follitropin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4928 146479-72-3

Description:

MoleculeDescription

Synonyms:

  • follitropin delta
  • follitropin alfa
  • follitropin beta
  • follitropin alfa/beta
  • follicle-stimulating hormone
  • urofollitropin
  • follitropin
  • human follicle stimulating hormone
  • FSH
A protein extract of human menopausal urine in which LUTEINIZING HORMONE has been partially or completely removed. Urofollitropin represents FOLLICLE STIMULATING HORMONE from the urine.
  • Molecular weight: 22668.79
  • Formula: C975H1493N267O305S26
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 5077.47
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
75 U P
75 U P
75 U P
12 mcg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 18, 1986 FDA SERONO
Jan. 23, 2006 PMDA SERONO JAPAN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 3851.49 48.20 567 3372 2677 50598508
Ascites 632.04 48.20 193 3746 35668 50565517
No adverse event 232.11 48.20 90 3849 33488 50567697
Maternal exposure before pregnancy 169.04 48.20 46 3893 5551 50595634
Ovarian enlargement 153.09 48.20 27 3912 415 50600770
Haemoperitoneum 151.51 48.20 36 3903 2519 50598666
Inappropriate schedule of product administration 149.99 48.20 84 3855 71747 50529438
Product quality issue 145.68 48.20 63 3876 30795 50570390
Adnexal torsion 140.46 48.20 23 3916 220 50600965
Abdominal distension 127.51 48.20 76 3863 72827 50528358
Ovarian haemorrhage 107.65 48.20 19 3920 293 50600892
Pelvic fluid collection 101.80 48.20 21 3918 762 50600423
Product packaging quantity issue 100.62 48.20 22 3917 1058 50600127
Abortion spontaneous 98.50 48.20 53 3886 41719 50559466
Poor quality device used 93.89 48.20 23 3916 1828 50599357
Progesterone increased 92.00 48.20 13 3926 39 50601146
Pleural effusion 70.47 48.20 55 3884 81399 50519786
Ovarian cyst ruptured 63.54 48.20 15 3924 1018 50600167
Incorrect dose administered 60.81 48.20 41 3898 48373 50552812
Circumstance or information capable of leading to medication error 59.40 48.20 18 3921 3170 50598015
Abortion 57.36 48.20 16 3923 2108 50599077
Abortion missed 57.13 48.20 15 3924 1573 50599612
Ectopic pregnancy 55.91 48.20 16 3923 2311 50598874
Multiple pregnancy 51.85 48.20 8 3931 50 50601135
Premature ovulation 51.22 48.20 7 3932 15 50601170
Oestradiol decreased 48.60 48.20 7 3932 25 50601160

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 3846.89 52.48 521 2444 2324 64493443
Ascites 595.57 52.48 185 2780 61816 64433951
Ovarian enlargement 175.79 52.48 27 2938 296 64495471
Adnexal torsion 149.81 52.48 22 2943 173 64495594
Haemoperitoneum 139.34 52.48 33 2932 3882 64491885
Pelvic fluid collection 116.83 52.48 21 2944 627 64495140
Maternal exposure before pregnancy 111.73 52.48 27 2938 3456 64492311
Ovarian haemorrhage 111.63 52.48 18 2947 275 64495492
Progesterone increased 99.10 52.48 13 2952 38 64495729
Abdominal distension 93.72 52.48 57 2908 95937 64399830
Ovarian cyst ruptured 68.23 52.48 14 2951 847 64494920
Pleural effusion 68.08 52.48 52 2913 126507 64369260
Abortion missed 58.40 52.48 13 2952 1159 64494608
Product quality issue 57.98 52.48 28 2937 29771 64465996
Premature ovulation 55.93 52.48 7 2958 12 64495755

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03GA04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
ATC G03GA05 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
ATC G03GA06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
ATC G03GA10 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins
FDA CS M0009540 Gonadotropins
MeSH PA D006728 Hormones
FDA EPC N0000175838 Gonadotropin

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ovulation induction indication 61285001




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Induction or superovulation Indication

🐶 Veterinary products

ProductApplicantIngredients
Super-Ov Therio Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Follicle-stimulating hormone receptor GPCR AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D06269 KEGG_DRUG
4019254 VUID
N0000147458 NUI
4019253 VANDF
4019254 VANDF
4021069 VANDF
4021070 VANDF
4024094 VANDF
CHEBI:81569 CHEBI
CHEMBL4297955 ChEMBL_ID
CHEMBL1201692 ChEMBL_ID
CHEMBL2108427 ChEMBL_ID
C000620228 MESH_SUPPLEMENTAL_RECORD_UI
C571801 MESH_SUPPLEMENTAL_RECORD_UI
C571802 MESH_SUPPLEMENTAL_RECORD_UI
1157 IUPHAR_LIGAND_ID
9503 INN_ID
DB00066 DRUGBANK_ID
076WHW89TW UNII
62819 PUBCHEM_CID
DB00094 DRUGBANK_ID
134404 RXNORM
4760 MMSL
5657 MMSL
7863 MMSL
7864 MMSL
d00570 MMSL
d04043 MMSL
002102 NDDF
006654 NDDF
006941 NDDF
006978 NDDF
103028007 SNOMEDCT_US
109042006 SNOMEDCT_US
109044007 SNOMEDCT_US
126185008 SNOMEDCT_US
25217009 SNOMEDCT_US
325781003 SNOMEDCT_US
395862009 SNOMEDCT_US
395920003 SNOMEDCT_US
725743001 SNOMEDCT_US
763577005 SNOMEDCT_US
768662008 SNOMEDCT_US
D005640 MESH_DESCRIPTOR_UI
D050477 MESH_DESCRIPTOR_UI
C0733758 UMLSCUI
CHEMBL1201520 ChEMBL_ID
9732 INN_ID
1919 INN_ID
7505 INN_ID
4798 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0313 INJECTION, SOLUTION 350 [iU] SUBCUTANEOUS BLA 28 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0316 INJECTION, SOLUTION 650 [iU] SUBCUTANEOUS BLA 28 sections
Follistim AQ HUMAN PRESCRIPTION DRUG LABEL 1 0052-0326 INJECTION, SOLUTION 975 [iU] SUBCUTANEOUS BLA 28 sections
Gonal-f RFF Redi-ject HUMAN PRESCRIPTION DRUG LABEL 1 44087-1115 INJECTION, SOLUTION 300 [iU] SUBCUTANEOUS BLA 28 sections
Gonal-f RFF Redi-ject HUMAN PRESCRIPTION DRUG LABEL 1 44087-1116 INJECTION, SOLUTION 450 [iU] SUBCUTANEOUS BLA 28 sections
Gonal-f RFF Redi-ject HUMAN PRESCRIPTION DRUG LABEL 1 44087-1117 INJECTION, SOLUTION 900 [iU] SUBCUTANEOUS BLA 28 sections