All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

metamizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory analgesics, phenylbutazone derivatives	4659	68-89-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: algocalmin metamizole metamizole sodium metamizol metapyrin methampyrone dipyrone dipyrone monohydrate sulpyrine metamizole magnesium metamizole calcium	A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Molecular weight: 311.36 Formula: C13H17N3O4S CLOGP: -1.20 LIPINSKI: 0 HAC: 7 HDO: 1 TPSA: 81.16 ALOGS: -2.09 ROTB: 4

Drug dosage:

Dose	Unit	Route
3	g	O
3	g	P
3	g	R

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1257.61	12.35	967	37974	141467	50424716
Product prescribing error	490.88	12.35	264	38677	20697	50545486
Haematochezia	297.31	12.35	246	38695	39636	50526547
Agranulocytosis	267.13	12.35	180	38761	21241	50544942
Anaemia	217.23	12.35	549	38392	251907	50314276
Product monitoring error	208.77	12.35	79	38862	2685	50563498
Drug ineffective	191.91	12.35	210	38731	819123	49747060
Fracture	185.25	12.35	131	38810	16702	50549481
Systemic infection	178.77	12.35	67	38874	2216	50563967
Polyneuropathy	146.58	12.35	100	38841	12031	50554152
Haematemesis	133.72	12.35	134	38807	27591	50538592
Aspirin-exacerbated respiratory disease	132.34	12.35	42	38899	832	50565351
Fall	123.45	12.35	547	38394	334385	50231798
Joint swelling	113.56	12.35	25	38916	245261	50320922
Product dose omission issue	105.19	12.35	10	38931	183828	50382355
Abdominal pain lower	97.35	12.35	101	38840	21655	50544528
Leukopenia	95.81	12.35	180	38761	67348	50498835
Pallor	91.98	12.35	101	38840	23098	50543085
Labelled drug-drug interaction medication error	91.57	12.35	71	38870	10406	50555777
Abdominal discomfort	86.54	12.35	35	38906	231606	50334577
Systemic lupus erythematosus	84.99	12.35	6	38935	140616	50425567
Product administration error	83.77	12.35	89	38852	19610	50546573
Infusion related reaction	83.20	12.35	15	38926	169542	50396641
Synovitis	82.05	12.35	3	38938	123862	50442321
Apathy	81.31	12.35	58	38883	7490	50558693
Abdominal pain	78.81	12.35	375	38566	235853	50330330
Toxic epidermal necrolysis	77.40	12.35	88	38853	20904	50545279
Treatment failure	77.37	12.35	8	38933	137629	50428554
Restlessness	77.10	12.35	96	38845	25077	50541106
Pemphigus	76.01	12.35	4	38937	120162	50446021
Dyspnoea	74.60	12.35	694	38247	546914	50019269
Stevens-Johnson syndrome	73.20	12.35	87	38854	21665	50544518
Erysipelas	71.70	12.35	51	38890	6557	50559626
Therapeutic product effect decreased	69.02	12.35	11	38930	136039	50430144
Vomiting	68.86	12.35	596	38345	460162	50106021
Drug-induced liver injury	68.80	12.35	96	38845	27999	50538184
Sinusitis	68.34	12.35	23	38918	170535	50395648
Drug intolerance	65.70	12.35	44	38897	219060	50347123
Swelling	64.85	12.35	37	38904	200835	50365348
Drug hypersensitivity	64.42	12.35	59	38882	250951	50315232
Abdominal pain upper	61.36	12.35	264	38677	159045	50407138
Nausea	61.26	12.35	818	38123	704580	49861603
Arrhythmia	59.52	12.35	98	38843	33034	50533149
Arthropathy	58.71	12.35	24	38917	157882	50408301
Tachypnoea	58.71	12.35	64	38877	14513	50551670
Completed suicide	57.91	12.35	15	38926	131874	50434309
Jaundice	55.53	12.35	84	38857	26345	50539838
Lower respiratory tract infection	54.90	12.35	5	38936	95196	50470987
Malaise	54.62	12.35	110	38831	335422	50230761
Electrolyte imbalance	53.41	12.35	66	38875	17103	50549080
Alopecia	51.40	12.35	68	38873	244979	50321204
Drug interaction	51.37	12.35	295	38646	199326	50366857
Rheumatoid arthritis	49.16	12.35	50	38891	202500	50363683
Pericarditis	48.58	12.35	3	38938	78686	50487497
Haematoma	47.89	12.35	85	38856	30425	50535758
Pyrexia	47.70	12.35	474	38467	379729	50186454
Osteochondrosis	47.40	12.35	21	38920	1073	50565110
Pancytopenia	46.16	12.35	156	38785	83874	50482309
Gamma-glutamyltransferase increased	45.81	12.35	82	38859	29541	50536642
Nasal disorder	45.56	12.35	26	38915	2282	50563901
Maternal exposure during pregnancy	45.35	12.35	34	38907	159744	50406439
Disturbance in attention	45.28	12.35	84	38857	31102	50535081
Tachycardia	44.45	12.35	173	38768	99590	50466593
Malignant neoplasm progression	44.27	12.35	134	38807	67990	50498193
Stenosis	42.71	12.35	20	38921	1163	50565020
Hepatorenal failure	41.11	12.35	16	38925	587	50565596
Oedema peripheral	40.98	12.35	234	38707	157727	50408456
Reduced facial expression	39.88	12.35	21	38920	1573	50564610
Syncope	39.86	12.35	171	38770	102831	50463352
Acute hepatic failure	39.02	12.35	54	38887	15623	50550560
Medication error	39.00	12.35	86	38855	36018	50530165
Nasopharyngitis	38.96	12.35	55	38886	192872	50373311
Product use issue	38.46	12.35	35	38906	149440	50416743
Musculoskeletal stiffness	38.21	12.35	26	38915	128455	50437728
Arthralgia	37.51	12.35	192	38749	438510	50127673
Ascites	37.14	12.35	84	38857	35777	50530406
Listless	36.95	12.35	23	38918	2367	50563816
Cardiac failure	36.45	12.35	135	38806	75905	50490278
Injection site pain	36.45	12.35	20	38921	111004	50455179
Subileus	36.33	12.35	24	38917	2735	50563448
Hypokalaemia	36.31	12.35	149	38792	87843	50478340
Cardiac failure congestive	36.26	12.35	10	38931	84372	50481811
Renal impairment	36.00	12.35	134	38807	75527	50490656
Somatic symptom disorder	35.98	12.35	21	38920	1923	50564260
Tumour pain	35.97	12.35	18	38923	1212	50564971
Hepatitis toxic	35.89	12.35	24	38917	2792	50563391
Suspected product quality issue	35.85	12.35	11	38930	194	50565989
Musculoskeletal pain	35.32	12.35	129	38812	72048	50494135
Concomitant disease aggravated	35.18	12.35	37	38904	8054	50558129
Gallbladder polyp	35.02	12.35	15	38926	706	50565477
Rash	34.34	12.35	197	38744	437274	50128909
Constipation	34.01	12.35	252	38689	185456	50380727
