Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory analgesics, phenylbutazone derivatives | 4659 | 68-89-3 |
Dose | Unit | Route |
---|---|---|
3 | g | O |
3 | g | P |
3 | g | R |
None
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 1349.59 | 12.44 | 1078 | 41667 | 168932 | 56080390 |
Product prescribing error | 569.20 | 12.44 | 300 | 42445 | 22886 | 56226436 |
Haematochezia | 317.22 | 12.44 | 264 | 42481 | 43454 | 56205868 |
Agranulocytosis | 283.89 | 12.44 | 190 | 42555 | 22469 | 56226853 |
Anaemia | 274.77 | 12.44 | 618 | 42127 | 266893 | 55982429 |
Product monitoring error | 273.99 | 12.44 | 102 | 42643 | 3357 | 56245965 |
Systemic infection | 246.56 | 12.44 | 93 | 42652 | 3176 | 56246146 |
Drug ineffective | 220.81 | 12.44 | 225 | 42520 | 918764 | 55330558 |
Fracture | 192.50 | 12.44 | 137 | 42608 | 17881 | 56231441 |
Haematemesis | 149.63 | 12.44 | 144 | 42601 | 28614 | 56220708 |
Polyneuropathy | 148.16 | 12.44 | 103 | 42642 | 12947 | 56236375 |
Rheumatoid arthritis | 141.34 | 12.44 | 57 | 42688 | 382547 | 55866775 |
Joint swelling | 141.13 | 12.44 | 25 | 42720 | 289775 | 55959547 |
Fall | 136.77 | 12.44 | 585 | 42160 | 356925 | 55892397 |
Aspirin-exacerbated respiratory disease | 131.81 | 12.44 | 42 | 42703 | 855 | 56248467 |
Labelled drug-drug interaction medication error | 125.83 | 12.44 | 89 | 42656 | 11497 | 56237825 |
Product dose omission issue | 112.98 | 12.44 | 12 | 42733 | 204741 | 56044581 |
Systemic lupus erythematosus | 112.18 | 12.44 | 6 | 42739 | 180072 | 56069250 |
Abdominal discomfort | 111.32 | 12.44 | 36 | 42709 | 277238 | 55972084 |
Leukopenia | 111.26 | 12.44 | 196 | 42549 | 70744 | 56178578 |
Infusion related reaction | 106.18 | 12.44 | 16 | 42729 | 208915 | 56040407 |
Synovitis | 104.96 | 12.44 | 4 | 42741 | 161301 | 56088021 |
Abdominal pain lower | 104.15 | 12.44 | 107 | 42638 | 22985 | 56226337 |
Pemphigus | 101.95 | 12.44 | 4 | 42741 | 157208 | 56092114 |
Treatment failure | 99.29 | 12.44 | 8 | 42737 | 170384 | 56078938 |
Pallor | 96.65 | 12.44 | 105 | 42640 | 24044 | 56225278 |
Restlessness | 90.06 | 12.44 | 106 | 42639 | 26480 | 56222842 |
Therapeutic product effect decreased | 88.36 | 12.44 | 12 | 42733 | 169440 | 56079882 |
Toxic epidermal necrolysis | 86.75 | 12.44 | 95 | 42650 | 21947 | 56227375 |
Dyspnoea | 84.73 | 12.44 | 751 | 41994 | 591826 | 55657496 |
Erysipelas | 84.38 | 12.44 | 58 | 42687 | 7155 | 56242167 |
Arthropathy | 83.96 | 12.44 | 24 | 42721 | 200251 | 56049071 |
Apathy | 83.83 | 12.44 | 60 | 42685 | 7894 | 56241428 |
Abdominal pain | 83.44 | 12.44 | 403 | 42342 | 258402 | 55990920 |
Swelling | 83.22 | 12.44 | 39 | 42706 | 239732 | 56009590 |
Drug intolerance | 83.18 | 12.44 | 49 | 42696 | 264769 | 55984553 |
Vomiting | 81.54 | 12.44 | 651 | 42094 | 497577 | 55751745 |
Product administration error | 80.28 | 12.44 | 89 | 42656 | 20840 | 56228482 |
Stevens-Johnson syndrome | 77.83 | 12.44 | 91 | 42654 | 22572 | 56226750 |
Sinusitis | 76.90 | 12.44 | 27 | 42718 | 197554 | 56051768 |
Arrhythmia | 75.57 | 12.44 | 112 | 42633 | 34971 | 56214351 |
Nausea | 74.28 | 12.44 | 895 | 41850 | 763283 | 55486039 |
Alopecia | 70.90 | 12.44 | 71 | 42674 | 293387 | 55955935 |
Abdominal pain upper | 70.43 | 12.44 | 295 | 42450 | 178018 | 56071304 |
Tachypnoea | 65.10 | 12.44 | 69 | 42676 | 15361 | 56233961 |
Pancytopenia | 64.42 | 12.44 | 180 | 42565 | 88535 | 56160787 |
Malaise | 64.39 | 12.44 | 113 | 42632 | 367747 | 55881575 |
Drug-induced liver injury | 64.37 | 12.44 | 103 | 42642 | 34359 | 56214963 |
Drug hypersensitivity | 63.75 | 12.44 | 69 | 42676 | 275136 | 55974186 |
Jaundice | 61.48 | 12.44 | 89 | 42656 | 27205 | 56222117 |
Pericarditis | 61.04 | 12.44 | 6 | 42739 | 108917 | 56140405 |
Renal impairment | 60.82 | 12.44 | 166 | 42579 | 80547 | 56168775 |
Electrolyte imbalance | 59.58 | 12.44 | 71 | 42674 | 17962 | 56231360 |
Haematoma | 58.84 | 12.44 | 95 | 42650 | 31924 | 56217398 |
Lower respiratory tract infection | 57.80 | 12.44 | 9 | 42736 | 114785 | 56134537 |
Upper gastrointestinal haemorrhage | 57.76 | 12.44 | 68 | 42677 | 16986 | 56232336 |
Product use issue | 56.18 | 12.44 | 36 | 42709 | 186005 | 56063317 |
Acute hepatic failure | 55.98 | 12.44 | 66 | 42679 | 16512 | 56232810 |
Maternal exposure during pregnancy | 55.46 | 12.44 | 38 | 42707 | 189515 | 56059807 |
Completed suicide | 54.31 | 12.44 | 17 | 42728 | 133816 | 56115506 |
Cardiac failure | 54.22 | 12.44 | 161 | 42584 | 81932 | 56167390 |
Musculoskeletal stiffness | 53.13 | 12.44 | 26 | 42719 | 155981 | 56093341 |
Gamma-glutamyltransferase increased | 52.95 | 12.44 | 89 | 42656 | 30916 | 56218406 |
Ascites | 52.81 | 12.44 | 99 | 42646 | 37445 | 56211877 |
Tachycardia | 52.23 | 12.44 | 188 | 42557 | 105688 | 56143634 |
Drug interaction | 50.73 | 12.44 | 302 | 42443 | 209453 | 56039869 |
Oedema peripheral | 50.38 | 12.44 | 260 | 42485 | 170994 | 56078328 |
Haemorrhagic erosive gastritis | 47.23 | 12.44 | 15 | 42730 | 302 | 56249020 |
Dysuria | 46.97 | 12.44 | 84 | 42661 | 30645 | 56218677 |
