natalizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4970 189261-10-7

Description:

MoleculeDescription

Synonyms:

  • antegren
  • natalizumab
  • tysabri
A humanized monoclonal immunoglobulin G4 antibody to human INTEGRIN ALPHA4 that binds to the alpha4 subunit of INTEGRIN ALPHA4BETA1 and integrin alpha4beta7. It is used as an IMMUNOLOGIC FACTOR in the treatment of RELAPSING-REMITTING MULTIPLE SCLEROSIS and CROHN'S DISEASE.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 27, 2006 EMA
Nov. 23, 2004 FDA BIOGEN IDEC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 12129.33 12.97 4133 94990 38831 50467170
Progressive multifocal leukoencephalopathy 3516.87 12.97 1178 97945 10279 50495722
Immune reconstitution inflammatory syndrome 2443.65 12.97 750 98373 4766 50501235
General symptom 1747.84 12.97 483 98640 1980 50504021
Urinary tract infection 1645.47 12.97 2103 97020 221917 50284084
Malaise 1200.40 12.97 2259 96864 333273 50172728
Drug specific antibody present 1123.18 12.97 369 98754 2999 50503002
Opportunistic infection 1089.59 12.97 307 98816 1371 50504630
Abortion spontaneous 1009.09 12.97 756 98367 41016 50464985
Prescribed underdose 880.11 12.97 486 98637 15463 50490538
Poor venous access 790.42 12.97 392 98731 9948 50496053
Balance disorder 654.93 12.97 748 98375 69842 50436159
Gait disturbance 583.97 12.97 1050 98073 148955 50357046
Fall 533.80 12.97 1651 97472 333281 50172720
Cognitive disorder 514.99 12.97 528 98595 43595 50462406
Memory impairment 502.76 12.97 695 98428 78665 50427336
Magnetic resonance imaging abnormal 455.69 12.97 179 98944 2539 50503462
Off label use 455.03 12.97 181 98942 474245 50031756
Central nervous system lesion 452.76 12.97 263 98860 9226 50496775
Maternal exposure during pregnancy 442.42 12.97 970 98153 158808 50347193
Seizure 397.08 12.97 776 98347 117098 50388903
Secondary progressive multiple sclerosis 391.24 12.97 131 98992 1135 50504866
Herpes zoster 381.07 12.97 574 98549 70212 50435789
Loss of control of legs 372.04 12.97 127 98996 1174 50504827
Neoplasm malignant 371.76 12.97 334 98789 23381 50482620
Breast cancer 353.47 12.97 428 98695 42462 50463539
Muscular weakness 347.61 12.97 648 98475 94365 50411636
Diarrhoea 331.15 12.97 401 98722 588075 49917926
Toxicity to various agents 316.14 12.97 27 99096 212472 50293529
Caesarean section 301.53 12.97 248 98875 15391 50490610
Optic neuritis 289.62 12.97 176 98947 6714 50499287
Joint swelling 272.64 12.97 72 99051 245214 50260787
Drug interaction 269.78 12.97 36 99087 199585 50306416
Rheumatoid arthritis 265.61 12.97 40 99083 202510 50303491
Hypoaesthesia 258.71 12.97 686 98437 126571 50379430
Muscle spasticity 257.49 12.97 236 98887 16948 50489053
Contraindicated product administered 251.87 12.97 9 99114 148949 50357052
Decubitus ulcer 250.91 12.97 181 98942 9237 50496764
Invasive ductal breast carcinoma 225.40 12.97 142 98981 5779 50500222
JC polyomavirus test positive 221.58 12.97 83 99040 1026 50504975
Product use issue 219.49 12.97 20 99103 149455 50356546
Condition aggravated 218.80 12.97 158 98965 296900 50209101
Asthenia 214.84 12.97 1208 97915 317834 50188167
Nasopharyngitis 211.57 12.97 842 98281 192085 50313916
Drug hypersensitivity 210.31 12.97 115 99008 250895 50255106
Hypersensitivity 203.91 12.97 898 98225 214263 50291738
Mobility decreased 200.35 12.97 467 98656 79481 50426520
Glossodynia 198.83 12.97 6 99117 115563 50390438
Musculoskeletal disorder 197.55 12.97 205 98918 17144 50488857
Neutralising antibodies positive 196.40 12.97 53 99070 194 50505807
Drug delivery device placement 194.79 12.97 45 99078 67 50505934
Influenza 194.51 12.97 495 98628 89043 50416958
Acute kidney injury 193.19 12.97 103 99020 227955 50278046
Abdominal discomfort 189.88 12.97 109 99014 231532 50274469
Visual impairment 187.96 12.97 414 98709 67861 50438140
Injection site pain 183.27 12.97 8 99115 111016 50394985
Gait inability 177.79 12.97 285 98838 36742 50469259
Peripheral swelling 175.89 12.97 92 99031 205844 50300157
Neutropenia 174.94 12.97 38 99085 147927 50358074
Trigeminal neuralgia 169.21 12.97 94 99029 3021 50502980
Cystitis 167.88 12.97 308 98815 44256 50461745
Stress 167.49 12.97 343 98780 53450 50452551
Progressive multiple sclerosis 167.39 12.97 61 99062 694 50505307
Febrile neutropenia 164.71 12.97 6 99117 97661 50408340
Surgery 161.05 12.97 244 98879 29961 50476040
Neuromyelitis optica spectrum disorder 158.43 12.97 60 99063 766 50505235
Hysterectomy 158.13 12.97 128 98995 7762 50498239
Dyspnoea 157.32 12.97 549 98574 547059 49958942
Road traffic accident 156.57 12.97 215 98908 24137 50481864
Product use in unapproved indication 156.10 12.97 21 99102 115798 50390203
Alopecia 154.91 12.97 151 98972 244896 50261105
Malignant melanoma 153.71 12.97 140 98983 9968 50496033
Arthralgia 150.70 12.97 405 98718 438297 50067704
Systemic lupus erythematosus 149.19 12.97 45 99078 140577 50365424
Decreased immune responsiveness 146.22 12.97 93 99030 3848 50502153
Peroneal nerve palsy 141.56 12.97 94 99029 4189 50501812
Decreased appetite 139.95 12.97 113 99010 200810 50305191
Neurogenic bladder 135.77 12.97 79 99044 2778 50503223
Mental impairment 132.97 12.97 140 98983 11904 50494097
Hemiparesis 131.90 12.97 179 98944 19869 50486132
Vein disorder 131.30 12.97 90 99033 4229 50501772
Nausea 131.28 12.97 828 98295 704570 49801431
Weight increased 126.86 12.97 125 98998 201766 50304235
Swelling 125.49 12.97 125 98998 200747 50305254
Epilepsy 121.80 12.97 179 98944 21388 50484613
Drug intolerance 120.83 12.97 151 98972 218953 50287048
Exposure during pregnancy 120.83 12.97 43 99080 120972 50385029
Injection site erythema 115.60 12.97 8 99115 74928 50431073
Coordination abnormal 113.20 12.97 126 98997 11408 50494593
Intraductal proliferative breast lesion 109.38 12.97 66 99057 2484 50503517
Rash 103.58 12.97 473 98650 436998 50069003
Ankle fracture 102.85 12.97 140 98983 15582 50490419
Lower limb fracture 102.65 12.97 133 98990 14113 50491888
Pancytopenia 102.55 12.97 20 99103 84010 50421991
Intervertebral disc protrusion 102.05 12.97 160 98963 20233 50485768
Urosepsis 101.61 12.97 138 98985 15327 50490674
Stomatitis 101.18 12.97 36 99087 101308 50404693
Arthropathy 100.05 12.97 97 99026 157809 50348192
Completed suicide 99.76 12.97 68 99055 131821 50374180
Pericarditis 99.75 12.97 17 99106 78672 50427329
Therapeutic product effect incomplete 99.39 12.97 28 99095 91487 50414514
Hyponatraemia 97.96 12.97 33 99090 96106 50409895
Aphasia 97.43 12.97 189 98934 28305 50477696
Hospitalisation 97.27 12.97 10 99113 67927 50438074
Bladder disorder 96.60 12.97 95 99028 7448 50498553
Multiple sclerosis 93.27 12.97 154 98969 20339 50485662
Depression 89.79 12.97 593 98530 164830 50341171
Blood creatinine increased 89.08 12.97 20 99103 76140 50429861
Central venous catheterisation 88.46 12.97 54 99069 2076 50503925
Uterine leiomyoma 87.59 12.97 92 99031 7799 50498202
Thrombocytopenia 87.35 12.97 73 99050 127600 50378401
Loss of personal independence in daily activities 86.90 12.97 16 99107 70034 50435967
Speech disorder 86.09 12.97 205 98918 35343 50470658
Atrial fibrillation 85.97 12.97 46 99077 101699 50404302
Diplopia 85.33 12.97 143 98980 19117 50486884
C-reactive protein increased 85.05 12.97 14 99109 66460 50439541
Relapsing-remitting multiple sclerosis 84.90 12.97 33 99090 454 50505547
Breech presentation 84.40 12.97 42 99081 1072 50504929
Upper respiratory tract infection 83.93 12.97 302 98821 65596 50440405
Platelet count decreased 82.99 12.97 47 99076 100679 50405322
Disease progression 82.99 12.97 42 99081 95824 50410177
Adverse reaction 82.89 12.97 93 99030 8493 50497508
Cervical dysplasia 82.22 12.97 57 99066 2728 50503273
Haemoglobin decreased 81.91 12.97 77 99046 127139 50378862
Bronchitis 81.79 12.97 412 98711 103747 50402254
Electrocardiogram QT prolonged 81.62 12.97 5 99118 51881 50454120
Hip fracture 81.44 12.97 166 98957 25765 50480236
Vomiting 81.25 12.97 549 98574 460209 50045792
Abdominal pain 80.95 12.97 218 98905 236010 50269991
Lower respiratory tract infection 80.49 12.97 43 99080 95158 50410843
Thyroid cancer 80.10 12.97 66 99057 4103 50501898
Wrong technique in product usage process 79.91 12.97 8 99115 55502 50450499
No adverse event 77.41 12.97 190 98933 33388 50472613
Treatment failure 76.71 12.97 94 99029 137543 50368458
Nephrolithiasis 76.50 12.97 193 98930 34500 50471501
Blister 76.09 12.97 36 99087 85382 50420619
Renal impairment 75.30 12.97 27 99096 75634 50430367
Prolonged labour 74.56 12.97 31 99092 513 50505488
Ectopic pregnancy 74.33 12.97 50 99073 2277 50503724
Gastric bypass 74.04 12.97 42 99081 1406 50504595
Intentional overdose 73.93 12.97 16 99107 62488 50443513
Leukopenia 72.69 12.97 21 99102 67507 50438494
Intentional product use issue 72.32 12.97 30 99093 76888 50429113
Anaphylactic shock 71.74 12.97 136 98987 20019 50485982
Pleural effusion 71.53 12.97 35 99088 81419 50424582
Mental disorder 70.51 12.97 142 98981 21849 50484152
Pregnancy 69.93 12.97 169 98954 29408 50476593
Muscle spasms 69.25 12.97 452 98671 125101 50380900
Neuropathy peripheral 69.08 12.97 53 99070 96704 50409297
Anaemia 68.93 12.97 258 98865 252198 50253803
Helicobacter infection 66.96 12.97 9 99114 49693 50456308
Infection 66.67 12.97 572 98551 172382 50333619
JC virus granule cell neuronopathy 66.64 12.97 20 99103 116 50505885
White blood cell count increased 66.56 12.97 208 98915 42032 50463969
Infusion site extravasation 66.39 12.97 75 99048 6901 50499100
Psoriasis 66.36 12.97 26 99097 68974 50437027
Cardiac failure 66.28 12.97 33 99090 76007 50429994
Kidney infection 66.12 12.97 126 98997 18620 50487381
Migraine 65.71 12.97 307 98816 74973 50431028
Cervix carcinoma 65.62 12.97 48 99075 2502 50503499
