alemtuzumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4909 216503-57-0

Description:

MoleculeDescription

Synonyms:

  • campath
  • alemtuzumab
  • lemtrada
Alemtuzumab binds to CD52, an antigen present on the surface of B and T lymphocytes, a majority of monocytes, macrophages, NK cells, and a subpopulation of granulocytes. A proportion of bone marrow cells, including some CD34+ cells, express variable levels of CD52. The proposed mechanism of action is antibody-dependent cellular-mediated lysis following cell surface binding of alemtuzumab to the leukemic cells.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.13 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 7, 2001 FDA GENZYME
Sept. 26, 2014 PMDA SANOFI K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lymphocyte count decreased 889.62 14.94 422 37793 25885 50541024
Immune thrombocytopenia 753.54 14.94 276 37939 8741 50558168
Urine abnormality 689.20 14.94 235 37980 6003 50560906
Urinary sediment present 451.48 14.94 130 38085 1861 50565048
White blood cells urine positive 430.62 14.94 153 38062 4425 50562484
Urine leukocyte esterase positive 428.72 14.94 136 38079 2747 50564162
Multiple sclerosis relapse 423.14 14.94 310 37905 42654 50524255
Red blood cells urine positive 413.05 14.94 131 38084 2644 50564265
Lymphocyte percentage decreased 352.48 14.94 116 38099 2644 50564265
Blood urine present 347.24 14.94 177 38038 12656 50554253
Cytomegalovirus infection 338.78 14.94 195 38020 17767 50549142
Crystal urine present 337.59 14.94 97 38118 1377 50565532
Lymphopenia 322.70 14.94 180 38035 15441 50551468
Neutrophil percentage increased 321.86 14.94 108 38107 2619 50564290
Urine analysis abnormal 311.64 14.94 119 38096 4231 50562678
Adenovirus infection 294.61 14.94 105 38110 3063 50563846
Urine ketone body present 246.34 14.94 85 38130 2248 50564661
Bacterial test positive 240.39 14.94 101 38114 4622 50562287
Blood thyroid stimulating hormone decreased 235.27 14.94 96 38119 4076 50562833
Bacterial test 233.40 14.94 69 38146 1088 50565821
Autoimmune thyroiditis 225.07 14.94 87 38128 3198 50563711
Drug ineffective 217.79 14.94 181 38034 819152 49747757
Flushing 215.06 14.94 259 37956 66756 50500153
Red cell distribution width increased 211.22 14.94 111 38104 8448 50558461
Nitrite urine present 207.80 14.94 60 38155 867 50566042
Hyperthyroidism 197.63 14.94 120 38095 12055 50554854
Bradycardia 177.92 14.94 231 37984 64195 50502714
Graft versus host disease in skin 176.20 14.94 68 38147 2488 50564421
Haemoglobin urine present 166.67 14.94 49 38166 757 50566152
Culture urine positive 159.73 14.94 69 38146 3382 50563527
Blood thyroid stimulating hormone increased 158.89 14.94 82 38133 6010 50560899
Leukocyturia 145.99 14.94 47 38168 996 50565913
Pyrexia 145.10 14.94 619 37596 379584 50187325
Protein urine present 144.93 14.94 74 38141 5303 50561606
Headache 142.72 14.94 755 37460 505780 50061129
Mean cell haemoglobin decreased 142.61 14.94 63 38152 3260 50563649
Chest discomfort 142.47 14.94 253 37962 92469 50474440
Haematocrit decreased 138.88 14.94 151 38064 34825 50532084
Monocyte percentage increased 137.94 14.94 45 38170 996 50565913
Rheumatoid arthritis 134.67 14.94 4 38211 202546 50364363
Graft versus host disease 132.63 14.94 73 38142 6093 50560816
Specific gravity urine decreased 130.01 14.94 39 38176 648 50566261
Drug hypersensitivity 129.56 14.94 18 38197 250992 50315917
Thyroxine free increased 128.29 14.94 40 38175 761 50566148
Magnetic resonance imaging abnormal 127.94 14.94 55 38160 2663 50564246
Drug intolerance 127.72 14.94 10 38205 219094 50347815
Neutrophil count increased 125.27 14.94 96 38119 14099 50552810
Product dose omission issue 124.57 14.94 3 38212 183835 50383074
Platelet count decreased 122.74 14.94 249 37966 100477 50466432
White blood cell count decreased 113.05 14.94 263 37952 116459 50450450
Viraemia 112.84 14.94 39 38176 1036 50565873
Monocyte count decreased 111.84 14.94 45 38170 1841 50565068
Anti-thyroid antibody positive 111.68 14.94 31 38184 385 50566524
Drug interaction 103.72 14.94 14 38201 199607 50367302
Death 100.17 14.94 61 38154 325318 50241591
Cytomegalovirus viraemia 99.22 14.94 55 38160 4654 50562255
Tachycardia 96.81 14.94 225 37990 99538 50467371
Monocyte count increased 96.11 14.94 57 38158 5482 50561427
Joint swelling 95.61 14.94 33 38182 245253 50321656
Feeling hot 95.07 14.94 132 38083 39070 50527839
Varicella zoster virus infection 93.50 14.94 43 38172 2446 50564463
Urinary casts 93.30 14.94 30 38185 633 50566276
Contraindicated product administered 92.07 14.94 5 38210 148953 50417956
Systemic lupus erythematosus 89.21 14.94 4 38211 140618 50426291
Mean cell volume decreased 88.19 14.94 42 38173 2587 50564322
Autoimmune haemolytic anaemia 87.81 14.94 48 38167 3951 50562958
Eosinophil count increased 87.45 14.94 64 38151 8766 50558143
Arthropathy 87.15 14.94 9 38206 157897 50409012
Acute graft versus host disease in skin 85.61 14.94 43 38172 2975 50563934
Drug monitoring procedure not performed 85.52 14.94 26 38189 453 50566456
CD4 lymphocytes decreased 83.04 14.94 33 38182 1306 50565603
Endocrine ophthalmopathy 82.97 14.94 24 38191 349 50566560
Infusion site pain 82.52 14.94 71 38144 12275 50554634
Epstein-Barr viraemia 81.31 14.94 29 38186 847 50566062
Toxicity to various agents 80.39 14.94 30 38185 212469 50354440
Synovitis 80.33 14.94 3 38212 123862 50443047
Post transplant lymphoproliferative disorder 80.18 14.94 46 38169 4158 50562751
Red blood cells urine 79.58 14.94 25 38190 488 50566421
Treatment failure 78.18 14.94 7 38208 137630 50429279
Herpes zoster 78.01 14.94 168 38047 70618 50496291
Transplant failure 77.47 14.94 32 38183 1401 50565508
Hypothyroidism 76.96 14.94 111 38104 34014 50532895
Maternal exposure during pregnancy 76.65 14.94 14 38201 159764 50407145
Listeriosis 75.49 14.94 31 38184 1337 50565572
Swelling 74.91 14.94 29 38186 200843 50366066
Red cell distribution width decreased 74.75 14.94 29 38186 1076 50565833
Epstein-Barr virus infection 72.22 14.94 52 38163 6945 50559964
CD4 lymphocytes abnormal 71.60 14.94 12 38203 3 50566906
Pain 70.96 14.94 214 38001 578689 49988220
Autoimmune disorder 70.14 14.94 48 38167 5912 50560997
Urobilinogen urine increased 69.74 14.94 19 38196 219 50566690
Body temperature increased 69.30 14.94 101 38114 31240 50535669
Muscular weakness 68.93 14.94 192 38023 94821 50472088
Growth failure 67.96 14.94 20 38195 310 50566599
Red blood cell count increased 67.41 14.94 35 38180 2596 50564313
Urticaria 65.52 14.94 231 37984 129330 50437579
Heavy menstrual bleeding 65.02 14.94 69 38146 15468 50551441
Diarrhoea 63.52 14.94 230 37985 588246 49978663
Red blood cell count decreased 63.45 14.94 101 38114 33734 50533175
Leukopenia 62.96 14.94 150 38065 67378 50499531
Blood thyroid stimulating hormone abnormal 62.92 14.94 23 38192 722 50566187
Lymphocyte count abnormal 62.83 14.94 22 38193 608 50566301
Overdose 62.71 14.94 3 38212 99724 50467185
Mean cell haemoglobin concentration decreased 61.90 14.94 34 38181 2825 50564084
Tri-iodothyronine free decreased 60.40 14.94 18 38197 292 50566617
Graft versus host disease in gastrointestinal tract 60.01 14.94 33 38182 2748 50564161
Venoocclusive disease 59.69 14.94 29 38186 1867 50565042
Injection site pain 59.54 14.94 7 38208 111017 50455892
Cells in urine 59.33 14.94 16 38199 177 50566732
Fall 58.60 14.94 102 38113 334830 50232079
Petechiae 58.55 14.94 59 38156 12453 50554456
Product use issue 58.38 14.94 20 38195 149455 50417454
Band sensation 57.15 14.94 21 38194 669 50566240
Alopecia 56.56 14.94 61 38154 244986 50321923
Human herpesvirus 6 infection 56.45 14.94 31 38184 2575 50564334
Autoimmune hypothyroidism 55.98 14.94 14 38201 112 50566797
Wound 55.92 14.94 7 38208 105787 50461122
Urine leukocyte esterase 55.23 14.94 14 38201 119 50566790
Blood creatinine decreased 53.70 14.94 38 38177 4938 50561971
BK virus infection 53.54 14.94 31 38184 2850 50564059
Tri-iodothyronine free increased 53.33 14.94 15 38200 196 50566713
Autoimmune thyroid disorder 53.12 14.94 9 38206 3 50566906
Chills 52.89 14.94 177 38038 96510 50470399
pH urine increased 52.33 14.94 17 38198 371 50566538
Meningitis listeria 52.30 14.94 18 38197 472 50566437
Eosinophil percentage increased 50.46 14.94 21 38194 937 50565972
Mean cell haemoglobin concentration increased 49.20 14.94 17 38198 451 50566458
