 167417 110212469
Metastases to bone 283.49 12.70 323 209090 31049 110348837
Decreased appetite 281.77 12.70 1700 207713 474146 109905740
Polyneuropathy 279.86 12.70 324 209089 31688 110348198
Detachment of retinal pigment epithelium 278.41 12.70 95 209318 910 110378976
Asthma 276.27 12.70 67 209346 250224 110129662
Irritable bowel syndrome 273.90 12.70 8 209405 164207 110215679
Bacterial endophthalmitis 272.58 12.70 73 209340 269 110379617
Hepatic enzyme increased 271.61 12.70 134 209279 320758 110059128
Hepatic failure 263.89 12.70 470 208943 68269 110311617
Portal hypertension 260.96 12.70 177 209236 8460 110371426
Overdose 259.18 12.70 62 209351 233732 110146154
Protein urine 258.96 12.70 101 209312 1455 110378431
Therapeutic product effect decreased 258.93 12.70 71 209342 244245 110135641
Blister 254.63 12.70 59 209354 227317 110152569
Wound 254.39 12.70 65 209348 234372 110145514
Metastases to meninges 251.37 12.70 143 209270 4985 110374901
Embolism 251.05 12.70 224 209189 16065 110363821
Urticaria 249.61 12.70 147 209266 318710 110061176
Weight increased 244.85 12.70 260 209153 419384 109960502
Product dose omission issue 244.01 12.70 154 209259 321628 110058258
Injury 240.85 12.70 27 209386 177238 110202648
Dehydration 237.70 12.70 1104 208309 278407 110101479
Ileus 237.33 12.70 292 209121 30437 110349449
Anastomotic leak 236.52 12.70 91 209322 1261 110378625
Blood cholesterol increased 234.57 12.70 35 209378 184750 110195136
Osteonecrosis of jaw 230.63 12.70 363 209050 47654 110332232
Injection site pain 229.81 12.70 32 209381 177890 110201996
Duodenal ulcer perforation 229.43 12.70 32 209381 177668 110202218
Retinal pigment epithelial tear 227.88 12.70 69 209344 431 110379455
Type 2 diabetes mellitus 226.29 12.70 33 209380 177199 110202687
Drug ineffective 226.24 12.70 1822 207591 1518718 108861168
Pneumothorax 222.02 12.70 303 209110 34982 110344904
Retinal haemorrhage 220.91 12.70 166 209247 9335 110370551
Lower respiratory tract infection 220.54 12.70 92 209321 243014 110136872
Glomerular vascular disorder 214.74 12.70 56 209357 181 110379705
Pruritus 213.72 12.70 492 208921 581068 109798818
Retinal oedema 213.44 12.70 89 209324 1538 110378348
Age-related macular degeneration 212.27 12.70 77 209336 896 110378990
Vitreous floaters 211.07 12.70 159 209254 8975 110370911
Nasopharyngitis 210.91 12.70 262 209151 394099 109985787
Small intestinal obstruction 209.34 12.70 281 209132 31932 110347954
Folliculitis 207.71 12.70 34 209379 167619 110212267
Mobility decreased 205.66 12.70 96 209317 237326 110142560
Dizziness 203.24 12.70 662 208751 697531 109682355
Leukopenia 202.14 12.70 681 208732 148110 110231776
Skin toxicity 201.65 12.70 172 209241 11611 110368275
Deep vein thrombosis 199.62 12.70 651 208762 139236 110240650
Portal vein thrombosis 197.58 12.70 138 209275 6920 110372966
Protein urine present 197.28 12.70 168 209245 11316 110368570
Rectal perforation 196.54 12.70 74 209339 963 110378923
Haematotoxicity 195.48 12.70 220 209193 20862 110359024
Depression 193.70 12.70 189 209224 317146 110062740
Osteoarthritis 193.61 12.70 53 209360 182570 110197316
Hypothyroidism 191.16 12.70 425 208988 72474 110307412
Discomfort 184.14 12.70 88 209325 214619 110165267
Bursitis 183.71 12.70 17 209396 129901 110249985
Joint range of motion decreased 183.34 12.70 12 209401 121820 110258066
Intentional product misuse 181.15 12.70 20 209393 132884 110247002
Insomnia 180.07 12.70 252 209161 360338 110019548
Migraine 176.10 12.70 53 209360 171599 110208287
Gastrointestinal toxicity 175.17 12.70 155 209258 10993 110368893
Vitreous haemorrhage 174.72 12.70 109 209304 4511 110375375
Hospitalisation 171.89 12.70 31 209382 142462 110237424
Treatment failure 171.64 12.70 163 209250 277071 110102815
Lip dry 170.17 12.70 4 209409 100079 110279807
Facet joint syndrome 168.09 12.70 3 209410 96825 110283061
Abdominal pain 166.29 12.70 1591 207822 511398 109868488
Pseudocirrhosis 164.60 12.70 63 209350 860 110379026
Nausea 160.01 12.70 3251 206162 1232439 109147447
Loss of personal independence in daily activities 158.15 12.70 44 209369 149976 110229910
Ovarian cancer recurrent 157.61 12.70 56 209357 611 110379275
Dermatitis acneiform 156.10 12.70 154 209259 12541 110367345
Suicide attempt 153.20 12.70 11 209402 103383 110276503
Fall 153.05 12.70 606 208807 602876 109777010
Sleep disorder 151.99 12.70 94 209319 198550 110181336
Pain in extremity 151.41 12.70 448 208965 486670 109893216
Hypertensive crisis 151.38 12.70 208 209205 24164 110355722
Gastric perforation 151.27 12.70 102 209311 4827 110375059
Metastasis 150.38 12.70 125 209288 8142 110371744
Hydronephrosis 149.40 12.70 190 209223 20475 110359411
Psoriasis 147.69 12.70 41 209372 139952 110239934
Prescribed overdose 147.01 12.70 4 209409 87577 110292309
Toxicity to various agents 145.74 12.70 447 208966 480108 109899778
Anxiety 145.16 12.70 270 209143 344808 110035078
Injection site erythema 142.52 12.70 9 209404 94167 110285719
Muscle spasms 141.23 12.70 192 209221 277965 110101921
Pleural effusion 140.84 12.70 688 208725 177021 110202865
Duodenal perforation 140.52 12.70 79 209334 2691 110377195
Hepatic atrophy 140.04 12.70 47 209366 426 110379460
Disseminated intravascular coagulation 137.98 12.70 266 209147 41020 110338866
Subileus 137.65 12.70 107 209306 6330 110373556
Arthritis 137.21 12.70 73 209340 167513 110212373
Necrotising fasciitis 134.40 12.70 113 209300 7478 110372408
Suicidal ideation 133.59 12.70 12 209401 93925 110285961
Cholangitis 132.27 12.70 159 209254 16176 110363710
Contusion 131.12 12.70 149 209264 233212 110146674
Red blood cell sedimentation rate increased 129.87 12.70 4 209409 78298 110301588
Vomiting 129.44 12.70 2431 206982 908244 109471642
Eye inflammation 129.35 12.70 120 209293 9051 110370835
Stoma site haemorrhage 128.77 12.70 71 209342 2327 110377559
Carcinoembryonic antigen increased 128.42 12.70 75 209338 2749 110377137
Feeling abnormal 128.19 12.70 93 209320 180618 110199268
Lower limb fracture 128.14 12.70 3 209410 75345 110304541
Neoplasm 128.05 12.70 130 209283 10957 110368929
Adrenal insufficiency 127.10 12.70 261 209152 42129 110337757
Metastases to lymph nodes 126.14 12.70 149 209264 14883 110365003
Nasal septum perforation 126.13 12.70 52 209361 872 110379014
Road traffic accident 126.04 12.70 25 209388 107373 110272513
Sciatica 125.67 12.70 14 209399 92385 110287501
Haemorrhage 125.66 12.70 466 208947 106226 110273660
Aortic dissection 125.51 12.70 91 209322 4842 110375044
Vitritis 124.73 12.70 72 209341 2581 110377305
Varicose vein ruptured 124.56 12.70 34 209379 137 110379749
Urogenital fistula 123.02 12.70 42 209371 403 110379483
Obesity 121.82 12.70 32 209381 113319 110266567
Tumour rupture 121.12 12.70 46 209367 614 110379272
Immune thrombocytopenia 120.62 12.70 179 209234 22315 110357571
Electrocardiogram QT prolonged 120.50 12.70 29 209384 108931 110270955
Constipation 120.46 12.70 1119 208294 356667 110023219
Colorectal cancer metastatic 119.60 12.70 59 209354 1530 110378356
Cystoid macular oedema 118.53 12.70 71 209342 2729 110377157
Night sweats 116.26 12.70 54 209359 133929 110245957
Drug reaction with eosinophilia and systemic symptoms 115.37 12.70 11 209402 82084 110297802
Osteoporosis 114.11 12.70 15 209398 87137 110292749
Photopsia 113.12 12.70 94 209319 6120 110373766
Eye haemorrhage 112.81 12.70 125 209288 11649 110368237
Enteritis 112.28 12.70 159 209254 18997 110360889
Retinal detachment 111.84 12.70 121 209292 10979 110368907
Product use issue 111.68 12.70 267 209146 311428 110068458
Product use in unapproved indication 111.58 12.70 452 208961 446925 109932961
Acute myeloid leukaemia 109.98 12.70 231 209182 37879 110342007
Dysphonia 109.75 12.70 355 209058 75574 110304312
Peripheral venous disease 108.90 12.70 15 209398 84102 110295784
Immune-mediated hepatitis 108.83 12.70 95 209318 6616 110373270
Suture rupture 107.18 12.70 43 209370 670 110379216