Urogenital haemorrhage	33.97	12.35	11	38930	233	50565950
Atrial fibrillation	33.45	12.35	161	38780	101584	50464599
Dysuria	33.20	12.35	70	38871	28434	50537749
Dehydration	32.68	12.35	215	38726	152234	50413949
Dizziness	32.08	12.35	407	38534	345962	50220221
Therapeutic drug monitoring analysis not performed	32.05	12.35	14	38927	691	50565492
Facial nerve disorder	32.04	12.35	13	38928	533	50565650
Type I hypersensitivity	32.02	12.35	21	38920	2364	50563819
Angina pectoris	31.30	12.35	65	38876	26123	50540060
Weight increased	31.27	12.35	68	38873	201823	50364360
Spinal pain	31.17	12.35	40	38901	10763	50555420
Bicytopenia	30.86	12.35	19	38922	1917	50564266
Gastrointestinal sounds abnormal	30.40	12.35	24	38917	3610	50562573
Headache	29.00	12.35	250	38691	506285	50059898
Nasal congestion	28.63	12.35	3	38938	51117	50515066
Respiratory alkalosis	28.62	12.35	20	38921	2499	50563684
Contraindicated product administered	28.56	12.35	44	38897	148914	50417269
Thrombocytopenia	28.55	12.35	182	38759	127491	50438692
Thirst	28.50	12.35	38	38903	10612	50555571
Injection site erythema	28.47	12.35	11	38930	74925	50491258
Faecaloma	28.26	12.35	31	38910	7077	50559106
Therapeutic product effect incomplete	27.90	12.35	18	38923	91497	50474686
Cachexia	27.73	12.35	25	38916	4508	50561675
Delirium	27.55	12.35	78	38863	38114	50528069
Muscle tone disorder	27.09	12.35	8	38933	123	50566060
Upper gastrointestinal haemorrhage	26.88	12.35	46	38895	15989	50550194
Nail toxicity	26.70	12.35	10	38931	330	50565853
Antineutrophil cytoplasmic antibody positive	26.04	12.35	11	38930	500	50565683
Discomfort	25.99	12.35	27	38914	108353	50457830
Post-traumatic pain	25.72	12.35	10	38931	366	50565817
Thirst decreased	25.66	12.35	9	38932	245	50565938
Acute generalised exanthematous pustulosis	25.64	12.35	33	38908	8905	50557278
Drug reaction with eosinophilia and systemic symptoms	25.54	12.35	63	38878	28361	50537822
Immobile	25.41	12.35	25	38916	5029	50561154
Prescription drug used without a prescription	25.37	12.35	16	38925	1684	50564499
Vascular encephalopathy	25.36	12.35	10	38931	380	50565803
Hepatic failure	25.34	12.35	68	38873	32215	50533968
Helicobacter infection	25.23	12.35	4	38937	49698	50516485
Ileus	24.93	12.35	40	38901	13189	50552994
Pseudarthrosis	24.81	12.35	10	38931	403	50565780
Psoriasis	24.80	12.35	11	38930	68989	50497194
Pelvic fracture	24.74	12.35	37	38904	11483	50554700
Hypersensitivity	24.65	12.35	84	38857	215077	50351106
Insomnia	24.59	12.35	62	38879	174803	50391380
Hospitalisation	24.15	12.35	11	38930	67926	50498257
Hepatitis acute	23.79	12.35	30	38911	7931	50558252
Acute kidney injury	23.69	12.35	274	38667	227784	50338399
Urinary retention	23.48	12.35	58	38883	26132	50540051
Localised infection	23.45	12.35	57	38884	25428	50540755
Chromaturia	23.34	12.35	41	38900	14549	50551634
Vasculitis	23.28	12.35	40	38901	13951	50552232
Blood pressure increased	23.04	12.35	42	38899	133090	50433093
Lividity	22.74	12.35	8	38933	220	50565963
Device stimulation issue	22.51	12.35	6	38935	62	50566121
Heart rate increased	22.47	12.35	16	38925	77234	50488949
Feeling abnormal	22.25	12.35	39	38902	125453	50440730
Psychotic symptom	22.19	12.35	13	38928	1199	50564984
Gastric ulcer	22.16	12.35	50	38891	21255	50544928
Death	22.14	12.35	153	38788	325226	50240957
Therapy non-responder	22.01	12.35	6	38935	51016	50515167
Suspected product contamination	21.91	12.35	5	38936	25	50566158
Peripheral circulatory failure	21.84	12.35	10	38931	552	50565631
Head discomfort	21.71	12.35	34	38907	10985	50555198
Gastritis erosive	21.47	12.35	23	38918	5111	50561072
Aortic valve stenosis	21.41	12.35	18	38923	2957	50563226
Injection site reaction	21.36	12.35	6	38935	50026	50516157
Paranasal sinus inflammation	21.33	12.35	9	38932	408	50565775
Hypoaesthesia	21.27	12.35	41	38900	127216	50438967
Injection site pruritus	21.09	12.35	3	38938	40408	50525775
Haemorrhagic erosive gastritis	21.08	12.35	8	38933	274	50565909
Gastrointestinal disorder	21.03	12.35	25	38916	94431	50471752
Lethargy	20.97	12.35	6	38935	49426	50516757
Medication overuse headache	20.68	12.35	10	38931	625	50565558
Fluid intake reduced	20.66	12.35	18	38923	3104	50563079
Bradycardia	20.48	12.35	101	38840	64325	50501858
Myocardial infarction	20.43	12.35	23	38918	89004	50477179
Gastroenteritis	20.29	12.35	51	38890	23230	50542953
Coombs negative haemolytic anaemia	20.05	12.35	7	38934	188	50565995
Vertigo	19.99	12.35	86	38855	51746	50514437
Acute abdomen	19.99	12.35	13	38928	1443	50564740
Off label use	19.83	12.35	252	38689	474174	50092009
Therapeutic response decreased	19.55	12.35	6	38935	47225	50518958
Necrotising fasciitis	19.25	12.35	16	38925	2588	50563595
Sensory level abnormal	19.19	12.35	6	38935	113	50566070
Left ventricular hypertrophy	19.03	12.35	21	38920	4824	50561359
Pneumobilia	18.99	12.35	6	38935	117	50566066
Peritoneal perforation	18.85	12.35	6	38935	120	50566063
Unevaluable event	18.80	12.35	6	38935	46060	50520123
Foreign body	18.63	12.35	14	38927	1957	50564226
Oliguria	18.53	12.35	27	38914	8189	50557994
Fluid retention	18.32	12.35	8	38933	50641	50515542
Stoma site inflammation	18.24	12.35	8	38933	399	50565784
Amnesia	18.17	12.35	5	38936	42255	50523928
Nail avulsion	18.06	12.35	6	38935	138	50566045
Conjunctivitis	18.05	12.35	39	38902	16106	50550077
Knee arthroplasty	17.94	12.35	3	38938	35843	50530340
Affective disorder	17.88	12.35	21	38920	5160	50561023
Spontaneous haemorrhage	17.85	12.35	7	38934	262	50565921
Patent ductus arteriosus	17.56	12.35	18	38923	3802	50562381
Flank pain	17.40	12.35	34	38907	13081	50553102
Sensory disturbance	17.34	12.35	32	38909	11797	50554386
Faeces pale	17.32	12.35	12	38929	1479	50564704
Injury	17.27	12.35	8	38933	48917	50517266