Encephalitis viral 48.99 14.94 24 38191 1573 50565336
Specific gravity urine increased 48.89 14.94 14 38201 196 50566713
Arthralgia 48.88 14.94 169 38046 438533 50128376
Menstruation irregular 48.58 14.94 39 38176 6123 50560786
Acute graft versus host disease in intestine 48.40 14.94 24 38191 1615 50565294
Poor quality sleep 47.95 14.94 61 38154 16585 50550324
Thyroid stimulating immunoglobulin 47.93 14.94 11 38204 58 50566851
Thyroxine free decreased 47.20 14.94 17 38198 511 50566398
Haemophagocytic lymphohistiocytosis 46.55 14.94 44 38171 8589 50558320
Transplant rejection 46.23 14.94 46 38169 9563 50557346
Haemoglobin decreased 45.09 14.94 203 38012 127013 50439896
Thyroid function test abnormal 44.42 14.94 29 38186 3303 50563606
Crystalluria 44.29 14.94 15 38200 374 50566535
Therapeutic product effect incomplete 43.91 14.94 8 38207 91507 50475402
Band neutrophil percentage increased 43.79 14.94 13 38202 208 50566701
Herpes simplex 43.47 14.94 39 38176 7123 50559786
Anti-glomerular basement membrane disease 43.33 14.94 7 38208 0 50566909
Creatinine urine decreased 42.24 14.94 12 38203 163 50566746
Abdominal discomfort 41.89 14.94 69 38146 231572 50335337
Myelocyte count increased 41.73 14.94 14 38201 339 50566570
T-lymphocyte count decreased 41.18 14.94 13 38202 258 50566651
Insomnia 41.16 14.94 249 37966 174616 50392293
Atrial fibrillation 40.79 14.94 13 38202 101732 50465177
Eosinophil percentage decreased 40.71 14.94 12 38203 187 50566722
Monocyte percentage decreased 40.42 14.94 12 38203 192 50566717
Acute disseminated encephalomyelitis 40.31 14.94 12 38203 194 50566715
Injection site erythema 39.49 14.94 5 38210 74931 50491978
Neuropathy peripheral 39.44 14.94 12 38203 96745 50470164
Bacteriuria 39.07 14.94 16 38199 685 50566224
Arthritis 38.67 14.94 9 38206 86712 50480197
White blood cells urine 38.06 14.94 13 38202 333 50566576
Gastrointestinal disorder 37.99 14.94 12 38203 94444 50472465
Band neutrophil count increased 37.87 14.94 13 38202 338 50566571
Heart rate increased 37.53 14.94 136 38079 77114 50489795
Hypersensitivity 37.14 14.94 66 38149 215095 50351814
Chronic graft versus host disease in liver 36.76 14.94 12 38203 266 50566643
Peripheral swelling 36.61 14.94 62 38153 205874 50361035
Hepatic enzyme increased 36.59 14.94 30 38185 137350 50429559
Infusion site extravasation 36.56 14.94 35 38180 6941 50559968
Urinary tract infection bacterial 36.41 14.94 28 38187 4131 50562778
Myocardial infarction 36.36 14.94 11 38204 89016 50477893
Platelet count abnormal 36.04 14.94 24 38191 2825 50564084
Impaired healing 35.95 14.94 5 38210 69781 50497128
Myelocyte percentage increased 35.59 14.94 11 38204 203 50566706
Multiple sclerosis 35.46 14.94 59 38156 20434 50546475
Acute graft versus host disease 35.42 14.94 27 38188 3931 50562978
Oropharyngeal pain 35.31 14.94 134 38081 77667 50489242
Menstrual disorder 35.18 14.94 28 38187 4342 50562567
Osteoarthritis 35.15 14.94 5 38210 68601 50498308
Gingival bleeding 34.93 14.94 43 38172 11310 50555599
Urine oxalate increased 34.48 14.94 11 38204 226 50566683
Acute kidney injury 34.17 14.94 76 38139 227982 50338927
Pulmonary haemorrhage 32.94 14.94 32 38183 6460 50560449
Pulmonary alveolar haemorrhage 32.84 14.94 26 38189 4001 50562908
Cystitis haemorrhagic 32.57 14.94 25 38190 3677 50563232
Neutrophil count decreased 32.35 14.94 92 38123 45934 50520975
Serum amyloid A protein increased 32.18 14.94 9 38206 115 50566794
Confusional state 32.11 14.94 57 38158 185871 50381038
Multiple organ dysfunction syndrome 31.93 14.94 97 38118 50240 50516669
Neutropenia 31.87 14.94 206 38009 147759 50419150
Drug exposure before pregnancy 31.86 14.94 14 38201 715 50566194
Autoimmune neutropenia 31.77 14.94 8 38207 66 50566843
Proteinuria 31.73 14.94 50 38165 16547 50550362
Eosinophil count decreased 31.68 14.94 18 38197 1597 50565312
Urinary tract infection 31.44 14.94 282 37933 223738 50343171
Sinus bradycardia 31.36 14.94 44 38171 13139 50553770
Mean cell haemoglobin increased 31.26 14.94 20 38195 2200 50564709
Basophil percentage increased 31.15 14.94 8 38207 72 50566837
Stomatitis 31.10 14.94 19 38196 101325 50465584
Central nervous system lesion 30.92 14.94 37 38178 9452 50557457
Bilirubin urine present 30.86 14.94 8 38207 75 50566834
Feeling cold 30.85 14.94 54 38161 19477 50547432
Vaginal discharge 30.75 14.94 28 38187 5212 50561697
Polyomavirus viraemia 30.71 14.94 12 38203 454 50566455
Thyroid stimulating immunoglobulin increased 30.67 14.94 8 38207 77 50566832
Idiopathic pneumonia syndrome 30.59 14.94 11 38204 329 50566580
Oedema peripheral 30.49 14.94 45 38170 157916 50408993
Mean platelet volume increased 30.15 14.94 12 38203 477 50566432
Basophil count increased 30.08 14.94 14 38201 818 50566091
Gastroenteritis adenovirus 30.03 14.94 9 38206 149 50566760
Hypoaesthesia 29.79 14.94 181 38034 127076 50439833
Heart rate decreased 29.70 14.94 77 38138 36420 50530489
Hyponatraemia 29.54 14.94 18 38197 96121 50470788
Psoriasis 29.14 14.94 8 38207 68992 50497917
Throat irritation 29.06 14.94 68 38147 30171 50536738
Anaemia 28.90 14.94 96 38119 252360 50314549
Depressed level of consciousness 28.54 14.94 3 38212 51950 50514959
White blood cell count increased 28.31 14.94 83 38132 42157 50524752
Mean cell volume increased 28.21 14.94 21 38194 2951 50563958
B-lymphocyte count increased 28.20 14.94 8 38207 108 50566801
Irritable bowel syndrome 28.18 14.94 3 38212 51438 50515471
Granulocyte percentage 28.10 14.94 7 38208 55 50566854
Creatinine urine increased 27.68 14.94 9 38206 197 50566712
Mycobacterium kansasii infection 27.43 14.94 8 38207 120 50566789
Guillain-Barre syndrome 27.40 14.94 22 38193 3455 50563454
Hypoglycaemia 27.22 14.94 4 38211 53577 50513332
Chronic obstructive pulmonary disease 27.12 14.94 4 38211 53431 50513478
Listeria test positive 27.01 14.94 5 38210 6 50566903
Progressive multifocal leukoencephalopathy 26.90 14.94 38 38177 11419 50555490
Thrombotic thrombocytopenic purpura 26.81 14.94 22 38193 3563 50563346
Immature granulocyte count increased 26.43 14.94 10 38205 346 50566563
Injury 26.43 14.94 3 38212 48922 50517987
Vulvovaginal mycotic infection 26.19 14.94 24 38191 4505 50562404
Mean platelet volume decreased 26.16 14.94 16 38199 1626 50565283
Discomfort 26.07 14.94 26 38189 108354 50458555
Expanded disability status scale score increased 26.06 14.94 10 38205 360 50566549
Cytomegalovirus infection reactivation 25.89 14.94 19 38196 2612 50564297
Thrombocytopenia 25.82 14.94 175 38040 127498 50439411
Lipaemic index score 25.67 14.94 7 38208 81 50566828
Quadriparesis 25.51 14.94 16 38199 1700 50565209
Contusion 25.27 14.94 158 38057 112025 50454884
Pericarditis 25.21 14.94 14 38201 78675 50488234
Pathogen resistance 25.11 14.94 26 38189 5663 50561246
Haematuria 25.06 14.94 58 38157 25555 50541354
Injection site reaction 24.82 14.94 4 38211 50028 50516881
Goodpasture's syndrome 24.76 14.94 4 38211 0 50566909
Legionella infection 24.65 14.94 10 38205 418 50566491
Optic neuritis 24.33 14.94 28 38187 6862 50560047
Infertility 24.31 14.94 11 38204 602 50566307
Adverse drug reaction 24.09 14.94 6 38209 55216 50511693
Thrombotic microangiopathy 23.42 14.94 31 38184 8760 50558149
Infusion site discomfort 23.42 14.94 12 38203 866 50566043
Acute myeloid leukaemia recurrent 23.32 14.94 14 38201 1376 50565533
Cellulitis staphylococcal 23.21 14.94 11 38204 670 50566239
Chronic graft versus host disease in skin 23.16 14.94 11 38204 673 50566236
Nasal septum disorder 23.08 14.94 7 38208 121 50566788
Neutrophil percentage decreased 22.99 14.94 9 38206 342 50566567
Ureaplasma infection 22.80 14.94 10 38205 508 50566401
Infusion related reaction 22.62 14.94 60 38155 169497 50397412
Cerebrovascular accident 22.44 14.94 23 38192 94657 50472252
Glomerulonephritis membranous 22.35 14.94 10 38205 533 50566376
Temperature intolerance 22.30 14.94 28 38187 7511 50559398
Fusarium infection 22.23 14.94 10 38205 540 50566369
Immune reconstitution inflammatory syndrome 22.20 14.94 24 38191 5492 50561417
Laboratory test abnormal 22.10 14.94 52 38163 23156 50543753
Glomerulonephritis chronic 21.85 14.94 7 38208 146 50566763
Suicide attempt 21.84 14.94 6 38209 51726 50515183
Incorrect dose administered 21.63 14.94 5 38210 48409 50518500
Oral herpes 21.46 14.94 48 38167 20677 50546232
Cytokine storm 21.28 14.94 8 38207 272 50566637
Retinal depigmentation 21.22 14.94 8 38207 274 50566635
