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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
humanized origin	4909	216503-57-0

Description:

Molecule	Description
Synonyms: campath alemtuzumab lemtrada	Alemtuzumab binds to CD52, an antigen present on the surface of B and T lymphocytes, a majority of monocytes, macrophages, NK cells, and a subpopulation of granulocytes. A proportion of bone marrow cells, including some CD34+ cells, express variable levels of CD52. The proposed mechanism of action is antibody-dependent cellular-mediated lysis following cell surface binding of alemtuzumab to the leukemic cells. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

campath
alemtuzumab
lemtrada

Alemtuzumab binds to CD52, an antigen present on the surface of B and T lymphocytes, a majority of monocytes, macrophages, NK cells, and a subpopulation of granulocytes. A proportion of bone marrow cells, including some CD34+ cells, express variable levels of CD52. The proposed mechanism of action is antibody-dependent cellular-mediated lysis following cell surface binding of alemtuzumab to the leukemic cells.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.13	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Sept. 26, 2014	PMDA	SANOFI K.K.
May 7, 2001	FDA	GENZYME

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Lymphocyte count decreased	1028.72	16.41	449	44672	34601	90548725
Immune thrombocytopenia	928.05	16.41	320	44801	13006	90570320
Urine abnormality	797.74	16.41	250	44871	7487	90575839
Multiple sclerosis relapse	576.20	16.41	346	44775	51959	90531367
Urinary sediment present	522.64	16.41	136	44985	2038	90581288
Urine leukocyte esterase positive	511.78	16.41	146	44975	3136	90580190
Red blood cells urine positive	478.43	16.41	138	44983	3087	90580239
White blood cells urine positive	475.51	16.41	162	44959	6336	90576990
Cytomegalovirus infection	466.21	16.41	239	44882	26363	90556963
Adenovirus infection	421.28	16.41	136	44985	4486	90578840
Lymphocyte percentage decreased	420.55	16.41	124	44997	3003	90580323
Blood urine present	403.92	16.41	189	44932	17089	90566237
Crystal urine present	391.23	16.41	100	45021	1390	90581936
Lymphopenia	390.62	16.41	202	44919	22679	90560647
Neutrophil percentage increased	386.05	16.41	115	45006	2888	90580438
Urine analysis abnormal	381.37	16.41	130	44991	5091	90578235
Autoimmune thyroiditis	298.99	16.41	112	45009	5781	90577545
Bacterial test positive	294.67	16.41	109	45012	5430	90577896
Graft versus host disease in skin	293.45	16.41	99	45022	3754	90579572
Urine ketone body present	277.83	16.41	86	45035	2466	90580860
Flushing	276.94	16.41	277	44844	88214	90495112
Bacterial test	268.09	16.41	70	45051	1063	90582263
Blood thyroid stimulating hormone decreased	251.38	16.41	98	45023	5642	90577684
Hyperthyroidism	249.00	16.41	139	44982	18171	90565155
Bradycardia	245.10	16.41	253	44868	83594	90499732
Nitrite urine present	237.75	16.41	63	45058	1016	90582310
Red cell distribution width increased	226.41	16.41	114	45007	12093	90571233
Acute graft versus host disease in skin	225.39	16.41	86	45035	4670	90578656
Culture urine positive	195.14	16.41	73	45048	3752	90579574
Post transplant lymphoproliferative disorder	193.87	16.41	86	45035	6863	90576463
Haematocrit decreased	189.32	16.41	161	44960	41671	90541655
Haemoglobin urine present	188.34	16.41	49	45072	733	90582593
Chest discomfort	187.69	16.41	284	44837	138081	90445245
Epstein-Barr virus infection	187.15	16.41	95	45026	10249	90573077
Blood thyroid stimulating hormone increased	186.09	16.41	91	45030	9064	90574262
Platelet count decreased	181.35	16.41	278	44843	136691	90446635
Drug intolerance	170.58	16.41	14	45107	447577	90135749
Graft versus host disease	165.68	16.41	81	45040	8063	90575263
Viraemia	163.96	16.41	52	45069	1617	90581709
Varicella zoster virus infection	162.05	16.41	64	45057	3813	90579513
Cytomegalovirus infection reactivation	159.95	16.41	78	45043	7722	90575604
Protein urine present	158.88	16.41	75	45046	6909	90576417
Monocyte percentage increased	158.48	16.41	47	45074	1161	90582165
Specific gravity urine decreased	158.47	16.41	43	45078	762	90582564
Leukocyturia	157.12	16.41	50	45071	1572	90581754
Headache	154.14	16.41	839	44282	861907	89721419
Systemic lupus erythematosus	154.10	16.41	6	45115	361890	90221436
Cytomegalovirus viraemia	152.98	16.41	75	45046	7511	90575815
Rheumatoid arthritis	151.12	16.41	7	45114	362607	90220719
Neutrophil count increased	150.59	16.41	103	45018	19287	90564039
Arthropathy	146.60	16.41	9	45112	366233	90217093
Drug hypersensitivity	146.34	16.41	27	45094	463582	90119744
Pyrexia	144.26	16.41	680	44441	659805	89923521
White blood cell count decreased	143.43	16.41	280	44841	166829	90416497
Synovitis	142.00	16.41	5	45116	329747	90253579
Graft versus host disease in gastrointestinal tract	141.00	16.41	60	45061	4328	90578998
Magnetic resonance imaging abnormal	140.31	16.41	56	45065	3430	90579896
Mean cell haemoglobin decreased	138.35	16.41	64	45057	5631	90577695
Contraindicated product administered	137.34	16.41	5	45116	320134	90263192
BK virus infection	136.28	16.41	59	45062	4439	90578887
Thyroxine free increased	134.92	16.41	40	45081	987	90582339
Joint swelling	134.05	16.41	42	45079	503258	90080068
Herpes zoster	130.75	16.41	196	44925	94448	90488878
Monocyte count decreased	130.54	16.41	49	45072	2542	90580784
Endocrine ophthalmopathy	128.85	16.41	39	45082	1035	90582291
Product dose omission issue	127.08	16.41	4	45117	291683	90291643
Anti-thyroid antibody positive	119.19	16.41	31	45090	463	90582863
Herpes simplex	113.67	16.41	68	45053	10113	90573213
Swelling	113.29	16.41	34	45087	419024	90164302
Autoimmune haemolytic anaemia	111.41	16.41	55	45066	5590	90577736
Maternal exposure during pregnancy	111.39	16.41	22	45099	360041	90223285
Wound	111.26	16.41	11	45110	302969	90280357
Drug ineffective	110.33	16.41	340	44781	1383958	89199368
Drug monitoring procedure not performed	109.29	16.41	32	45089	755	90582571
Thrombotic microangiopathy	109.12	16.41	78	45043	15665	90567661
Tachycardia	105.88	16.41	239	44882	157434	90425892
Feeling hot	105.53	16.41	160	44961	77848	90505478
Epstein-Barr viraemia	104.99	16.41	36	45085	1434	90581892
Hypothyroidism	103.56	16.41	130	44991	52997	90530329
Transplant failure	101.98	16.41	38	45083	1931	90581395
Urinary casts	99.99	16.41	30	45091	772	90582554
Treatment failure	99.57	16.41	16	45105	303912	90279414
Autoimmune thyroid disorder	97.93	16.41	16	45105	10	90583316
Body temperature increased	97.85	16.41	116	45005	44594	90538732
Impaired healing	95.99	16.41	5	45116	234194	90349132
Monocyte count increased	94.46	16.41	58	45063	9039	90574287
Venoocclusive disease	93.84	16.41	38	45083	2417	90580909
Hepatic enzyme increased	92.64	16.41	32	45089	360704	90222622
CD4 lymphocytes decreased	91.78	16.41	33	45088	1514	90581812
Pericarditis	88.99	16.41	14	45107	270137	90313189
Eosinophil count increased	88.80	16.41	64	45057	13017	90570309
Product use issue	88.71	16.41	27	45094	329892	90253434
Alopecia	88.71	16.41	70	45051	495001	90088325
Red blood cells urine	88.50	16.41	25	45096	517	90582809
Irritable bowel syndrome	86.39	16.41	4	45117	207444	90375882
Mean cell volume decreased	86.25	16.41	43	45078	4463	90578863
Infusion site pain	85.27	16.41	74	45047	19664	90563662
Heavy menstrual bleeding	84.74	16.41	75	45046	20455	90562871
Blood thyroid stimulating hormone abnormal	84.68	16.41	28	45093	996	90582330
Listeriosis	84.32	16.41	32	45089	1711	90581615
Urobilinogen urine increased	83.44	16.41	21	45100	273	90583053
Drug interaction	83.18	16.41	18	45103	276435	90306891
Leukopenia	83.02	16.41	166	44955	100544	90482782
Epstein-Barr virus infection reactivation	82.62	16.41	31	45090	1606	90581720
Chills	81.92	16.41	194	44927	131787	90451539
Folliculitis	81.78	16.41	5	45116	204348	90378978
Injury	81.55	16.41	4	45117	197345	90385981
Red blood cell count decreased	80.29	16.41	107	45014	46244	90537082
Pain	79.64	16.41	244	44877	996097	89587229
Red blood cell count increased	79.43	16.41	38	45083	3605	90579721
Type 2 diabetes mellitus	78.34	16.41	6	45115	203238	90380088
Osteoarthritis	77.69	16.41	5	45116	195725	90387601
Haemoglobin decreased	77.68	16.41	216	44905	161740	90421586
Death	77.52	16.41	68	45053	456483	90126843
Gastrointestinal disorder	76.64	16.41	17	45104	256670	90326656
Urinary tract infection	76.43	16.41	328	44793	305304	90278022
Cells in urine	76.11	16.41	18	45103	177	90583149
Hypersensitivity	75.67	16.41	69	45052	454608	90128718
Transplant rejection	74.46	16.41	57	45064	12701	90570625
Petechiae	74.10	16.41	62	45059	15679	90567647
Red cell distribution width decreased	73.79	16.41	31	45090	2165	90581161
Growth failure	72.95	16.41	20	45101	369	90582957
Urinary tract infection bacterial	72.83	16.41	43	45078	6242	90577084
Lymphocyte count abnormal	72.39	16.41	24	45097	861	90582465
Mucosal inflammation	72.05	16.41	114	45007	57511	90525815
Multiple sclerosis	70.66	16.41	78	45043	27762	90555564
Idiopathic pneumonia syndrome	70.02	16.41	20	45101	431	90582895
Urine leukocyte esterase	67.59	16.41	16	45105	158	90583168
Acute graft versus host disease	67.56	16.41	39	45082	5429	90577897
Discomfort	65.95	16.41	27	45094	274308	90309018
Eosinophil percentage increased	65.35	16.41	23	45098	991	90582335
Stomatitis	64.49	16.41	28	45093	274670	90308656
CD4 lymphocytes abnormal	64.25	16.41	12	45109	30	90583296
Poor quality sleep	64.09	16.41	70	45051	24623	90558703
Mean cell haemoglobin concentration decreased	63.99	16.41	35	45086	4393	90578933
Blood creatinine decreased	63.75	16.41	40	45081	6475	90576851
pH urine increased	63.23	16.41	18	45103	383	90582943
Tri-iodothyronine free decreased	63.14	16.41	18	45103	385	90582941
Neutropenia	62.99	16.41	250	44871	224654	90358672
Feeling cold	62.99	16.41	73	45048	27392	90555934
Thrombocytopenia	62.51	16.41	237	44884	208488	90374838
Abdominal discomfort	62.47	16.41	88	45033	477240	90106086
Band sensation	62.08	16.41	23	45098	1150	90582176
Acute graft versus host disease in intestine	62.05	16.41	27	45094	2056	90581270
Injection site pain	61.95	16.41	7	45114	173692	90409634
Human herpesvirus 6 infection	60.56	16.41	31	45090	3401	90579925