Liver function test increased	17.22	12.35	51	38890	25555	50540628
Neuropathy peripheral	17.21	12.35	30	38911	96727	50469456
Diverticulum intestinal	17.17	12.35	22	38919	5911	50560272
Internal haemorrhage	17.10	12.35	19	38922	4398	50561785
Gastritis	17.02	12.35	60	38881	32923	50533260
Peripheral arterial occlusive disease	16.87	12.35	17	38924	3520	50562663
Decreased appetite	16.84	12.35	232	38709	200691	50365492
Urogenital infection bacterial	16.51	12.35	4	38937	27	50566156
Lumbar vertebral fracture	16.48	12.35	19	38922	4578	50561605
Anaemia folate deficiency	16.47	12.35	6	38935	183	50566000
Merycism	16.40	12.35	6	38935	185	50565998
No adverse event	16.39	12.35	3	38938	33575	50532608
Painful respiration	16.33	12.35	14	38927	2361	50563822
Ill-defined disorder	16.32	12.35	11	38930	54643	50511540
Heart rate decreased	16.30	12.35	4	38937	36493	50529690
Haematuria	16.27	12.35	50	38891	25563	50540620
Cancer fatigue	16.15	12.35	4	38937	30	50566153
Hyperglycaemia	16.09	12.35	63	38878	36342	50529841
Brain contusion	16.05	12.35	8	38933	534	50565649
Urinary tract infection enterococcal	16.04	12.35	14	38927	2420	50563763
Inappropriate schedule of product administration	16.00	12.35	19	38922	71812	50494371
Peripheral swelling	15.96	12.35	93	38848	205843	50360340
Chills	15.89	12.35	128	38813	96559	50469624
Product used for unknown indication	15.77	12.35	7	38934	359	50565824
Urosepsis	15.76	12.35	36	38905	15429	50550754
Adverse event	15.69	12.35	7	38934	43756	50522427
Migraine	15.64	12.35	21	38920	75259	50490924
Bone marrow oedema	15.61	12.35	9	38932	805	50565378
Reticulocyte count increased	15.57	12.35	9	38932	809	50565374
Transaminases increased	15.57	12.35	52	38889	27772	50538411
Cellulitis	15.48	12.35	19	38922	70779	50495404
Hepatic enzyme increased	15.47	12.35	54	38887	137326	50428857
Pulmonary vein occlusion	15.43	12.35	5	38936	106	50566077
VIIIth nerve injury	15.22	12.35	3	38938	6	50566177
Cardiac murmur functional	15.12	12.35	4	38937	40	50566143
Hepatitis cholestatic	15.12	12.35	21	38920	6096	50560087
Myoclonus	15.10	12.35	34	38907	14436	50551747
Disease progression	15.07	12.35	32	38909	95834	50470349
Prescribed underdose	15.02	12.35	36	38905	15913	50550270
Prerenal failure	15	12.35	11	38930	1482	50564701
C-reactive protein increased	14.99	12.35	95	38846	66379	50499804
Metastatic malignant melanoma	14.95	12.35	10	38931	1164	50565019
Metastatic gastric cancer	14.93	12.35	5	38936	118	50566065
Duodenal ulcer	14.89	12.35	22	38919	6753	50559430
Coronavirus test positive	14.84	12.35	8	38933	628	50565555
Contusion	14.83	12.35	41	38900	112142	50454041
Kyphosis	14.72	12.35	13	38928	2282	50563901
Psoriatic arthropathy	14.68	12.35	9	38932	47023	50519160
Cardio-respiratory arrest	14.60	12.35	12	38929	53880	50512303
Circulatory collapse	14.57	12.35	41	38900	19959	50546224
Necrolytic migratory erythema	14.36	12.35	3	38938	9	50566174
Autoimmune colitis	14.33	12.35	7	38934	447	50565736
Lordosis	14.24	12.35	6	38935	271	50565912
Mucosal dryness	14.14	12.35	13	38928	2404	50563779
Cholestatic liver injury	14.08	12.35	12	38929	2009	50564174
Pleural effusion	14.02	12.35	109	38832	81345	50484838
Wrong patient received product	13.73	12.35	11	38930	1689	50564494
Petechiae	13.73	12.35	30	38911	12482	50553701
CD8 lymphocytes decreased	13.71	12.35	5	38936	153	50566030
Sinobronchitis	13.67	12.35	5	38936	154	50566029
Fatigue	13.64	12.35	428	38513	707173	49859010
Chronic fatigue syndrome	13.62	12.35	9	38932	1026	50565157
Systemic inflammatory response syndrome	13.49	12.35	18	38923	5031	50561152
Gastrointestinal tract adenoma	13.30	12.35	6	38935	320	50565863
Piloerection	13.30	12.35	6	38935	320	50565863
Ileus paralytic	13.29	12.35	16	38925	4034	50562149
Defaecation disorder	13.12	12.35	7	38934	538	50565645
Loss of personal independence in daily activities	13.12	12.35	21	38920	70029	50496154
Hyperkinesia	13.04	12.35	10	38931	1442	50564741
Cerebrovascular accident	12.96	12.35	34	38907	94646	50471537
Adverse drug reaction	12.96	12.35	14	38927	55208	50510975
Gastric mucosa erythema	12.89	12.35	5	38936	182	50566001
Gastrointestinal infection	12.80	12.35	21	38920	7053	50559130
Peripheral nerve lesion	12.75	12.35	6	38935	353	50565830
Rhonchi	12.71	12.35	12	38929	2295	50563888
Herpes zoster	12.54	12.35	22	38919	70764	50495419
Febrile infection	12.53	12.35	9	38932	1175	50565008
Unresponsive to stimuli	12.47	12.35	4	38937	30605	50535578
Substance dependence	12.46	12.35	5	38936	199	50565984
Pancreatic failure	12.45	12.35	8	38933	870	50565313
Cardiomyopathy alcoholic	12.42	12.35	3	38938	20	50566163
Hypertensive emergency	12.38	12.35	10	38931	1553	50564630

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1214.47	13.28	917	28265	101940	29443405
Product prescribing error	290.76	13.28	195	28987	17781	29527564
Systemic infection	171.50	13.28	68	29114	2033	29543312
Haematochezia	140.91	13.28	178	29004	36805	29508540
Drug ineffective	118.32	13.28	111	29071	363059	29182286
Anaemia	118.18	13.28	450	28732	200501	29344844
Product monitoring error	91.51	13.28	47	29135	2598	29542747
Death	90.16	13.28	124	29058	341960	29203385
Agranulocytosis	85.65	13.28	103	29079	20237	29525108
Abdominal pain	81.76	13.28	306	28876	135051	29410294
Pallor	81.31	13.28	102	29080	20922	29524423
Musculoskeletal pain	79.50	13.28	119	29063	28834	29516511
Completed suicide	76.00	13.28	3	29179	90243	29455102
Leukopenia	73.66	13.28	166	29016	55037	29490308
Abdominal pain upper	58.77	13.28	162	29020	60831	29484514
Fracture	58.04	13.28	48	29134	6005	29539340
Electrolyte imbalance	57.41	13.28	63	29119	11211	29534134
Malaise	56.33	13.28	45	29137	159557	29385788
Labelled drug-drug interaction medication error	51.87	13.28	62	29120	12097	29533248
