corifollitropin alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5245 195962-23-3

Description:

MoleculeDescription

Synonyms:

  • corifollitropin alfa
  • elonva
  • Org 36286
  • FSH-CTP
Corifollitropin alfa is designed as a sustained follicle stimulant with the same pharmacodynamic profile as (rec)FSH, but with a markedly prolonged duration of FSH activity. Due to its ability to initiate and sustain multiple follicular growth for an entire week, a single subcutaneous injection of the recommended dose of Corifollitropin alfa may replace the first seven injections of any daily (rec)FSH preparation in a COS treatment cycle. The long duration of FSH activity was achieved by adding the carboxy-terminal peptide of the beta-subunit of human chorionic gonadotropin (hCG) to the beta-chain of human FSH. Corifollitropin alfa does not display any intrinsic LH/hCG activity.
  • Molecular weight: 25471.11
  • Formula: C1098H1714N300O345S26
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 6163.54
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.15 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 25, 2010 EMA Merck Sharp & Dohme Limited

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 92.60 75.10 11 9 4003 63484999

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 96.39 80.90 11 9 3560 79740808

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03GA09 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Gonadotropins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Adolescent males with hypogonadotropic hypogonadism indication 33927004
Ovulation induction indication 61285001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Follicle-stimulating hormone receptor GPCR AGONIST SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
T7K20Y2GWY UNII
C2713522 UMLSCUI
CHEMBL2108185 ChEMBL_ID
DB09066 DRUGBANK_ID
D08895 KEGG_DRUG
7738 INN_ID
013500 NDDF
703830001 SNOMEDCT_US
715488000 SNOMEDCT_US
C437186 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None