Overdose	59.81	16.41	5	45116	157704	90425622
Autoimmune hypothyroidism	59.69	16.41	16	45105	270	90583056
Heart rate increased	59.56	16.41	156	44965	112746	90470580
Infusion related reaction	59.50	16.41	72	45049	416708	90166618
Cellulitis staphylococcal	59.29	16.41	21	45100	922	90582404
Multiple organ dysfunction syndrome	59.16	16.41	115	45006	68221	90515105
Arthralgia	58.37	16.41	196	44925	778326	89805000
Peripheral swelling	58.30	16.41	72	45049	413034	90170292
Tri-iodothyronine free increased	58.24	16.41	15	45106	215	90583111
Encephalitis viral	57.95	16.41	25	45096	1864	90581462
Thyroxine free decreased	57.59	16.41	20	45101	828	90582498
Thyroid function test abnormal	56.18	16.41	31	45090	3958	90579368
Growth retardation	56.03	16.41	24	45097	1759	90581567
Menstruation irregular	56.00	16.41	40	45081	8020	90575306
Mean cell haemoglobin concentration increased	55.64	16.41	18	45103	597	90582729
Therapeutic product effect incomplete	55.58	16.41	14	45107	193882	90389444
Diarrhoea	55.48	16.41	260	44861	938930	89644396
Band neutrophil percentage increased	53.59	16.41	14	45107	213	90583113
Muscular weakness	53.32	16.41	224	44897	206442	90376884
Viral haemorrhagic cystitis	53.28	16.41	22	45099	1471	90581855
Meningitis listeria	53.18	16.41	18	45103	689	90582637
Haemophagocytic lymphohistiocytosis	53.16	16.41	51	45070	15408	90567918
Confusional state	52.73	16.41	69	45052	386136	90197190
Polyomavirus viraemia	52.46	16.41	21	45100	1296	90582030
Blood cholesterol increased	52.42	16.41	19	45102	207993	90375333
Blister	52.35	16.41	31	45090	254967	90328359
Specific gravity urine increased	52.03	16.41	14	45107	240	90583086
White blood cells urine	51.90	16.41	16	45105	452	90582874
Thyroid stimulating immunoglobulin	51.29	16.41	11	45110	66	90583260
Eosinophil percentage decreased	51.23	16.41	14	45107	255	90583071
Sleep disorder	50.05	16.41	18	45103	198012	90385314
Bronchiolitis obliterans syndrome	49.63	16.41	15	45106	396	90582930
Myelocyte count increased	49.45	16.41	15	45106	401	90582925
Gastroenteritis norovirus	49.43	16.41	24	45097	2352	90580974
Pulmonary haemorrhage	47.20	16.41	36	45085	7977	90575349
Actinomycotic sepsis	47.05	16.41	13	45108	247	90583079
Oropharyngeal pain	46.94	16.41	145	44976	115042	90468284
Monocyte percentage decreased	46.52	16.41	13	45108	258	90583068
Toxicity to various agents	46.29	16.41	45	45076	287801	90295525
Menstrual disorder	46.22	16.41	32	45089	6106	90577220
Arthritis	46.21	16.41	13	45108	167302	90416024
C-reactive protein abnormal	45.78	16.41	5	45116	127424	90455902
Band neutrophil count increased	45.43	16.41	14	45107	395	90582931
Herpes zoster infection neurological	45.41	16.41	15	45106	532	90582794
Gingival bleeding	45.36	16.41	46	45075	14857	90568469
Intentional product use issue	45.04	16.41	26	45095	216866	90366460
Central nervous system lesion	45.01	16.41	41	45080	11605	90571721
Crystalluria	45.01	16.41	15	45106	547	90582779
Creatinine urine decreased	44.79	16.41	13	45108	297	90583029
Joint range of motion decreased	44.71	16.41	7	45114	135636	90447690
Pulmonary alveolar haemorrhage	44.53	16.41	31	45090	5967	90577359
Guillain-Barre syndrome	44.33	16.41	28	45093	4584	90578742
Psoriasis	43.65	16.41	10	45111	147744	90435582
Asthma	43.61	16.41	34	45087	242126	90341200
Chronic graft versus host disease in liver	43.38	16.41	13	45108	333	90582993
Platelet count abnormal	43.38	16.41	27	45094	4308	90579018
Urine oxalate increased	43.34	16.41	12	45109	230	90583096
Optic neuritis	43.25	16.41	37	45084	9641	90573685
Expanded disability status scale score increased	43.05	16.41	16	45105	807	90582519
T-lymphocyte count decreased	42.98	16.41	13	45108	344	90582982
Vitiligo	42.96	16.41	21	45100	2089	90581237
Heart rate decreased	42.65	16.41	87	45034	53418	90529908
Acute disseminated encephalomyelitis	42.48	16.41	12	45109	248	90583078
Immune reconstitution inflammatory syndrome	42.37	16.41	32	45089	6987	90576339
Aplastic anaemia	42.31	16.41	42	45079	13227	90570099
Infusion site extravasation	41.17	16.41	37	45084	10291	90573035
Myelocyte percentage increased	41.13	16.41	11	45110	184	90583142
Posterior reversible encephalopathy syndrome	40.89	16.41	53	45068	22286	90561040
Proteinuria	40.69	16.41	54	45067	23237	90560089
Bacteriuria	40.44	16.41	17	45104	1189	90582137
Bilirubin urine present	40.40	16.41	9	45112	66	90583260
Sinusitis	39.38	16.41	69	45052	343019	90240307
Lower respiratory tract infection	39.36	16.41	40	45081	250619	90332707
Musculoskeletal pain	39.32	16.41	18	45103	171233	90412093
Neutrophil count decreased	38.90	16.41	100	45021	71432	90511894
Adverse drug reaction	38.51	16.41	6	45115	116695	90466631
Musculoskeletal stiffness	38.42	16.41	55	45066	296477	90286849
Feeling abnormal	37.60	16.41	174	44947	167061	90416265
Acute myeloid leukaemia recurrent	37.52	16.41	19	45102	2038	90581288
Oedema	37.50	16.41	27	45094	200268	90383058
Cystitis haemorrhagic	37.48	16.41	27	45094	5486	90577840
Lymphadenopathy	37.16	16.41	75	45046	45700	90537626
Sinus bradycardia	37.11	16.41	44	45077	16908	90566418
Drug exposure before pregnancy	37.08	16.41	15	45106	951	90582375
Thrombotic thrombocytopenic purpura	36.99	16.41	24	45097	4114	90579212
Adverse event	36.63	16.41	7	45114	117411	90465915
Oesophageal candidiasis	36.57	16.41	29	45092	6800	90576526
Quadriparesis	36.42	16.41	20	45101	2529	90580797
Sciatica	36.36	16.41	4	45117	101378	90481948
Obesity	35.79	16.41	5	45116	105502	90477824
Infection reactivation	35.62	16.41	18	45103	1922	90581404
Haematuria	35.50	16.41	63	45058	34874	90548452
Throat irritation	35.11	16.41	76	45045	48619	90534707
Anti-glomerular basement membrane disease	34.66	16.41	8	45113	70	90583256
Limb discomfort	34.09	16.41	65	45056	37995	90545331
Glomerulonephritis membranous	33.99	16.41	13	45108	710	90582616
Exophthalmos	33.91	16.41	17	45104	1785	90581541
Haemorrhagic adrenal infarction	33.55	16.41	7	45114	36	90583290
Chronic graft versus host disease in skin	33.48	16.41	15	45106	1225	90582101
Mean cell haemoglobin increased	33.33	16.41	22	45099	3883	90579443
Autoimmune neutropenia	33.23	16.41	10	45111	260	90583066
Focal nodular hyperplasia	33.16	16.41	13	45108	759	90582567
Cytomegalovirus oesophagitis	32.91	16.41	11	45110	405	90582921
Fall	32.90	16.41	126	44995	481684	90101642
Eye infection toxoplasmal	32.75	16.41	11	45110	411	90582915
Injection site erythema	32.65	16.41	5	45116	98497	90484829
Bronchopulmonary aspergillosis	32.56	16.41	34	45087	11364	90571962
Autoimmune pancytopenia	32.37	16.41	8	45113	96	90583230
Injection site reaction	32.11	16.41	4	45117	92076	90491250
Periportal oedema	31.96	16.41	7	45114	47	90583279
Gastroenteritis adenovirus	31.90	16.41	10	45111	299	90583027
Decreased appetite	31.53	16.41	90	45031	376450	90206876
Delayed graft function	31.48	16.41	15	45106	1410	90581916
Basophil count increased	31.32	16.41	14	45107	1137	90582189
Granulocyte percentage	31.00	16.41	7	45114	55	90583271
Fibrin D dimer increased	31.00	16.41	24	45097	5436	90577890
B-lymphocyte count increased	30.79	16.41	8	45113	119	90583207
Basophil percentage increased	30.79	16.41	8	45113	119	90583207
Hypogammaglobulinaemia	30.77	16.41	32	45089	10642	90572684
Thyroid disorder	30.70	16.41	41	45080	17744	90565582
Mean cell volume increased	30.55	16.41	23	45098	4998	90578328
Dry mouth	30.48	16.41	28	45093	184031	90399295
Oedema peripheral	30.38	16.41	51	45070	257864	90325462
Drug abuse	30.17	16.41	3	45118	82344	90500982
Immature granulocyte count increased	30.10	16.41	11	45110	529	90582797
Progressive multifocal leukoencephalopathy	30.00	16.41	38	45083	15617	90567709
Vulvovaginal mycotic infection	29.99	16.41	25	45096	6289	90577037
Thyroid stimulating immunoglobulin increased	29.96	16.41	8	45113	133	90583193
Pseudomonas infection	29.96	16.41	37	45084	14828	90568498
Mycobacterium kansasii infection	29.85	16.41	8	45113	135	90583191
Post procedural hypothyroidism	29.79	16.41	10	45111	373	90582953
Urticaria	29.65	16.41	261	44860	312473	90270853
Pulmonary nocardiosis	29.29	16.41	12	45109	786	90582540
Atrial fibrillation	29.21	16.41	15	45106	133596	90449730
Pollakiuria	29.11	16.41	56	45065	32949	90550377
Creatinine urine increased	29.10	16.41	9	45112	257	90583069
Listeria test positive	29.09	16.41	5	45116	6	90583320
Lipaemic index score	29.05	16.41	7	45114	75	90583251
General physical health deterioration	28.91	16.41	86	45035	355029	90228297
Lower limb fracture	28.91	16.41	4	45117	85009	90498317
Bacterial sepsis	28.61	16.41	22	45099	4933	90578393
Haemolytic anaemia	28.35	16.41	32	45089	11665	90571661
Pathogen resistance	28.33	16.41	27	45094	8088	90575238
Bone marrow transplant rejection	28.33	16.41	7	45114	84	90583242
Joint stiffness	28.19	16.41	3	45118	78039	90505287
Mean platelet volume increased	27.94	16.41	12	45109	885	90582441
Herpes simplex pneumonia	27.88	16.41	7	45114	90	90583236
Staphylococcal infection	27.67	16.41	69	45052	48370	90534956
Palpitations	27.65	16.41	138	44983	136590	90446736
Cough	27.63	16.41	293	44828	368669	90214657
Neuropathy peripheral	27.61	16.41	17	45104	136953	90446373
Chronic graft versus host disease	27.52	16.41	20	45101	4119	90579207
Parvovirus infection	27.20	16.41	10	45111	489	90582837
Eosinophil count decreased	27.18	16.41	18	45103	3194	90580132
Road traffic accident	26.82	16.41	10	45111	107616	90475710
Legionella infection	26.82	16.41	10	45111	509	90582817
Weight increased	26.80	16.41	112	45009	417815	90165511
White blood cell count increased	26.78	16.41	84	45037	67157	90516169
Dysuria	26.71	16.41	60	45061	39341	90543985
Goitre	26.50	16.41	24	45097	6743	90576583
Insomnia	26.47	16.41	268	44853	333206	90250120
Goodpasture's syndrome	26.42	16.41	4	45117	0	90583326
Exposure during pregnancy	26.40	16.41	49	45072	238361	90344965
Haemoptysis	26.34	16.41	54	45067	33266	90550060
Micturition urgency	25.99	16.41	30	45091	11203	90572123
Temperature intolerance	25.96	16.41	31	45090	11999	90571327
Erythema	25.84	16.41	199	44922	229047	90354279
Tremor	25.79	16.41	147	44974	153026	90430300
Depressed level of consciousness	25.78	16.41	3	45118	72781	90510545
Haematocrit increased	25.44	16.41	17	45104	3061	90580265
