muromonab-CD3 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
cannabinoid receptors agonists	5177	140608-64-6

Description:

Molecule	Description
Synonyms: muromonab-CD3 orthoclone OKT3	a murine monoclonal antibody to the CD3 antigen of human T cells which functions as an immunosuppressant Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

muromonab-CD3
orthoclone OKT3

a murine monoclonal antibody to the CD3 antigen of human T cells which functions as an immunosuppressant

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
5	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 14, 1992	FDA	ORTHO BIOTECH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Post transplant lymphoproliferative disorder	80.39	68.68	16	262	11448	79732662

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	L04AA02	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Selective immunosuppressants
FDA EPC	N0000175620	CD3 Blocker Immunosuppressant
FDA MoA	N0000175617	CD3-directed Antibody Interactions
FDA MoA	N0000175619	CD3 Receptor Antagonists
FDA PE	N0000175550	Decreased Immunologic Activity
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Renal transplant rejection	indication	236570004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
T-cell surface glycoprotein CD3	Surface antigen	P07766 P09693 P04234	CD3E_HUMAN CD3G_HUMAN CD3D_HUMAN	ANTIBODY BINDING				UNKNOWN	IUPHAR

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External reference:

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ID	Source
003421	NDDF
109137000	SNOMEDCT_US
227302	RXNORM
3838	MMSL
4018561	VANDF
412251003	SNOMEDCT_US
5140	MMSL
6281	INN_ID
6889	IUPHAR_LIGAND_ID
C0085379	UMLSCUI

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Pharmaceutical products:

None