Perforation 106.68 12.70 57 209356 1753 110378133
Radiation necrosis 106.29 12.70 45 209368 809 110379077
Enterocolitis 106.25 12.70 154 209259 18795 110361091
Large intestinal obstruction 106.11 12.70 75 209338 3833 110376053
Colitis 105.88 12.70 429 208984 101894 110277992
Fistula 104.86 12.70 137 209276 15162 110364724
Stomal varices 104.31 12.70 29 209384 127 110379759
Influenza 102.79 12.70 101 209312 169000 110210886
Adverse event 102.19 12.70 39 209374 108770 110271116
Eastern Cooperative Oncology Group performance status worsened 102.19 12.70 66 209347 2903 110376983
Grip strength decreased 102.14 12.70 15 209398 80159 110299727
Sedation 101.57 12.70 8 209405 69675 110310211
Incorrect dose administered 100.98 12.70 35 209378 103606 110276280
Cerebral infarction 99.40 12.70 268 209145 51570 110328316
COVID-19 99.29 12.70 196 209217 244864 110135022
Pneumonitis 99.26 12.70 345 209068 76186 110303700
Malignant ascites 99.17 12.70 50 209363 1360 110378526
Enterocutaneous fistula 98.58 12.70 59 209354 2264 110377622
Headache 98.43 12.70 1133 208280 881244 109498642
Memory impairment 97.87 12.70 138 209275 196806 110183080
Venous thrombosis 96.90 12.70 99 209314 8406 110371480
Prescribed underdose 96.36 12.70 7 209406 65167 110314719
Pyrexia 95.77 12.70 2300 207113 895965 109483921
Paronychia 94.91 12.70 111 209302 10970 110368916
Myelodysplastic syndrome 94.30 12.70 215 209198 37269 110342617
Haemoptysis 93.70 12.70 323 209090 71031 110308855
Inflammation 93.47 12.70 138 209275 193100 110186786
Ovarian cancer metastatic 92.90 12.70 40 209373 751 110379135
Medication error 92.14 12.70 42 209371 105324 110274562
Asthenia 90.82 12.70 1819 207594 687180 109692706
Ileal perforation 90.79 12.70 47 209366 1353 110378533
Injection site reaction 90.43 12.70 28 209385 89042 110290844
Cerebral ischaemia 90.22 12.70 113 209300 11991 110367895
Blindness 89.76 12.70 207 209206 36152 110343734
Bronchitis 89.57 12.70 99 209314 156933 110222953
Hepatic encephalopathy 89.50 12.70 178 209235 28078 110351808
Ear infection 89.24 12.70 8 209405 62724 110317162
Renal-limited thrombotic microangiopathy 89.18 12.70 35 209378 513 110379373
Suspected counterfeit product 88.92 12.70 39 209374 767 110379119
Anastomotic complication 88.92 12.70 36 209377 575 110379311
Macular hole 88.84 12.70 42 209371 989 110378897
Abdominal abscess 88.61 12.70 96 209317 8723 110371163
Lymphocyte count decreased 88.55 12.70 274 209139 56969 110322917
Oesophagobronchial fistula 88.20 12.70 29 209384 245 110379641
Gait inability 88.14 12.70 77 209336 136299 110243587
Hypercholesterolaemia 87.94 12.70 31 209382 90806 110289080
Granulocyte count decreased 87.03 12.70 67 209346 3907 110375979
Metastatic neoplasm 87.02 12.70 79 209334 5794 110374092
Autoimmune disorder 86.38 12.70 11 209402 65472 110314414
Venous thrombosis limb 86.32 12.70 75 209338 5190 110374696
Osteonecrosis 85.40 12.70 194 209219 33547 110346339
Increased insulin requirement 84.75 12.70 27 209386 204 110379682
Infusion related reaction 84.16 12.70 403 209010 380759 109999127
Fistula of small intestine 84.15 12.70 41 209372 1034 110378852
Carbohydrate antigen 125 increased 83.70 12.70 55 209358 2492 110377394
Failure to anastomose 83.52 12.70 27 209386 215 110379671
Hyperammonaemia 83.49 12.70 116 209297 13616 110366270
Fluid retention 83.39 12.70 37 209376 94270 110285616
Ciliary hyperaemia 82.98 12.70 21 209392 58 110379828
Pulmonary fibrosis 82.71 12.70 45 209368 101997 110277889
Immune-mediated enterocolitis 82.24 12.70 99 209314 10086 110369800
Adverse drug reaction 82.05 12.70 49 209364 105510 110274376
Myocarditis 81.92 12.70 178 209235 29877 110350009
Gastrooesophageal reflux disease 81.82 12.70 134 209279 179842 110200044
Rash 81.74 12.70 1080 208333 819884 109560002
Azotaemia 81.38 12.70 98 209315 9987 110369899
Lactic acidosis 81.14 12.70 37 209376 92774 110287112
Wrong technique in product usage process 80.88 12.70 32 209381 87316 110292570
Blepharospasm 80.78 12.70 6 209407 54845 110325041
Blood bilirubin increased 80.57 12.70 321 209092 75651 110304235
Pregnancy 79.98 12.70 4 209409 51063 110328823
Performance status decreased 79.93 12.70 83 209330 7183 110372703
Treatment noncompliance 79.59 12.70 20 209393 72970 110306916
Tumour marker increased 78.80 12.70 70 209343 4990 110374896
Foot deformity 78.56 12.70 3 209410 48477 110331409
Dry mouth 78.36 12.70 163 209250 199785 110180101
Bradycardia 78.24 12.70 108 209305 155409 110224477
Rhabdomyolysis 77.79 12.70 68 209345 120333 110259553
Anastomotic fistula 77.75 12.70 23 209390 131 110379755
Injection site swelling 77.71 12.70 12 209401 61778 110318108
Injection site pruritus 77.25 12.70 5 209408 51253 110328633
Bleeding varicose vein 77.04 12.70 34 209379 679 110379207
Frequent bowel movements 77.00 12.70 20 209393 71370 110308516
Macular fibrosis 76.54 12.70 34 209379 690 110379196
Tracheal fistula 76.37 12.70 25 209388 208 110379678
Anal fistula 76.13 12.70 87 209326 8386 110371500
Joint stiffness 76.13 12.70 17 209396 67226 110312660
Hypopyon 75.58 12.70 42 209371 1398 110378488
Female genital tract fistula 75.35 12.70 122 209291 16397 110363489
Plasma cell myeloma 75.22 12.70 14 209399 62922 110316964
Hypoalbuminaemia 74.90 12.70 168 209245 28806 110351080
Exostosis 73.94 12.70 3 209410 45953 110333933
Somnolence 73.18 12.70 302 209111 297147 110082739
Therapeutic product effect incomplete 72.98 12.70 201 209212 223604 110156282
Accidental overdose 72.69 12.70 7 209406 51827 110328059
Retinal disorder 72.62 12.70 49 209364 2321 110377565
Malignant pleural effusion 72.61 12.70 61 209352 4032 110375854
Stress 72.40 12.70 56 209357 105292 110274594
Drug dependence 72.18 12.70 6 209407 50014 110329872
Nail toxicity 71.87 12.70 28 209385 402 110379484
Inappropriate schedule of product administration 71.67 12.70 176 209237 203461 110176425
Gastrointestinal anastomotic leak 71.52 12.70 33 209380 734 110379152
Chronic obstructive pulmonary disease 71.31 12.70 61 209352 109097 110270789
Eczema 71.14 12.70 24 209389 72269 110307617
Psychotic disorder 71.11 12.70 7 209406 50930 110328956
Arteriospasm coronary 71.11 12.70 87 209326 9013 110370873
Intracranial tumour haemorrhage 70.52 12.70 31 209382 613 110379273
Colon cancer metastatic 70.24 12.70 49 209364 2452 110377434
Hip arthroplasty 69.82 12.70 11 209402 55802 110324084
Confusional state 68.97 12.70 562 208851 468118 109911768
Metastases to pleura 68.89 12.70 45 209368 2018 110377868
Tremor 68.68 12.70 178 209235 202054 110177832
Lymphangiosis carcinomatosa 68.24 12.70 48 209365 2434 110377452
Liver carcinoma ruptured 67.85 12.70 25 209388 305 110379581
Gait disturbance 67.48 12.70 284 209129 277924 110101962
Vitreous detachment 67.44 12.70 49 209364 2616 110377270
Pneumatosis intestinalis 67.39 12.70 82 209331 8447 110371439
Hallucination 67.10 12.70 56 209357 101376 110278510
Laryngeal necrosis 66.82 12.70 16 209397 32 110379854
Hypomagnesaemia 66.37 12.70 258 209155 60112 110319774
Acute abdomen 65.71 12.70 53 209360 3308 110376578
Cataract nuclear 65.68 12.70 38 209375 1368 110378518
Leukoencephalopathy 65.61 12.70 84 209329 9111 110370775
C-reactive protein increased 65.04 12.70 204 209209 217715 110162171
Back injury 64.91 12.70 7 209406 47392 110332494
Microangiopathy 64.85 12.70 50 209363 2922 110376964
Tumour thrombosis 64.18 12.70 24 209389 306 110379580
Hypokalaemia 64.04 12.70 576 208837 181872 110198014
Palpitations 63.90 12.70 128 209285 159084 110220802
Acquired gene mutation 63.76 12.70 48 209365 2706 110377180
Neck pain 63.46 12.70 84 209329 123046 110256840
Erythema multiforme 63.36 12.70 130 209283 20967 110358919
Hyperbilirubinaemia 63.31 12.70 163 209250 30508 110349378
Drug level increased 62.98 12.70 8 209405 47711 110332175
Nasal congestion 62.89 12.70 56 209357 98226 110281660
General physical health deterioration 62.83 12.70 1143 208270 424152 109955734
