muromonab-CD3 Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5177 140608-64-6

Description:

MoleculeDescription

Synonyms:

  • muromonab-CD3
  • orthoclone OKT3
a murine monoclonal antibody to the CD3 antigen of human T cells which functions as an immunosuppressant
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
5 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 14, 1992 FDA ORTHO BIOTECH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
FDA PE N0000175550 Decreased Immunologic Activity
FDA MoA N0000175617 CD3-directed Antibody Interactions
FDA MoA N0000175619 CD3 Receptor Antagonists
FDA EPC N0000175620 CD3 Blocker Immunosuppressant
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Renal transplant rejection indication 236570004

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
T-cell surface glycoprotein CD3 Surface antigen ANTIBODY BINDING UNKNOWN IUPHAR

External reference:

IDSource
4018561 VANDF
C0085379 UMLSCUI
D05092 KEGG_DRUG
CHEMBL1201608 ChEMBL_ID
D016853 MESH_DESCRIPTOR_UI
DB00075 DRUGBANK_ID
6889 IUPHAR_LIGAND_ID
6281 INN_ID
JGA39ICE2V UNII
227302 RXNORM
3838 MMSL
5140 MMSL
d03118 MMSL
003421 NDDF
109137000 SNOMEDCT_US
412251003 SNOMEDCT_US

Pharmaceutical products:

None