follitropin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 4928 146479-72-3

Description:

MoleculeDescription

Synonyms:

  • follitropin delta
  • follitropin alfa
  • follitropin beta
  • follitropin alfa/beta
  • follicle-stimulating hormone
  • urofollitropin
  • follitropin
  • human follicle stimulating hormone
  • FSH
A protein extract of human menopausal urine in which LUTEINIZING HORMONE has been partially or completely removed. Urofollitropin represents FOLLICLE STIMULATING HORMONE from the urine.
  • Molecular weight: 22668.79
  • Formula: C975H1493N267O305S26
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 5077.47
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
75 U P
75 U P
75 U P
12 mcg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Jan. 23, 2006 PMDA SERONO JAPAN
Sept. 18, 1986 FDA SERONO
May 2, 1996 EMA N.V. Organon

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 6905.97 46.49 996 5031 4866 90617554
Ascites 903.05 46.49 262 5765 47478 90574942
Abdominal distension 455.01 46.49 205 5822 130396 90492024
Ovarian enlargement 236.58 46.49 40 5987 560 90621860
Ovarian haemorrhage 215.56 46.49 35 5992 376 90622044
No adverse event 208.72 46.49 98 5929 67884 90554536
Maternal exposure before pregnancy 199.92 46.49 59 5968 11154 90611266
Abdominal pain 179.00 46.49 172 5855 395549 90226871
Pelvic fluid collection 176.27 46.49 34 5993 1025 90621395
Haemoperitoneum 150.59 46.49 37 5990 3491 90618929
Adnexal torsion 145.59 46.49 26 6001 508 90621912
Abortion spontaneous 141.79 46.49 70 5957 53986 90568434
Pleural effusion 125.03 46.49 83 5944 111908 90510512
Product packaging quantity issue 117.09 46.49 26 6001 1576 90620844
Tension 114.57 46.49 30 5997 3652 90618768
Poor quality device used 112.98 46.49 27 6000 2266 90620154
Inappropriate schedule of product administration 105.45 46.49 84 5943 149849 90472571
Progesterone increased 100.54 46.49 14 6013 45 90622375
Product quality issue 98.80 46.49 63 5964 79262 90543158
Abdominal pain lower 87.87 46.49 42 5985 30135 90592285
Ectopic pregnancy 80.02 46.49 22 6005 3219 90619201
Haemoconcentration 72.21 46.49 12 6015 150 90622270
Ovarian cyst ruptured 71.02 46.49 17 6010 1435 90620985
Intra-abdominal haemorrhage 70.05 46.49 19 6008 2643 90619777
Abortion missed 65.77 46.49 17 6010 1965 90620455
Blood oestrogen increased 61.63 46.49 11 6016 214 90622206
Abortion 59.98 46.49 17 6010 2778 90619642
Incorrect dose administered 59.24 46.49 46 5981 78884 90543536
Drug level decreased 56.27 46.49 22 6005 9708 90612712
Pelvic pain 56.02 46.49 25 6002 15332 90607088
Chest discomfort 54.52 46.49 56 5971 138309 90484111
Circumstance or information capable of leading to medication error 54.32 46.49 18 6009 4949 90617471
Multiple pregnancy 51.95 46.49 8 6019 59 90622361
Waist circumference increased 50.95 46.49 12 6015 945 90621475
Premature ovulation 50.15 46.49 7 6020 23 90622397
Blood luteinising hormone increased 46.59 46.49 8 6019 123 90622297

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 6958.53 51.69 942 3966 4418 110579973
Ascites 803.52 51.69 254 4654 92554 110491837
Abdominal distension 402.86 51.69 182 4726 174921 110409470
Ovarian enlargement 260.12 51.69 39 4869 373 110584018
Ovarian haemorrhage 226.68 51.69 34 4874 326 110584065
Pelvic fluid collection 190.86 51.69 34 4874 999 110583392
Abdominal pain 186.67 51.69 165 4743 512824 110071567
Maternal exposure before pregnancy 148.50 51.69 39 4869 7226 110577165
Adnexal torsion 147.03 51.69 24 4884 412 110583979
Haemoperitoneum 134.90 51.69 34 4874 5354 110579037
Tension 117.05 51.69 30 4878 5048 110579343
Pleural effusion 113.77 51.69 80 4828 177629 110406762
Progesterone increased 106.93 51.69 14 4894 42 110584349
Abdominal pain lower 95.65 51.69 42 4866 37241 110547150
Ovarian cyst ruptured 74.57 51.69 16 4892 1245 110583146
Haemoconcentration 72.81 51.69 12 4896 219 110584172
Blood oestrogen increased 66.83 51.69 11 4897 199 110584192
Abortion missed 65.99 51.69 15 4893 1522 110582869
Abortion spontaneous 61.05 51.69 30 4878 34252 110550139
Intra-abdominal haemorrhage 60.20 51.69 18 4890 5324 110579067
Chest discomfort 59.01 51.69 54 4854 173794 110410597
Pelvic pain 57.83 51.69 23 4885 15919 110568472
Poor quality device used 56.72 51.69 15 4893 2848 110581543
Premature ovulation 55.82 51.69 7 4901 13 110584378