Hypotension 64.69 12.97 240 98883 235229 50270772
Drug abuse 63.70 12.97 19 99104 59827 50446174
Dyspepsia 63.32 12.97 33 99090 74064 50431937
Urinary incontinence 63.31 12.97 158 98965 28050 50477951
Injection site reaction 62.98 12.97 11 99112 50021 50455980
Dyspnoea exertional 62.91 12.97 12 99111 51221 50454780
Herpes zoster necrotising retinopathy 62.85 12.97 12 99111 0 50506001
White blood cell count decreased 62.66 12.97 82 99041 116640 50389361
Therapeutic response decreased 62.58 12.97 9 99114 47222 50458779
Post lumbar puncture syndrome 62.55 12.97 28 99095 559 50505442
Lymphocytosis 62.51 12.97 44 99079 2158 50503843
Staphylococcal infection 62.35 12.97 182 98941 35434 50470567
Dysgraphia 61.39 12.97 47 99076 2626 50503375
Multiple organ dysfunction syndrome 61.36 12.97 12 99111 50325 50455676
Unevaluable event 60.52 12.97 9 99114 46057 50459944
Amnesia 60.17 12.97 201 98922 42059 50463942
Muscle injury 60.15 12.97 3 99120 37108 50468893
Cough 59.88 12.97 256 98867 241008 50264993
Constipation 59.43 12.97 177 98946 185531 50320470
Oxygen saturation decreased 59.16 12.97 35 99088 73213 50432788
Temperature intolerance 58.44 12.97 73 99050 7466 50498535
Incorrect dose administered 58.06 12.97 12 99111 48402 50457599
Breast cancer female 57.33 12.97 69 99054 6793 50499208
Epistaxis 56.88 12.97 27 99096 63927 50442074
Vision blurred 56.81 12.97 304 98819 78343 50427658
Hypoxia 56.70 12.97 15 99108 51108 50454893
Intentional product misuse 55.19 12.97 12 99111 46722 50459279
Gallbladder operation 54.60 12.97 39 99084 1958 50504043
Discomfort 53.33 12.97 81 99042 108299 50397702
Neutrophil count decreased 52.01 12.97 13 99110 46013 50459988
Focal dyscognitive seizures 51.96 12.97 43 99080 2689 50503312
Death 51.09 12.97 908 98215 324471 50181530
Pharyngitis streptococcal 51.02 12.97 74 99049 8734 50497267
Breast cancer stage I 50.17 12.97 37 99086 1953 50504048
Invasive lobular breast carcinoma 49.82 12.97 25 99098 650 50505351
Viral infection 49.42 12.97 150 98973 29836 50476165
Band sensation 49.30 12.97 25 99098 665 50505336
International normalised ratio increased 49.13 12.97 12 99111 43140 50462861
Weight decreased 48.25 12.97 246 98877 220999 50285002
Dysstasia 47.80 12.97 107 99016 17712 50488289
Lactic acidosis 47.50 12.97 5 99118 33350 50472651
Frustration tolerance decreased 47.31 12.97 57 99066 5617 50500384
Gastroenteritis viral 47.28 12.97 110 99013 18676 50487325
Foetal exposure timing unspecified 47.16 12.97 17 99106 187 50505814
Hypoglycaemia 47.07 12.97 23 99100 53558 50452443
Primary progressive multiple sclerosis 46.97 12.97 14 99109 79 50505922
Appendicitis perforated 46.67 12.97 32 99091 1504 50504497
Cardio-respiratory arrest 46.05 12.97 24 99099 53868 50452133
Tachycardia 45.85 12.97 78 99045 99685 50406316
Partial seizures 45.78 12.97 52 99071 4813 50501188
Red blood cell sedimentation rate increased 45.77 12.97 3 99120 29413 50476588
Upper limb fracture 45.62 12.97 98 99025 15775 50490226
Papillary thyroid cancer 45.34 12.97 35 99088 1980 50504021
Gastrointestinal haemorrhage 45.29 12.97 46 99077 73275 50432726
Somnolence 45.17 12.97 154 98969 154831 50351170
Clostridial infection 45.14 12.97 47 99076 3943 50502058
Ascites 44.88 12.97 8 99115 35853 50470148
Urticaria 44.51 12.97 418 98705 129143 50376858
Endometriosis 44.32 12.97 47 99076 4028 50501973
Head injury 44.22 12.97 125 98998 23895 50482106
Rhabdomyolysis 44.14 12.97 11 99112 39016 50466985
Drug reaction with eosinophilia and systemic symptoms 43.93 12.97 3 99120 28421 50477580
Sensory disturbance 43.57 12.97 81 99042 11748 50494253
Therapy non-responder 43.18 12.97 23 99100 50999 50455002
Antibody test positive 43.18 12.97 36 99087 2275 50503726
Escherichia urinary tract infection 43.17 12.97 75 99048 10320 50495681
Central nervous system lymphoma 42.81 12.97 29 99094 1336 50504665
Productive cough 42.80 12.97 25 99098 52669 50453332
Folliculitis 42.57 12.97 12 99111 39213 50466788
Myalgia 42.32 12.97 115 99008 124204 50381797
Blood pressure systolic increased 42.07 12.97 9 99114 35440 50470561
Metabolic acidosis 41.91 12.97 12 99111 38813 50467188
Bladder dysfunction 41.74 12.97 23 99100 727 50505274
Neurological symptom 41.47 12.97 48 99075 4534 50501467
Hyperhidrosis 41.01 12.97 70 99053 89356 50416645
Interstitial lung disease 40.74 12.97 27 99096 53149 50452852
Wound 40.59 12.97 92 99031 105702 50400299
Hypokalaemia 40.24 12.97 69 99054 87923 50418078
Meningioma 39.69 12.97 41 99082 3408 50502593
Hemianaesthesia 39.64 12.97 18 99105 372 50505629
Meningitis herpes 39.50 12.97 15 99108 193 50505808
Bipolar disorder 39.47 12.97 57 99066 6700 50499301
Renal failure 39.09 12.97 95 99028 106538 50399463
Adenocarcinoma of colon 38.99 12.97 33 99090 2129 50503872
Agraphia 38.82 12.97 10 99113 29 50505972
Cardiac failure congestive 38.75 12.97 66 99057 84316 50421685
Basal cell carcinoma 38.64 12.97 117 99006 23239 50482762
Hypertension 37.91 12.97 250 98873 210953 50295048
Medication error 37.45 12.97 12 99111 36092 50469909
Abdominal distension 37.31 12.97 53 99070 72850 50433151
Inflammation 37.13 12.97 34 99089 56878 50449123
Malignant melanoma in situ 37.06 12.97 22 99101 803 50505198
Blindness 36.95 12.97 95 99028 17174 50488827
Uhthoff's phenomenon 36.66 12.97 7 99116 0 50506001
Urostomy 36.66 12.97 7 99116 0 50506001
Abortion missed 36.64 12.97 28 99095 1560 50504441
Pain 36.23 12.97 861 98262 578042 49927959
Dry mouth 36.14 12.97 34 99089 56144 50449857
Ataxia 36.10 12.97 82 99041 13704 50492297
Wheezing 36.02 12.97 41 99082 62006 50443995
Oedema 35.94 12.97 51 99072 70130 50435871
Steroid therapy 35.39 12.97 11 99112 73 50505928
Chronic kidney disease 35.04 12.97 17 99106 39754 50466247
Ophthalmic herpes zoster 35.00 12.97 28 99095 1669 50504332
Blood creatine phosphokinase increased 34.98 12.97 5 99118 26362 50479639
Chronic lymphocytic leukaemia 34.85 12.97 32 99091 2301 50503700
Bradycardia 34.83 12.97 45 99078 64381 50441620
Breast cancer in situ 34.72 12.97 26 99097 1405 50504596
Meningoencephalitis herpetic 34.16 12.97 23 99100 1049 50504952
Female reproductive tract disorder 34.07 12.97 16 99107 358 50505643
Ovarian cancer 33.90 12.97 46 99077 5103 50500898
Oedema peripheral 33.64 12.97 177 98946 157784 50348217
Herpes zoster meningitis 33.61 12.97 10 99113 56 50505945
Melaena 33.60 12.97 6 99117 26858 50479143
Motor dysfunction 33.42 12.97 58 99065 7973 50498028
Blindness unilateral 33.31 12.97 46 99077 5189 50500812
Female genital operation 33.14 12.97 8 99115 16 50505985
Sinusitis 33.05 12.97 493 98630 170065 50335936
Dry skin 32.99 12.97 22 99101 43169 50462832
Nasal congestion 32.81 12.97 31 99092 51089 50454912
Bone marrow failure 32.80 12.97 7 99116 27617 50478384
Urinary tract infection pseudomonal 32.66 12.97 20 99103 773 50505228
Arthropod bite 32.44 12.97 49 99074 5996 50500005
Gastrooesophageal reflux disease 32.21 12.97 63 99060 76365 50429636
Irritable bowel syndrome 32.08 12.97 32 99091 51409 50454592
Abdominal pain upper 32.01 12.97 182 98941 159127 50346874
Lung adenocarcinoma 32.00 12.97 40 99083 4094 50501907
Skin exfoliation 31.76 12.97 13 99110 33599 50472402
Influenza like illness 31.73 12.97 207 98916 57252 50448749
Foot fracture 31.70 12.97 99 99024 19992 50486009
Tremor 31.48 12.97 354 98769 114549 50391452
Fibula fracture 31.45 12.97 34 99089 2978 50503023
Vaginal infection 31.29 12.97 49 99074 6187 50499814
Hypervolaemia 31.24 12.97 6 99117 25493 50480508
Cholestasis 31.07 12.97 6 99117 25395 50480606
Tibia fracture 31.02 12.97 41 99082 4434 50501567
Meningitis viral 31.02 12.97 23 99100 1224 50504777
Cholecystectomy 30.93 12.97 61 99062 9242 50496759
Therapeutic product effect decreased 30.93 12.97 149 98974 135901 50370100
Injection site haemorrhage 30.92 12.97 3 99120 21343 50484658
Post procedural infection 30.60 12.97 54 99069 7522 50498479
Adverse drug reaction 30.53 12.97 199 98924 55023 50450978
Depressed level of consciousness 30.51 12.97 34 99089 51919 50454082
Therapeutic procedure 30.27 12.97 19 99104 768 50505233
Paraparesis 30.23 12.97 28 99095 2036 50503965
Blood urea increased 30.09 12.97 5 99118 23580 50482421
Paraesthesia 30.07 12.97 364 98759 119879 50386122
Papilloma viral infection 30.06 12.97 23 99100 1284 50504717
Serotonin syndrome 29.89 12.97 6 99117 24707 50481294
Autoimmune hepatitis 29.60 12.97 53 99070 7466 50498535
Blood cholesterol increased 29.40 12.97 39 99084 55176 50450825
Foetal malposition 29.32 12.97 9 99114 57 50505944
Stevens-Johnson syndrome 29.15 12.97 4 99119 21748 50484253
Appendicitis 29.09 12.97 49 99074 6575 50499426
Blood pressure increased 29.00 12.97 148 98975 132984 50373017
Sleep disorder 28.96 12.97 42 99081 57241 50448760
Colon cancer 28.91 12.97 57 99066 8634 50497367
Pruritus allergic 28.63 12.97 21 99102 1099 50504902
Arrested labour 28.57 12.97 12 99111 204 50505797
Back disorder 28.54 12.97 59 99064 9246 50496755
Oral pain 28.42 12.97 7 99116 25026 50480975
Cellulitis 28.20 12.97 236 98887 70562 50435439
Dysarthria 27.96 12.97 146 98977 37257 50468744
Fluid retention 27.76 12.97 35 99088 50614 50455387
Rectal haemorrhage 27.66 12.97 21 99102 38537 50467464
Red blood cell nucleated morphology present 27.51 12.97 7 99116 19 50505982
Neutralising antibodies 27.48 12.97 8 99115 41 50505960
Herpes simplex encephalitis 27.36 12.97 13 99110 299 50505702
Herpes simplex meningitis 27.32 12.97 8 99115 42 50505959
Accidental exposure to product 27.06 12.97 6 99117 23051 50482950
Mammoplasty 26.89 12.97 15 99108 486 50505515
Incontinence 26.82 12.97 60 99063 9925 50496076
Plasma cell myeloma 26.68 12.97 14 99109 31308 50474693
Progressive relapsing multiple sclerosis 26.52 12.97 7 99116 23 50505978
