flavoxate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1175	15301-69-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: urispas flavoxate flavoxate hydrochloride flavoxate HCl	A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. Molecular weight: 391.47 Formula: C24H25NO4 CLOGP: 4.97 LIPINSKI: 0 HAC: 5 HDO: 0 TPSA: 55.84 ALOGS: -4.41 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

urispas
flavoxate
flavoxate hydrochloride
flavoxate HCl

A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist.

Molecular weight: 391.47
Formula: C24H25NO4
CLOGP: 4.97
LIPINSKI: 0
HAC: 5
HDO: 0
TPSA: 55.84
ALOGS: -4.41
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.80	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Hosey CM, Chan R, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Jan. 15, 1970	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

Source	Code	Description
ATC	G04BD02	GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Drugs for urinary frequency and incontinence
FDA EPC	N0000175700	Cholinergic Muscarinic Antagonist
FDA MoA	N0000000125	Cholinergic Muscarinic Antagonists
MeSH PA	D010276	Parasympatholytics
MeSH PA	D018373	Peripheral Nervous System Agents
CHEBI has role	CHEBI:50370	parasympatholytic
CHEBI has role	CHEBI:48876	muscarinic antagonist
CHEBI has role	CHEBI:53784	antispasmodic drug
MeSH PA	D064804	Urological Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Dysuria	indication	49650001
Urgent desire to urinate	indication	75088002
Nocturia	indication	139394000
Suprapubic pain	indication	162053006
Urinary incontinence	indication	165232002
Urinary Tract Irritation	indication
Increased Urinary Frequency	indication
Urinary tract obstruction	contraindication	7163005	DOID:5200
Paralytic ileus	contraindication	55525008	DOID:8442
Gastrointestinal hemorrhage	contraindication	74474003
Gastrointestinal obstruction	contraindication	126765001
Pyloric obstruction	contraindication	244815007
Angle-closure glaucoma	contraindication	392291006	DOID:13550

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.69	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Phosphodiesterase 4	Enzyme	P27815 Q07343 Q08493 Q08499	PDE4A_HUMAN PDE4B_HUMAN PDE4C_HUMAN PDE4D_HUMAN	INHIBITOR			CHEMBL	CHEMBL
Phosphodiesterase 7	Enzyme	Q13946 Q9NP56	PDE7A_HUMAN PDE7B_HUMAN	INHIBITOR			CHEMBL	CHEMBL
Phosphodiesterase 8	Enzyme	O60658 O95263	PDE8A_HUMAN PDE8B_HUMAN	INHIBITOR			CHEMBL	CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		Ki	4.70	DRUG MATRIX

External reference:

ID	Source
D005422	MESH_DESCRIPTOR_UI
4019756	VUID
N0000147847	NUI
C0016225	UMLSCUI
D00718	KEGG_DRUG
3E74Y80MEY	UNII
1929	INN_ID
53641000	SNOMEDCT_US
4440	RXNORM
372768002	SNOMEDCT_US
4019756	VANDF
d01425	MMSL
004714	NDDF
3717-88-2	SECONDARY_CAS_RN
CHEMBL1493	ChEMBL_ID
DB01148	DRUGBANK_ID
CHEBI:5088	CHEBI
CHEMBL1200875	ChEMBL_ID
3354	PUBCHEM_CID
7187	IUPHAR_LIGAND_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
FLAVOXATE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0574-0115	TABLET, FILM COATED	100 mg	ORAL	ANDA	12 sections
Flavoxate Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	24658-720	TABLET	100 mg	ORAL	ANDA	11 sections
Flavoxate Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	42806-058	TABLET	100 mg	ORAL	ANDA	11 sections
Flavoxate Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50268-324	TABLET	100 mg	ORAL	ANDA	11 sections
Flavoxate Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	54868-6326	TABLET, FILM COATED	100 mg	ORAL	ANDA	12 sections
FLAVOXATE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	68151-3826	TABLET, FILM COATED	100 mg	ORAL	ANDA	12 sections