Haematocrit increased 21.13 14.94 15 38200 1959 50564950
Systemic mycosis 20.91 14.94 12 38203 1085 50565824
Hepatitis infectious mononucleosis 20.82 14.94 6 38209 86 50566823
Epstein-Barr virus associated lymphoproliferative disorder 20.82 14.94 14 38201 1675 50565234
Immature granulocyte percentage increased 20.72 14.94 4 38211 7 50566902
Adverse event 20.61 14.94 4 38211 43759 50523150
Haemolytic anaemia 20.61 14.94 30 38185 9262 50557647
Bronchopulmonary aspergillosis 20.58 14.94 27 38188 7565 50559344
Oesophageal candidiasis 20.58 14.94 22 38193 4972 50561937
Cardiac failure congestive 20.57 14.94 20 38195 84362 50482547
Limb discomfort 20.45 14.94 52 38163 24305 50542604
Gastroenteritis norovirus 20.39 14.94 14 38201 1733 50565176
Vitiligo 20.34 14.94 12 38203 1142 50565767
Dehydration 20.29 14.94 54 38161 152395 50414514
Micturition urgency 20.28 14.94 28 38187 8236 50558673
Platelet count increased 20.17 14.94 38 38177 14502 50552407
Chronic kidney disease 20.13 14.94 3 38212 39768 50527141
Pollakiuria 20.11 14.94 51 38164 23800 50543109
Autoimmune pancytopenia 20.10 14.94 6 38209 98 50566811
Sinusitis 20.09 14.94 64 38151 170494 50396415
Nitrite urine 20.05 14.94 4 38211 9 50566900
Decreased appetite 19.96 14.94 81 38134 200842 50366067
Infusion site scar 19.86 14.94 8 38207 328 50566581
Thyroiditis 19.86 14.94 14 38201 1808 50565101
Cytomegalovirus chorioretinitis 19.80 14.94 13 38202 1494 50565415
Anaphylactic reaction 19.80 14.94 8 38207 54047 50512862
Lymphocyte percentage increased 19.77 14.94 8 38207 332 50566577
Brain stem syndrome 19.75 14.94 8 38207 333 50566576
Cystitis viral 19.50 14.94 6 38209 109 50566800
Exophthalmos 19.46 14.94 12 38203 1238 50565671
Cellulitis 19.42 14.94 15 38200 70783 50496126
Graft loss 19.39 14.94 8 38207 349 50566560
Meningism 19.26 14.94 8 38207 355 50566554
Malignant neoplasm progression 19.24 14.94 14 38201 68110 50498799
Post herpetic neuralgia 19.16 14.94 14 38201 1912 50564997
Periportal oedema 18.98 14.94 4 38211 13 50566896
Haemoglobin increased 18.98 14.94 17 38198 3098 50563811
Injection site pruritus 18.40 14.94 4 38211 40407 50526502
Erythema 18.35 14.94 180 38035 146234 50420675
Bronchostenosis 18.21 14.94 8 38207 408 50566501
Poor venous access 18.20 14.94 30 38185 10310 50556599
Chronic graft versus host disease 18.17 14.94 16 38199 2851 50564058
JC polyomavirus test positive 18.17 14.94 11 38204 1098 50565811
Dysuria 18.14 14.94 55 38160 28449 50538460
Thyroiditis subacute 18.14 14.94 7 38208 256 50566653
Fumbling 18.09 14.94 6 38209 140 50566769
Lymphadenopathy 18.01 14.94 61 38154 33438 50533471
Cardiac arrest 17.99 14.94 22 38193 83629 50483280
Bone marrow transplant rejection 17.94 14.94 5 38210 63 50566846
Fibrin D dimer increased 17.92 14.94 19 38196 4253 50562656
Haemoptysis 17.85 14.94 51 38164 25522 50541387
Chromaturia 17.65 14.94 36 38179 14554 50552355
Urine odour abnormal 17.58 14.94 21 38194 5352 50561557
Pseudomonas infection 17.46 14.94 28 38187 9402 50557507
Lymphodepletion 17.44 14.94 4 38211 21 50566888
Chronic hepatitis C 17.44 14.94 6 38209 157 50566752
Actinomycotic sepsis 17.39 14.94 5 38210 71 50566838
White blood cell count abnormal 17.38 14.94 21 38194 5419 50561490
Granulocyte count increased 17.36 14.94 8 38207 457 50566452
Malignant melanoma 17.35 14.94 29 38186 10079 50556830
Injection site swelling 17.35 14.94 5 38210 41768 50525141
Interleukin-2 receptor increased 17.33 14.94 5 38210 72 50566837
Infusion site swelling 17.14 14.94 24 38191 7152 50559757
Thyroxine decreased 16.99 14.94 8 38207 480 50566429
Microcytosis 16.93 14.94 6 38209 172 50566737
Maternal exposure before pregnancy 16.90 14.94 21 38194 5576 50561333
Monocyte count abnormal 16.89 14.94 6 38209 173 50566736
Pneumonia cytomegaloviral 16.84 14.94 13 38202 1928 50564981
Musculoskeletal stiffness 16.73 14.94 46 38169 128435 50438474
Acute motor axonal neuropathy 16.72 14.94 4 38211 26 50566883
Diffuse large B-cell lymphoma 16.70 14.94 21 38194 5641 50561268
Lymphocyte percentage abnormal 16.59 14.94 4 38211 27 50566882
Chronic lymphocytic leukaemia recurrent 16.58 14.94 6 38209 183 50566726
Evans syndrome 16.51 14.94 6 38209 185 50566724
Natural killer cell count increased 16.49 14.94 3 38212 3 50566906
CD4 lymphocyte percentage decreased 16.49 14.94 3 38212 3 50566906
Fungal infection 16.49 14.94 55 38160 29910 50536999
Anti-thyroid antibody 16.46 14.94 4 38211 28 50566881
International normalised ratio increased 16.44 14.94 6 38209 43146 50523763
Fungal skin infection 16.27 14.94 17 38198 3742 50563167
Infusion site rash 16.25 14.94 11 38204 1331 50565578
Thyroid disorder 16.20 14.94 32 38183 12645 50554264
Basophil count decreased 15.99 14.94 5 38210 96 50566813
Palpitations 15.91 14.94 124 38091 94382 50472527
Growth retardation 15.90 14.94 10 38205 1068 50565841
Lactic acidosis 15.81 14.94 3 38212 33352 50533557
Thyroid cyst 15.77 14.94 8 38207 565 50566344
Folliculitis 15.73 14.94 5 38210 39220 50527689
Diverticulitis 15.70 14.94 3 38212 33179 50533730
Blood luteinising hormone decreased 15.68 14.94 4 38211 35 50566874
Disorder of globe 15.63 14.94 3 38212 5 50566904
Loss of personal independence in daily activities 15.51 14.94 18 38197 70032 50496877
Cytomegalovirus test positive 15.50 14.94 14 38201 2578 50564331
Tri-iodothyronine free abnormal 15.48 14.94 4 38211 37 50566872
Cough 15.46 14.94 262 37953 241002 50325907
Hallucination 15.38 14.94 8 38207 46649 50520260
Diabetes mellitus 15.31 14.94 9 38206 49024 50517885
Endometrial ablation 15.28 14.94 9 38206 854 50566055
Extensor plantar response 15.27 14.94 10 38205 1144 50565765
Pneumonitis 15.22 14.94 53 38162 29457 50537452
C-reactive protein increased 15.19 14.94 94 38121 66380 50500529
Hypokalaemia 15.15 14.94 27 38188 87965 50478944
Haemoglobin urine 15.14 14.94 5 38210 115 50566794
Aspiration bone marrow abnormal 15.11 14.94 4 38211 41 50566868
Thrombosis 15.10 14.94 12 38203 55821 50511088
Vomiting 15.10 14.94 251 37964 460507 50106402
Skin ulcer 15.09 14.94 4 38211 35314 50531595
Microsporidia infection 15.08 14.94 6 38209 238 50566671
Albumin urine present 14.99 14.94 6 38209 242 50566667

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 522.92 16.58 271 19372 22944 29531940
Immune thrombocytopenia 359.15 16.58 150 19493 7727 29547157
Autoimmune haemolytic anaemia 222.63 16.58 87 19556 3761 29551123
Lymphopenia 202.89 16.58 121 19522 13412 29541472
Adenovirus infection 193.66 16.58 82 19561 4365 29550519
Lymphocyte count decreased 161.66 16.58 120 19523 19151 29535733
Progressive multifocal leukoencephalopathy 160.14 16.58 89 19554 8630 29546254
Post transplant lymphoproliferative disorder 158.55 16.58 76 19567 5417 29549467
Graft versus host disease 154.56 16.58 90 19553 9538 29545346
Microsporidia infection 138.02 16.58 38 19605 525 29554359
End stage renal disease 137.39 16.58 77 19566 7587 29547297
Lymphocyte percentage decreased 136.01 16.58 51 19592 1966 29552918
Multiple sclerosis relapse 135.46 16.58 88 19555 11331 29543553
Pyrexia 129.19 16.58 451 19192 287171 29267713
JC virus infection 128.04 16.58 48 19595 1849 29553035
Epstein-Barr virus infection 125.39 16.58 69 19574 6560 29548324
Transplant failure 112.28 16.58 49 19594 2807 29552077
Graft versus host disease in gastrointestinal tract 106.10 16.58 49 19594 3209 29551675
Acute graft versus host disease in skin 100.66 16.58 53 19590 4611 29550273
Neutrophil percentage increased 98.55 16.58 39 19604 1742 29553142
Crystal urine present 96.19 16.58 27 19616 402 29554482
Transplant rejection 94.81 16.58 65 19578 9147 29545737
Herpes simplex 92.75 16.58 51 19592 4839 29550045
Off label use 92.35 16.58 419 19224 300381 29254503
Monocyte percentage increased 91.59 16.58 31 19612 882 29554002
Chronic graft versus host disease in skin 78.86 16.58 27 19616 796 29554088
BK virus infection 78.18 16.58 45 19598 4662 29550222
Cytomegalovirus viraemia 75.66 16.58 49 19594 6271 29548613
Urine abnormality 72.95 16.58 31 19612 1663 29553221
Graft versus host disease in skin 71.79 16.58 38 19605 3341 29551543
Meningitis viral 71.43 16.58 25 19618 788 29554096
Human herpesvirus 6 infection 70.11 16.58 31 19612 1832 29553052
Epstein-Barr viraemia 66.92 16.58 25 19618 953 29553931
Acute graft versus host disease in intestine 66.36 16.58 32 19611 2309 29552575
Cytomegalovirus infection reactivation 66.33 16.58 36 19607 3328 29551556
