metamizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory analgesics, phenylbutazone derivatives	4659	68-89-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: algocalmin metamizole metamizole sodium metamizol metapyrin methampyrone dipyrone dipyrone monohydrate sulpyrine metamizole magnesium metamizole calcium	A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Molecular weight: 311.36 Formula: C13H17N3O4S CLOGP: -1.20 LIPINSKI: 0 HAC: 7 HDO: 1 TPSA: 81.16 ALOGS: -2.09 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

algocalmin
metamizole
metamizole sodium
metamizol
metapyrin
methampyrone
dipyrone
dipyrone monohydrate
sulpyrine
metamizole magnesium
metamizole calcium

A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.

Molecular weight: 311.36
Formula: C13H17N3O4S
CLOGP: -1.20
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 81.16
ALOGS: -2.09
ROTB: 4

Drug dosage:

Dose	Unit	Route
3	g	O
3	g	P
3	g	R

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1507.27	12.66	1229	46541	200173	63241079
Product prescribing error	639.37	12.66	337	47433	25952	63415300
Systemic infection	383.59	12.66	141	47629	4519	63436733
Haematochezia	365.67	12.66	311	47459	53233	63388019
Anaemia	340.30	12.66	708	47062	292722	63148530
Agranulocytosis	326.96	12.66	215	47555	24919	63416333
Product monitoring error	325.59	12.66	124	47646	4392	63436860
Drug ineffective	253.90	12.66	249	47521	1044516	62396736
Labelled drug-drug interaction medication error	217.75	12.66	132	47638	13267	63427985
Fracture	201.45	12.66	145	47625	19439	63421813

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1576.94	13.58	1228	37530	127041	34791132
Product prescribing error	406.07	13.58	275	38483	22652	34895521
Systemic infection	299.55	13.58	136	38622	5076	34913097
Product monitoring error	228.87	13.58	107	38651	4274	34913899
Anaemia	202.13	13.58	642	38116	232693	34685480
Drug ineffective	181.78	13.58	145	38613	456606	34461567
Haematochezia	176.38	13.58	237	38521	46297	34871876
Appendicolith	144.65	13.58	100	38658	8501	34909672
Abdominal pain	140.25	13.58	449	38309	163169	34755004
Appendicitis	110.10	13.58	107	38651	14700	34903473

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	3065.61	12.06	2365	75866	272873	79393284
Product prescribing error	1021.97	12.06	603	77628	44210	79621947
Systemic infection	658.59	12.06	275	77956	9477	79656680
Anaemia	550.01	12.06	1291	76940	443724	79222433
Product monitoring error	534.54	12.06	231	78000	8675	79657482
Haematochezia	528.49	12.06	534	77697	87111	79579046
Agranulocytosis	332.79	12.06	307	77924	44723	79621434
Drug ineffective	321.25	12.06	354	77877	1080559	78585598
Labelled drug-drug interaction medication error	291.18	12.06	231	78000	27419	79638738
Fracture	237.87	12.06	186	78045	21615	79644542

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N02BB02	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB52	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB72	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
CHEBI has role	CHEBI:35493	anti-pyretic
CHEBI has role	CHEBI:35842	anti-rheumatic drugs
CHEBI has role	CHEBI:49110	peripheral nervous system drugs
CHEBI has role	CHEBI:50266	Prodrugs
CHEBI has role	CHEBI:67079	anti-inflammatory agents
CHEBI has role	CHEBI:73263	cyclooxygenase-3 inhibitors
MeSH PA	D000700	Analgesics

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
Zimeta	Kindred Biosciences Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	0.21	acidic
pKa2	5.06	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Transient receptor potential cation channel subfamily A member 1	Ion channel	O75762	TRPA1_HUMAN	BLOCKER	IC50	4.04		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

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External reference:

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ID	Source
001609	NDDF
006029	NDDF
10608	IUPHAR_LIGAND_ID
1537943	RXNORM
22165008	SNOMEDCT_US
3111	PUBCHEM_CID
477	INN_ID
50567-35-6	SECONDARY_CAS_RN
51996-59-9	SECONDARY_CAS_RN
5907-38-0	SECONDARY_CAS_RN

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Pharmaceutical products:

None