Low birth weight baby 26.49 12.97 44 99079 5837 50500164
Major depression 26.44 12.97 48 99075 6836 50499165
Hepatocellular injury 26.25 12.97 9 99114 25938 50480063
Mouth ulceration 26.22 12.97 11 99112 28013 50477988
Palpitations 26.12 12.97 96 99027 94410 50411591
Circulatory collapse 26.05 12.97 4 99119 19996 50486005
Hypocalcaemia 25.95 12.97 10 99113 26806 50479195
Headache 25.89 12.97 1226 97897 505309 50000692
Tenderness 25.89 12.97 3 99120 18562 50487439
Ejection fraction decreased 25.80 12.97 3 99120 18517 50487484
Hypercalcaemia 25.61 12.97 7 99116 23345 50482656
Sedation 25.60 12.97 14 99109 30596 50475405
Product administration error 25.53 12.97 4 99119 19695 50486306
Colon cancer metastatic 25.46 12.97 19 99104 1021 50504980
Anal incontinence 25.40 12.97 64 99059 11426 50494575
Post procedural complication 25.30 12.97 76 99047 15028 50490973
Overdose 25.20 12.97 105 99018 99622 50406379
Multiple allergies 25.18 12.97 53 99070 8410 50497591
Postoperative wound infection 25.13 12.97 53 99070 8422 50497579
Fibroadenoma of breast 25.12 12.97 13 99110 361 50505640
Rhinorrhoea 24.93 12.97 39 99084 51544 50454457
Depression suicidal 24.87 12.97 22 99101 1507 50504494
Drug level increased 24.77 12.97 4 99119 19264 50486737
Hyperglycaemia 24.65 12.97 21 99102 36384 50469617
Human papilloma virus test positive 24.54 12.97 14 99109 474 50505527
Blindness transient 24.53 12.97 31 99092 3207 50502794
Fatigue 24.21 12.97 1651 97472 705950 49800051
Therapy interrupted 24.15 12.97 5 99118 20147 50485854
Bladder catheterisation 24.06 12.97 11 99112 231 50505770
Knee operation 24.05 12.97 38 99085 4835 50501166
Flatulence 23.88 12.97 14 99109 29444 50476557
JC polyomavirus test 23.87 12.97 7 99116 37 50505964
Incorrect route of product administration 23.72 12.97 4 99119 18662 50487339
Dry eye 23.64 12.97 17 99106 32078 50473923
Delirium 23.54 12.97 24 99099 38168 50467833
Infectious mononucleosis 23.25 12.97 22 99101 1644 50504357
Plasmablastic lymphoma 23.18 12.97 10 99113 182 50505819
Pneumonia aspiration 23.16 12.97 121 99002 30883 50475118
Pulmonary hypertension 22.97 12.97 19 99104 33398 50472603
Blood glucose increased 22.77 12.97 68 99055 71256 50434745
Injury 22.70 12.97 38 99085 48887 50457114
Precancerous cells present 22.55 12.97 19 99104 1218 50504783
Metastases to bone 22.55 12.97 4 99119 17991 50488010
Cardiac arrest 22.45 12.97 86 99037 83565 50422436
Haemoptysis 22.42 12.97 11 99112 25562 50480439
Dysphemia 22.30 12.97 25 99098 2281 50503720
Uterine cancer 21.99 12.97 32 99091 3788 50502213
Lymphocyte count increased 21.90 12.97 28 99095 2931 50503070
Hypomagnesaemia 21.81 12.97 9 99114 23147 50482854
Fibromyalgia 21.74 12.97 34 99089 44944 50461057
Pain in jaw 21.65 12.97 26 99097 38402 50467599
Bile acid malabsorption 21.53 12.97 9 99114 151 50505850
Catheter placement 21.40 12.97 23 99100 2001 50504000
Myelitis transverse 21.34 12.97 17 99106 1007 50504994
Vertigo 21.29 12.97 174 98949 51658 50454343
Pneumonia 21.28 12.97 925 98198 377476 50128525
Pneumonitis 21.26 12.97 16 99107 29494 50476507
CD4 lymphocytes decreased 21.25 12.97 19 99104 1320 50504681
Blood lactate dehydrogenase increased 21.20 12.97 6 99117 19556 50486445
Inappropriate schedule of product administration 21.16 12.97 71 99052 71760 50434241
Ventricular tachycardia 20.99 12.97 3 99120 15818 50490183
Tooth infection 20.86 12.97 68 99055 14044 50491957
Anembryonic gestation 20.81 12.97 13 99110 521 50505480
Erythema 20.74 12.97 185 98938 146229 50359772
Perinatal stroke 20.71 12.97 5 99118 10 50505991
Concussion 20.67 12.97 46 99077 7582 50498419
Myelitis 20.56 12.97 18 99105 1216 50504785
Immune system disorder 20.55 12.97 48 99075 8169 50497832
Drug ineffective for unapproved indication 20.49 12.97 8 99115 21273 50484728
Colour blindness acquired 20.47 12.97 7 99116 65 50505936
Blood pressure diastolic decreased 20.45 12.97 4 99119 16777 50489224
Blood pressure fluctuation 20.43 12.97 24 99099 35799 50470202
Mammogram abnormal 20.42 12.97 14 99109 658 50505343
Pineal gland cyst 20.39 12.97 5 99118 11 50505990
Infusion site haematoma 20.39 12.97 10 99113 247 50505754
Cervix carcinoma stage III 20.26 12.97 6 99117 33 50505968
Rebound effect 20.25 12.97 28 99095 3161 50502840
Drug resistance 20.25 12.97 6 99117 18983 50487018
Face oedema 20.23 12.97 5 99118 17834 50488167
Neurogenic bowel 20.20 12.97 8 99115 116 50505885
Animal bite 20.10 12.97 24 99099 2343 50503658
Pulmonary oedema 20.05 12.97 41 99082 48897 50457104
Tubulointerstitial nephritis 19.91 12.97 3 99120 15208 50490793
Paternal exposure before pregnancy 19.82 12.97 6 99117 36 50505965
Insomnia 19.81 12.97 233 98890 174632 50331369
Product administered to patient of inappropriate age 19.64 12.97 25 99098 2605 50503396
Hepatic function abnormal 19.62 12.97 21 99102 32660 50473341
Gastric banding 19.58 12.97 7 99116 75 50505926
Flushing 19.50 12.97 209 98914 66806 50439195
Gastroenteritis cryptosporidial 19.50 12.97 7 99116 76 50505925
Endometrial cancer 19.35 12.97 26 99097 2857 50503144
Pyelonephritis 19.33 12.97 69 99054 14920 50491081
Respiratory tract infection 19.32 12.97 118 99005 31899 50474102
Ear infection 19.15 12.97 101 99022 25869 50480132
Lung cancer metastatic 19.04 12.97 23 99100 2272 50503729
Bone pain 18.99 12.97 40 99083 47189 50458812
Quadriplegia 18.96 12.97 20 99103 1703 50504298
Post-traumatic headache 18.81 12.97 5 99118 17 50505984
Abortion 18.80 12.97 22 99101 2102 50503899
Orthostatic hypotension 18.77 12.97 18 99105 29463 50476538
Joint stiffness 18.73 12.97 19 99104 30289 50475712
Impaired self-care 18.70 12.97 20 99103 1731 50504270
Cervical spinal stenosis 18.68 12.97 21 99102 1922 50504079
Injection site mass 18.56 12.97 4 99119 15676 50490325
Feeling hot 18.55 12.97 136 98987 39066 50466935
Ovarian cystectomy 18.53 12.97 8 99115 146 50505855
Dysplastic naevus 18.53 12.97 8 99115 146 50505855
Magnetic resonance imaging head abnormal 18.45 12.97 20 99103 1757 50504244
Haematuria 18.31 12.97 14 99109 25599 50480402
Incorrect drug administration rate 18.26 12.97 24 99099 2582 50503419
Medical device change 18.21 12.97 10 99113 314 50505687
Partial seizures with secondary generalisation 18.15 12.97 10 99113 316 50505685
Hyperemesis gravidarum 18.14 12.97 12 99111 531 50505470
Gastrointestinal viral infection 18.13 12.97 15 99108 938 50505063
Ligament rupture 18.06 12.97 24 99099 2610 50503391
Diplegia 17.95 12.97 15 99108 951 50505050
Haemorrhage 17.75 12.97 50 99073 53391 50452610
Agitation 17.69 12.97 50 99073 53334 50452667
Restlessness 17.69 12.97 14 99109 25159 50480842
Frequent bowel movements 17.64 12.97 3 99120 13915 50492086
Lumbar puncture 17.62 12.97 6 99117 55 50505946
Night sweats 17.58 12.97 24 99099 33550 50472451
Muscle tightness 17.48 12.97 52 99071 10228 50495773
Osteoarthritis 17.47 12.97 72 99051 68534 50437467
Blepharospasm 17.41 12.97 25 99098 2923 50503078
Foetal heart rate deceleration abnormality 17.40 12.97 11 99112 450 50505551
Incision site pain 17.35 12.97 15 99108 996 50505005
Dysgeusia 17.35 12.97 31 99092 38885 50467116
Metastatic malignant melanoma 17.34 12.97 16 99107 1158 50504843
Appendicectomy 17.32 12.97 23 99100 2499 50503502
Micturition urgency 17.20 12.97 45 99078 8219 50497782
Generalised tonic-clonic seizure 17.18 12.97 99 99024 26211 50479790
Disease recurrence 17.07 12.97 9 99114 20072 50485929
Benign neoplasm 17.01 12.97 14 99109 869 50505132
Post procedural pneumonia 16.96 12.97 5 99118 27 50505974
Synovial sarcoma 16.96 12.97 5 99118 27 50505974
Panic attack 16.95 12.97 79 99044 19263 50486738
Status migrainosus 16.83 12.97 7 99116 116 50505885
Neuralgia 16.80 12.97 86 99037 21777 50484224
Squamous cell carcinoma of the cervix 16.76 12.97 9 99114 270 50505731
Sputum discoloured 16.74 12.97 3 99120 13392 50492609
Ligament sprain 16.73 12.97 52 99071 10473 50495528
Haematochezia 16.69 12.97 33 99090 39849 50466152
Pulmonary fibrosis 16.66 12.97 14 99109 24423 50481578
Conversion disorder 16.64 12.97 18 99105 1578 50504423
Cervicitis human papilloma virus 16.57 12.97 4 99119 8 50505993
Endometrial adenocarcinoma 16.56 12.97 15 99108 1060 50504941
Shock 16.48 12.97 10 99113 20640 50485361
Proteinuria 16.37 12.97 6 99117 16591 50489410
Withdrawal syndrome 16.30 12.97 7 99116 17583 50488418
Inappropriate antidiuretic hormone secretion 16.30 12.97 3 99120 13140 50492861
Herpes virus infection 16.22 12.97 32 99091 4849 50501152
Sinus tachycardia 16.14 12.97 11 99112 21343 50484658
Impaired healing 16.10 12.97 76 99047 69710 50436291
Joint effusion 16.09 12.97 3 99120 13018 50492983
Necrotising retinitis 16.06 12.97 9 99114 294 50505707
Cephalo-pelvic disproportion 15.98 12.97 8 99115 207 50505794
Paralysis 15.86 12.97 45 99078 8619 50497382
Pericardial effusion 15.86 12.97 16 99107 25573 50480428
Status epilepticus 15.85 12.97 60 99063 13346 50492655
Nutritional supplementation 15.71 12.97 3 99120 0 50506001
Gestational oedema 15.71 12.97 3 99120 0 50506001
Detrusor sphincter dyssynergia 15.71 12.97 3 99120 0 50506001
Iron metabolism disorder 15.71 12.97 3 99120 0 50506001
Intracranial haemangioma 15.71 12.97 3 99120 0 50506001
Borderline ovarian tumour 15.71 12.97 3 99120 0 50506001
Bed bug infestation 15.71 12.97 3 99120 0 50506001
Malignant melanoma stage I 15.62 12.97 5 99118 37 50505964
Disseminated intravascular coagulation 15.59 12.97 7 99116 17128 50488873
Bladder repair 15.54 12.97 6 99117 81 50505920
Lung adenocarcinoma stage IV 15.53 12.97 7 99116 142 50505859
Angina pectoris 15.53 12.97 17 99106 26171 50479830
Autoimmune haemolytic anaemia 15.50 12.97 28 99095 3971 50502030
Cholecystitis infective 15.47 12.97 17 99106 1517 50504484
Haematemesis 15.36 12.97 19 99104 27706 50478295