Osteochondrosis | 46.56 | 12.44 | 21 | 42724 | 1135 | 56248187 |
Contraindicated product administered | 46.18 | 12.44 | 44 | 42701 | 186242 | 56063080 |
Therapeutic drug monitoring analysis not performed | 46.09 | 12.44 | 20 | 42725 | 985 | 56248337 |
Hypokalaemia | 45.99 | 12.44 | 167 | 42578 | 94270 | 56155052 |
Malignant neoplasm progression | 45.47 | 12.44 | 141 | 42604 | 73446 | 56175876 |
Gastritis erosive | 45.29 | 12.44 | 36 | 42709 | 5541 | 56243781 |
Disturbance in attention | 44.77 | 12.44 | 85 | 42660 | 32455 | 56216867 |
Pyrexia | 44.67 | 12.44 | 500 | 42245 | 418273 | 55831049 |
Atrial fibrillation | 43.60 | 12.44 | 181 | 42564 | 108716 | 56140606 |
Arthralgia | 43.28 | 12.44 | 215 | 42530 | 501454 | 55747868 |
Nasopharyngitis | 43.20 | 12.44 | 63 | 42682 | 220896 | 56028426 |
Dehydration | 43.19 | 12.44 | 236 | 42509 | 158589 | 56090733 |
Nasal disorder | 43.17 | 12.44 | 26 | 42719 | 2556 | 56246766 |
Listless | 42.71 | 12.44 | 26 | 42719 | 2606 | 56246716 |
Syncope | 41.88 | 12.44 | 178 | 42567 | 108021 | 56141301 |
Concomitant disease aggravated | 41.57 | 12.44 | 41 | 42704 | 8385 | 56240937 |
Tumour pain | 41.30 | 12.44 | 20 | 42725 | 1271 | 56248051 |
Helicobacter infection | 41.14 | 12.44 | 4 | 42741 | 73264 | 56176058 |
Hepatorenal failure | 40.71 | 12.44 | 16 | 42729 | 611 | 56248711 |
Discomfort | 40.68 | 12.44 | 29 | 42716 | 141732 | 56107590 |
Stenosis | 40.67 | 12.44 | 20 | 42725 | 1314 | 56248008 |
Reduced facial expression | 40.55 | 12.44 | 22 | 42723 | 1774 | 56247548 |
Acute kidney injury | 39.96 | 12.44 | 316 | 42429 | 240447 | 56008875 |
Injection site pain | 39.15 | 12.44 | 20 | 42725 | 117098 | 56132224 |
Medication error | 39.05 | 12.44 | 94 | 42651 | 42241 | 56207081 |
Psoriasis | 39.01 | 12.44 | 11 | 42734 | 92681 | 56156641 |
Weight increased | 38.84 | 12.44 | 72 | 42673 | 229631 | 56019691 |
Cardiac failure congestive | 37.68 | 12.44 | 10 | 42735 | 87710 | 56161612 |
Subileus | 37.60 | 12.44 | 25 | 42720 | 2919 | 56246403 |
Product used for unknown indication | 37.32 | 12.44 | 16 | 42729 | 765 | 56248557 |
Dizziness | 36.91 | 12.44 | 442 | 42303 | 375698 | 55873624 |
Thrombocytopenia | 36.75 | 12.44 | 202 | 42543 | 136022 | 56113300 |
Rash | 36.64 | 12.44 | 222 | 42523 | 492825 | 55756497 |
Cachexia | 36.12 | 12.44 | 30 | 42715 | 4912 | 56244410 |
Suspected product quality issue | 35.63 | 12.44 | 11 | 42734 | 201 | 56249121 |
Pelvic fracture | 35.37 | 12.44 | 45 | 42700 | 12168 | 56237154 |
Hepatitis toxic | 35.15 | 12.44 | 24 | 42721 | 2928 | 56246394 |
Musculoskeletal pain | 34.95 | 12.44 | 138 | 42607 | 81014 | 56168308 |
Gallbladder polyp | 34.89 | 12.44 | 15 | 42730 | 722 | 56248600 |
Somatic symptom disorder | 34.78 | 12.44 | 21 | 42724 | 2074 | 56247248 |
Urogenital haemorrhage | 33.67 | 12.44 | 11 | 42734 | 243 | 56249079 |
Constipation | 33.46 | 12.44 | 265 | 42480 | 201678 | 56047644 |
Prescription drug used without a prescription | 33.27 | 12.44 | 20 | 42725 | 1960 | 56247362 |
Spinal pain | 33.17 | 12.44 | 43 | 42702 | 11841 | 56237481 |
Facial nerve disorder | 32.00 | 12.44 | 13 | 42732 | 542 | 56248780 |
Headache | 31.71 | 12.44 | 272 | 42473 | 558772 | 55690550 |
Type I hypersensitivity | 31.55 | 12.44 | 21 | 42724 | 2457 | 56246865 |
Therapeutic product effect incomplete | 31.33 | 12.44 | 21 | 42724 | 106010 | 56143312 |
Angina pectoris | 31.23 | 12.44 | 67 | 42678 | 27909 | 56221413 |
Hypersensitivity | 30.93 | 12.44 | 96 | 42649 | 256312 | 55993010 |
Ileus | 30.87 | 12.44 | 45 | 42700 | 13837 | 56235485 |
Delirium | 30.58 | 12.44 | 86 | 42659 | 42431 | 56206891 |
Gastrointestinal sounds abnormal | 29.70 | 12.44 | 24 | 42721 | 3781 | 56245541 |
Bicytopenia | 29.41 | 12.44 | 19 | 42726 | 2114 | 56247208 |
Nasal congestion | 29.34 | 12.44 | 4 | 42741 | 56366 | 56192956 |
Diverticulum intestinal | 29.32 | 12.44 | 30 | 42715 | 6410 | 56242912 |
Faecaloma | 29.15 | 12.44 | 32 | 42713 | 7409 | 56241913 |
Psychotic symptom | 28.78 | 12.44 | 16 | 42729 | 1353 | 56247969 |
Off label use | 28.75 | 12.44 | 277 | 42468 | 555903 | 55693419 |
Respiratory alkalosis | 28.63 | 12.44 | 20 | 42725 | 2531 | 56246791 |
Hyponatraemia | 28.57 | 12.44 | 153 | 42592 | 101986 | 56147336 |
Therapy non-responder | 28.31 | 12.44 | 6 | 42739 | 61349 | 56187973 |
Hospitalisation | 27.89 | 12.44 | 11 | 42734 | 74989 | 56174333 |
Injection site erythema | 27.76 | 12.44 | 12 | 42733 | 77436 | 56171886 |
Thirst | 27.69 | 12.44 | 38 | 42707 | 11052 | 56238270 |
Chromaturia | 27.51 | 12.44 | 45 | 42700 | 15280 | 56234042 |
Mucosal haemorrhage | 27.46 | 12.44 | 14 | 42731 | 994 | 56248328 |
Psoriatic arthropathy | 27.28 | 12.44 | 11 | 42734 | 73997 | 56175325 |
Muscle tone disorder | 27.20 | 12.44 | 8 | 42737 | 123 | 56249199 |
Nail toxicity | 26.66 | 12.44 | 10 | 42735 | 336 | 56248986 |
Gastrointestinal disorder | 26.34 | 12.44 | 28 | 42717 | 112674 | 56136648 |
Hypoaesthesia | 26.04 | 12.44 | 42 | 42703 | 141449 | 56107873 |