Acute abdomen	51.79	13.28	28	29154	1719	29543626
Product dose omission issue	50.69	13.28	16	29166	96367	29448978
Vomiting	49.29	13.28	368	28814	211892	29333453
Paresis	47.52	13.28	27	29155	1827	29543518
Dyspnoea	44.61	13.28	505	28677	326227	29219118
Negative pressure pulmonary oedema	44.37	13.28	14	29168	209	29545136
Blood pressure measurement	43.43	13.28	13	29169	161	29545184
Nausea	43.10	13.28	455	28727	288800	29256545
Tachycardia	43.03	13.28	163	29019	72247	29473098
Neuromuscular block prolonged	41.36	13.28	16	29166	447	29544898
Disturbance in attention	41.17	13.28	75	29107	21349	29523996
C-reactive protein increased	41.07	13.28	116	29066	44147	29501198
Dyschezia	40.36	13.28	21	29161	1192	29544153
Mucosal haemorrhage	38.58	13.28	22	29160	1499	29543846
Tachypnoea	38.47	13.28	60	29122	15055	29530290
Neuropathy peripheral	36.97	13.28	12	29170	71015	29474330
Platelet dysfunction	36.58	13.28	12	29170	204	29545141
Myocardial infarction	36.55	13.28	33	29149	110263	29435082
Polyneuropathy	36.31	13.28	52	29130	12100	29533245
Pyrexia	34.54	13.28	434	28748	287188	29258157
Appendicolith	34.20	13.28	28	29154	3452	29541893
Micturition disorder	34.05	13.28	22	29160	1879	29543466
Restlessness	33.39	13.28	70	29112	22075	29523270
Fall	33.37	13.28	293	28889	176885	29368460
Oedema peripheral	33.35	13.28	195	28987	103362	29441983
Weight bearing difficulty	31.65	13.28	16	29166	855	29544490
Gamma-glutamyltransferase increased	30.84	13.28	76	29106	26661	29518684
Impaired healing	30.65	13.28	51	29131	13507	29531838
Toxic epidermal necrolysis	30.48	13.28	60	29122	18093	29527252
Constipation	29.94	13.28	204	28978	113956	29431389
Toxicity to various agents	29.80	13.28	81	29101	173580	29371765
Cachexia	29.79	13.28	34	29148	6315	29539030
Leptotrichia infection	28.74	13.28	8	29174	75	29545270
Dizziness	28.45	13.28	299	28883	189385	29355960
Blood pressure increased	28.35	13.28	19	29163	73784	29471561
Accessory spleen	27.94	13.28	9	29173	144	29545201
Interstitial lung disease	27.90	13.28	11	29171	57707	29487638
Electrocardiogram abnormal	27.46	13.28	35	29147	7287	29538058
Product administration error	27.36	13.28	50	29132	14260	29531085
Hospitalisation	27.27	13.28	6	29176	45982	29499363
Therapeutic drug monitoring analysis not performed	27.03	13.28	12	29170	478	29544867
Feeling abnormal	26.94	13.28	10	29172	54435	29490910
Treatment failure	25.98	13.28	3	29179	36936	29508409
Malignant neoplasm progression	25.68	13.28	142	29040	73717	29471628
Hydrocholecystis	25.59	13.28	10	29172	287	29545058
Suspected product contamination	25.50	13.28	7	29175	62	29545283
Infusion related reaction	25.47	13.28	6	29176	43880	29501465
Wound	25.45	13.28	44	29138	12019	29533326
Platelet count decreased	25.41	13.28	40	29142	104632	29440713
Depressed level of consciousness	25.18	13.28	87	29095	36855	29508490
Product prescribing issue	24.66	13.28	15	29167	1152	29544193
Hypertensive crisis	24.06	13.28	34	29148	7814	29537531
Long QT syndrome	23.96	13.28	19	29163	2239	29543106
Iris adhesions	23.69	13.28	9	29173	239	29545106
Contraindicated product administered	23.30	13.28	54	29128	18212	29527133
Hepatorenal failure	23.01	13.28	11	29171	520	29544825
Tension headache	22.54	13.28	15	29167	1346	29543999
Angioedema	22.48	13.28	76	29106	31839	29513506
Cardiac arrest	22.44	13.28	31	29151	85560	29459785
Cold sweat	22.36	13.28	35	29147	8807	29536538
Erysipelas	22.19	13.28	24	29158	4201	29541144
Implant site inflammation	22.15	13.28	7	29175	105	29545240
Medication error	22.07	13.28	58	29124	21153	29524192
Drug abuse	21.89	13.28	28	29154	79855	29465490
Drug reaction with eosinophilia and systemic symptoms	21.82	13.28	69	29113	27923	29517422
Osteochondrosis	21.35	13.28	12	29170	795	29544550
Thirst	21.21	13.28	29	29153	6462	29538883
Hyperventilation	21.13	13.28	18	29164	2344	29543001
Suspected product quality issue	20.47	13.28	7	29175	136	29545209
Joint swelling	20.12	13.28	12	29170	49618	29495727
Pseudarthrosis	20.07	13.28	6	29176	74	29545271
Immobile	19.86	13.28	17	29165	2228	29543117
Appendicitis	19.81	13.28	33	29149	8746	29536599
Thrombosis	19.53	13.28	9	29173	43036	29502309
Mineral supplementation	19.50	13.28	6	29176	82	29545263
Febrile infection	19.43	13.28	16	29166	1988	29543357
Hepatic cyst	19.35	13.28	17	29165	2308	29543037
Tracheal atresia	19.30	13.28	4	29178	8	29545337
Therapeutic product effect decreased	19.26	13.28	3	29179	29448	29515897
Toxic neuropathy	19.02	13.28	9	29173	416	29544929
Intestinal haemorrhage	18.87	13.28	19	29163	3060	29542285
Abdominal discomfort	18.84	13.28	12	29170	47891	29497454
Haematoma	18.82	13.28	58	29124	23154	29522191
Chronic fatigue syndrome	18.80	13.28	8	29174	287	29545058
Flank pain	18.76	13.28	26	29156	5867	29539478
Genitourinary tract infection	18.51	13.28	6	29176	98	29545247
Jaundice	18.25	13.28	67	29115	29229	29516116
Pulmonary sepsis	18.25	13.28	15	29167	1859	29543486
Dysdiadochokinesis	18.25	13.28	7	29175	191	29545154
Adrenocortical insufficiency acute	18.21	13.28	13	29169	1307	29544038
Therapy partial responder	18.17	13.28	24	29158	5175	29540170
Platelet function test abnormal	18.13	13.28	6	29176	105	29545240
Vertigo	18.07	13.28	55	29127	21806	29523539
Haematemesis	17.66	13.28	59	29123	24567	29520778
Tonsillitis	17.43	13.28	15	29167	1980	29543365
Disease progression	17.42	13.28	34	29148	81882	29463463
Haemorrhagic necrotic pancreatitis	17.25	13.28	6	29176	123	29545222
Urogenital infection bacterial	17.16	13.28	5	29177	56	29545289
Paraparesis	16.93	13.28	14	29168	1750	29543595
Reflux nephropathy	16.92	13.28	5	29177	59	29545286
Cardiovascular disorder	16.80	13.28	31	29151	8904	29536441
Fear of disease	16.69	13.28	7	29175	242	29545103