Pneumonitis	25.32	16.41	63	45058	44107	90539219
Infertility	25.05	16.41	11	45110	856	90582470
Oral herpes	24.94	16.41	53	45068	33471	90549855
Glomerulonephritis chronic	24.91	16.41	7	45114	142	90583184
Malignant melanoma	24.86	16.41	31	45090	12545	90570781
Platelet count increased	24.34	16.41	40	45081	20819	90562507
Graft loss	24.29	16.41	9	45112	450	90582876
Chromaturia	24.03	16.41	38	45083	19149	90564177
Citrobacter infection	23.92	16.41	10	45111	690	90582636
Delirium	23.90	16.41	11	45110	104348	90478978
Chronic obstructive pulmonary disease	23.90	16.41	4	45117	73825	90509501
Retinal depigmentation	23.77	16.41	8	45113	301	90583025
Mean platelet volume decreased	23.68	16.41	16	45105	2934	90580392
Lymphodepletion	23.61	16.41	5	45116	28	90583298
Cervical dysplasia	23.49	16.41	18	45103	4016	90579310
Drug-induced liver injury	23.17	16.41	8	45113	90310	90493016
Myocardial infarction	23.01	16.41	12	45109	105960	90477366
Venoocclusive liver disease	22.97	16.41	21	45100	5972	90577354
Meningism	22.95	16.41	9	45112	526	90582800
Cytomegalovirus gastritis	22.92	16.41	8	45113	336	90582990
Pneumonia cytomegaloviral	22.91	16.41	16	45105	3095	90580231
Epstein-Barr virus associated lymphoproliferative disorder	22.70	16.41	15	45106	2652	90580674
Neutrophil percentage decreased	22.66	16.41	9	45112	544	90582782
JC polyomavirus test positive	22.65	16.41	13	45108	1789	90581537
White blood cell count abnormal	22.54	16.41	23	45098	7481	90575845
Oesophagitis ulcerative	22.44	16.41	10	45111	806	90582520
Hyperplasia	22.32	16.41	11	45110	1113	90582213
Nasal septum disorder	22.28	16.41	7	45114	211	90583115
Alanine aminotransferase increased	22.22	16.41	117	45004	118221	90465105
Loss of personal independence in daily activities	22.19	16.41	21	45100	136084	90447242
Hemiparesis	22.18	16.41	49	45072	31770	90551556
Hypoglycaemia	22.14	16.41	4	45117	69844	90513482
Vision blurred	22.07	16.41	111	45010	110182	90473144
Incorrect dose administered	22.03	16.41	6	45115	78924	90504402
Clostridium difficile colitis	21.96	16.41	44	45077	26662	90556664
Parotitis	21.86	16.41	13	45108	1912	90581414
Systemic mycosis	21.85	16.41	12	45109	1518	90581808
Rectal haemorrhage	21.80	16.41	7	45114	82737	90500589
Cytomegalovirus chorioretinitis	21.55	16.41	14	45107	2405	90580921
Ureaplasma infection	21.45	16.41	10	45111	895	90582431
Urine odour abnormal	21.39	16.41	22	45099	7222	90576104
Immature granulocyte percentage increased	21.34	16.41	5	45116	47	90583279
Lung disorder	21.24	16.41	26	45095	149857	90433469
Gait inability	21.18	16.41	25	45096	146431	90436895
Fungal skin infection	21.15	16.41	19	45102	5282	90578044
Maternal exposure before pregnancy	21.15	16.41	27	45094	11186	90572140
Thyroid cyst	21.04	16.41	9	45112	657	90582669
Cystitis viral	21.04	16.41	7	45114	254	90583072
Hepatitis infectious mononucleosis	20.89	16.41	6	45115	132	90583194
Cytomegalovirus test positive	20.86	16.41	16	45105	3575	90579751
Monocyte count abnormal	20.80	16.41	7	45114	263	90583063
Sepsis	20.77	16.41	157	44964	179657	90403669
Liver disorder	20.61	16.41	18	45103	121251	90462075
Suicide attempt	20.55	16.41	6	45115	75393	90507933
Malignant neoplasm progression	20.53	16.41	14	45107	106856	90476470
Fungal infection	20.52	16.41	57	45064	42604	90540722
Organising pneumonia	20.52	16.41	22	45099	7575	90575751
Ill-defined disorder	20.46	16.41	38	45083	184853	90398473
Fumbling	20.43	16.41	6	45115	143	90583183
Serum amyloid A protein increased	20.40	16.41	9	45112	708	90582618
Loefgren syndrome	20.39	16.41	6	45115	144	90583182
Vaccination site inflammation	20.31	16.41	5	45116	59	90583267
Post herpetic neuralgia	20.23	16.41	14	45107	2670	90580656
Laboratory test abnormal	20.21	16.41	56	45065	41798	90541528
Infusion site discomfort	19.93	16.41	12	45109	1804	90581522
Foot deformity	19.83	16.41	3	45118	59648	90523678
Diplopia	19.77	16.41	44	45077	28670	90554656
Fusarium infection	19.75	16.41	10	45111	1072	90582254
Encephalitis	19.73	16.41	26	45095	11108	90572218
Fungaemia	19.62	16.41	15	45106	3335	90579991
Nail disorder	19.57	16.41	3	45118	59064	90524262
Poor venous access	19.56	16.41	35	45086	19492	90563834
Relapsing-remitting multiple sclerosis	19.47	16.41	9	45112	790	90582536
Dysgeusia	19.42	16.41	64	45057	52496	90530830
Bladder dysfunction	19.39	16.41	10	45111	1114	90582212
Bronchostenosis	19.37	16.41	8	45113	535	90582791
Pancytopenia	19.32	16.41	114	45007	120149	90463177
Klebsiella test positive	19.32	16.41	11	45110	1492	90581834
No adverse event	19.29	16.41	5	45116	67977	90515349
Chronic hepatitis C	19.12	16.41	6	45115	180	90583146
Lymphocyte percentage increased	19.06	16.41	8	45113	557	90582769
Autoimmune arthritis	19.02	16.41	5	45116	78	90583248
Urinary incontinence	18.88	16.41	51	45070	37515	90545811
Cytokine storm	18.80	16.41	8	45113	577	90582749
Thyroiditis	18.53	16.41	15	45106	3622	90579704
Infusion site scar	18.52	16.41	8	45113	598	90582728
Thyroiditis subacute	18.52	16.41	7	45114	370	90582956
Microcytosis	18.49	16.41	6	45115	201	90583125
Nocardiosis	18.42	16.41	13	45108	2557	90580769
Organ failure	18.40	16.41	14	45107	3091	90580235
Blood luteinising hormone decreased	18.25	16.41	4	45117	27	90583299
Diffuse large B-cell lymphoma	18.20	16.41	22	45099	8623	90574703
Papillary thyroid cancer	18.16	16.41	13	45108	2614	90580712
Herpes virus infection	18.15	16.41	19	45102	6365	90576961
Autoimmune hepatitis	18.08	16.41	24	45097	10327	90572999
Drug resistance	18.05	16.41	44	45077	30405	90552921
Hyponatraemia	18.05	16.41	24	45097	133514	90449812
Blood stem cell transplant failure	18.00	16.41	6	45115	219	90583107
Tumefactive multiple sclerosis	17.95	16.41	5	45116	98	90583228
Anti-thyroid antibody	17.88	16.41	4	45117	30	90583296
CD4 lymphocyte percentage decreased	17.74	16.41	3	45118	3	90583323
Natural killer cell count increased	17.74	16.41	3	45118	3	90583323
Ataxia	17.64	16.41	32	45089	18010	90565316
Thyroxine decreased	17.58	16.41	8	45113	677	90582649
Gamma-glutamyltransferase increased	17.56	16.41	50	45071	37902	90545424
Nitrite urine	17.44	16.41	4	45117	34	90583292
Human polyomavirus infection	17.41	16.41	7	45114	437	90582889
Lymphocyte percentage abnormal	17.33	16.41	4	45117	35	90583291
Endometrial ablation	17.31	16.41	9	45112	1020	90582306
Disorder of globe	17.28	16.41	3	45118	4	90583322
Brain stem syndrome	17.16	16.41	8	45113	716	90582610
Extensor plantar response	17.16	16.41	10	45111	1417	90581909
Engraftment syndrome	17.15	16.41	8	45113	717	90582609
Pneumocystis jirovecii pneumonia	17.05	16.41	35	45086	21581	90561745
Listeria sepsis	17.03	16.41	8	45113	728	90582598
Influenza	16.88	16.41	123	44998	139141	90444185
Mobility decreased	16.81	16.41	66	45055	250668	90332658
Escherichia urinary tract infection	16.81	16.41	27	45094	13788	90569538
Peripheral coldness	16.69	16.41	27	45094	13865	90569461
Klebsiella infection	16.66	16.41	23	45098	10274	90573052
Hepatosplenomegaly	16.59	16.41	13	45108	2996	90580330
Albumin urine present	16.55	16.41	6	45115	282	90583044
Infusion site rash	16.51	16.41	12	45109	2471	90580855
Acute motor axonal neuropathy	16.51	16.41	4	45117	44	90583282
Urine bilirubin increased	16.51	16.41	4	45117	44	90583282
Tri-iodothyronine free abnormal	16.42	16.41	4	45117	45	90583281

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cytomegalovirus infection	652.05	16.46	334	24141	31972	42564888
Post transplant lymphoproliferative disorder	410.04	16.46	165	24310	8955	42587905
Immune thrombocytopenia	396.71	16.46	171	24304	11045	42585815
Adenovirus infection	322.75	16.46	128	24347	6681	42590179
Cytomegalovirus infection reactivation	249.87	16.46	124	24351	11054	42585806
Lymphopenia	249.51	16.46	155	24320	21408	42575452
Epstein-Barr virus infection	244.85	16.46	117	24358	9601	42587259
Autoimmune haemolytic anaemia	232.27	16.46	96	24379	5575	42591285
Multiple sclerosis relapse	199.89	16.46	116	24359	14148	42582712
Progressive multifocal leukoencephalopathy	191.96	16.46	105	24370	11431	42585429
Graft versus host disease	186.14	16.46	107	24368	12818	42584042
Lymphocyte count decreased	173.73	16.46	137	24338	27672	42569188
JC virus infection	172.70	16.46	65	24410	2939	42593921
Microsporidia infection	171.31	16.46	51	24424	1101	42595759
Transplant failure	167.43	16.46	69	24406	3975	42592885
BK virus infection	157.43	16.46	84	24391	8700	42588160
Lymphocyte percentage decreased	144.99	16.46	53	24422	2206	42594654
Pyrexia	144.99	16.46	525	23950	393517	42203343
Herpes simplex	144.73	16.46	74	24401	7021	42589839
Chronic graft versus host disease in skin	127.03	16.46	44	24431	1562	42595298
Graft versus host disease in gastrointestinal tract	123.71	16.46	60	24415	5083	42591777
Graft versus host disease in skin	122.94	16.46	60	24415	5152	42591708
Acute graft versus host disease in skin	119.16	16.46	66	24409	7358	42589502
Mucosal inflammation	118.64	16.46	144	24331	49230	42547630
Transplant rejection	116.45	16.46	81	24394	13507	42583353
End stage renal disease	108.63	16.46	84	24391	16474	42580386
Cytomegalovirus viraemia	108.50	16.46	70	24405	10307	42586553
Neutrophil percentage increased	107.47	16.46	41	24434	1924	42594936
Epstein-Barr virus infection reactivation	105.96	16.46	44	24431	2583	42594277
Monocyte percentage increased	99.55	16.46	33	24442	1022	42595838
Crystal urine present	98.21	16.46	27	24448	433	42596427
Aplastic anaemia	86.00	16.46	65	24410	12319	42584541
Acute graft versus host disease	82.40	16.46	54	24421	8161	42588699
Drug interaction	81.52	16.46	26	24449	266973	42329887
Off label use	79.74	16.46	631	23844	637704	41959156
Polymyositis	79.37	16.46	32	24443	1741	42595119
Pulmonary nocardiosis	78.69	16.46	32	24443	1780	42595080
Herpes zoster	78.49	16.46	104	24371	38773	42558087
Haemolytic anaemia	76.24	16.46	60	24415	12067	42584793
Aspergillus infection	75.97	16.46	67	24408	15770	42581090
Product use in unapproved indication	73.65	16.46	253	24222	184203	42412657
Multiple organ dysfunction syndrome	73.38	16.46	168	24307	96867	42499993
Diffuse large B-cell lymphoma	73.24	16.46	53	24422	9401	42587459
Acute graft versus host disease in intestine	68.59	16.46	37	24438	3914	42592946
Thrombotic microangiopathy	67.85	16.46	61	24414	14721	42582139
