efalizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4959 214745-43-4

Description:

MoleculeDescription

Synonyms:

  • efalizumab
  • raptiva
  • hu1124
  • anti-CD11a
  • xanelim
a humanized anti-CD11anti-adhesion monoclonal antibody
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 20, 2004 EMA
Oct. 27, 2003 FDA GENENTECH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Psoriasis 80.67 75.13 26 306 86931 63401759

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA21 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
FDA CS M0001357 Antibodies, Monoclonal
FDA MoA N0000175856 CD11a-directed Antibody Interactions
FDA EPC N0000175858 CD11a-directed Humanized IgG1 Antibody

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Plaque psoriasis indication 200965009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Leukocyte adhesion glycoprotein LFA-1 alpha Adhesion ANTIBODY BINDING Kd 11.40 IUPHAR DRUG LABEL

External reference:

IDSource
D03959 KEGG_DRUG
4021411 VUID
N0000148826 NUI
4021411 VANDF
CHEMBL1201575 ChEMBL_ID
C472181 MESH_SUPPLEMENTAL_RECORD_UI
6593 IUPHAR_LIGAND_ID
DB00095 DRUGBANK_ID
356988 RXNORM
17649 MMSL
47678 MMSL
d04902 MMSL
005208 NDDF
407005009 SNOMEDCT_US
407006005 SNOMEDCT_US
C1174995 UMLSCUI
8122 INN_ID
XX2MN88N5D UNII

Pharmaceutical products:

None