flavoxate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1175 15301-69-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • urispas
  • flavoxate
  • flavoxate hydrochloride
  • flavoxate HCl
A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist.
  • Molecular weight: 391.47
  • Formula: C24H25NO4
  • CLOGP: 4.97
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 55.84
  • ALOGS: -4.41
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.80 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Jan. 15, 1970 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC G04BD02 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Drugs for urinary frequency and incontinence
FDA EPC N0000175700 Cholinergic Muscarinic Antagonist
FDA MoA N0000000125 Cholinergic Muscarinic Antagonists
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:50370 parasympatholytic
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:53784 antispasmodic drug
MeSH PA D064804 Urological Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dysuria indication 49650001
Urgent desire to urinate indication 75088002
Nocturia indication 139394000
Suprapubic pain indication 162053006
Urinary incontinence indication 165232002
Urinary Tract Irritation indication
Increased Urinary Frequency indication
Urinary tract obstruction contraindication 7163005 DOID:5200
Paralytic ileus contraindication 55525008 DOID:8442
Gastrointestinal hemorrhage contraindication 74474003
Gastrointestinal obstruction contraindication 126765001
Pyloric obstruction contraindication 244815007
Angle-closure glaucoma contraindication 392291006 DOID:13550

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.69 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Phosphodiesterase 4 Enzyme INHIBITOR CHEMBL CHEMBL
Phosphodiesterase 7 Enzyme INHIBITOR CHEMBL CHEMBL
Phosphodiesterase 8 Enzyme INHIBITOR CHEMBL CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 4.70 DRUG MATRIX

External reference:

IDSource
D005422 MESH_DESCRIPTOR_UI
4019756 VUID
N0000147847 NUI
C0016225 UMLSCUI
D00718 KEGG_DRUG
3E74Y80MEY UNII
1929 INN_ID
53641000 SNOMEDCT_US
4440 RXNORM
372768002 SNOMEDCT_US
4019756 VANDF
d01425 MMSL
004714 NDDF
3717-88-2 SECONDARY_CAS_RN
CHEMBL1493 ChEMBL_ID
DB01148 DRUGBANK_ID
CHEBI:5088 CHEBI
CHEMBL1200875 ChEMBL_ID
3354 PUBCHEM_CID
7187 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FLAVOXATE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0574-0115 TABLET, FILM COATED 100 mg ORAL ANDA 12 sections
Flavoxate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 24658-720 TABLET 100 mg ORAL ANDA 11 sections
Flavoxate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42806-058 TABLET 100 mg ORAL ANDA 11 sections
Flavoxate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-324 TABLET 100 mg ORAL ANDA 11 sections
Flavoxate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-6326 TABLET, FILM COATED 100 mg ORAL ANDA 12 sections
FLAVOXATE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 68151-3826 TABLET, FILM COATED 100 mg ORAL ANDA 12 sections