Cardiomegaly 15.34 12.97 6 99117 15939 50490062
Rash erythematous 15.32 12.97 28 99095 34824 50471177
Calculus bladder 15.30 12.97 11 99112 558 50505443
Metabolic surgery 15.28 12.97 14 99109 1004 50504997
Corneal decompensation 15.28 12.97 5 99118 40 50505961
Urinary tract disorder 15.27 12.97 21 99102 2359 50503642
Thermal burn 15.21 12.97 31 99092 4810 50501191
Sepsis 15.16 12.97 354 98769 132571 50373430
Brain stem syndrome 15.08 12.97 9 99114 332 50505669
Red blood cell count decreased 15.04 12.97 27 99096 33808 50472193
Herpes zoster infection neurological 15.02 12.97 7 99116 154 50505847
Prescribed overdose 14.88 12.97 5 99118 14595 50491406
Demyelination 14.85 12.97 35 99088 5991 50500010
Liver injury 14.82 12.97 16 99107 24790 50481211
Latent tuberculosis 14.71 12.97 20 99103 2223 50503778
Bursitis 14.70 12.97 13 99110 22122 50483879
Skin discolouration 14.68 12.97 26 99097 32731 50473270
Bladder spasm 14.68 12.97 16 99107 1414 50504587
Wound sepsis 14.65 12.97 7 99116 163 50505838
Imminent abortion 14.54 12.97 4 99119 16 50505985
Macular degeneration 14.54 12.97 5 99118 14383 50491618
Urinary tract infection staphylococcal 14.51 12.97 8 99115 253 50505748
Blood potassium increased 14.46 12.97 7 99116 16391 50489610
Blood albumin decreased 14.45 12.97 4 99119 13232 50492769
Expanded disability status scale score increased 14.40 12.97 9 99114 361 50505640
Transverse presentation 14.35 12.97 4 99119 17 50505984
Goitre 14.33 12.97 32 99091 5288 50500713
Infected skin ulcer 14.32 12.97 19 99104 2062 50503939
Pertussis 14.18 12.97 11 99112 627 50505374
Eye irritation 14.10 12.97 8 99115 17132 50488869
Drug withdrawal syndrome 14.09 12.97 17 99106 25064 50480937
Blood alkaline phosphatase increased 14.09 12.97 33 99090 37493 50468508
Tooth abscess 13.93 12.97 56 99067 12804 50493197
Accident 13.93 12.97 31 99092 5110 50500891
Ovarian mass 13.92 12.97 11 99112 644 50505357
Medical device removal 13.91 12.97 14 99109 1128 50504873
Astrocytoma malignant 13.82 12.97 4 99119 20 50505981
Pruritus 13.71 12.97 437 98686 283131 50222870
Oral infection 13.71 12.97 27 99096 4087 50501914
Nucleated red cells 13.64 12.97 3 99120 3 50505998
Gastrointestinal lymphoma 13.56 12.97 5 99118 59 50505942
Cellulitis staphylococcal 13.54 12.97 11 99112 670 50505331
Uterine cyst 13.51 12.97 9 99114 403 50505598
Cervix carcinoma stage I 13.51 12.97 4 99119 22 50505979
Hot flush 13.46 12.97 43 99080 44126 50461875
Proteus infection 13.40 12.97 12 99111 835 50505166
Septic shock 13.34 12.97 62 99061 57113 50448888
Ovarian neoplasm 13.34 12.97 12 99111 840 50505161
Pneumocystis jirovecii pneumonia 13.33 12.97 6 99117 14657 50491344
Vestibular neuronitis 13.33 12.97 10 99113 542 50505459
Paraplegia 13.32 12.97 20 99103 2434 50503567
H1N1 influenza 13.24 12.97 16 99107 1581 50504420
Emotional disorder 13.19 12.97 52 99071 11784 50494217
Tumefactive multiple sclerosis 13.19 12.97 5 99118 64 50505937
Relapsing multiple sclerosis 13.17 12.97 6 99117 125 50505876
Metastases to liver 13.12 12.97 12 99111 20092 50485909
Precancerous skin lesion 13.10 12.97 12 99111 860 50505141
Communication disorder 13.10 12.97 19 99104 2242 50503759
Type 2 diabetes mellitus 13.09 12.97 30 99093 34345 50471656
Clumsiness 13.00 12.97 17 99106 1819 50504182
Procedural complication 12.98 12.97 29 99094 4794 50501207

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 4478.49 15.56 1209 28010 10210 29535098
Progressive multifocal leukoencephalopathy 1766.46 15.56 554 28665 8165 29537143
Immune reconstitution inflammatory syndrome 900.44 15.56 325 28894 7477 29537831
Urinary tract infection 733.53 15.56 591 28628 71763 29473545
General symptom 669.60 15.56 157 29062 671 29544637
Opportunistic infection 379.26 15.56 113 29106 1376 29543932
Drug specific antibody present 357.50 15.56 123 29096 2438 29542870
Malaise 333.55 15.56 578 28641 159024 29386284
Gait disturbance 322.10 15.56 379 28840 72970 29472338
Prescribed underdose 285.87 15.56 144 29075 7642 29537666
Cognitive disorder 243.71 15.56 195 29024 23304 29522004
Balance disorder 240.26 15.56 233 28986 35937 29509371
Memory impairment 238.63 15.56 233 28986 36237 29509071
Fall 228.79 15.56 525 28694 176653 29368655
Magnetic resonance imaging abnormal 227.22 15.56 77 29142 1454 29543854
Secondary progressive multiple sclerosis 227.10 15.56 56 29163 308 29545000
Muscle spasticity 226.52 15.56 106 29113 4777 29540531
JC polyomavirus test positive 201.61 15.56 56 29163 520 29544788
Muscular weakness 199.84 15.56 275 28944 61777 29483531
Mobility decreased 195.90 15.56 179 29040 25601 29519707
Loss of control of legs 168.37 15.56 48 29171 494 29544814
Poor venous access 166.61 15.56 75 29144 3086 29542222
Drug interaction 162.06 15.56 8 29211 197377 29347931
Gait inability 150.24 15.56 133 29086 18242 29527066
Central nervous system lesion 149.46 15.56 84 29135 5564 29539744
Seizure 140.26 15.56 294 28925 92829 29452479
Decubitus ulcer 131.88 15.56 85 29134 7226 29538082
Herpes zoster 126.17 15.56 152 29067 29900 29515408
Urosepsis 123.93 15.56 95 29124 10651 29534657
Off label use 118.39 15.56 76 29143 300724 29244584
Hypersensitivity 118.35 15.56 198 29021 52705 29492603
Surgery 118.33 15.56 96 29123 11683 29533625
Acute kidney injury 115.81 15.56 59 29160 265208 29280100
Musculoskeletal disorder 114.95 15.56 69 29150 5171 29540137
Toxicity to various agents 111.16 15.56 19 29200 173642 29371666
Asthenia 110.18 15.56 462 28757 214788 29330520
Influenza 106.26 15.56 166 29053 41715 29503593
Cystitis 106.05 15.56 78 29141 8214 29537094
Neutropenia 97.34 15.56 9 29210 131702 29413606
Febrile neutropenia 97.26 15.56 3 29216 112237 29433071
Diarrhoea 92.66 15.56 116 29103 332582 29212726
Progressive multiple sclerosis 92.33 15.56 25 29194 209 29545099
Road traffic accident 91.68 15.56 94 29125 15467 29529841
Hypoaesthesia 90.11 15.56 177 29042 53290 29492018
Neoplasm malignant 88.60 15.56 96 29123 16829 29528479
Drug delivery device placement 85.69 15.56 21 29198 112 29545196
Nasopharyngitis 82.39 15.56 182 29037 59483 29485825
Drug ineffective 81.90 15.56 625 28594 362545 29182763
Neurogenic bladder 81.49 15.56 37 29182 1553 29543755
Anaemia 81.36 15.56 49 29170 200902 29344406
Multiple sclerosis 79.62 15.56 56 29163 5498 29539810
Primary progressive multiple sclerosis 77.53 15.56 16 29203 31 29545277
Visual impairment 72.90 15.56 116 29103 29592 29515716
Blood creatinine increased 71.19 15.56 3 29216 85099 29460209
Decreased appetite 68.43 15.56 29 29190 145313 29399995
Renal impairment 67.59 15.56 3 29216 81330 29463978
Coordination abnormal 65.22 15.56 55 29164 7059 29538249
Lower limb fracture 64.72 15.56 42 29177 3610 29541698
Infection 63.37 15.56 193 29026 76558 29468750
Dyspnoea 63.12 15.56 144 29075 326588 29218720
Neuromyelitis optica spectrum disorder 62.60 15.56 16 29203 104 29545204
Optic neuritis 58.17 15.56 37 29182 3072 29542236
Thrombocytopenia 57.19 15.56 31 29188 134792 29410516
Product use in unapproved indication 56.64 15.56 9 29210 86866 29458442
Depression 55.83 15.56 198 29021 84949 29460359
Urinary tract infection pseudomonal 55.43 15.56 22 29197 658 29544650
Haemoglobin decreased 53.65 15.56 20 29199 108355 29436953
Pancytopenia 53.36 15.56 9 29210 83159 29462149
Cellulitis 52.49 15.56 130 29089 45710 29499598
Hypotension 49.64 15.56 72 29147 194282 29351026
Condition aggravated 49.58 15.56 43 29176 146252 29399056
Hyponatraemia 48.92 15.56 5 29214 67628 29477680
Infusion site extravasation 48.27 15.56 33 29186 3094 29542214
Nausea 46.24 15.56 140 29079 289115 29256193
Drug abuse 44.40 15.56 12 29207 79871 29465437
Agraphia 44.11 15.56 9 29210 16 29545292
Cardiac failure 43.90 15.56 12 29207 79275 29466033
Nephrolithiasis 42.79 15.56 84 29135 25250 29520058
Rhabdomyolysis 42.70 15.56 5 29214 60803 29484505
Platelet count decreased 41.62 15.56 26 29193 104646 29440662
Hyperkalaemia 40.83 15.56 6 29213 61386 29483922
Somnolence 40.70 15.56 21 29198 93934 29451374
Gastrointestinal haemorrhage 40.50 15.56 14 29205 79519 29465789
Muscle spasms 39.80 15.56 148 29071 64934 29480374
Disease progression 39.07 15.56 16 29203 81900 29463408
JC virus granule cell neuronopathy 38.95 15.56 7 29212 3 29545305
No adverse event 37.15 15.56 64 29155 17414 29527894
White blood cell count decreased 37.06 15.56 18 29201 83344 29461964
Neutralising antibodies positive 36.99 15.56 10 29209 83 29545225
Intervertebral disc protrusion 36.59 15.56 44 29175 8626 29536682
Influenza like illness 36.42 15.56 77 29142 24393 29520915
Death 35.86 15.56 504 28715 341580 29203728
Foetal exposure timing unspecified 35.53 15.56 12 29207 224 29545084
Herpes zoster necrotising retinopathy 35.53 15.56 6 29213 0 29545308
Marburg's variant multiple sclerosis 35.53 15.56 6 29213 0 29545308
Prostate cancer 35.34 15.56 78 29141 25449 29519859
Trigeminal neuralgia 34.87 15.56 18 29201 1004 29544304
Abdominal pain 34.66 15.56 50 29169 135307 29410001
Epistaxis 34.50 15.56 5 29214 51699 29493609
Hip fracture 34.44 15.56 47 29172 10445 29534863
Weight increased 33.40 15.56 17 29202 76650 29468658
Renal failure 33.22 15.56 41 29178 118558 29426750
Malignant melanoma 32.97 15.56 38 29181 7123 29538185
Pleural effusion 31.24 15.56 16 29203 71892 29473416
Leukopenia 31.22 15.56 8 29211 55195 29490113
Chronic lymphocytic leukaemia 31.08 15.56 27 29192 3606 29541702
Escherichia urinary tract infection 31.00 15.56 25 29194 3014 29542294
Epilepsy 30.98 15.56 61 29158 18371 29526937
Staphylococcal infection 30.42 15.56 80 29139 29160 29516148
International normalised ratio increased 30.29 15.56 4 29215 44368 29500940
Mental disorder 29.74 15.56 49 29170 12856 29532452
Nutritional supplementation 29.61 15.56 5 29214 0 29545308