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03GA04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
ATC G03GA05 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
ATC G03GA06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
ATC G03GA10 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
FDA CS M0009540 Gonadotropins
MeSH PA D006728 Hormones
FDA EPC N0000175838 Gonadotropin
CHEBI has role CHEBI:24621 hormone

Related Drugs by ATC class:

G03GA Gonadotropins 4 drugs
choriogonadotropin alfachorionic gonadotrophincorifollitropin alfalutropin alfa

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ovulation induction indication 61285001




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Induction or superovulation Indication

🐶 Veterinary products

ProductApplicantIngredients
Super-Ov Therio Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Follicle-stimulating hormone receptor GPCR AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D06269 KEGG_DRUG
4019254 VUID
N0000147458 NUI
4019253 VANDF
4019254 VANDF
4021069 VANDF
4021070 VANDF
4024094 VANDF
CHEBI:81569 CHEBI
CHEMBL4297955 ChEMBL_ID
CHEMBL5315064 ChEMBL_ID
CHEMBL1201692 ChEMBL_ID
CHEMBL5315126 ChEMBL_ID
C000620228 MESH_SUPPLEMENTAL_RECORD_UI
C571801 MESH_SUPPLEMENTAL_RECORD_UI
C571802 MESH_SUPPLEMENTAL_RECORD_UI
DB00066 DRUGBANK_ID
DB00094 DRUGBANK_ID
134404 RXNORM
4760 MMSL
5657 MMSL
7863 MMSL
7864 MMSL
d00570 MMSL
d04043 MMSL
002102 NDDF
006654 NDDF
006941 NDDF
006978 NDDF
103028007 SNOMEDCT_US
109042006 SNOMEDCT_US
109044007 SNOMEDCT_US
126185008 SNOMEDCT_US
25217009 SNOMEDCT_US
325781003 SNOMEDCT_US
395862009 SNOMEDCT_US
395920003 SNOMEDCT_US
725743001 SNOMEDCT_US
763577005 SNOMEDCT_US
768662008 SNOMEDCT_US
C0733758 UMLSCUI
D005640 MESH_DESCRIPTOR_UI
CHEMBL1201520 ChEMBL_ID
CHEMBL2108427 ChEMBL_ID
9503 INN_ID
9732 INN_ID
1919 INN_ID
7505 INN_ID
62819 PUBCHEM_CID
1157 IUPHAR_LIGAND_ID
076WHW89TW UNII
4798 INN_ID
D050477 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0313 INJECTION, SOLUTION 350 [iU] SUBCUTANEOUS BLA 27 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0316 INJECTION, SOLUTION 650 [iU] SUBCUTANEOUS BLA 27 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0326 INJECTION, SOLUTION 975 [iU] SUBCUTANEOUS BLA 27 sections
Gonal-f RFF Redi-ject HUMAN PRESCRIPTION DRUG LABEL 1 44087-1115 INJECTION, SOLUTION 300 [iU] SUBCUTANEOUS BLA 29 sections
Gonal-f RFF Redi-ject HUMAN PRESCRIPTION DRUG LABEL 1 44087-1116 INJECTION, SOLUTION 450 [iU] SUBCUTANEOUS BLA 29 sections
Gonal-f RFF Redi-ject HUMAN PRESCRIPTION DRUG LABEL 1 44087-1117 INJECTION, SOLUTION 900 [iU] SUBCUTANEOUS BLA 29 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 78206-129 INJECTION, SOLUTION 300 [iU] SUBCUTANEOUS BLA 27 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 78206-130 INJECTION, SOLUTION 600 [iU] SUBCUTANEOUS BLA 27 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 78206-131 INJECTION, SOLUTION 900 [iU] SUBCUTANEOUS BLA 27 sections