alemtuzumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4909 216503-57-0

Description:

MoleculeDescription

Synonyms:

  • campath
  • alemtuzumab
  • lemtrada
Alemtuzumab binds to CD52, an antigen present on the surface of B and T lymphocytes, a majority of monocytes, macrophages, NK cells, and a subpopulation of granulocytes. A proportion of bone marrow cells, including some CD34+ cells, express variable levels of CD52. The proposed mechanism of action is antibody-dependent cellular-mediated lysis following cell surface binding of alemtuzumab to the leukemic cells.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.13 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 7, 2001 FDA GENZYME
Sept. 26, 2014 PMDA SANOFI K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lymphocyte count decreased 955.64 15.20 443 41115 29814 63417650
Immune thrombocytopenia 835.43 15.20 299 41259 10257 63437207
Urine abnormality 738.50 15.20 246 41312 6773 63440691
Urinary sediment present 484.00 15.20 136 41422 2067 63445397
Multiple sclerosis relapse 473.24 15.20 329 41229 48149 63399315
White blood cells urine positive 457.16 15.20 159 41399 4999 63442465
Urine leukocyte esterase positive 455.78 15.20 145 41413 3434 63444030
Red blood cells urine positive 441.21 15.20 137 41421 2989 63444475
Lymphocyte percentage decreased 388.64 15.20 123 41435 2862 63444602
Blood urine present 376.39 15.20 188 41370 14881 63432583
Cytomegalovirus infection 366.30 15.20 206 41352 20746 63426718
Crystal urine present 353.78 15.20 100 41458 1554 63445910
Neutrophil percentage increased 353.26 15.20 114 41444 2829 63444635
Urine analysis abnormal 348.03 15.20 129 41429 4887 63442577
Lymphopenia 344.48 15.20 189 41369 18138 63429326
Adenovirus infection 327.74 15.20 113 41445 3458 63444006
Bacterial test positive 259.93 15.20 106 41452 5201 63442263
Urine ketone body present 256.34 15.20 86 41472 2417 63445047
Bacterial test 246.66 15.20 70 41488 1104 63446360
Autoimmune thyroiditis 245.63 15.20 94 41464 3892 63443572
Blood thyroid stimulating hormone decreased 243.15 15.20 97 41461 4493 63442971
Flushing 241.41 15.20 271 41287 74816 63372648
Nitrite urine present 221.43 15.20 63 41495 1003 63446461
Hyperthyroidism 215.86 15.20 129 41429 14544 63432920
Red cell distribution width increased 212.95 15.20 114 41444 10410 63437054
Graft versus host disease in skin 206.26 15.20 76 41482 2829 63444635
Bradycardia 196.60 15.20 241 41317 72986 63374478
Drug ineffective 189.72 15.20 245 41313 1044520 62402944
Blood thyroid stimulating hormone increased 177.38 15.20 89 41469 7105 63440359
Haemoglobin urine present 172.58 15.20 49 41509 774 63446690
Culture urine positive 171.57 15.20 71 41487 3616 63443848
Chest discomfort 163.39 15.20 273 41285 109696 63337768
Drug intolerance 156.59 15.20 12 41546 308649 63138815
Haematocrit decreased 152.78 15.20 157 41401 39183 63408281
Leukocyturia 149.22 15.20 50 41508 1399 63446065
Protein urine present 148.79 15.20 75 41483 6045 63441419
Monocyte percentage increased 148.17 15.20 47 41511 1101 63446363
Headache 147.72 15.20 808 40750 632433 62815031
Platelet count decreased 147.43 15.20 269 41289 115853 63331611
Graft versus host disease 147.41 15.20 77 41481 6686 63440778
Post transplant lymphoproliferative disorder 144.26 15.20 69 41489 4962 63442502
Pyrexia 144.18 15.20 649 40909 469829 62977635
Specific gravity urine decreased 143.64 15.20 42 41516 740 63446724
Thyroxine free increased 138.56 15.20 42 41516 842 63446622
Rheumatoid arthritis 137.28 15.20 7 41551 253812 63193652
Product dose omission issue 135.06 15.20 4 41554 234309 63213155
Drug hypersensitivity 132.84 15.20 22 41536 310665 63136799
Neutrophil count increased 131.09 15.20 99 41459 16428 63431036
Magnetic resonance imaging abnormal 128.80 15.20 55 41503 3030 63444434
Mean cell haemoglobin decreased 127.47 15.20 64 41494 5115 63442349
Monocyte count decreased 122.79 15.20 48 41510 2105 63445359
Viraemia 122.13 15.20 42 41516 1274 63446190
White blood cell count decreased 121.54 15.20 276 41282 138828 63308636
Contraindicated product administered 117.69 15.20 6 41552 217642 63229822
Arthropathy 116.61 15.20 10 41548 234782 63212682
Epstein-Barr virus infection 116.38 15.20 70 41488 7980 63439484
Systemic lupus erythematosus 115.42 15.20 5 41553 208913 63238551
Anti-thyroid antibody positive 115.05 15.20 31 41527 399 63447065
Acute graft versus host disease in skin 113.37 15.20 52 41506 3400 63444064
Synovitis 108.40 15.20 3 41555 186915 63260549
Cytomegalovirus viraemia 108.16 15.20 59 41499 5590 63441874
Joint swelling 107.67 15.20 40 41518 327626 63119838
Feeling hot 107.40 15.20 148 41410 50206 63397258
Autoimmune haemolytic anaemia 102.04 15.20 53 41505 4548 63442916
Tachycardia 101.59 15.20 233 41325 117923 63329541
Death 99.64 15.20 61 41497 374320 63073144
Drug interaction 98.39 15.20 16 41542 229115 63218349
Treatment failure 97.41 15.20 9 41549 199034 63248430
Epstein-Barr viraemia 96.72 15.20 33 41525 977 63446487
Varicella zoster virus infection 96.20 15.20 43 41515 2646 63444818
Drug monitoring procedure not performed 95.31 15.20 29 41529 589 63446875
Graft versus host disease in gastrointestinal tract 94.60 15.20 45 41513 3196 63444268
Urinary casts 93.69 15.20 30 41528 725 63446739
Herpes zoster 92.17 15.20 181 41377 82281 63365183
Swelling 91.49 15.20 33 41525 275345 63172119
Maternal exposure during pregnancy 90.91 15.20 17 41541 220045 63227419
Hand deformity 90.85 15.20 3 41555 159454 63288010
Transplant failure 89.20 15.20 35 41523 1550 63445914
Endocrine ophthalmopathy 88.79 15.20 28 41530 643 63446821
Monocyte count increased 87.75 15.20 57 41501 7436 63440028
CD4 lymphocytes decreased 85.58 15.20 33 41525 1394 63446070
BK virus infection 85.07 15.20 42 41516 3237 63444227
Eosinophil count increased 83.44 15.20 64 41494 10864 63436600
Pain 82.59 15.20 232 41326 740396 62707068
Hypothyroidism 81.59 15.20 119 41439 42513 63404951
Red blood cells urine 80.72 15.20 25 41533 540 63446924
Body temperature increased 80.33 15.20 110 41448 37082 63410382
Listeriosis 80.05 15.20 32 41526 1489 63445975
Wound 78.25 15.20 8 41550 163255 63284209
Product use issue 77.46 15.20 24 41534 220496 63226968
Mean cell volume decreased 77.41 15.20 42 41516 3936 63443528
Urobilinogen urine increased 77.18 15.20 21 41537 281 63447183
Autoimmune thyroid disorder 76.73 15.20 13 41545 7 63447457
Muscular weakness 76.63 15.20 214 41344 122139 63325325
Heavy menstrual bleeding 76.45 15.20 75 41483 17698 63429766
Red blood cell count increased 75.24 15.20 38 41520 3074 63444390
Toxicity to various agents 74.99 15.20 34 41524 247216 63200248
Alopecia 74.28 15.20 67 41491 337469 63109995
Infusion site pain 74.08 15.20 72 41486 16797 63430667
Blood thyroid stimulating hormone abnormal 73.52 15.20 26 41532 858 63446606
CD4 lymphocytes abnormal 71.13 15.20 12 41546 6 63447458
Lymphocyte count abnormal 70.97 15.20 24 41534 691 63446773
Venoocclusive disease 70.73 15.20 32 41526 2026 63445438
Growth failure 70.25 15.20 20 41538 319 63447145
Cells in urine 69.38 15.20 18 41540 198 63447266
Diarrhoea 69.16 15.20 239 41319 715127 62732337
Leukopenia 68.15 15.20 154 41404 77136 63370328
Petechiae 66.12 15.20 62 41496 13835 63433629
Red blood cell count decreased 65.83 15.20 105 41453 40540 63406924
Urticaria 64.89 15.20 247 41311 165555 63281909
Red cell distribution width decreased 64.36 15.20 30 41528 2035 63445429
Overdose 62.72 15.20 3 41555 115075 63332389
Tri-iodothyronine free decreased 62.16 15.20 18 41540 306 63447158
Mean cell haemoglobin concentration decreased 61.70 15.20 35 41523 3577 63443887
Injection site pain 60.56 15.20 7 41551 129793 63317671
Autoimmune hypothyroidism 60.41 15.20 16 41542 192 63447272
Blood creatinine decreased 59.64 15.20 40 41518 5505 63441959
Urine leukocyte esterase 59.39 15.20 15 41543 147 63447317
Arthralgia 59.37 15.20 184 41374 569526 62877938
Tri-iodothyronine free increased 59.09 15.20 16 41542 210 63447254
Band sensation 58.89 15.20 22 41536 851 63446613
Eosinophil percentage increased 58.89 15.20 23 41535 1006 63446458
Chills 58.34 15.20 185 41373 113193 63334271
Poor quality sleep 57.34 15.20 68 41490 19867 63427597
Human herpesvirus 6 infection 56.93 15.20 31 41527 2926 63444538
Hepatic enzyme increased 56.55 15.20 31 41527 202297 63245167
Hypersensitivity 54.38 15.20 67 41491 292618 63154846
pH urine increased 54.13 15.20 17 41541 385 63447079
Haemophagocytic lymphohistiocytosis 53.64 15.20 49 41509 10578 63436886
Autoimmune disorder 53.43 15.20 61 41497 17116 63430348
Acute graft versus host disease in intestine 53.24 15.20 25 41533 1724 63445740
Transplant rejection 53.04 15.20 49 41509 10731 63436733
Multiple sclerosis 52.50 15.20 72 41486 24300 63423164
Thyroxine free decreased 52.29 15.20 19 41539 679 63446785
Haemoglobin decreased 52.26 15.20 211 41347 145274 63302190
Menstruation irregular 51.25 15.20 40 41518 6964 63440500
Therapeutic product effect incomplete 50.90 15.20 10 41548 125046 63322418