Retinal vascular disorder 62.64 12.70 25 209388 384 110379502
Anterior chamber cell 62.42 12.70 35 209378 1186 110378700
Upper respiratory tract infection 62.32 12.70 95 209318 131233 110248653
Swelling face 62.27 12.70 50 209363 92271 110287615
Anterior chamber inflammation 62.00 12.70 30 209383 745 110379141
Amnesia 61.72 12.70 65 209348 105343 110274543
Choroidal neovascularisation 61.51 12.70 27 209386 532 110379354
Nightmare 61.00 12.70 3 209410 38860 110341026
Underdose 60.98 12.70 22 209391 63532 110316354
Malignant glioma 60.87 12.70 17 209396 76 110379810
Acute coronary syndrome 60.85 12.70 135 209278 22977 110356909
Angioedema 60.81 12.70 58 209355 98442 110281444
Encephalitis 60.05 12.70 119 209294 18720 110361166
Pulmonary haemorrhage 59.92 12.70 110 209303 16346 110363540
Retinal degeneration 59.73 12.70 38 209375 1628 110378258
Hepatic lesion 59.68 12.70 77 209336 8416 110371470
X-ray abnormal 59.65 12.70 3 209410 38114 110341772
Adrenocorticotropic hormone deficiency 59.53 12.70 42 209371 2140 110377746
Aggression 59.41 12.70 19 209394 59191 110320695
Thrombophlebitis migrans 59.03 12.70 29 209384 745 110379141
Pelvic abscess 58.80 12.70 45 209368 2601 110377285
Retinal artery occlusion 58.77 12.70 55 209358 4194 110375692
Perirectal abscess 58.64 12.70 42 209371 2192 110377694
Gene mutation 58.56 12.70 50 209363 3379 110376507
Non-infectious endophthalmitis 58.22 12.70 25 209388 466 110379420
Vitreous opacities 58.10 12.70 30 209383 859 110379027
Product prescribing error 58.06 12.70 13 209400 51318 110328568
Sleep apnoea syndrome 57.96 12.70 5 209408 40442 110339444
Gastrointestinal necrosis 57.68 12.70 67 209346 6573 110373313
Agitation 57.37 12.70 78 209335 112973 110266913
Glioblastoma 57.36 12.70 40 209373 2000 110377886
Hemiparesis 56.99 12.70 198 209215 43705 110336181
Microangiopathic haemolytic anaemia 56.76 12.70 39 209374 1904 110377982
Hypotension 56.58 12.70 677 208736 523172 109856714
Intraocular pressure increased 56.10 12.70 85 209328 10791 110369095
Lupus-like syndrome 55.93 12.70 6 209407 40786 110339100
Fatigue 55.90 12.70 2825 206588 1213133 109166753
Splenomegaly 55.62 12.70 135 209278 24363 110355523
Optical coherence tomography abnormal 55.60 12.70 18 209395 144 110379742
Intestinal metastasis 55.54 12.70 25 209388 524 110379362
Retinal exudates 55.50 12.70 33 209380 1251 110378635
Transmission of an infectious agent via product 55.31 12.70 19 209394 186 110379700
Incisional hernia 55.15 12.70 44 209369 2703 110377183
Retinal thickening 54.71 12.70 21 209392 289 110379597
Red cell distribution width increased 54.68 12.70 110 209303 17492 110362394
Gingival bleeding 54.64 12.70 118 209295 19721 110360165
Device related infection 54.61 12.70 182 209231 39337 110340549
Liver injury 54.50 12.70 128 209285 150285 110229601
Peritoneal disorder 54.34 12.70 28 209385 798 110379088
Hypersensitivity 54.26 12.70 496 208917 403502 109976384
Incorrect route of product administration 53.76 12.70 27 209386 64034 110315852
Drug withdrawal syndrome 53.73 12.70 5 209408 38049 110341837
Stomatitis 53.67 12.70 763 208650 269479 110110407
Illness 53.57 12.70 46 209367 82125 110297761
Product quality issue 53.22 12.70 41 209372 77258 110302628
Alpha 1 foetoprotein increased 53.16 12.70 28 209385 836 110379050
Peripheral motor neuropathy 52.92 12.70 51 209362 4035 110375851
Neoplasm recurrence 52.65 12.70 57 209356 5175 110374711
Oesophagitis 52.60 12.70 146 209267 28569 110351317
Dyskinesia 52.53 12.70 16 209397 51430 110328456
Liver function test increased 52.52 12.70 54 209359 88494 110291392
Macular ischaemia 52.31 12.70 19 209394 222 110379664
Rectal cancer metastatic 52.30 12.70 24 209389 527 110379359
Pantoea agglomerans infection 52.19 12.70 17 209396 139 110379747
Therapy interrupted 51.78 12.70 15 209398 49807 110330079
Venoocclusive liver disease 50.83 12.70 98 209315 15109 110364777
Cholecystitis acute 50.68 12.70 100 209313 15682 110364204
Mechanical ileus 50.50 12.70 31 209382 1246 110378640
Delirium 50.46 12.70 113 209300 134912 110244974
Ejection fraction decreased 50.17 12.70 181 209232 40699 110339187
Vascular pseudoaneurysm 49.98 12.70 50 209363 4140 110375746
Type 1 diabetes mellitus 49.96 12.70 73 209340 8974 110370912
Gastric varices 49.90 12.70 27 209386 852 110379034
Mucosal toxicity 49.55 12.70 25 209388 681 110379205
Adenocarcinoma metastatic 49.53 12.70 21 209392 379 110379507
Hypertensive encephalopathy 49.43 12.70 30 209383 1181 110378705
Enterovesical fistula 49.27 12.70 32 209381 1421 110378465
Superior vena cava syndrome 49.11 12.70 31 209382 1310 110378576
Proctalgia 48.92 12.70 89 209324 13133 110366753
Pulmonary artery thrombosis 48.80 12.70 33 209380 1569 110378317
Immune-mediated lung disease 48.58 12.70 55 209358 5248 110374638
Pneumoperitoneum 48.37 12.70 48 209365 3936 110375950
Metamorphopsia 48.23 12.70 33 209380 1600 110378286
Gastric varices haemorrhage 48.11 12.70 22 209391 479 110379407
Coma 47.95 12.70 94 209319 117775 110262111
Uveitis 47.55 12.70 118 209295 21592 110358294
Muscle spasticity 47.45 12.70 6 209407 35909 110343977
Drug resistance 47.33 12.70 222 209191 56152 110323734
Tumour ulceration 47.18 12.70 19 209394 299 110379587
Mean cell volume increased 47.14 12.70 68 209345 8262 110371624
Infectious pleural effusion 46.99 12.70 52 209361 4839 110375047
Irritability 46.82 12.70 16 209397 47793 110332093
Bronchial fistula 46.68 12.70 18 209395 251 110379635
Basal cell carcinoma 46.37 12.70 14 209399 45256 110334630
Gallbladder rupture 46.03 12.70 29 209384 1221 110378665
Dry throat 45.96 12.70 71 209342 9167 110370719
Embolism venous 45.85 12.70 52 209361 4971 110374915
Portal hypertensive gastropathy 45.84 12.70 34 209379 1874 110378012
Oedema 45.72 12.70 223 209190 209753 110170133
Hiccups 45.57 12.70 85 209328 12784 110367102
Joint injury 45.50 12.70 10 209403 39984 110339902
EGFR gene mutation 45.40 12.70 22 209391 548 110379338
Onychomycosis 45.14 12.70 9 209404 38522 110341364
Haemolytic anaemia 45.07 12.70 113 209300 20807 110359079
Device issue 45.07 12.70 6 209407 34529 110345357
Sepsis 44.94 12.70 870 208543 326476 110053410
Myoclonus 44.87 12.70 5 209408 32993 110346893
Acral peeling skin syndrome 44.85 12.70 12 209401 44 110379842
Burning sensation 44.81 12.70 39 209374 69173 110310713
Rash pruritic 44.58 12.70 73 209340 97996 110281890
Left ventricular dysfunction 44.57 12.70 121 209292 23372 110356514
Metastases to adrenals 44.07 12.70 31 209382 1572 110378314
Colitis ulcerative 43.86 12.70 49 209364 77314 110302572
Arterioenteric fistula 43.84 12.70 11 209402 29 110379857
Magnetic resonance imaging head abnormal 43.68 12.70 43 209370 3492 110376394
Bile duct stenosis 43.63 12.70 38 209375 2638 110377248
Hypoglycaemia 43.52 12.70 97 209316 116007 110263879
Lip swelling 43.05 12.70 21 209392 50646 110329240
Lung disorder 42.90 12.70 185 209228 179862 110200024
Neutropenic sepsis 42.84 12.70 142 209271 30604 110349282
Renal impairment 42.73 12.70 545 208868 187900 110191986
Disability 42.59 12.70 4 209409 30219 110349667
Vena cava thrombosis 42.24 12.70 42 209371 3452 110376434
Thyroiditis 42.18 12.70 57 209356 6516 110373370
Embolism arterial 42.15 12.70 32 209381 1827 110378059
Diverticular perforation 42.10 12.70 56 209357 6306 110373580
Pneumonia 42.07 12.70 1302 208111 875412 109504474
Adenocarcinoma 41.97 12.70 46 209367 4234 110375652
Myositis 41.84 12.70 142 209271 30974 110348912
Onychomadesis 41.83 12.70 17 209396 45646 110334240
Neovascular age-related macular degeneration 41.83 12.70 21 209392 566 110379320
Metastases to spine 41.62 12.70 51 209362 5292 110374594
Therapeutic response shortened 41.47 12.70 4 209409 29579 110350307
Cerebral haemorrhage 41.45 12.70 237 209176 64731 110315155
Retinitis 41.29 12.70 6 209407 32321 110347565
Retinal ischaemia 41.24 12.70 25 209388 982 110378904
Tumour fistulisation 41.22 12.70 14 209399 132 110379754