Meningitis viral	67.49	16.46	25	24450	1080	42595780
Chronic graft versus host disease in liver	66.90	16.46	22	24453	664	42596196
Urine abnormality	65.80	16.46	30	24445	2209	42594651
Human herpesvirus 6 infection	65.40	16.46	31	24444	2494	42594366
Epstein-Barr viraemia	65.17	16.46	30	24445	2259	42594601
Blood thyroid stimulating hormone decreased	64.74	16.46	30	24445	2293	42594567
Venoocclusive disease	63.35	16.46	35	24440	3880	42592980
Chronic graft versus host disease in intestine	62.39	16.46	19	24456	444	42596416
Pseudomonas infection	62.07	16.46	60	24415	15863	42580997
Urine analysis abnormal	60.11	16.46	28	24447	2166	42594694
Magnetic resonance imaging abnormal	59.49	16.46	26	24449	1732	42595128
Chronic graft versus host disease	58.96	16.46	39	24436	5986	42590874
Haemophagocytic lymphohistiocytosis	58.83	16.46	62	24413	18160	42578700
Endocrine ophthalmopathy	58.20	16.46	15	24460	185	42596675
Leukaemia recurrent	57.87	16.46	26	24449	1850	42595010
Lactobacillus infection	57.54	16.46	17	24458	357	42596503
Pancytopenia	57.37	16.46	173	24302	117570	42479290
Epstein-Barr virus associated lymphoproliferative disorder	57.24	16.46	28	24447	2415	42594445
Pneumonia cytomegaloviral	56.31	16.46	33	24442	4093	42592767
Bronchopulmonary aspergillosis	55.54	16.46	62	24413	19367	42577493
Autoimmune thyroiditis	55.50	16.46	24	24451	1558	42595302
Toxoplasmosis	55.14	16.46	24	24451	1583	42595277
Propionibacterium infection	54.77	16.46	15	24460	237	42596623
Red blood cells urine positive	54.27	16.46	25	24450	1885	42594975
Graft loss	53.32	16.46	20	24455	895	42595965
Adenovirus reactivation	52.33	16.46	16	24459	379	42596481
Acanthamoeba infection	51.92	16.46	17	24458	506	42596354
White blood cells urine positive	51.01	16.46	22	24453	1419	42595441
B-cell lymphoma	51.00	16.46	33	24442	4880	42591980
Epstein-Barr virus associated lymphoma	50.35	16.46	20	24455	1046	42595814
Specific gravity urine increased	49.88	16.46	13	24462	168	42596692
Death	49.48	16.46	125	24350	471060	42125800
Bacterial test positive	48.73	16.46	28	24447	3347	42593513
Pyelonephritis fungal	47.43	16.46	11	24464	84	42596776
Urine ketone body present	45.17	16.46	20	24455	1374	42595486
Dyspnoea	44.48	16.46	120	24355	442501	42154359
Blood thyroid stimulating hormone increased	44.05	16.46	31	24444	5261	42591599
Varicella	43.45	16.46	22	24453	2043	42594817
Arthralgia	43.00	16.46	33	24442	205205	42391655
Polyomavirus viraemia	42.98	16.46	22	24453	2090	42594770
Venoocclusive liver disease	42.39	16.46	40	24435	10262	42586598
Urine leukocyte esterase positive	42.03	16.46	14	24461	440	42596420
CD4 lymphocytes decreased	41.99	16.46	21	24454	1900	42594960
Human herpesvirus 6 infection reactivation	41.65	16.46	14	24461	453	42596407
Meningeal neoplasm	41.08	16.46	10	24465	96	42596764
Enterococcal infection	40.72	16.46	42	24433	11997	42584863
Toxicity to various agents	40.65	16.46	43	24432	229093	42367767
Myositis	40.04	16.46	46	24429	14820	42582040
Central nervous system lymphoma	38.95	16.46	18	24457	1367	42595493
Haematocrit decreased	38.89	16.46	71	24404	34837	42562023
Platelet count decreased	38.79	16.46	170	24305	138411	42458449
Completed suicide	38.42	16.46	5	24470	96460	42500400
Chronic lymphocytic leukaemia transformation	37.97	16.46	11	24464	215	42596645
Dizziness	37.65	16.46	53	24422	249201	42347659
Human polyomavirus infection	36.85	16.46	17	24458	1286	42595574
Nitrite urine present	36.83	16.46	11	24464	240	42596620
Parainfluenzae virus infection	36.66	16.46	24	24451	3619	42593241
Meningitis tuberculous	36.53	16.46	14	24461	665	42596195
Red cell distribution width increased	36.50	16.46	31	24444	6933	42589927
Hidradenocarcinoma	35.31	16.46	7	24468	22	42596838
Viraemia	34.76	16.46	18	24457	1752	42595108
Eosinophil percentage increased	34.61	16.46	13	24462	584	42596276
Anti-thyroid antibody positive	34.17	16.46	8	24467	64	42596796
Pulmonary haemorrhage	33.66	16.46	37	24438	11360	42585500
Varicella zoster virus infection	33.39	16.46	20	24455	2581	42594279
Nocardiosis	33.31	16.46	26	24449	5164	42591696
Chills	33.16	16.46	124	24351	93942	42502918
Hyperthyroidism	33.07	16.46	41	24434	14300	42582560
Mycobacterial infection	32.92	16.46	20	24455	2648	42594212
Atypical mycobacterial pneumonia	32.82	16.46	10	24465	234	42596626
Intracranial tumour haemorrhage	31.68	16.46	11	24464	393	42596467
Leukaemic infiltration	31.46	16.46	9	24466	168	42596692
Cystitis viral	31.41	16.46	15	24460	1227	42595633
Bilirubin urine present	31.31	16.46	9	24466	171	42596689
Rhabdomyolysis	31.17	16.46	4	24471	78015	42518845
Mean cell haemoglobin concentration decreased	31.12	16.46	16	24459	1534	42595326
Encephalitis	31.06	16.46	32	24443	9126	42587734
Bacteriuria	30.69	16.46	10	24465	293	42596567
Fall	30.55	16.46	55	24420	234465	42362395
Acute graft versus host disease in liver	30.30	16.46	17	24458	1941	42594919
Bacterial sepsis	30.23	16.46	27	24448	6455	42590405
Diarrhoea	29.18	16.46	151	24324	460698	42136162
Neutropenia	29.05	16.46	205	24270	199226	42397634
Autoimmune disorder	29.05	16.46	18	24457	2469	42594391
Herpes zoster meningoencephalitis	29.04	16.46	11	24464	506	42596354
Listeria sepsis	28.83	16.46	9	24466	229	42596631
Transplant dysfunction	28.80	16.46	20	24455	3323	42593537
Posterior reversible encephalopathy syndrome	28.52	16.46	36	24439	12785	42584075
Leukopenia	28.42	16.46	101	24374	74645	42522215
pH urine increased	28.41	16.46	7	24468	71	42596789
Thrombocytopenia	27.95	16.46	196	24279	190083	42406777
Petechiae	27.62	16.46	32	24443	10403	42586457
Device related infection	27.50	16.46	45	24430	20234	42576626
Reticulocyte count increased	27.37	16.46	12	24463	805	42596055
Bacterial test	27.35	16.46	8	24467	162	42596698
Myocardial infarction	27.16	16.46	19	24456	123990	42472870
Skin papilloma	27.13	16.46	18	24457	2776	42594084
Hepatosplenomegaly	27.03	16.46	22	24453	4638	42592222
Listeriosis	26.71	16.46	14	24461	1397	42595463
Drug hypersensitivity	26.40	16.46	12	24463	99377	42497483
Cytomegalovirus test positive	26.35	16.46	21	24454	4298	42592562
Band neutrophil percentage increased	26.21	16.46	7	24468	100	42596760
Retinitis	25.93	16.46	10	24465	483	42596377
Ophthalmoplegia	25.89	16.46	16	24459	2184	42594676
Central nervous system abscess	25.62	16.46	6	24469	48	42596812
Normocytic anaemia	25.33	16.46	19	24456	3558	42593302
Anogenital warts	25.29	16.46	11	24464	724	42596136
Neutrophil percentage decreased	25.12	16.46	9	24466	353	42596507
Graft versus host disease in lung	25.10	16.46	11	24464	737	42596123
Severe acute respiratory syndrome	24.81	16.46	7	24468	124	42596736
Papilloma	24.79	16.46	9	24466	367	42596493
White blood cell count decreased	24.72	16.46	127	24348	110269	42486591
Factor VIII deficiency	24.65	16.46	7	24468	127	42596733
Bone marrow transplant rejection	24.63	16.46	8	24467	232	42596628
Apoptosis	24.14	16.46	10	24465	583	42596277
Pneumonia fungal	24.12	16.46	28	24447	9118	42587742
Pneumonia necrotising	23.95	16.46	12	24463	1090	42595770
Confusional state	23.94	16.46	37	24438	167560	42429300
Dysgraphia	23.85	16.46	16	24459	2512	42594348
Cystitis haemorrhagic	23.76	16.46	25	24450	7304	42589556
Syncope	23.45	16.46	14	24461	99392	42497468
Blood urine present	23.06	16.46	31	24444	11702	42585158
Stem cell transplant	23.05	16.46	16	24459	2656	42594204
Klebsiella sepsis	22.89	16.46	16	24459	2685	42594175
Diarrhoea haemorrhagic	22.72	16.46	25	24450	7682	42589178
Interleukin-2 receptor increased	22.65	16.46	7	24468	172	42596688
Activated partial thromboplastin time shortened	22.44	16.46	9	24466	483	42596377
Constipation	22.08	16.46	37	24438	162254	42434606
Chronic lymphocytic leukaemia refractory	22.01	16.46	6	24469	93	42596767
Vasogenic cerebral oedema	21.69	16.46	11	24464	1025	42595835
Muscle spasticity	21.64	16.46	23	24452	6799	42590061
Candida infection	21.63	16.46	42	24433	21568	42575292
Autoimmune pancytopenia	21.55	16.46	6	24469	101	42596759
Staphylococcal scalded skin syndrome	21.45	16.46	8	24467	352	42596508
Haemorrhagic cyst	21.39	16.46	6	24469	104	42596756
Chronic obstructive pulmonary disease	21.36	16.46	5	24470	63109	42533751
Adenoviral hepatitis	21.32	16.46	9	24466	550	42596310
Mycobacterium kansasii infection	21.24	16.46	8	24467	362	42596498
Lymphadenopathy	21.14	16.46	54	24421	33311	42563549
Meningoencephalitis amoebic	20.78	16.46	7	24468	228	42596632
Pneumonia adenoviral	20.77	16.46	8	24467	385	42596475
Band sensation	20.68	16.46	6	24469	118	42596742
Disseminated blastomycosis	20.67	16.46	8	24467	390	42596470
Albuminuria	20.63	16.46	9	24466	597	42596263
Central nervous system lesion	20.60	16.46	24	24451	7846	42589014
Exophthalmos	20.60	16.46	10	24465	848	42596012
Pneumonia legionella	20.55	16.46	14	24461	2254	42594606
Incorrect dose administered	20.49	16.46	3	24472	52971	42543889
B-lymphocyte count decreased	20.48	16.46	10	24465	859	42596001
Stenotrophomonas infection	20.47	16.46	17	24458	3687	42593173
Oedema peripheral	20.45	16.46	29	24446	136047	42460813
Phaeohyphomycosis	20.30	16.46	11	24464	1173	42595687
Gastrointestinal haemorrhage	20.07	16.46	16	24459	97710	42499150
Joint swelling	20.05	16.46	7	24468	68015	42528845
Band neutrophil count increased	19.98	16.46	7	24468	257	42596603
Cerebrovascular accident	19.84	16.46	16	24459	97144	42499716
Hypogammaglobulinaemia	19.78	16.46	29	24446	11862	42584998
T-cell prolymphocytic leukaemia	19.76	16.46	5	24470	57	42596803
Meningitis listeria	19.73	16.46	9	24466	663	42596197
Tuberculosis liver	19.60	16.46	5	24470	59	42596801
Urinary sediment present	19.50	16.46	7	24468	276	42596584
Thyroid stimulating immunoglobulin	19.39	16.46	3	24472	0	42596860
Granulocyte percentage	19.39	16.46	3	24472	0	42596860
Respiratory failure	19.39	16.46	133	24342	127999	42468861
Monocyte count abnormal	19.09	16.46	5	24470	66	42596794
Haematocrit increased	18.99	16.46	14	24461	2553	42594307
Cardiac failure	18.98	16.46	20	24455	106836	42490024
Specific gravity urine decreased	18.88	16.46	5	24470	69	42596791
Glucose urine present	18.77	16.46	11	24464	1364	42595496
Complications of transplanted kidney	18.70	16.46	19	24456	5331	42591529
Coronary artery disease	18.69	16.46	4	24471	53716	42543144
