meladrazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3756 13957-36-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • meladrazine tartrate
  • hydramitrazine
  • meladrazine
  • Molecular weight: 253.35
  • Formula: C11H23N7
  • CLOGP: 3.36
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 83.20
  • ALOGS: -2.70
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.45 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK19,CDK5,CDK7,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IRAK1,ITK,JAK1,JAK2,KIT,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK1,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 69
kinase-selectivity-class AXL,BRAF,CDK16,CDK3,CDK7,CDK9,CLK4,DYRK1B,EPHB4,GRK2,MAP2K6,MAP3K21,MAPK12,MAPK7,SIK2,STK33,TEK,TTK 18
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G04BD03 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Drugs for urinary frequency and incontinence

Related Drugs by ATC class:

G04BD Drugs for urinary frequency and incontinence 13 drugs
darifenacinemeproniumfesoterodineflavoxateimidafenacinmirabegronoxybutyninpropiverinesolifenacinterodilinetolterodinetrospium show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.99 Basic
pKa2 4.9 Basic
pKa3 3.39 Basic
pKa4 0.68 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07225 KEGG_DRUG
20423-87-4 SECONDARY_CAS_RN
C0065895 UMLSCUI
CHEMBL2105242 ChEMBL_ID
DB13272 DRUGBANK_ID
C005040 MESH_SUPPLEMENTAL_RECORD_UI
1798 INN_ID
2V6Z0JG2X0 UNII
71679 PUBCHEM_CID
CHEBI:135034 CHEBI

Pharmaceutical products:

None