Cardiac failure congestive 41.18 12.70 147 209266 150853 110229033
Mean cell haemoglobin increased 41.16 12.70 52 209361 5565 110374321
Rectal ulcer 40.95 12.70 36 209377 2531 110377355
Throat tightness 40.86 12.70 148 209265 33341 110346545
Full blood count abnormal 40.84 12.70 28 209385 56024 110323862
Respiratory depression 40.73 12.70 6 209407 31995 110347891
Device related thrombosis 40.72 12.70 41 209372 3421 110376465
Biliary fistula 40.58 12.70 14 209399 139 110379747
Duodenal ulcer 40.58 12.70 104 209309 19410 110360476
Retinal neovascularisation 40.49 12.70 16 209397 239 110379647
Retinal vascular occlusion 40.49 12.70 21 209392 607 110379279
Blindness unilateral 40.25 12.70 69 209344 9717 110370169
Urinary occult blood 40.17 12.70 11 209402 45 110379841
Subretinal fibrosis 40.13 12.70 15 209398 191 110379695
Respiratory arrest 40.04 12.70 31 209382 58268 110321618
Abdominal infection 39.87 12.70 47 209366 4684 110375202
Angiogram retina abnormal 39.84 12.70 9 209404 12 110379874
Haemoglobin decreased 39.73 12.70 677 208736 248050 110131836
Dysaesthesia pharynx 39.49 12.70 16 209397 256 110379630
Cardiotoxicity 39.37 12.70 94 209319 16787 110363099
Pseudoendophthalmitis 39.22 12.70 12 209401 78 110379808
Dyspepsia 39.19 12.70 207 209206 190758 110189128
Retinal vein occlusion 39.18 12.70 43 209370 3964 110375922
Swollen tongue 39.09 12.70 34 209379 60328 110319558
Autoimmune haemolytic anaemia 38.94 12.70 71 209342 10496 110369390
Pharyngeal necrosis 38.58 12.70 12 209401 83 110379803
Cervix carcinoma recurrent 38.38 12.70 11 209402 55 110379831
Onycholysis 38.27 12.70 36 209377 2763 110377123
Cardiomyopathy 38.26 12.70 145 209268 33380 110346506
Abortion spontaneous 38.14 12.70 9 209404 34273 110345613
Poisoning 38.12 12.70 5 209408 29100 110350786
Mycotic endophthalmitis 37.91 12.70 18 209395 428 110379458
Bronchiectasis 37.90 12.70 11 209402 36482 110343404
Musculoskeletal pain 37.78 12.70 198 209215 182825 110197061
Haemoglobin 37.78 12.70 13 209400 128 110379758
Therapy responder 37.68 12.70 18 209395 434 110379452
Respiratory disorder 37.49 12.70 48 209365 71334 110308552
Ureteric compression 37.28 12.70 16 209397 298 110379588
Rectourethral fistula 37.15 12.70 8 209405 7 110379879
Tumour pseudoprogression 37.05 12.70 28 209385 1588 110378298
Injection site bruising 36.83 12.70 26 209387 51237 110328649
Respiratory tract congestion 36.58 12.70 7 209406 30850 110349036
Conjunctival hyperaemia 36.56 12.70 50 209363 5781 110374105
Thrombosis 36.56 12.70 340 209073 108322 110271564
Tumour invasion 36.23 12.70 19 209394 562 110379324
Metastases to abdominal wall 36.13 12.70 14 209399 198 110379688
Pulpitis dental 35.87 12.70 27 209386 1522 110378364
Urine protein/creatinine ratio increased 35.50 12.70 27 209386 1546 110378340
Fulminant type 1 diabetes mellitus 35.43 12.70 32 209381 2331 110377555
Colitis ischaemic 35.27 12.70 93 209320 17657 110362229
Ischaemic stroke 35.01 12.70 163 209250 41100 110338786
Cardiac failure 34.96 12.70 524 208889 187102 110192784
Urinary tract obstruction 34.92 12.70 46 209367 5131 110374755
Iridocyclitis 34.86 12.70 47 209366 5361 110374525
Eosinophilia 34.74 12.70 35 209378 57901 110321985
Therapy cessation 34.61 12.70 21 209392 44836 110335050
Non-small cell lung cancer metastatic 34.53 12.70 25 209388 1327 110378559
Thrombotic thrombocytopenic purpura 34.47 12.70 54 209359 7057 110372829
Vaginal fistula 34.43 12.70 16 209397 362 110379524
Diabetic retinopathy 34.42 12.70 38 209375 3526 110376360
Sneezing 34.41 12.70 9 209404 31975 110347911
Cyclitis 34.41 12.70 7 209406 3 110379883
Sudden death 34.29 12.70 113 209300 24282 110355604
Hypophagia 34.25 12.70 193 209220 52433 110327453
Colonic fistula 34.22 12.70 20 209393 734 110379152
Skin disorder 33.86 12.70 166 209247 42747 110337139
Lacrimation increased 33.80 12.70 132 209281 30818 110349068
Throat irritation 33.68 12.70 31 209382 53521 110326365
Metastases to ovary 33.56 12.70 16 209397 384 110379502
Abnormal behaviour 33.45 12.70 16 209397 39023 110340863
Disturbance in attention 33.28 12.70 41 209372 61954 110317932
Macular scar 33.24 12.70 11 209402 95 110379791
Emotional distress 33.22 12.70 22 209391 44825 110335061
Hepatic rupture 33.13 12.70 12 209401 139 110379747
Pelvic infection 33.04 12.70 16 209397 398 110379488
Cholecystitis 32.96 12.70 116 209297 25766 110354120
Metabolic acidosis 32.93 12.70 89 209324 99655 110280231
Hypopituitarism 32.74 12.70 41 209372 4349 110375537
Accidental exposure to product 32.59 12.70 28 209385 49980 110329906
Cholangitis sclerosing 32.56 12.70 37 209376 3545 110376341
Blood pressure increased 32.55 12.70 678 208735 257695 110122191
Eye discharge 32.48 12.70 59 209354 8695 110371191
Dystonia 32.47 12.70 5 209408 25800 110354086
Metastases to skin 32.26 12.70 30 209383 2269 110377617
Ill-defined disorder 32.20 12.70 170 209243 156683 110223203
Hyperthyroidism 32.12 12.70 125 209288 29136 110350750
Anal haemorrhage 31.87 12.70 43 209370 4909 110374977
Nervousness 31.73 12.70 15 209398 36836 110343050
Abdominal hernia 31.66 12.70 50 209363 6579 110373307
Stress cardiomyopathy 31.59 12.70 83 209330 15723 110364163
Haemobilia 31.44 12.70 18 209395 635 110379251
Nephrolithiasis 31.31 12.70 48 209365 66164 110313722
Gout 31.31 12.70 15 209398 36551 110343335
Extrapyramidal disorder 31.29 12.70 8 209405 28859 110351027
Skin ulcer 31.16 12.70 217 209196 63428 110316458
Chest pain 31.13 12.70 513 208900 375862 110004024
Bronchopleural fistula 31.10 12.70 20 209393 873 110379013
Hypophosphataemia 31.09 12.70 135 209278 33047 110346839
Cervix cancer metastatic 31.08 12.70 9 209404 47 110379839
Coronary artery disease 31.08 12.70 55 209358 71635 110308251
Jaundice 30.81 12.70 205 209208 59031 110320855
Miosis 30.74 12.70 3 209410 21980 110357906
Peritoneal neoplasm 30.72 12.70 11 209402 123 110379763
Dysaesthesia 30.46 12.70 50 209363 6797 110373089
Malaise 30.43 12.70 1005 208408 670814 109709072
Venous pressure jugular decreased 30.36 12.70 10 209403 85 110379801
Cystitis radiation 30.15 12.70 13 209400 245 110379641
Hyperhidrosis 30.13 12.70 219 209194 187079 110192807
Crying 29.99 12.70 6 209407 25622 110354264
Myalgia 29.84 12.70 273 209140 222108 110157778
Vitreoretinal traction syndrome 29.76 12.70 8 209405 30 110379856
Cardiogenic shock 29.66 12.70 39 209374 57299 110322587
Hypoferritinaemia 29.57 12.70 7 209406 13 110379873
Extravasation 29.56 12.70 41 209372 4804 110375082
Xeroderma 29.54 12.70 17 209396 606 110379280
Aspartate aminotransferase increased 29.53 12.70 446 208967 159490 110220396
Hypervolaemia 29.51 12.70 30 209383 49430 110330456
Unresponsive to stimuli 29.44 12.70 47 209366 63743 110316143
Ureteric fistula 29.36 12.70 8 209405 32 110379854
Post procedural bile leak 29.32 12.70 15 209398 421 110379465
Insulin autoimmune syndrome 29.31 12.70 18 209395 724 110379162
Blood pressure fluctuation 29.30 12.70 61 209352 74763 110305123
Hallucination, auditory 29.23 12.70 7 209406 26390 110353496
Rectal cancer recurrent 29.22 12.70 9 209404 60 110379826
Haematemesis 29.21 12.70 202 209211 58906 110320980
Anaemia of malignant disease 29.11 12.70 20 209393 976 110378910
Ventricular tachycardia 29.09 12.70 31 209382 49978 110329908
Visual field defect 29.00 12.70 61 209352 10011 110369875
Aortoenteric fistula 28.88 12.70 11 209402 148 110379738
Visual impairment 28.88 12.70 385 209028 134043 110245843
Rectal tenesmus 28.85 12.70 28 209385 2234 110377652
Shock haemorrhagic 28.78 12.70 115 209298 27132 110352754
Tumour hyperprogression 28.77 12.70 14 209399 352 110379534
Parkinsonism 28.61 12.70 4 209409 22183 110357703
Stomal hernia 28.40 12.70 16 209397 547 110379339
Labelled drug-drug interaction medication error 28.36 12.70 10 209403 29292 110350594
Melanoderma 28.26 12.70 15 209398 455 110379431
Immune-mediated encephalitis 28.13 12.70 21 209392 1169 110378717
Hypotony of eye 28.11 12.70 15 209398 460 110379426