Therapy non-responder	16.47	13.28	5	29177	30906	29514439
Blood folate increased	16.45	13.28	7	29175	251	29545094
Thrombocytopenia	16.33	13.28	204	28978	134619	29410726
Spinal cord injury cauda equina	16.29	13.28	6	29176	146	29545199
Somatosensory evoked potentials abnormal	16.06	13.28	6	29176	152	29545193
Breath sounds normal	15.69	13.28	3	29179	3	29545342
Nail bed inflammation	15.63	13.28	6	29176	164	29545181
Unevaluable event	15.60	13.28	5	29177	29846	29515499
Oedematous pancreatitis	15.59	13.28	8	29174	441	29544904
Unresponsive to stimuli	15.47	13.28	3	29179	25123	29520222
Drug intolerance	15.39	13.28	15	29167	48364	29496981
Coma	15.35	13.28	10	29172	39440	29505905
Vitamin B6 deficiency	15.27	13.28	6	29176	175	29545170
Mycobacterium fortuitum infection	15.27	13.28	6	29176	175	29545170
Food interaction	15.10	13.28	10	29172	890	29544455
Product packaging confusion	14.93	13.28	4	29178	32	29545313
Hyponatraemia	14.91	13.28	116	29066	67517	29477828
Flushing	14.90	13.28	5	29177	28987	29516358
Spinal pain	14.80	13.28	21	29161	4843	29540502
Autoimmune hepatitis	14.76	13.28	18	29164	3584	29541761
Fear of falling	14.68	13.28	7	29175	329	29545016
Quality of life decreased	14.51	13.28	17	29165	3245	29542100
Preternatural anus	14.49	13.28	5	29177	100	29545245
Lack of application site rotation	14.48	13.28	3	29179	6	29545339
Wrong product administered	14.44	13.28	20	29162	4511	29540834
Oral herpes	14.44	13.28	20	29162	4512	29540833
Paraplegia	14.38	13.28	15	29167	2519	29542826
Target skin lesion	14.16	13.28	3	29179	7	29545338
Flatulence	14.12	13.28	44	29138	17665	29527680
Aspirin-exacerbated respiratory disease	14.11	13.28	7	29175	359	29544986
Creatinine renal clearance abnormal	14.11	13.28	6	29176	215	29545130
Upper respiratory tract irritation	14.05	13.28	4	29178	41	29545304
Decreased vibratory sense	14.01	13.28	7	29175	365	29544980
Polyneuropathy in malignant disease	13.96	13.28	5	29177	112	29545233
Urosepsis	13.96	13.28	32	29150	10714	29534631
Chills	13.94	13.28	119	29063	71181	29474164
Procedural pain	13.93	13.28	19	29163	4225	29541120
Abdominal distension	13.82	13.28	85	29097	45826	29499519
Cardiac disorder	13.76	13.28	10	29172	37253	29508092
Administration site discomfort	13.71	13.28	4	29178	45	29545300
Urine uric acid decreased	13.64	13.28	5	29177	120	29545225
Tracheal pain	13.63	13.28	4	29178	46	29545299
Anaemia of malignant disease	13.59	13.28	7	29175	389	29544956
Type I hypersensitivity	13.52	13.28	10	29172	1062	29544283
Urinary sediment abnormal	13.48	13.28	5	29177	124	29545221
Ureteric dilatation	13.37	13.28	5	29177	127	29545218
Bladder spasm	13.36	13.28	9	29173	824	29544521
Drug delivery device placement	13.33	13.28	5	29177	128	29545217
Bifascicular block	13.33	13.28	6	29176	247	29545098
Heart rate decreased	13.33	13.28	4	29178	24908	29520437

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	2441.91	12.11	1811	59700	202614	64234607
Product prescribing error	754.80	12.11	451	61060	34818	64402403
Haematochezia	424.03	12.11	412	61099	65961	64371260
Systemic infection	340.31	12.11	135	61376	4186	64433035
Anaemia	334.78	12.11	952	60559	377728	64059493
Agranulocytosis	289.61	12.11	261	61250	37968	64399253
Product monitoring error	280.93	12.11	126	61385	5328	64431893
Fracture	230.88	12.11	170	61341	18585	64418636
Drug ineffective	220.78	12.11	288	61223	839959	63597262
Pallor	173.08	12.11	199	61312	38582	64398639
Completed suicide	154.28	12.11	17	61494	224397	64212824
Leukopenia	141.57	12.11	304	61207	100938	64336283
Abdominal pain	139.89	12.11	629	60882	311746	64125475
Aspirin-exacerbated respiratory disease	137.88	12.11	49	61462	1111	64436110
Labelled drug-drug interaction medication error	133.38	12.11	133	61378	21929	64415292
Fall	130.48	12.11	759	60752	416067	64021154
Haematemesis	129.42	12.11	190	61321	46809	64390412
Polyneuropathy	122.25	12.11	121	61390	19773	64417448
Abdominal pain upper	118.70	12.11	402	61109	174628	64262593
Malaise	116.24	12.11	124	61387	396123	64041098
Vomiting	115.77	12.11	909	60602	550208	63887013
Joint swelling	114.15	12.11	32	61479	215350	64221871
Product administration error	113.60	12.11	136	61375	27507	64409714
Product dose omission issue	112.83	12.11	24	61487	194723	64242498
Musculoskeletal pain	112.36	12.11	243	61268	81051	64356170
Restlessness	109.77	12.11	161	61350	39624	64397597
Dyspnoea	109.61	12.11	1105	60406	717569	63719652
Electrolyte imbalance	106.71	12.11	126	61385	25117	64412104
Nausea	105.27	12.11	1177	60334	784623	63652598
Tachypnoea	96.73	12.11	123	61388	26448	64410773
Infusion related reaction	95.81	12.11	20	61491	164447	64272774
Abdominal discomfort	87.88	12.11	32	61479	182290	64254931
Cardiac failure congestive	86.94	12.11	11	61500	130569	64306652
Toxic epidermal necrolysis	86.48	12.11	139	61372	37027	64400194
Disturbance in attention	84.04	12.11	145	61366	40929	64396292
Tachycardia	83.89	12.11	323	61188	149256	64287965
Pyrexia	78.33	12.11	845	60666	557799	63879422
Treatment failure	77.38	12.11	10	61501	116806	64320415
Abdominal pain lower	77.21	12.11	110	61401	26359	64410862
Oedema peripheral	74.94	12.11	397	61114	209920	64227301
Synovitis	74.87	12.11	5	61506	99085	64338136
Therapeutic product effect decreased	71.50	12.11	12	61499	115339	64321882
Constipation	71.13	12.11	417	61094	228920	64208301
Sinusitis	69.66	12.11	26	61485	145902	64291319
Lower respiratory tract infection	68.03	12.11	6	61505	94608	64342613
Arthropathy	67.84	12.11	16	61495	120951	64316270
Jaundice	66.99	12.11	145	61366	48367	64388854
Erysipelas	66.76	12.11	61	61450	9020	64428201
Gamma-glutamyltransferase increased	64.72	12.11	143	61368	48367	64388854
Medication error	64.09	12.11	145	61366	49821	64387400