Lymphocyte count abnormal	18.64	16.46	13	24462	2174	42594686
Enterococcal bacteraemia	18.51	16.46	14	24461	2653	42594207
Donor leukocyte infusion	18.50	16.46	5	24470	75	42596785
Thyroxine free increased	18.31	16.46	7	24468	330	42596530
Gastroenteritis astroviral	18.25	16.46	5	24470	79	42596781
Oral herpes	18.09	16.46	22	24453	7522	42589338
Human bocavirus infection	18.08	16.46	5	24470	82	42596778
Lymphoproliferative disorder	17.90	16.46	15	24460	3292	42593568
Electrocardiogram QT prolonged	17.89	16.46	3	24472	47942	42548918
Periorbital infection	17.88	16.46	6	24469	193	42596667
Staphylococcal sepsis	17.79	16.46	27	24448	11387	42585473
Plasma cell myeloma	17.71	16.46	3	24472	47575	42549285
Protein urine present	17.42	16.46	19	24456	5782	42591078
Aplasia pure red cell	17.35	16.46	21	24454	7145	42589715
Hepatitis infectious mononucleosis	17.34	16.46	5	24470	96	42596764
Dermatosis	17.18	16.46	7	24468	391	42596469
Thrombosis	17.09	16.46	9	24466	68502	42528358
Headache	16.99	16.46	211	24264	239158	42357702
Inappropriate schedule of product administration	16.97	16.46	18	24457	95884	42500976
Semenuria	16.87	16.46	4	24471	34	42596826
Lipaemic index score	16.87	16.46	4	24471	34	42596826
Varicella virus test positive	16.66	16.46	6	24469	239	42596621
Chronic lymphocytic leukaemia	16.60	16.46	17	24458	4812	42592048
Necrotising oesophagitis	16.59	16.46	9	24466	962	42595898
Paronychia	16.51	16.46	16	24459	4239	42592621

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Lymphocyte count decreased	1089.52	14.53	575	64848	56668	110467208
Cytomegalovirus infection	1050.69	14.53	552	64871	53892	110469984
Immune thrombocytopenia	1037.48	14.53	418	65005	22076	110501800
Urine abnormality	828.54	14.53	279	65144	8817	110515059
Adenovirus infection	665.57	14.53	249	65174	10745	110513131
Multiple sclerosis relapse	660.21	14.53	396	65027	49844	110474032
Post transplant lymphoproliferative disorder	620.82	14.53	261	65162	15352	110508524
Lymphopenia	567.96	14.53	332	65091	39838	110484038
Lymphocyte percentage decreased	543.99	14.53	178	65245	5132	110518744
Urine leukocyte esterase positive	542.58	14.53	164	65259	3622	110520254
White blood cells urine positive	516.71	14.53	187	65236	7337	110516539
Urinary sediment present	501.67	14.53	141	65282	2387	110521489
Red blood cells urine positive	495.81	14.53	165	65258	5020	110518856
Neutrophil percentage increased	476.41	14.53	158	65265	4755	110519121
Crystal urine present	469.80	14.53	127	65296	1847	110522029
Urine analysis abnormal	446.05	14.53	164	65259	6733	110517143
Blood urine present	403.57	14.53	223	65200	24022	110499854
Epstein-Barr virus infection	378.36	14.53	196	65227	18542	110505334
Cytomegalovirus infection reactivation	367.98	14.53	191	65232	18142	110505734
Graft versus host disease in skin	361.94	14.53	148	65275	8106	110515770
Autoimmune haemolytic anaemia	339.46	14.53	152	65271	10415	110513461
Graft versus host disease	335.20	14.53	181	65242	18625	110505251
Acute graft versus host disease in skin	333.92	14.53	151	65272	10589	110513287
Bacterial test positive	325.95	14.53	136	65287	7841	110516035
Herpes simplex	307.13	14.53	161	65262	15603	110508273
Autoimmune thyroiditis	304.93	14.53	122	65301	6312	110517564
Urine ketone body present	299.70	14.53	105	65318	3741	110520135
Bacterial test	294.73	14.53	79	65344	1110	110522766
Blood thyroid stimulating hormone decreased	291.03	14.53	122	65301	7117	110516759
Monocyte percentage increased	263.63	14.53	84	65339	2219	110521657
Nitrite urine present	259.29	14.53	72	65351	1163	110522713
Red cell distribution width increased	255.37	14.53	148	65275	17454	110506422
Transplant failure	253.77	14.53	103	65320	5532	110518344
BK virus infection	230.38	14.53	125	65298	12981	110510895
Flushing	221.49	14.53	291	65132	104445	110419431
Epstein-Barr virus infection reactivation	220.11	14.53	85	65338	3999	110519877
Pyrexia	219.66	14.53	1080	64343	897185	109626691
Blood thyroid stimulating hormone increased	207.03	14.53	114	65309	12187	110511689
Hyperthyroidism	206.64	14.53	157	65266	29104	110494772
Graft versus host disease in gastrointestinal tract	204.92	14.53	102	65321	8866	110515010
Haematocrit decreased	202.81	14.53	222	65201	65895	110457981
Cytomegalovirus viraemia	195.12	14.53	125	65298	17639	110506237
Transplant rejection	191.78	14.53	140	65283	24427	110499449
Haemoglobin urine present	189.55	14.53	53	65370	879	110522997
Microsporidia infection	183.51	14.53	57	65366	1382	110522494
Culture urine positive	176.76	14.53	76	65347	4720	110519156
Headache	175.83	14.53	1003	64420	881374	109642502
Mucosal inflammation	175.83	14.53	249	65174	95892	110427984
Product dose omission issue	175.18	14.53	3	65420	321779	110202097
Magnetic resonance imaging abnormal	173.85	14.53	71	65352	3874	110520002
Drug interaction	168.53	14.53	44	65379	500139	110023737
Progressive multifocal leukoencephalopathy	167.66	14.53	130	65293	24826	110499050
Specific gravity urine decreased	164.86	14.53	47	65376	839	110523037
Platelet count decreased	164.19	14.53	397	65026	230046	110293830
JC virus infection	163.24	14.53	74	65349	5216	110518660
White blood cell count decreased	162.17	14.53	394	65029	228996	110294880
Drug hypersensitivity	158.69	14.53	37	65386	454053	110069823
Drug intolerance	154.79	14.53	27	65396	406485	110117391
Protein urine present	154.58	14.53	92	65331	11392	110512484
Thrombotic microangiopathy	154.01	14.53	132	65291	29017	110494859
Leukocyturia	149.85	14.53	55	65368	2245	110521631
Endocrine ophthalmopathy	148.63	14.53	48	65375	1325	110522551
Acute graft versus host disease	147.34	14.53	93	65330	12788	110511088
Rheumatoid arthritis	144.68	14.53	8	65415	299605	110224271
Varicella zoster virus infection	141.28	14.53	71	65352	6297	110517579
Synovitis	139.94	14.53	5	65418	274087	110249789
Arthropathy	137.84	14.53	8	65415	287514	110236362
Thyroxine free increased	137.83	14.53	46	65377	1411	110522465
Herpes zoster	135.88	14.53	236	65187	108143	110415733
Chest discomfort	135.21	14.53	310	65113	173538	110350338
Joint swelling	132.87	14.53	48	65375	442797	110081079
Chronic graft versus host disease in skin	132.27	14.53	52	65371	2567	110521309
Systemic lupus erythematosus	132.12	14.53	4	65419	254334	110269542
Monocyte count decreased	125.61	14.53	56	65367	3795	110520081
Completed suicide	125.22	14.53	4	65419	242377	110281499
Anti-thyroid antibody positive	122.56	14.53	34	65389	547	110523329
Graft loss	121.95	14.53	41	65382	1287	110522589
CD4 lymphocytes decreased	119.13	14.53	50	65373	2924	110520952
Aplastic anaemia	118.19	14.53	105	65318	24203	110499673
Mean cell haemoglobin decreased	116.65	14.53	65	65358	7109	110516767
Specific gravity urine increased	116.34	14.53	32	65391	498	110523378
Overdose	113.62	14.53	6	65417	233788	110290088
Human herpesvirus 6 infection	113.53	14.53	62	65361	6519	110517357
Glossodynia	113.49	14.53	4	65419	222000	110301876
Epstein-Barr viraemia	113.40	14.53	51	65372	3528	110520348
Bradycardia	111.85	14.53	269	65154	155248	110368628
Neutrophil count increased	109.11	14.53	118	65305	34534	110489342
Chronic graft versus host disease in liver	107.06	14.53	34	65389	888	110522988
Multiple organ dysfunction syndrome	106.52	14.53	260	65163	151450	110372426
Drug monitoring procedure not performed	102.44	14.53	36	65387	1294	110522582
Pulmonary nocardiosis	101.31	14.53	43	65380	2586	110521290
End stage renal disease	100.93	14.53	91	65332	21382	110502494
Viraemia	100.70	14.53	49	65374	4053	110519823
Urinary casts	98.57	14.53	35	65388	1297	110522579
Chronic graft versus host disease	97.59	14.53	64	65359	9393	110514483
Wound	97.44	14.53	12	65411	234425	110289451
Eosinophil percentage increased	96.34	14.53	36	65387	1546	110522330
Acute graft versus host disease in intestine	94.17	14.53	52	65371	5587	110518289
Leukopenia	92.99	14.53	244	65179	148547	110375329
Drug abuse	91.37	14.53	3	65420	177408	110346468
Swelling	91.04	14.53	47	65376	350994	110172882
Maternal exposure during pregnancy	90.51	14.53	20	65403	254863	110269013
Impaired healing	89.79	14.53	7	65416	196710	110327166
Chills	89.50	14.53	282	65141	190298	110333578
pH urine increased	88.67	14.53	25	65398	428	110523448
Death	87.56	14.53	176	65247	698693	109825183
Confusional state	87.40	14.53	89	65334	468591	110055285
Body temperature increased	87.40	14.53	133	65290	54580	110469296
Polyomavirus viraemia	86.79	14.53	42	65381	3432	110520444
Bilirubin urine present	86.34	14.53	23	65400	315	110523561
Infusion site pain	86.20	14.53	76	65347	17343	110506533
Diffuse large B-cell lymphoma	86.03	14.53	73	65350	15825	110508051
Red blood cell count decreased	85.82	14.53	146	65277	65777	110458099
Autoimmune neutropenia	85.80	14.53	27	65396	684	110523192
Osteoarthritis	84.77	14.53	6	65417	182617	110341259
Monocyte count increased	84.43	14.53	67	65356	13226	110510650
Urinary tract infection bacterial	84.24	14.53	55	65368	8012	110515864
Urobilinogen urine increased	83.91	14.53	26	65397	625	110523251
Arthralgia	83.36	14.53	214	65209	779418	109744458
Red blood cells urine	83.25	14.53	26	65397	642	110523234
Hepatic enzyme increased	83.15	14.53	43	65380	320849	110203027
Mean cell haemoglobin concentration decreased	83.00	14.53	48	65375	5634	110518242
Toxicity to various agents	82.18	14.53	98	65325	480457	110043419
Injury	81.78	14.53	6	65417	177259	110346617
Type 2 diabetes mellitus	81.76	14.53	6	65417	177226	110346650
Feeling hot	81.60	14.53	172	65251	90934	110432942
Red blood cell count increased	81.17	14.53	45	65378	4873	110519003
Multiple sclerosis	80.01	14.53	87	65336	25611	110498265
Pain	79.48	14.53	294	65129	954661	109569215
Diarrhoea	79.29	14.53	376	65047	1139129	109384747
Heavy menstrual bleeding	78.19	14.53	70	65353	16295	110507581
Haemolytic anaemia	78.00	14.53	78	65345	20842	110503034
Petechiae	77.99	14.53	82	65341	23235	110500641
Mucoepidermoid carcinoma of salivary gland	77.96	14.53	18	65405	130	110523746
Red cell distribution width decreased	77.64	14.53	34	65389	2207	110521669
Irritable bowel syndrome	77.38	14.53	5	65418	164210	110359666
Tachycardia	75.90	14.53	300	65123	226345	110297531
Bronchopulmonary aspergillosis	75.87	14.53	91	65332	29772	110494104