Post-traumatic pain | 25.74 | 12.44 | 10 | 42735 | 370 | 56248952 |
Immobile | 25.72 | 12.44 | 26 | 42719 | 5476 | 56243846 |
Vascular encephalopathy | 25.39 | 12.44 | 10 | 42735 | 384 | 56248938 |
Hepatic failure | 25.33 | 12.44 | 69 | 42676 | 33417 | 56215905 |
Thirst decreased | 25.31 | 12.44 | 9 | 42736 | 259 | 56249063 |
Heart rate increased | 25.27 | 12.44 | 16 | 42729 | 83257 | 56166065 |
Antineutrophil cytoplasmic antibody positive | 25.25 | 12.44 | 11 | 42734 | 547 | 56248775 |
Feeling abnormal | 25.21 | 12.44 | 39 | 42706 | 133563 | 56115759 |
Insomnia | 25.19 | 12.44 | 69 | 42676 | 191791 | 56057531 |
Blood pressure increased | 24.97 | 12.44 | 45 | 42700 | 145131 | 56104191 |
Acute generalised exanthematous pustulosis | 24.92 | 12.44 | 34 | 42711 | 9835 | 56239487 |
Hepatic enzyme increased | 24.53 | 12.44 | 59 | 42686 | 171325 | 56077997 |
Pseudarthrosis | 24.17 | 12.44 | 10 | 42735 | 437 | 56248885 |
Gastric mucosa erythema | 24.03 | 12.44 | 9 | 42736 | 301 | 56249021 |
Gastric ulcer | 24 | 12.44 | 53 | 42692 | 22510 | 56226812 |
Injury | 23.57 | 12.44 | 8 | 42737 | 59843 | 56189479 |
Drug reaction with eosinophilia and systemic symptoms | 23.48 | 12.44 | 63 | 42682 | 30241 | 56219081 |
Urinary retention | 23.42 | 12.44 | 60 | 42685 | 28014 | 56221308 |
Pleural effusion | 23.20 | 12.44 | 127 | 42618 | 85353 | 56163969 |
Injection site reaction | 23.00 | 12.44 | 6 | 42739 | 53241 | 56196081 |
Hepatitis acute | 22.95 | 12.44 | 30 | 42715 | 8327 | 56240995 |
Therapeutic response decreased | 22.68 | 12.44 | 6 | 42739 | 52752 | 56196570 |
Death | 22.64 | 12.44 | 159 | 42586 | 341267 | 55908055 |
Device stimulation issue | 22.58 | 12.44 | 6 | 42739 | 62 | 56249260 |
Head discomfort | 22.55 | 12.44 | 36 | 42709 | 11978 | 56237344 |
Lividity | 22.31 | 12.44 | 8 | 42737 | 236 | 56249086 |
Peripheral swelling | 22.30 | 12.44 | 97 | 42648 | 234629 | 56014693 |
Gastroenteritis | 22.29 | 12.44 | 54 | 42691 | 24358 | 56224964 |
Circulatory collapse | 22.28 | 12.44 | 49 | 42696 | 20754 | 56228568 |
Localised infection | 22.27 | 12.44 | 58 | 42687 | 27354 | 56221968 |
Foreign body | 22.25 | 12.44 | 16 | 42729 | 2120 | 56247202 |
Suspected product contamination | 21.98 | 12.44 | 5 | 42740 | 25 | 56249297 |
Dyspnoea exertional | 21.95 | 12.44 | 91 | 42654 | 54598 | 56194724 |
Lethargy | 21.83 | 12.44 | 6 | 42739 | 51435 | 56197887 |
Vasculitis | 21.79 | 12.44 | 40 | 42705 | 14883 | 56234439 |
Myocardial infarction | 21.78 | 12.44 | 23 | 42722 | 92847 | 56156475 |
Injection site pruritus | 21.76 | 12.44 | 3 | 42742 | 41928 | 56207394 |
Bradycardia | 21.59 | 12.44 | 105 | 42640 | 67399 | 56181923 |
Hepatic cyst | 21.23 | 12.44 | 22 | 42723 | 4771 | 56244551 |
Paresis | 21.20 | 12.44 | 16 | 42729 | 2282 | 56247040 |
Oliguria | 21.19 | 12.44 | 29 | 42716 | 8411 | 56240911 |
Hyperkinesia | 21.13 | 12.44 | 14 | 42731 | 1625 | 56247697 |
Adverse event | 20.79 | 12.44 | 8 | 42737 | 55368 | 56193954 |
Aortic valve stenosis | 20.74 | 12.44 | 18 | 42727 | 3129 | 56246193 |
Spontaneous haemorrhage | 20.67 | 12.44 | 8 | 42737 | 293 | 56249029 |
Vertigo | 20.50 | 12.44 | 89 | 42656 | 54483 | 56194839 |
Pain in jaw | 20.46 | 12.44 | 3 | 42742 | 40033 | 56209289 |
Amnesia | 20.43 | 12.44 | 5 | 42740 | 46317 | 56203005 |
Paranasal sinus inflammation | 20.41 | 12.44 | 9 | 42736 | 461 | 56248861 |
Liver function test increased | 20.32 | 12.44 | 57 | 42688 | 28076 | 56221246 |
Coombs negative haemolytic anaemia | 20.14 | 12.44 | 7 | 42738 | 188 | 56249134 |
Fluid intake reduced | 20.06 | 12.44 | 18 | 42727 | 3269 | 56246053 |
Acute abdomen | 19.98 | 12.44 | 13 | 42732 | 1463 | 56247859 |
Urosepsis | 19.78 | 12.44 | 41 | 42704 | 16675 | 56232647 |
Medication overuse headache | 19.73 | 12.44 | 10 | 42735 | 701 | 56248621 |
Ill-defined disorder | 19.68 | 12.44 | 14 | 42731 | 68529 | 56180793 |
Irritable bowel syndrome | 19.63 | 12.44 | 14 | 42731 | 68444 | 56180878 |
Transaminases increased | 19.53 | 12.44 | 57 | 42688 | 28713 | 56220609 |
Neuropathy peripheral | 19.44 | 12.44 | 30 | 42715 | 102863 | 56146459 |
Unevaluable event | 19.44 | 12.44 | 6 | 42739 | 47681 | 56201641 |
Cholestatic liver injury | 19.29 | 12.44 | 15 | 42730 | 2237 | 56247085 |
Pneumobilia | 19.07 | 12.44 | 6 | 42739 | 117 | 56249205 |
Decreased appetite | 19.04 | 12.44 | 252 | 42493 | 218979 | 56030343 |
Hypertensive emergency | 18.93 | 12.44 | 13 | 42732 | 1600 | 56247722 |
Peritoneal perforation | 18.93 | 12.44 | 6 | 42739 | 120 | 56249202 |
Left ventricular hypertrophy | 18.77 | 12.44 | 21 | 42724 | 4963 | 56244359 |
Necrotising fasciitis | 18.70 | 12.44 | 16 | 42729 | 2729 | 56246593 |
Duodenal ulcer | 18.60 | 12.44 | 25 | 42720 | 7130 | 56242192 |
Heart rate decreased | 18.56 | 12.44 | 4 | 42741 | 40423 | 56208899 |
Febrile infection | 18.32 | 12.44 | 12 | 42733 | 1366 | 56247956 |
Gastritis | 18.28 | 12.44 | 63 | 42682 | 34639 | 56214683 |
Chills | 18.28 | 12.44 | 137 | 42608 | 102467 | 56146855 |
Spinal osteoarthritis | 18.27 | 12.44 | 37 | 42708 | 14799 | 56234523 |