Neutrophil count decreased 29.57 15.56 4 29215 43563 29501745
Neuropathy peripheral 29.12 15.56 17 29202 71010 29474298
Cardiac failure congestive 29.10 15.56 20 29199 76561 29468747
Adverse reaction 28.67 15.56 23 29196 2752 29542556
Motor dysfunction 28.20 15.56 32 29187 5898 29539410
Product use issue 28.07 15.56 8 29211 51436 29493872
Testis cancer 27.97 15.56 15 29204 905 29544403
Peroneal nerve palsy 27.53 15.56 22 29197 2617 29542691
Metabolic acidosis 26.68 15.56 3 29216 37659 29507649
Decreased immune responsiveness 26.61 15.56 17 29202 1422 29543886
Upper respiratory tract infection 26.61 15.56 73 29146 27276 29518032
Stem cell transplant 26.10 15.56 19 29200 1968 29543340
Urinary incontinence 25.86 15.56 53 29166 16428 29528880
Drug hypersensitivity 25.81 15.56 18 29201 68388 29476920
Hemiparesis 25.64 15.56 49 29170 14437 29530871
Hypoglycaemia 25.50 15.56 8 29211 48338 29496970
Pneumonia aspiration 25.40 15.56 87 29132 36650 29508658
Relapsing-remitting multiple sclerosis 25.28 15.56 13 29206 719 29544589
Meningitis herpes 25.23 15.56 5 29214 7 29545301
Bipolar disorder 25.23 15.56 23 29196 3272 29542036
Multiple organ dysfunction syndrome 24.63 15.56 16 29203 63100 29482208
HIV test positive 24.60 15.56 8 29211 132 29545176
Glioblastoma 24.42 15.56 14 29205 962 29544346
Infected skin ulcer 24.38 15.56 16 29203 1401 29543907
CD8 lymphocytes decreased 24.30 15.56 7 29212 75 29545233
Appendicitis perforated 24.01 15.56 17 29202 1686 29543622
Antibody test positive 23.94 15.56 12 29207 629 29544679
C-reactive protein increased 23.93 15.56 7 29212 44256 29501052
Cardio-respiratory arrest 23.93 15.56 10 29209 50591 29494717
Haematochezia 23.71 15.56 4 29215 36979 29508329
Amnesia 23.60 15.56 62 29157 22581 29522727
Ascites 23.39 15.56 4 29215 36615 29508693
Chronic kidney disease 23.21 15.56 4 29215 36412 29508896
Hemianaesthesia 23.13 15.56 7 29212 90 29545218
Intentional overdose 22.93 15.56 5 29214 38523 29506785
Sinusitis 22.58 15.56 80 29139 34270 29511038
Central nervous system lymphoma 22.40 15.56 12 29207 722 29544586
Speech disorder 22.12 15.56 62 29157 23454 29521854
Ophthalmic herpes zoster 22.01 15.56 12 29207 748 29544560
Migraine 21.94 15.56 42 29177 12388 29532920
Vision blurred 21.80 15.56 88 29131 40088 29505220
Plasma cell myeloma 21.72 15.56 5 29214 37110 29508198
Mental impairment 21.46 15.56 35 29184 9106 29536202
Agitation 21.42 15.56 12 29207 51292 29494016
Tumefactive multiple sclerosis 21.38 15.56 5 29214 21 29545287
Tachycardia 21.37 15.56 24 29195 72386 29472922
Tremor 21.36 15.56 135 29084 73403 29471905
Paraparesis 21.22 15.56 16 29203 1748 29543560
Gallbladder operation 20.96 15.56 10 29209 470 29544838
Intervertebral disc operation 20.75 15.56 8 29211 221 29545087
Dysstasia 20.50 15.56 37 29182 10437 29534871
Aphasia 20.45 15.56 53 29166 19145 29526163
Bladder catheterisation 20.44 15.56 10 29209 497 29544811
Kidney infection 20.14 15.56 24 29195 4659 29540649
Peripheral swelling 20.07 15.56 20 29199 63719 29481589
Uhthoff's phenomenon 20.02 15.56 4 29215 6 29545302
Stomatitis 19.82 15.56 6 29213 37107 29508201
Temperature intolerance 19.70 15.56 19 29200 2902 29542406
Intentional product misuse 19.64 15.56 5 29214 34656 29510652
Oedema peripheral 19.60 15.56 46 29173 103511 29441797
Dysgraphia 19.18 15.56 16 29203 2022 29543286
Bradycardia 19.09 15.56 22 29197 65607 29479701
Arthropod bite 18.97 15.56 17 29202 2366 29542942
Overdose 18.96 15.56 31 29188 79788 29465520
Ill-defined disorder 18.85 15.56 38 29181 11640 29533668
B-cell lymphoma 18.83 15.56 21 29198 3797 29541511
Spinal operation 18.78 15.56 17 29202 2397 29542911
Lyme disease 18.68 15.56 11 29208 795 29544513
Herpes simplex encephalitis 18.53 15.56 8 29211 297 29545011
Bladder disorder 18.51 15.56 18 29201 2776 29542532
Hypoxia 18.50 15.56 12 29207 47367 29497941
Constipation 18.35 15.56 55 29164 114105 29431203
Myalgia 18.28 15.56 28 29191 73991 29471317
Depression suicidal 18.24 15.56 13 29206 1302 29544006
Vomiting 18.14 15.56 129 29090 212131 29333177
CD4 lymphocytes decreased 18.14 15.56 14 29205 1584 29543724
Headache 17.97 15.56 256 28963 173751 29371557
Osteomyelitis 17.97 15.56 41 29178 13668 29531640
Ataxia 17.91 15.56 38 29181 12065 29533243
Urinary tract disorder 17.84 15.56 15 29204 1917 29543391
Wernicke-Korsakoff syndrome 17.76 15.56 3 29216 0 29545308
Laryngeal cancer stage 0 17.76 15.56 3 29216 0 29545308
Drug rehabilitation 17.76 15.56 3 29216 0 29545308
Blood creatine phosphokinase increased 17.71 15.56 9 29210 40635 29504673
Bone marrow failure 17.52 15.56 3 29216 27446 29517862
Basal cell carcinoma 17.31 15.56 46 29173 16864 29528444
Vein disorder 17.21 15.56 11 29208 921 29544387
Concussion 17.09 15.56 15 29204 2031 29543277
Blindness 16.93 15.56 37 29182 11986 29533322
Lumbar radiculopathy 16.88 15.56 10 29209 731 29544577
Thrombocytopenia neonatal 16.87 15.56 8 29211 371 29544937
Immune system disorder 16.75 15.56 21 29198 4296 29541012
Stress 16.73 15.56 53 29166 21437 29523871
Hypokalaemia 16.68 15.56 15 29204 50188 29495120
Focal dyscognitive seizures 16.56 15.56 12 29207 1234 29544074
Joint swelling 16.29 15.56 15 29204 49615 29495693
Urticaria 16.28 15.56 101 29118 54559 29490749
Central venous catheterisation 16.15 15.56 11 29208 1025 29544283
Abdominal distension 16.13 15.56 13 29206 45898 29499410
Rectal haemorrhage 16.06 15.56 7 29212 34542 29510766
Blood urea increased 16.03 15.56 4 29215 28108 29517200
Injection site pain 16.01 15.56 6 29213 32440 29512868
Pneumonitis 15.98 15.56 4 29215 28040 29517268
Appendicectomy 15.97 15.56 10 29209 808 29544500
Rheumatoid arthritis 15.78 15.56 6 29213 32146 29513162
Hip arthroplasty 15.74 15.56 19 29200 3739 29541569
Head injury 15.71 15.56 43 29176 16038 29529270
Calculus bladder 15.70 15.56 10 29209 832 29544476
Back disorder 15.58 15.56 24 29195 5949 29539359

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 12377.70 13.23 3865 90081 37270 64367516
Progressive multifocal leukoencephalopathy 4735.35 13.23 1536 92410 16696 64388090
Immune reconstitution inflammatory syndrome 3043.73 13.23 1003 92943 11467 64393319
Urinary tract infection 1895.69 13.23 1991 91955 229605 64175181
General symptom 1391.14 13.23 371 93575 1857 64402929
Drug specific antibody present 987.50 13.23 346 93600 4808 64399978
Abortion spontaneous 953.77 13.23 541 93405 24602 64380184
Prescribed underdose 870.34 13.23 455 93491 17560 64387226
Malaise 793.78 13.23 1766 92180 394481 64010305
Fall 688.05 13.23 1723 92223 415103 63989683
Poor venous access 664.41 13.23 336 93610 12081 64392705
Balance disorder 564.89 13.23 653 93293 83273 64321513
Gait disturbance 523.84 13.23 916 93030 171239 64233547
Magnetic resonance imaging abnormal 464.79 13.23 174 93772 2949 64401837
Seizure 462.88 13.23 853 93093 166039 64238747
Maternal exposure during pregnancy 458.53 13.23 629 93317 95255 64309531
Secondary progressive multiple sclerosis 414.72 13.23 127 93819 1116 64403670
Off label use 411.31 13.23 205 93741 632601 63772185
Central nervous system lesion 406.65 13.23 239 93707 11610 64393176
Memory impairment 403.49 13.23 558 93388 85124 64319662
Drug interaction 396.05 13.23 36 93910 362047 64042739
Loss of control of legs 391.51 13.23 131 93815 1568 64403218
Herpes zoster 386.88 13.23 525 93421 78662 64326124
Toxicity to various agents 384.86 13.23 41 93905 363472 64041314
Muscle spasticity 362.19 13.23 252 93694 16417 64388369
Breast cancer 333.33 13.23 302 93644 28846 64375940
Muscular weakness 324.44 13.23 628 93318 126710 64278076
Hypersensitivity 321.50 13.23 811 93135 195641 64209145
Cognitive disorder 315.36 13.23 395 93551 54692 64350094
Acute kidney injury 293.75 13.23 144 93802 449096 63955690
JC polyomavirus test positive 285.62 13.23 96 93850 1166 64403620
Decubitus ulcer 273.78 13.23 195 93751 13184 64391602
Optic neuritis 271.39 13.23 161 93785 7955 64396831
Diarrhoea 260.19 13.23 408 93538 722296 63682490
Invasive ductal breast carcinoma 259.66 13.23 133 93813 4909 64399877
Caesarean section 258.01 13.23 176 93770 11098 64393688
Nasopharyngitis 256.04 13.23 745 93201 195328 64209458
Drug delivery device placement 250.81 13.23 58 93888 137 64404649
Febrile neutropenia 244.80 13.23 6 93940 187651 64217135
Influenza 239.68 13.23 499 93447 106032 64298754
Hypoaesthesia 236.54 13.23 583 93363 138525 64266261
Neutropenia 236.38 13.23 34 93912 239590 64165196
Cystitis 233.11 13.23 299 93647 42376 64362410
Gait inability 220.74 13.23 290 93656 42078 64362708
Road traffic accident 206.23 13.23 239 93707 30506 64374280
Musculoskeletal disorder 203.66 13.23 185 93761 17721 64387065
Urosepsis 197.72 13.23 200 93746 21894 64382892
Mobility decreased 196.46 13.23 405 93541 85435 64319351
Condition aggravated 195.36 13.23 154 93792 372272 64032514
Trigeminal neuralgia 189.62 13.23 92 93854 3017 64401769
Asthenia 182.11 13.23 1155 92791 426889 63977897
Surgery 182.03 13.23 215 93731 27998 64376788
Hysterectomy 172.96 13.23 102 93844 4983 64399803
Opportunistic infection 169.09 13.23 81 93865 2581 64402205
Visual impairment 168.90 13.23 349 93597 73728 64331058
Product use in unapproved indication 165.23 13.23 29 93917 176589 64228197
Progressive multiple sclerosis 162.31 13.23 56 93890 740 64404046
Neuromyelitis optica spectrum disorder 162.08 13.23 57 93889 800 64403986
Lower limb fracture 162.04 13.23 144 93802 13401 64391385
Neutralising antibodies positive 159.74 13.23 43 93903 224 64404562
Decreased appetite 159.54 13.23 107 93839 281182 64123604
Rheumatoid arthritis 151.47 13.23 28 93918 164266 64240520
Product use issue 150.77 13.23 21 93925 151694 64253092
Neurogenic bladder 148.35 13.23 82 93864 3537 64401249
Dyspnoea 144.80 13.23 549 93397 718125 63686661
