follitropin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 4928 146479-72-3

Description:

MoleculeDescription

Synonyms:

  • follitropin delta
  • follitropin alfa
  • follitropin beta
  • follitropin alfa/beta
  • follicle-stimulating hormone
  • urofollitropin
  • follitropin
  • human follicle stimulating hormone
  • FSH
A protein extract of human menopausal urine in which LUTEINIZING HORMONE has been partially or completely removed. Urofollitropin represents FOLLICLE STIMULATING HORMONE from the urine.
  • Molecular weight: 22668.79
  • Formula: C975H1493N267O305S26
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 5077.47
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
75 U P
75 U P
75 U P
12 mcg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 2, 1996 EMA N.V. Organon
Sept. 18, 1986 FDA SERONO
Jan. 23, 2006 PMDA SERONO JAPAN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 4852.28 47.98 706 3907 3308 63481101
Ascites 740.42 47.98 221 4392 40507 63443902
No adverse event 243.88 47.98 97 4516 41308 63443101
Abdominal distension 235.54 47.98 118 4495 86497 63397912
Ovarian enlargement 206.06 47.98 35 4578 459 63483950
Maternal exposure before pregnancy 167.10 47.98 48 4565 7555 63476854
Haemoperitoneum 151.44 47.98 36 4577 2705 63481704
Product quality issue 140.68 47.98 63 4550 35802 63448607
Pelvic fluid collection 136.50 47.98 27 4586 849 63483560
Ovarian haemorrhage 134.45 47.98 23 4590 315 63484094
Adnexal torsion 134.25 47.98 24 4589 430 63483979
Inappropriate schedule of product administration 126.53 47.98 84 4529 103881 63380528
Product packaging quantity issue 119.08 47.98 26 4587 1333 63483076
Poor quality device used 113.35 47.98 27 4586 2044 63482365
Abortion spontaneous 106.95 47.98 57 4556 47138 63437271
Progesterone increased 92.89 47.98 13 4600 39 63484370
Pleural effusion 91.42 47.98 66 4547 93144 63391265
Haemoconcentration 80.02 47.98 13 4600 127 63484282
Ovarian cyst ruptured 62.34 47.98 15 4598 1184 63483225
Incorrect dose administered 59.96 47.98 43 4570 59925 63424484
Ectopic pregnancy 59.93 47.98 17 4596 2550 63481859
Abdominal pain lower 58.08 47.98 31 4582 25647 63458762
Circumstance or information capable of leading to medication error 57.18 47.98 18 4595 3852 63480557
Abortion missed 56.97 47.98 15 4598 1704 63482705
Abortion 55.89 47.98 16 4597 2480 63481929
Abdominal pain 55.72 47.98 86 4527 293370 63191039
Premature ovulation 51.70 47.98 7 4606 15 63484394
Multiple pregnancy 51.61 47.98 8 4605 56 63484353
Oestradiol decreased 49.08 47.98 7 4606 25 63484384

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 4868.01 55.24 655 2864 2916 79737953
Ascites 682.15 55.24 213 3306 75349 79665520
Ovarian enlargement 233.84 55.24 35 3484 333 79740536
Abdominal distension 185.98 55.24 95 3424 119555 79621314
Pelvic fluid collection 151.78 55.24 27 3492 792 79740077
Adnexal torsion 143.06 55.24 23 3496 360 79740509
Ovarian haemorrhage 140.08 55.24 22 3497 294 79740575
Haemoperitoneum 137.25 55.24 33 3486 4310 79736559
Maternal exposure before pregnancy 111.67 55.24 28 3491 4345 79736524
Progesterone increased 99.63 55.24 13 3506 38 79740831
Pleural effusion 87.84 55.24 63 3456 145199 79595670
Haemoconcentration 75.04 55.24 12 3507 181 79740688
Ovarian cyst ruptured 67.19 55.24 14 3505 952 79739917
Abdominal pain lower 66.50 55.24 31 3488 31751 79709118
Abdominal pain 62.33 55.24 81 3438 389488 79351381
Poor quality device used 60.17 55.24 15 3504 2270 79738599
No adverse event 58.93 55.24 30 3489 37162 79703707
Abortion missed 57.75 55.24 13 3506 1270 79739599
Premature ovulation 56.22 55.24 7 3512 12 79740857
Product quality issue 55.59 55.24 28 3491 33912 79706957