Stoma site inflammation | 18.12 | 12.44 | 8 | 42737 | 411 | 56248911 |
Sensory level abnormal | 18.10 | 12.44 | 6 | 42739 | 139 | 56249183 |
Inappropriate schedule of product administration | 18.08 | 12.44 | 22 | 42723 | 83365 | 56165957 |
Intentional product use issue | 17.98 | 12.44 | 30 | 42715 | 99703 | 56149619 |
No adverse event | 17.97 | 12.44 | 3 | 42742 | 36371 | 56212951 |
Nail avulsion | 17.90 | 12.44 | 6 | 42739 | 144 | 56249178 |
Haematuria | 17.87 | 12.44 | 53 | 42692 | 26934 | 56222388 |
Disease progression | 17.72 | 12.44 | 33 | 42712 | 105140 | 56144182 |
Sensory disturbance | 17.54 | 12.44 | 33 | 42712 | 12510 | 56236812 |
Depressed level of consciousness | 17.48 | 12.44 | 87 | 42658 | 56346 | 56192976 |
Metastatic malignant melanoma | 17.47 | 12.44 | 12 | 42733 | 1478 | 56247844 |
Peripheral circulatory failure | 17.38 | 12.44 | 10 | 42735 | 903 | 56248419 |
Patent ductus arteriosus | 17.25 | 12.44 | 18 | 42727 | 3933 | 56245389 |
Loss of personal independence in daily activities | 17.09 | 12.44 | 22 | 42723 | 81347 | 56167975 |
Cellulitis | 17.09 | 12.44 | 19 | 42726 | 74930 | 56174392 |
Faeces pale | 16.92 | 12.44 | 12 | 42733 | 1555 | 56247767 |
Affective disorder | 16.79 | 12.44 | 21 | 42724 | 5582 | 56243740 |
Anaemia folate deficiency | 16.36 | 12.44 | 6 | 42739 | 189 | 56249133 |
Urogenital infection bacterial | 16.20 | 12.44 | 4 | 42741 | 30 | 56249292 |
Internal haemorrhage | 16.14 | 12.44 | 19 | 42726 | 4745 | 56244577 |
Electrocardiogram abnormal | 16.11 | 12.44 | 25 | 42720 | 8119 | 56241203 |
Dyschezia | 16.08 | 12.44 | 13 | 42732 | 2050 | 56247272 |
Leukocytosis | 16.01 | 12.44 | 47 | 42698 | 23744 | 56225578 |
Neutropenia | 15.95 | 12.44 | 187 | 42558 | 157980 | 56091342 |
Brain contusion | 15.94 | 12.44 | 8 | 42737 | 549 | 56248773 |
Peripheral arterial occlusive disease | 15.85 | 12.44 | 17 | 42728 | 3833 | 56245489 |
Painful respiration | 15.81 | 12.44 | 14 | 42731 | 2500 | 56246822 |
Merycism | 15.76 | 12.44 | 6 | 42739 | 210 | 56249112 |
Hyperaemia | 15.76 | 12.44 | 13 | 42732 | 2109 | 56247213 |
Migraine | 15.74 | 12.44 | 26 | 42719 | 86771 | 56162551 |
Pregnancy | 15.72 | 12.44 | 3 | 42742 | 33030 | 56216292 |
C-reactive protein increased | 15.71 | 12.44 | 108 | 42637 | 78576 | 56170746 |
Type 2 diabetes mellitus | 15.65 | 12.44 | 8 | 42737 | 46854 | 56202468 |
Knee arthroplasty | 15.63 | 12.44 | 7 | 42738 | 44252 | 56205070 |
Flank pain | 15.63 | 12.44 | 34 | 42711 | 14291 | 56235031 |
Hyperglycaemia | 15.59 | 12.44 | 64 | 42681 | 38217 | 56211105 |
Contusion | 15.53 | 12.44 | 48 | 42697 | 128382 | 56120940 |
Lumbar vertebral fracture | 15.51 | 12.44 | 19 | 42726 | 4945 | 56244377 |
Pulmonary vein occlusion | 15.50 | 12.44 | 5 | 42740 | 106 | 56249216 |
Conjunctivitis | 15.48 | 12.44 | 39 | 42706 | 18021 | 56231301 |
Arthritis | 15.39 | 12.44 | 33 | 42712 | 99819 | 56149503 |
Urinary tract infection enterococcal | 15.36 | 12.44 | 14 | 42731 | 2595 | 56246727 |
VIIIth nerve injury | 15.26 | 12.44 | 3 | 42742 | 6 | 56249316 |
Cardiac murmur functional | 15.17 | 12.44 | 4 | 42741 | 40 | 56249282 |
Abdominal wall cyst | 15.00 | 12.44 | 4 | 42741 | 42 | 56249280 |
Bulimia nervosa | 14.88 | 12.44 | 7 | 42738 | 417 | 56248905 |
Kyphosis | 14.83 | 12.44 | 13 | 42732 | 2289 | 56247033 |
Reticulocyte count increased | 14.63 | 12.44 | 9 | 42736 | 919 | 56248403 |
Prerenal failure | 14.61 | 12.44 | 11 | 42734 | 1564 | 56247758 |
Hepatitis cholestatic | 14.56 | 12.44 | 21 | 42724 | 6393 | 56242929 |
Exposure during pregnancy | 14.41 | 12.44 | 54 | 42691 | 136288 | 56113034 |
Necrolytic migratory erythema | 14.40 | 12.44 | 3 | 42742 | 9 | 56249313 |
Angioedema | 14.36 | 12.44 | 66 | 42679 | 41387 | 56207935 |
Dysphagia | 14.35 | 12.44 | 109 | 42636 | 81838 | 56167484 |
Adverse drug reaction | 14.32 | 12.44 | 17 | 42728 | 65115 | 56184207 |
Petechiae | 14.29 | 12.44 | 31 | 42714 | 13008 | 56236314 |
Coronavirus test positive | 14.28 | 12.44 | 8 | 42737 | 687 | 56248635 |
Myoclonus | 14.28 | 12.44 | 34 | 42711 | 15169 | 56234153 |
Shock haemorrhagic | 14.20 | 12.44 | 25 | 42720 | 9008 | 56240314 |
Lordosis | 14.17 | 12.44 | 6 | 42739 | 278 | 56249044 |
Autoimmune colitis | 13.93 | 12.44 | 7 | 42738 | 482 | 56248840 |
Gastrointestinal infection | 13.93 | 12.44 | 23 | 42722 | 7871 | 56241451 |
Mucosal dryness | 13.92 | 12.44 | 13 | 42732 | 2485 | 56246837 |
Cardio-respiratory arrest | 13.77 | 12.44 | 13 | 42732 | 55308 | 56194014 |
Metastatic gastric cancer | 13.77 | 12.44 | 5 | 42740 | 153 | 56249169 |
Sinobronchitis | 13.68 | 12.44 | 5 | 42740 | 156 | 56249166 |
Bone marrow oedema | 13.58 | 12.44 | 9 | 42736 | 1045 | 56248277 |
Cerebrovascular accident | 13.55 | 12.44 | 35 | 42710 | 99235 | 56150087 |
CD8 lymphocytes decreased | 13.50 | 12.44 | 5 | 42740 | 162 | 56249160 |
Chronic fatigue syndrome | 13.50 | 12.44 | 9 | 42736 | 1056 | 56248266 |
Surgery | 13.40 | 12.44 | 4 | 42741 | 32482 | 56216840 |
Fatigue | 13.27 | 12.44 | 478 | 42267 | 788074 | 55461248 |