Pancytopenia 142.02 13.23 20 93926 143289 64261497
Joint swelling 140.54 13.23 69 93877 215313 64189473
Drug hypersensitivity 135.44 13.23 90 93856 237725 64167061
Decreased immune responsiveness 135.19 13.23 83 93863 4365 64400421
Ankle fracture 134.99 13.23 135 93811 14575 64390211
Blood creatinine increased 134.43 13.23 19 93927 135763 64269023
Thrombocytopenia 133.92 13.23 80 93866 223721 64181065
Hip fracture 132.71 13.23 180 93766 26919 64377867
Malignant melanoma 132.10 13.23 126 93820 12838 64391948
Epilepsy 129.51 13.23 199 93747 33332 64371454
Drug abuse 127.65 13.23 20 93926 132354 64272432
Renal impairment 126.63 13.23 22 93924 134995 64269791
Hyperkalaemia 125.49 13.23 5 93941 101124 64303662
Stress 125.03 13.23 274 93672 60260 64344526
Injection site pain 124.53 13.23 10 93936 111398 64293388
Peripheral swelling 123.40 13.23 76 93870 209077 64195709
Hyponatraemia 123.13 13.23 32 93914 148307 64256479
Intervertebral disc protrusion 120.64 13.23 148 93798 20043 64384743
Contraindicated product administered 119.63 13.23 10 93936 107819 64296967
Depression 115.65 13.23 551 93395 182740 64222046
Multiple sclerosis 113.43 13.23 139 93807 18802 64385984
Hemiparesis 112.36 13.23 175 93771 29652 64375134
Anaemia 109.89 13.23 243 93703 378437 64026349
Platelet count decreased 108.97 13.23 54 93892 167657 64237129
Haemoglobin decreased 108.13 13.23 76 93870 194987 64209799
Vein disorder 106.04 13.23 69 93877 4018 64400768
Disease progression 105.93 13.23 37 93909 141643 64263143
Pregnancy 105.84 13.23 141 93805 20724 64384062
Intraductal proliferative breast lesion 105.74 13.23 55 93891 2096 64402690
Nephrolithiasis 105.69 13.23 211 93735 43472 64361314
Peroneal nerve palsy 105.28 13.23 76 93870 5245 64399541
Cardiac failure 103.48 13.23 32 93914 132341 64272445
Cervical dysplasia 103.42 13.23 52 93894 1844 64402942
Drug intolerance 103.21 13.23 74 93872 187918 64216868
Bronchitis 102.55 13.23 370 93576 108373 64296413
Upper respiratory tract infection 99.09 13.23 281 93665 72504 64332282
Hypotension 98.26 13.23 260 93686 380714 64024072
Coordination abnormal 98.11 13.23 115 93831 14849 64389937
Uterine leiomyoma 97.91 13.23 73 93873 5296 64399490
Muscle spasms 95.59 13.23 433 93513 140590 64264196
Electrocardiogram QT prolonged 95.08 13.23 5 93941 79443 64325343
Weight increased 94.24 13.23 103 93843 213245 64191541
Herpes zoster necrotising retinopathy 94.07 13.23 17 93929 0 64404786
Migraine 93.28 13.23 250 93696 62427 64342359
Therapeutic product effect incomplete 92.47 13.23 19 93927 103463 64301323
Abdominal pain 90.95 13.23 200 93746 312175 64092611
Stomatitis 90.27 13.23 24 93922 109581 64295205
Infusion site extravasation 88.44 13.23 76 93870 6761 64398025
Rhabdomyolysis 85.88 13.23 15 93931 91711 64313075
Breech presentation 85.44 13.23 33 93913 611 64404175
Gastrointestinal haemorrhage 85.34 13.23 43 93903 132269 64272517
Injection site erythema 83.04 13.23 5 93941 70795 64333991
Mental impairment 82.21 13.23 110 93836 16233 64388553
Multiple organ dysfunction syndrome 82.02 13.23 23 93923 101390 64303396
Leukopenia 81.81 13.23 23 93923 101219 64303567
C-reactive protein increased 81.61 13.23 19 93927 94890 64309896
Intentional overdose 81.44 13.23 16 93930 89928 64314858
Staphylococcal infection 81.39 13.23 208 93738 50470 64354316
Sinusitis 80.89 13.23 423 93523 145505 64259281
Kidney infection 80.61 13.23 114 93832 17724 64387062
JC virus granule cell neuronopathy 80.43 13.23 22 93924 123 64404663
Nausea 79.23 13.23 748 93198 785052 63619734
Prolonged labour 78.59 13.23 28 93918 409 64404377
Glossodynia 77.64 13.23 4 93942 64692 64340094
Gallbladder operation 76.45 13.23 41 93905 1664 64403122
Escherichia urinary tract infection 76.42 13.23 91 93855 11946 64392840
Pleural effusion 75.99 13.23 45 93901 126514 64278272
Interstitial lung disease 75.70 13.23 24 93922 97708 64307078
Hospitalisation 75.66 13.23 10 93936 75197 64329589
Arthralgia 74.55 13.23 361 93585 441899 63962887
Urinary tract infection pseudomonal 74.34 13.23 38 93908 1396 64403390
Urticaria 74.19 13.23 416 93530 146901 64257885
Epistaxis 72.70 13.23 26 93920 98105 64306681
White blood cell count decreased 72.14 13.23 74 93872 157763 64247023
International normalised ratio increased 71.85 13.23 14 93932 79153 64325633
Intentional product misuse 71.81 13.23 10 93936 72285 64332501
Urinary incontinence 71.66 13.23 161 93785 35990 64368796
Dyspnoea exertional 71.38 13.23 11 93935 73719 64331067
Relapsing-remitting multiple sclerosis 71.24 13.23 34 93912 1074 64403712
Central venous catheterisation 70.44 13.23 46 93900 2695 64402091
Anaphylactic shock 70.39 13.23 144 93802 30184 64374602
Aphasia 69.99 13.23 172 93774 40734 64364052
Wrong technique in product usage process 69.45 13.23 7 93939 64967 64339819
Neutrophil count decreased 69.33 13.23 14 93932 77182 64327604
Completed suicide 69.20 13.23 139 93807 224275 64180511
Atrial fibrillation 68.70 13.23 89 93857 171000 64233786
Renal failure 68.44 13.23 99 93847 181589 64223197
Cellulitis 68.30 13.23 294 93652 93363 64311423
Diplopia 68.02 13.23 132 93814 26633 64378153
Headache 67.89 13.23 1115 92831 528352 63876434
Gastroenteritis viral 67.77 13.23 111 93835 19618 64385168
Neuropathy peripheral 67.49 13.23 44 93902 117481 64287305
Gastric bypass 66.84 13.23 32 93914 1018 64403768
Head injury 65.92 13.23 147 93799 32695 64372091
Post lumbar puncture syndrome 65.82 13.23 28 93918 671 64404115
Bladder disorder 65.29 13.23 68 93878 7699 64397087
Lactic acidosis 64.65 13.23 7 93939 61403 64343383
Abdominal discomfort 64.21 13.23 104 93842 182218 64222568
Treatment failure 64.06 13.23 46 93900 116770 64288016
Infection 63.52 13.23 474 93472 184406 64220380
Thyroid cancer 63.42 13.23 50 93896 3941 64400845
Drug reaction with eosinophilia and systemic symptoms 63.07 13.23 4 93942 54213 64350573
Somnolence 62.90 13.23 126 93820 203519 64201267
Focal dyscognitive seizures 62.84 13.23 46 93900 3244 64401542
Hypoxia 62.55 13.23 25 93921 88124 64316662
Cardio-respiratory arrest 61.92 13.23 33 93913 98360 64306426
Metabolic acidosis 61.41 13.23 14 93932 70944 64333842
Hypoglycaemia 61.36 13.23 27 93919 89865 64314921
Speech disorder 61.08 13.23 182 93764 48259 64356527
Ascites 60.59 13.23 9 93937 61992 64342794
Cholecystectomy 59.90 13.23 66 93880 7966 64396820
Upper limb fracture 59.90 13.23 90 93856 14776 64390010
Appendicitis perforated 59.76 13.23 42 93904 2778 64402008
Mental disorder 59.53 13.23 124 93822 26321 64378465
Vision blurred 59.44 13.23 275 93671 90041 64314745
Loss of personal independence in daily activities 59.39 13.23 16 93930 72438 64332348
Melaena 59.29 13.23 5 93941 53543 64351243
Oxygen saturation decreased 59.04 13.23 42 93904 107134 64297652
Meningitis herpes 58.98 13.23 19 93927 200 64404586
Incorrect dose administered 58.97 13.23 9 93937 60756 64344030
Central nervous system lymphoma 58.53 13.23 36 93910 1899 64402887
Papillary thyroid cancer 57.67 13.23 38 93908 2260 64402526
Pharyngitis streptococcal 57.46 13.23 67 93879 8601 64396185
Breast cancer stage I 57.11 13.23 34 93912 1690 64403096
Rash maculo-papular 56.13 13.23 3 93943 47023 64357763
Chronic lymphocytic leukaemia 55.88 13.23 48 93898 4267 64400519
Foot fracture 55.53 13.23 97 93849 18060 64386726
Primary progressive multiple sclerosis 55.43 13.23 15 93931 80 64404706
Uhthoff's phenomenon 55.33 13.23 10 93936 0 64404786
Cervix carcinoma 54.93 13.23 34 93912 1814 64402972
Ectopic pregnancy 54.84 13.23 32 93914 1532 64403254
Bradycardia 54.50 13.23 55 93891 118164 64286622
Breast cancer in situ 53.77 13.23 26 93920 846 64403940
Cardiac failure congestive 53.37 13.23 67 93879 130513 64274273
Endometriosis 53.24 13.23 39 93907 2753 64402033
Tachycardia 52.96 13.23 85 93861 149494 64255292
Amnesia 52.24 13.23 172 93774 48097 64356689
No adverse event 51.98 13.23 123 93823 28438 64376348
Adverse reaction 51.93 13.23 60 93886 7627 64397159
Cough 51.79 13.23 245 93701 301903 64102883
Bipolar disorder 51.19 13.23 56 93890 6705 64398081
Vomiting 51.04 13.23 535 93411 550582 63854204
Partial seizures 51.00 13.23 58 93888 7249 64397537
Myalgia 50.82 13.23 96 93850 158521 64246265
Alopecia 50.74 13.23 103 93843 165587 64239199
Influenza like illness 49.92 13.23 200 93746 61502 64343284
Intentional product use issue 49.16 13.23 40 93906 95324 64309462
Invasive lobular breast carcinoma 48.58 13.23 21 93925 524 64404262
Blood creatine phosphokinase increased 47.87 13.23 13 93933 58545 64346241
Therapeutic response decreased 47.84 13.23 9 93937 52179 64352607
Dysgraphia 47.80 13.23 40 93906 3431 64401355
Breast cancer female 47.12 13.23 47 93899 5056 64399730
Adverse drug reaction 46.54 13.23 159 93787 45305 64359481
Tibia fracture 46.23 13.23 45 93901 4700 64400086
Lower respiratory tract infection 44.78 13.23 43 93903 94571 64310215
Swelling 44.60 13.23 105 93841 160113 64244673
Bone marrow failure 44.53 13.23 8 93938 47944 64356842
Fatigue 44.38 13.23 1414 92532 747316 63657470
Lymphocytosis 44.10 13.23 39 93907 3605 64401181
Meningioma 43.92 13.23 40 93906 3842 64400944
Temperature intolerance 43.74 13.23 57 93889 8198 64396588
Psoriasis 43.73 13.23 25 93921 71678 64333108
Therapy non-responder 43.10 13.23 21 93925 65878 64338908
Rectal haemorrhage 43.09 13.23 18 93928 61799 64342987
Injection site reaction 42.87 13.23 8 93938 46656 64358130
Productive cough 42.57 13.23 27 93919 73176 64331610
Pericarditis 42.31 13.23 19 93927 62497 64342289
Dyspepsia 42.26 13.23 33 93913 80279 64324507
Exposure during pregnancy 42.04 13.23 31 93915 77644 64327142
Systemic lupus erythematosus 41.97 13.23 31 93915 77581 64327205
Foetal malposition 41.77 13.23 9 93937 13 64404773
Rash 41.66 13.23 447 93499 458102 63946684