Drug interaction 64.96 16.58 25 19618 197360 29357524
Herpes zoster 64.13 16.58 89 19554 29963 29524921
Pneumonia cytomegaloviral 62.23 16.58 32 19611 2650 29552234
Product use in unapproved indication 62.18 16.58 161 19482 86714 29468170
Blood thyroid stimulating hormone decreased 61.55 16.58 28 19615 1770 29553114
Haemolytic anaemia 60.23 16.58 50 19593 9369 29545515
Toxoplasmosis 59.18 16.58 24 19619 1143 29553741
Multiple organ dysfunction syndrome 56.99 16.58 128 19515 62988 29491896
Epstein-Barr virus associated lymphoproliferative disorder 56.15 16.58 26 19617 1712 29553172
Magnetic resonance imaging abnormal 56.09 16.58 25 19618 1506 29553378
Thrombotic microangiopathy 55.34 16.58 46 19597 8635 29546249
Blood thyroid stimulating hormone increased 55.10 16.58 31 19612 3074 29551810
Acute graft versus host disease 55.02 16.58 39 19604 5785 29549099
Urine analysis abnormal 55.00 16.58 26 19617 1794 29553090
Endocrine ophthalmopathy 53.32 16.58 11 19632 37 29554847
Venoocclusive disease 52.37 16.58 28 19615 2511 29552373
Mucosal inflammation 52.21 16.58 83 19560 31512 29523372
Propionibacterium infection 52.20 16.58 15 19628 244 29554640
Graft loss 51.97 16.58 20 19623 828 29554056
Chronic graft versus host disease 50.10 16.58 32 19611 3997 29550887
Autoimmune thyroiditis 48.09 16.58 20 19623 1016 29553868
Red blood cells urine positive 47.82 16.58 23 19620 1650 29553234
Haemophagocytic lymphohistiocytosis 47.78 16.58 46 19597 10458 29544426
Central nervous system lymphoma 47.45 16.58 18 19625 716 29554168
White blood cells urine positive 45.68 16.58 20 19623 1154 29553730
Urine leukocyte esterase positive 45.59 16.58 15 19628 390 29554494
Leukaemia recurrent 44.33 16.58 21 19622 1456 29553428
Bacterial test positive 43.92 16.58 26 19617 2837 29552047
Pancytopenia 43.77 16.58 138 19505 83030 29471854
Diffuse large B-cell lymphoma 43.67 16.58 35 19608 6241 29548643
Adenovirus reactivation 43.28 16.58 11 19632 109 29554775
Completed suicide 42.60 16.58 5 19638 90241 29464643
Toxicity to various agents 42.49 16.58 32 19611 173629 29381255
Polyomavirus viraemia 42.26 16.58 16 19627 633 29554251
Nitrite urine present 41.84 16.58 11 19632 126 29554758
Chronic graft versus host disease in intestine 41.43 16.58 12 19631 201 29554683
Urine ketone body present 41.25 16.58 18 19625 1030 29553854
Specific gravity urine increased 41.07 16.58 11 19632 136 29554748
Pulmonary nocardiosis 40.65 16.58 15 19628 552 29554332
Polymyositis 40.22 16.58 19 19624 1309 29553575
CD4 lymphocytes decreased 39.79 16.58 20 19623 1578 29553306
Chronic graft versus host disease in liver 39.73 16.58 13 19630 332 29554552
Meningitis tuberculous 39.23 16.58 15 19628 610 29554274
Red cell distribution width increased 38.74 16.58 29 19614 4678 29550206
Varicella 38.47 16.58 19 19624 1444 29553440
Haematocrit decreased 38.33 16.58 69 19574 28953 29525931
Cystitis viral 38.29 16.58 14 19629 502 29554382
Chronic lymphocytic leukaemia transformation 38.28 16.58 11 19632 179 29554705
Atypical mycobacterial pneumonia 36.39 16.58 10 19633 137 29554747
Parainfluenzae virus infection 36.01 16.58 21 19622 2228 29552656
Lymphocyte count abnormal 35.63 16.58 14 19629 613 29554271
Enterococcal infection 35.34 16.58 35 19608 8233 29546651
Venoocclusive liver disease 34.72 16.58 32 19611 6885 29547999
Mean cell haemoglobin concentration decreased 34.61 16.58 16 19627 1049 29553835
Human polyomavirus infection 34.31 16.58 14 19629 677 29554207
Death 34.22 16.58 115 19528 341969 29212915
Anti-thyroid antibody positive 34.07 16.58 8 19635 55 29554829
Epstein-Barr virus infection reactivation 33.76 16.58 13 19630 539 29554345
Chills 33.62 16.58 114 19529 71186 29483698
Acanthamoeba infection 33.48 16.58 12 19631 406 29554478
Bronchopulmonary aspergillosis 33.22 16.58 41 19602 12303 29542581
Aspergillus infection 33.19 16.58 38 19605 10543 29544341
Platelet count decreased 32.75 16.58 147 19496 104525 29450359
Pseudomonas infection 32.40 16.58 38 19605 10814 29544070
Hyperthyroidism 32.36 16.58 34 19609 8574 29546310
Arthralgia 31.31 16.58 28 19615 139589 29415295
Dyspnoea 31.21 16.58 112 19531 326620 29228264
Eosinophil percentage increased 31.11 16.58 12 19631 500 29554384
Listeria sepsis 30.89 16.58 9 19634 154 29554730
Dizziness 30.86 16.58 49 19594 189635 29365249
Stenotrophomonas infection 30.08 16.58 17 19626 1700 29553184
Myocardial infarction 30.07 16.58 18 19625 110278 29444606
Bacteriuria 29.79 16.58 10 19633 277 29554607
Varicella zoster virus infection 29.75 16.58 16 19627 1452 29553432
Neutropenia 29.27 16.58 168 19475 131543 29423341
Diarrhoea 29.22 16.58 118 19525 332580 29222304
Meningeal neoplasm 28.45 16.58 7 19636 60 29554824
Viraemia 28.39 16.58 14 19629 1060 29553824
White blood cell count decreased 28.29 16.58 120 19523 83242 29471642
Normocytic anaemia 27.74 16.58 17 19626 1975 29552909
Klebsiella sepsis 27.69 16.58 16 19627 1668 29553216
Fall 27.67 16.58 47 19596 177131 29377753
Apoptosis 27.54 16.58 9 19634 229 29554655
Myositis 27.42 16.58 34 19609 10249 29544635
Listeriosis 27.39 16.58 13 19630 905 29553979
Petechiae 27.25 16.58 31 19612 8540 29546344
pH urine increased 27.13 16.58 7 19636 74 29554810
Nocardiosis 26.64 16.58 20 19623 3240 29551644
Anogenital warts 26.54 16.58 11 19632 554 29554330
Bacterial test 26.48 16.58 8 19635 156 29554728
Autoimmune disorder 26.47 16.58 15 19628 1508 29553376
Leukopenia 25.78 16.58 88 19555 55115 29499769
Cytomegalovirus test positive 25.77 16.58 20 19623 3403 29551481
Thrombocytopenia 25.54 16.58 165 19478 134658 29420226
Diarrhoea haemorrhagic 25.35 16.58 25 19618 5849 29549035
Stem cell transplant 25.25 16.58 16 19627 1971 29552913
Encephalitis 25.25 16.58 26 19617 6404 29548480
Band neutrophil percentage increased 24.95 16.58 7 19636 104 29554780
Graft versus host disease in lung 24.36 16.58 10 19633 491 29554393
Neutrophil percentage decreased 24.07 16.58 9 19634 344 29554540
Albuminuria 23.75 16.58 9 19634 357 29554527
Factor VIII deficiency 23.59 16.58 7 19636 128 29554756
Mycobacterium kansasii infection 23.29 16.58 8 19635 238 29554646
Meningitis listeria 23.22 16.58 9 19634 380 29554504
Epstein-Barr virus associated lymphoma 22.95 16.58 10 19633 570 29554314
Phaeohyphomycosis 22.87 16.58 11 19632 789 29554095
Bilirubin urine present 22.60 16.58 7 19636 149 29554735
Syncope 22.57 16.58 13 19630 81358 29473526
Herpes zoster meningoencephalitis 22.54 16.58 8 19635 263 29554621
Activated partial thromboplastin time shortened 22.32 16.58 9 19634 422 29554462
Haematocrit increased 22.32 16.58 14 19629 1694 29553190
Skin papilloma 22.02 16.58 14 19629 1735 29553149
Retinitis 22.01 16.58 8 19635 282 29554602
Drug hypersensitivity 21.90 16.58 9 19634 68397 29486487
Chronic lymphocytic leukaemia refractory 21.78 16.58 6 19637 83 29554801
Confusional state 21.77 16.58 32 19611 127845 29427039
Intracranial tumour haemorrhage 21.61 16.58 8 19635 297 29554587
Autoimmune pancytopenia 21.58 16.58 6 19637 86 29554798
Specific gravity urine decreased 21.33 16.58 6 19637 90 29554794
Leukaemic infiltration 21.27 16.58 6 19637 91 29554793
Band sensation 21.27 16.58 6 19637 91 29554793
Urinary sediment present 21.20 16.58 7 19636 184 29554700
Transplant dysfunction 20.97 16.58 15 19628 2255 29552629
Blood urine present 20.96 16.58 29 19614 9726 29545158
Oral herpes 20.89 16.58 20 19623 4512 29550372
Glucose urine present 20.83 16.58 11 19632 962 29553922
Bone marrow transplant rejection 20.82 16.58 7 19636 195 29554689
Necrotising oesophagitis 20.66 16.58 9 19634 513 29554371
Lymphadenopathy 20.59 16.58 49 19594 25000 29529884
Gastrointestinal haemorrhage 20.27 16.58 14 19629 79519 29475365
Systemic mycosis 20.27 16.58 12 19631 1309 29553575
Bacterial sepsis 20.27 16.58 20 19623 4683 29550201
Acute graft versus host disease in liver 20.13 16.58 12 19631 1326 29553558
Monocyte count abnormal 19.82 16.58 5 19638 48 29554836
Thyroxine free increased 19.78 16.58 7 19636 228 29554656
Posterior reversible encephalopathy syndrome 19.76 16.58 27 19616 8949 29545935
Tuberculosis liver 19.72 16.58 5 19638 49 29554835
Muscle spasticity 19.63 16.58 20 19623 4863 29550021
Band neutrophil count increased 19.50 16.58 7 19636 238 29554646
Acute myeloid leukaemia recurrent 19.35 16.58 13 19630 1767 29553117
Granulocyte percentage 18.95 16.58 3 19640 0 29554884
Thyroid stimulating immunoglobulin 18.95 16.58 3 19640 0 29554884