Encephalitis viral 50.40 15.20 24 41534 1708 63445756
Specific gravity urine increased 50.22 15.20 14 41544 206 63447258
Acute graft versus host disease 50.18 15.20 33 41525 4395 63443069
Abdominal discomfort 50.17 15.20 83 41475 320802 63126662
Eosinophil percentage decreased 49.85 15.20 14 41544 212 63447252
Meningitis listeria 49.60 15.20 18 41540 641 63446823
Thyroid stimulating immunoglobulin 49.50 15.20 11 41547 58 63447406
Mean cell haemoglobin concentration increased 49.48 15.20 17 41541 514 63446950
Impaired healing 49.18 15.20 5 41553 102537 63344927
Band neutrophil percentage increased 48.57 15.20 14 41544 234 63447230
Gastrointestinal disorder 48.42 15.20 13 41545 131226 63316238
White blood cells urine 47.53 15.20 16 41542 454 63447010
Fall 47.28 15.20 118 41440 392216 63055248
Pericarditis 46.76 15.20 14 41544 131565 63315899
Thyroid function test abnormal 45.81 15.20 29 41529 3618 63443846
Crystalluria 45.16 15.20 15 41543 408 63447056
Osteoarthritis 44.83 15.20 5 41553 95338 63352126
Anti-glomerular basement membrane disease 44.33 15.20 7 41551 0 63447464
Heart rate increased 44.18 15.20 149 41409 94089 63353375
Monocyte percentage decreased 44.09 15.20 13 41545 236 63447228
Discomfort 43.44 15.20 28 41530 167346 63280118
Herpes simplex 43.44 15.20 39 41519 8232 63439232
Thrombocytopenia 43.42 15.20 205 41353 150952 63296512
Feeling cold 43.28 15.20 65 41493 23823 63423641
Myelocyte count increased 43.04 15.20 14 41544 356 63447108
Creatinine urine decreased 42.35 15.20 12 41546 188 63447276
Peripheral swelling 42.29 15.20 68 41490 265874 63181590
Insomnia 42.22 15.20 263 41295 214989 63232475
Band neutrophil count increased 42.15 15.20 14 41544 381 63447083
Arthritis 41.80 15.20 12 41546 115909 63331555
Guillain-Barre syndrome 41.67 15.20 28 41530 3865 63443599
Acute disseminated encephalomyelitis 41.66 15.20 12 41546 200 63447264
Urinary tract infection 41.53 15.20 306 41252 264378 63183086
Fibromyalgia 41.08 15.20 3 41555 80417 63367047
T-lymphocyte count decreased 41.04 15.20 13 41545 303 63447161
Neutropenia 40.91 15.20 224 41334 174781 63272683
Platelet count abnormal 40.40 15.20 26 41532 3338 63444126
Menstrual disorder 40.30 15.20 31 41527 5282 63442182
Irritable bowel syndrome 39.57 15.20 4 41554 82408 63365056
Urine oxalate increased 39.15 15.20 12 41546 250 63447214
Cytomegalovirus infection reactivation 38.85 15.20 27 41531 3936 63443528
Neuropathy peripheral 38.77 15.20 13 41545 113654 63333810
Bacteriuria 38.18 15.20 17 41541 1036 63446428
Chronic graft versus host disease in liver 38.03 15.20 12 41546 276 63447188
Gingival bleeding 37.97 15.20 44 41514 12543 63434921
Stomatitis 37.67 15.20 22 41536 138703 63308761
Injection site erythema 37.53 15.20 5 41553 83169 63364295
Myelocyte percentage increased 37.14 15.20 11 41547 203 63447261
Atrial fibrillation 36.98 15.20 15 41543 116621 63330843
Urinary tract infection bacterial 36.93 15.20 29 41529 5093 63442371
Acute myeloid leukaemia recurrent 36.86 15.20 19 41539 1604 63445860
Drug abuse 36.21 15.20 3 41555 72515 63374949
Bilirubin urine present 36.12 15.20 9 41549 83 63447381
Pulmonary haemorrhage 36.02 15.20 33 41525 7148 63440316
Cystitis haemorrhagic 35.60 15.20 26 41532 4097 63443367
Quadriparesis 35.57 15.20 20 41538 2009 63445455
Multiple organ dysfunction syndrome 35.24 15.20 99 41459 56653 63390811
Pulmonary alveolar haemorrhage 34.89 15.20 27 41531 4641 63442823
Viral haemorrhagic cystitis 34.66 15.20 15 41543 854 63446610
Neutrophil count decreased 34.63 15.20 98 41460 56308 63391156
Sinus bradycardia 34.42 15.20 45 41513 14506 63432958
Injury 34.03 15.20 4 41554 73243 63374221
Heart rate decreased 33.89 15.20 85 41473 45475 63401989
Oropharyngeal pain 33.87 15.20 137 41421 94350 63353114
Drug exposure before pregnancy 33.62 15.20 15 41543 919 63446545
Optic neuritis 33.33 15.20 34 41524 8401 63439063
Adverse drug reaction 33.23 15.20 6 41552 79708 63367756
Autoimmune neutropenia 33.20 15.20 10 41548 196 63447268
Myocardial infarction 33.08 15.20 12 41546 99881 63347583
Thrombotic thrombocytopenic purpura 32.69 15.20 24 41534 3812 63443652
Haemorrhagic adrenal infarction 32.69 15.20 7 41551 30 63447434
Hypoaesthesia 31.91 15.20 204 41354 168189 63279275
Thyroid stimulating immunoglobulin increased 31.80 15.20 8 41550 77 63447387
Central nervous system lesion 31.78 15.20 37 41521 10598 63436866
Confusional state 31.74 15.20 67 41491 236313 63211151
Proteinuria 31.74 15.20 50 41508 19095 63428369
Idiopathic pneumonia syndrome 31.51 15.20 11 41547 349 63447115
Oedema peripheral 31.51 15.20 47 41511 189464 63258000
Psoriasis 31.35 15.20 9 41549 86948 63360516
Mean cell haemoglobin increased 31.10 15.20 21 41537 2922 63444542
Intentional product use issue 31.05 15.20 23 41535 127869 63319595
Infusion related reaction 30.99 15.20 72 41486 245449 63202015
Throat irritation 30.95 15.20 73 41485 37574 63409890
Adverse event 30.63 15.20 4 41554 67555 63379909
Limb discomfort 30.51 15.20 63 41495 29653 63417811
Mean platelet volume increased 30.36 15.20 12 41546 542 63446922
Thrombotic microangiopathy 30.33 15.20 36 41522 10525 63436939
Basophil count increased 30.12 15.20 14 41544 943 63446521
Cellulitis staphylococcal 30.12 15.20 13 41545 735 63446729
Chronic graft versus host disease in skin 30.04 15.20 13 41545 740 63446724
Folliculitis 29.95 15.20 5 41553 70312 63377152
Immature granulocyte count increased 29.91 15.20 11 41547 407 63447057
Depressed level of consciousness 29.83 15.20 3 41555 62075 63385389
Mean cell volume increased 29.78 15.20 22 41536 3529 63443935
Parvovirus infection 29.67 15.20 10 41548 285 63447179
Basophil percentage increased 29.61 15.20 8 41550 104 63447360
Acute kidney injury 29.58 15.20 82 41476 263333 63184131
Granulocyte percentage 29.09 15.20 7 41551 55 63447409
Infusion site extravasation 29.05 15.20 35 41523 10391 63437073
Eosinophil count decreased 28.98 15.20 18 41540 2172 63445292
B-lymphocyte count increased 28.94 15.20 8 41550 114 63447350
White blood cell count increased 28.48 15.20 83 41475 48478 63398986
Mycobacterium kansasii infection 28.25 15.20 8 41550 125 63447339
Chronic obstructive pulmonary disease 27.74 15.20 4 41554 62682 63384782
Listeria test positive 27.72 15.20 5 41553 6 63447458
Progressive multifocal leukoencephalopathy 27.45 15.20 38 41520 12933 63434531
Sinusitis 27.39 15.20 68 41490 226585 63220879
Polyomavirus viraemia 27.10 15.20 12 41546 722 63446742
Gastroenteritis adenovirus 26.92 15.20 9 41549 250 63447214
Lymphadenopathy 26.79 15.20 70 41488 38388 63409076
Exophthalmos 26.73 15.20 15 41543 1501 63445963
Lipaemic index score 26.66 15.20 7 41551 81 63447383
Temperature intolerance 26.48 15.20 31 41527 8933 63438531
Laboratory test abnormal 26.40 15.20 56 41502 26856 63420608
Type 2 diabetes mellitus 26.20 15.20 5 41553 63863 63383601
Hypoglycaemia 26.19 15.20 4 41554 60061 63387403
Creatinine urine increased 25.77 15.20 9 41549 286 63447178
Bronchopulmonary aspergillosis 25.73 15.20 30 41528 8605 63438859
Pathogen resistance 25.67 15.20 26 41532 6372 63441092
Haematuria 25.57 15.20 58 41500 29099 63418365
Haematocrit increased 25.54 15.20 17 41541 2309 63445155
Goodpasture's syndrome 25.33 15.20 4 41554 0 63447464
Injection site reaction 25.29 15.20 4 41554 58520 63388944
Vitiligo 25.19 15.20 14 41544 1375 63446089
Legionella infection 25.12 15.20 10 41548 460 63447004
Musculoskeletal stiffness 25.05 15.20 52 41506 184566 63262898
Fibrin D dimer increased 24.99 15.20 23 41535 5011 63442453
Vulvovaginal mycotic infection 24.89 15.20 24 41534 5542 63441922
Actinomycotic sepsis 24.80 15.20 7 41551 108 63447356
Serum amyloid A protein increased 24.63 15.20 9 41549 327 63447137
Anaemia 24.36 15.20 104 41454 293326 63154138
Incorrect dose administered 23.96 15.20 5 41553 59963 63387501
Blister 23.78 15.20 30 41528 129784 63317680
Epstein-Barr virus associated lymphoproliferative disorder 23.64 15.20 15 41543 1879 63445585
Haemolytic anaemia 23.46 15.20 31 41527 10094 63437370
Infertility 23.27 15.20 11 41547 770 63446694
Micturition urgency 23.16 15.20 30 41528 9581 63437883
Immune reconstitution inflammatory syndrome 23.10 15.20 24 41534 6060 63441404
Expanded disability status scale score increased 22.83 15.20 10 41548 586 63446878
Haemoglobin increased 22.81 15.20 19 41539 3627 63443837
Pollakiuria 22.77 15.20 54 41504 27883 63419581
Glomerulonephritis chronic 22.70 15.20 7 41551 149 63447315
Vaginal discharge 22.62 15.20 29 41529 9169 63438295
Glomerulonephritis membranous 22.61 15.20 10 41548 600 63446864
Nasal septum disorder 22.56 15.20 7 41551 152 63447312
Suicide attempt 22.53 15.20 6 41552 60912 63386552
Hyponatraemia 22.50 15.20 24 41534 111876 63335588
Erythema 22.50 15.20 194 41364 175557 63271907
Cystitis viral 22.48 15.20 7 41551 154 63447310
Neutrophil percentage decreased 22.29 15.20 9 41549 430 63447034
Fusarium infection 22.06 15.20 10 41548 636 63446828
Retinal depigmentation 22.04 15.20 8 41550 285 63447179
Ureaplasma infection 21.98 15.20 10 41548 641 63446823