Gastric disorder 28.08 12.70 14 209399 33343 110346543
Faecaluria 28.02 12.70 7 209406 18 110379868
Dry age-related macular degeneration 28.02 12.70 13 209400 293 110379593
Retinal scar 27.99 12.70 15 209398 464 110379422
Schizophrenia 27.99 12.70 4 209409 21822 110358064
Product substitution issue 27.84 12.70 5 209408 23056 110356830
Suture related complication 27.83 12.70 14 209399 379 110379507
Bladder perforation 27.79 12.70 14 209399 380 110379506
Tumour cavitation 27.48 12.70 9 209404 75 110379811
Product contamination microbial 27.42 12.70 20 209393 1074 110378812
Metastases to kidney 27.38 12.70 16 209397 587 110379299
Vitreal cells 27.32 12.70 11 209402 173 110379713
Infected lymphocele 27.31 12.70 12 209401 237 110379649
Oesophageal fistula 27.30 12.70 15 209398 488 110379398
Lymphopenia 27.26 12.70 149 209264 40021 110339865
Blood creatinine increased 27.12 12.70 492 208921 182397 110197489
Glomerulonephritis membranoproliferative 27.07 12.70 18 209395 832 110379054
Oesophageal haemorrhage 27.03 12.70 25 209388 1878 110378008
Gastrointestinal fistula 27.00 12.70 19 209394 964 110378922
Toxic anterior segment syndrome 26.95 12.70 33 209380 3421 110376465
Abdominal pain upper 26.88 12.70 482 208931 348629 110031257
Abdominal wound dehiscence 26.71 12.70 13 209400 327 110379559
Jejunal perforation 26.67 12.70 14 209399 415 110379471
Cardiac arrest 26.63 12.70 241 209172 196512 110183374
Immune-mediated myocarditis 26.62 12.70 33 209380 3465 110376421
Metastases to heart 26.58 12.70 14 209399 418 110379468
Pulmonary sarcoidosis 26.58 12.70 24 209389 1748 110378138
Hypertriglyceridaemia 26.55 12.70 79 209334 16075 110363811
Oligoastrocytoma 26.53 12.70 7 209406 24 110379862
Product dose omission in error 26.50 12.70 6 209407 23506 110356380
Rectal haemorrhage 26.49 12.70 345 209068 119488 110260398
Gastroenteritis viral 26.44 12.70 13 209400 31213 110348673
Encephalitis autoimmune 26.39 12.70 33 209380 3495 110376391
Post procedural fistula 26.28 12.70 14 209399 428 110379458
Transplant rejection 26.27 12.70 7 209406 24560 110355326
Retinal aneurysm 26.13 12.70 12 209401 264 110379622
Hypophysitis 26.08 12.70 41 209372 5374 110374512
Depressed mood 26.04 12.70 47 209366 60762 110319124
Hallucination, visual 26.02 12.70 22 209391 39583 110340303
Mesenteric vein thrombosis 26.02 12.70 25 209388 1970 110377916
Hyperammonaemic encephalopathy 25.97 12.70 41 209372 5393 110374493
Biliary tract disorder 25.96 12.70 24 209389 1802 110378084
Carbohydrate antigen 19-9 increased 25.90 12.70 15 209398 541 110379345
Loss of consciousness 25.90 12.70 242 209171 196064 110183822
Normal newborn 25.89 12.70 5 209408 21891 110357995
Blood glucose increased 25.87 12.70 146 209267 132350 110247536
Periodontitis 25.87 12.70 40 209373 5168 110374718
Blindness transient 25.83 12.70 43 209370 5913 110373973
Incorrect product administration duration 25.73 12.70 4 209409 20494 110359392
Corneal disorder 25.62 12.70 28 209385 2569 110377317
Procedural pain 25.60 12.70 18 209395 35547 110344339
Cutis laxa 25.58 12.70 10 209403 145 110379741
Febrile bone marrow aplasia 25.54 12.70 82 209331 17383 110362503
Diabetic foot 25.50 12.70 35 209378 4060 110375826
Incarcerated incisional hernia 25.49 12.70 7 209406 29 110379857
Appendicitis perforated 25.49 12.70 33 209380 3619 110376267
Seizure 25.47 12.70 573 208840 220612 110159274
Skin hyperpigmentation 25.42 12.70 53 209360 8643 110371243
Enterocolitis infectious 25.42 12.70 32 209381 3412 110376474
Haematocrit decreased 25.40 12.70 213 209200 65904 110313982
Atypical haemolytic uraemic syndrome 25.37 12.70 22 209391 1518 110378368
Chest discomfort 25.28 12.70 209 209204 173639 110206247
Vitreous adhesions 25.16 12.70 8 209405 60 110379826
Toxic epidermal necrolysis 25.06 12.70 43 209370 56684 110323202
Fixed bowel loop 25.06 12.70 6 209407 12 110379874
Progressive multifocal leukoencephalopathy 25.05 12.70 8 209405 24948 110354938
Gastropleural fistula 25.05 12.70 8 209405 61 110379825
Vitreous disorder 24.99 12.70 13 209400 378 110379508
Tracheo-oesophageal fistula 24.99 12.70 16 209397 693 110379193
Central nervous system mass 24.98 12.70 17 209396 817 110379069
Mental disorder 24.94 12.70 22 209391 38769 110341117
Ileus paralytic 24.87 12.70 63 209350 11674 110368212
Wall motion score index abnormal 24.85 12.70 17 209396 824 110379062
Liver abscess 24.80 12.70 49 209364 7690 110372196
Detachment of macular retinal pigment epithelium 24.74 12.70 6 209407 13 110379873
Arterial thrombosis 24.66 12.70 30 209383 3089 110376797
BRCA2 gene mutation 24.64 12.70 9 209404 107 110379779
Restlessness 24.53 12.70 43 209370 56216 110323670
Bronchopulmonary aspergillosis 24.44 12.70 13 209400 29850 110350036
Seasonal allergy 24.41 12.70 4 209409 19718 110360168
Abscess 24.41 12.70 110 209303 27359 110352527
Device malfunction 24.26 12.70 9 209404 25549 110354337
Anorectal disorder 24.23 12.70 28 209385 2731 110377155
Rash papular 24.18 12.70 11 209402 27628 110352258
Haematuria 24.16 12.70 252 209161 82753 110297133
Duodenal varices 24.14 12.70 6 209407 15 110379871
Meningitis 23.95 12.70 62 209351 11640 110368246
Drug use disorder 23.92 12.70 3 209410 18071 110361815
Radiation oesophagitis 23.91 12.70 17 209396 877 110379009
Pelvic fluid collection 23.91 12.70 18 209395 1015 110378871
Pulmonary fistula 23.84 12.70 9 209404 118 110379768
Skin burning sensation 23.75 12.70 6 209407 21819 110358067
Focal segmental glomerulosclerosis 23.69 12.70 34 209379 4111 110375775
Tachyphylaxis 23.69 12.70 13 209400 422 110379464
Breast cancer metastatic 23.68 12.70 60 209353 11121 110368765
Tooth erosion 23.66 12.70 13 209400 423 110379463
Localised infection 23.60 12.70 28 209385 43020 110336866
Walking aid user 23.52 12.70 9 209404 25066 110354820
Adenocarcinoma of colon 23.43 12.70 42 209371 6126 110373760
Limb injury 23.42 12.70 22 209391 37614 110342272
Gastrointestinal stoma complication 23.39 12.70 30 209383 3259 110376627
Retinal fibrosis 23.34 12.70 6 209407 18 110379868
Obstructive airways disorder 23.25 12.70 32 209381 46117 110333769
Right ventricular failure 23.23 12.70 10 209403 25944 110353942
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 23.23 12.70 8 209405 79 110379807
Delusion 23.17 12.70 8 209405 23747 110356139
Airway remodelling 23.11 12.70 17 209396 925 110378961
Dysgeusia 23.05 12.70 218 209195 69767 110310119
Second primary malignancy 23.03 12.70 81 209332 17987 110361899
Lymphadenopathy mediastinal 22.99 12.70 39 209374 5445 110374441
Ear pain 22.92 12.70 41 209372 53185 110326701
Device dislocation 22.88 12.70 16 209397 31688 110348198
Ulcerative keratitis 22.83 12.70 36 209377 4730 110375156
Wound evisceration 22.80 12.70 9 209404 134 110379752
Perforation bile duct 22.79 12.70 8 209405 84 110379802
Urethritis 22.78 12.70 15 209398 682 110379204
Radiation pneumonitis 22.76 12.70 35 209378 4501 110375385
Kidney infection 22.69 12.70 10 209403 25589 110354297
Choroiditis 22.52 12.70 21 209392 1594 110378292
Cardiac septal defect 22.50 12.70 17 209396 964 110378922
Duodenal obstruction 22.47 12.70 13 209400 468 110379418
Ankle fracture 22.45 12.70 5 209408 19814 110360072
Trichomegaly 22.45 12.70 9 209404 140 110379746
Aortic thrombosis 22.35 12.70 24 209389 2159 110377727
Nodular regenerative hyperplasia 22.34 12.70 21 209392 1610 110378276
Immune-mediated pancreatitis 22.26 12.70 15 209398 709 110379177
Pulmonary cavitation 22.25 12.70 24 209389 2170 110377716
Fingerprint loss 22.14 12.70 8 209405 92 110379794
Guillain-Barre syndrome 22.07 12.70 57 209356 10687 110369199
Peripheral sensorimotor neuropathy 22.04 12.70 32 209381 3911 110375975
Nail disorder 22.04 12.70 48 209365 57887 110321999
Laryngospasm 22.01 12.70 35 209378 4633 110375253
Diabetes mellitus 21.94 12.70 105 209308 99276 110280610
Aneurysm 21.88 12.70 34 209379 4412 110375474
Retinopathy proliferative 21.88 12.70 9 209404 150 110379736