Upper respiratory tract infection | 13.26 | 12.44 | 21 | 42724 | 71267 | 56178055 |
Hyperresponsive to stimuli | 13.23 | 12.44 | 4 | 42741 | 68 | 56249254 |
Gastrointestinal tract adenoma | 13.17 | 12.44 | 6 | 42739 | 332 | 56248990 |
Systemic inflammatory response syndrome | 13.05 | 12.44 | 18 | 42727 | 5260 | 56244062 |
Ileus paralytic | 13.01 | 12.44 | 16 | 42729 | 4179 | 56245143 |
Rheumatic fever | 12.93 | 12.44 | 3 | 42742 | 28824 | 56220498 |
Unresponsive to stimuli | 12.91 | 12.44 | 4 | 42741 | 31721 | 56217601 |
Piloerection | 12.79 | 12.44 | 6 | 42739 | 355 | 56248967 |
Cancer fatigue | 12.76 | 12.44 | 4 | 42741 | 77 | 56249245 |
Gastric ulcer perforation | 12.65 | 12.44 | 9 | 42736 | 1172 | 56248150 |
Peripheral nerve lesion | 12.65 | 12.44 | 6 | 42739 | 364 | 56248958 |
Ileal stenosis | 12.60 | 12.44 | 10 | 42735 | 1535 | 56247787 |
Normochromic normocytic anaemia | 12.55 | 12.44 | 16 | 42729 | 4333 | 56244989 |
Substance dependence | 12.53 | 12.44 | 5 | 42740 | 199 | 56249123 |
Acute myocardial infarction | 12.53 | 12.44 | 51 | 42694 | 30342 | 56218980 |
Flatulence | 12.50 | 12.44 | 52 | 42693 | 31236 | 56218086 |
Dysplasia | 12.50 | 12.44 | 8 | 42737 | 876 | 56248446 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 1353.51 | 13.84 | 1041 | 32041 | 112394 | 31551868 |
Product prescribing error | 342.39 | 13.84 | 228 | 32854 | 19414 | 31644848 |
Systemic infection | 209.89 | 13.84 | 92 | 32990 | 3357 | 31660905 |
Haematochezia | 174.33 | 13.84 | 213 | 32869 | 40251 | 31624011 |
Anaemia | 156.99 | 13.84 | 534 | 32548 | 212988 | 31451274 |
Product monitoring error | 156.72 | 13.84 | 74 | 33008 | 3216 | 31661046 |
Drug ineffective | 152.22 | 13.84 | 115 | 32967 | 395458 | 31268804 |
Abdominal pain | 114.11 | 13.84 | 373 | 32709 | 145579 | 31518683 |
Death | 95.78 | 13.84 | 143 | 32939 | 360426 | 31303836 |
Musculoskeletal pain | 91.42 | 13.84 | 133 | 32949 | 29695 | 31634567 |
Appendicolith | 91.36 | 13.84 | 63 | 33019 | 5668 | 31658594 |
Agranulocytosis | 86.86 | 13.84 | 109 | 32973 | 21138 | 31643124 |
Completed suicide | 82.26 | 13.84 | 3 | 33079 | 91511 | 31572751 |
Abdominal pain upper | 77.75 | 13.84 | 192 | 32890 | 63810 | 31600452 |
Pallor | 76.12 | 13.84 | 105 | 32977 | 22319 | 31641943 |
Vomiting | 74.63 | 13.84 | 443 | 32639 | 223530 | 31440732 |
Leukopenia | 74.00 | 13.84 | 177 | 32905 | 57651 | 31606611 |
Nausea | 68.77 | 13.84 | 552 | 32530 | 307395 | 31356867 |
Cardiac failure congestive | 66.83 | 13.84 | 4 | 33078 | 79383 | 31584879 |
Labelled drug-drug interaction medication error | 66.09 | 13.84 | 75 | 33007 | 13088 | 31651174 |
Appendicitis | 65.67 | 13.84 | 70 | 33012 | 11395 | 31652867 |
Malaise | 64.50 | 13.84 | 49 | 33033 | 168462 | 31495800 |
Tachypnoea | 61.76 | 13.84 | 81 | 33001 | 16402 | 31647860 |
Product dose omission issue | 61.56 | 13.84 | 17 | 33065 | 105569 | 31558693 |
Micturition disorder | 59.10 | 13.84 | 33 | 33049 | 2040 | 31662222 |
Fracture | 56.16 | 13.84 | 49 | 33033 | 6231 | 31658031 |
Electrolyte imbalance | 55.60 | 13.84 | 66 | 33016 | 12082 | 31652180 |
Acute abdomen | 55.00 | 13.84 | 30 | 33052 | 1771 | 31662491 |
Tachycardia | 53.44 | 13.84 | 188 | 32894 | 76019 | 31588243 |
Constipation | 52.48 | 13.84 | 262 | 32820 | 123729 | 31540533 |
Dyspnoea | 51.64 | 13.84 | 566 | 32516 | 342913 | 31321349 |
Neuropathy peripheral | 44.41 | 13.84 | 12 | 33070 | 75637 | 31588625 |
Paresis | 44.38 | 13.84 | 27 | 33055 | 1960 | 31662302 |
Negative pressure pulmonary oedema | 43.59 | 13.84 | 14 | 33068 | 209 | 31664053 |
Dyschezia | 43.55 | 13.84 | 23 | 33059 | 1272 | 31662990 |
Blood pressure measurement | 42.41 | 13.84 | 13 | 33069 | 165 | 31664097 |
Electrocardiogram abnormal | 40.70 | 13.84 | 46 | 33036 | 7990 | 31656272 |
Restlessness | 40.68 | 13.84 | 81 | 33001 | 23280 | 31640982 |
Neuromuscular block prolonged | 40.49 | 13.84 | 16 | 33066 | 447 | 31663815 |
Pyrexia | 39.92 | 13.84 | 488 | 32594 | 303352 | 31360910 |
Polyneuropathy | 39.78 | 13.84 | 58 | 33024 | 12964 | 31651298 |
Myocardial infarction | 39.65 | 13.84 | 36 | 33046 | 113418 | 31550844 |
Hyponatraemia | 38.61 | 13.84 | 166 | 32916 | 73633 | 31590629 |
Toxicity to various agents | 38.10 | 13.84 | 83 | 32999 | 181404 | 31482858 |
Oedema peripheral | 37.56 | 13.84 | 219 | 32863 | 109620 | 31554642 |
Mucosal haemorrhage | 36.97 | 13.84 | 22 | 33060 | 1534 | 31662728 |
Disturbance in attention | 36.90 | 13.84 | 76 | 33006 | 22374 | 31641888 |
C-reactive protein increased | 36.68 | 13.84 | 123 | 32959 | 48527 | 31615735 |
Abdominal distension | 36.34 | 13.84 | 126 | 32956 | 50558 | 31613704 |
Blood phosphorus increased | 36.16 | 13.84 | 33 | 33049 | 4449 | 31659813 |
Therapeutic drug monitoring analysis not performed | 35.62 | 13.84 | 15 | 33067 | 495 | 31663767 |
Cachexia | 35.14 | 13.84 | 39 | 33043 | 6640 | 31657622 |
Malignant neoplasm progression | 34.86 | 13.84 | 169 | 32913 | 78829 | 31585433 |
Impaired healing | 34.83 | 13.84 | 57 | 33025 | 14075 | 31650187 |