Chronic lymphocytic leukaemia 18.61 16.58 17 19626 3616 29551268
Protein urine present 18.46 16.58 19 19624 4675 29550209
Fungal skin infection 18.03 16.58 14 19629 2384 29552500
Platelet morphology abnormal 17.80 16.58 4 19639 22 29554862
Cerebrovascular accident 17.74 16.58 15 19628 76896 29477988
Haemorrhagic cyst 17.71 16.58 5 19638 76 29554808
Polyomavirus-associated nephropathy 17.61 16.58 16 19627 3380 29551504
International normalised ratio increased 17.50 16.58 4 19639 44368 29510516
B-lymphocyte count decreased 17.40 16.58 8 19635 518 29554366
Coronary artery disease 17.40 16.58 4 19639 44186 29510698
Constipation 17.15 16.58 31 19612 114129 29440755
Gastroenteritis norovirus 17.14 16.58 11 19632 1385 29553499
Red blood cell elliptocytes present 16.93 16.58 5 19638 90 29554794
Monocyte count decreased 16.91 16.58 10 19633 1088 29553796
Immature granulocyte percentage increased 16.88 16.58 3 19640 3 29554881
Red blood cell count decreased 16.80 16.58 46 19597 25556 29529328

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lymphocyte count decreased 958.85 13.29 531 53987 40168 64404046
Immune thrombocytopenia 846.85 13.29 357 54161 14709 64429505
Cytomegalovirus infection 777.87 13.29 449 54069 36750 64407464
Urine abnormality 735.99 13.29 265 54253 7097 64437117
Multiple sclerosis relapse 496.22 13.29 351 54167 40784 64403430
White blood cells urine positive 471.69 13.29 176 54342 5222 64438992
Lymphocyte percentage decreased 470.85 13.29 169 54349 4480 64439734
Urine leukocyte esterase positive 466.06 13.29 155 54363 3248 64440966
Lymphopenia 453.45 13.29 278 54240 25379 64418835
Urinary sediment present 443.45 13.29 135 54383 2099 64442115
Red blood cells urine positive 428.13 13.29 156 54362 4322 64439892
Adenovirus infection 427.94 13.29 178 54340 7077 64437137
Crystal urine present 414.86 13.29 124 54394 1805 64442409
Neutrophil percentage increased 403.31 13.29 149 54369 4296 64439918
Urine analysis abnormal 372.77 13.29 151 54367 5605 64438609
Blood urine present 350.53 13.29 209 54309 18131 64426083
Autoimmune haemolytic anaemia 282.56 13.29 132 54386 6944 64437270
Blood thyroid stimulating hormone decreased 274.10 13.29 118 54400 5112 64439102
Bacterial test positive 270.86 13.29 126 54392 6564 64437650
Graft versus host disease 268.09 13.29 159 54359 13654 64430560
Urine ketone body present 267.78 13.29 102 54416 3205 64441009
Bacterial test 261.34 13.29 78 54440 1129 64443085
Post transplant lymphoproliferative disorder 256.40 13.29 136 54382 9408 64434806
Red cell distribution width increased 242.32 13.29 143 54375 12166 64432048
Autoimmune thyroiditis 240.35 13.29 96 54422 3432 64440782
Nitrite urine present 230.91 13.29 69 54449 1003 64443211
Monocyte percentage increased 230.31 13.29 80 54438 1920 64442294
Graft versus host disease in skin 223.62 13.29 103 54415 5244 64438970
Acute graft versus host disease in skin 219.69 13.29 110 54408 6745 64437469
Blood thyroid stimulating hormone increased 199.77 13.29 107 54411 7547 64436667
Pyrexia 191.27 13.29 954 53564 557690 63886524
Drug interaction 189.44 13.29 38 54480 362045 64082169
Flushing 179.51 13.29 273 54245 78375 64365839
Headache 177.50 13.29 899 53619 528568 63915646
Haemoglobin urine present 174.90 13.29 53 54465 810 64443404
Completed suicide 170.57 13.29 4 54514 224410 64219804
Hyperthyroidism 169.53 13.29 133 54385 18046 64426168
Transplant failure 164.67 13.29 75 54443 3719 64440495
Magnetic resonance imaging abnormal 158.86 13.29 69 54449 3054 64441160
Herpes simplex 155.69 13.29 102 54416 10434 64433780
Haematocrit decreased 154.42 13.29 210 54308 54445 64389769
Epstein-Barr virus infection 153.79 13.29 108 54410 12380 64431834
Product dose omission issue 149.84 13.29 3 54515 194744 64249470
Culture urine positive 149.10 13.29 72 54446 4079 64440135
White blood cell count decreased 144.43 13.29 373 54145 157464 64286750
Protein urine present 142.92 13.29 91 54427 8865 64435349
Specific gravity urine decreased 141.34 13.29 44 54474 739 64443475
Microsporidia infection 141.23 13.29 44 54474 741 64443473
Leukocyturia 141.15 13.29 52 54466 1486 64442728
Thyroxine free increased 134.13 13.29 46 54472 1061 64443153
Transplant rejection 130.17 13.29 112 54406 17289 64426925
Toxicity to various agents 129.85 13.29 73 54445 363440 64080774
Progressive multifocal leukoencephalopathy 129.63 13.29 114 54404 18118 64426096
Mean cell haemoglobin decreased 125.80 13.29 64 54454 4058 64440156
Drug hypersensitivity 124.19 13.29 25 54493 237790 64206424
Cytomegalovirus viraemia 122.65 13.29 89 54429 10739 64433475
Graft versus host disease in gastrointestinal tract 117.85 13.29 68 54450 5544 64438670
Rheumatoid arthritis 117.42 13.29 5 54513 164289 64279925
Overdose 116.96 13.29 4 54514 159562 64284652
Anti-thyroid antibody positive 116.84 13.29 34 54484 448 64443766
Monocyte count decreased 116.24 13.29 54 54464 2803 64441411
JC virus infection 113.91 13.29 56 54462 3299 64440915
Human herpesvirus 6 infection 112.93 13.29 62 54456 4592 64439622
Endocrine ophthalmopathy 112.48 13.29 32 54486 387 64443827
End stage renal disease 111.66 13.29 83 54435 10392 64433822
Platelet count decreased 108.49 13.29 350 54168 167361 64276853
CD4 lymphocytes decreased 108.41 13.29 49 54469 2386 64441828
Chest discomfort 107.82 13.29 276 54242 115830 64328384
Specific gravity urine increased 101.69 13.29 30 54488 416 64443798
Death 100.69 13.29 158 54360 482547 63961667
Drug ineffective 98.07 13.29 373 54145 839874 63604340
Drug intolerance 95.58 13.29 21 54497 187971 64256243
Neutrophil count increased 95.36 13.29 112 54406 25062 64419152
Urinary casts 93.49 13.29 35 54483 1047 64443167
Lymphocyte count abnormal 92.87 13.29 33 54485 848 64443366
Autoimmune disorder 92.56 13.29 59 54459 5757 64438457
Monocyte count increased 90.58 13.29 66 54452 8013 64436201
Infusion site pain 90.37 13.29 73 54445 10324 64433890
Fall 89.23 13.29 134 54384 416692 64027522
Chronic graft versus host disease in skin 88.37 13.29 36 54482 1355 64442859
Feeling hot 86.95 13.29 146 54372 45517 64398697
Diarrhoea 86.72 13.29 317 54201 722387 63721827
Epstein-Barr viraemia 85.88 13.29 38 54480 1759 64442455
Acute graft versus host disease 85.85 13.29 67 54451 9017 64435197
Varicella zoster virus infection 84.01 13.29 48 54470 3840 64440374
Herpes zoster 83.84 13.29 198 54320 78989 64365225
Mean cell haemoglobin concentration decreased 83.70 13.29 47 54471 3637 64440577
Drug monitoring procedure not performed 83.66 13.29 30 54488 792 64443422
Joint swelling 83.15 13.29 39 54479 215343 64228871
Red cell distribution width decreased 82.37 13.29 32 54486 1061 64443153
BK virus infection 81.85 13.29 60 54458 7352 64436862
Cytomegalovirus infection reactivation 80.86 13.29 54 54464 5702 64438512
Epstein-Barr virus infection reactivation 80.36 13.29 32 54486 1134 64443080
Acute graft versus host disease in intestine 79.18 13.29 45 54473 3564 64440650
Mean cell volume decreased 77.68 13.29 44 54474 3462 64440752
Eosinophil percentage increased 77.48 13.29 33 54485 1391 64442823
pH urine increased 76.71 13.29 24 54494 410 64443804
Chronic graft versus host disease 76.63 13.29 54 54464 6222 64437992
Arthropathy 76.56 13.29 7 54511 120960 64323254
Bradycardia 75.75 13.29 246 54272 117973 64326241
Myocardial infarction 75.72 13.29 23 54495 165798 64278416
Red blood cells urine 74.57 13.29 26 54492 631 64443583
Red blood cell count decreased 73.27 13.29 140 54378 48246 64395968
Eosinophil count increased 73.03 13.29 74 54444 14038 64430176
Mucoepidermoid carcinoma of salivary gland 72.59 13.29 17 54501 87 64444127
Red blood cell count increased 71.79 13.29 42 54476 3513 64440701
Leukopenia 71.59 13.29 218 54300 101024 64343190
Synovitis 70.83 13.29 3 54515 99087 64345127
Band sensation 70.30 13.29 25 54493 644 64443570
Chronic graft versus host disease in liver 70.25 13.29 24 54494 547 64443667
Tachycardia 69.27 13.29 280 54238 149299 64294915
Body temperature increased 68.16 13.29 116 54402 36550 64407664
Urobilinogen urine increased 67.86 13.29 24 54494 608 64443606
Graft loss 67.20 13.29 27 54491 980 64443234
CD4 lymphocytes abnormal 66.47 13.29 14 54504 39 64444175
Muscular weakness 65.98 13.29 247 54271 127091 64317123
Petechiae 65.83 13.29 80 54438 18546 64425668
Bilirubin urine present 65.73 13.29 20 54498 310 64443904
Heavy menstrual bleeding 65.56 13.29 65 54453 12012 64432202
Bacteriuria 65.44 13.29 26 54492 916 64443298