Mean cell volume decreased	74.97	14.53	45	65378	5657	110518219
Band sensation	74.78	14.53	27	65396	1051	110522825
Pseudomonas infection	74.28	14.53	87	65336	27766	110496110
Blood thyroid stimulating hormone abnormal	73.56	14.53	27	65396	1102	110522774
Autoimmune thyroid disorder	73.43	14.53	15	65408	55	110523821
Band neutrophil percentage increased	73.23	14.53	21	65402	383	110523493
Cells in urine	72.30	14.53	18	65405	185	110523691
Lymphocyte count abnormal	71.91	14.53	33	65390	2393	110521483
Aspergillus infection	71.64	14.53	82	65341	25534	110498342
Alopecia	70.59	14.53	67	65356	364686	110159190
Hypersensitivity	70.55	14.53	81	65342	403917	110119959
Eosinophil count increased	70.34	14.53	74	65349	20984	110502892
Chronic graft versus host disease in intestine	70.14	14.53	23	65400	667	110523209
Injection site pain	69.48	14.53	11	65412	177911	110345965
Folliculitis	68.65	14.53	9	65414	167644	110356232
Urinary tract infection	67.99	14.53	376	65047	325906	110197970
Listeriosis	67.24	14.53	33	65390	2781	110521095
Bacteriuria	67.21	14.53	27	65396	1411	110522465
Poor quality sleep	67.18	14.53	83	65340	27994	110495882
Urine leukocyte esterase	66.91	14.53	17	65406	191	110523685
Pneumonia cytomegaloviral	66.78	14.53	45	65378	6909	110516967
Fall	65.72	14.53	164	65259	603318	109920558
Venoocclusive disease	65.59	14.53	43	65380	6307	110517569
Thyroid stimulating immunoglobulin	65.53	14.53	14	65409	67	110523809
Peripheral swelling	65.29	14.53	86	65337	403948	110119928
Pericarditis	65.23	14.53	24	65399	219090	110304786
Pulmonary haemorrhage	64.40	14.53	63	65360	16393	110507483
Central nervous system lesion	63.61	14.53	61	65362	15492	110508384
CD4 lymphocytes abnormal	63.31	14.53	14	65409	81	110523795
Haemophagocytic lymphohistiocytosis	62.54	14.53	85	65338	31474	110492402
Menstruation irregular	61.70	14.53	40	65383	5757	110518119
Venoocclusive liver disease	60.98	14.53	59	65364	15148	110508728
Hypothyroidism	59.98	14.53	133	65290	72766	110451110
Human herpesvirus 6 infection reactivation	59.07	14.53	23	65400	1106	110522770
Tri-iodothyronine free increased	58.11	14.53	16	65407	250	110523626
Blood creatinine decreased	57.92	14.53	46	65377	9091	110514785
Cystitis haemorrhagic	57.89	14.53	52	65371	12157	110511719
Arthritis	57.79	14.53	14	65409	167572	110356304
Band neutrophil count increased	57.55	14.53	20	65403	695	110523181
Gastrointestinal disorder	57.53	14.53	36	65387	241916	110281960
Thyroxine free decreased	57.34	14.53	23	65400	1197	110522679
Idiopathic pneumonia syndrome	57.01	14.53	21	65402	866	110523010
Oropharyngeal pain	56.15	14.53	192	65231	135084	110388792
Thyroid function test abnormal	56.09	14.53	31	65392	3336	110520540
Polymyositis	55.97	14.53	32	65391	3676	110520200
Optic neuritis	55.88	14.53	49	65374	11098	110512778
Viral haemorrhagic cystitis	55.82	14.53	31	65392	3368	110520508
Rhabdomyolysis	55.74	14.53	4	65419	120397	110403479
Epstein-Barr virus associated lymphoproliferative disorder	55.74	14.53	35	65388	4767	110519109
Stomatitis	55.43	14.53	47	65376	270195	110253681
Posterior reversible encephalopathy syndrome	55.05	14.53	83	65340	33778	110490098
Therapeutic product effect incomplete	55.03	14.53	32	65391	223773	110300103
Pyelonephritis fungal	54.89	14.53	16	65407	310	110523566
Haemoglobin decreased	54.74	14.53	291	65132	248436	110275440
Asthma	54.51	14.53	41	65382	250250	110273626
Bronchiolitis obliterans syndrome	54.38	14.53	19	65404	671	110523205
Oedema peripheral	54.07	14.53	69	65354	328591	110195285
Sleep disorder	53.89	14.53	25	65398	198619	110325257
Lymphoproliferative disorder	53.77	14.53	40	65383	7178	110516698
Tri-iodothyronine free decreased	53.60	14.53	17	65406	442	110523434
Muscular weakness	53.53	14.53	289	65134	248179	110275697
C-reactive protein abnormal	53.00	14.53	7	65416	129688	110394188
Liver injury	52.99	14.53	12	65411	150401	110373475
Mean cell haemoglobin concentration increased	52.63	14.53	21	65402	1078	110522798
Meningitis listeria	52.60	14.53	22	65401	1275	110522601
Discomfort	52.37	14.53	31	65392	214676	110309200
White blood cells urine	52.04	14.53	17	65406	487	110523389
Feeling cold	52.00	14.53	81	65342	33906	110489970
Propionibacterium infection	51.93	14.53	15	65408	281	110523595
Toxoplasmosis	51.71	14.53	29	65394	3210	110520666
Lactobacillus infection	51.52	14.53	17	65406	503	110523373
Neutropenia	51.13	14.53	388	65035	374232	110149644
Meningitis viral	51.03	14.53	26	65397	2373	110521503
Myocardial infarction	50.84	14.53	25	65398	192058	110331818
Hypoglycaemia	50.62	14.53	5	65418	116099	110407777
Bacterial sepsis	50.61	14.53	45	65378	10381	110513495
Medication error	50.26	14.53	3	65420	105363	110418513
Gastroenteritis adenovirus	50.19	14.53	16	65407	423	110523453
Monocyte percentage decreased	50.14	14.53	15	65408	319	110523557
Blister	49.83	14.53	37	65386	227339	110296537
Musculoskeletal pain	49.70	14.53	23	65400	183000	110340876
Atrial fibrillation	49.52	14.53	38	65385	229604	110294272
Joint range of motion decreased	48.78	14.53	7	65416	121825	110402051
Gastroenteritis norovirus	48.78	14.53	29	65394	3582	110520294
Acanthamoeba infection	48.50	14.53	17	65406	606	110523270
Menstrual disorder	48.45	14.53	32	65391	4752	110519124
T-lymphocyte count decreased	48.42	14.53	17	65406	609	110523267
Eosinophil percentage decreased	48.31	14.53	15	65408	363	110523513
Psoriasis	47.68	14.53	12	65411	139981	110383895
Blood cholesterol increased	47.49	14.53	25	65398	184760	110339116
Platelet count abnormal	47.22	14.53	35	65388	6247	110517629
Mycobacterium kansasii infection	47.11	14.53	15	65408	395	110523481
Cystitis viral	46.70	14.53	21	65402	1452	110522424
Product use issue	46.69	14.53	70	65353	311625	110212251
Urine oxalate increased	46.52	14.53	13	65410	215	110523661
Exophthalmos	46.51	14.53	24	65399	2249	110521627
Acute disseminated encephalomyelitis	46.41	14.53	15	65408	415	110523461
Acute myeloid leukaemia recurrent	46.37	14.53	32	65391	5107	110518769
Parainfluenzae virus infection	46.12	14.53	36	65387	6938	110516938
Bone marrow transplant rejection	46.06	14.53	14	65409	315	110523561
Staphylococcal infection	46.04	14.53	117	65306	69827	110454049
Human polyomavirus infection	45.67	14.53	22	65401	1780	110522096
Adenovirus reactivation	45.65	14.53	17	65406	723	110523153
Myelocyte count increased	45.64	14.53	18	65405	896	110522980
Pulmonary fibrosis	45.53	14.53	4	65419	102038	110421838
Lymphadenopathy	45.41	14.53	110	65313	63725	110460151
Central nervous system lymphoma	45.22	14.53	26	65397	3018	110520858
Haematocrit increased	45.03	14.53	31	65392	4928	110518948
Dry mouth	44.51	14.53	32	65391	199916	110323960
Epstein-Barr virus associated lymphoma	44.18	14.53	21	65402	1649	110522227
Granulocyte percentage	44.09	14.53	10	65413	66	110523810
Nocardiosis	43.87	14.53	36	65387	7450	110516426
Autoimmune hypothyroidism	43.87	14.53	15	65408	496	110523380
Lipaemic index score	43.76	14.53	11	65412	118	110523758
Thrombocytopenia	43.55	14.53	354	65069	348531	110175345
Hyponatraemia	43.24	14.53	39	65384	217614	110306262
Decreased appetite	43.17	14.53	141	65282	475705	110048171
Intentional product use issue	42.93	14.53	50	65373	247856	110276020
Abdominal discomfort	42.85	14.53	107	65316	393751	110130125
Pancytopenia	42.59	14.53	240	65183	209373	110314503
Oedema	42.47	14.53	37	65386	209939	110313937
Autoimmune pancytopenia	42.42	14.53	12	65411	208	110523668
Adverse drug reaction	42.42	14.53	6	65417	105553	110418323
Urine bilirubin decreased	42.33	14.53	11	65412	136	110523740
Enterococcal infection	42.10	14.53	56	65367	20310	110503566
Hepatitis infectious mononucleosis	42.10	14.53	12	65411	214	110523662
Expanded disability status scale score increased	42.09	14.53	17	65406	901	110522975
Obesity	42.08	14.53	8	65415	113343	110410533
Chronic obstructive pulmonary disease	42.05	14.53	7	65416	109151	110414725
Infusion related reaction	41.90	14.53	103	65320	381059	110142817
Pathogen resistance	41.89	14.53	52	65371	17620	110506256
Neutrophil percentage decreased	41.65	14.53	17	65406	926	110522950
Mean cell haemoglobin increased	41.56	14.53	31	65392	5586	110518290
Myelocyte percentage increased	41.54	14.53	12	65411	225	110523651
Drug-induced liver injury	41.45	14.53	10	65413	120057	110403819
Rectal haemorrhage	41.33	14.53	10	65413	119823	110404053
B-cell lymphoma	41.08	14.53	34	65389	7120	110516756
Infusion site extravasation	40.86	14.53	42	65381	11592	110512284
Encephalitis	40.80	14.53	53	65370	18786	110505090
Creatinine urine decreased	40.31	14.53	13	65410	357	110523519
Gingival bleeding	40.17	14.53	54	65369	19785	110504091
Wrong technique in product usage process	40.15	14.53	3	65420	87345	110436531
Acute graft versus host disease in liver	40.07	14.53	22	65401	2337	110521539
Systemic mycosis	39.72	14.53	26	65397	3803	110520073
Adverse event	39.71	14.53	8	65415	108801	110415075
Herpes zoster infection neurological	39.66	14.53	14	65409	510	110523366
Leukaemia recurrent	39.34	14.53	24	65399	3107	110520769
Heart rate increased	39.28	14.53	179	65244	143655	110380221
Thrombotic thrombocytopenic purpura	39.19	14.53	33	65390	7078	110516798
Suicide attempt	39.02	14.53	7	65416	103387	110420489
Product use in unapproved indication	37.88	14.53	418	65005	446959	110076917
Sciatica	37.72	14.53	5	65418	92394	110431482
Vitiligo	37.58	14.53	23	65400	2994	110520882
Cytomegalovirus test positive	37.44	14.53	32	65391	7004	110516872
Weight increased	36.92	14.53	126	65297	419518	110104358
Hypercholesterolaemia	36.88	14.53	5	65418	90832	110433044
Listeria sepsis	36.85	14.53	15	65408	811	110523065
Monocyte count abnormal	35.72	14.53	11	65412	259	110523617
Immune reconstitution inflammatory syndrome	35.69	14.53	46	65377	16180	110507696
Mean platelet volume decreased	35.69	14.53	23	65400	3277	110520599
Varicella	35.34	14.53	24	65399	3731	110520145
Rotavirus infection	35.18	14.53	15	65408	912	110522964
Hidradenocarcinoma	35.10	14.53	7	65416	22	110523854
Delirium	35.09	14.53	18	65405	135007	110388869
Incorrect dose administered	35.07	14.53	9	65414	103632	110420244
Chronic lymphocytic leukaemia transformation	34.83	14.53	11	65412	282	110523594
Drug ineffective	34.68	14.53	663	64760	1519877	109003999