Oral herpes 21.91 15.20 51 41507 26023 63421441
Anaphylactic reaction 21.78 15.20 8 41550 66092 63381372
Systemic mycosis 21.53 15.20 12 41546 1185 63446279
Decreased appetite 21.44 15.20 88 41470 250964 63196500
Interleukin-2 receptor increased 21.30 15.20 6 41552 92 63447372
Hemiparesis 21.19 15.20 47 41511 23235 63424229
Mean platelet volume decreased 21.18 15.20 16 41542 2653 63444811
Platelet count increased 21.14 15.20 40 41518 17671 63429793
Immature granulocyte percentage increased 21.04 15.20 5 41553 37 63447427
Cytokine storm 20.97 15.20 8 41550 328 63447136
Autoimmune pancytopenia 20.94 15.20 6 41552 98 63447366
Malignant neoplasm progression 20.94 15.20 14 41544 82107 63365357
Oesophageal candidiasis 20.89 15.20 22 41536 5641 63441823
Haemoptysis 20.74 15.20 53 41505 28673 63418791
Malignant melanoma 20.71 15.20 31 41527 11325 63436139
Feeling abnormal 20.69 15.20 167 41391 148225 63299239
Loss of personal independence in daily activities 20.54 15.20 20 41538 97270 63350194
Contusion 20.46 15.20 168 41390 149876 63297588
Growth retardation 20.26 15.20 12 41546 1329 63446135
Hepatitis infectious mononucleosis 20.24 15.20 6 41552 111 63447353
Blood cholesterol increased 20.24 15.20 19 41539 94013 63353451
Graft loss 20.16 15.20 8 41550 365 63447099
Gastroenteritis norovirus 20.06 15.20 14 41544 2054 63445410
Asthma 19.89 15.20 33 41525 127528 63319936
Chronic kidney disease 19.85 15.20 3 41555 45395 63402069
Cerebrovascular accident 19.74 15.20 25 41533 107999 63339465
Periportal oedema 19.55 15.20 4 41554 13 63447451
Cytomegalovirus chorioretinitis 19.44 15.20 13 41545 1780 63445684
Infusion site discomfort 19.43 15.20 12 41546 1434 63446030
JC polyomavirus test positive 19.37 15.20 12 41546 1441 63446023
Post herpetic neuralgia 19.29 15.20 14 41544 2185 63445279
Dysuria 19.15 15.20 57 41501 33681 63413783
White blood cell count abnormal 19.13 15.20 22 41536 6220 63441244
Loefgren syndrome 19.10 15.20 6 41552 136 63447328
Chronic graft versus host disease 19.06 15.20 16 41542 3086 63444378
Brain stem syndrome 19.06 15.20 8 41550 422 63447042
Chromaturia 19.03 15.20 37 41521 16680 63430784
Fumbling 18.78 15.20 6 41552 144 63447320
Urine odour abnormal 18.71 15.20 22 41536 6367 63441097
Thyroiditis subacute 18.66 15.20 7 41551 274 63447190
Palpitations 18.58 15.20 132 41426 112638 63334826
Bladder dysfunction 18.56 15.20 10 41548 924 63446540
Cardiac failure congestive 18.38 15.20 20 41538 92413 63355051
Bone marrow transplant rejection 18.37 15.20 5 41553 67 63447397
Cellulitis 18.31 15.20 16 41542 81942 63365522
Cough 18.29 15.20 281 41277 292462 63155002
Goitre 18.25 15.20 21 41537 5940 63441524
Bronchostenosis 18.24 15.20 8 41550 470 63446994
C-reactive protein abnormal 18.10 15.20 4 41554 46092 63401372
Lymphocyte percentage increased 18.09 15.20 8 41550 480 63446984
Meningism 17.98 15.20 8 41550 487 63446977
Thyroiditis 17.86 15.20 14 41544 2452 63445012
Joint stiffness 17.78 15.20 3 41555 41866 63405598
Engraftment syndrome 17.78 15.20 8 41550 500 63446964
Lymphodepletion 17.71 15.20 4 41554 23 63447441
Injection site pruritus 17.54 15.20 4 41554 45112 63402352
Infusion site scar 17.54 15.20 8 41550 516 63446948
Chronic hepatitis C 17.45 15.20 6 41552 182 63447282
Oedema 17.42 15.20 23 41535 97599 63349865
Microcytosis 17.41 15.20 6 41552 183 63447281
Acute motor axonal neuropathy 17.29 15.20 4 41554 26 63447438
Maternal exposure before pregnancy 17.19 15.20 23 41535 7580 63439884
Lymphocyte percentage abnormal 17.16 15.20 4 41554 27 63447437
Epstein-Barr virus infection reactivation 17.14 15.20 9 41549 789 63446675
Exposure during pregnancy 17.01 15.20 49 41509 155498 63291966
Injection site swelling 17.00 15.20 5 41553 47567 63399897
Monocyte count abnormal 16.99 15.20 6 41552 197 63447267
Pneumonia cytomegaloviral 16.97 15.20 13 41545 2201 63445263
Sleep disorder 16.95 15.20 17 41541 81549 63365915
Natural killer cell count increased 16.92 15.20 3 41555 3 63447461
CD4 lymphocyte percentage decreased 16.92 15.20 3 41555 3 63447461
Blood pressure systolic increased 16.91 15.20 5 41553 47392 63400072
Pseudomonas infection 16.83 15.20 28 41530 11185 63436279
Evans syndrome 16.74 15.20 6 41552 206 63447258
Hypogammaglobulinaemia 16.72 15.20 22 41536 7133 63440331
Anti-thyroid antibody 16.67 15.20 4 41554 31 63447433
Autoimmune hepatitis 16.63 15.20 24 41534 8486 63438978
Thyroid disorder 16.58 15.20 33 41525 15129 63432335
Cervical dysplasia 16.57 15.20 15 41543 3199 63444265
Nitrite urine 16.45 15.20 4 41554 33 63447431
Diverticulitis 16.43 15.20 3 41555 39554 63407910
Thyroid cyst 16.42 15.20 8 41550 599 63446865
Klebsiella test positive 16.33 15.20 10 41548 1177 63446287
Cardiac arrest 16.31 15.20 22 41536 92523 63354941
Diffuse large B-cell lymphoma 16.25 15.20 21 41537 6691 63440773
Blood luteinising hormone decreased 16.24 15.20 4 41554 35 63447429
Musculoskeletal pain 16.20 15.20 22 41536 92255 63355209
Disorder of globe 16.06 15.20 3 41555 5 63447459
Tri-iodothyronine free abnormal 16.04 15.20 4 41554 37 63447427
Sedation 16 15.20 3 41555 38806 63408658
Poor venous access 15.95 15.20 32 41526 14753 63432711
Dehydration 15.92 15.20 59 41499 173295 63274169
Chronic lymphocytic leukaemia recurrent 15.92 15.20 6 41552 238 63447226
Pneumonitis 15.89 15.20 55 41503 35167 63412297
Hallucination 15.89 15.20 8 41550 54809 63392655
Thyroxine decreased 15.86 15.20 8 41550 645 63446819
Lower respiratory tract infection 15.73 15.20 40 41518 132267 63315197
Lactic acidosis 15.70 15.20 3 41555 38284 63409180
Osteoporosis 15.69 15.20 9 41549 57329 63390135
Aspiration bone marrow abnormal 15.67 15.20 4 41554 41 63447423
Herpes zoster infection neurological 15.57 15.20 6 41552 253 63447211
Endometrial ablation 15.55 15.20 9 41549 955 63446509
Albumin urine present 15.48 15.20 6 41552 257 63447207
No adverse event 15.46 15.20 4 41554 41401 63406063
Extensor plantar response 15.42 15.20 10 41548 1301 63446163
Cytomegalovirus test positive 15.39 15.20 14 41544 3004 63444460
Fungal skin infection 15.37 15.20 17 41541 4605 63442859
Fungal infection 15.28 15.20 56 41502 36818 63410646

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 640.19 16.44 314 20988 25821 34909808
Post transplant lymphoproliferative disorder 377.26 16.44 144 21158 6384 34929245
Immune thrombocytopenia 376.47 16.44 158 21144 8994 34926635
Adenovirus infection 250.97 16.44 101 21201 5156 34930473
Autoimmune haemolytic anaemia 234.21 16.44 92 21210 4404 34931225
Lymphopenia 229.92 16.44 136 21166 16199 34919430
Epstein-Barr virus infection 224.10 16.44 104 21198 7524 34928105
Progressive multifocal leukoencephalopathy 168.81 16.44 93 21209 9671 34925958
Graft versus host disease 164.61 16.44 94 21208 10475 34925154
Lymphocyte count decreased 160.26 16.44 123 21179 22499 34913130
Transplant failure 151.60 16.44 63 21239 3490 34932139
End stage renal disease 146.61 16.44 82 21220 8779 34926850
Microsporidia infection 141.76 16.44 40 21262 666 34934963
Multiple sclerosis relapse 140.83 16.44 92 21210 13041 34922588
Pyrexia 138 16.44 480 20822 332533 34603096
Lymphocyte percentage decreased 137.53 16.44 51 21251 2081 34933548
JC virus infection 132.16 16.44 50 21252 2158 34933471
Graft versus host disease in gastrointestinal tract 120.06 16.44 54 21248 3629 34932000
Cytomegalovirus infection reactivation 117.66 16.44 59 21243 5059 34930570
Acute graft versus host disease in skin 110.94 16.44 57 21245 5144 34930485
BK virus infection 108.47 16.44 58 21244 5680 34929949
Transplant rejection 107.54 16.44 71 21231 10240 34925389
Herpes simplex 101.75 16.44 55 21247 5504 34930125
Neutrophil percentage increased 100.72 16.44 39 21263 1794 34933835
Cytomegalovirus viraemia 97.07 16.44 59 21243 7371 34928258
Crystal urine present 94.67 16.44 27 21275 468 34935161
Monocyte percentage increased 92.40 16.44 31 21271 938 34934691
Chronic graft versus host disease in skin 92.24 16.44 31 21271 943 34934686
Graft versus host disease in skin 77.93 16.44 41 21261 3884 34931745
Product use in unapproved indication 77.43 16.44 200 21102 117299 34818330
Epstein-Barr viraemia 75.96 16.44 29 21273 1283 34934346
Human herpesvirus 6 infection 75.84 16.44 33 21269 2048 34933581
Off label use 74.18 16.44 472 20830 419052 34516577
Blood thyroid stimulating hormone decreased 71.45 16.44 31 21271 1910 34933719
Meningitis viral 70.86 16.44 25 21277 882 34934747
Urine abnormality 70.58 16.44 31 21271 1968 34933661
Acute graft versus host disease in intestine 70.54 16.44 34 21268 2674 34932955
Drug interaction 70.33 16.44 25 21277 225921 34709708
Herpes zoster 69.65 16.44 95 21207 34304 34901325
Mucosal inflammation 66.89 16.44 99 21203 38523 34897106
Multiple organ dysfunction syndrome 65.17 16.44 144 21158 76422 34859207
Pneumonia cytomegaloviral 63.77 16.44 33 21269 3021 34932608
Haemolytic anaemia 61.40 16.44 51 21251 10428 34925201
Venoocclusive disease 59.92 16.44 31 21271 2836 34932793
Acute graft versus host disease 58.80 16.44 41 21261 6462 34929167