Chills 65.20 13.29 259 54259 137005 64307209
Pneumonia cytomegaloviral 64.08 13.29 42 54476 4297 64439917
Thyroid stimulating immunoglobulin 62.01 13.29 14 54504 59 64444155
Band neutrophil percentage increased 61.85 13.29 20 54498 382 64443832
Confusional state 61.78 13.29 78 54440 261066 64183148
Viraemia 61.75 13.29 33 54485 2316 64441898
Rhabdomyolysis 61.72 13.29 4 54514 91722 64352492
Acute kidney injury 61.32 13.29 186 54332 449054 63995160
Listeriosis 61.32 13.29 31 54487 1939 64442275
Autoimmune neutropenia 61.08 13.29 20 54498 398 64443816
Pain 60.99 13.29 251 54267 553260 63890954
Urticaria 60.61 13.29 266 54252 147051 64297163
Polyomavirus viraemia 60.17 13.29 26 54492 1136 64443078
Atrial fibrillation 60.07 13.29 35 54483 171054 64273160
Arthralgia 59.73 13.29 184 54334 442076 64002138
Injection site pain 59.61 13.29 11 54507 111397 64332817
Hypothyroidism 58.73 13.29 115 54403 40342 64403872
Multiple organ dysfunction syndrome 57.86 13.29 203 54315 101210 64343004
Hypoglycaemia 57.42 13.29 5 54513 89887 64354327
Cells in urine 57.05 13.29 16 54502 183 64444031
Blood thyroid stimulating hormone abnormal 56.78 13.29 22 54496 724 64443490
Menstruation irregular 56.10 13.29 39 54479 4396 64439818
Meningitis listeria 55.89 13.29 22 54496 756 64443458
Urine leukocyte esterase 55.31 13.29 15 54503 150 64444064
Haemolytic anaemia 55.19 13.29 68 54450 15985 64428229
Poor quality sleep 53.77 13.29 73 54445 18878 64425336
Thrombotic microangiopathy 53.20 13.29 68 54450 16587 64427627
Diffuse large B-cell lymphoma 53.01 13.29 54 54464 10307 64433907
Tri-iodothyronine free decreased 51.65 13.29 17 54501 344 64443870
Oedema peripheral 51.65 13.29 61 54457 210256 64233958
Anaemia 50.78 13.29 158 54360 378522 64065692
Meningitis viral 50.19 13.29 26 54492 1712 64442502
Blood creatinine decreased 49.94 13.29 44 54474 7006 64437208
Hyponatraemia 49.76 13.29 32 54486 148307 64295907
Tri-iodothyronine free increased 49.69 13.29 15 54503 226 64443988
Cystitis viral 49.22 13.29 19 54499 619 64443595
Mean cell haemoglobin concentration increased 48.74 13.29 20 54498 767 64443447
Band neutrophil count increased 48.74 13.29 19 54499 636 64443578
Epstein-Barr virus associated lymphoproliferative disorder 48.05 13.29 31 54487 3088 64441126
Thyroxine free decreased 47.41 13.29 20 54498 823 64443391
Oropharyngeal pain 47.37 13.29 174 54344 88693 64355521
Mycobacterium kansasii infection 47.01 13.29 15 54503 274 64443940
Urinary tract infection bacterial 46.73 13.29 37 54481 5084 64439130
Swelling 46.73 13.29 40 54478 160178 64284036
Propionibacterium infection 45.79 13.29 15 54503 299 64443915
Venoocclusive disease 45.69 13.29 33 54485 3952 64440262
Central nervous system lesion 45.34 13.29 53 54465 11796 64432418
Thyroid function test abnormal 45.30 13.29 29 54489 2850 64441364
Adenovirus reactivation 44.70 13.29 14 54504 240 64443974
Autoimmune hypothyroidism 44.69 13.29 13 54505 171 64444043
Monocyte percentage decreased 44.60 13.29 14 54504 242 64443972
Toxoplasmosis 44.47 13.29 27 54491 2417 64441797
Maternal exposure during pregnancy 44.30 13.29 13 54505 95871 64348343
Neuropathy peripheral 44.23 13.29 22 54496 117503 64326711
International normalised ratio increased 44.15 13.29 7 54511 79160 64365054
Gastroenteritis adenovirus 43.91 13.29 14 54504 255 64443959
Eosinophil percentage decreased 43.86 13.29 14 54504 256 64443958
Product use in unapproved indication 43.66 13.29 277 54241 176341 64267873
Multiple sclerosis 43.52 13.29 66 54452 18875 64425339
Insomnia 43.31 13.29 301 54217 197535 64246679
Infusion site extravasation 43.18 13.29 40 54478 6797 64437417
Systemic mycosis 43.14 13.29 26 54492 2297 64441917
T-lymphocyte count decreased 42.98 13.29 16 54502 471 64443743
Chronic graft versus host disease in intestine 42.55 13.29 14 54504 283 64443931
Mean cell haemoglobin increased 42.49 13.29 29 54489 3173 64441041
Acute disseminated encephalomyelitis 42.41 13.29 14 54504 286 64443928
Central nervous system lymphoma 42.11 13.29 24 54494 1911 64442303
Mean platelet volume decreased 41.83 13.29 23 54495 1708 64442506
Cerebrovascular accident 41.79 13.29 33 54485 137550 64306664
Haematocrit increased 41.34 13.29 29 54489 3316 64440898
Arthritis 41.30 13.29 10 54508 83804 64360410
Acute myeloid leukaemia recurrent 41.24 13.29 27 54491 2757 64441457
Autoimmune thyroid disorder 40.91 13.29 8 54510 13 64444201
Platelet count abnormal 40.32 13.29 31 54487 4081 64440133
Glossodynia 40.25 13.29 4 54514 64692 64379522
Granulocyte percentage 40.16 13.29 10 54508 69 64444145
Wound 39.96 13.29 8 54510 76469 64367745
Neutrophil percentage decreased 39.86 13.29 17 54501 719 64443495
Cystitis haemorrhagic 39.85 13.29 41 54477 7915 64436299
Mucosal inflammation 39.84 13.29 130 54388 62454 64381760
Myelocyte count increased 39.51 13.29 17 54501 735 64443479
White blood cells urine 39.24 13.29 14 54504 364 64443850
Bronchopulmonary aspergillosis 38.98 13.29 63 54455 19022 64425192
Menstrual disorder 38.88 13.29 28 54490 3337 64440877
Lipaemic index score 38.82 13.29 11 54507 131 64444083
Cardiac failure 38.65 13.29 33 54485 132340 64311874
Haemophagocytic lymphohistiocytosis 38.55 13.29 60 54458 17549 64426665
Chronic obstructive pulmonary disease 38.03 13.29 7 54511 71041 64373173
Suicide attempt 38.00 13.29 7 54511 71000 64373214
Hyperkalaemia 37.95 13.29 19 54499 101110 64343104
Creatinine urine decreased 37.88 13.29 12 54506 214 64444000
Depressed level of consciousness 37.69 13.29 11 54507 81425 64362789
Urine oxalate increased 37.67 13.29 12 54506 218 64443996
Human polyomavirus infection 37.58 13.29 18 54500 1001 64443213
Peripheral swelling 37.57 13.29 75 54443 209078 64235136
Gastrointestinal haemorrhage 37.41 13.29 34 54484 132278 64311936
Acute myocardial infarction 37.04 13.29 7 54511 69711 64374503
Coronary artery disease 36.91 13.29 4 54514 60429 64383785
Myelocyte percentage increased 36.64 13.29 12 54506 239 64443975
Therapeutic product effect incomplete 36.55 13.29 21 54497 103461 64340753
Anti-glomerular basement membrane disease 36.46 13.29 6 54512 0 64444214
Lymphoproliferative disorder 36.45 13.29 32 54486 5071 64439143
Parainfluenzae virus infection 36.42 13.29 31 54487 4712 64439502
Syncope 36.30 13.29 48 54470 157587 64286627
Dehydration 36.20 13.29 81 54437 216682 64227532
Pulmonary nocardiosis 36.11 13.29 16 54502 743 64443471
Lactic acidosis 35.23 13.29 5 54513 61405 64382809
Decreased appetite 35.15 13.29 121 54397 281168 64163046
Pathogen resistance 35.10 13.29 48 54470 12495 64431719
Normocytic anaemia 34.84 13.29 26 54492 3273 64440941
Basophil percentage increased 34.77 13.29 10 54508 126 64444088
Drug reaction with eosinophilia and systemic symptoms 34.67 13.29 3 54515 54214 64390000
Crystalluria 34.59 13.29 16 54502 822 64443392
Psoriasis 34.47 13.29 9 54509 71694 64372520
Osteoarthritis 34.42 13.29 6 54512 63330 64380884
Cardiac arrest 34.38 13.29 48 54470 154016 64290198
Hypoaesthesia 34.26 13.29 218 54300 138890 64305324
Gastroenteritis norovirus 34.16 13.29 24 54494 2751 64441463
Optic neuritis 33.92 13.29 38 54480 8078 64436136
Pseudomonas infection 33.79 13.29 57 54461 17826 64426388
Chronic lymphocytic leukaemia transformation 33.45 13.29 11 54507 222 64443992
Cardio-respiratory arrest 33.30 13.29 21 54497 98372 64345842
Urinary tract infection 33.16 13.29 320 54198 231276 64212938
Gingival bleeding 33.05 13.29 51 54467 14803 64429411
Monocyte count abnormal 32.81 13.29 10 54508 156 64444058
Rotavirus infection 32.67 13.29 14 54504 599 64443615
Vaginal discharge 32.50 13.29 27 54491 3970 64440244
Listeria sepsis 32.50 13.29 14 54504 607 64443607
B-lymphocyte count decreased 32.47 13.29 17 54501 1144 64443070
Immature granulocyte count increased 32.32 13.29 13 54505 473 64443741
Mean platelet volume increased 32.24 13.29 16 54502 962 64443252
Glucose urine present 32.22 13.29 19 54499 1613 64442601
Oral herpes 32.18 13.29 63 54455 22089 64422125
Aspergillus infection 32.01 13.29 53 54465 16326 64427888
Injection site erythema 31.98 13.29 10 54508 70790 64373424
Anogenital warts 31.96 13.29 15 54503 797 64443417
CD4 lymphocyte percentage decreased 31.83 13.29 6 54512 7 64444207
Bone marrow transplant rejection 31.82 13.29 11 54507 260 64443954
Rash 31.74 13.29 554 53964 457995 63986219
Haemoglobin decreased 31.70 13.29 277 54241 194786 64249428
Neutrophil count decreased 31.42 13.29 139 54379 77057 64367157