Injection site pain	63.94	12.11	14	61497	111394	64325827
Drug intolerance	63.05	12.11	52	61459	187940	64249281
Osteochondrosis	62.98	12.11	30	61481	1457	64435764
Death	61.84	12.11	244	61267	482461	63954760
Hepatorenal failure	60.11	12.11	27	61484	1145	64436076
Blood pressure increased	60.04	12.11	46	61465	172506	64264715
Swelling	59.29	12.11	40	61471	160178	64277043
Musculoskeletal stiffness	58.72	12.11	22	61489	123184	64314037
Drug-induced liver injury	58.61	12.11	136	61375	47507	64389714
Suspected product quality issue	58.45	12.11	18	61493	256	64436965
Apathy	57.59	12.11	62	61449	11170	64426051
Acute abdomen	57.46	12.11	35	61476	2789	64434432
Cachexia	56.51	12.11	56	61455	9161	64428060
Therapeutic drug monitoring analysis not performed	56.11	12.11	26	61485	1186	64436035
Dizziness	55.75	12.11	641	60870	429522	64007699
Malignant neoplasm progression	55.48	12.11	234	61277	112637	64324584
Lethargy	53.86	12.11	4	61507	72590	64364631
Haematoma	53.61	12.11	129	61382	46121	64391100
Drug hypersensitivity	50.15	12.11	94	61417	237721	64199500
Dyschezia	49.38	12.11	30	61481	2380	64434841
Nasal disorder	49.29	12.11	32	61479	2852	64434369
Myocardial infarction	48.40	12.11	52	61459	165769	64271452
Paresis	47.98	12.11	34	61477	3498	64433723
Suspected product contamination	46.85	12.11	12	61499	82	64437139
Feeling abnormal	45.98	12.11	36	61475	133566	64303655
Mucosal haemorrhage	45.72	12.11	28	61483	2253	64434968
Dehydration	45.51	12.11	358	61153	216405	64220816
Negative pressure pulmonary oedema	44.59	12.11	14	61497	213	64437008
Thirst	44.58	12.11	61	61450	14076	64423145
Nasopharyngitis	44.50	12.11	74	61437	195999	64241222
Toxicity to various agents	44.45	12.11	187	61324	363326	64073895
Interstitial lung disease	44.03	12.11	19	61492	97713	64339508
Subileus	43.74	12.11	37	61474	4940	64432281
Drug reaction with eosinophilia and systemic symptoms	43.47	12.11	132	61379	54085	64383136
Immobile	43.43	12.11	40	61471	5975	64431246
Pemphigus	43.22	12.11	4	61507	60697	64376524
Stevens-Johnson syndrome	40.20	12.11	96	61415	34153	64403068
Rheumatoid arthritis	40.14	12.11	59	61452	164235	64272986
Renal impairment	39.56	12.11	242	61269	134775	64302446
Tumour pain	39.44	12.11	24	61487	1909	64435312
Type I hypersensitivity	38.66	12.11	30	61481	3544	64433677
Systemic lupus erythematosus	38.44	12.11	13	61498	77599	64359622
Electrocardiogram abnormal	37.81	12.11	55	61456	13426	64423795
Arthralgia	37.68	12.11	257	61254	442003	63995218
Psoriasis	37.31	12.11	11	61500	71692	64365529
Dysuria	37.16	12.11	106	61405	41951	64395270
Wound	37.13	12.11	158	61353	76319	64360902
Drug interaction	36.40	12.11	515	60996	361568	64075653
Neuropathy peripheral	36.39	12.11	35	61476	117490	64319731
Urogenital haemorrhage	35.94	12.11	16	61495	664	64436557
Thrombocytopenia	35.71	12.11	348	61163	223453	64213768
Syncope	35.66	12.11	265	61246	157370	64279851
Pericarditis	35.57	12.11	8	61503	62508	64374713
Nasal congestion	35.25	12.11	7	61504	59651	64377570
Therapy non-responder	34.49	12.11	10	61501	65889	64371332
Flank pain	34.22	12.11	58	61453	16131	64421090
Maternal exposure during pregnancy	34.06	12.11	25	61486	95859	64341362
Respiratory arrest	33.98	12.11	5	61506	52980	64384241
Cellulitis	33.81	12.11	24	61487	93633	64343588
Blood pressure measurement	33.38	12.11	13	61498	383	64436838
Spinal pain	33.25	12.11	50	61461	12571	64424650
Platelet count decreased	33.00	12.11	69	61442	167642	64269579
Appendicolith	33.00	12.11	27	61484	3442	64433779
Acute hepatic failure	32.61	12.11	75	61436	26037	64411184
Hepatitis acute	32.41	12.11	51	61460	13338	64423883
Faecaloma	32.23	12.11	43	61468	9685	64427536
Urogenital infection bacterial	32.11	12.11	9	61502	90	64437131
Chills	31.75	12.11	232	61279	137032	64300189
Hospitalisation	31.75	12.11	16	61495	75191	64362030
Hypokalaemia	31.70	12.11	212	61299	121691	64315530
Alopecia	31.08	12.11	70	61441	165620	64271601
C-reactive protein increased	30.95	12.11	175	61336	94734	64342487
Angina pectoris	30.89	12.11	104	61407	44977	64392244
Platelet dysfunction	30.83	12.11	12	61499	353	64436868
Disease progression	30.74	12.11	55	61456	141625	64295596
Arrhythmia	30.19	12.11	115	61396	52829	64384392
Chronic fatigue syndrome	30.08	12.11	17	61494	1178	64436043
Listless	30.03	12.11	25	61486	3265	64433956
Abdominal distension	29.99	12.11	175	61336	95819	64341402
Heart rate increased	29.84	12.11	30	61481	98645	64338576
Injection site swelling	28.72	12.11	3	61508	41350	64395871
Injection site erythema	28.51	12.11	16	61495	70784	64366437
Febrile infection	28.48	12.11	23	61488	2878	64434343
Off label use	28.34	12.11	429	61082	632377	63804844
Bicytopenia	27.94	12.11	25	61486	3597	64433624
Reduced facial expression	27.92	12.11	20	61491	2093	64435128
Depressed level of consciousness	27.78	12.11	152	61359	81284	64355937
Ascites	27.74	12.11	125	61386	61876	64375345
Heart rate decreased	27.66	12.11	9	61502	55058	64382163
Neuromuscular block prolonged	27.62	12.11	15	61496	962	64436259
Unresponsive to stimuli	27.59	12.11	7	61504	50386	64386835
Pancytopenia	27.51	12.11	232	61279	143077	64294144
Cardio-respiratory arrest	27.44	12.11	32	61479	98361	64338860
Therapeutic product effect incomplete	27.44	12.11	35	61476	103447	64333774
Product use issue	26.93	12.11	66	61445	151649	64285572
Bradycardia	26.87	12.11	199	61312	118020	64319201
Micturition disorder	26.84	12.11	23	61488	3125	64434096
Facial nerve disorder	26.79	12.11	13	61498	658	64436563
Hypoaesthesia	26.72	12.11	58	61453	139050	64298171
Gastritis erosive	26.70	12.11	39	61472	9556	64427665
Accessory spleen	26.57	12.11	9	61502	176	64437045
Orthostatic hypotension	26.55	12.11	6	61505	46732	64390489
Contusion	25.85	12.11	43	61468	113922	64323299