Impaired quality of life 21.86 12.70 15 209398 30002 110349884
Colorectal cancer recurrent 21.76 12.70 8 209405 97 110379789
Metastases to oesophagus 21.73 12.70 7 209406 55 110379831
Pulmonary tumour thrombotic microangiopathy 21.72 12.70 9 209404 153 110379733
Mood swings 21.71 12.70 8 209405 22804 110357082
Malignant transformation 21.59 12.70 20 209393 1505 110378381
Immunodeficiency 21.57 12.70 25 209388 38813 110341073
Hypersplenism 21.49 12.70 15 209398 751 110379135
Torsade de pointes 21.38 12.70 8 209405 22592 110357294
Hypercreatinaemia 21.36 12.70 12 209401 408 110379478
Pharyngeal oedema 21.24 12.70 74 209339 16354 110363532
Restless legs syndrome 21.24 12.70 10 209403 24616 110355270
Eye pain 21.20 12.70 165 209248 49934 110329952
Ophthalmological examination abnormal 21.20 12.70 7 209406 60 110379826
Lung adenocarcinoma 21.08 12.70 52 209361 9479 110370407
Band sensation 21.08 12.70 17 209396 1061 110378825
Corneal striae 21.00 12.70 7 209406 62 110379824
Transfusion 20.98 12.70 11 209402 25461 110354425
Perihepatic abscess 20.95 12.70 9 209404 168 110379718
Limb discomfort 20.91 12.70 28 209385 40826 110339060
Wound complication 20.88 12.70 40 209373 6137 110373749
Macular detachment 20.75 12.70 10 209403 246 110379640
Hypermutation 20.72 12.70 8 209405 112 110379774
Productive cough 20.70 12.70 129 209284 114176 110265710
Gallbladder disorder 20.65 12.70 7 209406 21022 110358864
Cancer pain 20.65 12.70 42 209371 6730 110373156
Coordination abnormal 20.62 12.70 11 209402 25217 110354669
Metastases to gastrointestinal tract 20.61 12.70 9 209404 175 110379711
Pyelocaliectasis 20.52 12.70 17 209396 1102 110378784
Prothrombin level decreased 20.50 12.70 21 209392 1789 110378097
Immune-mediated hepatic disorder 20.48 12.70 33 209380 4417 110375469
Joint effusion 20.46 12.70 7 209406 20898 110358988
Ocular hypertension 20.42 12.70 24 209389 2384 110377502
Posterior capsule opacification 20.39 12.70 10 209403 256 110379630
Drug level decreased 20.38 12.70 5 209408 18543 110361343
Panic attack 20.37 12.70 15 209398 28925 110350961
Duodenal stenosis 20.37 12.70 16 209397 961 110378925
Haemolytic uraemic syndrome 20.31 12.70 35 209378 4950 110374936
Aneurysm ruptured 20.24 12.70 17 209396 1123 110378763
Anal abscess 20.17 12.70 58 209355 11580 110368306
Intestinal ischaemia 20.16 12.70 72 209341 16107 110363779
Atrophy of globe 20.16 12.70 7 209406 71 110379815
Retinal depigmentation 20.10 12.70 11 209402 355 110379531
Blood pressure systolic abnormal 20.07 12.70 11 209402 24839 110355047
Atopy 20.06 12.70 17 209396 1137 110378749
Akathisia 20.04 12.70 4 209409 17109 110362777
Haemorrhoidal haemorrhage 19.89 12.70 46 209367 8047 110371839
Eyelid ptosis 19.88 12.70 63 209350 13264 110366622
Rectal adenocarcinoma 19.86 12.70 20 209393 1669 110378217
Metastases to bone marrow 19.84 12.70 16 209397 998 110378888
Hiatus hernia 19.83 12.70 14 209399 27592 110352294
Secondary cerebellar degeneration 19.82 12.70 7 209406 75 110379811
Laryngitis 19.81 12.70 31 209382 42380 110337506
Cardiac murmur 19.75 12.70 11 209402 24617 110355269
Glycosylated haemoglobin increased 19.75 12.70 10 209403 23609 110356277
Cystic lung disease 19.74 12.70 11 209402 368 110379518
Tumour embolism 19.73 12.70 10 209403 275 110379611
Bladder tamponade 19.69 12.70 14 209399 722 110379164
Non-cirrhotic portal hypertension 19.61 12.70 14 209399 727 110379159
Hot flush 19.56 12.70 62 209351 65974 110313912
Heart rate increased 19.54 12.70 176 209237 143658 110236228
Rash erythematous 19.53 12.70 84 209329 81748 110298138
Soft tissue necrosis 19.51 12.70 17 209396 1181 110378705
Chemotherapy toxicity attenuation 19.45 12.70 5 209408 15 110379871
Intestinal fistula 19.43 12.70 20 209393 1713 110378173
Ovarian cancer 19.42 12.70 32 209381 4364 110375522
Optic neuropathy 19.36 12.70 33 209380 4625 110375261
Ocular discomfort 19.34 12.70 47 209366 8486 110371400
Tinnitus 19.25 12.70 55 209358 60485 110319401
Anaphylactic shock 19.24 12.70 165 209248 51381 110328505
Metastases to vagina 19.21 12.70 5 209408 16 110379870
Splenic artery thrombosis 19.18 12.70 7 209406 83 110379803
IIIrd nerve paralysis 19.16 12.70 18 209395 1379 110378507
Corneal epithelium defect 19.15 12.70 15 209398 897 110378989
Injection related reaction 19.14 12.70 19 209394 1559 110378327
Fear 19.12 12.70 10 209403 23183 110356703
Choroidal infarction 19.11 12.70 9 209404 210 110379676
Birdshot chorioretinopathy 19.10 12.70 7 209406 84 110379802
Prostate cancer 19.06 12.70 26 209387 37615 110342271
Anorectal infection 19.04 12.70 13 209400 628 110379258
Short-bowel syndrome 19.03 12.70 14 209399 762 110379124
Glomerulonephritis 18.99 12.70 33 209380 4697 110375189
Vitreous degeneration 18.99 12.70 6 209407 44 110379842
Appendicitis noninfective 18.98 12.70 5 209408 17 110379869
Thrombocytopenic purpura 18.97 12.70 26 209387 3013 110376873
Hyperlipidaemia 18.93 12.70 24 209389 35824 110344062
Proteus infection 18.88 12.70 25 209388 2803 110377083
Subclavian vein thrombosis 18.85 12.70 25 209388 2807 110377079
Retinal pigment epitheliopathy 18.78 12.70 12 209401 518 110379368
Tumour lysis syndrome 18.76 12.70 111 209302 30690 110349196
Retroperitoneal lymphadenopathy 18.74 12.70 18 209395 1418 110378468
Affect lability 18.66 12.70 6 209407 18631 110361255
Periodontal disease 18.57 12.70 21 209392 2001 110377885
Immune-mediated hypothyroidism 18.55 12.70 25 209388 2850 110377036
Exudative retinopathy 18.55 12.70 5 209408 19 110379867
Chemotherapy cardiotoxicity attenuation 18.55 12.70 5 209408 19 110379867
Aorto-oesophageal fistula 18.53 12.70 7 209406 92 110379794
Rales 18.51 12.70 12 209401 24727 110355159
Orthostatic hypotension 18.39 12.70 64 209349 66185 110313701
Photosensitivity reaction 18.36 12.70 13 209400 25576 110354310
Foot fracture 18.30 12.70 13 209400 25533 110354353
Carpal tunnel syndrome 18.27 12.70 10 209403 22600 110357286
Small intestinal haemorrhage 18.26 12.70 32 209381 4586 110375300
Keratic precipitates 18.25 12.70 12 209401 544 110379342
Sinus disorder 18.25 12.70 21 209392 32707 110347179
Biliary dilatation 18.23 12.70 28 209385 3597 110376289
Immune-mediated hypophysitis 18.19 12.70 15 209398 966 110378920
Thrombophlebitis 18.17 12.70 43 209370 7636 110372250
Anti-glomerular basement membrane disease 18.12 12.70 8 209405 160 110379726
Anal ulcer 18.12 12.70 20 209393 1856 110378030
Capillary leak syndrome 18.11 12.70 33 209380 4875 110375011
Polypoidal choroidal vasculopathy 18.08 12.70 9 209404 238 110379648
Immune-mediated dermatitis 18.07 12.70 22 209391 2268 110377618
Cough 18.04 12.70 703 208710 460938 109918948
Eosinophil count decreased 17.97 12.70 37 209376 5981 110373905
Retinoschisis 17.91 12.70 6 209407 54 110379832
Skin lesion 17.86 12.70 45 209368 51586 110328300
Drug dose omission by device 17.84 12.70 3 209410 14513 110365373
Abdominal adhesions 17.84 12.70 30 209383 4160 110375726
Therapy non-responder 17.83 12.70 201 209212 157106 110222780
Laryngeal leukoplakia 17.82 12.70 6 209407 55 110379831
Type II hypersensitivity 17.81 12.70 7 209406 103 110379783
Pelvic venous thrombosis 17.78 12.70 24 209389 2740 110377146
Cardiac disorder 17.78 12.70 79 209334 76201 110303685
Head injury 17.76 12.70 34 209379 42983 110336903
Neutropenic infection 17.65 12.70 26 209387 3219 110376667
Rash pustular 17.65 12.70 59 209354 12770 110367116
Visual acuity tests abnormal 17.63 12.70 8 209405 171 110379715
Protein induced by vitamin K absence or antagonist II increased 17.63 12.70 6 209407 57 110379829
Mydriasis 17.62 12.70 10 209403 22147 110357739
Lung abscess 17.62 12.70 33 209380 4979 110374907
Intravascular haemolysis 17.59 12.70 15 209398 1012 110378874
Maculopathy 17.55 12.70 25 209388 3002 110376884
Panniculitis 17.52 12.70 4 209409 15578 110364308
Dysstasia 17.51 12.70 22 209391 32964 110346922
Acquired tracheo-oesophageal fistula 17.50 12.70 8 209405 174 110379712
