imidafenacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
muscarinic receptors antagonists 4902 170105-16-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • imidafenacin
  • uritos
  • KRP-197
  • KRP 197
  • Molecular weight: 319.41
  • Formula: C20H21N3O
  • CLOGP: 2.23
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 60.91
  • ALOGS: -4.53
  • ROTB: 6

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 1.51 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 18, 2007 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bladder muscle dysfunction - overactive indication 236633002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.68 acidic
pKa2 6.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Kb 9.50 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Muscarinic acetylcholine receptor M1 GPCR Kb 8.38 SCIENTIFIC LITERATURE

External reference:

IDSource
XJR8Y07LJO UNII
D06273 KEGG_DRUG
C1876226 UMLSCUI
CHEBI:134720 CHEBI
CHEMBL53366 ChEMBL_ID
6433090 PUBCHEM_CID
DB09262 DRUGBANK_ID
8402 INN_ID
C120953 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None