Thrombotic microangiopathy 58.71 16.44 50 21252 10580 34925049
Toxoplasmosis 58.39 16.44 24 21278 1292 34934337
Leukaemia recurrent 56.87 16.44 25 21277 1590 34934039
Aspergillus infection 56.43 16.44 52 21250 12202 34923427
Magnetic resonance imaging abnormal 56.27 16.44 25 21277 1631 34933998
Epstein-Barr virus associated lymphoproliferative disorder 55.25 16.44 26 21276 1938 34933691
Urine analysis abnormal 54.79 16.44 26 21276 1975 34933654
Autoimmune thyroiditis 54.10 16.44 22 21280 1152 34934477
Haemophagocytic lymphohistiocytosis 53.90 16.44 52 21250 12921 34922708
Chronic graft versus host disease in intestine 53.25 16.44 15 21287 248 34935381
Propionibacterium infection 53.08 16.44 15 21287 251 34935378
Graft loss 52.86 16.44 20 21282 863 34934766
Endocrine ophthalmopathy 52.77 16.44 11 21291 44 34935585
Chronic graft versus host disease 52.73 16.44 33 21269 4340 34931289
Pancytopenia 52.67 16.44 152 21150 95005 34840624
Epstein-Barr virus infection reactivation 51.94 16.44 21 21281 1083 34934546
Chronic graft versus host disease in liver 49.03 16.44 16 21286 443 34935186
Blood thyroid stimulating hormone increased 48.53 16.44 31 21271 4224 34931405
Polyomavirus viraemia 48.01 16.44 19 21283 926 34934703
Red blood cells urine positive 47.99 16.44 23 21279 1786 34933843
Diffuse large B-cell lymphoma 47.67 16.44 38 21264 7332 34928297
Bronchopulmonary aspergillosis 46.82 16.44 51 21251 14608 34921021
Meningitis tuberculous 46.44 16.44 17 21285 668 34934961
Polymyositis 46.39 16.44 21 21281 1432 34934197
White blood cells urine positive 45.49 16.44 20 21282 1272 34934357
Toxicity to various agents 44.81 16.44 34 21268 200328 34735301
Urine leukocyte esterase positive 44.64 16.44 15 21287 456 34935173
Bacterial test positive 44.13 16.44 26 21276 3067 34932562
Central nervous system lymphoma 43.08 16.44 18 21284 1010 34934619
Pyelonephritis fungal 43.04 16.44 10 21292 72 34935557
Completed suicide 42.48 16.44 5 21297 98163 34837466
Nitrite urine present 42.46 16.44 11 21291 130 34935499
Specific gravity urine increased 41.72 16.44 11 21291 140 34935489
Urine ketone body present 41.17 16.44 18 21284 1130 34934499
B-cell lymphoma 40.60 16.44 28 21274 4335 34931294
Enterococcal infection 39.98 16.44 38 21264 9268 34926361
CD4 lymphocytes decreased 39.80 16.44 20 21282 1721 34933908
Hyperthyroidism 39.53 16.44 40 21262 10526 34925103
Pseudomonas infection 39.41 16.44 43 21259 12339 34923290
Death 39.18 16.44 119 21183 397930 34537699
Chronic lymphocytic leukaemia transformation 38.55 16.44 11 21291 191 34935438
Cystitis viral 38.47 16.44 14 21288 541 34935088
Pulmonary nocardiosis 38.39 16.44 16 21286 892 34934737
Platelet count decreased 38.00 16.44 159 21143 119558 34816071
Varicella 37.56 16.44 19 21283 1658 34933971
Haematocrit decreased 37.42 16.44 69 21233 32147 34903482
Adenovirus reactivation 37.33 16.44 11 21291 215 34935414
Atypical mycobacterial pneumonia 37.18 16.44 10 21292 138 34935491
Venoocclusive liver disease 37.06 16.44 34 21268 7932 34927697
Arthralgia 36.56 16.44 30 21272 170011 34765618
Dyspnoea 36.10 16.44 114 21188 376668 34558961
Parainfluenzae virus infection 35.75 16.44 22 21280 2808 34932821
Chills 35.16 16.44 119 21183 80924 34854705
Anti-thyroid antibody positive 34.63 16.44 8 21294 56 34935573
Human polyomavirus infection 34.48 16.44 14 21288 730 34934899
Acanthamoeba infection 34.46 16.44 12 21290 407 34935222
Red cell distribution width increased 34.21 16.44 29 21273 6094 34929535
Mycobacterial infection 33.98 16.44 20 21282 2354 34933275
Mean cell haemoglobin concentration decreased 33.64 16.44 16 21286 1221 34934408
Viraemia 33.63 16.44 16 21286 1222 34934407
Varicella zoster virus infection 33.41 16.44 18 21284 1788 34933841
Dizziness 31.49 16.44 53 21249 218468 34717161
Diarrhoea 31.34 16.44 127 21175 389785 34545844
Nocardiosis 31.33 16.44 23 21279 3928 34931701
Eosinophil percentage increased 31.15 16.44 12 21290 544 34935085
Listeria sepsis 30.78 16.44 9 21293 171 34935458
Autoimmune disorder 30.75 16.44 17 21285 1777 34933852
Myocardial infarction 30.47 16.44 18 21284 121067 34814562
Fall 30.36 16.44 48 21254 202837 34732792
Lactobacillus infection 30.01 16.44 10 21292 296 34935333
Leukopenia 29.67 16.44 95 21207 62761 34872868
Bacterial sepsis 29.61 16.44 25 21277 5225 34930404
Bacteriuria 29.24 16.44 10 21292 321 34935308
Epstein-Barr virus associated lymphoma 29.01 16.44 12 21290 656 34934973
Meningeal neoplasm 28.85 16.44 7 21295 62 34935567
Petechiae 28.75 16.44 32 21270 9386 34926243
Neutropenia 28.46 16.44 178 21124 156600 34779029
Rhabdomyolysis 28.21 16.44 4 21298 68159 34867470
Stenotrophomonas infection 28.18 16.44 17 21285 2093 34933536
Lymphocyte count abnormal 28.09 16.44 14 21288 1184 34934445
Encephalitis 28.05 16.44 28 21274 7249 34928380
Aplastic anaemia 27.93 16.44 32 21270 9684 34925945
pH urine increased 27.48 16.44 7 21295 77 34935552
Bacterial test 27.16 16.44 8 21294 156 34935473
Myositis 26.97 16.44 35 21267 12035 34923594
Listeriosis 26.94 16.44 13 21289 1025 34934604
Anogenital warts 26.87 16.44 11 21291 586 34935043
White blood cell count decreased 26.63 16.44 122 21180 95323 34840306
Normocytic anaemia 26.54 16.44 17 21285 2327 34933302
Klebsiella sepsis 26.15 16.44 16 21286 2021 34933608
Band neutrophil percentage increased 25.55 16.44 7 21295 104 34935525
Stem cell transplant 25.43 16.44 16 21286 2123 34933506
Bone marrow transplant rejection 25.33 16.44 8 21294 199 34935430
Thrombocytopenia 25.07 16.44 172 21130 156075 34779554
Cytomegalovirus test positive 25.05 16.44 20 21282 3866 34931763
Drug hypersensitivity 24.85 16.44 9 21293 80520 34855109
Neutrophil percentage decreased 24.39 16.44 9 21293 362 34935267
Diarrhoea haemorrhagic 24.20 16.44 25 21277 6739 34928890
Graft versus host disease in lung 23.72 16.44 10 21292 574 34935055
Apoptosis 23.49 16.44 9 21293 402 34935227
Factor VIII deficiency 23.46 16.44 7 21295 143 34935486
Albuminuria 23.24 16.44 9 21293 414 34935215
Skin papilloma 23.19 16.44 15 21287 2088 34933541
Phaeohyphomycosis 22.96 16.44 11 21291 853 34934776
Bilirubin urine present 22.89 16.44 7 21295 156 34935473
Lymphadenopathy 22.47 16.44 52 21250 28411 34907218
Syncope 22.43 16.44 14 21288 91437 34844192
Norovirus infection 22.36 16.44 7 21295 169 34935460
Haemorrhagic cyst 22.23 16.44 6 21296 84 34935545
Enterococcal bacteraemia 22.08 16.44 14 21288 1883 34933746
Chronic lymphocytic leukaemia refractory 22.03 16.44 6 21296 87 34935542
Acute graft versus host disease in liver 21.91 16.44 13 21289 1553 34934076
Activated partial thromboplastin time shortened 21.90 16.44 9 21293 484 34935145
Specific gravity urine decreased 21.84 16.44 6 21296 90 34935539
Herpes zoster meningoencephalitis 21.84 16.44 8 21294 315 34935314
Meningitis listeria 21.74 16.44 9 21293 493 34935136
Confusional state 21.64 16.44 34 21268 144126 34791503
Mycobacterium kansasii infection 21.60 16.44 8 21294 325 34935304
Intracranial tumour haemorrhage 21.55 16.44 8 21294 327 34935302
Pneumonia fungal 21.45 16.44 24 21278 7076 34928553
Autoimmune pancytopenia 20.98 16.44 6 21296 105 34935524
Glucose urine present 20.78 16.44 11 21291 1054 34934575
Necrotising oesophagitis 20.70 16.44 9 21293 557 34935072
Haematocrit increased 20.70 16.44 14 21288 2099 34933530
Band sensation 20.57 16.44 6 21296 113 34935516
Blood urine present 20.53 16.44 29 21273 10805 34924824
Monocyte count abnormal 20.24 16.44 5 21297 48 34935581
Pneumocystis jirovecii pneumonia 20.15 16.44 40 21262 19670 34915959
Tuberculosis liver 20.15 16.44 5 21297 49 34935580
Complications of transplanted kidney 20.14 16.44 19 21283 4590 34931039
Retinitis 20.14 16.44 8 21294 394 34935235
Transplant dysfunction 20.06 16.44 15 21287 2634 34932995
Hypogammaglobulinaemia 19.77 16.44 24 21278 7716 34927913
Muscle spasticity 19.70 16.44 21 21281 5867 34929762
Leukaemic infiltration 19.65 16.44 6 21296 133 34935496
T-cell prolymphocytic leukaemia 19.55 16.44 5 21297 56 34935573
Thyroxine free increased 19.39 16.44 7 21295 264 34935365
Posterior reversible encephalopathy syndrome 19.39 16.44 27 21275 9927 34925702
Band neutrophil count increased 19.29 16.44 7 21295 268 34935361
Systemic mycosis 19.29 16.44 12 21290 1561 34934068
Granulocyte percentage 19.21 16.44 3 21299 0 34935629
Thyroid stimulating immunoglobulin 19.21 16.44 3 21299 0 34935629
Oral herpes 18.94 16.44 20 21282 5527 34930102
Urinary sediment present 18.91 16.44 7 21295 284 34935345
Respiratory failure 18.89 16.44 122 21180 108450 34827179
Papilloma viral infection 18.57 16.44 8 21294 484 34935145
Protein urine present 18.12 16.44 19 21283 5209 34930420
Acute myeloid leukaemia recurrent 18.04 16.44 13 21289 2157 34933472
Joint swelling 17.96 16.44 7 21295 59883 34875746
Fungal skin infection 17.93 16.44 14 21288 2620 34933009
Drug resistance 17.92 16.44 45 21257 25882 34909747
Device related infection 17.64 16.44 35 21267 17202 34918427
Chronic lymphocytic leukaemia 17.64 16.44 17 21285 4215 34931414
Coronary artery disease 17.47 16.44 4 21298 48301 34887328