Staphylococcal bacteraemia	34.67	14.53	46	65377	16642	110507234
Oral herpes	34.50	14.53	70	65353	36010	110487866
Proteinuria	34.03	14.53	74	65349	39944	110483932
Actinomycotic sepsis	34.01	14.53	10	65413	200	110523676
General physical health deterioration	33.92	14.53	133	65290	425162	110098714
Vomiting	33.86	14.53	360	65063	910315	109613561
Anaemia	33.67	14.53	188	65235	546898	109976978
Lower limb fracture	33.49	14.53	3	65420	75345	110448531
Loss of personal independence in daily activities	33.40	14.53	24	65399	149996	110373880
Neutrophil count decreased	33.38	14.53	151	65272	120790	110403086
Candida infection	33.37	14.53	82	65341	47927	110475949
Road traffic accident	33.27	14.53	11	65412	107387	110416489
Exposure during pregnancy	33.25	14.53	30	65393	167394	110356482
Listeria test positive	33.11	14.53	6	65417	9	110523867
Cerebrovascular accident	33.09	14.53	35	65388	181249	110342627
Herpes zoster meningoencephalitis	33.01	14.53	15	65408	1063	110522813
Limb discomfort	32.99	14.53	74	65349	40780	110483096
Immature granulocyte count increased	32.97	14.53	14	65409	843	110523033
Factor VIII deficiency	32.90	14.53	9	65414	137	110523739
Crystalluria	32.70	14.53	16	65407	1339	110522537
Blood pressure systolic increased	32.69	14.53	5	65418	82986	110440890
Encephalitis viral	32.62	14.53	21	65402	2986	110520890
Lung disorder	32.60	14.53	35	65388	180012	110343864
Thyroid disorder	32.56	14.53	45	65378	16924	110506952
Glucose urine present	32.54	14.53	19	65404	2270	110521606
Drug exposure before pregnancy	32.42	14.53	13	65410	676	110523200
Anogenital warts	32.26	14.53	15	65408	1121	110522755
Drug reaction with eosinophilia and systemic symptoms	32.21	14.53	5	65418	82090	110441786
Basophil percentage increased	32.13	14.53	10	65413	244	110523632
Colitis ulcerative	32.03	14.53	4	65419	77359	110446517
B-lymphocyte count decreased	31.73	14.53	18	65405	2037	110521839
Pneumonia legionella	31.68	14.53	22	65401	3547	110520329
Normocytic anaemia	31.56	14.53	28	65395	6439	110517437
Pneumonia necrotising	31.39	14.53	17	65406	1758	110522118
Infection reactivation	31.26	14.53	23	65400	4058	110519818
Mean cell volume increased	30.94	14.53	31	65392	8299	110515577
Post procedural hypothyroidism	30.89	14.53	10	65413	278	110523598
Pneumocystis jirovecii pneumonia	30.78	14.53	74	65349	42661	110481215
Drug resistance	30.76	14.53	88	65335	56286	110467590
Red blood cell elliptocytes present	30.75	14.53	9	65414	177	110523699
Diplopia	30.66	14.53	73	65350	41821	110482055
Depressed level of consciousness	30.65	14.53	14	65409	112264	110411612
Goitre	30.56	14.53	27	65396	6177	110517699
Growth retardation	30.43	14.53	19	65404	2563	110521313
International normalised ratio increased	30.40	14.53	7	65416	86765	110437111
Treatment failure	30.39	14.53	75	65348	277159	110246717
Leukaemic infiltration	30.37	14.53	9	65414	185	110523691
Sedation	30.37	14.53	3	65420	69680	110454196
Mean platelet volume increased	30.15	14.53	16	65407	1588	110522288
Reticulocyte count increased	30.13	14.53	16	65407	1590	110522286
Neuropathy peripheral	30.13	14.53	37	65386	179240	110344636
Pregnancy of partner	30.11	14.53	10	65413	302	110523574
Herpes virus infection	30.00	14.53	31	65392	8607	110515269
Intentional product misuse	29.93	14.53	21	65402	132883	110390993
CD4 lymphocyte percentage decreased	29.81	14.53	6	65417	20	110523856
Lower respiratory tract infection	29.70	14.53	62	65361	243044	110280832
Citrobacter infection	29.67	14.53	15	65408	1347	110522529
Injection site reaction	29.63	14.53	8	65415	89062	110434814
Cellulitis staphylococcal	29.25	14.53	15	65408	1388	110522488
Pollakiuria	29.15	14.53	74	65349	44121	110479755
Coronary artery disease	28.98	14.53	4	65419	71686	110452190
Musculoskeletal stiffness	28.90	14.53	78	65345	279744	110244132
Liver disorder	28.83	14.53	25	65398	142218	110381658
Chronic hepatitis C	28.80	14.53	12	65411	689	110523187
T-cell prolymphocytic leukaemia	28.66	14.53	7	65416	66	110523810
Injection site erythema	28.55	14.53	10	65413	94166	110429710
Creatinine urine increased	28.53	14.53	11	65412	515	110523361
Orthostatic hypotension	28.49	14.53	3	65420	66246	110457630
Papilloma viral infection	28.44	14.53	17	65406	2121	110521755
Urticaria	28.39	14.53	301	65122	318556	110205320
Delayed graft function	28.21	14.53	22	65401	4235	110519641
B-lymphocyte count increased	28.15	14.53	8	65415	141	110523735
White blood cell count abnormal	28.07	14.53	27	65396	6882	110516994
Eye infection toxoplasmal	27.86	14.53	12	65411	748	110523128
Vulvovaginal mycotic infection	27.69	14.53	24	65399	5353	110518523
Meningitis tuberculous	27.62	14.53	14	65409	1264	110522612
Graft versus host disease in lung	27.62	14.53	14	65409	1264	110522612
Immature granulocyte percentage increased	27.60	14.53	7	65416	78	110523798
Infertility	27.53	14.53	12	65411	770	110523106
Angioedema	27.33	14.53	12	65411	98488	110425388
Malignant neoplasm progression	27.31	14.53	38	65385	174529	110349347
Enterococcal bacteraemia	27.30	14.53	22	65401	4439	110519437
Anaphylactic reaction	27.17	14.53	17	65406	114283	110409593
Periportal oedema	27.07	14.53	8	65415	163	110523713
Cardiac disorder	27.03	14.53	6	65417	76274	110447602
Fungal skin infection	26.97	14.53	27	65396	7222	110516654
Fusarium infection	26.77	14.53	18	65405	2753	110521123
Thyroid stimulating immunoglobulin increased	26.70	14.53	8	65415	171	110523705
Pneumonia adenoviral	26.44	14.53	11	65412	629	110523247
Acute kidney injury	26.16	14.53	245	65178	635185	109888691
Disseminated blastomycosis	25.80	14.53	10	65413	475	110523401
Anti-glomerular basement membrane antibody	25.73	14.53	4	65419	0	110523876
Goodpasture's syndrome	25.73	14.53	4	65419	0	110523876
Aplasia pure red cell	25.67	14.53	30	65393	9548	110514328
Basophil count increased	25.67	14.53	15	65408	1795	110522081
Thyroiditis	25.41	14.53	25	65398	6548	110517328
Hypokalaemia	25.39	14.53	43	65380	182405	110341471
Mycobacterial infection	25.38	14.53	21	65402	4396	110519480
Legionella infection	25.23	14.53	12	65411	944	110522932
Acute myocardial infarction	25.22	14.53	9	65414	83768	110440108
Central nervous system abscess	25.12	14.53	6	65417	51	110523825
Apoptosis	25.10	14.53	11	65412	715	110523161
Embryonal rhabdomyosarcoma	25.02	14.53	6	65417	52	110523824
Respiratory failure	24.98	14.53	215	65208	215117	110308759
Cytomegalovirus oesophagitis	24.87	14.53	12	65411	974	110522902
Electrocardiogram QT prolonged	24.82	14.53	17	65406	108943	110414933
Infection in an immunocompromised host	24.80	14.53	15	65408	1912	110521964
Parotitis	24.67	14.53	18	65405	3135	110520741
Aggression	24.66	14.53	3	65420	59207	110464669
Cardiac failure	24.51	14.53	46	65377	187580	110336296
Meningism	24.50	14.53	11	65412	758	110523118
Syncope	24.45	14.53	52	65371	202484	110321392
Plasma cell myeloma	24.32	14.53	4	65419	62932	110460944
Wheezing	24.26	14.53	74	65349	255156	110268720
Urine bilirubin increased	24.24	14.53	7	65416	131	110523745
Dysgraphia	24.22	14.53	21	65402	4684	110519192
Quadriparesis	24.22	14.53	21	65402	4686	110519190
Cardiac arrest	24.18	14.53	50	65373	196703	110327173
Activated partial thromboplastin time shortened	24.08	14.53	12	65411	1045	110522831
Insomnia	24.00	14.53	322	65101	360268	110163608
Inappropriate schedule of product administration	23.99	14.53	53	65370	203584	110320292
Nail disorder	23.97	14.53	3	65420	57932	110465944
Varicella virus test positive	23.94	14.53	9	65414	393	110523483
Hyperkalaemia	23.92	14.53	27	65396	135769	110388107
Eosinophil count abnormal	23.90	14.53	12	65411	1062	110522814
Graft versus host disease in liver	23.79	14.53	16	65407	2449	110521427
Pneumonia fungal	23.74	14.53	36	65387	14718	110509158
Constipation	23.63	14.53	120	65303	357666	110166210
Myositis	23.62	14.53	55	65368	31061	110492815
Condition aggravated	23.58	14.53	300	65123	734536	109789340
Chromaturia	23.51	14.53	53	65370	29307	110494569
Anti-glomerular basement membrane antibody positive	23.50	14.53	4	65419	3	110523873
Metabolic acidosis	23.48	14.53	15	65408	99729	110424147
Hypocalcaemia	23.45	14.53	5	65418	65361	110458515
Fibrin D dimer increased	23.38	14.53	29	65394	9816	110514060
Growth failure	23.33	14.53	8	65415	267	110523609
Haemoglobin urine	23.26	14.53	7	65416	152	110523724
Throat irritation	23.08	14.53	77	65346	53475	110470401
Gastrointestinal haemorrhage	23.04	14.53	39	65384	165479	110358397
Hypomagnesaemia	22.97	14.53	4	65419	60366	110463510
Anti-glomerular basement membrane disease	22.88	14.53	7	65416	161	110523715
Complications of bone marrow transplant	22.85	14.53	10	65413	648	110523228
Ophthalmoplegia	22.77	14.53	18	65405	3532	110520344
Fungal infection	22.75	14.53	74	65349	50732	110473144
Transient ischaemic attack	22.74	14.53	5	65418	63977	110459899
Temperature intolerance	22.40	14.53	34	65389	13916	110509960
Parvovirus infection	22.27	14.53	11	65412	940	110522936
Haemoglobin increased	21.81	14.53	27	65396	9120	110514756
Feeling abnormal	21.78	14.53	182	65241	180529	110343347
Anti-thyroid antibody	21.67	14.53	5	65418	36	110523840
Tuberculosis liver	21.54	14.53	6	65417	98	110523778
Papilloma	21.35	14.53	9	65414	532	110523344
Evans syndrome	21.32	14.53	10	65413	762	110523114
Lymphocyte percentage abnormal	21.10	14.53	5	65418	41	110523835
Retinal depigmentation	21.09	14.53	8	65415	358	110523518
Sinusitis	21.04	14.53	97	65326	296591	110227285
Skin papilloma	20.86	14.53	23	65400	6873	110517003
Acute respiratory distress syndrome	20.76	14.53	74	65349	53124	110470752
Accidental overdose	20.70	14.53	3	65420	51831	110472045
Engraft failure	20.68	14.53	10	65413	816	110523060
Dehydration	20.65	14.53	90	65333	279421	110244455
Acquired haemophilia	20.54	14.53	15	65408	2616	110521260
Splenomegaly	20.49	14.53	45	65378	24453	110499423
Laboratory test abnormal	20.46	14.53	65	65358	44014	110479862
Product prescribing error	20.43	14.53	3	65420	51328	110472548
Donor leukocyte infusion	20.39	14.53	5	65418	48	110523828
Infusion site discomfort	20.35	14.53	13	65410	1824	110522052
Meningoencephalitis amoebic	20.32	14.53	7	65416	237	110523639
Stenotrophomonas infection	20.30	14.53	21	65402	5837	110518039
Chronic lymphocytic leukaemia refractory	20.22	14.53	6	65417	124	110523752