Enterococcal infection 31.41 13.29 48 54470 13818 64430396
Product use issue 31.20 13.29 50 54468 151665 64292549
Injury 31.11 13.29 5 54513 55987 64388227
Cardiac disorder 30.97 13.29 5 54513 55811 64388403
Listeria test positive 30.97 13.29 6 54512 9 64444205
Neutropenia 30.89 13.29 324 54194 239300 64204914
Autoimmune pancytopenia 30.87 13.29 10 54508 192 64444022
Mean cell volume increased 30.86 13.29 29 54489 5017 64439197
Idiopathic pneumonia syndrome 30.79 13.29 13 54505 536 64443678
Lymphadenopathy 30.64 13.29 98 54420 46588 64397626
Thyroiditis 30.55 13.29 25 54493 3599 64440615
Incorrect dose administered 30.43 13.29 7 54511 60758 64383456
Cytomegalovirus test positive 30.38 13.29 29 54489 5115 64439099
Hypokalaemia 30.29 13.29 35 54483 121868 64322346
Fusarium infection 30.27 13.29 18 54500 1551 64442663
Impaired healing 30.22 13.29 7 54511 60466 64383748
Alopecia 30.11 13.29 59 54459 165631 64278583
Hypersensitivity 29.95 13.29 77 54441 196375 64247839
Factor VIII deficiency 29.79 13.29 9 54509 136 64444078
Urine bilirubin decreased 29.73 13.29 9 54509 137 64444077
Hepatic enzyme increased 29.48 13.29 40 54478 129903 64314311
Pneumonia 29.36 13.29 317 54201 559259 63884955
Expanded disability status scale score increased 29.20 13.29 12 54506 462 64443752
Red blood cell elliptocytes present 29.14 13.29 9 54509 147 64444067
Acute graft versus host disease in liver 29.07 13.29 18 54500 1669 64442545
Venoocclusive liver disease 29.05 13.29 39 54479 9976 64434238
Graft versus host disease in lung 29.04 13.29 14 54504 790 64443424
Acanthamoeba infection 28.91 13.29 12 54506 474 64443740
Thyroid stimulating immunoglobulin increased 28.89 13.29 8 54510 87 64444127
Orthostatic hypotension 28.78 13.29 3 54515 46735 64397479
Drug exposure before pregnancy 28.69 13.29 12 54506 483 64443731
Metabolic acidosis 28.69 13.29 12 54506 70946 64373268
Leukaemia recurrent 28.64 13.29 21 54497 2573 64441641
Vomiting 28.59 13.29 313 54205 550804 63893410
Varicella 28.45 13.29 21 54497 2600 64441614
Blood pressure systolic increased 28.43 13.29 4 54514 49449 64394765
Aggression 28.39 13.29 3 54515 46229 64397985
Plasma cell myeloma 28.27 13.29 3 54515 46072 64398142
Eosinophil count decreased 28.23 13.29 21 54497 2631 64441583
Electrocardiogram QT prolonged 28.23 13.29 16 54502 79432 64364782
Infertility 28.08 13.29 12 54506 510 64443704
Immature granulocyte percentage increased 27.66 13.29 7 54511 52 64444162
Chronic hepatitis C 27.62 13.29 12 54506 531 64443683
Pulmonary embolism 27.57 13.29 51 54467 146305 64297909
Meningitis tuberculous 27.50 13.29 15 54503 1096 64443118
Rectal haemorrhage 27.44 13.29 9 54509 61808 64382406
Anaphylactic reaction 27.14 13.29 12 54506 68652 64375562
Contusion 27.07 13.29 177 54341 113788 64330426
Creatinine urine increased 27.02 13.29 11 54507 413 64443801
Feeling cold 27.01 13.29 61 54457 23617 64420597
Blood creatine phosphokinase increased 26.93 13.29 8 54510 58550 64385664
Thrombotic thrombocytopenic purpura 26.71 13.29 29 54489 5955 64438259
Infusion site discomfort 26.64 13.29 13 54505 753 64443461
Staphylococcal bacteraemia 26.55 13.29 38 54480 10317 64433897
Nocardiosis 26.51 13.29 26 54492 4741 64439473
Constipation 26.43 13.29 102 54416 229235 64214979
Vulvovaginal mycotic infection 26.41 13.29 23 54495 3605 64440609
Haemoglobin increased 26.41 13.29 27 54491 5174 64439040
Apoptosis 26.31 13.29 10 54508 312 64443902
Diplopia 26.24 13.29 65 54453 26700 64417514
Hepatitis infectious mononucleosis 26.12 13.29 8 54510 127 64444087
White blood cell count abnormal 26.11 13.29 26 54492 4828 64439386
Granulocyte count increased 25.71 13.29 13 54505 813 64443401
Hypotension 25.49 13.29 203 54315 380771 64063443
Stenotrophomonas infection 25.45 13.29 21 54497 3059 64441155
B-lymphocyte count increased 25.44 13.29 8 54510 139 64444075
Basophil count increased 25.31 13.29 15 54503 1285 64442929
Heart rate increased 25.13 13.29 156 54362 98519 64345695
Encephalitis 25.00 13.29 41 54477 12530 64431684
Fungal skin infection 24.93 13.29 26 54492 5099 64439115
Hypocalcaemia 24.91 13.29 3 54515 41750 64402464
Herpes zoster meningoencephalitis 24.87 13.29 12 54506 678 64443536
Proteinuria 24.76 13.29 65 54453 27658 64416556
Sedation 24.68 13.29 3 54515 41459 64402755
Treatment failure 24.49 13.29 38 54480 116778 64327436
Anti-glomerular basement membrane antibody 24.31 13.29 4 54514 0 64444214
Goodpasture's syndrome 24.31 13.29 4 54514 0 64444214
Anti-glomerular basement membrane antibody positive 24.31 13.29 4 54514 0 64444214
Legionella infection 24.29 13.29 12 54506 714 64443500
Laboratory test abnormal 24.19 13.29 59 54459 24004 64420210
Embryonal rhabdomyosarcoma 24.02 13.29 6 54512 42 64444172
Herpes virus infection 24.01 13.29 28 54490 6216 64437998
Treatment noncompliance 23.89 13.29 4 54514 43478 64400736
Temperature intolerance 23.72 13.29 32 54486 8223 64435991
Intentional product misuse 23.69 13.29 16 54502 72279 64371935
Stomatitis 23.61 13.29 35 54483 109570 64334644
Eosinophil count abnormal 23.49 13.29 11 54507 581 64443633
Polymyositis 23.49 13.29 19 54499 2691 64441523
Human herpesvirus 6 infection reactivation 23.47 13.29 9 54509 288 64443926
Encephalitis viral 23.46 13.29 18 54500 2362 64441852
Vitiligo 23.43 13.29 16 54502 1752 64442462
Activated partial thromboplastin time shortened 23.41 13.29 12 54506 773 64443441
Malignant neoplasm progression 23.39 13.29 37 54481 112834 64331380
Pollakiuria 23.31 13.29 69 54449 31461 64412753
Bacterial sepsis 23.11 13.29 30 54488 7427 64436787
Delirium 23.09 13.29 15 54503 69179 64375035
Coma 23.04 13.29 24 54494 87591 64356623
Respiratory arrest 23.02 13.29 8 54510 52977 64391237
Infection in an immunocompromised host 22.94 13.29 13 54505 1024 64443190
Exophthalmos 22.79 13.29 15 54503 1545 64442669
Throat irritation 22.69 13.29 70 54448 32641 64411573
Angioedema 22.62 13.29 12 54506 61809 64382405
Transient ischaemic attack 22.30 13.29 5 54513 44177 64400037
Deep vein thrombosis 22.25 13.29 34 54484 105148 64339066
Haemoglobin urine 22.03 13.29 7 54511 126 64444088
Gastrointestinal disorder 22.02 13.29 26 54492 89683 64354531
Growth failure 21.93 13.29 8 54510 222 64443992
Tuberculosis liver 21.86 13.29 6 54512 63 64444151
Klebsiella sepsis 21.86 13.29 18 54500 2614 64441600
Limb discomfort 21.56 13.29 61 54457 27114 64417100
Hypomagnesaemia 21.54 13.29 3 54515 37373 64406841
Dyspnoea 21.48 13.29 454 54064 718220 63725994
Atypical mycobacterial pneumonia 21.34 13.29 7 54511 140 64444074
Adverse drug reaction 21.30 13.29 6 54512 45458 64398756
Platelet morphology abnormal 21.29 13.29 6 54512 70 64444144
Pregnancy of partner 21.28 13.29 8 54510 242 64443972
Immune reconstitution inflammatory syndrome 21.28 13.29 38 54480 12432 64431782
Meningism 21.10 13.29 10 54508 543 64443671
Chronic lymphocytic leukaemia recurrent 20.88 13.29 10 54508 556 64443658
Infusion site scar 20.83 13.29 8 54510 257 64443957
Microangiopathy 20.72 13.29 14 54504 1507 64442707
Pancytopenia 20.48 13.29 198 54320 143111 64301103
Bronchitis 20.38 13.29 38 54480 108705 64335509
Muscle spasticity 20.20 13.29 44 54474 16625 64427589
Infusion site swelling 20.17 13.29 24 54494 5441 64438773
Diabetes mellitus 20.11 13.29 16 54502 66458 64377756
Loss of personal independence in daily activities 20.02 13.29 19 54499 72435 64371779
Lymphocyte percentage abnormal 20.02 13.29 5 54513 35 64444179
Product prescribing error 19.93 13.29 3 54515 35266 64408948
Aplasia pure red cell 19.87 13.29 27 54491 6987 64437227
Complications of bone marrow transplant 19.79 13.29 10 54508 625 64443589
Anti-thyroid antibody 19.77 13.29 5 54513 37 64444177
Loss of consciousness 19.77 13.29 62 54456 148303 64295911
Off label use 19.54 13.29 685 53833 632121 63812093
Albuminuria 19.54 13.29 10 54508 642 64443572
Drug-induced liver injury 19.35 13.29 8 54510 47635 64396579
Tri-iodothyronine free abnormal 19.32 13.29 5 54513 41 64444173
Retinal depigmentation 19.32 13.29 8 54510 314 64443900
Oedema 19.18 13.29 30 54488 91905 64352309
Type 2 diabetes mellitus 18.98 13.29 3 54515 34017 64410197
Adverse event 18.89 13.29 5 54513 39484 64404730
Pneumonia pseudomonal 18.87 13.29 22 54496 4881 64439333
Papilloma viral infection 18.81 13.29 13 54505 1451 64442763
Epstein-Barr virus associated lymphoma 18.78 13.29 11 54507 922 64443292
Chronic kidney disease 18.73 13.29 13 54505 57906 64386308