Angioedema	25.71	12.11	122	61389	61699	64375522
Fluid intake reduced	25.43	12.11	28	61483	5172	64432049
Gastrointestinal disorder	25.21	12.11	29	61482	89680	64347541
Vertigo	24.94	12.11	117	61394	58894	64378327
Hypersensitivity	24.63	12.11	100	61411	196352	64240869
Haemorrhagic necrotic pancreatitis	24.62	12.11	7	61504	74	64437147
Disorientation	24.56	12.11	112	61399	55716	64381505
Hydrocholecystis	24.28	12.11	10	61501	342	64436879
Nail toxicity	24.17	12.11	10	61501	346	64436875
Long QT syndrome	23.98	12.11	27	61484	5112	64432109
Helicobacter infection	23.74	12.11	4	61507	38358	64398863
Hepatitis cholestatic	23.67	12.11	42	61469	12113	64425108
Decreased appetite	23.57	12.11	388	61123	280901	64156320
Blood pressure fluctuation	23.49	12.11	10	61501	51861	64385360
Flatulence	23.31	12.11	81	61430	35585	64401636
Rash	23.28	12.11	303	61208	458246	63978975
Drug resistance	23.25	12.11	3	61508	35099	64402122
Thirst decreased	23.12	12.11	9	61502	265	64436956
Loss of personal independence in daily activities	23.11	12.11	21	61490	72433	64364788
Upper gastrointestinal haemorrhage	23.03	12.11	80	61431	35140	64402081
Gallbladder polyp	23.03	12.11	13	61498	899	64436322
Post-traumatic pain	22.95	12.11	10	61501	394	64436827
Cardiac arrest	22.91	12.11	73	61438	153991	64283230
Delirium	22.83	12.11	128	61383	69066	64368155
Psychotic disorder	22.79	12.11	3	61508	34575	64402646
Migraine	22.70	12.11	16	61495	62661	64374560
Flushing	22.56	12.11	25	61486	78623	64358598
Unevaluable event	22.45	12.11	10	61501	50479	64386742
Drug abuse	22.40	12.11	59	61452	132315	64304906
Therapeutic response decreased	22.18	12.11	11	61500	52177	64385044
Haematuria	22.07	12.11	115	61396	60356	64376865
Adverse drug reaction	21.85	12.11	8	61503	45456	64391765
Dysdiadochokinesis	21.84	12.11	9	61502	308	64436913
Discomfort	21.81	12.11	27	61484	80851	64356370
Weight increased	21.79	12.11	117	61394	213231	64223990
Tension headache	21.57	12.11	21	61490	3362	64433859
Product used for unknown indication	21.42	12.11	12	61499	818	64436403
Muscle tone disorder	21.25	12.11	7	61504	125	64437096
Blood folate increased	21.20	12.11	10	61501	475	64436746
Injection site reaction	21.13	12.11	9	61502	46655	64390566
Coombs negative haemolytic anaemia	20.84	12.11	9	61502	347	64436874
Urosepsis	20.81	12.11	57	61454	22037	64415184
Hyperventilation	20.79	12.11	29	61482	6811	64430410
Cerebrovascular accident	20.59	12.11	65	61446	137518	64299703
Cardiac disorder	20.55	12.11	14	61497	55802	64381419
Acute generalised exanthematous pustulosis	20.53	12.11	43	61468	14015	64423206
Hepatitis toxic	20.33	12.11	23	61488	4377	64432844
Blood pressure decreased	20.04	12.11	32	61479	86167	64351054
Pelvic fracture	19.93	12.11	36	61475	10527	64426694
Oropharyngeal discomfort	19.89	12.11	25	61486	5310	64431911
Vascular encephalopathy	19.63	12.11	10	61501	562	64436659
Peripheral swelling	19.57	12.11	118	61393	209035	64228186
Pseudarthrosis	19.47	12.11	8	61503	272	64436949
Pulmonary sepsis	19.44	12.11	19	61492	3056	64434165
Depression	19.00	12.11	100	61411	183191	64254030
Irritable bowel syndrome	18.96	12.11	6	61505	37363	64399858
Hepatic function abnormal	18.94	12.11	20	61491	64293	64372928
Folliculitis	18.92	12.11	3	61508	30074	64407147
Pneumobilia	18.69	12.11	7	61504	185	64437036
Duodenal ulcer	18.62	12.11	42	61469	14393	64422828
Gastrointestinal sounds abnormal	18.55	12.11	23	61488	4820	64432401
Localised infection	18.43	12.11	67	61444	30094	64407127
Fluid retention	18.16	12.11	18	61493	59588	64377633
Inappropriate schedule of product administration	18.12	12.11	38	61473	92248	64344973
Disease recurrence	17.99	12.11	4	61507	31506	64405715
Anaemia of malignant disease	17.98	12.11	10	61501	672	64436549
Peripheral circulatory failure	17.86	12.11	10	61501	681	64436540
Multiple organ dysfunction syndrome	17.80	12.11	161	61350	101252	64335969
Hyponatraemia	17.78	12.11	218	61293	148121	64289100
Hyperglycaemia	17.66	12.11	109	61402	60859	64376362
Fibromyalgia	17.66	12.11	6	61505	35725	64401496
Weight bearing difficulty	17.65	12.11	17	61494	2686	64434535
Implant site inflammation	17.61	12.11	7	61504	218	64437003
Medication overuse headache	17.60	12.11	10	61501	700	64436521
White blood cell count decreased	17.56	12.11	84	61427	157753	64279468
Hypoxia	17.55	12.11	36	61475	88113	64349108
Ileus	17.55	12.11	55	61456	22911	64414310
Product packaging confusion	17.43	12.11	7	61504	224	64436997
Paraparesis	17.37	12.11	19	61492	3483	64433738
Wrong technique in product usage process	17.20	12.11	22	61489	64952	64372269
Head injury	17.15	12.11	5	61506	32837	64404384
Hepatic cyst	17.11	12.11	23	61488	5217	64432004
Psoriatic arthropathy	17.11	12.11	10	61501	43271	64393950
Lividity	17.04	12.11	8	61503	376	64436845
Exposure during pregnancy	16.98	12.11	30	61481	77645	64359576
Gastritis	16.92	12.11	83	61428	42535	64394686
Rash pruritic	16.73	12.11	18	61493	57386	64379835
Antineutrophil cytoplasmic antibody positive	16.73	12.11	11	61500	1001	64436220
Tonsillitis	16.69	12.11	24	61487	5796	64431425
Product prescribing issue	16.60	12.11	15	61496	2186	64435035
Full blood count abnormal	16.55	12.11	4	61507	29753	64407468
Spinal cord injury cauda equina	16.48	12.11	6	61505	146	64437075
Vasculitis	16.36	12.11	46	61465	18049	64419172
Type 2 diabetes mellitus	16.32	12.11	6	61505	34014	64403207
Knee arthroplasty	16.30	12.11	3	61508	26996	64410225
Hypertensive crisis	16.12	12.11	46	61465	18202	64419019
International normalised ratio increased	16.05	12.11	32	61479	79135	64358086
Appendicitis	15.88	12.11	38	61473	13531	64423690
Vitamin B6 deficiency	15.87	12.11	7	61504	284	64436937
Breath sounds normal	15.79	12.11	3	61508	3	64437218
Respiratory alkalosis	15.72	12.11	19	61492	3878	64433343