Injection site bruising 41.38 13.23 3 93943 36370 64368416
Adenocarcinoma of colon 41.31 13.23 43 93903 4865 64399921
Dysstasia 41.19 13.23 99 93847 23116 64381670
Agranulocytosis 41.16 13.23 4 93942 38225 64366561
Medication error 41.01 13.23 11 93935 49955 64354831
Tremor 40.59 13.23 361 93585 147869 64256917
Abdominal distension 40.55 13.23 48 93898 95946 64308840
Blood pressure systolic increased 40.38 13.23 11 93935 49442 64355344
Viral infection 40.20 13.23 130 93816 36010 64368776
Basal cell carcinoma 39.96 13.23 117 93829 30721 64374065
Haemoptysis 39.88 13.23 11 93935 49037 64355749
Unevaluable event 39.81 13.23 12 93934 50477 64354309
White blood cell count increased 39.79 13.23 196 93750 65818 64338968
Blood urea increased 39.65 13.23 8 93938 44145 64360641
Oedema peripheral 39.35 13.23 165 93781 210152 64194634
Fibula fracture 39.28 13.23 34 93912 3054 64401732
Herpes simplex encephalitis 39.18 13.23 19 93927 622 64404164
Cardiac arrest 38.98 13.23 106 93840 153958 64250828
Pruritus allergic 38.74 13.23 21 93925 871 64403915
Marburg's variant multiple sclerosis 38.73 13.23 7 93939 0 64404786
Overdose 38.73 13.23 112 93834 159454 64245332
Abortion missed 38.53 13.23 23 93923 1149 64403637
Ophthalmic herpes zoster 38.28 13.23 29 93917 2155 64402631
Flushing 38.18 13.23 220 93726 78428 64326358
Clostridial infection 38.07 13.23 42 93904 5077 64399709
Concussion 37.75 13.23 52 93894 7886 64396900
Serotonin syndrome 37.70 13.23 6 93940 39276 64365510
Agitation 37.52 13.23 44 93902 88323 64316463
Hypokalaemia 37.12 13.23 76 93870 121827 64282959
Chronic kidney disease 37.06 13.23 19 93927 57900 64346886
Blister 36.93 13.23 38 93908 80929 64323857
Appendicectomy 36.32 13.23 28 93918 2135 64402651
Urostomy 36.24 13.23 7 93939 3 64404783
Osteonecrosis of jaw 36.22 13.23 7 93939 39818 64364968
Antibody test positive 35.78 13.23 29 93917 2378 64402408
Drug level increased 35.73 13.23 4 93942 34192 64370594
Pyelonephritis 35.45 13.23 78 93868 17188 64387598
Agraphia 35.37 13.23 9 93937 36 64404750
Ovarian cancer 35.22 13.23 33 93913 3286 64401500
Skin exfoliation 34.79 13.23 11 93935 44874 64359912
Constipation 34.73 13.23 194 93752 229143 64175643
Oedema 34.69 13.23 50 93896 91885 64312901
Sensory disturbance 34.61 13.23 66 93880 13142 64391644
Pneumonitis 34.57 13.23 15 93931 50350 64354436
Helicobacter infection 34.35 13.23 7 93939 38355 64366431
Hypervolaemia 34.25 13.23 7 93939 38278 64366508
Haematochezia 34.01 13.23 28 93918 66345 64338441
Hepatocellular injury 33.47 13.23 12 93934 45223 64359563
Arthropathy 33.08 13.23 80 93866 120887 64283899
Weight decreased 33.07 13.23 262 93684 285477 64119309
Cholestasis 33.03 13.23 12 93934 44860 64359926
Depression suicidal 33.01 13.23 28 93918 2447 64402339
Post procedural infection 32.97 13.23 54 93892 9543 64395243
Haematuria 32.90 13.23 24 93922 60447 64344339
Plasma cell myeloma 32.79 13.23 13 93933 46062 64358724
Hypocalcaemia 32.78 13.23 10 93936 41743 64363043
Band sensation 32.58 13.23 17 93929 652 64404134
Meningitis viral 32.52 13.23 24 93922 1714 64403072
Hyperhidrosis 32.31 13.23 85 93861 124835 64279951
Sopor 32.21 13.23 3 93943 29658 64375128
Hemianaesthesia 32.14 13.23 15 93931 450 64404336
Inappropriate schedule of product administration 32.13 13.23 53 93893 92233 64312553
Delirium 32.10 13.23 32 93914 69162 64335624
Hepatic function abnormal 31.89 13.23 28 93918 64285 64340501
Female genital operation 31.76 13.23 7 93939 12 64404774
Malignant melanoma in situ 31.53 13.23 24 93922 1796 64402990
Lung adenocarcinoma 31.36 13.23 44 93902 6789 64397997
Tubulointerstitial nephritis 31.35 13.23 4 93942 30905 64373881
Ventricular tachycardia 31.21 13.23 6 93940 34259 64370527
Depressed level of consciousness 31.01 13.23 44 93902 81392 64323394
Dry skin 30.96 13.23 18 93928 51143 64353643
Pneumonia aspiration 30.89 13.23 169 93777 59102 64345684
Immune system disorder 30.81 13.23 51 93895 9090 64395696
JC polyomavirus test 30.50 13.23 8 93938 37 64404749
Generalised tonic-clonic seizure 30.50 13.23 127 93819 39730 64365056
Arthropod bite 30.43 13.23 43 93903 6678 64398108
Shock 30.31 13.23 9 93937 38231 64366555
Drug resistance 30.22 13.23 7 93939 35095 64369691
Hyperglycaemia 29.68 13.23 27 93919 60941 64343845
Steroid therapy 29.51 13.23 8 93938 43 64404743
Red blood cell sedimentation rate increased 29.46 13.23 5 93941 31230 64373556
B-cell lymphoma 29.41 13.23 38 93908 5419 64399367
Wheezing 29.26 13.23 45 93901 80534 64324252
Bladder dysfunction 28.88 13.23 18 93928 972 64403814
Incontinence 28.78 13.23 58 93888 12023 64392763
Motor dysfunction 28.78 13.23 56 93890 11317 64393469
Restlessness 28.68 13.23 11 93935 39774 64365012
Neutralising antibodies 28.58 13.23 7 93939 23 64404763
Circulatory collapse 28.50 13.23 7 93939 33725 64371061
Partial seizures with secondary generalisation 28.33 13.23 14 93932 478 64404308
Coagulopathy 28.22 13.23 6 93940 31914 64372872
Arrested labour 28.20 13.23 10 93936 144 64404642
Meningoencephalitis herpetic 27.85 13.23 22 93924 1739 64403047
Feeling hot 27.82 13.23 136 93810 45527 64359259
Animal bite 27.73 13.23 24 93922 2155 64402631
Vaginal infection 27.68 13.23 35 93911 4885 64399901
Hypertension 27.60 13.23 243 93703 259018 64145768
Appendicitis 27.52 13.23 61 93885 13508 64391278
Hypomagnesaemia 27.51 13.23 10 93936 37366 64367420
Orthostatic hypotension 27.50 13.23 17 93929 46721 64358065
Sedation 27.44 13.23 13 93933 41449 64363337
Bladder catheterisation 27.40 13.23 16 93930 767 64404019
Neurogenic bowel 27.29 13.23 10 93936 159 64404627
Inflammation 27.20 13.23 33 93913 65267 64339519
Mammoplasty 27.20 13.23 11 93935 231 64404555
Anal incontinence 27.17 13.23 65 93881 15131 64389655
Proteinuria 27.14 13.23 4 93942 27719 64377067
Urinary tract disorder 27.12 13.23 28 93918 3138 64401648
Disseminated intravascular coagulation 26.78 13.23 7 93939 32341 64372445
Treatment noncompliance 26.74 13.23 15 93931 43467 64361319
Blood pressure fluctuation 26.43 13.23 22 93924 51849 64352937
Postoperative wound infection 26.29 13.23 51 93895 10285 64394501
Conversion disorder 26.17 13.23 21 93925 1698 64403088
Ear infection 25.86 13.23 84 93862 23320 64381466
Tachypnoea 25.63 13.23 4 93942 26567 64378219
Major depression 25.54 13.23 43 93903 7773 64397013
Haematemesis 25.12 13.23 19 93927 46980 64357806
Nasal congestion 25.01 13.23 30 93916 59628 64345158
Umbilical cord around neck 24.91 13.23 6 93940 18 64404768
Pneumocystis jirovecii pneumonia 24.83 13.23 5 93941 27629 64377157
Urinary tract infection staphylococcal 24.77 13.23 15 93931 769 64404017
Glioblastoma 24.73 13.23 19 93927 1442 64403344
Papilloma viral infection 24.69 13.23 19 93927 1445 64403341
Dry mouth 24.68 13.23 31 93915 60387 64344399
Cervix carcinoma stage III 24.66 13.23 6 93940 19 64404767
Haemorrhage 24.55 13.23 49 93897 79302 64325484
Thermal burn 24.14 13.23 36 93910 5870 64398916
Disease recurrence 23.93 13.23 8 93938 31502 64373284
Infectious mononucleosis 23.92 13.23 20 93926 1713 64403073
Flatulence 23.88 13.23 11 93935 35655 64369131
General physical health deterioration 23.84 13.23 187 93759 204238 64200548
Intrathecal pump insertion 23.73 13.23 5 93941 6 64404780
Incorrect route of product administration 23.66 13.23 3 93943 23295 64381491
Pulmonary hypertension 23.62 13.23 17 93929 43122 64361664
Obstructive airways disorder 23.51 13.23 3 93943 23182 64381604
Septic shock 23.45 13.23 77 93869 105360 64299426
Upper gastrointestinal haemorrhage 23.37 13.23 11 93935 35209 64369577
Infected skin ulcer 23.12 13.23 25 93921 2955 64401831
Medical device removal 23.11 13.23 13 93933 580 64404206
Paraparesis 23.10 13.23 27 93919 3475 64401311
Rebound effect 23.07 13.23 32 93914 4885 64399901
Bile acid malabsorption 23.04 13.23 9 93937 172 64404614
Vertigo 22.96 13.23 156 93790 58855 64345931
Myelitis transverse 22.96 13.23 19 93927 1604 64403182
Fluid retention 22.90 13.23 32 93914 59574 64345212
Ligament rupture 22.76 13.23 23 93923 2513 64402273
Palpitations 22.76 13.23 77 93869 104411 64300375
Blood potassium increased 22.73 13.23 5 93941 25975 64378811
Medical device change 22.67 13.23 12 93934 474 64404312
Faeces discoloured 22.41 13.23 5 93941 25724 64379062
Status epilepticus 22.37 13.23 76 93870 21587 64383199
Catheter placement 22.33 13.23 23 93923 2570 64402216
Pulmonary oedema 22.33 13.23 51 93895 78623 64326163
Ejection fraction decreased 22.31 13.23 7 93939 28700 64376086
Hypercalcaemia 22.13 13.23 9 93937 31407 64373379
Colon cancer metastatic 22.12 13.23 20 93926 1903 64402883
Paraesthesia 22.11 13.23 296 93650 134226 64270560
Gastrooesophageal reflux disease 21.93 13.23 56 93890 83087 64321699
Knee operation 21.89 13.23 30 93916 4527 64400259
Progressive relapsing multiple sclerosis 21.87 13.23 6 93940 34 64404752
Drug ineffective for unapproved indication 21.80 13.23 9 93937 31124 64373662
Poisoning 21.78 13.23 3 93943 21876 64382910
Frustration tolerance decreased 21.77 13.23 35 93911 6090 64398696
Ovarian mass 21.70 13.23 11 93935 397 64404389
Tumefactive multiple sclerosis 21.62 13.23 7 93939 75 64404711
Respiratory depression 21.57 13.23 4 93942 23439 64381347
Ataxia 21.52 13.23 76 93870 22008 64382778
Blood pressure increased 21.46 13.23 155 93791 172397 64232389
Goitre 21.32 13.23 31 93915 4942 64399844
Cervical spinal stenosis 21.20 13.23 20 93926 2009 64402777
H1N1 influenza 21.16 13.23 21 93925 2245 64402541
Calculus bladder 20.94 13.23 16 93930 1204 64403582
Blood lactate dehydrogenase increased 20.94 13.23 11 93935 33067 64371719
Cephalo-pelvic disproportion 20.87 13.23 8 93938 145 64404641
Oral pain 20.84 13.23 7 93939 27486 64377300
Cellulitis staphylococcal 20.82 13.23 15 93931 1032 64403754
Spondylitic myelopathy 20.78 13.23 6 93940 42 64404744