Platelet dysfunction | 34.39 | 13.84 | 12 | 33070 | 234 | 31664028 |
Product administration error | 34.26 | 13.84 | 59 | 33023 | 15188 | 31649074 |
Fall | 33.75 | 13.84 | 319 | 32763 | 185770 | 31478492 |
Interstitial lung disease | 33.74 | 13.84 | 11 | 33071 | 61392 | 31602870 |
Gamma-glutamyltransferase increased | 33.25 | 13.84 | 83 | 32999 | 27742 | 31636520 |
Hospitalisation | 33.06 | 13.84 | 6 | 33076 | 49801 | 31614461 |
Ventricular fibrillation | 32.39 | 13.84 | 65 | 33017 | 18783 | 31645479 |
Treatment failure | 31.64 | 13.84 | 3 | 33079 | 40789 | 31623473 |
Medication error | 31.61 | 13.84 | 72 | 33010 | 22700 | 31641562 |
Platelet count decreased | 30.94 | 13.84 | 42 | 33040 | 110393 | 31553869 |
Drug abuse | 30.47 | 13.84 | 28 | 33054 | 87730 | 31576532 |
Stress | 30.43 | 13.84 | 75 | 33007 | 24866 | 31639396 |
Wound | 30.33 | 13.84 | 51 | 33031 | 12877 | 31651385 |
Cardiogenic shock | 30.16 | 13.84 | 70 | 33012 | 22338 | 31641924 |
Hypertensive crisis | 30.07 | 13.84 | 40 | 33042 | 8207 | 31656055 |
Weight bearing difficulty | 29.45 | 13.84 | 16 | 33066 | 937 | 31663325 |
Respiratory tract haemorrhage | 29.25 | 13.84 | 17 | 33065 | 1134 | 31663128 |
Leptotrichia infection | 28.29 | 13.84 | 8 | 33074 | 75 | 31664187 |
Drug reaction with eosinophilia and systemic symptoms | 28.27 | 13.84 | 82 | 33000 | 29936 | 31634326 |
Blood pressure increased | 28.13 | 13.84 | 25 | 33057 | 79608 | 31584654 |
Internal fixation of fracture | 27.57 | 13.84 | 8 | 33074 | 83 | 31664179 |
Infusion related reaction | 27.50 | 13.84 | 8 | 33074 | 48047 | 31616215 |
Accessory spleen | 27.45 | 13.84 | 9 | 33073 | 144 | 31664118 |
Toxic epidermal necrolysis | 27.39 | 13.84 | 62 | 33020 | 19462 | 31644800 |
Ascites | 26.86 | 13.84 | 99 | 32983 | 40914 | 31623348 |
Feeling abnormal | 26.75 | 13.84 | 13 | 33069 | 56989 | 31607273 |
Erysipelas | 26.63 | 13.84 | 28 | 33054 | 4485 | 31659777 |
Dizziness | 26.56 | 13.84 | 321 | 32761 | 198826 | 31465436 |
Haematemesis | 26.03 | 13.84 | 72 | 33010 | 25581 | 31638681 |
Cardiac arrest | 25.83 | 13.84 | 33 | 33049 | 89029 | 31575233 |
Gastrointestinal adenocarcinoma | 25.63 | 13.84 | 7 | 33075 | 57 | 31664205 |
Disease progression | 24.74 | 13.84 | 35 | 33047 | 90429 | 31573833 |
Suspected product contamination | 24.63 | 13.84 | 7 | 33075 | 67 | 31664195 |
Hydrocholecystis | 24.30 | 13.84 | 10 | 33072 | 311 | 31663951 |
Hyperventilation | 23.34 | 13.84 | 20 | 33062 | 2481 | 31661781 |
Urosepsis | 23.30 | 13.84 | 43 | 33039 | 11677 | 31652585 |
Multiple organ dysfunction syndrome | 23.29 | 13.84 | 136 | 32946 | 68067 | 31596195 |
Thrombosis | 23.25 | 13.84 | 9 | 33073 | 45142 | 31619120 |
Iris adhesions | 23.20 | 13.84 | 9 | 33073 | 239 | 31664023 |
Pain | 23.16 | 13.84 | 297 | 32785 | 186462 | 31477800 |
Condition aggravated | 23.01 | 13.84 | 267 | 32815 | 163742 | 31500520 |
Psoriasis | 22.94 | 13.84 | 10 | 33072 | 46709 | 31617553 |
Therapeutic product effect decreased | 22.82 | 13.84 | 3 | 33079 | 31619 | 31632643 |
Haematoma | 22.78 | 13.84 | 66 | 33016 | 24073 | 31640189 |
Cold sweat | 22.50 | 13.84 | 37 | 33045 | 9172 | 31655090 |
Joint swelling | 22.44 | 13.84 | 14 | 33068 | 53417 | 31610845 |
Long QT syndrome | 22.31 | 13.84 | 19 | 33063 | 2337 | 31661925 |
Hepatorenal failure | 22.17 | 13.84 | 11 | 33071 | 533 | 31663729 |
Depressed level of consciousness | 21.87 | 13.84 | 89 | 32993 | 38512 | 31625750 |
Implant site inflammation | 21.76 | 13.84 | 7 | 33075 | 105 | 31664157 |
Tension headache | 21.29 | 13.84 | 15 | 33067 | 1396 | 31662866 |
Abdominal discomfort | 20.99 | 13.84 | 14 | 33068 | 51553 | 31612709 |
Adenocarcinoma of appendix | 20.96 | 13.84 | 7 | 33075 | 119 | 31664143 |
Intestinal haemorrhage | 20.57 | 13.84 | 21 | 33061 | 3250 | 31661012 |
Contraindicated product administered | 20.56 | 13.84 | 56 | 33026 | 19716 | 31644546 |
Therapy non-responder | 20.53 | 13.84 | 5 | 33077 | 33806 | 31630456 |
Angioedema | 20.23 | 13.84 | 79 | 33003 | 33539 | 31630723 |
Cardiovascular insufficiency | 20.17 | 13.84 | 15 | 33067 | 1519 | 31662743 |
Labelled drug-drug interaction issue | 20.16 | 13.84 | 8 | 33074 | 226 | 31664036 |
Pseudarthrosis | 19.73 | 13.84 | 6 | 33076 | 74 | 31664188 |
Product prescribing issue | 19.68 | 13.84 | 15 | 33067 | 1576 | 31662686 |
Osteochondrosis | 19.57 | 13.84 | 12 | 33070 | 883 | 31663379 |
Suspected product quality issue | 19.45 | 13.84 | 7 | 33075 | 150 | 31664112 |
Thirst | 19.33 | 13.84 | 29 | 33053 | 6647 | 31657615 |
Tracheal atresia | 19.08 | 13.84 | 4 | 33078 | 8 | 31664254 |
Mineral supplementation | 19.04 | 13.84 | 6 | 33076 | 84 | 31664178 |
Lack of application site rotation | 18.76 | 13.84 | 4 | 33078 | 9 | 31664253 |
Spinal pain | 18.64 | 13.84 | 25 | 33057 | 5170 | 31659092 |
Pulmonary sepsis | 18.59 | 13.84 | 16 | 33066 | 1996 | 31662266 |
Coma | 18.39 | 13.84 | 10 | 33072 | 41140 | 31623122 |
Immobile | 18.31 | 13.84 | 17 | 33065 | 2343 | 31661919 |
Febrile infection | 18.25 | 13.84 | 16 | 33066 | 2046 | 31662216 |