Seizure	15.69	12.11	94	61417	166798	64270423
Pulmonary hypertension	15.64	12.11	11	61500	43128	64394093
Cardiac failure	15.63	12.11	194	61317	132179	64305042
Peritoneal perforation	15.63	12.11	6	61505	170	64437051
Prescribed underdose	15.52	12.11	45	61466	17970	64419251
Hepatic failure	15.40	12.11	98	61413	55296	64381925
Amnesia	15.38	12.11	14	61497	48255	64388966
Haemorrhagic erosive gastritis	15.38	12.11	8	61503	470	64436751
Necrotising fasciitis	15.33	12.11	22	61489	5304	64431917
Somatosensory evoked potentials abnormal	15.27	12.11	6	61505	181	64437040
Product impurity	15.25	12.11	5	61506	88	64437133
Agitation	15.24	12.11	39	61472	88328	64348893
Oliguria	15.14	12.11	39	61472	14537	64422684
Lordosis	15.05	12.11	7	61504	322	64436899
Hypervolaemia	14.91	12.11	9	61502	38276	64398945
Conjunctivitis	14.88	12.11	48	61463	20306	64416915
Head discomfort	14.79	12.11	34	61477	11800	64425421
Preternatural anus	14.65	12.11	5	61506	100	64437121
Hepatocellular injury	14.55	12.11	13	61498	45222	64391999
Mycobacterium fortuitum infection	14.55	12.11	6	61505	206	64437015
Cross sensitivity reaction	14.55	12.11	17	61494	3350	64433871
Prescription drug used without a prescription	14.48	12.11	15	61496	2585	64434636
Subacute hepatic failure	14.46	12.11	6	61505	209	64437012
Visual acuity reduced	14.42	12.11	4	61507	27137	64410084
Cardiac murmur functional	14.36	12.11	4	61507	39	64437182
Toxic neuropathy	14.02	12.11	9	61502	787	64436434
Hyperaemia	13.97	12.11	15	61496	2694	64434527
Solar dermatitis	13.95	12.11	6	61505	229	64436992
Urine uric acid decreased	13.80	12.11	5	61506	120	64437101
Bulimia nervosa	13.78	12.11	6	61505	236	64436985
Ill-defined disorder	13.77	12.11	13	61498	44039	64393182
Tracheal pain	13.77	12.11	4	61507	46	64437175
VIIIth nerve injury	13.72	12.11	3	61508	9	64437212
Necrolytic migratory erythema	13.72	12.11	3	61508	9	64437212
Anaemia folate deficiency	13.59	12.11	6	61505	244	64436977
Reactive gastropathy	13.43	12.11	7	61504	413	64436808
Anxiety	13.40	12.11	126	61385	202523	64234698
Lumbar vertebral fracture	13.37	12.11	21	61490	5481	64431740
Pulmonary vein occlusion	13.35	12.11	5	61506	132	64437089
Intestinal haemorrhage	13.34	12.11	21	61490	5493	64431728
Headache	13.29	12.11	394	61117	529073	63908148
Sensory level abnormal	13.28	12.11	5	61506	134	64437087
Skin irritation	13.28	12.11	28	61483	9166	64428055
Genitourinary tract infection	13.28	12.11	6	61505	258	64436963
Spontaneous haemorrhage	13.18	12.11	7	61504	429	64436792
Concomitant disease aggravated	13.16	12.11	32	61479	11510	64425711
Adverse event	13.13	12.11	11	61500	39478	64397743
Oedematous pancreatitis	13.12	12.11	9	61502	879	64436342
Laryngeal oedema	13.11	12.11	24	61487	7089	64430132
Food interaction	13.09	12.11	11	61500	1455	64435766
Transaminases increased	13.09	12.11	80	61431	44514	64392707
Urinary sediment abnormal	13.08	12.11	5	61506	140	64437081
Confusional state	13.06	12.11	173	61338	260971	64176250
Leptotrichia infection	13.05	12.11	4	61507	56	64437165
Stenosis	12.97	12.11	12	61499	1803	64435418
Fear of disease	12.96	12.11	9	61502	896	64436325
Hyperkinesia	12.96	12.11	14	61497	2532	64434689
Wrong product administered	12.93	12.11	25	61486	7695	64429526
Colitis	12.89	12.11	98	61413	58576	64378645
Oral candidiasis	12.88	12.11	50	61461	23162	64414059
Adrenocortical insufficiency acute	12.87	12.11	14	61497	2551	64434670
Organic brain syndrome	12.86	12.11	7	61504	451	64436770
Mucosal dryness	12.71	12.11	15	61496	2986	64434235
Lack of application site rotation	12.68	12.11	3	61508	14	64437207
Gastric disorder	12.64	12.11	6	61505	29191	64408030
Polyneuropathy in malignant disease	12.60	12.11	5	61506	155	64437066
Alpha 2 globulin increased	12.60	12.11	5	61506	155	64437066
Rhabdomyolysis	12.58	12.11	45	61466	91681	64345540
Pure white cell aplasia	12.55	12.11	4	61507	64	64437157
Brain contusion	12.54	12.11	10	61501	1229	64435992
Tumour haemorrhage	12.44	12.11	16	61495	3477	64433744
Non-small cell lung cancer	12.35	12.11	19	61492	4871	64432350
Arthritis	12.25	12.11	40	61471	83774	64353447
Peripheral arterial occlusive disease	12.16	12.11	23	61488	6964	64430257
Ureteric dilatation	12.14	12.11	5	61506	171	64437050
Paraplegia	12.13	12.11	18	61493	4472	64432749

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N02BB02	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB52	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB72	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D058633	Antipyretics
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:35493	anti-pyretic
CHEBI has role	CHEBI:35842	anti-rheumatic drugs
CHEBI has role	CHEBI:49110	peripheral nervous system drugs
CHEBI has role	CHEBI:50266	Prodrugs
CHEBI has role	CHEBI:73263	cyclooxygenase-3 inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
Zimeta	Kindred Biosciences Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	0.21	acidic
pKa2	5.06	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Transient receptor potential cation channel subfamily A member 1	Ion channel	O75762	TRPA1_HUMAN	BLOCKER	IC50	4.04		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D08190	KEGG_DRUG
N0000167060	NUI
5907-38-0	SECONDARY_CAS_RN
CHEBI:59033	CHEBI
CHEMBL3989803	ChEMBL_ID
C024864	MESH_SUPPLEMENTAL_RECORD_UI
10608	IUPHAR_LIGAND_ID
6150-97-6	SECONDARY_CAS_RN
51996-59-9	SECONDARY_CAS_RN
DB04817	DRUGBANK_ID
934T64RMNJ	UNII
3111	PUBCHEM_CID
1537943	RXNORM
NOCODE	MMSL
001609	NDDF
006029	NDDF
22165008	SNOMEDCT_US
735071007	SNOMEDCT_US
780831000	SNOMEDCT_US
781025005	SNOMEDCT_US
D004177	MESH_DESCRIPTOR_UI
C0012586	UMLSCUI
CHEMBL461522	ChEMBL_ID
477	INN_ID
50567-35-6	SECONDARY_CAS_RN

Pharmaceutical products:

None