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03GA04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
ATC G03GA05 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
ATC G03GA06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
ATC G03GA10 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
FDA CS M0009540 Gonadotropins
MeSH PA D006728 Hormones
FDA EPC N0000175838 Gonadotropin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ovulation induction indication 61285001




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Induction or superovulation Indication

🐶 Veterinary products

ProductApplicantIngredients
Super-Ov Therio Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Follicle-stimulating hormone receptor GPCR AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D06269 KEGG_DRUG
4019254 VUID
N0000147458 NUI
4019253 VANDF
4019254 VANDF
4021069 VANDF
4021070 VANDF
4024094 VANDF
CHEBI:81569 CHEBI
CHEMBL4297955 ChEMBL_ID
CHEMBL1201692 ChEMBL_ID
CHEMBL2108427 ChEMBL_ID
C000620228 MESH_SUPPLEMENTAL_RECORD_UI
C571801 MESH_SUPPLEMENTAL_RECORD_UI
C571802 MESH_SUPPLEMENTAL_RECORD_UI
DB00066 DRUGBANK_ID
DB00094 DRUGBANK_ID
134404 RXNORM
4760 MMSL
5657 MMSL
7863 MMSL
7864 MMSL
d00570 MMSL
d04043 MMSL
002102 NDDF
006654 NDDF
006941 NDDF
006978 NDDF
103028007 SNOMEDCT_US
109042006 SNOMEDCT_US
109044007 SNOMEDCT_US
126185008 SNOMEDCT_US
25217009 SNOMEDCT_US
325781003 SNOMEDCT_US
395862009 SNOMEDCT_US
395920003 SNOMEDCT_US
725743001 SNOMEDCT_US
763577005 SNOMEDCT_US
768662008 SNOMEDCT_US
C0733758 UMLSCUI
D005640 MESH_DESCRIPTOR_UI
D050477 MESH_DESCRIPTOR_UI
CHEMBL1201520 ChEMBL_ID
9503 INN_ID
9732 INN_ID
1919 INN_ID
7505 INN_ID
4798 INN_ID
62819 PUBCHEM_CID
1157 IUPHAR_LIGAND_ID
076WHW89TW UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0313 INJECTION, SOLUTION 350 [iU] SUBCUTANEOUS BLA 28 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0313 INJECTION, SOLUTION 350 [iU] SUBCUTANEOUS BLA 28 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0316 INJECTION, SOLUTION 650 [iU] SUBCUTANEOUS BLA 28 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0316 INJECTION, SOLUTION 650 [iU] SUBCUTANEOUS BLA 28 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0326 INJECTION, SOLUTION 975 [iU] SUBCUTANEOUS BLA 28 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0326 INJECTION, SOLUTION 975 [iU] SUBCUTANEOUS BLA 28 sections
Gonal-f RFF Redi-ject HUMAN PRESCRIPTION DRUG LABEL 1 44087-1115 INJECTION, SOLUTION 300 [iU] SUBCUTANEOUS BLA 28 sections
Gonal-f RFF Redi-ject HUMAN PRESCRIPTION DRUG LABEL 1 44087-1116 INJECTION, SOLUTION 450 [iU] SUBCUTANEOUS BLA 28 sections
Gonal-f RFF Redi-ject HUMAN PRESCRIPTION DRUG LABEL 1 44087-1117 INJECTION, SOLUTION 900 [iU] SUBCUTANEOUS BLA 28 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 78206-129 INJECTION, SOLUTION 300 [iU] SUBCUTANEOUS BLA 27 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 78206-130 INJECTION, SOLUTION 600 [iU] SUBCUTANEOUS BLA 27 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 78206-131 INJECTION, SOLUTION 900 [iU] SUBCUTANEOUS BLA 27 sections