Acute disseminated encephalomyelitis 17.40 16.44 5 21297 89 34935540
Cardiac failure 17.34 16.44 18 21284 91230 34844399
Oedema peripheral 17.28 16.44 29 21273 119783 34815846
Exophthalmos 17.27 16.44 8 21294 575 34935054
Constipation 17.25 16.44 36 21266 136946 34798683
Respiratory disorder 17.23 16.44 37 21265 19227 34916402
Pneumonia adenoviral 17.15 16.44 7 21295 370 34935259
Gastroenteritis norovirus 17.11 16.44 11 21291 1515 34934114
Polyomavirus-associated nephropathy 17.09 16.44 16 21286 3828 34931801
Herpes virus infection 16.99 16.44 14 21288 2828 34932801
International normalised ratio increased 16.95 16.44 4 21298 47323 34888306
Cerebrovascular accident 16.95 16.44 16 21286 84795 34850834
Monocyte count decreased 16.69 16.44 10 21292 1216 34934413
Platelet count abnormal 16.65 16.44 14 21288 2908 34932721
Chronic lymphocytic leukaemia recurrent 16.58 16.44 7 21295 403 34935226
B-lymphocyte count decreased 16.52 16.44 8 21294 635 34934994

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lymphocyte count decreased 1015.91 13.52 555 58489 46734 79638610
Immune thrombocytopenia 928.47 13.52 385 58659 17420 79667924
Cytomegalovirus infection 920.12 13.52 502 58542 42142 79643202
Urine abnormality 783.50 13.52 276 58768 7943 79677401
Multiple sclerosis relapse 543.75 13.52 370 58674 46163 79639181
Post transplant lymphoproliferative disorder 524.59 13.52 226 58818 11238 79674106
Adenovirus infection 513.50 13.52 204 58840 8243 79677101
Lymphocyte percentage decreased 504.56 13.52 175 58869 4801 79680543
Lymphopenia 501.29 13.52 301 58743 30256 79655088
White blood cells urine positive 496.23 13.52 182 58862 5893 79679451
Urine leukocyte esterase positive 493.87 13.52 164 58880 3927 79681417
Urinary sediment present 470.04 13.52 141 58903 2394 79682950
Red blood cells urine positive 455.24 13.52 162 58882 4801 79680543
Neutrophil percentage increased 437.47 13.52 155 58889 4534 79680810
Crystal urine present 430.31 13.52 127 58917 2033 79683311
Urine analysis abnormal 408.67 13.52 161 58883 6359 79678985
Blood urine present 375.96 13.52 220 58824 21077 79664267
Autoimmune haemolytic anaemia 318.33 13.52 145 58899 8235 79677109
Graft versus host disease 299.41 13.52 168 58876 14858 79670486
Blood thyroid stimulating hormone decreased 292.43 13.52 122 58922 5594 79679750
Bacterial test positive 289.61 13.52 131 58913 7318 79678026
Epstein-Barr virus infection 278.64 13.52 158 58886 14258 79671086
Urine ketone body present 277.13 13.52 103 58941 3462 79681882
Bacterial test 274.98 13.52 79 58965 1144 79684200
Autoimmune thyroiditis 266.94 13.52 105 58939 4128 79681216
Graft versus host disease in skin 252.70 13.52 112 58932 5961 79679383
Acute graft versus host disease in skin 252.06 13.52 120 58924 7538 79677806
Nitrite urine present 244.83 13.52 72 58972 1137 79684207
Monocyte percentage increased 243.21 13.52 82 58962 2059 79683285
Red cell distribution width increased 239.21 13.52 146 58898 15096 79670248
Transplant failure 220.54 13.52 94 58950 4547 79680797
Blood thyroid stimulating hormone increased 202.84 13.52 112 58932 9596 79675748
Pyrexia 200.48 13.52 1011 58033 677698 79007646
Flushing 200.47 13.52 285 58759 87983 79597361
Hyperthyroidism 193.79 13.52 148 58896 22061 79663283
Drug interaction 186.44 13.52 40 59004 415143 79270201
Haemoglobin urine present 176.53 13.52 53 58991 902 79684442
Headache 176.46 13.52 950 58094 652822 79032522
Product dose omission issue 168.22 13.52 3 59041 247534 79437810
Herpes simplex 166.72 13.52 107 58937 12080 79673264
Haematocrit decreased 166.57 13.52 216 58828 61096 79624248
Completed suicide 162.97 13.52 4 59040 245763 79439581
Magnetic resonance imaging abnormal 160.86 13.52 69 58975 3390 79681954
Graft versus host disease in gastrointestinal tract 159.97 13.52 83 58961 6273 79679071
Culture urine positive 159.84 13.52 74 58970 4361 79680983
Specific gravity urine decreased 154.87 13.52 47 58997 831 79684513
Cytomegalovirus viraemia 152.14 13.52 103 58941 12718 79672626
White blood cell count decreased 147.03 13.52 386 58658 187902 79497442
Transplant rejection 146.87 13.52 119 58925 19318 79666026
Protein urine present 146.34 13.52 92 58952 10020 79675324
Microsporidia infection 146.27 13.52 46 58998 920 79684424
Leukocyturia 145.77 13.52 55 58989 1928 79683416
Thyroxine free increased 143.16 13.52 48 58996 1184 79684160
Progressive multifocal leukoencephalopathy 138.76 13.52 118 58926 20482 79664862
Cytomegalovirus infection reactivation 135.50 13.52 83 58961 8633 79676711
BK virus infection 134.74 13.52 83 58961 8721 79676623
Drug hypersensitivity 133.70 13.52 29 59015 298887 79386457
Platelet count decreased 130.08 13.52 377 58667 194287 79491057
Toxicity to various agents 123.67 13.52 80 58964 421460 79263884
End stage renal disease 123.57 13.52 89 58955 12131 79673213
Chest discomfort 122.34 13.52 297 58747 137747 79547597
Drug intolerance 121.46 13.52 24 59020 264095 79421249
Monocyte count decreased 120.34 13.52 55 58989 3146 79682198
Anti-thyroid antibody positive 119.99 13.52 34 59010 467 79684877
Rheumatoid arthritis 119.96 13.52 9 59035 208461 79476883
JC virus infection 119.18 13.52 58 58986 3823 79681521
Overdose 118.42 13.52 4 59040 184202 79501142
Human herpesvirus 6 infection 115.07 13.52 63 58981 5307 79680037
Mean cell haemoglobin decreased 111.66 13.52 65 58979 6159 79679185
Endocrine ophthalmopathy 111.62 13.52 35 59009 693 79684651
CD4 lymphocytes decreased 110.94 13.52 49 58995 2585 79682759
Chronic graft versus host disease in skin 109.73 13.52 42 59002 1532 79683812
Epstein-Barr viraemia 109.22 13.52 46 58998 2159 79683185
Drug abuse 106.50 13.52 3 59041 162688 79522656
Specific gravity urine increased 104.31 13.52 30 59014 436 79684908
Death 102.95 13.52 163 58881 566351 79118993
Acute graft versus host disease 102.69 13.52 74 58970 10093 79675251
Arthropathy 100.89 13.52 8 59036 177103 79508241
Herpes zoster 98.71 13.52 215 58829 92868 79592476
Synovitis 97.86 13.52 3 59041 150731 79534613
Joint swelling 97.30 13.52 46 58998 288600 79396744
Neutrophil count increased 96.61 13.52 114 58930 29282 79656062
Epstein-Barr virus infection reactivation 95.49 13.52 40 59004 1852 79683492
Diarrhoea 95.42 13.52 334 58710 880155 78805189
Urinary casts 93.94 13.52 35 59009 1184 79684160
Drug monitoring procedure not performed 92.70 13.52 33 59011 978 79684366
Feeling hot 92.66 13.52 162 58882 59572 79625772
Varicella zoster virus infection 89.39 13.52 50 58994 4391 79680953
Eosinophil percentage increased 86.48 13.52 35 59009 1483 79683861
Acute graft versus host disease in intestine 85.46 13.52 47 58997 3994 79681350
Bradycardia 84.27 13.52 256 58788 135301 79550043
Lymphocyte count abnormal 83.38 13.52 34 59010 1469 79683875
Mean cell haemoglobin concentration decreased 82.62 13.52 48 58996 4531 79680813
Monocyte count increased 82.08 13.52 66 58978 10595 79674749
Chronic graft versus host disease 81.70 13.52 55 58989 6726 79678618
Chronic graft versus host disease in liver 81.54 13.52 27 59017 640 79684704
Infusion site pain 81.06 13.52 74 58970 14102 79671242
Autoimmune neutropenia 80.21 13.52 26 59018 575 79684769
Fall 79.67 13.52 150 58894 487479 79197865
Mucoepidermoid carcinoma of salivary gland 79.42 13.52 18 59026 91 79685253
Leukopenia 79.06 13.52 227 58817 116286 79569058
pH urine increased 78.88 13.52 24 59020 428 79684916
Red blood cell count increased 78.29 13.52 45 58999 4163 79681181
Urobilinogen urine increased 76.95 13.52 26 59018 657 79684687
Systemic lupus erythematosus 76.57 13.52 3 59041 121146 79564198
Body temperature increased 76.20 13.52 126 58918 44294 79641050
Red blood cells urine 75.85 13.52 26 59018 687 79684657
Red blood cell count decreased 74.11 13.52 144 58900 57369 79627975
Heavy menstrual bleeding 74.05 13.52 70 58974 13941 79671403
Viraemia 73.73 13.52 38 59006 2831 79682513
Band sensation 73.31 13.52 26 59018 762 79684582
Arthralgia 73.06 13.52 201 58843 571602 79113742
Tachycardia 72.51 13.52 292 58752 177476 79507868
Petechiae 71.33 13.52 82 58962 20483 79664861
Bilirubin urine present 71.15 13.52 21 59023 336 79685008
Myocardial infarction 70.75 13.52 24 59020 184105 79501239
Red cell distribution width decreased 70.33 13.52 33 59011 2005 79683339
Chills 70.04 13.52 269 58775 159965 79525379
Graft loss 69.74 13.52 27 59017 1016 79684328
Eosinophil count increased 69.32 13.52 74 58970 17031 79668313
Multiple organ dysfunction syndrome 69.11 13.52 221 58823 120025 79565319
Mean cell volume decreased 69.06 13.52 44 59000 4903 79680441
Pain 68.93 13.52 278 58766 703524 78981820
Blood thyroid stimulating hormone abnormal 68.30 13.52 26 59018 934 79684410
Autoimmune disorder 67.56 13.52 72 58972 16540 79668804
Band neutrophil percentage increased 67.34 13.52 21 59023 408 79684936
Drug ineffective 67.33 13.52 497 58547 1080416 78604928
CD4 lymphocytes abnormal 67.06 13.52 14 59030 44 79685300
Cells in urine 66.54 13.52 18 59026 206 79685138
Pneumonia cytomegaloviral 66.41 13.52 43 59001 4926 79680418
