thioctic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4732 | 1077-28-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.60 | g | O |
| 0.60 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 29 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.10 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 11.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.21 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A16AX01 | ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Various alimentary tract and metabolism products |
| MeSH PA | D000975 | Antioxidants |
| MeSH PA | D018977 | Micronutrients |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D014803 | Vitamin B Complex |
| MeSH PA | D014815 | Vitamins |
| CHEBI has role | CHEBI:78675 | fundamental metabolites |
| CHEBI has role | CHEBI:176497 | geroprotectors |
| CHEBI has role | CHEBI:23357 | cofactor |
| CHEBI has role | CHEBI:26348 | prosthetic groups |
| CHEBI has role | CHEBI:50733 | Dietary Supplement |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diabetic peripheral neuropathy | indication | 424736006 | |
| Obstruction of bile duct | contraindication | 30144000 | |
| Low blood pressure | contraindication | 45007003 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.05 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | Enzyme | IC50 | 9 | CHEMBL | |||||
| SUMO-activating enzyme | Enzyme | IC50 | 5.32 | CHEMBL | |||||
| TAR DNA-binding protein 43 | Unclassified | IC50 | 4.70 | CHEMBL | |||||
| Bifunctional protein GlmU | Enzyme | IC50 | 5.41 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00086 | KEGG_DRUG |
| 4021484 | VUID |
| N0000148863 | NUI |
| 4021443 | VANDF |
| 4021484 | VANDF |
| CHEBI:30314 | CHEBI |
| LPA | PDB_CHEM_ID |
| CHEMBL33864 | ChEMBL_ID |
| CHEMBL134342 | ChEMBL_ID |
| 4822 | IUPHAR_LIGAND_ID |
| DB00166 | DRUGBANK_ID |
| 6417 | RXNORM |
| 107951 | MMSL |
| 23416 | MMSL |
| NOCODE | MMSL |
| d06655 | MMSL |
| 006470 | NDDF |
| 70496003 | SNOMEDCT_US |
| 715405004 | SNOMEDCT_US |
| C0023791 | UMLSCUI |
| D008063 | MESH_DESCRIPTOR_UI |
| 864 | PUBCHEM_CID |
| 73Y7P0K73Y | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Strovite One Caplets | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0642-0207 | TABLET | 15 mg | ORAL | UNAPPROVED DRUG OTHER | 14 sections |
| Strovite One Caplets | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0642-0207 | TABLET | 15 mg | ORAL | UNAPPROVED DRUG OTHER | 14 sections |
| Organdrainex | HUMAN OTC DRUG LABEL | 13 | 44911-0457 | LIQUID | 12 [hp_X] | ORAL | unapproved drug other | 9 sections |
| Vita-Rx Diabetic Vitamin | HUMAN PRESCRIPTION DRUG LABEL | 14 | 65121-301 | CAPSULE, GELATIN COATED | 150 mg | ORAL | unapproved drug other | 5 sections |
| Vita-Rx Diabetic Vitamin | HUMAN PRESCRIPTION DRUG LABEL | 14 | 69677-050 | CAPSULE, GELATIN COATED | 150 mg | ORAL | unapproved drug other | 5 sections |