Foetal heart rate deceleration abnormality 20.75 13.23 7 93939 86 64404700
Angina pectoris 20.73 13.23 21 93925 45060 64359726
Infusion site haematoma 20.66 13.23 9 93937 229 64404557
Red blood cell count decreased 20.64 13.23 24 93922 48362 64356424
Therapeutic procedure 20.50 13.23 13 93933 724 64404062
Tooth infection 20.47 13.23 57 93889 14544 64390242
Multiple allergies 20.36 13.23 33 93913 5781 64399005
Colon cancer 20.15 13.23 52 93894 12687 64392099
Sleep disorder 20.13 13.23 35 93911 59674 64345112
Blood pressure diastolic decreased 20.11 13.23 4 93942 22297 64382489
Endometrial adenocarcinoma 20.03 13.23 14 93932 918 64403868
Herpes simplex meningitis 19.98 13.23 6 93940 49 64404737
Blindness 19.95 13.23 74 93872 21945 64382841
B-cell lymphoma stage I 19.90 13.23 4 93942 3 64404783
Ependymoma 19.77 13.23 6 93940 51 64404735
Drug dependence 19.76 13.23 12 93934 33300 64371486
Prescribed overdose 19.75 13.23 3 93943 20328 64384458
Fibroadenoma of breast 19.66 13.23 9 93937 258 64404528
Bladder repair 19.66 13.23 6 93940 52 64404734
Hip surgery 19.63 13.23 21 93925 2452 64402334
Procedural pain 19.29 13.23 58 93888 15450 64389336
Muscle tightness 19.29 13.23 47 93899 11068 64393718
Hyperemesis gravidarum 19.27 13.23 10 93936 379 64404407
Red blood cell nucleated morphology present 19.27 13.23 5 93941 22 64404764
Autoimmune hepatitis 18.97 13.23 44 93902 10040 64394746
Mouth ulceration 18.82 13.23 12 93934 32432 64372354
Plasmablastic lymphoma 18.80 13.23 10 93936 399 64404387
Post procedural complication 18.72 13.23 71 93875 21282 64383504
Pelvic fracture 18.69 13.23 45 93901 10518 64394268
Jaundice 18.68 13.23 26 93920 48486 64356300
Squamous cell carcinoma of the cervix 18.57 13.23 8 93938 198 64404588
Pericardial effusion 18.38 13.23 18 93928 39236 64365550
Mammogram abnormal 18.29 13.23 10 93936 422 64404364
Gastrointestinal viral infection 18.24 13.23 14 93932 1061 64403725
Ventricular fibrillation 18.22 13.23 6 93940 23854 64380932
Back injury 18.19 13.23 37 93909 7720 64397066
CD4 lymphocytes decreased 18.14 13.23 20 93926 2415 64402371
Osteomyelitis 18.13 13.23 84 93862 27503 64377283
Respiratory failure 18.07 13.23 149 93797 161034 64243752
Intervertebral disc operation 18.03 13.23 12 93934 726 64404060
Cardiomegaly 18.01 13.23 6 93940 23678 64381108
Rash erythematous 17.80 13.23 27 93919 48606 64356180
Withdrawal syndrome 17.78 13.23 6 93940 23486 64381300
Latent tuberculosis 17.76 13.23 21 93925 2736 64402050
Herpes zoster meningitis 17.67 13.23 7 93939 139 64404647
Human papilloma virus test positive 17.60 13.23 10 93936 455 64404331
Aggression 17.58 13.23 25 93921 46207 64358579
Lung adenocarcinoma stage IV 17.52 13.23 8 93938 228 64404558
Spinal fusion surgery 17.49 13.23 24 93922 3627 64401159
Bladder operation 17.48 13.23 12 93934 764 64404022
Pulmonary fibrosis 17.40 13.23 11 93935 29867 64374919
Respiratory distress 17.34 13.23 31 93915 52300 64352486
Hepatic failure 17.31 13.23 34 93912 55360 64349426
Herpes zoster infection neurological 17.27 13.23 7 93939 148 64404638
Dysphemia 17.25 13.23 22 93924 3097 64401689
Blood alkaline phosphatase increased 17.20 13.23 35 93911 56244 64348542
Heat exhaustion 17.14 13.23 8 93938 240 64404546
Infusion site hypersensitivity 17.14 13.23 4 93942 10 64404776
Abdominoplasty 17.08 13.23 5 93941 37 64404749
Precancerous cells present 16.90 13.23 13 93933 988 64403798
Imminent abortion 16.86 13.23 4 93942 11 64404775
Blindness unilateral 16.76 13.23 33 93913 6728 64398058
Gastric banding 16.74 13.23 5 93941 40 64404746
Transfusion 16.71 13.23 3 93943 17991 64386795
Urethral valves 16.60 13.23 3 93943 0 64404786
Alcoholic seizure 16.60 13.23 3 93943 0 64404786
Intracranial haemangioma 16.60 13.23 3 93943 0 64404786
Gestational oedema 16.60 13.23 3 93943 0 64404786
Magnetic resonance imaging head abnormal 16.59 13.23 19 93927 2393 64402393
Endometrial cancer 16.55 13.23 17 93929 1893 64402893
Abortion 16.52 13.23 14 93932 1222 64403564
Respiratory tract infection 16.46 13.23 102 93844 37305 64367481
Neurological symptom 16.41 13.23 33 93913 6831 64397955
Cholelithiasis 16.36 13.23 118 93828 45388 64359398
Hypoalbuminaemia 16.30 13.23 3 93943 17671 64387115
Folliculitis 16.28 13.23 12 93934 30065 64374721
HIV test positive 16.23 13.23 6 93940 98 64404688
Female reproductive tract disorder 16.22 13.23 8 93938 272 64404514
Acute myocardial infarction 16.14 13.23 50 93896 69668 64335118
Rhinorrhoea 16.12 13.23 40 93906 59929 64344857
Arrhythmia 16.12 13.23 33 93913 52911 64351875
Fibromyalgia 16.03 13.23 17 93929 35714 64369072
Back disorder 16.03 13.23 41 93905 9949 64394837
Face oedema 16.02 13.23 8 93938 24753 64380033
Wound sepsis 15.96 13.23 7 93939 181 64404605
Product administered to patient of inappropriate age 15.95 13.23 26 93920 4575 64400211
Ligament sprain 15.84 13.23 43 93903 10809 64393977
Breast cyst 15.81 13.23 13 93933 1088 64403698
Hepatotoxicity 15.81 13.23 21 93925 39941 64364845
Pineal gland cyst 15.72 13.23 4 93942 16 64404770
Lung cancer metastatic 15.58 13.23 21 93925 3119 64401667
Dysgeusia 15.48 13.23 28 93918 47019 64357767
Patella fracture 15.44 13.23 15 93931 1563 64403223
Leukocytosis 15.42 13.23 101 93845 37639 64367147
Dysarthria 15.39 13.23 143 93803 59263 64345523
Glioblastoma multiforme 15.37 13.23 13 93933 1131 64403655
Drug eruption 15.33 13.23 18 93928 36118 64368668
Demyelination 15.33 13.23 32 93914 6802 64397984
Melanocytic naevus 15.27 13.23 24 93922 4096 64400690
Pneumonia 15.26 13.23 977 92969 558599 63846187
Foetal distress syndrome 15.20 13.23 9 93937 443 64404343
Dry eye 15.16 13.23 12 93934 29007 64375779
Myelitis 15.13 13.23 17 93929 2097 64402689
Feeling abnormal 15.09 13.23 276 93670 133326 64271460
Osteonecrosis 15.05 13.23 81 93865 28148 64376638
Cardiogenic shock 15.03 13.23 15 93931 32412 64372374
Vitamin D decreased 14.97 13.23 34 93912 7653 64397133
Tenderness 14.84 13.23 5 93941 19597 64385189
Neurofibroma 14.83 13.23 4 93942 21 64404765
Cerebral infarction 14.82 13.23 23 93923 41021 64363765
Expanded disability status scale score increased 14.80 13.23 9 93937 465 64404321
Urine output decreased 14.78 13.23 3 93943 16489 64388297
Vaccination complication 14.78 13.23 10 93936 622 64404164
Foetal heart rate decreased 14.68 13.23 4 93942 22 64404764
Panic attack 14.67 13.23 65 93881 20888 64383898
Nodule 14.64 13.23 4 93942 17943 64386843
Pertussis 14.61 13.23 11 93935 810 64403976
Cerebral haemorrhage 14.59 13.23 33 93913 51057 64353729
Pain in jaw 14.56 13.23 23 93923 40732 64364054
JC virus infection 14.51 13.23 21 93925 3334 64401452
Blepharospasm 14.41 13.23 21 93925 3354 64401432
Ileostomy closure 14.33 13.23 6 93940 138 64404648
Myocardial ischaemia 14.33 13.23 8 93938 23243 64381543
Device malfunction 14.25 13.23 4 93942 17629 64387157
Abdominal pain upper 14.13 13.23 175 93771 174855 64229931
Vibratory sense increased 14.11 13.23 4 93942 26 64404760
Micturition urgency 14.09 13.23 40 93906 10319 64394467
Lumbar radiculopathy 14.09 13.23 15 93931 1742 64403044
Device extrusion 13.98 13.23 4 93942 27 64404759
Astrocytoma malignant 13.98 13.23 4 93942 27 64404759
Oral infection 13.93 13.23 25 93921 4752 64400034
Sinus bradycardia 13.93 13.23 8 93938 22885 64381901
Foetal heart rate abnormal 13.90 13.23 7 93939 249 64404537
Blindness transient 13.90 13.23 23 93923 4099 64400687
Skull fracture 13.87 13.23 14 93932 1527 64403259
Lumbar puncture 13.80 13.23 6 93940 152 64404634
Automatic bladder 13.79 13.23 5 93941 77 64404709
Platelet count increased 13.76 13.23 5 93941 18691 64386095
Gout 13.73 13.23 7 93939 21406 64383380
Metabolic surgery 13.72 13.23 11 93935 888 64403898
Anembryonic gestation 13.71 13.23 8 93938 383 64404403
Sinus tachycardia 13.69 13.23 16 93930 32172 64372614
Colectomy 13.66 13.23 18 93928 2616 64402170
Haemorrhage intracranial 13.62 13.23 9 93937 23875 64380911
Benign neoplasm 13.58 13.23 11 93935 901 64403885
Haematocrit decreased 13.52 13.23 38 93908 54617 64350169
Ovarian cyst 13.51 13.23 41 93905 10977 64393809
Hyperbilirubinaemia 13.50 13.23 7 93939 21198 64383588
Eczema 13.49 13.23 14 93932 29706 64375080
Nerve compression 13.43 13.23 32 93914 7429 64397357
Clumsiness 13.36 13.23 18 93928 2673 64402113
Diplegia 13.35 13.23 14 93932 1597 64403189
Blood albumin decreased 13.35 13.23 7 93939 21066 64383720
Breast reconstruction 13.34 13.23 5 93941 85 64404701
Gastrointestinal procedural complication 13.34 13.23 5 93941 85 64404701
Abdominal adhesions 13.34 13.23 19 93927 2973 64401813
Frequent bowel movements 13.30 13.23 5 93941 18300 64386486
Ovarian cystectomy 13.28 13.23 5 93941 86 64404700
Drowning 13.25 13.23 10 93936 739 64404047

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA23 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
MeSH PA D007155 Immunologic Factors
FDA MoA N0000175774 Integrin Receptor Antagonists
FDA EPC N0000175775 Integrin Receptor Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Multiple sclerosis indication 24700007 DOID:2377
Crohn's disease indication 34000006
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Integrin alpha-4/beta-1 Adhesion ANTIBODY BINDING DRUG LABEL DRUG LABEL
Integrin alpha-4/beta-7 Adhesion ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D06886 KEGG_DRUG
4021508 VUID
N0000148870 NUI
4021508 VANDF
CHEMBL1201607 ChEMBL_ID
6591 IUPHAR_LIGAND_ID
7716 INN_ID
DB00108 DRUGBANK_ID
3JB47N2Q2P UNII
354770 RXNORM
19083 MMSL
63826 MMSL
d05414 MMSL
414804006 SNOMEDCT_US
414805007 SNOMEDCT_US
D000069442 MESH_DESCRIPTOR_UI
C1172734 UMLSCUI
008765 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TYSABRI HUMAN PRESCRIPTION DRUG LABEL 1 64406-008 INJECTION 300 mg INTRAVENOUS BLA 30 sections