lutropin alfa Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4929 152923-57-4

Description:

MoleculeDescription

Synonyms:

  • luteinising hormone
  • lutropin alfa
  • luveris
  • lutropin alfa for injection
  • lutropina alfa
  • r-hLH
  • human LH
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
75 U P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 8, 2004 FDA EMD SERONO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 670.69 68.43 94 357 3098 46682513
Ascites 69.77 68.43 22 429 36562 46649049

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC G03GA07 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
FDA CS M0009540 Gonadotropins
FDA EPC N0000175838 Gonadotropin

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lutropin-choriogonadotropic hormone receptor GPCR AGONIST IC50 10.90 IUPHAR DRUG LABEL

External reference:

IDSource
D04824 KEGG_DRUG
4021497 VUID
N0000148867 NUI
4019252 VANDF
4021497 VANDF
C0023607 UMLSCUI
CHEMBL1201697 ChEMBL_ID
CHEMBL1201419 ChEMBL_ID
DB14741 DRUGBANK_ID
DB00044 DRUGBANK_ID
7047 INN_ID
3JGY52XJNULL UNII
388084 RXNORM
18123 MMSL
52532 MMSL
d05029 MMSL
009355 NDDF
391621007 SNOMEDCT_US
415248001 SNOMEDCT_US
64182005 SNOMEDCT_US

Pharmaceutical products:

None