Genitourinary tract infection | 18.18 | 13.84 | 6 | 33076 | 98 | 31664164 |
Chronic fatigue syndrome | 18.09 | 13.84 | 8 | 33074 | 298 | 31663964 |
Hepatic cyst | 18.08 | 13.84 | 17 | 33065 | 2381 | 31661881 |
Dysdiadochokinesis | 17.83 | 13.84 | 7 | 33075 | 192 | 31664070 |
Platelet function test abnormal | 17.75 | 13.84 | 6 | 33076 | 106 | 31664156 |
Unevaluable event | 17.65 | 13.84 | 5 | 33077 | 30570 | 31633692 |
Heart rate decreased | 17.52 | 13.84 | 4 | 33078 | 28262 | 31636000 |
Unresponsive to stimuli | 17.35 | 13.84 | 3 | 33079 | 25797 | 31638465 |
Flushing | 17.26 | 13.84 | 5 | 33077 | 30123 | 31634139 |
Adrenocortical insufficiency acute | 17.25 | 13.84 | 13 | 33069 | 1343 | 31662919 |
Autoimmune nephritis | 17.21 | 13.84 | 7 | 33075 | 211 | 31664051 |
Musculoskeletal stiffness | 17.12 | 13.84 | 11 | 33071 | 41314 | 31622948 |
Vertigo | 17.06 | 13.84 | 58 | 33024 | 23027 | 31641235 |
Gastritis haemorrhagic | 17.00 | 13.84 | 13 | 33069 | 1372 | 31662890 |
Toxic neuropathy | 16.97 | 13.84 | 9 | 33073 | 502 | 31663760 |
Flank pain | 16.93 | 13.84 | 26 | 33056 | 6083 | 31658179 |
Urogenital infection bacterial | 16.88 | 13.84 | 5 | 33077 | 56 | 31664206 |
Cardiac disorder | 16.85 | 13.84 | 10 | 33072 | 39204 | 31625058 |
Anxiety disorder | 16.73 | 13.84 | 14 | 33068 | 1681 | 31662581 |
Reflux nephropathy | 16.65 | 13.84 | 5 | 33077 | 59 | 31664203 |
Drug intolerance | 16.45 | 13.84 | 18 | 33064 | 52015 | 31612247 |
Tonsillitis | 16.11 | 13.84 | 15 | 33067 | 2075 | 31662187 |
Blood folate increased | 16.08 | 13.84 | 7 | 33075 | 251 | 31664011 |
Paraparesis | 15.96 | 13.84 | 14 | 33068 | 1792 | 31662470 |
Spinal cord injury cauda equina | 15.96 | 13.84 | 6 | 33076 | 146 | 31664116 |
White blood cell count decreased | 15.91 | 13.84 | 43 | 33039 | 87355 | 31576907 |
Orthostatic hypotension | 15.80 | 13.84 | 3 | 33079 | 24116 | 31640146 |
Lung disorder | 15.73 | 13.84 | 7 | 33075 | 32305 | 31631957 |
Jaundice | 15.72 | 13.84 | 68 | 33014 | 30219 | 31634043 |
Cardiovascular disorder | 15.70 | 13.84 | 32 | 33050 | 9346 | 31654916 |
Somatosensory evoked potentials abnormal | 15.66 | 13.84 | 6 | 33076 | 154 | 31664108 |
Loss of personal independence in daily activities | 15.65 | 13.84 | 5 | 33077 | 28283 | 31635979 |
Influenza | 15.54 | 13.84 | 14 | 33068 | 44311 | 31619951 |
Breath sounds normal | 15.52 | 13.84 | 3 | 33079 | 3 | 31664259 |
Swelling | 15.40 | 13.84 | 10 | 33072 | 37348 | 31626914 |
Cerebrovascular accident | 15.32 | 13.84 | 38 | 33044 | 79446 | 31584816 |
Thrombocytopenia | 15.21 | 13.84 | 221 | 32861 | 142526 | 31521736 |
Drug resistance | 15.19 | 13.84 | 3 | 33079 | 23450 | 31640812 |
Disorientation | 15.18 | 13.84 | 68 | 33014 | 30676 | 31633586 |
Nail bed inflammation | 15.14 | 13.84 | 6 | 33076 | 169 | 31664093 |
Haemorrhagic necrotic pancreatitis | 15.10 | 13.84 | 6 | 33076 | 170 | 31664092 |
Lower gastrointestinal haemorrhage | 14.97 | 13.84 | 30 | 33052 | 8659 | 31655603 |
Anxiety | 14.97 | 13.84 | 47 | 33035 | 90986 | 31573276 |
Fear of disease | 14.93 | 13.84 | 7 | 33075 | 299 | 31663963 |
Oedematous pancreatitis | 14.86 | 13.84 | 8 | 33074 | 460 | 31663802 |
Coronavirus test positive | 14.75 | 13.84 | 8 | 33074 | 467 | 31663795 |
Vitamin B6 deficiency | 14.69 | 13.84 | 6 | 33076 | 183 | 31664079 |
Rectal haemorrhage | 14.58 | 13.84 | 10 | 33072 | 36294 | 31627968 |
Food interaction | 14.52 | 13.84 | 10 | 33072 | 897 | 31663365 |
Mycobacterium fortuitum infection | 14.48 | 13.84 | 6 | 33076 | 190 | 31664072 |
Product packaging confusion | 14.39 | 13.84 | 4 | 33078 | 35 | 31664227 |
Upper gastrointestinal haemorrhage | 14.37 | 13.84 | 55 | 33027 | 23128 | 31641134 |
Primary biliary cholangitis | 14.27 | 13.84 | 6 | 33076 | 197 | 31664065 |
Autoimmune hepatitis | 14.27 | 13.84 | 19 | 33063 | 3901 | 31660361 |
Fear of falling | 14.27 | 13.84 | 7 | 33075 | 331 | 31663931 |
Anal haemorrhage | 14.26 | 13.84 | 15 | 33067 | 2403 | 31661859 |
Preternatural anus | 14.21 | 13.84 | 5 | 33077 | 100 | 31664162 |
Psychotic disorder | 14.13 | 13.84 | 3 | 33079 | 22290 | 31641972 |
Renal impairment | 14.13 | 13.84 | 145 | 32937 | 86204 | 31578058 |
Therapeutic response decreased | 14.12 | 13.84 | 5 | 33077 | 26504 | 31637758 |
Seizure | 14.06 | 13.84 | 55 | 33027 | 99713 | 31564549 |
Target skin lesion | 13.99 | 13.84 | 3 | 33079 | 7 | 31664255 |
Respiratory arrest | 13.91 | 13.84 | 5 | 33077 | 26252 | 31638010 |
Oral herpes | 13.87 | 13.84 | 21 | 33061 | 4852 | 31659410 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 2666.88 | 12.06 | 2030 | 66246 | 234001 | 70626167 |
Product prescribing error | 883.97 | 12.06 | 519 | 67757 | 38433 | 70821735 |
Haematochezia | 480.90 | 12.06 | 463 | 67813 | 72618 | 70787550 |
Systemic infection | 443.76 | 12.06 | 185 | 68091 | 6472 | 70853696 |
Anaemia | 436.34 | 12.06 | 1099 | 67177 | 402324 | 70457844 |
Product monitoring error | 410.69 | 12.06 | 176 | 68100 | 6600 | 70853568 |
Agranulocytosis | 304.77 | 12.06 | 276 | 68000 | 40022 | 70820146 |