Urine uric acid increased 18.71 13.29 5 54513 47 64444167
Pulmonary haemorrhage 18.70 13.29 37 54481 13072 64431142
Injection site reaction 18.69 13.29 8 54510 46656 64397558
Accidental overdose 18.63 13.29 3 54515 33554 64410660
Quadriparesis 18.59 13.29 17 54501 2840 64441374
Enterococcal bacteraemia 18.48 13.29 16 54502 2489 64441725
Musculoskeletal pain 18.46 13.29 25 54493 81269 64362945
Ureaplasma infection 18.37 13.29 10 54508 728 64443486
Pulmonary alveolar haemorrhage 18.34 13.29 31 54487 9707 64434507
Chronic lymphocytic leukaemia refractory 18.30 13.29 6 54512 120 64444094
Pneumonia aspiration 18.26 13.29 14 54504 59257 64384957
Nitrite urine 18.09 13.29 4 54514 15 64444199
Abdominal discomfort 17.99 13.29 86 54432 182236 64261978
Hallucination 17.97 13.29 21 54497 72767 64371447
Thyroid disorder 17.90 13.29 34 54484 11658 64432556
Therapy cessation 17.83 13.29 3 54515 32486 64411728
Suicidal ideation 17.75 13.29 18 54500 66524 64377690
Citrobacter infection 17.75 13.29 10 54508 779 64443435
Pancreatitis acute 17.73 13.29 7 54511 42848 64401366
Fumbling 17.72 13.29 6 54512 133 64444081
Urine bilirubin increased 17.72 13.29 6 54512 133 64444081
Posterior reversible encephalopathy syndrome 17.71 13.29 51 54467 22895 64421319
Injection site pruritus 17.70 13.29 5 54513 37821 64406393
Viral test positive 17.65 13.29 8 54510 392 64443822
Post herpetic neuralgia 17.57 13.29 15 54503 2290 64441924
Enterobacter bacteraemia 17.54 13.29 9 54509 581 64443633
Evans syndrome 17.48 13.29 8 54510 401 64443813
Leukaemic infiltration 17.43 13.29 6 54512 140 64444074
Lymphocyte percentage increased 17.42 13.29 9 54509 589 64443625
Irritable bowel syndrome 17.38 13.29 5 54513 37364 64406850
Myositis 17.37 13.29 41 54477 16336 64427878
Cataract 17.26 13.29 11 54507 51251 64392963
Chromaturia 17.21 13.29 50 54468 22561 64421653
Glomerulonephritis chronic 17.14 13.29 7 54511 265 64443949
Infection reactivation 17.11 13.29 14 54504 2016 64442198
Paternal exposure timing unspecified 17.10 13.29 5 54513 67 64444147
Infusion site rash 17.05 13.29 11 54507 1095 64443119
Dyskinesia 17.02 13.29 6 54512 39382 64404832
Goitre 16.99 13.29 21 54497 4952 64439262
Femur fracture 16.96 13.29 4 54514 34131 64410083
Micturition urgency 16.95 13.29 31 54487 10328 64433886
Urobilinogen urine 16.84 13.29 4 54514 22 64444192
Thrombosis 16.78 13.29 21 54497 70621 64373593
Interstitial lung disease 16.73 13.29 36 54482 97696 64346518
Injection site swelling 16.70 13.29 7 54511 41346 64402868
Fungal infection 16.53 13.29 65 54453 34186 64410028
Thyroiditis subacute 16.50 13.29 7 54511 292 64443922
Urine odour abnormal 16.45 13.29 21 54497 5115 64439099
Basophil count abnormal 16.40 13.29 4 54514 25 64444189
Pancreas transplant rejection 16.35 13.29 7 54511 299 64443915
Neutrophil percentage abnormal 16.27 13.29 4 54514 26 64444188
Shock 16.23 13.29 6 54512 38234 64405980
Necrotising oesophagitis 16.21 13.29 9 54509 681 64443533
Varicella virus test positive 16.20 13.29 6 54512 174 64444040
Monocyte percentage abnormal 16.15 13.29 3 54515 3 64444211
Fibrin D dimer increased 16.15 13.29 24 54494 6741 64437473
Melaena 16.05 13.29 13 54505 53535 64390679
Fluid retention 16.04 13.29 16 54502 59590 64384624
Thrombocytopenia 16.01 13.29 272 54246 223529 64220685
Chronic lymphocytic leukaemia 16.01 13.29 19 54499 4296 64439918
Weight increased 16.00 13.29 110 54408 213238 64230976
Nystagmus 15.94 13.29 28 54490 9040 64435174
Erythema 15.89 13.29 234 54284 186836 64257378
Sinus bradycardia 15.89 13.29 49 54469 22844 64421370
Interleukin-2 receptor increased 15.79 13.29 6 54512 187 64444027
Somnolence 15.77 13.29 104 54414 203541 64240673
Stem cell transplant 15.76 13.29 17 54501 3464 64440750
JC polyomavirus test positive 15.73 13.29 11 54507 1251 64442963
Drug resistance 15.66 13.29 65 54453 35037 64409177
Cytomegalovirus chorioretinitis 15.60 13.29 20 54498 4892 64439322
Thyroid hormones increased 15.52 13.29 7 54511 339 64443875
Protein urine 15.49 13.29 11 54507 1283 64442931
Pneumocystis jirovecii pneumonia 15.47 13.29 55 54463 27579 64416635
Blood stem cell transplant failure 15.44 13.29 8 54510 527 64443687
Mycobacterium abscessus infection 15.43 13.29 10 54508 1004 64443210
Acquired haemophilia 15.42 13.29 12 54506 1608 64442606
Hepatic function abnormal 15.40 13.29 19 54499 64294 64379920
Disorder of globe 15.29 13.29 3 54515 5 64444209
Renal transplant failure 15.29 13.29 12 54506 1628 64442586
Diarrhoea haemorrhagic 15.19 13.29 31 54487 11196 64433018
Drug level increased 15.14 13.29 5 54513 34191 64410023
Periportal oedema 15.11 13.29 5 54513 103 64444111
Cardiac failure congestive 15.08 13.29 58 54460 130522 64313692
Endometrial ablation 14.96 13.29 9 54509 792 64443422
Transfusion microchimerism 14.94 13.29 3 54515 6 64444208
Eosinophil percentage abnormal 14.94 13.29 3 54515 6 64444208
Neoplasm progression 14.91 13.29 8 54510 40956 64403258
Phaeohyphomycosis 14.90 13.29 10 54508 1064 64443150
Intestinal obstruction 14.89 13.29 6 54512 36280 64407934
Emotional distress 14.72 13.29 6 54512 36032 64408182
Thyroid cyst 14.67 13.29 7 54511 386 64443828
T-cell prolymphocytic leukaemia 14.66 13.29 4 54514 41 64444173
Haematemesis 14.61 13.29 11 54507 46988 64397226
Semenuria 14.57 13.29 4 54514 42 64444172
Discomfort 14.51 13.29 29 54489 80849 64363365
Gait disturbance 14.49 13.29 215 54303 171940 64272274
Engraft failure 14.44 13.29 8 54510 603 64443611
Malignant melanoma 14.34 13.29 33 54485 12931 64431283
Hot flush 14.31 13.29 77 54441 46158 64398056
Osteoporosis 14.21 13.29 9 54509 42071 64402143
Vaccination site inflammation 14.17 13.29 4 54514 47 64444167
Cerebral toxoplasmosis 14.16 13.29 12 54506 1814 64442400
Dysgraphia 14.08 13.29 16 54502 3455 64440759
CD8 lymphocytes decreased 14.02 13.29 6 54512 256 64443958
Citric acid urine increased 13.94 13.29 4 54514 50 64444164
Pulmonary fibrosis 13.89 13.29 4 54514 29874 64414340
Infusion site bruising 13.83 13.29 11 54507 1521 64442693
Hyperoxaluria 13.82 13.29 6 54512 265 64443949
Pneumonia fungal 13.82 13.29 26 54492 8851 64435363
Graft versus host disease in liver 13.77 13.29 11 54507 1530 64442684
Dysgeusia 13.66 13.29 77 54441 46970 64397244
Nephropathy 13.60 13.29 25 54493 8361 64435853
Aspiration bone marrow abnormal 13.60 13.29 5 54513 142 64444072
White blood cell count increased 13.58 13.29 99 54419 65915 64378299
Cytomegalovirus enteritis 13.55 13.29 8 54510 680 64443534
Ventricular tachycardia 13.52 13.29 6 54512 34259 64409955
Serum amyloid A protein increased 13.50 13.29 5 54513 145 64444069
Poikilocytosis 13.45 13.29 6 54512 283 64443931
Bilirubin urine 13.41 13.29 3 54515 12 64444202
Fungal test positive 13.37 13.29 9 54509 962 64443252
Herpes zoster infection neurological 13.34 13.29 5 54513 150 64444064
Pseudomonal sepsis 13.29 13.29 19 54499 5153 64439061

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA34 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
FDA MoA N0000175079 CD52-directed Antibody Interactions
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000074322 Antineoplastic Agents, Immunological
FDA EPC N0000175659 CD52-directed Cytolytic Antibody

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Refractory chronic lymphocytic leukemia indication 92814006
Conditioning treatment prior to allogeneic haematopoietic stem cell transplant indication 234336002
Relapsing remitting multiple sclerosis indication 426373005 DOID:2378
Recurrent chronic lymphocytic leukemia indication 122961000119105




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
CAMPATH-1 antigen Surface antigen ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D02802 KEGG_DRUG
4021265 VUID
N0000148705 NUI
4021265 VANDF
CHEMBL1201587 ChEMBL_ID
6770 IUPHAR_LIGAND_ID
8005 INN_ID
DB00087 DRUGBANK_ID
3A189DH42V UNII
117055 RXNORM
16025 MMSL
213286 MMSL
41389 MMSL
d04756 MMSL
009168 NDDF
009169 NDDF
129472003 SNOMEDCT_US
391632007 SNOMEDCT_US
D000074323 MESH_DESCRIPTOR_UI
C0383429 UMLSCUI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
LEMTRADA HUMAN PRESCRIPTION DRUG LABEL 1 58468-0200 INJECTION, SOLUTION, CONCENTRATE 12 mg INTRAVENOUS BLA 29 sections
LEMTRADA HUMAN PRESCRIPTION DRUG LABEL 1 58468-0200 INJECTION, SOLUTION, CONCENTRATE 12 mg INTRAVENOUS BLA 29 sections
Campath HUMAN PRESCRIPTION DRUG LABEL 1 58468-0357 INJECTION 30 mg INTRAVENOUS BLA 28 sections