Malaise	20.19	14.53	278	65145	671541	109852335
Bacteraemia	20.12	14.53	63	65360	42327	110481549
Severe acute respiratory syndrome	20.12	14.53	7	65416	244	110523632
Sinus bradycardia	20.11	14.53	50	65373	29433	110494443
Treatment noncompliance	20.08	14.53	9	65414	72981	110450895
Tri-iodothyronine free abnormal	20.03	14.53	5	65418	52	110523824
Eosinophil count decreased	19.83	14.53	21	65402	5997	110517879
Fumbling	19.82	14.53	6	65417	133	110523743
Protein urine	19.73	14.53	12	65411	1544	110522332
Infusion site scar	19.73	14.53	8	65415	428	110523448
Focal nodular hyperplasia	19.73	14.53	10	65413	903	110522973
Familial haemophagocytic lymphohistiocytosis	19.69	14.53	5	65418	56	110523820
Gait disturbance	19.57	14.53	251	65172	277957	110245919
Diarrhoea haemorrhagic	19.51	14.53	34	65389	15605	110508271
Diabetes mellitus	19.50	14.53	18	65405	99363	110424513
Altered state of consciousness	19.50	14.53	5	65418	57621	110466255
Vaccination site inflammation	19.45	14.53	5	65418	59	110523817
Granulocyte count increased	19.44	14.53	13	65410	1970	110521906
Platelet count increased	19.39	14.53	46	65377	26288	110497588
Hot flush	19.39	14.53	84	65339	65952	110457924
Loefgren syndrome	19.37	14.53	6	65417	144	110523732
Glomerulonephritis membranous	19.32	14.53	13	65410	1990	110521886
Urobilinogen urine	19.31	14.53	4	65419	16	110523860
Cytomegalovirus gastritis	19.27	14.53	9	65414	679	110523197
Papillary thyroid cancer	19.27	14.53	15	65408	2879	110520997
Histoplasmosis disseminated	19.27	14.53	17	65406	3882	110519994
Pneumonia pseudomonal	19.17	14.53	23	65400	7523	110516353
Pulmonary alveolar haemorrhage	19.15	14.53	39	65384	20111	110503765
Organising pneumonia	19.13	14.53	32	65391	14211	110509665
Platelet morphology abnormal	19.07	14.53	6	65417	152	110523724
Glomerulonephritis chronic	19.06	14.53	7	65416	286	110523590
Thyroid cyst	18.96	14.53	8	65415	474	110523402
Foot deformity	18.91	14.53	3	65420	48477	110475399
Blood stem cell transplant failure	18.91	14.53	9	65414	709	110523167
Malignant melanoma	18.87	14.53	35	65388	16856	110507020
Haematuria	18.84	14.53	98	65325	82907	110440969
Albuminuria	18.77	14.53	10	65413	1001	110522875
Adenoviral hepatitis	18.76	14.53	10	65413	1002	110522874
Paternal exposure timing unspecified	18.73	14.53	5	65418	69	110523807
Gastrooesophageal reflux disease	18.70	14.53	50	65373	179926	110343950
Urine uric acid increased	18.67	14.53	5	65418	70	110523806
Blood creatine phosphokinase increased	18.60	14.53	10	65413	73067	110450809
Cytomegalovirus chorioretinitis	18.56	14.53	22	65401	7106	110516770
Periorbital infection	18.50	14.53	6	65417	168	110523708
Pneumonia	18.47	14.53	387	65036	876327	109647549
Pulmonary embolism	18.43	14.53	65	65358	214409	110309467
Chronic lymphocytic leukaemia recurrent	18.42	14.53	10	65413	1039	110522837
Oesophageal candidiasis	18.36	14.53	28	65395	11506	110512370
Klebsiella sepsis	18.34	14.53	17	65406	4136	110519740
Cardio-respiratory arrest	18.33	14.53	25	65398	115811	110408065
Ill-defined disorder	18.32	14.53	41	65382	156812	110367064
Heart rate decreased	18.30	14.53	97	65326	82659	110441217
Nystagmus	18.28	14.53	28	65395	11549	110512327
Interleukin-2 receptor increased	18.21	14.53	7	65416	325	110523551
Atypical mycobacterial pneumonia	18.21	14.53	7	65416	325	110523551
Erythema	18.06	14.53	257	65166	291190	110232686
Odynophagia	18.04	14.53	31	65392	14070	110509806
Injection site swelling	17.99	14.53	7	65416	61783	110462093
Lactic acidosis	17.99	14.53	17	65406	92794	110431082
Nitrite urine	17.96	14.53	4	65419	24	110523852
Eyelid retraction	17.93	14.53	5	65418	82	110523794
Urine odour abnormal	17.86	14.53	22	65401	7393	110516483
Pneumonitis	17.82	14.53	91	65332	76440	110447436
Cervical dysplasia	17.81	14.53	14	65409	2726	110521150
Weight decreased	17.76	14.53	184	65239	467873	110056003
Obstructive airways disorder	17.68	14.53	3	65420	46146	110477730
Inflammation	17.67	14.53	57	65366	193181	110330695
Thrombosis	17.66	14.53	23	65400	108639	110415237
Enterobacter bacteraemia	17.65	14.53	11	65412	1479	110522397
Gastroenteritis astroviral	17.56	14.53	6	65417	198	110523678
Post herpetic neuralgia	17.54	14.53	15	65408	3286	110520590
Glomerulonephropathy	17.53	14.53	7	65416	360	110523516
Lymphocyte percentage increased	17.51	14.53	9	65414	837	110523039
Bladder dysfunction	17.50	14.53	11	65412	1501	110522375
Stem cell transplant	17.42	14.53	17	65406	4410	110519466
Liver function test increased	17.42	14.53	16	65407	88532	110435344
Transplant dysfunction	17.37	14.53	23	65400	8305	110515571
Pancreas transplant rejection	17.37	14.53	7	65416	369	110523507
Gait inability	17.32	14.53	34	65389	136342	110387534
Thyroid hormones increased	17.28	14.53	8	65415	592	110523284
Monocyte percentage abnormal	17.22	14.53	3	65420	3	110523873
Gastroenteritis rotavirus	17.18	14.53	8	65415	600	110523276
Alopecia universalis	17.08	14.53	7	65416	385	110523491
Skin exfoliation	17.05	14.53	16	65407	87635	110436241
Paraparesis	16.98	14.53	17	65406	4549	110519327
Poikilocytosis	16.91	14.53	7	65416	395	110523481
Osteoporosis	16.85	14.53	16	65407	87136	110436740
Bronchitis	16.79	14.53	43	65380	156989	110366887
Urinary incontinence	16.79	14.53	65	65358	48522	110475354
Disorder of globe	16.76	14.53	3	65420	4	110523872
Semenuria	16.75	14.53	4	65419	34	110523842
Basophil count abnormal	16.75	14.53	4	65419	34	110523842
Off label use	16.74	14.53	1064	64359	1499121	109024755
Sepsis	16.58	14.53	279	65144	327067	110196809
Endometrial ablation	16.54	14.53	9	65414	939	110522937
Chronic lymphocytic leukaemia	16.51	14.53	19	65404	5949	110517927
Injection site pruritus	16.32	14.53	5	65418	51253	110472623
Mycobacterium abscessus infection	16.29	14.53	11	65412	1695	110522181
Neutrophil percentage abnormal	16.26	14.53	4	65419	39	110523837
Epstein-Barr virus test positive	16.24	14.53	10	65413	1316	110522560
Organ failure	16.21	14.53	17	65406	4800	110519076
Suicidal ideation	16.19	14.53	19	65404	93918	110429958
Allogenic stem cell transplantation	16.16	14.53	6	65417	253	110523623
Dysgeusia	16.14	14.53	83	65340	69902	110453974
Eosinophil percentage abnormal	16.01	14.53	3	65420	6	110523870
Transfusion microchimerism	16.01	14.53	3	65420	6	110523870
Thyroiditis subacute	15.99	14.53	7	65416	454	110523422
Deep vein thrombosis	15.99	14.53	37	65386	139850	110384026
Hepatosplenomegaly	15.82	14.53	20	65403	6899	110516977
Muscle spasticity	15.80	14.53	52	65371	35863	110488013
Infusion site swelling	15.75	14.53	24	65399	9853	110514023
Pneumonia aspiration	15.60	14.53	15	65408	81218	110442658
Citric acid urine increased	15.35	14.53	4	65419	50	110523826
White blood cell count increased	15.32	14.53	104	65319	96738	110427138
Dyspnoea	15.32	14.53	519	64904	1106353	109417523
Tremor	15.31	14.53	185	65238	202047	110321829
Rash	15.29	14.53	612	64811	820352	109703524
Infusion site rash	15.29	14.53	12	65411	2331	110521545
JC polyomavirus test positive	15.27	14.53	12	65411	2335	110521541
Increased tendency to bruise	15.24	14.53	26	65397	11732	110512144
Taste disorder	15.16	14.53	10	65413	65377	110458499
Bilirubin urine	15.15	14.53	3	65420	9	110523867
Fungal test positive	15.09	14.53	9	65414	1118	110522758
CD8 lymphocytes decreased	15.06	14.53	6	65417	307	110523569
Dysuria	15	14.53	73	65350	60158	110463718
Therapy cessation	14.97	14.53	4	65419	44853	110479023
Cerebral mass effect	14.95	14.53	12	65411	2407	110521469
Mobility decreased	14.90	14.53	81	65342	237341	110286535
Staphylococcal scalded skin syndrome	14.87	14.53	7	65416	538	110523338
Ureaplasma infection	14.83	14.53	10	65413	1536	110522340
Klebsiella test positive	14.83	14.53	12	65411	2434	110521442
Respiratory arrest	14.81	14.53	8	65415	58291	110465585
Femur fracture	14.78	14.53	4	65419	44465	110479411
Microangiopathy	14.77	14.53	13	65410	2959	110520917
Blepharospasm	14.72	14.53	7	65416	54844	110469032
Reticulocytopenia	14.70	14.53	6	65417	327	110523549
Lung consolidation	14.69	14.53	24	65399	10452	110513424
Flat affect	14.58	14.53	12	65411	2493	110521383
Incorrect route of product administration	14.58	14.53	10	65413	64051	110459825

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L04AG06	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Monoclonal antibodies
FDA MoA	N0000175079	CD52-directed Antibody Interactions
MeSH PA	D000074322	Antineoplastic Agents, Immunological
MeSH PA	D000970	Antineoplastic Agents
FDA EPC	N0000175659	CD52-directed Cytolytic Antibody
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35705	immunosuppressive agent
CHEBI has role	CHEBI:35842	antirheumatic drug
CHEBI has role	CHEBI:75835	anti-anaemic agent
CHEBI has role	CHEBI:231911	renoprotective agent

Related Drugs by ATC class:

L04AG Monoclonal antibodies 14 drugs

anifrolumab axatilimab-csfr belimumab efalizumab emapalumab inebilizumab muromonab-CD3 natalizumab ocrelizumab ofatumumab sibeprenlimab-szsi teprotumumab show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Refractory chronic lymphocytic leukemia	indication	92814006
Conditioning treatment prior to allogeneic haematopoietic stem cell transplant	indication	234336002
Relapsing remitting multiple sclerosis	indication	426373005	DOID:2378
Recurrent chronic lymphocytic leukemia	indication	122961000119105

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
CAMPATH-1 antigen	Surface antigen	P31358	CD52_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D02802	KEGG_DRUG
4021265	VUID
N0000148705	NUI
4021265	VANDF
CHEBI:749551	CHEBI
CHEMBL1201587	ChEMBL_ID
6770	IUPHAR_LIGAND_ID
DB00087	DRUGBANK_ID
117055	RXNORM
16025	MMSL
213286	MMSL
41389	MMSL
d04756	MMSL
009168	NDDF
009169	NDDF
129472003	SNOMEDCT_US
391632007	SNOMEDCT_US
C0383429	UMLSCUI
D000074323	MESH_DESCRIPTOR_UI
8005	INN_ID
3A189DH42V	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
LEMTRADA	HUMAN PRESCRIPTION DRUG LABEL	1	58468-0200	INJECTION, SOLUTION, CONCENTRATE	12 mg	INTRAVENOUS	BLA	29 sections
Campath	HUMAN PRESCRIPTION DRUG LABEL	1	58468-0357	INJECTION	30 mg	INTRAVENOUS	BLA	28 sections

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alemtuzumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: