All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

natalizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
humanized origin	4970	189261-10-7

Description:

Molecule	Description
Synonyms: antegren natalizumab tysabri	A humanized monoclonal immunoglobulin G4 antibody to human INTEGRIN ALPHA4 that binds to the alpha4 subunit of INTEGRIN ALPHA4BETA1 and integrin alpha4beta7. It is used as an IMMUNOLOGIC FACTOR in the treatment of RELAPSING-REMITTING MULTIPLE SCLEROSIS and CROHN'S DISEASE. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
10	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 27, 2006	EMA
Nov. 23, 2004	FDA	BIOGEN IDEC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	12129.33	12.97	4133	94990	38831	50467170
Progressive multifocal leukoencephalopathy	3516.87	12.97	1178	97945	10279	50495722
Immune reconstitution inflammatory syndrome	2443.65	12.97	750	98373	4766	50501235
General symptom	1747.84	12.97	483	98640	1980	50504021
Urinary tract infection	1645.47	12.97	2103	97020	221917	50284084
Malaise	1200.40	12.97	2259	96864	333273	50172728
Drug specific antibody present	1123.18	12.97	369	98754	2999	50503002
Opportunistic infection	1089.59	12.97	307	98816	1371	50504630
Abortion spontaneous	1009.09	12.97	756	98367	41016	50464985
Prescribed underdose	880.11	12.97	486	98637	15463	50490538
Poor venous access	790.42	12.97	392	98731	9948	50496053
Balance disorder	654.93	12.97	748	98375	69842	50436159
Gait disturbance	583.97	12.97	1050	98073	148955	50357046
Fall	533.80	12.97	1651	97472	333281	50172720
Cognitive disorder	514.99	12.97	528	98595	43595	50462406
Memory impairment	502.76	12.97	695	98428	78665	50427336
Magnetic resonance imaging abnormal	455.69	12.97	179	98944	2539	50503462
Off label use	455.03	12.97	181	98942	474245	50031756
Central nervous system lesion	452.76	12.97	263	98860	9226	50496775
Maternal exposure during pregnancy	442.42	12.97	970	98153	158808	50347193
Seizure	397.08	12.97	776	98347	117098	50388903
Secondary progressive multiple sclerosis	391.24	12.97	131	98992	1135	50504866
Herpes zoster	381.07	12.97	574	98549	70212	50435789
Loss of control of legs	372.04	12.97	127	98996	1174	50504827
Neoplasm malignant	371.76	12.97	334	98789	23381	50482620
Breast cancer	353.47	12.97	428	98695	42462	50463539
Muscular weakness	347.61	12.97	648	98475	94365	50411636
Diarrhoea	331.15	12.97	401	98722	588075	49917926
Toxicity to various agents	316.14	12.97	27	99096	212472	50293529
Caesarean section	301.53	12.97	248	98875	15391	50490610
Optic neuritis	289.62	12.97	176	98947	6714	50499287
Joint swelling	272.64	12.97	72	99051	245214	50260787
Drug interaction	269.78	12.97	36	99087	199585	50306416
Rheumatoid arthritis	265.61	12.97	40	99083	202510	50303491
Hypoaesthesia	258.71	12.97	686	98437	126571	50379430
Muscle spasticity	257.49	12.97	236	98887	16948	50489053
Contraindicated product administered	251.87	12.97	9	99114	148949	50357052
Decubitus ulcer	250.91	12.97	181	98942	9237	50496764
Invasive ductal breast carcinoma	225.40	12.97	142	98981	5779	50500222
JC polyomavirus test positive	221.58	12.97	83	99040	1026	50504975
Product use issue	219.49	12.97	20	99103	149455	50356546
Condition aggravated	218.80	12.97	158	98965	296900	50209101
Asthenia	214.84	12.97	1208	97915	317834	50188167
Nasopharyngitis	211.57	12.97	842	98281	192085	50313916
Drug hypersensitivity	210.31	12.97	115	99008	250895	50255106
Hypersensitivity	203.91	12.97	898	98225	214263	50291738
Mobility decreased	200.35	12.97	467	98656	79481	50426520
Glossodynia	198.83	12.97	6	99117	115563	50390438
Musculoskeletal disorder	197.55	12.97	205	98918	17144	50488857
Neutralising antibodies positive	196.40	12.97	53	99070	194	50505807
Drug delivery device placement	194.79	12.97	45	99078	67	50505934
Influenza	194.51	12.97	495	98628	89043	50416958
Acute kidney injury	193.19	12.97	103	99020	227955	50278046
Abdominal discomfort	189.88	12.97	109	99014	231532	50274469
Visual impairment	187.96	12.97	414	98709	67861	50438140
Injection site pain	183.27	12.97	8	99115	111016	50394985
Gait inability	177.79	12.97	285	98838	36742	50469259
Peripheral swelling	175.89	12.97	92	99031	205844	50300157
Neutropenia	174.94	12.97	38	99085	147927	50358074
Trigeminal neuralgia	169.21	12.97	94	99029	3021	50502980
Cystitis	167.88	12.97	308	98815	44256	50461745
Stress	167.49	12.97	343	98780	53450	50452551
Progressive multiple sclerosis	167.39	12.97	61	99062	694	50505307
Febrile neutropenia	164.71	12.97	6	99117	97661	50408340
Surgery	161.05	12.97	244	98879	29961	50476040
Neuromyelitis optica spectrum disorder	158.43	12.97	60	99063	766	50505235
Hysterectomy	158.13	12.97	128	98995	7762	50498239
Dyspnoea	157.32	12.97	549	98574	547059	49958942
Road traffic accident	156.57	12.97	215	98908	24137	50481864
Product use in unapproved indication	156.10	12.97	21	99102	115798	50390203
Alopecia	154.91	12.97	151	98972	244896	50261105
Malignant melanoma	153.71	12.97	140	98983	9968	50496033
Arthralgia	150.70	12.97	405	98718	438297	50067704
Systemic lupus erythematosus	149.19	12.97	45	99078	140577	50365424
Decreased immune responsiveness	146.22	12.97	93	99030	3848	50502153
Peroneal nerve palsy	141.56	12.97	94	99029	4189	50501812
Decreased appetite	139.95	12.97	113	99010	200810	50305191
Neurogenic bladder	135.77	12.97	79	99044	2778	50503223
Mental impairment	132.97	12.97	140	98983	11904	50494097
Hemiparesis	131.90	12.97	179	98944	19869	50486132
Vein disorder	131.30	12.97	90	99033	4229	50501772
Nausea	131.28	12.97	828	98295	704570	49801431
Weight increased	126.86	12.97	125	98998	201766	50304235
Swelling	125.49	12.97	125	98998	200747	50305254
Epilepsy	121.80	12.97	179	98944	21388	50484613
Drug intolerance	120.83	12.97	151	98972	218953	50287048
Exposure during pregnancy	120.83	12.97	43	99080	120972	50385029
Injection site erythema	115.60	12.97	8	99115	74928	50431073
Coordination abnormal	113.20	12.97	126	98997	11408	50494593
Intraductal proliferative breast lesion	109.38	12.97	66	99057	2484	50503517
Rash	103.58	12.97	473	98650	436998	50069003
Ankle fracture	102.85	12.97	140	98983	15582	50490419
Lower limb fracture	102.65	12.97	133	98990	14113	50491888
Pancytopenia	102.55	12.97	20	99103	84010	50421991
Intervertebral disc protrusion	102.05	12.97	160	98963	20233	50485768
Urosepsis	101.61	12.97	138	98985	15327	50490674
Stomatitis	101.18	12.97	36	99087	101308	50404693
Arthropathy	100.05	12.97	97	99026	157809	50348192
Completed suicide	99.76	12.97	68	99055	131821	50374180
Pericarditis	99.75	12.97	17	99106	78672	50427329
Therapeutic product effect incomplete	99.39	12.97	28	99095	91487	50414514
Hyponatraemia	97.96	12.97	33	99090	96106	50409895
Aphasia	97.43	12.97	189	98934	28305	50477696
Hospitalisation	97.27	12.97	10	99113	67927	50438074
Bladder disorder	96.60	12.97	95	99028	7448	50498553
Multiple sclerosis	93.27	12.97	154	98969	20339	50485662
Depression	89.79	12.97	593	98530	164830	50341171
Blood creatinine increased	89.08	12.97	20	99103	76140	50429861
Central venous catheterisation	88.46	12.97	54	99069	2076	50503925
Uterine leiomyoma	87.59	12.97	92	99031	7799	50498202
Thrombocytopenia	87.35	12.97	73	99050	127600	50378401
Loss of personal independence in daily activities	86.90	12.97	16	99107	70034	50435967
Speech disorder	86.09	12.97	205	98918	35343	50470658
Atrial fibrillation	85.97	12.97	46	99077	101699	50404302
Diplopia	85.33	12.97	143	98980	19117	50486884
C-reactive protein increased	85.05	12.97	14	99109	66460	50439541
Relapsing-remitting multiple sclerosis	84.90	12.97	33	99090	454	50505547
Breech presentation	84.40	12.97	42	99081	1072	50504929
Upper respiratory tract infection	83.93	12.97	302	98821	65596	50440405
Platelet count decreased	82.99	12.97	47	99076	100679	50405322
Disease progression	82.99	12.97	42	99081	95824	50410177
Adverse reaction	82.89	12.97	93	99030	8493	50497508
Cervical dysplasia	82.22	12.97	57	99066	2728	50503273
Haemoglobin decreased	81.91	12.97	77	99046	127139	50378862
Bronchitis	81.79	12.97	412	98711	103747	50402254
Electrocardiogram QT prolonged	81.62	12.97	5	99118	51881	50454120
Hip fracture	81.44	12.97	166	98957	25765	50480236
Vomiting	81.25	12.97	549	98574	460209	50045792
Abdominal pain	80.95	12.97	218	98905	236010	50269991
Lower respiratory tract infection	80.49	12.97	43	99080	95158	50410843
Thyroid cancer	80.10	12.97	66	99057	4103	50501898
Wrong technique in product usage process	79.91	12.97	8	99115	55502	50450499
No adverse event	77.41	12.97	190	98933	33388	50472613
Treatment failure	76.71	12.97	94	99029	137543	50368458
Nephrolithiasis	76.50	12.97	193	98930	34500	50471501
Blister	76.09	12.97	36	99087	85382	50420619
Renal impairment	75.30	12.97	27	99096	75634	50430367
Prolonged labour	74.56	12.97	31	99092	513	50505488
Ectopic pregnancy	74.33	12.97	50	99073	2277	50503724
Gastric bypass	74.04	12.97	42	99081	1406	50504595
Intentional overdose	73.93	12.97	16	99107	62488	50443513
Leukopenia	72.69	12.97	21	99102	67507	50438494
Intentional product use issue	72.32	12.97	30	99093	76888	50429113
Anaphylactic shock	71.74	12.97	136	98987	20019	50485982
Pleural effusion	71.53	12.97	35	99088	81419	50424582
Mental disorder	70.51	12.97	142	98981	21849	50484152
Pregnancy	69.93	12.97	169	98954	29408	50476593
Muscle spasms	69.25	12.97	452	98671	125101	50380900
Neuropathy peripheral	69.08	12.97	53	99070	96704	50409297
Anaemia	68.93	12.97	258	98865	252198	50253803
Helicobacter infection	66.96	12.97	9	99114	49693	50456308
Infection	66.67	12.97	572	98551	172382	50333619
JC virus granule cell neuronopathy	66.64	12.97	20	99103	116	50505885
White blood cell count increased	66.56	12.97	208	98915	42032	50463969
Infusion site extravasation	66.39	12.97	75	99048	6901	50499100
Psoriasis	66.36	12.97	26	99097	68974	50437027
Cardiac failure	66.28	12.97	33	99090	76007	50429994
Kidney infection	66.12	12.97	126	98997	18620	50487381
Migraine	65.71	12.97	307	98816	74973	50431028
Cervix carcinoma	65.62	12.97	48	99075	2502	50503499
Hypotension	64.69	12.97	240	98883	235229	50270772
Drug abuse	63.70	12.97	19	99104	59827	50446174
Dyspepsia	63.32	12.97	33	99090	74064	50431937
Urinary incontinence	63.31	12.97	158	98965	28050	50477951
Injection site reaction	62.98	12.97	11	99112	50021	50455980
Dyspnoea exertional	62.91	12.97	12	99111	51221	50454780
Herpes zoster necrotising retinopathy	62.85	12.97	12	99111	0	50506001
White blood cell count decreased	62.66	12.97	82	99041	116640	50389361
Therapeutic response decreased	62.58	12.97	9	99114	47222	50458779
Post lumbar puncture syndrome	62.55	12.97	28	99095	559	50505442
Lymphocytosis	62.51	12.97	44	99079	2158	50503843
Staphylococcal infection	62.35	12.97	182	98941	35434	50470567
Dysgraphia	61.39	12.97	47	99076	2626	50503375
Multiple organ dysfunction syndrome	61.36	12.97	12	99111	50325	50455676
Unevaluable event	60.52	12.97	9	99114	46057	50459944
Amnesia	60.17	12.97	201	98922	42059	50463942
Muscle injury	60.15	12.97	3	99120	37108	50468893
Cough	59.88	12.97	256	98867	241008	50264993
Constipation	59.43	12.97	177	98946	185531	50320470
Oxygen saturation decreased	59.16	12.97	35	99088	73213	50432788
Temperature intolerance	58.44	12.97	73	99050	7466	50498535
Incorrect dose administered	58.06	12.97	12	99111	48402	50457599
Breast cancer female	57.33	12.97	69	99054	6793	50499208
Epistaxis	56.88	12.97	27	99096	63927	50442074
Vision blurred	56.81	12.97	304	98819	78343	50427658
Hypoxia	56.70	12.97	15	99108	51108	50454893
Intentional product misuse	55.19	12.97	12	99111	46722	50459279
Gallbladder operation	54.60	12.97	39	99084	1958	50504043
Discomfort	53.33	12.97	81	99042	108299	50397702
Neutrophil count decreased	52.01	12.97	13	99110	46013	50459988
Focal dyscognitive seizures	51.96	12.97	43	99080	2689	50503312
Death	51.09	12.97	908	98215	324471	50181530
Pharyngitis streptococcal	51.02	12.97	74	99049	8734	50497267
Breast cancer stage I	50.17	12.97	37	99086	1953	50504048
Invasive lobular breast carcinoma	49.82	12.97	25	99098	650	50505351
Viral infection	49.42	12.97	150	98973	29836	50476165
Band sensation	49.30	12.97	25	99098	665	50505336
International normalised ratio increased	49.13	12.97	12	99111	43140	50462861
Weight decreased	48.25	12.97	246	98877	220999	50285002
Dysstasia	47.80	12.97	107	99016	17712	50488289
Lactic acidosis	47.50	12.97	5	99118	33350	50472651
Frustration tolerance decreased	47.31	12.97	57	99066	5617	50500384
Gastroenteritis viral	47.28	12.97	110	99013	18676	50487325
Foetal exposure timing unspecified	47.16	12.97	17	99106	187	50505814
Hypoglycaemia	47.07	12.97	23	99100	53558	50452443
Primary progressive multiple sclerosis	46.97	12.97	14	99109	79	50505922
Appendicitis perforated	46.67	12.97	32	99091	1504	50504497
Cardio-respiratory arrest	46.05	12.97	24	99099	53868	50452133
Tachycardia	45.85	12.97	78	99045	99685	50406316
Partial seizures	45.78	12.97	52	99071	4813	50501188
Red blood cell sedimentation rate increased	45.77	12.97	3	99120	29413	50476588
Upper limb fracture	45.62	12.97	98	99025	15775	50490226
Papillary thyroid cancer	45.34	12.97	35	99088	1980	50504021
Gastrointestinal haemorrhage	45.29	12.97	46	99077	73275	50432726
Somnolence	45.17	12.97	154	98969	154831	50351170
Clostridial infection	45.14	12.97	47	99076	3943	50502058
Ascites	44.88	12.97	8	99115	35853	50470148
Urticaria	44.51	12.97	418	98705	129143	50376858
Endometriosis	44.32	12.97	47	99076	4028	50501973
Head injury	44.22	12.97	125	98998	23895	50482106
Rhabdomyolysis	44.14	12.97	11	99112	39016	50466985
Drug reaction with eosinophilia and systemic symptoms	43.93	12.97	3	99120	28421	50477580
Sensory disturbance	43.57	12.97	81	99042	11748	50494253
Therapy non-responder	43.18	12.97	23	99100	50999	50455002
Antibody test positive	43.18	12.97	36	99087	2275	50503726
Escherichia urinary tract infection	43.17	12.97	75	99048	10320	50495681
Central nervous system lymphoma	42.81	12.97	29	99094	1336	50504665
Productive cough	42.80	12.97	25	99098	52669	50453332
Folliculitis	42.57	12.97	12	99111	39213	50466788
Myalgia	42.32	12.97	115	99008	124204	50381797
Blood pressure systolic increased	42.07	12.97	9	99114	35440	50470561
Metabolic acidosis	41.91	12.97	12	99111	38813	50467188
Bladder dysfunction	41.74	12.97	23	99100	727	50505274
Neurological symptom	41.47	12.97	48	99075	4534	50501467
Hyperhidrosis	41.01	12.97	70	99053	89356	50416645
Interstitial lung disease	40.74	12.97	27	99096	53149	50452852
Wound	40.59	12.97	92	99031	105702	50400299
Hypokalaemia	40.24	12.97	69	99054	87923	50418078
Meningioma	39.69	12.97	41	99082	3408	50502593
Hemianaesthesia	39.64	12.97	18	99105	372	50505629
Meningitis herpes	39.50	12.97	15	99108	193	50505808
Bipolar disorder	39.47	12.97	57	99066	6700	50499301
Renal failure	39.09	12.97	95	99028	106538	50399463
Adenocarcinoma of colon	38.99	12.97	33	99090	2129	50503872
Agraphia	38.82	12.97	10	99113	29	50505972
Cardiac failure congestive	38.75	12.97	66	99057	84316	50421685
Basal cell carcinoma	38.64	12.97	117	99006	23239	50482762
Hypertension	37.91	12.97	250	98873	210953	50295048
Medication error	37.45	12.97	12	99111	36092	50469909
Abdominal distension	37.31	12.97	53	99070	72850	50433151
Inflammation	37.13	12.97	34	99089	56878	50449123
Malignant melanoma in situ	37.06	12.97	22	99101	803	50505198
Blindness	36.95	12.97	95	99028	17174	50488827
Uhthoff's phenomenon	36.66	12.97	7	99116	0	50506001
Urostomy	36.66	12.97	7	99116	0	50506001
Abortion missed	36.64	12.97	28	99095	1560	50504441
Pain	36.23	12.97	861	98262	578042	49927959
Dry mouth	36.14	12.97	34	99089	56144	50449857
Ataxia	36.10	12.97	82	99041	13704	50492297
Wheezing	36.02	12.97	41	99082	62006	50443995
Oedema	35.94	12.97	51	99072	70130	50435871
Steroid therapy	35.39	12.97	11	99112	73	50505928
Chronic kidney disease	35.04	12.97	17	99106	39754	50466247
Ophthalmic herpes zoster	35.00	12.97	28	99095	1669	50504332
Blood creatine phosphokinase increased	34.98	12.97	5	99118	26362	50479639
Chronic lymphocytic leukaemia	34.85	12.97	32	99091	2301	50503700
Bradycardia	34.83	12.97	45	99078	64381	50441620
Breast cancer in situ	34.72	12.97	26	99097	1405	50504596
Meningoencephalitis herpetic	34.16	12.97	23	99100	1049	50504952
Female reproductive tract disorder	34.07	12.97	16	99107	358	50505643
Ovarian cancer	33.90	12.97	46	99077	5103	50500898
Oedema peripheral	33.64	12.97	177	98946	157784	50348217
Herpes zoster meningitis	33.61	12.97	10	99113	56	50505945
Melaena	33.60	12.97	6	99117	26858	50479143
Motor dysfunction	33.42	12.97	58	99065	7973	50498028
Blindness unilateral	33.31	12.97	46	99077	5189	50500812
Female genital operation	33.14	12.97	8	99115	16	50505985
Sinusitis	33.05	12.97	493	98630	170065	50335936
Dry skin	32.99	12.97	22	99101	43169	50462832
Nasal congestion	32.81	12.97	31	99092	51089	50454912
Bone marrow failure	32.80	12.97	7	99116	27617	50478384
Urinary tract infection pseudomonal	32.66	12.97	20	99103	773	50505228
Arthropod bite	32.44	12.97	49	99074	5996	50500005
Gastrooesophageal reflux disease	32.21	12.97	63	99060	76365	50429636
Irritable bowel syndrome	32.08	12.97	32	99091	51409	50454592
Abdominal pain upper	32.01	12.97	182	98941	159127	50346874
Lung adenocarcinoma	32.00	12.97	40	99083	4094	50501907
Skin exfoliation	31.76	12.97	13	99110	33599	50472402
Influenza like illness	31.73	12.97	207	98916	57252	50448749
Foot fracture	31.70	12.97	99	99024	19992	50486009
Tremor	31.48	12.97	354	98769	114549	50391452
Fibula fracture	31.45	12.97	34	99089	2978	50503023
Vaginal infection	31.29	12.97	49	99074	6187	50499814
Hypervolaemia	31.24	12.97	6	99117	25493	50480508
Cholestasis	31.07	12.97	6	99117	25395	50480606
Tibia fracture	31.02	12.97	41	99082	4434	50501567
Meningitis viral	31.02	12.97	23	99100	1224	50504777
Cholecystectomy	30.93	12.97	61	99062	9242	50496759
Therapeutic product effect decreased	30.93	12.97	149	98974	135901	50370100
Injection site haemorrhage	30.92	12.97	3	99120	21343	50484658
Post procedural infection	30.60	12.97	54	99069	7522	50498479
Adverse drug reaction	30.53	12.97	199	98924	55023	50450978
Depressed level of consciousness	30.51	12.97	34	99089	51919	50454082
Therapeutic procedure	30.27	12.97	19	99104	768	50505233
Paraparesis	30.23	12.97	28	99095	2036	50503965
Blood urea increased	30.09	12.97	5	99118	23580	50482421
Paraesthesia	30.07	12.97	364	98759	119879	50386122
Papilloma viral infection	30.06	12.97	23	99100	1284	50504717
Serotonin syndrome	29.89	12.97	6	99117	24707	50481294
Autoimmune hepatitis	29.60	12.97	53	99070	7466	50498535
Blood cholesterol increased	29.40	12.97	39	99084	55176	50450825
Foetal malposition	29.32	12.97	9	99114	57	50505944
Stevens-Johnson syndrome	29.15	12.97	4	99119	21748	50484253
Appendicitis	29.09	12.97	49	99074	6575	50499426
Blood pressure increased	29.00	12.97	148	98975	132984	50373017
Sleep disorder	28.96	12.97	42	99081	57241	50448760
Colon cancer	28.91	12.97	57	99066	8634	50497367
Pruritus allergic	28.63	12.97	21	99102	1099	50504902
Arrested labour	28.57	12.97	12	99111	204	50505797
Back disorder	28.54	12.97	59	99064	9246	50496755
Oral pain	28.42	12.97	7	99116	25026	50480975
Cellulitis	28.20	12.97	236	98887	70562	50435439
Dysarthria	27.96	12.97	146	98977	37257	50468744
Fluid retention	27.76	12.97	35	99088	50614	50455387
Rectal haemorrhage	27.66	12.97	21	99102	38537	50467464
Red blood cell nucleated morphology present	27.51	12.97	7	99116	19	50505982
Neutralising antibodies	27.48	12.97	8	99115	41	50505960
Herpes simplex encephalitis	27.36	12.97	13	99110	299	50505702
Herpes simplex meningitis	27.32	12.97	8	99115	42	50505959
Accidental exposure to product	27.06	12.97	6	99117	23051	50482950
Mammoplasty	26.89	12.97	15	99108	486	50505515
Incontinence	26.82	12.97	60	99063	9925	50496076
Plasma cell myeloma	26.68	12.97	14	99109	31308	50474693
Progressive relapsing multiple sclerosis	26.52	12.97	7	99116	23	50505978
Low birth weight baby	26.49	12.97	44	99079	5837	50500164
Major depression	26.44	12.97	48	99075	6836	50499165
Hepatocellular injury	26.25	12.97	9	99114	25938	50480063
Mouth ulceration	26.22	12.97	11	99112	28013	50477988
Palpitations	26.12	12.97	96	99027	94410	50411591
Circulatory collapse	26.05	12.97	4	99119	19996	50486005
Hypocalcaemia	25.95	12.97	10	99113	26806	50479195
Headache	25.89	12.97	1226	97897	505309	50000692
Tenderness	25.89	12.97	3	99120	18562	50487439
Ejection fraction decreased	25.80	12.97	3	99120	18517	50487484
Hypercalcaemia	25.61	12.97	7	99116	23345	50482656
Sedation	25.60	12.97	14	99109	30596	50475405
Product administration error	25.53	12.97	4	99119	19695	50486306
Colon cancer metastatic	25.46	12.97	19	99104	1021	50504980
Anal incontinence	25.40	12.97	64	99059	11426	50494575
Post procedural complication	25.30	12.97	76	99047	15028	50490973
Overdose	25.20	12.97	105	99018	99622	50406379
Multiple allergies	25.18	12.97	53	99070	8410	50497591
Postoperative wound infection	25.13	12.97	53	99070	8422	50497579
Fibroadenoma of breast	25.12	12.97	13	99110	361	50505640
Rhinorrhoea	24.93	12.97	39	99084	51544	50454457
Depression suicidal	24.87	12.97	22	99101	1507	50504494
Drug level increased	24.77	12.97	4	99119	19264	50486737
Hyperglycaemia	24.65	12.97	21	99102	36384	50469617
Human papilloma virus test positive	24.54	12.97	14	99109	474	50505527
Blindness transient	24.53	12.97	31	99092	3207	50502794
Fatigue	24.21	12.97	1651	97472	705950	49800051
Therapy interrupted	24.15	12.97	5	99118	20147	50485854
Bladder catheterisation	24.06	12.97	11	99112	231	50505770
Knee operation	24.05	12.97	38	99085	4835	50501166
Flatulence	23.88	12.97	14	99109	29444	50476557
JC polyomavirus test	23.87	12.97	7	99116	37	50505964
Incorrect route of product administration	23.72	12.97	4	99119	18662	50487339
Dry eye	23.64	12.97	17	99106	32078	50473923
Delirium	23.54	12.97	24	99099	38168	50467833
Infectious mononucleosis	23.25	12.97	22	99101	1644	50504357
Plasmablastic lymphoma	23.18	12.97	10	99113	182	50505819
Pneumonia aspiration	23.16	12.97	121	99002	30883	50475118
Pulmonary hypertension	22.97	12.97	19	99104	33398	50472603
Blood glucose increased	22.77	12.97	68	99055	71256	50434745
Injury	22.70	12.97	38	99085	48887	50457114
Precancerous cells present	22.55	12.97	19	99104	1218	50504783
Metastases to bone	22.55	12.97	4	99119	17991	50488010
Cardiac arrest	22.45	12.97	86	99037	83565	50422436
Haemoptysis	22.42	12.97	11	99112	25562	50480439
Dysphemia	22.30	12.97	25	99098	2281	50503720
Uterine cancer	21.99	12.97	32	99091	3788	50502213
Lymphocyte count increased	21.90	12.97	28	99095	2931	50503070
Hypomagnesaemia	21.81	12.97	9	99114	23147	50482854
Fibromyalgia	21.74	12.97	34	99089	44944	50461057
Pain in jaw	21.65	12.97	26	99097	38402	50467599
Bile acid malabsorption	21.53	12.97	9	99114	151	50505850
Catheter placement	21.40	12.97	23	99100	2001	50504000
Myelitis transverse	21.34	12.97	17	99106	1007	50504994
Vertigo	21.29	12.97	174	98949	51658	50454343
Pneumonia	21.28	12.97	925	98198	377476	50128525
Pneumonitis	21.26	12.97	16	99107	29494	50476507
CD4 lymphocytes decreased	21.25	12.97	19	99104	1320	50504681
Blood lactate dehydrogenase increased	21.20	12.97	6	99117	19556	50486445
Inappropriate schedule of product administration	21.16	12.97	71	99052	71760	50434241
Ventricular tachycardia	20.99	12.97	3	99120	15818	50490183
Tooth infection	20.86	12.97	68	99055	14044	50491957
Anembryonic gestation	20.81	12.97	13	99110	521	50505480
Erythema	20.74	12.97	185	98938	146229	50359772
Perinatal stroke	20.71	12.97	5	99118	10	50505991
Concussion	20.67	12.97	46	99077	7582	50498419
Myelitis	20.56	12.97	18	99105	1216	50504785
Immune system disorder	20.55	12.97	48	99075	8169	50497832
Drug ineffective for unapproved indication	20.49	12.97	8	99115	21273	50484728
Colour blindness acquired	20.47	12.97	7	99116	65	50505936
Blood pressure diastolic decreased	20.45	12.97	4	99119	16777	50489224
Blood pressure fluctuation	20.43	12.97	24	99099	35799	50470202
Mammogram abnormal	20.42	12.97	14	99109	658	50505343
Pineal gland cyst	20.39	12.97	5	99118	11	50505990
Infusion site haematoma	20.39	12.97	10	99113	247	50505754
Cervix carcinoma stage III	20.26	12.97	6	99117	33	50505968
Rebound effect	20.25	12.97	28	99095	3161	50502840
Drug resistance	20.25	12.97	6	99117	18983	50487018
Face oedema	20.23	12.97	5	99118	17834	50488167
Neurogenic bowel	20.20	12.97	8	99115	116	50505885
Animal bite	20.10	12.97	24	99099	2343	50503658
Pulmonary oedema	20.05	12.97	41	99082	48897	50457104
Tubulointerstitial nephritis	19.91	12.97	3	99120	15208	50490793
Paternal exposure before pregnancy	19.82	12.97	6	99117	36	50505965
Insomnia	19.81	12.97	233	98890	174632	50331369
Product administered to patient of inappropriate age	19.64	12.97	25	99098	2605	50503396
Hepatic function abnormal	19.62	12.97	21	99102	32660	50473341
Gastric banding	19.58	12.97	7	99116	75	50505926
Flushing	19.50	12.97	209	98914	66806	50439195
Gastroenteritis cryptosporidial	19.50	12.97	7	99116	76	50505925
Endometrial cancer	19.35	12.97	26	99097	2857	50503144
Pyelonephritis	19.33	12.97	69	99054	14920	50491081
Respiratory tract infection	19.32	12.97	118	99005	31899	50474102
Ear infection	19.15	12.97	101	99022	25869	50480132
Lung cancer metastatic	19.04	12.97	23	99100	2272	50503729
Bone pain	18.99	12.97	40	99083	47189	50458812
Quadriplegia	18.96	12.97	20	99103	1703	50504298
Post-traumatic headache	18.81	12.97	5	99118	17	50505984
Abortion	18.80	12.97	22	99101	2102	50503899
Orthostatic hypotension	18.77	12.97	18	99105	29463	50476538
Joint stiffness	18.73	12.97	19	99104	30289	50475712
Impaired self-care	18.70	12.97	20	99103	1731	50504270
Cervical spinal stenosis	18.68	12.97	21	99102	1922	50504079
Injection site mass	18.56	12.97	4	99119	15676	50490325
Feeling hot	18.55	12.97	136	98987	39066	50466935
Ovarian cystectomy	18.53	12.97	8	99115	146	50505855
Dysplastic naevus	18.53	12.97	8	99115	146	50505855
Magnetic resonance imaging head abnormal	18.45	12.97	20	99103	1757	50504244
Haematuria	18.31	12.97	14	99109	25599	50480402
Incorrect drug administration rate	18.26	12.97	24	99099	2582	50503419
Medical device change	18.21	12.97	10	99113	314	50505687
Partial seizures with secondary generalisation	18.15	12.97	10	99113	316	50505685
Hyperemesis gravidarum	18.14	12.97	12	99111	531	50505470
Gastrointestinal viral infection	18.13	12.97	15	99108	938	50505063
Ligament rupture	18.06	12.97	24	99099	2610	50503391
Diplegia	17.95	12.97	15	99108	951	50505050
Haemorrhage	17.75	12.97	50	99073	53391	50452610
Agitation	17.69	12.97	50	99073	53334	50452667
Restlessness	17.69	12.97	14	99109	25159	50480842
Frequent bowel movements	17.64	12.97	3	99120	13915	50492086
Lumbar puncture	17.62	12.97	6	99117	55	50505946
Night sweats	17.58	12.97	24	99099	33550	50472451
Muscle tightness	17.48	12.97	52	99071	10228	50495773
Osteoarthritis	17.47	12.97	72	99051	68534	50437467
Blepharospasm	17.41	12.97	25	99098	2923	50503078
Foetal heart rate deceleration abnormality	17.40	12.97	11	99112	450	50505551
Incision site pain	17.35	12.97	15	99108	996	50505005
Dysgeusia	17.35	12.97	31	99092	38885	50467116
Metastatic malignant melanoma	17.34	12.97	16	99107	1158	50504843
Appendicectomy	17.32	12.97	23	99100	2499	50503502
Micturition urgency	17.20	12.97	45	99078	8219	50497782
Generalised tonic-clonic seizure	17.18	12.97	99	99024	26211	50479790
Disease recurrence	17.07	12.97	9	99114	20072	50485929
Benign neoplasm	17.01	12.97	14	99109	869	50505132
Post procedural pneumonia	16.96	12.97	5	99118	27	50505974
Synovial sarcoma	16.96	12.97	5	99118	27	50505974
Panic attack	16.95	12.97	79	99044	19263	50486738
Status migrainosus	16.83	12.97	7	99116	116	50505885
Neuralgia	16.80	12.97	86	99037	21777	50484224
Squamous cell carcinoma of the cervix	16.76	12.97	9	99114	270	50505731
Sputum discoloured	16.74	12.97	3	99120	13392	50492609
Ligament sprain	16.73	12.97	52	99071	10473	50495528
Haematochezia	16.69	12.97	33	99090	39849	50466152
Pulmonary fibrosis	16.66	12.97	14	99109	24423	50481578
Conversion disorder	16.64	12.97	18	99105	1578	50504423
Cervicitis human papilloma virus	16.57	12.97	4	99119	8	50505993
Endometrial adenocarcinoma	16.56	12.97	15	99108	1060	50504941
Shock	16.48	12.97	10	99113	20640	50485361
Proteinuria	16.37	12.97	6	99117	16591	50489410
Withdrawal syndrome	16.30	12.97	7	99116	17583	50488418
Inappropriate antidiuretic hormone secretion	16.30	12.97	3	99120	13140	50492861
Herpes virus infection	16.22	12.97	32	99091	4849	50501152
Sinus tachycardia	16.14	12.97	11	99112	21343	50484658
Impaired healing	16.10	12.97	76	99047	69710	50436291
Joint effusion	16.09	12.97	3	99120	13018	50492983
Necrotising retinitis	16.06	12.97	9	99114	294	50505707
Cephalo-pelvic disproportion	15.98	12.97	8	99115	207	50505794
Paralysis	15.86	12.97	45	99078	8619	50497382
Pericardial effusion	15.86	12.97	16	99107	25573	50480428
Status epilepticus	15.85	12.97	60	99063	13346	50492655
Nutritional supplementation	15.71	12.97	3	99120	0	50506001
Gestational oedema	15.71	12.97	3	99120	0	50506001
Detrusor sphincter dyssynergia	15.71	12.97	3	99120	0	50506001
Iron metabolism disorder	15.71	12.97	3	99120	0	50506001
Intracranial haemangioma	15.71	12.97	3	99120	0	50506001
Borderline ovarian tumour	15.71	12.97	3	99120	0	50506001
Bed bug infestation	15.71	12.97	3	99120	0	50506001
Malignant melanoma stage I	15.62	12.97	5	99118	37	50505964
Disseminated intravascular coagulation	15.59	12.97	7	99116	17128	50488873
Bladder repair	15.54	12.97	6	99117	81	50505920
Lung adenocarcinoma stage IV	15.53	12.97	7	99116	142	50505859
Angina pectoris	15.53	12.97	17	99106	26171	50479830
Autoimmune haemolytic anaemia	15.50	12.97	28	99095	3971	50502030
Cholecystitis infective	15.47	12.97	17	99106	1517	50504484
Haematemesis	15.36	12.97	19	99104	27706	50478295
Cardiomegaly	15.34	12.97	6	99117	15939	50490062
Rash erythematous	15.32	12.97	28	99095	34824	50471177
Calculus bladder	15.30	12.97	11	99112	558	50505443
Metabolic surgery	15.28	12.97	14	99109	1004	50504997
Corneal decompensation	15.28	12.97	5	99118	40	50505961
Urinary tract disorder	15.27	12.97	21	99102	2359	50503642
Thermal burn	15.21	12.97	31	99092	4810	50501191
Sepsis	15.16	12.97	354	98769	132571	50373430
Brain stem syndrome	15.08	12.97	9	99114	332	50505669
Red blood cell count decreased	15.04	12.97	27	99096	33808	50472193
Herpes zoster infection neurological	15.02	12.97	7	99116	154	50505847
Prescribed overdose	14.88	12.97	5	99118	14595	50491406
Demyelination	14.85	12.97	35	99088	5991	50500010
Liver injury	14.82	12.97	16	99107	24790	50481211
Latent tuberculosis	14.71	12.97	20	99103	2223	50503778
Bursitis	14.70	12.97	13	99110	22122	50483879
Skin discolouration	14.68	12.97	26	99097	32731	50473270
Bladder spasm	14.68	12.97	16	99107	1414	50504587
Wound sepsis	14.65	12.97	7	99116	163	50505838
Imminent abortion	14.54	12.97	4	99119	16	50505985
Macular degeneration	14.54	12.97	5	99118	14383	50491618
Urinary tract infection staphylococcal	14.51	12.97	8	99115	253	50505748
Blood potassium increased	14.46	12.97	7	99116	16391	50489610
Blood albumin decreased	14.45	12.97	4	99119	13232	50492769
Expanded disability status scale score increased	14.40	12.97	9	99114	361	50505640
Transverse presentation	14.35	12.97	4	99119	17	50505984
Goitre	14.33	12.97	32	99091	5288	50500713
Infected skin ulcer	14.32	12.97	19	99104	2062	50503939
Pertussis	14.18	12.97	11	99112	627	50505374
Eye irritation	14.10	12.97	8	99115	17132	50488869
Drug withdrawal syndrome	14.09	12.97	17	99106	25064	50480937
Blood alkaline phosphatase increased	14.09	12.97	33	99090	37493	50468508
Tooth abscess	13.93	12.97	56	99067	12804	50493197
Accident	13.93	12.97	31	99092	5110	50500891
Ovarian mass	13.92	12.97	11	99112	644	50505357
Medical device removal	13.91	12.97	14	99109	1128	50504873
Astrocytoma malignant	13.82	12.97	4	99119	20	50505981
Pruritus	13.71	12.97	437	98686	283131	50222870
Oral infection	13.71	12.97	27	99096	4087	50501914
Nucleated red cells	13.64	12.97	3	99120	3	50505998
Gastrointestinal lymphoma	13.56	12.97	5	99118	59	50505942
Cellulitis staphylococcal	13.54	12.97	11	99112	670	50505331
Uterine cyst	13.51	12.97	9	99114	403	50505598
Cervix carcinoma stage I	13.51	12.97	4	99119	22	50505979
Hot flush	13.46	12.97	43	99080	44126	50461875
Proteus infection	13.40	12.97	12	99111	835	50505166
Septic shock	13.34	12.97	62	99061	57113	50448888
Ovarian neoplasm	13.34	12.97	12	99111	840	50505161
Pneumocystis jirovecii pneumonia	13.33	12.97	6	99117	14657	50491344
Vestibular neuronitis	13.33	12.97	10	99113	542	50505459
Paraplegia	13.32	12.97	20	99103	2434	50503567
H1N1 influenza	13.24	12.97	16	99107	1581	50504420
Emotional disorder	13.19	12.97	52	99071	11784	50494217
Tumefactive multiple sclerosis	13.19	12.97	5	99118	64	50505937
Relapsing multiple sclerosis	13.17	12.97	6	99117	125	50505876
Metastases to liver	13.12	12.97	12	99111	20092	50485909
Precancerous skin lesion	13.10	12.97	12	99111	860	50505141
Communication disorder	13.10	12.97	19	99104	2242	50503759
Type 2 diabetes mellitus	13.09	12.97	30	99093	34345	50471656
Clumsiness	13.00	12.97	17	99106	1819	50504182
Procedural complication	12.98	12.97	29	99094	4794	50501207

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	4478.49	15.56	1209	28010	10210	29535098
Progressive multifocal leukoencephalopathy	1766.46	15.56	554	28665	8165	29537143
Immune reconstitution inflammatory syndrome	900.44	15.56	325	28894	7477	29537831
Urinary tract infection	733.53	15.56	591	28628	71763	29473545
General symptom	669.60	15.56	157	29062	671	29544637
Opportunistic infection	379.26	15.56	113	29106	1376	29543932
Drug specific antibody present	357.50	15.56	123	29096	2438	29542870
Malaise	333.55	15.56	578	28641	159024	29386284
Gait disturbance	322.10	15.56	379	28840	72970	29472338
Prescribed underdose	285.87	15.56	144	29075	7642	29537666
Cognitive disorder	243.71	15.56	195	29024	23304	29522004
Balance disorder	240.26	15.56	233	28986	35937	29509371
Memory impairment	238.63	15.56	233	28986	36237	29509071
Fall	228.79	15.56	525	28694	176653	29368655
Magnetic resonance imaging abnormal	227.22	15.56	77	29142	1454	29543854
Secondary progressive multiple sclerosis	227.10	15.56	56	29163	308	29545000
Muscle spasticity	226.52	15.56	106	29113	4777	29540531
JC polyomavirus test positive	201.61	15.56	56	29163	520	29544788
Muscular weakness	199.84	15.56	275	28944	61777	29483531
Mobility decreased	195.90	15.56	179	29040	25601	29519707
Loss of control of legs	168.37	15.56	48	29171	494	29544814
Poor venous access	166.61	15.56	75	29144	3086	29542222
Drug interaction	162.06	15.56	8	29211	197377	29347931
Gait inability	150.24	15.56	133	29086	18242	29527066
Central nervous system lesion	149.46	15.56	84	29135	5564	29539744
Seizure	140.26	15.56	294	28925	92829	29452479
Decubitus ulcer	131.88	15.56	85	29134	7226	29538082
Herpes zoster	126.17	15.56	152	29067	29900	29515408
Urosepsis	123.93	15.56	95	29124	10651	29534657
Off label use	118.39	15.56	76	29143	300724	29244584
Hypersensitivity	118.35	15.56	198	29021	52705	29492603
Surgery	118.33	15.56	96	29123	11683	29533625
Acute kidney injury	115.81	15.56	59	29160	265208	29280100
Musculoskeletal disorder	114.95	15.56	69	29150	5171	29540137
Toxicity to various agents	111.16	15.56	19	29200	173642	29371666
Asthenia	110.18	15.56	462	28757	214788	29330520
Influenza	106.26	15.56	166	29053	41715	29503593
Cystitis	106.05	15.56	78	29141	8214	29537094
Neutropenia	97.34	15.56	9	29210	131702	29413606
Febrile neutropenia	97.26	15.56	3	29216	112237	29433071
Diarrhoea	92.66	15.56	116	29103	332582	29212726
Progressive multiple sclerosis	92.33	15.56	25	29194	209	29545099
Road traffic accident	91.68	15.56	94	29125	15467	29529841
Hypoaesthesia	90.11	15.56	177	29042	53290	29492018
Neoplasm malignant	88.60	15.56	96	29123	16829	29528479
Drug delivery device placement	85.69	15.56	21	29198	112	29545196
Nasopharyngitis	82.39	15.56	182	29037	59483	29485825
Drug ineffective	81.90	15.56	625	28594	362545	29182763
Neurogenic bladder	81.49	15.56	37	29182	1553	29543755
Anaemia	81.36	15.56	49	29170	200902	29344406
Multiple sclerosis	79.62	15.56	56	29163	5498	29539810
Primary progressive multiple sclerosis	77.53	15.56	16	29203	31	29545277
Visual impairment	72.90	15.56	116	29103	29592	29515716
Blood creatinine increased	71.19	15.56	3	29216	85099	29460209
Decreased appetite	68.43	15.56	29	29190	145313	29399995
Renal impairment	67.59	15.56	3	29216	81330	29463978
Coordination abnormal	65.22	15.56	55	29164	7059	29538249
Lower limb fracture	64.72	15.56	42	29177	3610	29541698
Infection	63.37	15.56	193	29026	76558	29468750
Dyspnoea	63.12	15.56	144	29075	326588	29218720
Neuromyelitis optica spectrum disorder	62.60	15.56	16	29203	104	29545204
Optic neuritis	58.17	15.56	37	29182	3072	29542236
Thrombocytopenia	57.19	15.56	31	29188	134792	29410516
Product use in unapproved indication	56.64	15.56	9	29210	86866	29458442
Depression	55.83	15.56	198	29021	84949	29460359
Urinary tract infection pseudomonal	55.43	15.56	22	29197	658	29544650
Haemoglobin decreased	53.65	15.56	20	29199	108355	29436953
Pancytopenia	53.36	15.56	9	29210	83159	29462149
Cellulitis	52.49	15.56	130	29089	45710	29499598
Hypotension	49.64	15.56	72	29147	194282	29351026
Condition aggravated	49.58	15.56	43	29176	146252	29399056
Hyponatraemia	48.92	15.56	5	29214	67628	29477680
Infusion site extravasation	48.27	15.56	33	29186	3094	29542214
Nausea	46.24	15.56	140	29079	289115	29256193
Drug abuse	44.40	15.56	12	29207	79871	29465437
Agraphia	44.11	15.56	9	29210	16	29545292
Cardiac failure	43.90	15.56	12	29207	79275	29466033
Nephrolithiasis	42.79	15.56	84	29135	25250	29520058
Rhabdomyolysis	42.70	15.56	5	29214	60803	29484505
Platelet count decreased	41.62	15.56	26	29193	104646	29440662
Hyperkalaemia	40.83	15.56	6	29213	61386	29483922
Somnolence	40.70	15.56	21	29198	93934	29451374
Gastrointestinal haemorrhage	40.50	15.56	14	29205	79519	29465789
Muscle spasms	39.80	15.56	148	29071	64934	29480374
Disease progression	39.07	15.56	16	29203	81900	29463408
JC virus granule cell neuronopathy	38.95	15.56	7	29212	3	29545305
No adverse event	37.15	15.56	64	29155	17414	29527894
White blood cell count decreased	37.06	15.56	18	29201	83344	29461964
Neutralising antibodies positive	36.99	15.56	10	29209	83	29545225
Intervertebral disc protrusion	36.59	15.56	44	29175	8626	29536682
Influenza like illness	36.42	15.56	77	29142	24393	29520915
Death	35.86	15.56	504	28715	341580	29203728
Foetal exposure timing unspecified	35.53	15.56	12	29207	224	29545084
Herpes zoster necrotising retinopathy	35.53	15.56	6	29213	0	29545308
Marburg's variant multiple sclerosis	35.53	15.56	6	29213	0	29545308
Prostate cancer	35.34	15.56	78	29141	25449	29519859
Trigeminal neuralgia	34.87	15.56	18	29201	1004	29544304
Abdominal pain	34.66	15.56	50	29169	135307	29410001
Epistaxis	34.50	15.56	5	29214	51699	29493609
Hip fracture	34.44	15.56	47	29172	10445	29534863
Weight increased	33.40	15.56	17	29202	76650	29468658
Renal failure	33.22	15.56	41	29178	118558	29426750
Malignant melanoma	32.97	15.56	38	29181	7123	29538185
Pleural effusion	31.24	15.56	16	29203	71892	29473416
Leukopenia	31.22	15.56	8	29211	55195	29490113
Chronic lymphocytic leukaemia	31.08	15.56	27	29192	3606	29541702
Escherichia urinary tract infection	31.00	15.56	25	29194	3014	29542294
Epilepsy	30.98	15.56	61	29158	18371	29526937
Staphylococcal infection	30.42	15.56	80	29139	29160	29516148
International normalised ratio increased	30.29	15.56	4	29215	44368	29500940
Mental disorder	29.74	15.56	49	29170	12856	29532452
Nutritional supplementation	29.61	15.56	5	29214	0	29545308
Neutrophil count decreased	29.57	15.56	4	29215	43563	29501745
Neuropathy peripheral	29.12	15.56	17	29202	71010	29474298
Cardiac failure congestive	29.10	15.56	20	29199	76561	29468747
Adverse reaction	28.67	15.56	23	29196	2752	29542556
Motor dysfunction	28.20	15.56	32	29187	5898	29539410
Product use issue	28.07	15.56	8	29211	51436	29493872
Testis cancer	27.97	15.56	15	29204	905	29544403
Peroneal nerve palsy	27.53	15.56	22	29197	2617	29542691
Metabolic acidosis	26.68	15.56	3	29216	37659	29507649
Decreased immune responsiveness	26.61	15.56	17	29202	1422	29543886
Upper respiratory tract infection	26.61	15.56	73	29146	27276	29518032
Stem cell transplant	26.10	15.56	19	29200	1968	29543340
Urinary incontinence	25.86	15.56	53	29166	16428	29528880
Drug hypersensitivity	25.81	15.56	18	29201	68388	29476920
Hemiparesis	25.64	15.56	49	29170	14437	29530871
Hypoglycaemia	25.50	15.56	8	29211	48338	29496970
Pneumonia aspiration	25.40	15.56	87	29132	36650	29508658
Relapsing-remitting multiple sclerosis	25.28	15.56	13	29206	719	29544589
Meningitis herpes	25.23	15.56	5	29214	7	29545301
Bipolar disorder	25.23	15.56	23	29196	3272	29542036
Multiple organ dysfunction syndrome	24.63	15.56	16	29203	63100	29482208
HIV test positive	24.60	15.56	8	29211	132	29545176
Glioblastoma	24.42	15.56	14	29205	962	29544346
Infected skin ulcer	24.38	15.56	16	29203	1401	29543907
CD8 lymphocytes decreased	24.30	15.56	7	29212	75	29545233
Appendicitis perforated	24.01	15.56	17	29202	1686	29543622
Antibody test positive	23.94	15.56	12	29207	629	29544679
C-reactive protein increased	23.93	15.56	7	29212	44256	29501052
Cardio-respiratory arrest	23.93	15.56	10	29209	50591	29494717
Haematochezia	23.71	15.56	4	29215	36979	29508329
Amnesia	23.60	15.56	62	29157	22581	29522727
Ascites	23.39	15.56	4	29215	36615	29508693
Chronic kidney disease	23.21	15.56	4	29215	36412	29508896
Hemianaesthesia	23.13	15.56	7	29212	90	29545218
Intentional overdose	22.93	15.56	5	29214	38523	29506785
Sinusitis	22.58	15.56	80	29139	34270	29511038
Central nervous system lymphoma	22.40	15.56	12	29207	722	29544586
Speech disorder	22.12	15.56	62	29157	23454	29521854
Ophthalmic herpes zoster	22.01	15.56	12	29207	748	29544560
Migraine	21.94	15.56	42	29177	12388	29532920
Vision blurred	21.80	15.56	88	29131	40088	29505220
Plasma cell myeloma	21.72	15.56	5	29214	37110	29508198
Mental impairment	21.46	15.56	35	29184	9106	29536202
Agitation	21.42	15.56	12	29207	51292	29494016
Tumefactive multiple sclerosis	21.38	15.56	5	29214	21	29545287
Tachycardia	21.37	15.56	24	29195	72386	29472922
Tremor	21.36	15.56	135	29084	73403	29471905
Paraparesis	21.22	15.56	16	29203	1748	29543560
Gallbladder operation	20.96	15.56	10	29209	470	29544838
Intervertebral disc operation	20.75	15.56	8	29211	221	29545087
Dysstasia	20.50	15.56	37	29182	10437	29534871
Aphasia	20.45	15.56	53	29166	19145	29526163
Bladder catheterisation	20.44	15.56	10	29209	497	29544811
Kidney infection	20.14	15.56	24	29195	4659	29540649
Peripheral swelling	20.07	15.56	20	29199	63719	29481589
Uhthoff's phenomenon	20.02	15.56	4	29215	6	29545302
Stomatitis	19.82	15.56	6	29213	37107	29508201
Temperature intolerance	19.70	15.56	19	29200	2902	29542406
Intentional product misuse	19.64	15.56	5	29214	34656	29510652
Oedema peripheral	19.60	15.56	46	29173	103511	29441797
Dysgraphia	19.18	15.56	16	29203	2022	29543286
Bradycardia	19.09	15.56	22	29197	65607	29479701
Arthropod bite	18.97	15.56	17	29202	2366	29542942
Overdose	18.96	15.56	31	29188	79788	29465520
Ill-defined disorder	18.85	15.56	38	29181	11640	29533668
B-cell lymphoma	18.83	15.56	21	29198	3797	29541511
Spinal operation	18.78	15.56	17	29202	2397	29542911
Lyme disease	18.68	15.56	11	29208	795	29544513
Herpes simplex encephalitis	18.53	15.56	8	29211	297	29545011
Bladder disorder	18.51	15.56	18	29201	2776	29542532
Hypoxia	18.50	15.56	12	29207	47367	29497941
Constipation	18.35	15.56	55	29164	114105	29431203
Myalgia	18.28	15.56	28	29191	73991	29471317
Depression suicidal	18.24	15.56	13	29206	1302	29544006
Vomiting	18.14	15.56	129	29090	212131	29333177
CD4 lymphocytes decreased	18.14	15.56	14	29205	1584	29543724
Headache	17.97	15.56	256	28963	173751	29371557
Osteomyelitis	17.97	15.56	41	29178	13668	29531640
Ataxia	17.91	15.56	38	29181	12065	29533243
Urinary tract disorder	17.84	15.56	15	29204	1917	29543391
Wernicke-Korsakoff syndrome	17.76	15.56	3	29216	0	29545308
Laryngeal cancer stage 0	17.76	15.56	3	29216	0	29545308
Drug rehabilitation	17.76	15.56	3	29216	0	29545308
Blood creatine phosphokinase increased	17.71	15.56	9	29210	40635	29504673
Bone marrow failure	17.52	15.56	3	29216	27446	29517862
Basal cell carcinoma	17.31	15.56	46	29173	16864	29528444
Vein disorder	17.21	15.56	11	29208	921	29544387
Concussion	17.09	15.56	15	29204	2031	29543277
Blindness	16.93	15.56	37	29182	11986	29533322
Lumbar radiculopathy	16.88	15.56	10	29209	731	29544577
Thrombocytopenia neonatal	16.87	15.56	8	29211	371	29544937
Immune system disorder	16.75	15.56	21	29198	4296	29541012
Stress	16.73	15.56	53	29166	21437	29523871
Hypokalaemia	16.68	15.56	15	29204	50188	29495120
Focal dyscognitive seizures	16.56	15.56	12	29207	1234	29544074
Joint swelling	16.29	15.56	15	29204	49615	29495693
Urticaria	16.28	15.56	101	29118	54559	29490749
Central venous catheterisation	16.15	15.56	11	29208	1025	29544283
Abdominal distension	16.13	15.56	13	29206	45898	29499410
Rectal haemorrhage	16.06	15.56	7	29212	34542	29510766
Blood urea increased	16.03	15.56	4	29215	28108	29517200
Injection site pain	16.01	15.56	6	29213	32440	29512868
Pneumonitis	15.98	15.56	4	29215	28040	29517268
Appendicectomy	15.97	15.56	10	29209	808	29544500
Rheumatoid arthritis	15.78	15.56	6	29213	32146	29513162
Hip arthroplasty	15.74	15.56	19	29200	3739	29541569
Head injury	15.71	15.56	43	29176	16038	29529270
Calculus bladder	15.70	15.56	10	29209	832	29544476
Back disorder	15.58	15.56	24	29195	5949	29539359

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	12377.70	13.23	3865	90081	37270	64367516
Progressive multifocal leukoencephalopathy	4735.35	13.23	1536	92410	16696	64388090
Immune reconstitution inflammatory syndrome	3043.73	13.23	1003	92943	11467	64393319
Urinary tract infection	1895.69	13.23	1991	91955	229605	64175181
General symptom	1391.14	13.23	371	93575	1857	64402929
Drug specific antibody present	987.50	13.23	346	93600	4808	64399978
Abortion spontaneous	953.77	13.23	541	93405	24602	64380184
Prescribed underdose	870.34	13.23	455	93491	17560	64387226
Malaise	793.78	13.23	1766	92180	394481	64010305
Fall	688.05	13.23	1723	92223	415103	63989683
Poor venous access	664.41	13.23	336	93610	12081	64392705
Balance disorder	564.89	13.23	653	93293	83273	64321513
Gait disturbance	523.84	13.23	916	93030	171239	64233547
Magnetic resonance imaging abnormal	464.79	13.23	174	93772	2949	64401837
Seizure	462.88	13.23	853	93093	166039	64238747
Maternal exposure during pregnancy	458.53	13.23	629	93317	95255	64309531
Secondary progressive multiple sclerosis	414.72	13.23	127	93819	1116	64403670
Off label use	411.31	13.23	205	93741	632601	63772185
Central nervous system lesion	406.65	13.23	239	93707	11610	64393176
Memory impairment	403.49	13.23	558	93388	85124	64319662
Drug interaction	396.05	13.23	36	93910	362047	64042739
Loss of control of legs	391.51	13.23	131	93815	1568	64403218
Herpes zoster	386.88	13.23	525	93421	78662	64326124
Toxicity to various agents	384.86	13.23	41	93905	363472	64041314
Muscle spasticity	362.19	13.23	252	93694	16417	64388369
Breast cancer	333.33	13.23	302	93644	28846	64375940
Muscular weakness	324.44	13.23	628	93318	126710	64278076
Hypersensitivity	321.50	13.23	811	93135	195641	64209145
Cognitive disorder	315.36	13.23	395	93551	54692	64350094
Acute kidney injury	293.75	13.23	144	93802	449096	63955690
JC polyomavirus test positive	285.62	13.23	96	93850	1166	64403620
Decubitus ulcer	273.78	13.23	195	93751	13184	64391602
Optic neuritis	271.39	13.23	161	93785	7955	64396831
Diarrhoea	260.19	13.23	408	93538	722296	63682490
Invasive ductal breast carcinoma	259.66	13.23	133	93813	4909	64399877
Caesarean section	258.01	13.23	176	93770	11098	64393688
Nasopharyngitis	256.04	13.23	745	93201	195328	64209458
Drug delivery device placement	250.81	13.23	58	93888	137	64404649
Febrile neutropenia	244.80	13.23	6	93940	187651	64217135
Influenza	239.68	13.23	499	93447	106032	64298754
Hypoaesthesia	236.54	13.23	583	93363	138525	64266261
Neutropenia	236.38	13.23	34	93912	239590	64165196
Cystitis	233.11	13.23	299	93647	42376	64362410
Gait inability	220.74	13.23	290	93656	42078	64362708
Road traffic accident	206.23	13.23	239	93707	30506	64374280
Musculoskeletal disorder	203.66	13.23	185	93761	17721	64387065
Urosepsis	197.72	13.23	200	93746	21894	64382892
Mobility decreased	196.46	13.23	405	93541	85435	64319351
Condition aggravated	195.36	13.23	154	93792	372272	64032514
Trigeminal neuralgia	189.62	13.23	92	93854	3017	64401769
Asthenia	182.11	13.23	1155	92791	426889	63977897
Surgery	182.03	13.23	215	93731	27998	64376788
Hysterectomy	172.96	13.23	102	93844	4983	64399803
Opportunistic infection	169.09	13.23	81	93865	2581	64402205
Visual impairment	168.90	13.23	349	93597	73728	64331058
Product use in unapproved indication	165.23	13.23	29	93917	176589	64228197
Progressive multiple sclerosis	162.31	13.23	56	93890	740	64404046
Neuromyelitis optica spectrum disorder	162.08	13.23	57	93889	800	64403986
Lower limb fracture	162.04	13.23	144	93802	13401	64391385
Neutralising antibodies positive	159.74	13.23	43	93903	224	64404562
Decreased appetite	159.54	13.23	107	93839	281182	64123604
Rheumatoid arthritis	151.47	13.23	28	93918	164266	64240520
Product use issue	150.77	13.23	21	93925	151694	64253092
Neurogenic bladder	148.35	13.23	82	93864	3537	64401249
Dyspnoea	144.80	13.23	549	93397	718125	63686661
Pancytopenia	142.02	13.23	20	93926	143289	64261497
Joint swelling	140.54	13.23	69	93877	215313	64189473
Drug hypersensitivity	135.44	13.23	90	93856	237725	64167061
Decreased immune responsiveness	135.19	13.23	83	93863	4365	64400421
Ankle fracture	134.99	13.23	135	93811	14575	64390211
Blood creatinine increased	134.43	13.23	19	93927	135763	64269023
Thrombocytopenia	133.92	13.23	80	93866	223721	64181065
Hip fracture	132.71	13.23	180	93766	26919	64377867
Malignant melanoma	132.10	13.23	126	93820	12838	64391948
Epilepsy	129.51	13.23	199	93747	33332	64371454
Drug abuse	127.65	13.23	20	93926	132354	64272432
Renal impairment	126.63	13.23	22	93924	134995	64269791
Hyperkalaemia	125.49	13.23	5	93941	101124	64303662
Stress	125.03	13.23	274	93672	60260	64344526
Injection site pain	124.53	13.23	10	93936	111398	64293388
Peripheral swelling	123.40	13.23	76	93870	209077	64195709
Hyponatraemia	123.13	13.23	32	93914	148307	64256479
Intervertebral disc protrusion	120.64	13.23	148	93798	20043	64384743
Contraindicated product administered	119.63	13.23	10	93936	107819	64296967
Depression	115.65	13.23	551	93395	182740	64222046
Multiple sclerosis	113.43	13.23	139	93807	18802	64385984
Hemiparesis	112.36	13.23	175	93771	29652	64375134
Anaemia	109.89	13.23	243	93703	378437	64026349
Platelet count decreased	108.97	13.23	54	93892	167657	64237129
Haemoglobin decreased	108.13	13.23	76	93870	194987	64209799
Vein disorder	106.04	13.23	69	93877	4018	64400768
Disease progression	105.93	13.23	37	93909	141643	64263143
Pregnancy	105.84	13.23	141	93805	20724	64384062
Intraductal proliferative breast lesion	105.74	13.23	55	93891	2096	64402690
Nephrolithiasis	105.69	13.23	211	93735	43472	64361314
Peroneal nerve palsy	105.28	13.23	76	93870	5245	64399541
Cardiac failure	103.48	13.23	32	93914	132341	64272445
Cervical dysplasia	103.42	13.23	52	93894	1844	64402942
Drug intolerance	103.21	13.23	74	93872	187918	64216868
Bronchitis	102.55	13.23	370	93576	108373	64296413
Upper respiratory tract infection	99.09	13.23	281	93665	72504	64332282
Hypotension	98.26	13.23	260	93686	380714	64024072
Coordination abnormal	98.11	13.23	115	93831	14849	64389937
Uterine leiomyoma	97.91	13.23	73	93873	5296	64399490
Muscle spasms	95.59	13.23	433	93513	140590	64264196
Electrocardiogram QT prolonged	95.08	13.23	5	93941	79443	64325343
Weight increased	94.24	13.23	103	93843	213245	64191541
Herpes zoster necrotising retinopathy	94.07	13.23	17	93929	0	64404786
Migraine	93.28	13.23	250	93696	62427	64342359
Therapeutic product effect incomplete	92.47	13.23	19	93927	103463	64301323
Abdominal pain	90.95	13.23	200	93746	312175	64092611
Stomatitis	90.27	13.23	24	93922	109581	64295205
Infusion site extravasation	88.44	13.23	76	93870	6761	64398025
Rhabdomyolysis	85.88	13.23	15	93931	91711	64313075
Breech presentation	85.44	13.23	33	93913	611	64404175
Gastrointestinal haemorrhage	85.34	13.23	43	93903	132269	64272517
Injection site erythema	83.04	13.23	5	93941	70795	64333991
Mental impairment	82.21	13.23	110	93836	16233	64388553
Multiple organ dysfunction syndrome	82.02	13.23	23	93923	101390	64303396
Leukopenia	81.81	13.23	23	93923	101219	64303567
C-reactive protein increased	81.61	13.23	19	93927	94890	64309896
Intentional overdose	81.44	13.23	16	93930	89928	64314858
Staphylococcal infection	81.39	13.23	208	93738	50470	64354316
Sinusitis	80.89	13.23	423	93523	145505	64259281
Kidney infection	80.61	13.23	114	93832	17724	64387062
JC virus granule cell neuronopathy	80.43	13.23	22	93924	123	64404663
Nausea	79.23	13.23	748	93198	785052	63619734
Prolonged labour	78.59	13.23	28	93918	409	64404377
Glossodynia	77.64	13.23	4	93942	64692	64340094
Gallbladder operation	76.45	13.23	41	93905	1664	64403122
Escherichia urinary tract infection	76.42	13.23	91	93855	11946	64392840
Pleural effusion	75.99	13.23	45	93901	126514	64278272
Interstitial lung disease	75.70	13.23	24	93922	97708	64307078
Hospitalisation	75.66	13.23	10	93936	75197	64329589
Arthralgia	74.55	13.23	361	93585	441899	63962887
Urinary tract infection pseudomonal	74.34	13.23	38	93908	1396	64403390
Urticaria	74.19	13.23	416	93530	146901	64257885
Epistaxis	72.70	13.23	26	93920	98105	64306681
White blood cell count decreased	72.14	13.23	74	93872	157763	64247023
International normalised ratio increased	71.85	13.23	14	93932	79153	64325633
Intentional product misuse	71.81	13.23	10	93936	72285	64332501
Urinary incontinence	71.66	13.23	161	93785	35990	64368796
Dyspnoea exertional	71.38	13.23	11	93935	73719	64331067
Relapsing-remitting multiple sclerosis	71.24	13.23	34	93912	1074	64403712
Central venous catheterisation	70.44	13.23	46	93900	2695	64402091
Anaphylactic shock	70.39	13.23	144	93802	30184	64374602
Aphasia	69.99	13.23	172	93774	40734	64364052
Wrong technique in product usage process	69.45	13.23	7	93939	64967	64339819
Neutrophil count decreased	69.33	13.23	14	93932	77182	64327604
Completed suicide	69.20	13.23	139	93807	224275	64180511
Atrial fibrillation	68.70	13.23	89	93857	171000	64233786
Renal failure	68.44	13.23	99	93847	181589	64223197
Cellulitis	68.30	13.23	294	93652	93363	64311423
Diplopia	68.02	13.23	132	93814	26633	64378153
Headache	67.89	13.23	1115	92831	528352	63876434
Gastroenteritis viral	67.77	13.23	111	93835	19618	64385168
Neuropathy peripheral	67.49	13.23	44	93902	117481	64287305
Gastric bypass	66.84	13.23	32	93914	1018	64403768
Head injury	65.92	13.23	147	93799	32695	64372091
Post lumbar puncture syndrome	65.82	13.23	28	93918	671	64404115
Bladder disorder	65.29	13.23	68	93878	7699	64397087
Lactic acidosis	64.65	13.23	7	93939	61403	64343383
Abdominal discomfort	64.21	13.23	104	93842	182218	64222568
Treatment failure	64.06	13.23	46	93900	116770	64288016
Infection	63.52	13.23	474	93472	184406	64220380
Thyroid cancer	63.42	13.23	50	93896	3941	64400845
Drug reaction with eosinophilia and systemic symptoms	63.07	13.23	4	93942	54213	64350573
Somnolence	62.90	13.23	126	93820	203519	64201267
Focal dyscognitive seizures	62.84	13.23	46	93900	3244	64401542
Hypoxia	62.55	13.23	25	93921	88124	64316662
Cardio-respiratory arrest	61.92	13.23	33	93913	98360	64306426
Metabolic acidosis	61.41	13.23	14	93932	70944	64333842
Hypoglycaemia	61.36	13.23	27	93919	89865	64314921
Speech disorder	61.08	13.23	182	93764	48259	64356527
Ascites	60.59	13.23	9	93937	61992	64342794
Cholecystectomy	59.90	13.23	66	93880	7966	64396820
Upper limb fracture	59.90	13.23	90	93856	14776	64390010
Appendicitis perforated	59.76	13.23	42	93904	2778	64402008
Mental disorder	59.53	13.23	124	93822	26321	64378465
Vision blurred	59.44	13.23	275	93671	90041	64314745
Loss of personal independence in daily activities	59.39	13.23	16	93930	72438	64332348
Melaena	59.29	13.23	5	93941	53543	64351243
Oxygen saturation decreased	59.04	13.23	42	93904	107134	64297652
Meningitis herpes	58.98	13.23	19	93927	200	64404586
Incorrect dose administered	58.97	13.23	9	93937	60756	64344030
Central nervous system lymphoma	58.53	13.23	36	93910	1899	64402887
Papillary thyroid cancer	57.67	13.23	38	93908	2260	64402526
Pharyngitis streptococcal	57.46	13.23	67	93879	8601	64396185
Breast cancer stage I	57.11	13.23	34	93912	1690	64403096
Rash maculo-papular	56.13	13.23	3	93943	47023	64357763
Chronic lymphocytic leukaemia	55.88	13.23	48	93898	4267	64400519
Foot fracture	55.53	13.23	97	93849	18060	64386726
Primary progressive multiple sclerosis	55.43	13.23	15	93931	80	64404706
Uhthoff's phenomenon	55.33	13.23	10	93936	0	64404786
Cervix carcinoma	54.93	13.23	34	93912	1814	64402972
Ectopic pregnancy	54.84	13.23	32	93914	1532	64403254
Bradycardia	54.50	13.23	55	93891	118164	64286622
Breast cancer in situ	53.77	13.23	26	93920	846	64403940
Cardiac failure congestive	53.37	13.23	67	93879	130513	64274273
Endometriosis	53.24	13.23	39	93907	2753	64402033
Tachycardia	52.96	13.23	85	93861	149494	64255292
Amnesia	52.24	13.23	172	93774	48097	64356689
No adverse event	51.98	13.23	123	93823	28438	64376348
Adverse reaction	51.93	13.23	60	93886	7627	64397159
Cough	51.79	13.23	245	93701	301903	64102883
Bipolar disorder	51.19	13.23	56	93890	6705	64398081
Vomiting	51.04	13.23	535	93411	550582	63854204
Partial seizures	51.00	13.23	58	93888	7249	64397537
Myalgia	50.82	13.23	96	93850	158521	64246265
Alopecia	50.74	13.23	103	93843	165587	64239199
Influenza like illness	49.92	13.23	200	93746	61502	64343284
Intentional product use issue	49.16	13.23	40	93906	95324	64309462
Invasive lobular breast carcinoma	48.58	13.23	21	93925	524	64404262
Blood creatine phosphokinase increased	47.87	13.23	13	93933	58545	64346241
Therapeutic response decreased	47.84	13.23	9	93937	52179	64352607
Dysgraphia	47.80	13.23	40	93906	3431	64401355
Breast cancer female	47.12	13.23	47	93899	5056	64399730
Adverse drug reaction	46.54	13.23	159	93787	45305	64359481
Tibia fracture	46.23	13.23	45	93901	4700	64400086
Lower respiratory tract infection	44.78	13.23	43	93903	94571	64310215
Swelling	44.60	13.23	105	93841	160113	64244673
Bone marrow failure	44.53	13.23	8	93938	47944	64356842
Fatigue	44.38	13.23	1414	92532	747316	63657470
Lymphocytosis	44.10	13.23	39	93907	3605	64401181
Meningioma	43.92	13.23	40	93906	3842	64400944
Temperature intolerance	43.74	13.23	57	93889	8198	64396588
Psoriasis	43.73	13.23	25	93921	71678	64333108
Therapy non-responder	43.10	13.23	21	93925	65878	64338908
Rectal haemorrhage	43.09	13.23	18	93928	61799	64342987
Injection site reaction	42.87	13.23	8	93938	46656	64358130
Productive cough	42.57	13.23	27	93919	73176	64331610
Pericarditis	42.31	13.23	19	93927	62497	64342289
Dyspepsia	42.26	13.23	33	93913	80279	64324507
Exposure during pregnancy	42.04	13.23	31	93915	77644	64327142
Systemic lupus erythematosus	41.97	13.23	31	93915	77581	64327205
Foetal malposition	41.77	13.23	9	93937	13	64404773
Rash	41.66	13.23	447	93499	458102	63946684
Injection site bruising	41.38	13.23	3	93943	36370	64368416
Adenocarcinoma of colon	41.31	13.23	43	93903	4865	64399921
Dysstasia	41.19	13.23	99	93847	23116	64381670
Agranulocytosis	41.16	13.23	4	93942	38225	64366561
Medication error	41.01	13.23	11	93935	49955	64354831
Tremor	40.59	13.23	361	93585	147869	64256917
Abdominal distension	40.55	13.23	48	93898	95946	64308840
Blood pressure systolic increased	40.38	13.23	11	93935	49442	64355344
Viral infection	40.20	13.23	130	93816	36010	64368776
Basal cell carcinoma	39.96	13.23	117	93829	30721	64374065
Haemoptysis	39.88	13.23	11	93935	49037	64355749
Unevaluable event	39.81	13.23	12	93934	50477	64354309
White blood cell count increased	39.79	13.23	196	93750	65818	64338968
Blood urea increased	39.65	13.23	8	93938	44145	64360641
Oedema peripheral	39.35	13.23	165	93781	210152	64194634
Fibula fracture	39.28	13.23	34	93912	3054	64401732
Herpes simplex encephalitis	39.18	13.23	19	93927	622	64404164
Cardiac arrest	38.98	13.23	106	93840	153958	64250828
Pruritus allergic	38.74	13.23	21	93925	871	64403915
Marburg's variant multiple sclerosis	38.73	13.23	7	93939	0	64404786
Overdose	38.73	13.23	112	93834	159454	64245332
Abortion missed	38.53	13.23	23	93923	1149	64403637
Ophthalmic herpes zoster	38.28	13.23	29	93917	2155	64402631
Flushing	38.18	13.23	220	93726	78428	64326358
Clostridial infection	38.07	13.23	42	93904	5077	64399709
Concussion	37.75	13.23	52	93894	7886	64396900
Serotonin syndrome	37.70	13.23	6	93940	39276	64365510
Agitation	37.52	13.23	44	93902	88323	64316463
Hypokalaemia	37.12	13.23	76	93870	121827	64282959
Chronic kidney disease	37.06	13.23	19	93927	57900	64346886
Blister	36.93	13.23	38	93908	80929	64323857
Appendicectomy	36.32	13.23	28	93918	2135	64402651
Urostomy	36.24	13.23	7	93939	3	64404783
Osteonecrosis of jaw	36.22	13.23	7	93939	39818	64364968
Antibody test positive	35.78	13.23	29	93917	2378	64402408
Drug level increased	35.73	13.23	4	93942	34192	64370594
Pyelonephritis	35.45	13.23	78	93868	17188	64387598
Agraphia	35.37	13.23	9	93937	36	64404750
Ovarian cancer	35.22	13.23	33	93913	3286	64401500
Skin exfoliation	34.79	13.23	11	93935	44874	64359912
Constipation	34.73	13.23	194	93752	229143	64175643
Oedema	34.69	13.23	50	93896	91885	64312901
Sensory disturbance	34.61	13.23	66	93880	13142	64391644
Pneumonitis	34.57	13.23	15	93931	50350	64354436
Helicobacter infection	34.35	13.23	7	93939	38355	64366431
Hypervolaemia	34.25	13.23	7	93939	38278	64366508
Haematochezia	34.01	13.23	28	93918	66345	64338441
Hepatocellular injury	33.47	13.23	12	93934	45223	64359563
Arthropathy	33.08	13.23	80	93866	120887	64283899
Weight decreased	33.07	13.23	262	93684	285477	64119309
Cholestasis	33.03	13.23	12	93934	44860	64359926
Depression suicidal	33.01	13.23	28	93918	2447	64402339
Post procedural infection	32.97	13.23	54	93892	9543	64395243
Haematuria	32.90	13.23	24	93922	60447	64344339
Plasma cell myeloma	32.79	13.23	13	93933	46062	64358724
Hypocalcaemia	32.78	13.23	10	93936	41743	64363043
Band sensation	32.58	13.23	17	93929	652	64404134
Meningitis viral	32.52	13.23	24	93922	1714	64403072
Hyperhidrosis	32.31	13.23	85	93861	124835	64279951
Sopor	32.21	13.23	3	93943	29658	64375128
Hemianaesthesia	32.14	13.23	15	93931	450	64404336
Inappropriate schedule of product administration	32.13	13.23	53	93893	92233	64312553
Delirium	32.10	13.23	32	93914	69162	64335624
Hepatic function abnormal	31.89	13.23	28	93918	64285	64340501
Female genital operation	31.76	13.23	7	93939	12	64404774
Malignant melanoma in situ	31.53	13.23	24	93922	1796	64402990
Lung adenocarcinoma	31.36	13.23	44	93902	6789	64397997
Tubulointerstitial nephritis	31.35	13.23	4	93942	30905	64373881
Ventricular tachycardia	31.21	13.23	6	93940	34259	64370527
Depressed level of consciousness	31.01	13.23	44	93902	81392	64323394
Dry skin	30.96	13.23	18	93928	51143	64353643
Pneumonia aspiration	30.89	13.23	169	93777	59102	64345684
Immune system disorder	30.81	13.23	51	93895	9090	64395696
JC polyomavirus test	30.50	13.23	8	93938	37	64404749
Generalised tonic-clonic seizure	30.50	13.23	127	93819	39730	64365056
Arthropod bite	30.43	13.23	43	93903	6678	64398108
Shock	30.31	13.23	9	93937	38231	64366555
Drug resistance	30.22	13.23	7	93939	35095	64369691
Hyperglycaemia	29.68	13.23	27	93919	60941	64343845
Steroid therapy	29.51	13.23	8	93938	43	64404743
Red blood cell sedimentation rate increased	29.46	13.23	5	93941	31230	64373556
B-cell lymphoma	29.41	13.23	38	93908	5419	64399367
Wheezing	29.26	13.23	45	93901	80534	64324252
Bladder dysfunction	28.88	13.23	18	93928	972	64403814
Incontinence	28.78	13.23	58	93888	12023	64392763
Motor dysfunction	28.78	13.23	56	93890	11317	64393469
Restlessness	28.68	13.23	11	93935	39774	64365012
Neutralising antibodies	28.58	13.23	7	93939	23	64404763
Circulatory collapse	28.50	13.23	7	93939	33725	64371061
Partial seizures with secondary generalisation	28.33	13.23	14	93932	478	64404308
Coagulopathy	28.22	13.23	6	93940	31914	64372872
Arrested labour	28.20	13.23	10	93936	144	64404642
Meningoencephalitis herpetic	27.85	13.23	22	93924	1739	64403047
Feeling hot	27.82	13.23	136	93810	45527	64359259
Animal bite	27.73	13.23	24	93922	2155	64402631
Vaginal infection	27.68	13.23	35	93911	4885	64399901
Hypertension	27.60	13.23	243	93703	259018	64145768
Appendicitis	27.52	13.23	61	93885	13508	64391278
Hypomagnesaemia	27.51	13.23	10	93936	37366	64367420
Orthostatic hypotension	27.50	13.23	17	93929	46721	64358065
Sedation	27.44	13.23	13	93933	41449	64363337
Bladder catheterisation	27.40	13.23	16	93930	767	64404019
Neurogenic bowel	27.29	13.23	10	93936	159	64404627
Inflammation	27.20	13.23	33	93913	65267	64339519
Mammoplasty	27.20	13.23	11	93935	231	64404555
Anal incontinence	27.17	13.23	65	93881	15131	64389655
Proteinuria	27.14	13.23	4	93942	27719	64377067
Urinary tract disorder	27.12	13.23	28	93918	3138	64401648
Disseminated intravascular coagulation	26.78	13.23	7	93939	32341	64372445
Treatment noncompliance	26.74	13.23	15	93931	43467	64361319
Blood pressure fluctuation	26.43	13.23	22	93924	51849	64352937
Postoperative wound infection	26.29	13.23	51	93895	10285	64394501
Conversion disorder	26.17	13.23	21	93925	1698	64403088
Ear infection	25.86	13.23	84	93862	23320	64381466
Tachypnoea	25.63	13.23	4	93942	26567	64378219
Major depression	25.54	13.23	43	93903	7773	64397013
Haematemesis	25.12	13.23	19	93927	46980	64357806
Nasal congestion	25.01	13.23	30	93916	59628	64345158
Umbilical cord around neck	24.91	13.23	6	93940	18	64404768
Pneumocystis jirovecii pneumonia	24.83	13.23	5	93941	27629	64377157
Urinary tract infection staphylococcal	24.77	13.23	15	93931	769	64404017
Glioblastoma	24.73	13.23	19	93927	1442	64403344
Papilloma viral infection	24.69	13.23	19	93927	1445	64403341
Dry mouth	24.68	13.23	31	93915	60387	64344399
Cervix carcinoma stage III	24.66	13.23	6	93940	19	64404767
Haemorrhage	24.55	13.23	49	93897	79302	64325484
Thermal burn	24.14	13.23	36	93910	5870	64398916
Disease recurrence	23.93	13.23	8	93938	31502	64373284
Infectious mononucleosis	23.92	13.23	20	93926	1713	64403073
Flatulence	23.88	13.23	11	93935	35655	64369131
General physical health deterioration	23.84	13.23	187	93759	204238	64200548
Intrathecal pump insertion	23.73	13.23	5	93941	6	64404780
Incorrect route of product administration	23.66	13.23	3	93943	23295	64381491
Pulmonary hypertension	23.62	13.23	17	93929	43122	64361664
Obstructive airways disorder	23.51	13.23	3	93943	23182	64381604
Septic shock	23.45	13.23	77	93869	105360	64299426
Upper gastrointestinal haemorrhage	23.37	13.23	11	93935	35209	64369577
Infected skin ulcer	23.12	13.23	25	93921	2955	64401831
Medical device removal	23.11	13.23	13	93933	580	64404206
Paraparesis	23.10	13.23	27	93919	3475	64401311
Rebound effect	23.07	13.23	32	93914	4885	64399901
Bile acid malabsorption	23.04	13.23	9	93937	172	64404614
Vertigo	22.96	13.23	156	93790	58855	64345931
Myelitis transverse	22.96	13.23	19	93927	1604	64403182
Fluid retention	22.90	13.23	32	93914	59574	64345212
Ligament rupture	22.76	13.23	23	93923	2513	64402273
Palpitations	22.76	13.23	77	93869	104411	64300375
Blood potassium increased	22.73	13.23	5	93941	25975	64378811
Medical device change	22.67	13.23	12	93934	474	64404312
Faeces discoloured	22.41	13.23	5	93941	25724	64379062
Status epilepticus	22.37	13.23	76	93870	21587	64383199
Catheter placement	22.33	13.23	23	93923	2570	64402216
Pulmonary oedema	22.33	13.23	51	93895	78623	64326163
Ejection fraction decreased	22.31	13.23	7	93939	28700	64376086
Hypercalcaemia	22.13	13.23	9	93937	31407	64373379
Colon cancer metastatic	22.12	13.23	20	93926	1903	64402883
Paraesthesia	22.11	13.23	296	93650	134226	64270560
Gastrooesophageal reflux disease	21.93	13.23	56	93890	83087	64321699
Knee operation	21.89	13.23	30	93916	4527	64400259
Progressive relapsing multiple sclerosis	21.87	13.23	6	93940	34	64404752
Drug ineffective for unapproved indication	21.80	13.23	9	93937	31124	64373662
Poisoning	21.78	13.23	3	93943	21876	64382910
Frustration tolerance decreased	21.77	13.23	35	93911	6090	64398696
Ovarian mass	21.70	13.23	11	93935	397	64404389
Tumefactive multiple sclerosis	21.62	13.23	7	93939	75	64404711
Respiratory depression	21.57	13.23	4	93942	23439	64381347
Ataxia	21.52	13.23	76	93870	22008	64382778
Blood pressure increased	21.46	13.23	155	93791	172397	64232389
Goitre	21.32	13.23	31	93915	4942	64399844
Cervical spinal stenosis	21.20	13.23	20	93926	2009	64402777
H1N1 influenza	21.16	13.23	21	93925	2245	64402541
Calculus bladder	20.94	13.23	16	93930	1204	64403582
Blood lactate dehydrogenase increased	20.94	13.23	11	93935	33067	64371719
Cephalo-pelvic disproportion	20.87	13.23	8	93938	145	64404641
Oral pain	20.84	13.23	7	93939	27486	64377300
Cellulitis staphylococcal	20.82	13.23	15	93931	1032	64403754
Spondylitic myelopathy	20.78	13.23	6	93940	42	64404744
Foetal heart rate deceleration abnormality	20.75	13.23	7	93939	86	64404700
Angina pectoris	20.73	13.23	21	93925	45060	64359726