Hypoaesthesia 17.46 12.70 457 208956 313766 110066120
Serous cystadenocarcinoma ovary 17.43 12.70 4 209409 6 110379880
Glomerulonephropathy 17.36 12.70 10 209403 357 110379529
Skin cancer 17.33 12.70 6 209407 17778 110362108
Induration 17.32 12.70 22 209391 2367 110377519
Jugular vein thrombosis 17.32 12.70 34 209379 5311 110374575
Retroperitoneal abscess 17.32 12.70 12 209401 594 110379292
Skin haemorrhage 17.30 12.70 13 209400 24814 110355072
Anhedonia 17.26 12.70 4 209409 15424 110364462
Oedema peripheral 17.22 12.70 482 208931 328178 110051708
Peripheral paralysis 17.21 12.70 8 209405 181 110379705
Cachexia 17.18 12.70 59 209354 12946 110366940
Intestinal strangulation 17.18 12.70 6 209407 62 110379824
Hypokinesia 17.14 12.70 10 209403 21816 110358070
Skin striae 17.13 12.70 21 209392 2180 110377706
Change of bowel habit 17.09 12.70 24 209389 2845 110377041
Necrosis 17.08 12.70 54 209359 11352 110368534
Cerebrovascular accident 17.08 12.70 457 208956 180827 110199059
Disease recurrence 16.97 12.70 183 209230 60601 110319285
Aortitis 16.95 12.70 20 209393 1995 110377891
Influenza like illness 16.95 12.70 98 209315 88314 110291572
Hepatic mass 16.90 12.70 24 209389 2874 110377012
Hyperphosphataemia 16.90 12.70 5 209408 16376 110363510
Product dispensing error 16.84 12.70 5 209408 16340 110363546
Tongue geographic 16.84 12.70 7 209406 120 110379766
Choroidal haemorrhage 16.82 12.70 8 209405 191 110379695
Hyperpyrexia 16.77 12.70 43 209370 8026 110371860
Bone pain 16.77 12.70 193 209220 64940 110314946
Rectal abscess 16.73 12.70 23 209390 2673 110377213
Polychromasia 16.71 12.70 12 209401 629 110379257
Medulloblastoma recurrent 16.71 12.70 8 209405 194 110379692
Eye infection gonococcal 16.68 12.70 5 209408 30 110379856
K-ras gene mutation 16.68 12.70 6 209407 68 110379818
Malignant hypertension 16.64 12.70 18 209395 1633 110378253
Product administration error 16.63 12.70 28 209385 37189 110342697
Tractional retinal detachment 16.63 12.70 7 209406 124 110379762
Tendonitis 16.52 12.70 15 209398 26068 110353818
Diaphragmatic paralysis 16.47 12.70 16 209397 1278 110378608
Lymphocele 16.45 12.70 19 209394 1852 110378034
Cranial nerve disorder 16.44 12.70 16 209397 1281 110378605
Blood glucose decreased 16.36 12.70 19 209394 29469 110350417
Bone marrow disorder 16.36 12.70 29 209384 4194 110375692
Hydrocephalus 16.36 12.70 50 209363 10325 110369561
Herpes zoster 16.35 12.70 129 209284 108250 110271636
Gastroenteritis radiation 16.35 12.70 13 209400 795 110379091
Catheter site injury 16.32 12.70 9 209404 295 110379591
Pigmentation disorder 16.29 12.70 40 209373 7271 110372615
Fungal infection 16.27 12.70 46 209367 50760 110329126
Tardive dyskinesia 16.27 12.70 3 209410 13576 110366310
Heart rate decreased 16.26 12.70 91 209322 82665 110297221
Gastric ulcer 16.21 12.70 130 209283 39697 110340189
Cytomegalovirus infection 16.21 12.70 51 209362 54393 110325493
Colon cancer recurrent 16.18 12.70 7 209406 133 110379753
Intestinal prolapse 16.16 12.70 8 209405 209 110379677
Eczema impetiginous 16.15 12.70 5 209408 34 110379852
Diffuse large B-cell lymphoma 16.13 12.70 5 209408 15893 110363993
Cholangitis acute 16.11 12.70 19 209394 1894 110377992
Hepatic haemorrhage 16.06 12.70 16 209397 1318 110378568
Transformation to acute myeloid leukaemia 16.04 12.70 17 209396 1506 110378380
Biliary tract infection 16.00 12.70 18 209395 1706 110378180
Cardiac dysfunction 15.99 12.70 36 209377 6187 110373699
Anger 15.96 12.70 8 209405 18999 110360887
Head discomfort 15.95 12.70 8 209405 18992 110360894
Transaminases 15.94 12.70 6 209407 78 110379808
Mean platelet volume decreased 15.91 12.70 25 209388 3275 110376611
Rhinitis allergic 15.89 12.70 7 209406 17915 110361971
Neutrophil count abnormal 15.86 12.70 32 209381 5100 110374786
Malignant meningioma metastatic 15.81 12.70 3 209410 0 110379886
Choroidal rupture 15.81 12.70 3 209410 0 110379886
Instillation site complication 15.81 12.70 3 209410 0 110379886
Procedural haemorrhage 15.78 12.70 33 209380 5394 110374492
Subdural haematoma 15.77 12.70 28 209385 36426 110343460
Pharyngitis streptococcal 15.77 12.70 3 209410 13274 110366612
Product counterfeit 15.71 12.70 9 209404 318 110379568
White blood cell count increased 15.68 12.70 113 209300 96729 110283157
Poor quality sleep 15.68 12.70 18 209395 28059 110351827
Venous oxygen saturation increased 15.67 12.70 5 209408 38 110379848
Nasal crusting 15.62 12.70 13 209400 848 110379038
Diabetic retinal oedema 15.60 12.70 10 209403 434 110379452
Rash macular 15.60 12.70 31 209382 38655 110341231
Forced expiratory volume decreased 15.60 12.70 3 209410 13173 110366713
Mental impairment 15.59 12.70 12 209401 22627 110357259
Pseudocellulitis 15.58 12.70 10 209403 435 110379451
Iritis 15.57 12.70 30 209383 4622 110375264
Anaplastic meningioma 15.56 12.70 4 209409 12 110379874
Injection site haemorrhage 15.56 12.70 24 209389 33004 110346882
Iris neovascularisation 15.54 12.70 6 209407 84 110379802
Pathogen resistance 15.51 12.70 7 209406 17665 110362221
Ulcer haemorrhage 15.50 12.70 12 209401 22559 110357327
Adverse reaction 15.44 12.70 20 209393 29574 110350312
Metastases to eye 15.43 12.70 9 209404 329 110379557
Retinal cyst 15.41 12.70 7 209406 150 110379736
Metastases to abdominal cavity 15.40 12.70 13 209400 865 110379021
Uterine adhesions 15.34 12.70 5 209408 41 110379845
Alpha 1 foetoprotein decreased 15.32 12.70 4 209409 13 110379873
Metastases to bladder 15.31 12.70 9 209404 334 110379552
Atrioventricular block first degree 15.31 12.70 4 209409 14221 110365665
End stage renal disease 15.28 12.70 11 209402 21462 110358424
Skin discolouration 15.27 12.70 45 209368 49001 110330885
Nephritis 15.25 12.70 35 209378 6091 110373795
Biliary obstruction 15.24 12.70 33 209380 5525 110374361
Haemorrhagic tumour necrosis 15.23 12.70 5 209408 42 110379844
Toxic leukoencephalopathy 15.20 12.70 17 209396 1600 110378286
Vaginal cuff dehiscence 15.10 12.70 4 209409 14 110379872
Endothelial dysfunction 15.07 12.70 9 209404 344 110379542
Secondary hypertension 15.06 12.70 11 209402 592 110379294
Congestive cardiomyopathy 15.01 12.70 60 209353 14159 110365727
Aphonia 14.99 12.70 56 209357 12804 110367082
Dementia 14.94 12.70 23 209390 31650 110348236
Acquired amegakaryocytic thrombocytopenia 14.93 12.70 5 209408 45 110379841
Radiotherapy to mediastinum 14.88 12.70 4 209409 15 110379871
Periphlebitis 14.83 12.70 5 209408 46 110379840
Aphasia 14.82 12.70 174 209239 58823 110321063
Chondronecrosis 14.74 12.70 5 209408 47 110379839
Primary adrenal insufficiency 14.72 12.70 11 209402 613 110379273
Radiotherapy to lymph nodes 14.68 12.70 4 209409 16 110379870
Bone density decreased 14.65 12.70 6 209407 16036 110363850
Intervertebral disc degeneration 14.62 12.70 8 209405 18077 110361809
Clostridial infection 14.60 12.70 35 209378 6267 110373619
Palmar erythema 14.59 12.70 20 209393 2318 110377568
Blood albumin decreased 14.56 12.70 96 209317 27556 110352330
Intracranial hypotension 14.51 12.70 11 209402 627 110379259
Paraneoplastic neurological syndrome 14.50 12.70 7 209406 173 110379713
Upper limb fracture 14.48 12.70 11 209402 20877 110359009
Child-Pugh-Turcotte score increased 14.46 12.70 5 209408 50 110379836
Metastases to the mediastinum 14.44 12.70 12 209401 781 110379105
Corneal perforation 14.44 12.70 13 209400 943 110378943
Cortisol decreased 14.40 12.70 22 209391 2814 110377072
Enterobacter test positive 14.39 12.70 10 209403 497 110379389
Immune effector cell-associated neurotoxicity syndrome 14.38 12.70 5 209408 14777 110365109
Macular cyst 14.37 12.70 5 209408 51 110379835
Vaginal discharge 14.36 12.70 8 209405 17900 110361986
Cytopenia 14.34 12.70 102 209311 30014 110349872
Cholinergic syndrome 14.27 12.70 15 209398 1317 110378569
Nail pigmentation 14.24 12.70 9 209404 381 110379505
Hepatic pain 14.20 12.70 29 209384 4661 110375225
Tracheal haemorrhage 14.17 12.70 12 209401 802 110379084