Muscular weakness 65.53 13.52 264 58780 160465 79524879
Confusional state 65.07 13.52 84 58960 317913 79367431
Bacteriuria 64.57 13.52 27 59017 1244 79684100
Thrombotic microangiopathy 64.26 13.52 77 58967 20092 79665252
Listeriosis 64.25 13.52 32 59012 2218 79683126
Thyroid stimulating immunoglobulin 63.85 13.52 14 59030 59 79685285
Polyomavirus viraemia 63.13 13.52 29 59015 1678 79683666
Poor quality sleep 61.60 13.52 80 58964 22642 79662702
Injection site pain 61.35 13.52 11 59033 129827 79555517
Urticaria 60.82 13.52 285 58759 184916 79500428
Glossodynia 60.75 13.52 4 59040 103333 79582011
Rhabdomyolysis 60.61 13.52 4 59040 103127 79582217
Atrial fibrillation 60.09 13.52 36 59008 197850 79487494
Haemolytic anaemia 60.03 13.52 70 58974 17750 79667594
Mucosal inflammation 59.98 13.52 156 58888 75424 79609920
Multiple sclerosis 59.70 13.52 78 58966 22204 79663140
Urine leukocyte esterase 58.99 13.52 16 59028 185 79685159
Menstruation irregular 58.65 13.52 40 59004 4996 79680348
Hypothyroidism 57.79 13.52 123 58921 52269 79633075
Venoocclusive disease 57.28 13.52 38 59006 4535 79680809
Diffuse large B-cell lymphoma 57.26 13.52 57 58987 12092 79673252
Swelling 57.10 13.52 46 58998 216665 79468679
Wound 56.76 13.52 9 59035 116170 79569174
Hypoglycaemia 56.71 13.52 5 59039 101589 79583755
Bronchopulmonary aspergillosis 56.59 13.52 76 58968 22218 79663126
Maternal exposure during pregnancy 55.66 13.52 16 59028 136522 79548822
Blood creatinine decreased 55.11 13.52 46 58998 7779 79677565
Acute kidney injury 54.76 13.52 199 58845 519205 79166139
Tri-iodothyronine free increased 54.56 13.52 16 59028 250 79685094
Band neutrophil count increased 53.86 13.52 20 59024 670 79684674
Chronic graft versus host disease in intestine 53.68 13.52 17 59027 348 79684996
Oedema peripheral 53.31 13.52 65 58979 252223 79433121
Hyponatraemia 53.10 13.52 33 59011 177815 79507529
Tri-iodothyronine free decreased 53.01 13.52 17 59027 363 79684981
Cystitis viral 52.82 13.52 20 59024 708 79684636
Acute myeloid leukaemia recurrent 52.03 13.52 32 59012 3351 79681993
Thyroxine free decreased 51.98 13.52 22 59022 1045 79684299
Meningitis listeria 51.94 13.52 22 59022 1047 79684297
Haemophagocytic lymphohistiocytosis 51.73 13.52 72 58972 21765 79663579
Autoimmune thyroid disorder 51.24 13.52 11 59033 41 79685303
Aspergillus infection 51.22 13.52 67 58977 19094 79666250
Epstein-Barr virus associated lymphoproliferative disorder 50.76 13.52 32 59012 3500 79681844
Meningitis viral 50.14 13.52 26 59018 1962 79683382
Autoimmune hypothyroidism 49.49 13.52 15 59029 264 79685080
Mean cell haemoglobin concentration increased 48.64 13.52 20 59024 883 79684461
Therapeutic product effect incomplete 48.58 13.52 22 59022 141623 79543721
Monocyte percentage decreased 48.07 13.52 15 59029 292 79685052
White blood cells urine 48.00 13.52 17 59027 496 79684848
Toxoplasmosis 47.94 13.52 28 59016 2669 79682675
Eosinophil percentage decreased 47.83 13.52 15 59029 297 79685047
Acute disseminated encephalomyelitis 47.79 13.52 15 59029 298 79685046
Arthritis 47.68 13.52 13 59031 114867 79570477
Pyelonephritis fungal 47.37 13.52 14 59030 225 79685119
Propionibacterium infection 47.14 13.52 15 59029 312 79685032
Cystitis haemorrhagic 46.90 13.52 45 58999 9127 79676217
Thyroid function test abnormal 46.57 13.52 29 59015 3105 79682239
Platelet count abnormal 45.95 13.52 34 59010 4828 79680516
Anaemia 45.90 13.52 172 58872 444843 79240501
Central nervous system lesion 45.85 13.52 53 58991 13315 79672029
Peripheral swelling 45.69 13.52 81 58963 269536 79415808
Mycobacterium kansasii infection 45.64 13.52 15 59029 347 79684997
Urinary tract infection bacterial 45.57 13.52 38 59006 6418 79678926
Hepatic enzyme increased 45.36 13.52 41 59003 182569 79502775
Neuropathy peripheral 45.34 13.52 24 59020 141281 79544063
Hypersensitivity 45.14 13.52 78 58966 262161 79423183
Haematocrit increased 44.53 13.52 31 59013 4003 79681341
Osteoarthritis 44.41 13.52 6 59038 87303 79598041
Menstrual disorder 44.30 13.52 31 59013 4036 79681308
Product use in unapproved indication 44.15 13.52 327 58717 250032 79435312
Optic neuritis 43.64 13.52 44 59000 9476 79675868
Alopecia 43.41 13.52 65 58979 231290 79454054
Urinary tract infection 43.11 13.52 349 58695 274163 79411181
Systemic mycosis 43.01 13.52 26 59018 2640 79682704
T-lymphocyte count decreased 42.67 13.52 16 59028 551 79684793
Urine oxalate increased 42.51 13.52 13 59031 236 79685108
Impaired healing 42.34 13.52 7 59037 87648 79597696
Product use issue 42.30 13.52 56 58988 209766 79475578
Oropharyngeal pain 41.70 13.52 176 58868 109177 79576167
Granulocyte percentage 41.47 13.52 10 59034 69 79685275
Myelocyte count increased 41.31 13.52 17 59027 752 79684592
Central nervous system lymphoma 41.31 13.52 24 59020 2265 79683079
Gastroenteritis adenovirus 40.95 13.52 14 59030 367 79684977
Venoocclusive liver disease 40.93 13.52 47 58997 11724 79673620
Chronic obstructive pulmonary disease 40.87 13.52 7 59037 85412 79599932
Adenovirus reactivation 40.66 13.52 14 59030 375 79684969
Mean cell haemoglobin increased 40.58 13.52 30 59014 4255 79681089
International normalised ratio increased 40.41 13.52 7 59037 84714 79600630
Insomnia 40.30 13.52 315 58729 244855 79440489
Lipaemic index score 40.26 13.52 11 59033 131 79685213
Neutrophil percentage decreased 39.69 13.52 17 59027 832 79684512
Pathogen resistance 39.66 13.52 51 58993 14291 79671053
Pseudomonas infection 39.54 13.52 62 58982 20841 79664503
Cardiac failure 39.38 13.52 34 59010 154808 79530536
Suicide attempt 39.23 13.52 7 59037 82925 79602419
Human polyomavirus infection 38.44 13.52 18 59026 1088 79684256
Cerebrovascular accident 38.41 13.52 35 59009 155257 79530087
Depressed level of consciousness 38.17 13.52 12 59032 96640 79588704
Myelocyte percentage increased 38.06 13.52 12 59032 242 79685102
Injury 37.85 13.52 6 59038 77490 79607854
Enterococcal infection 37.64 13.52 52 58992 15608 79669736
Creatinine urine decreased 37.60 13.52 12 59032 252 79685092
Lymphoproliferative disorder 37.47 13.52 32 59012 5583 79679761
Parainfluenzae virus infection 37.14 13.52 32 59012 5650 79679694
Pulmonary haemorrhage 37.09 13.52 50 58994 14667 79670677
Feeling cold 37.08 13.52 72 58972 28657 79656687
Treatment failure 36.98 13.52 43 59001 170443 79514901
Bone marrow transplant rejection 36.95 13.52 12 59032 267 79685077
Haemoglobin decreased 36.84 13.52 286 58758 221833 79463511
Fibromyalgia 36.36 13.52 3 59041 64337 79621007
Lymphadenopathy 36.34 13.52 104 58940 53143 79632201
Exophthalmos 36.25 13.52 20 59024 1710 79683634
Gingival bleeding 36.09 13.52 52 58992 16224 79669120
Psoriasis 35.59 13.52 11 59033 89576 79595768
Blood pressure systolic increased 35.55 13.52 4 59040 66982 79618362
Nocardiosis 35.14 13.52 31 59013 5648 79679696
Decreased appetite 34.85 13.52 133 58911 342285 79343059
Crystalluria 34.68 13.52 16 59028 935 79684409
Leukaemia recurrent 34.62 13.52 23 59021 2751 79682593
Urine bilirubin decreased 34.60 13.52 10 59034 148 79685196
Gastroenteritis norovirus 34.59 13.52 24 59020 3082 79682262
Listeria sepsis 34.58 13.52 15 59029 757 79684587
Infusion site extravasation 34.54 13.52 40 59004 10068 79675276
Coronary artery disease 34.52 13.52 4 59040 65470 79619874
Neutropenia 34.51 13.52 345 58699 287365 79397979
Mean platelet volume decreased 34.50 13.52 23 59021 2767 79682577
Hyperkalaemia 34.45 13.52 21 59023 114377 79570967
Immature granulocyte count increased 34.40 13.52 14 59030 602 79684742
Meningitis tuberculous 34.00 13.52 17 59027 1188 79684156
Thrombotic thrombocytopenic purpura 33.97 13.52 32 59012 6344 79679000
Chronic lymphocytic leukaemia transformation 33.45 13.52 11 59033 255 79685089
Acute myocardial infarction 33.35 13.52 8 59036 77028 79608316
Dehydration 33.31 13.52 85 58959 248102 79437242
Glucose urine present 33.26 13.52 19 59025 1737 79683607
Syncope 33.09 13.52 51 58993 179398 79505946
Incorrect dose administered 33.09 13.52 8 59036 76622 79608722
Pulmonary nocardiosis 32.64 13.52 17 59027 1294 79684050
Cardiac arrest 32.61 13.52 48 58996 172048 79513296
Basophil percentage increased 32.52 13.52 10 59034 185 79685159
Monocyte count abnormal 32.42 13.52 10 59034 187 79685157
Bacterial sepsis 32.40 13.52 35 59009 8163 79677181
Normocytic anaemia 32.29 13.52 26 59018 4181 79681163
Mean platelet volume increased 32.19 13.52 16 59028 1104 79684240
Oral herpes 32.07 13.52 66 58978 27388 79657956
Rotavirus infection 31.88 13.52 14 59030 728 79684616
Neutrophil count decreased 31.85 13.52 146 58898 93813 79591531
Anogenital warts 31.85 13.52 15 59029 919 79684425
Listeria test positive 31.76 13.52 6 59038 9 79685335
Vomiting 31.57 13.52 328 58716 665500 79019844
Acute graft versus host disease in liver 31.55 13.52 19 59025 1916 79683428
B-lymphocyte count decreased 31.43 13.52 17 59027 1397 79683947
Idiopathic pneumonia syndrome 31.42 13.52 13 59031 583 79684761
Autoimmune pancytopenia 31.34 13.52 10 59034 210 79685134
Drug reaction with eosinophilia and systemic symptoms 31.32 13.52 5 59039 64239 79621105