Infusion site haematoma	20.66	13.23	9	93937	229	64404557
Red blood cell count decreased	20.64	13.23	24	93922	48362	64356424
Therapeutic procedure	20.50	13.23	13	93933	724	64404062
Tooth infection	20.47	13.23	57	93889	14544	64390242
Multiple allergies	20.36	13.23	33	93913	5781	64399005
Colon cancer	20.15	13.23	52	93894	12687	64392099
Sleep disorder	20.13	13.23	35	93911	59674	64345112
Blood pressure diastolic decreased	20.11	13.23	4	93942	22297	64382489
Endometrial adenocarcinoma	20.03	13.23	14	93932	918	64403868
Herpes simplex meningitis	19.98	13.23	6	93940	49	64404737
Blindness	19.95	13.23	74	93872	21945	64382841
B-cell lymphoma stage I	19.90	13.23	4	93942	3	64404783
Ependymoma	19.77	13.23	6	93940	51	64404735
Drug dependence	19.76	13.23	12	93934	33300	64371486
Prescribed overdose	19.75	13.23	3	93943	20328	64384458
Fibroadenoma of breast	19.66	13.23	9	93937	258	64404528
Bladder repair	19.66	13.23	6	93940	52	64404734
Hip surgery	19.63	13.23	21	93925	2452	64402334
Procedural pain	19.29	13.23	58	93888	15450	64389336
Muscle tightness	19.29	13.23	47	93899	11068	64393718
Hyperemesis gravidarum	19.27	13.23	10	93936	379	64404407
Red blood cell nucleated morphology present	19.27	13.23	5	93941	22	64404764
Autoimmune hepatitis	18.97	13.23	44	93902	10040	64394746
Mouth ulceration	18.82	13.23	12	93934	32432	64372354
Plasmablastic lymphoma	18.80	13.23	10	93936	399	64404387
Post procedural complication	18.72	13.23	71	93875	21282	64383504
Pelvic fracture	18.69	13.23	45	93901	10518	64394268
Jaundice	18.68	13.23	26	93920	48486	64356300
Squamous cell carcinoma of the cervix	18.57	13.23	8	93938	198	64404588
Pericardial effusion	18.38	13.23	18	93928	39236	64365550
Mammogram abnormal	18.29	13.23	10	93936	422	64404364
Gastrointestinal viral infection	18.24	13.23	14	93932	1061	64403725
Ventricular fibrillation	18.22	13.23	6	93940	23854	64380932
Back injury	18.19	13.23	37	93909	7720	64397066
CD4 lymphocytes decreased	18.14	13.23	20	93926	2415	64402371
Osteomyelitis	18.13	13.23	84	93862	27503	64377283
Respiratory failure	18.07	13.23	149	93797	161034	64243752
Intervertebral disc operation	18.03	13.23	12	93934	726	64404060
Cardiomegaly	18.01	13.23	6	93940	23678	64381108
Rash erythematous	17.80	13.23	27	93919	48606	64356180
Withdrawal syndrome	17.78	13.23	6	93940	23486	64381300
Latent tuberculosis	17.76	13.23	21	93925	2736	64402050
Herpes zoster meningitis	17.67	13.23	7	93939	139	64404647
Human papilloma virus test positive	17.60	13.23	10	93936	455	64404331
Aggression	17.58	13.23	25	93921	46207	64358579
Lung adenocarcinoma stage IV	17.52	13.23	8	93938	228	64404558
Spinal fusion surgery	17.49	13.23	24	93922	3627	64401159
Bladder operation	17.48	13.23	12	93934	764	64404022
Pulmonary fibrosis	17.40	13.23	11	93935	29867	64374919
Respiratory distress	17.34	13.23	31	93915	52300	64352486
Hepatic failure	17.31	13.23	34	93912	55360	64349426
Herpes zoster infection neurological	17.27	13.23	7	93939	148	64404638
Dysphemia	17.25	13.23	22	93924	3097	64401689
Blood alkaline phosphatase increased	17.20	13.23	35	93911	56244	64348542
Heat exhaustion	17.14	13.23	8	93938	240	64404546
Infusion site hypersensitivity	17.14	13.23	4	93942	10	64404776
Abdominoplasty	17.08	13.23	5	93941	37	64404749
Precancerous cells present	16.90	13.23	13	93933	988	64403798
Imminent abortion	16.86	13.23	4	93942	11	64404775
Blindness unilateral	16.76	13.23	33	93913	6728	64398058
Gastric banding	16.74	13.23	5	93941	40	64404746
Transfusion	16.71	13.23	3	93943	17991	64386795
Urethral valves	16.60	13.23	3	93943	0	64404786
Alcoholic seizure	16.60	13.23	3	93943	0	64404786
Intracranial haemangioma	16.60	13.23	3	93943	0	64404786
Gestational oedema	16.60	13.23	3	93943	0	64404786
Magnetic resonance imaging head abnormal	16.59	13.23	19	93927	2393	64402393
Endometrial cancer	16.55	13.23	17	93929	1893	64402893
Abortion	16.52	13.23	14	93932	1222	64403564
Respiratory tract infection	16.46	13.23	102	93844	37305	64367481
Neurological symptom	16.41	13.23	33	93913	6831	64397955
Cholelithiasis	16.36	13.23	118	93828	45388	64359398
Hypoalbuminaemia	16.30	13.23	3	93943	17671	64387115
Folliculitis	16.28	13.23	12	93934	30065	64374721
HIV test positive	16.23	13.23	6	93940	98	64404688
Female reproductive tract disorder	16.22	13.23	8	93938	272	64404514
Acute myocardial infarction	16.14	13.23	50	93896	69668	64335118
Rhinorrhoea	16.12	13.23	40	93906	59929	64344857
Arrhythmia	16.12	13.23	33	93913	52911	64351875
Fibromyalgia	16.03	13.23	17	93929	35714	64369072
Back disorder	16.03	13.23	41	93905	9949	64394837
Face oedema	16.02	13.23	8	93938	24753	64380033
Wound sepsis	15.96	13.23	7	93939	181	64404605
Product administered to patient of inappropriate age	15.95	13.23	26	93920	4575	64400211
Ligament sprain	15.84	13.23	43	93903	10809	64393977
Breast cyst	15.81	13.23	13	93933	1088	64403698
Hepatotoxicity	15.81	13.23	21	93925	39941	64364845
Pineal gland cyst	15.72	13.23	4	93942	16	64404770
Lung cancer metastatic	15.58	13.23	21	93925	3119	64401667
Dysgeusia	15.48	13.23	28	93918	47019	64357767
Patella fracture	15.44	13.23	15	93931	1563	64403223
Leukocytosis	15.42	13.23	101	93845	37639	64367147
Dysarthria	15.39	13.23	143	93803	59263	64345523
Glioblastoma multiforme	15.37	13.23	13	93933	1131	64403655
Drug eruption	15.33	13.23	18	93928	36118	64368668
Demyelination	15.33	13.23	32	93914	6802	64397984
Melanocytic naevus	15.27	13.23	24	93922	4096	64400690
Pneumonia	15.26	13.23	977	92969	558599	63846187
Foetal distress syndrome	15.20	13.23	9	93937	443	64404343
Dry eye	15.16	13.23	12	93934	29007	64375779
Myelitis	15.13	13.23	17	93929	2097	64402689
Feeling abnormal	15.09	13.23	276	93670	133326	64271460
Osteonecrosis	15.05	13.23	81	93865	28148	64376638
Cardiogenic shock	15.03	13.23	15	93931	32412	64372374
Vitamin D decreased	14.97	13.23	34	93912	7653	64397133
Tenderness	14.84	13.23	5	93941	19597	64385189
Neurofibroma	14.83	13.23	4	93942	21	64404765
Cerebral infarction	14.82	13.23	23	93923	41021	64363765
Expanded disability status scale score increased	14.80	13.23	9	93937	465	64404321
Urine output decreased	14.78	13.23	3	93943	16489	64388297
Vaccination complication	14.78	13.23	10	93936	622	64404164
Foetal heart rate decreased	14.68	13.23	4	93942	22	64404764
Panic attack	14.67	13.23	65	93881	20888	64383898
Nodule	14.64	13.23	4	93942	17943	64386843
Pertussis	14.61	13.23	11	93935	810	64403976
Cerebral haemorrhage	14.59	13.23	33	93913	51057	64353729
Pain in jaw	14.56	13.23	23	93923	40732	64364054
JC virus infection	14.51	13.23	21	93925	3334	64401452
Blepharospasm	14.41	13.23	21	93925	3354	64401432
Ileostomy closure	14.33	13.23	6	93940	138	64404648
Myocardial ischaemia	14.33	13.23	8	93938	23243	64381543
Device malfunction	14.25	13.23	4	93942	17629	64387157
Abdominal pain upper	14.13	13.23	175	93771	174855	64229931
Vibratory sense increased	14.11	13.23	4	93942	26	64404760
Micturition urgency	14.09	13.23	40	93906	10319	64394467
Lumbar radiculopathy	14.09	13.23	15	93931	1742	64403044
Device extrusion	13.98	13.23	4	93942	27	64404759
Astrocytoma malignant	13.98	13.23	4	93942	27	64404759
Oral infection	13.93	13.23	25	93921	4752	64400034
Sinus bradycardia	13.93	13.23	8	93938	22885	64381901
Foetal heart rate abnormal	13.90	13.23	7	93939	249	64404537
Blindness transient	13.90	13.23	23	93923	4099	64400687
Skull fracture	13.87	13.23	14	93932	1527	64403259
Lumbar puncture	13.80	13.23	6	93940	152	64404634
Automatic bladder	13.79	13.23	5	93941	77	64404709
Platelet count increased	13.76	13.23	5	93941	18691	64386095
Gout	13.73	13.23	7	93939	21406	64383380
Metabolic surgery	13.72	13.23	11	93935	888	64403898
Anembryonic gestation	13.71	13.23	8	93938	383	64404403
Sinus tachycardia	13.69	13.23	16	93930	32172	64372614
Colectomy	13.66	13.23	18	93928	2616	64402170
Haemorrhage intracranial	13.62	13.23	9	93937	23875	64380911
Benign neoplasm	13.58	13.23	11	93935	901	64403885
Haematocrit decreased	13.52	13.23	38	93908	54617	64350169
Ovarian cyst	13.51	13.23	41	93905	10977	64393809
Hyperbilirubinaemia	13.50	13.23	7	93939	21198	64383588
Eczema	13.49	13.23	14	93932	29706	64375080
Nerve compression	13.43	13.23	32	93914	7429	64397357
Clumsiness	13.36	13.23	18	93928	2673	64402113
Diplegia	13.35	13.23	14	93932	1597	64403189
Blood albumin decreased	13.35	13.23	7	93939	21066	64383720
Breast reconstruction	13.34	13.23	5	93941	85	64404701
Gastrointestinal procedural complication	13.34	13.23	5	93941	85	64404701
Abdominal adhesions	13.34	13.23	19	93927	2973	64401813
Frequent bowel movements	13.30	13.23	5	93941	18300	64386486
Ovarian cystectomy	13.28	13.23	5	93941	86	64404700
Drowning	13.25	13.23	10	93936	739	64404047

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L04AA23	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Selective immunosuppressants
MeSH PA	D007155	Immunologic Factors
FDA MoA	N0000175774	Integrin Receptor Antagonists
FDA EPC	N0000175775	Integrin Receptor Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Multiple sclerosis	indication	24700007	DOID:2377
Crohn's disease	indication	34000006
Progressive multifocal leukoencephalopathy	contraindication	22255007	DOID:643

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Integrin alpha-4/beta-1	Adhesion	P13612 P05556	ITA4_HUMAN ITB1_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL
Integrin alpha-4/beta-7	Adhesion	P13612 P26010	ITA4_HUMAN ITB7_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D06886	KEGG_DRUG
4021508	VUID
N0000148870	NUI
4021508	VANDF
CHEMBL1201607	ChEMBL_ID
6591	IUPHAR_LIGAND_ID
7716	INN_ID
DB00108	DRUGBANK_ID
3JB47N2Q2P	UNII
354770	RXNORM
19083	MMSL
63826	MMSL
d05414	MMSL
414804006	SNOMEDCT_US
414805007	SNOMEDCT_US
D000069442	MESH_DESCRIPTOR_UI
C1172734	UMLSCUI
008765	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TYSABRI	HUMAN PRESCRIPTION DRUG LABEL	1	64406-008	INJECTION	300 mg	INTRAVENOUS	BLA	30 sections