Pyelonephritis 14.12 12.70 89 209324 25161 110354725
Stoma site pain 14.11 12.70 18 209395 1945 110377941
Anal fissure 14.09 12.70 46 209367 9835 110370051
Budd-Chiari syndrome 14.02 12.70 6 209407 111 110379775
Retinal tear 14.01 12.70 18 209395 1959 110377927
Adrenal disorder 13.98 12.70 20 209393 2412 110377474
Drug tolerance decreased 13.97 12.70 19 209394 27521 110352365
Blood alkaline phosphatase increased 13.95 12.70 200 209213 70735 110309151
Extra dose administered 13.91 12.70 3 209410 12156 110367730
Upper gastrointestinal perforation 13.80 12.70 5 209408 58 110379828
Inferior vena cava stenosis 13.77 12.70 6 209407 116 110379770
Amaurosis 13.75 12.70 16 209397 1573 110378313
Eye laser scar 13.74 12.70 3 209410 3 110379883
Superior vena cava stenosis 13.74 12.70 3 209410 3 110379883
Cytoreductive surgery 13.74 12.70 3 209410 3 110379883
Pelvic sepsis 13.74 12.70 3 209410 3 110379883
Gastrointestinal obstruction 13.73 12.70 19 209394 2221 110377665
Blood corticotrophin decreased 13.72 12.70 12 209401 838 110379048
Metastases to pelvis 13.69 12.70 12 209401 840 110379046
Tumour pain 13.65 12.70 22 209391 2945 110376941
Hepatic vein stenosis 13.65 12.70 5 209408 60 110379826
Charles Bonnet syndrome 13.65 12.70 5 209408 60 110379826
Anorectal varices haemorrhage 13.64 12.70 4 209409 22 110379864
Neurological decompensation 13.61 12.70 36 209377 6847 110373039
Peritumoural oedema 13.49 12.70 4 209409 23 110379863
Aortic stenosis 13.44 12.70 4 209409 13055 110366831
Infection 13.41 12.70 555 208858 361645 110018241
Vascular access complication 13.38 12.70 20 209393 2508 110377378
Amylase increased 13.35 12.70 53 209360 12466 110367420
Portal vein embolisation 13.35 12.70 4 209409 24 110379862
Sinus bradycardia 13.34 12.70 22 209391 29461 110350425
Vocal cord paresis 13.34 12.70 8 209405 308 110379578
Creatinine renal clearance decreased 13.28 12.70 13 209400 21802 110358084
Exposed bone in jaw 13.28 12.70 25 209388 3786 110376100
Gliomatosis cerebri 13.28 12.70 3 209410 4 110379882
Tumour exudation 13.28 12.70 3 209410 4 110379882
Vascular pseudoaneurysm ruptured 13.25 12.70 10 209403 566 110379320
Motor dysfunction 13.25 12.70 16 209397 24390 110355496
Tumour compression 13.20 12.70 7 209406 212 110379674
Hydrothorax 13.20 12.70 16 209397 1642 110378244
Product storage error 13.17 12.70 13 209400 21715 110358171
Gastrointestinal disorder 13.14 12.70 353 209060 241599 110138287
Thirst 13.14 12.70 13 209400 21694 110358192
Eating disorder 13.08 12.70 24 209389 30834 110349052
Incarcerated inguinal hernia 13.07 12.70 8 209405 320 110379566
Potentiating drug interaction 13.06 12.70 3 209410 11640 110368246
Procedural site reaction 13.00 12.70 9 209404 445 110379441
Splenorenal shunt 12.95 12.70 4 209409 27 110379859
Alanine aminotransferase increased 12.93 12.70 447 208966 183326 110196560
Blood pressure diastolic increased 12.92 12.70 70 209343 18737 110361149
Liver function test abnormal 12.91 12.70 77 209336 68873 110311013
Malignant melanoma 12.90 12.70 8 209405 16883 110363003
Neutrophilia 12.90 12.70 46 209367 10283 110369603
Glioblastoma multiforme 12.88 12.70 15 209398 1475 110378411
Pneumonia chlamydial 12.86 12.70 6 209407 137 110379749
IIIrd nerve paresis 12.85 12.70 7 209406 224 110379662
Pulmonary toxicity 12.84 12.70 67 209346 17679 110362207
Gastrointestinal stoma necrosis 12.82 12.70 4 209409 28 110379858
Epstein-Barr virus infection 12.82 12.70 10 209403 18728 110361158
Brain stem ischaemia 12.80 12.70 8 209405 332 110379554
Stoma site abscess 12.80 12.70 8 209405 332 110379554
Surgery 12.77 12.70 38 209375 41245 110338641
Dialysis 12.76 12.70 11 209402 19608 110360278
Middle insomnia 12.74 12.70 12 209401 20490 110359396
Faecaloma 12.72 12.70 59 209354 14849 110365037
Mood altered 12.71 12.70 13 209400 21362 110358524

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FG01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
VEGF/VEGFR (Vascular Endothelial Growth Factor / -Receptor) inhibitors
ATC S01LA08 SENSORY ORGANS
OPHTHALMOLOGICALS
OCULAR VASCULAR DISORDER AGENTS
Antineovascularisation agents
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D000970 Antineoplastic Agents
MeSH PA D006131 Growth Inhibitors
MeSH PA D006133 Growth Substances
MeSH PA D020533 Angiogenesis Inhibitors
FDA MoA N0000178291 Vascular Endothelial Growth Factor-directed Antibody Interactions
FDA MoA N0000193542 Vascular Endothelial Growth Factor Inhibitors
FDA EPC N0000193543 Vascular Endothelial Growth Factor Inhibitor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

L01FG VEGF/VEGFR (Vascular Endothelial Growth Factor / -Receptor) inhibitors 1 drug
ramucirumab
S01LA Antineovascularisation agents 7 drugs
afliberceptanecortavebrolucizumabfaricimabpegaptanibranibizumabverteporfin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Secondary malignant neoplasm of colon indication 94260004
Liver cell carcinoma indication 109841003 DOID:684
Malignant neoplasm of breast indication 254837009 DOID:1612
Malignant epithelial tumor of ovary indication 254849005
Carcinoma of cervix indication 285432005 DOID:2893
Malignant tumor of fallopian tube indication 363444001 DOID:1964
Malignant tumor of peritoneum indication 363492001
Glioblastoma multiforme indication 393563007
Nonsquamous nonsmall cell neoplasm of lung indication 440173001
Metastatic renal cell carcinoma indication 702392008
Non-small cell lung cancer with mutation in epidermal growth factor receptor indication 703228009
Malignant neoplasm of colon and/or rectum indication 781382000
Metastatic carcinoma to colon indication 1237484006
Age-related macular degeneration off-label use 267718000 DOID:10871
Pregnancy, function contraindication 289908002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vascular endothelial growth factor A Secreted ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D06409 KEGG_DRUG
4021437 VUID
N0000148845 NUI
4021437 VANDF
4038596 VANDF
CHEBI:749495 CHEBI
CHEMBL1201583 ChEMBL_ID
6771 IUPHAR_LIGAND_ID
DB00112 DRUGBANK_ID
2046138 RXNORM
18086 MMSL
267594 MMSL
33386 MMSL
49612 MMSL
d05214 MMSL
008586 NDDF
017340 NDDF
409405006 SNOMEDCT_US
409406007 SNOMEDCT_US
C0796392 UMLSCUI
D000068258 MESH_DESCRIPTOR_UI
8017 INN_ID
2S9ZZM9Q9V UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zirabev HUMAN PRESCRIPTION DRUG LABEL 1 0069-0315 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 28 sections
Zirabev HUMAN PRESCRIPTION DRUG LABEL 1 0069-0342 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 28 sections
Avastin HUMAN PRESCRIPTION DRUG LABEL 1 50242-060 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 28 sections
Avastin HUMAN PRESCRIPTION DRUG LABEL 1 50242-061 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 28 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-206 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 29 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-207 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 29 sections
ALYMSYS HUMAN PRESCRIPTION DRUG LABEL 1 70121-1754 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 24 sections
ALYMSYS HUMAN PRESCRIPTION DRUG LABEL 1 70121-1755 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 24 sections
Vegzelma HUMAN PRESCRIPTION DRUG LABEL 1 72606-011 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 29 sections
Vegzelma HUMAN PRESCRIPTION DRUG LABEL 1 72606-012 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 29 sections
JOBEVNE HUMAN PRESCRIPTION DRUG LABEL 1 83257-009 INJECTION 25 mg INTRAVASCULAR BLA 26 sections
JOBEVNE HUMAN PRESCRIPTION DRUG LABEL 1 83257-010 INJECTION 25 mg INTRAVASCULAR BLA 26 sections
ALYMSYS HUMAN PRESCRIPTION DRUG LABEL 1 85006-1754 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 24 sections
ALYMSYS HUMAN PRESCRIPTION DRUG LABEL 1 85006-1755 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 24 sections