Pneumocystis jirovecii pneumonia 30.98 13.52 72 58972 32436 79652908
Hypoaesthesia 30.88 13.52 233 58811 179119 79506225
Orthostatic hypotension 30.71 13.52 3 59041 56161 79629183
Mean cell volume increased 30.70 13.52 30 59014 6223 79679121
Drug exposure before pregnancy 30.69 13.52 13 59031 619 79684725
Adverse drug reaction 30.55 13.52 6 59038 66386 79618958
Limb discomfort 30.48 13.52 72 58972 32778 79652566
Injection site erythema 30.36 13.52 10 59034 78187 79607157
Immature granulocyte percentage increased 30.28 13.52 8 59036 83 79685261
Factor VIII deficiency 30.15 13.52 9 59035 150 79685194
Cardiac disorder 30.14 13.52 6 59038 65751 79619593
Cytomegalovirus test positive 30.07 13.52 29 59015 5918 79679426
Pancytopenia 30.06 13.52 218 58826 165527 79519817
CD4 lymphocyte percentage decreased 30.04 13.52 6 59038 14 79685330
Acanthamoeba infection 30.00 13.52 12 59032 493 79684851
Irritable bowel syndrome 29.99 13.52 5 59039 62236 79623108
Thyroid stimulating immunoglobulin increased 29.94 13.52 8 59036 87 79685257
Fusarium infection 29.90 13.52 18 59026 1814 79683530
Cardio-respiratory arrest 29.88 13.52 22 59022 108488 79576856
Metabolic acidosis 29.59 13.52 12 59032 82517 79602827
Heart rate increased 29.37 13.52 171 58873 120553 79564791
Haemoglobin increased 29.32 13.52 29 59015 6103 79679241
Rectal haemorrhage 29.20 13.52 10 59034 76290 79609054
Gastrointestinal haemorrhage 29.18 13.52 40 59004 147679 79537665
Graft versus host disease in lung 29.12 13.52 14 59030 898 79684446
Varicella 28.83 13.52 21 59023 2911 79682433
Laboratory test abnormal 28.82 13.52 64 58980 27984 79657360
Stomatitis 28.73 13.52 40 59004 146717 79538627
Plasma cell myeloma 28.72 13.52 3 59041 53256 79632088
Anaphylactic reaction 28.72 13.52 13 59031 83730 79601614
Adverse event 28.66 13.52 5 59039 60209 79625135
Gastrointestinal disorder 28.52 13.52 29 59015 122176 79563168
Human herpesvirus 6 infection reactivation 28.49 13.52 12 59032 563 79684781
Aplastic anaemia 28.33 13.52 49 58995 17856 79667488
Thyroiditis 28.22 13.52 25 59019 4580 79680764
Polymyositis 28.18 13.52 21 59023 3015 79682329
Electrocardiogram QT prolonged 28.05 13.52 16 59028 90370 79594974
Discomfort 27.98 13.52 31 59013 125586 79559758
Enterococcal bacteraemia 27.98 13.52 21 59023 3047 79682297
Sedation 27.78 13.52 3 59041 51892 79633452
Herpes virus infection 27.69 13.52 30 59014 7019 79678325
Red blood cell elliptocytes present 27.60 13.52 9 59035 203 79685141
Vitiligo 27.57 13.52 18 59026 2091 79683253
B-cell lymphoma 27.17 13.52 28 59016 6187 79679157
Aggression 27.15 13.52 3 59041 50955 79634389
Staphylococcal bacteraemia 27.04 13.52 39 59005 12179 79673165
Chronic hepatitis C 27.02 13.52 12 59032 641 79684703
Expanded disability status scale score increased 26.88 13.52 12 59032 649 79684695
Encephalitis 26.84 13.52 43 59001 14717 79670627
Loss of personal independence in daily activities 26.72 13.52 22 59022 102558 79582786
Proteinuria 26.72 13.52 68 58976 32434 79652910
Malignant neoplasm progression 26.68 13.52 37 59007 135953 79549391
Type 2 diabetes mellitus 26.63 13.52 5 59039 57117 79628227
Intentional product misuse 26.58 13.52 19 59025 95146 79590198
Pericarditis 26.36 13.52 23 59021 104213 79581131
Pneumonia 26.32 13.52 338 58706 659908 79025436
B-lymphocyte count increased 26.28 13.52 8 59036 143 79685201
Constipation 26.24 13.52 114 58930 282936 79402408
Infertility 26.21 13.52 12 59032 689 79684655
Eosinophil count decreased 26.09 13.52 21 59023 3375 79681969
Temperature intolerance 26.04 13.52 34 59010 9671 79675673
Hepatitis infectious mononucleosis 25.92 13.52 8 59036 150 79685194
Angioedema 25.77 13.52 12 59032 76023 79609321
Lactobacillus infection 25.64 13.52 10 59034 384 79684960
Treatment noncompliance 25.63 13.52 4 59040 52264 79633080
Quadriparesis 25.53 13.52 21 59023 3480 79681864
Viral haemorrhagic cystitis 25.51 13.52 17 59027 2044 79683300
Intentional product use issue 25.47 13.52 46 58998 152066 79533278
White blood cell count abnormal 25.33 13.52 26 59018 5719 79679625
Creatinine urine increased 25.31 13.52 11 59033 558 79684786
Herpes zoster meningoencephalitis 25.27 13.52 12 59032 749 79684595
Basophil count increased 25.13 13.52 15 59029 1488 79683856
Delirium 24.84 13.52 16 59028 84611 79600733
Anti-glomerular basement membrane antibody positive 24.84 13.52 4 59040 0 79685344
Goodpasture's syndrome 24.84 13.52 4 59040 0 79685344
Anti-glomerular basement membrane antibody 24.84 13.52 4 59040 0 79685344
Embryonal rhabdomyosarcoma 24.81 13.52 6 59038 42 79685302
Drug-induced liver injury 24.73 13.52 9 59035 66108 79619236
Blood creatine phosphokinase increased 24.71 13.52 9 59035 66081 79619263
Mycobacterial infection 24.67 13.52 21 59023 3647 79681697
Hypokalaemia 24.63 13.52 43 59001 143997 79541347
Pollakiuria 24.61 13.52 72 58972 37245 79648099
Legionella infection 24.56 13.52 12 59032 798 79684546
Vulvovaginal mycotic infection 24.48 13.52 23 59021 4543 79680801
Thrombocytopenia 24.44 13.52 302 58742 264957 79420387
Hypomagnesaemia 24.40 13.52 3 59041 46908 79638436
Encephalitis viral 24.30 13.52 18 59026 2561 79682783
Fungal skin infection 24.26 13.52 26 59018 6010 79679334
Stenotrophomonas infection 24.16 13.52 21 59023 3752 79681592
Hypocalcaemia 24.08 13.52 4 59040 49920 79635424
Lactic acidosis 24.00 13.52 11 59033 70348 79614996
Epstein-Barr virus associated lymphoma 23.95 13.52 13 59031 1076 79684268
Rash 23.77 13.52 578 58466 577780 79107564
Transient ischaemic attack 23.75 13.52 5 59039 52690 79632654
Diplopia 23.45 13.52 66 58978 33400 79651944
Asthma 23.40 13.52 40 59004 135055 79550289
Immune reconstitution inflammatory syndrome 23.38 13.52 39 59005 13802 79671542
Activated partial thromboplastin time shortened 23.37 13.52 12 59032 887 79684457
Throat irritation 23.27 13.52 75 58969 40871 79644473
Parvovirus infection 23.23 13.52 11 59033 682 79684662
Abdominal discomfort 23.22 13.52 101 58943 250626 79434718
Anti-glomerular basement membrane disease 23.19 13.52 6 59038 57 79685287
Papilloma viral infection 23.16 13.52 15 59029 1719 79683625
Pneumonia adenoviral 23.11 13.52 10 59034 502 79684842
Oedema 23.00 13.52 33 59011 119547 79565797
Product prescribing error 22.98 13.52 3 59041 44810 79640534
Vaginal discharge 22.97 13.52 28 59016 7435 79677909
Apoptosis 22.96 13.52 10 59034 510 79684834
Pulmonary embolism 22.86 13.52 59 58985 171595 79513749
Contusion 22.70 13.52 188 58856 148588 79536756
Eosinophil count abnormal 22.39 13.52 11 59033 740 79684604
Altered state of consciousness 22.31 13.52 3 59041 43819 79641525
Tuberculosis liver 22.15 13.52 6 59038 69 79685275
Growth failure 22.13 13.52 8 59036 248 79685096
Urine bilirubin increased 22.07 13.52 7 59037 144 79685200
Muscle spasticity 22.06 13.52 49 58995 21426 79663918
Aplasia pure red cell 21.95 13.52 28 59016 7782 79677562
Granulocyte count increased 21.94 13.52 13 59031 1272 79684072
Drug resistance 21.92 13.52 75 58969 42138 79643206
Pregnancy of partner 21.86 13.52 8 59036 257 79685087
Acquired haemophilia 21.83 13.52 15 59029 1896 79683448
Pulmonary alveolar haemorrhage 21.69 13.52 34 59010 11423 79673921
Haemoglobin urine 21.54 13.52 7 59037 156 79685188
Weight increased 21.50 13.52 119 58925 277267 79408077
Atypical mycobacterial pneumonia 21.26 13.52 7 59037 163 79685181
Respiratory arrest 21.24 13.52 8 59036 57542 79627802
Infection in an immunocompromised host 21.19 13.52 13 59031 1355 79683989
Evans syndrome 21.18 13.52 9 59035 432 79684912
Infusion site discomfort 21.03 13.52 13 59031 1374 79683970
Musculoskeletal pain 20.94 13.52 27 59017 102327 79583017
Complications of bone marrow transplant 20.88 13.52 10 59034 636 79684708
Chronic lymphocytic leukaemia recurrent 20.85 13.52 10 59034 638 79684706
Goitre 20.76 13.52 23 59021 5516 79679828
Deep vein thrombosis 20.76 13.52 36 59008 120883 79564461
Lymphocyte percentage abnormal 20.67 13.52 5 59039 35 79685309
Klebsiella sepsis 20.62 13.52 18 59026 3234 79682110
Graft versus host disease in liver 20.59 13.52 14 59030 1740 79683604
Retinal depigmentation 20.27 13.52 8 59036 317 79685027
Pulmonary fibrosis 20.27 13.52 4 59040 44108 79641236
Blister 20.12 13.52 36 59008 119440 79565904
Actinomycotic sepsis 20.04 13.52 6 59038 101 79685243
Tri-iodothyronine free abnormal 19.98 13.52 5 59039 41 79685303
Hypotension 19.98 13.52 219 58825 440098 79245246
Engraft failure 19.94 13.52 10 59034 703 79684641
Folliculitis 19.94 13.52 8 59036 55372 79629972
Candida infection 19.93 13.52 68 58976 38146 79647198
Meningism 19.93 13.52 10 59034 704 79684640
Microangiopathy 19.81 13.52 14 59030 1851 79683493
Varicella virus test positive 19.81 13.52 7 59037 203 79685141
Bronchitis 19.72 13.52 42 59002 130602 79554742
Fibrin D dimer increased 19.70 13.52 28 59016 8626 79676718
Injection site reaction 19.59 13.52 8 59036 54777 79630567
Posterior reversible encephalopathy syndrome 19.57 13.52 53 58991 26228 79659116
Albuminuria 19.48 13.52 10 59034 739 79684605
Accidental overdose 19.48 13.52 3 59041 39578 79645766
T-cell prolymphocytic leukaemia 19.47 13.52 5 59039 46 79685298
Anti-thyroid antibody 19.47 13.52 5 59039 46 79685298
Infusion site scar 19.42 13.52 8 59036 355 79684989
Urine uric acid increased 19.37 13.52 5 59039 47 79685297
Hallucination 19.27 13.52 21 59023 85724 79599620
Chromaturia 19.25 13.52 52 58992 25694 79659650
C-reactive protein abnormal 19.10 13.52 6 59038 48361 79636983
Chronic lymphocytic leukaemia refractory 19.08 13.52 6 59038 120 79685224
Diabetes mellitus 18.98 13.52 18 59026 78372 79606972
Sinus bradycardia 18.89 13.52 51 58993 25196 79660148
Myositis 18.87 13.52 43 59001 19125 79666219
Chronic kidney disease 18.75 13.52 13 59031 66141 79619203
Interleukin-2 receptor increased 18.62 13.52 7 59037 243 79685101
Loefgren syndrome 18.37 13.52 6 59038 136 79685208
Viral test positive 18.37 13.52 8 59036 408 79684936
Erythema 18.36 13.52 249 58795 223041 79462303
Fumbling 18.33 13.52 6 59038 137 79685207
Dyspnoea 18.32 13.52 489 58555 856536 78828808
Coma 18.17 13.52 29 59015 100620 79584724
Pneumonia fungal 18.15 13.52 31 59013 11179 79674165
Fungal infection 18.14 13.52 70 58974 41678 79643666
Leukaemic infiltration 18.13 13.52 6 59038 142 79685202
Herpes zoster infection neurological 18.07 13.52 7 59037 264 79685080
Nitrite urine 18.03 13.52 4 59040 18 79685326
Condition aggravated 17.97 13.52 262 58782 500862 79184482
Suicidal ideation 17.94 13.52 18 59026 76322 79609022
Pneumonia pseudomonal 17.90 13.52 22 59022 5889 79679455
Cataract 17.88 13.52 12 59032 62108 79623236
Glomerulonephritis chronic 17.87 13.52 7 59037 272 79685072
Enterobacter bacteraemia 17.84 13.52 10 59034 882 79684462
Thyroid disorder 17.82 13.52 35 59009 14044 79671300
Neoplasm progression 17.75 13.52 8 59036 51674 79633670
Splenomegaly 17.66 13.52 44 59000 20710 79664634
Osteoporosis 17.63 13.52 9 59035 54103 79631241
Post herpetic neuralgia 17.62 13.52 15 59029 2606 79682738
Platelet morphology abnormal 17.56 13.52 6 59038 157 79685187
Paternal exposure timing unspecified 17.49 13.52 5 59039 71 79685273
Bladder dysfunction 17.47 13.52 11 59033 1201 79684143
Exposure during pregnancy 17.46 13.52 30 59014 101102 79584242
Thrombosis 17.39 13.52 22 59022 84078 79601266
Protein urine 17.37 13.52 12 59032 1530 79683814
Urobilinogen urine 17.37 13.52 4 59040 22 79685322
Gait disturbance 17.31 13.52 232 58812 207274 79478070
Injection site pruritus 17.14 13.52 5 59039 42278 79643066
Citrobacter infection 17.06 13.52 10 59034 960 79684384
Glomerulonephropathy 16.96 13.52 7 59037 312 79685032
Diarrhoea haemorrhagic 16.87 13.52 33 59011 13201 79672143
Lymphocyte percentage increased 16.87 13.52 9 59035 720 79684624
Urine odour abnormal 16.86 13.52 22 59022 6251 79679093
Nystagmus 16.85 13.52 28 59016 9876 79675468
Pancreas transplant rejection 16.83 13.52 7 59037 318 79685026
Neutrophil percentage abnormal 16.80 13.52 4 59040 26 79685318
General physical health deterioration 16.78 13.52 127 58917 275111 79410233
Weight decreased 16.77 13.52 175 58869 355023 79330321
Stem cell transplant 16.76 13.52 17 59027 3687 79681657
Femur fracture 16.75 13.52 4 59040 38648 79646696
Blood pressure fluctuation 16.75 13.52 15 59029 67130 79618214
Pneumonia aspiration 16.66 13.52 15 59029 66952 79618392
Injection site swelling 16.66 13.52 7 59037 47125 79638219
Thyroid hormones increased 16.60 13.52 8 59036 516 79684828
Loss of consciousness 16.57 13.52 66 58978 167877 79517467
Monocyte percentage abnormal 16.55 13.52 3 59041 3 79685341
Basophil count abnormal 16.54 13.52 4 59040 28 79685316
Thyroiditis subacute 16.53 13.52 7 59037 333 79685011
Blood stem cell transplant failure 16.44 13.52 8 59036 527 79684817
Skin papilloma 16.38 13.52 21 59023 5865 79679479
Ureaplasma infection 16.32 13.52 10 59034 1040 79684304
Chronic lymphocytic leukaemia 16.20 13.52 19 59025 4847 79680497
Shock 16.16 13.52 6 59038 43542 79641802
Infusion related reaction 16.12 13.52 102 58942 230135 79455209
Sleep disorder 16.12 13.52 24 59020 85653 79599691
Poikilocytosis 16.07 13.52 7 59037 357 79684987
Therapy cessation 16.06 13.52 4 59040 37558 79647786
Cytomegalovirus chorioretinitis 15.93 13.52 20 59024 5470 79679874
Melaena 15.93 13.52 13 59031 60877 79624467
Infusion site swelling 15.91 13.52 24 59020 7802 79677542
Disorder of globe 15.69 13.52 3 59041 5 79685339
Periportal oedema 15.67 13.52 5 59039 105 79685239
Dysgraphia 15.56 13.52 17 59027 4015 79681329
Malignant melanoma 15.55 13.52 34 59010 14707 79670637
Interstitial lung disease 15.53 13.52 38 59006 112562 79572782
Inappropriate schedule of product administration 15.53 13.52 49 58995 133579 79551765
Hot flush 15.53 13.52 81 58963 54796 79630548
Micturition urgency 15.49 13.52 31 59013 12610 79672734
Infection reactivation 15.44 13.52 14 59030 2643 79682701
Transfusion microchimerism 15.34 13.52 3 59041 6 79685338
Eosinophil percentage abnormal 15.34 13.52 3 59041 6 79685338
Thyroid cyst 15.32 13.52 7 59037 400 79684944
Dyskinesia 15.27 13.52 7 59037 44766 79640578
Hepatic function abnormal 15.25 13.52 19 59025 73088 79612256
Ventricular tachycardia 15.19 13.52 6 59038 41929 79643415
Endometrial ablation 15.16 13.52 9 59035 884 79684460
Phaeohyphomycosis 15.12 13.52 10 59034 1187 79684157
Semenuria 15.10 13.52 4 59040 42 79685302
Renal transplant failure 15.09 13.52 12 59032 1895 79683449
Surgery 14.99 13.52 3 59041 32763 79652581
Mycobacterium abscessus infection 14.93 13.52 10 59034 1212 79684132
Liver injury 14.92 13.52 12 59032 56602 79628742
Tri-iodothyronine increased 14.90 13.52 6 59038 251 79685093
Vaccination site inflammation 14.69 13.52 4 59040 47 79685297
JC polyomavirus test positive 14.69 13.52 11 59033 1591 79683753
CD8 lymphocytes decreased 14.63 13.52 6 59038 263 79685081
Paraparesis 14.62 13.52 16 59028 3787 79681557
Obesity 14.52 13.52 4 59040 35121 79650223
Allergy to arthropod bite 14.48 13.52 6 59038 270 79685074
Citric acid urine increased 14.46 13.52 4 59040 50 79685294
Malaise 14.30 13.52 266 58778 489603 79195741
Blood cholesterol increased 14.30 13.52 25 59019 83695 79601649
Colitis ulcerative 14.28 13.52 4 59040 34738 79650606
Intestinal obstruction 14.25 13.52 7 59037 43013 79642331
Increased appetite 14.23 13.52 29 59015 11949 79673395
Obstructive airways disorder 14.15 13.52 3 59041 31456 79653888
Musculoskeletal stiffness 14.15 13.52 74 58970 174934 79510410
Infusion site rash 14.09 13.52 11 59033 1691 79683653
Alopecia universalis 14.04 13.52 6 59038 292 79685052
White blood cell count increased 14.00 13.52 99 58945 74534 79610810
Klebsiella test positive 13.98 13.52 11 59033 1712 79683632
Haemorrhagic cyst 13.87 13.52 6 59038 301 79685043
Cytokine storm 13.85 13.52 9 59035 1037 79684307
Supportive care 13.81 13.52 3 59041 12 79685332
Bilirubin urine 13.81 13.52 3 59041 12 79685332
Pancreatitis acute 13.72 13.52 10 59034 49594 79635750
Raoultella ornithinolytica infection 13.67 13.52 4 59040 62 79685282
Skin ulcer 13.63 13.52 12 59032 54138 79631206
Cardiogenic shock 13.62 13.52 7 59037 41907 79643437
Platelet count increased 13.61 13.52 42 59002 22364 79662980
Hyperoxaluria 13.57 13.52 6 59038 317 79685027

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA34 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
FDA MoA N0000175079 CD52-directed Antibody Interactions
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000074322 Antineoplastic Agents, Immunological
FDA EPC N0000175659 CD52-directed Cytolytic Antibody

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Refractory chronic lymphocytic leukemia indication 92814006
Conditioning treatment prior to allogeneic haematopoietic stem cell transplant indication 234336002
Relapsing remitting multiple sclerosis indication 426373005 DOID:2378
Recurrent chronic lymphocytic leukemia indication 122961000119105




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
CAMPATH-1 antigen Surface antigen ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D02802 KEGG_DRUG
4021265 VUID
N0000148705 NUI
4021265 VANDF
CHEMBL1201587 ChEMBL_ID
6770 IUPHAR_LIGAND_ID
DB00087 DRUGBANK_ID
117055 RXNORM
16025 MMSL
213286 MMSL
41389 MMSL
d04756 MMSL
009168 NDDF
009169 NDDF
129472003 SNOMEDCT_US
391632007 SNOMEDCT_US
C0383429 UMLSCUI
D000074323 MESH_DESCRIPTOR_UI
8005 INN_ID
3A189DH42V UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
LEMTRADA HUMAN PRESCRIPTION DRUG LABEL 1 58468-0200 INJECTION, SOLUTION, CONCENTRATE 12 mg INTRAVENOUS BLA 29 sections
LEMTRADA HUMAN PRESCRIPTION DRUG LABEL 1 58468-0200 INJECTION, SOLUTION, CONCENTRATE 12 mg INTRAVENOUS BLA 29 sections
LEMTRADA HUMAN PRESCRIPTION DRUG LABEL 1 58468-0200 INJECTION, SOLUTION, CONCENTRATE 12 mg INTRAVENOUS BLA 29 sections
LEMTRADA HUMAN PRESCRIPTION DRUG LABEL 1 58468-0200 INJECTION, SOLUTION, CONCENTRATE 12 mg INTRAVENOUS BLA 29 sections
Campath HUMAN PRESCRIPTION DRUG LABEL 1 58468-0357 INJECTION 30 mg INTRAVENOUS BLA 28 sections
Campath HUMAN PRESCRIPTION DRUG LABEL 1 58468-0357 INJECTION 30 mg INTRAVENOUS BLA 28 sections