Drug ineffective | 271.77 | 12.06 | 304 | 67972 | 939448 | 69920720 |
Fracture | 235.56 | 12.06 | 177 | 68099 | 19767 | 70840401 |
Labelled drug-drug interaction medication error | 179.93 | 12.06 | 164 | 68112 | 23963 | 70836205 |
Pallor | 174.17 | 12.06 | 206 | 68070 | 40768 | 70819400 |
Abdominal pain | 171.27 | 12.06 | 717 | 67559 | 341410 | 70518758 |
Leukopenia | 156.22 | 12.06 | 328 | 67948 | 106232 | 70753936 |
Haematemesis | 156.17 | 12.06 | 213 | 68063 | 48584 | 70811584 |
Completed suicide | 153.52 | 12.06 | 19 | 68257 | 227116 | 70633052 |
Vomiting | 149.64 | 12.06 | 1029 | 67247 | 592082 | 70268086 |
Joint swelling | 143.09 | 12.06 | 34 | 68242 | 253177 | 70606991 |
Nausea | 140.47 | 12.06 | 1341 | 66935 | 850747 | 70009421 |
Abdominal pain upper | 138.93 | 12.06 | 456 | 67820 | 193146 | 70667022 |
Fall | 137.54 | 12.06 | 812 | 67464 | 443284 | 70416884 |
Aspirin-exacerbated respiratory disease | 135.21 | 12.06 | 49 | 68227 | 1166 | 70859002 |
Malaise | 134.74 | 12.06 | 131 | 68145 | 432801 | 70427367 |
Restlessness | 131.96 | 12.06 | 182 | 68094 | 41946 | 70818222 |
Dyspnoea | 130.83 | 12.06 | 1220 | 67056 | 768840 | 70091328 |
Tachypnoea | 130.09 | 12.06 | 149 | 68127 | 28489 | 70831679 |
Polyneuropathy | 128.27 | 12.06 | 129 | 68147 | 21286 | 70838882 |
Product dose omission issue | 127.28 | 12.06 | 27 | 68249 | 217441 | 70642727 |
Product administration error | 119.82 | 12.06 | 145 | 68131 | 29378 | 70830790 |
Infusion related reaction | 118.77 | 12.06 | 23 | 68253 | 197511 | 70662657 |
Musculoskeletal pain | 118.62 | 12.06 | 266 | 68010 | 90061 | 70770107 |
Rheumatoid arthritis | 116.77 | 12.06 | 68 | 68208 | 291737 | 70568431 |
Electrolyte imbalance | 112.41 | 12.06 | 134 | 68142 | 26727 | 70833441 |
Abdominal discomfort | 109.70 | 12.06 | 35 | 68241 | 214623 | 70645545 |
Tachycardia | 103.60 | 12.06 | 362 | 67914 | 158184 | 70701984 |
Treatment failure | 102.57 | 12.06 | 10 | 68266 | 144132 | 70716036 |
Synovitis | 100.31 | 12.06 | 6 | 68270 | 129222 | 70730946 |
Constipation | 94.31 | 12.06 | 486 | 67790 | 251952 | 70608216 |
Therapeutic product effect decreased | 94.11 | 12.06 | 13 | 68263 | 143005 | 70717163 |
Appendicolith | 94.05 | 12.06 | 62 | 68214 | 5618 | 70854550 |
Arthropathy | 93.36 | 12.06 | 16 | 68260 | 150041 | 70710127 |
Toxic epidermal necrolysis | 91.09 | 12.06 | 148 | 68128 | 39409 | 70820759 |
Cardiac failure congestive | 87.52 | 12.06 | 13 | 68263 | 135444 | 70724724 |
Sinusitis | 87.48 | 12.06 | 27 | 68249 | 169168 | 70691000 |
Oedema peripheral | 86.48 | 12.06 | 441 | 67835 | 227650 | 70632518 |
Erysipelas | 83.01 | 12.06 | 72 | 68204 | 9852 | 70850316 |
Pyrexia | 82.34 | 12.06 | 919 | 67357 | 606033 | 70254135 |
Disturbance in attention | 81.03 | 12.06 | 147 | 68129 | 42747 | 70817421 |
Drug intolerance | 80.23 | 12.06 | 60 | 68216 | 225627 | 70634541 |
Musculoskeletal stiffness | 79.28 | 12.06 | 22 | 68254 | 147738 | 70712430 |
Abdominal pain lower | 78.18 | 12.06 | 115 | 68161 | 28101 | 70832067 |
Swelling | 78.16 | 12.06 | 42 | 68234 | 188497 | 70671671 |
Therapeutic drug monitoring analysis not performed | 77.06 | 12.06 | 35 | 68241 | 1509 | 70858659 |
Lower respiratory tract infection | 74.03 | 12.06 | 10 | 68266 | 111903 | 70748265 |
Medication error | 74.01 | 12.06 | 167 | 68109 | 56745 | 70803423 |
Gamma-glutamyltransferase increased | 70.74 | 12.06 | 153 | 68123 | 50532 | 70809636 |
Renal impairment | 70.50 | 12.06 | 300 | 67976 | 143637 | 70716531 |
Injection site pain | 70.03 | 12.06 | 14 | 68262 | 117605 | 70742563 |
Jaundice | 69.64 | 12.06 | 151 | 68125 | 49957 | 70810211 |
Ascites | 69.43 | 12.06 | 181 | 68095 | 67366 | 70792802 |
Cachexia | 69.35 | 12.06 | 65 | 68211 | 9835 | 70850333 |
Malignant neoplasm progression | 68.58 | 12.06 | 265 | 68011 | 121474 | 70738694 |
Blood pressure increased | 68.44 | 12.06 | 49 | 68227 | 188468 | 70671700 |
Haematoma | 67.39 | 12.06 | 146 | 68130 | 48272 | 70811896 |
Pemphigus | 63.99 | 12.06 | 4 | 68272 | 83032 | 70777136 |
Paresis | 63.48 | 12.06 | 42 | 68234 | 3828 | 70856340 |
Dehydration | 62.52 | 12.06 | 402 | 67874 | 225740 | 70634428 |
Acute abdomen | 61.49 | 12.06 | 37 | 68239 | 2857 | 70857311 |
Death | 61.10 | 12.06 | 268 | 68008 | 509793 | 70350375 |
Drug-induced liver injury | 60.39 | 12.06 | 153 | 68123 | 55960 | 70804208 |
Osteochondrosis | 60.22 | 12.06 | 30 | 68246 | 1593 | 70858575 |
Hepatorenal failure | 59.10 | 12.06 | 27 | 68249 | 1180 | 70858988 |
Systemic lupus erythematosus | 58.87 | 12.06 | 13 | 68263 | 101889 | 70758279 |
Electrocardiogram abnormal | 57.83 | 12.06 | 71 | 68205 | 14593 | 70845575 |
Apathy | 57.55 | 12.06 | 64 | 68212 | 11844 | 70848324 |
Dizziness | 57.55 | 12.06 | 691 | 67585 | 463450 | 70396718 |
Suspected product quality issue | 56.97 | 12.06 | 18 | 68258 | 277 | 70859891 |
Lethargy | 56.89 | 12.06 | 4 | 68272 | 75246 | 70784922 |
Psoriasis | 55.98 | 12.06 | 13 | 68263 | 98420 | 70761748 |
Appendicitis | 54.97 | 12.06 | 74 | 68202 | 16659 | 70843509 |
Hyponatraemia | 54.78 | 12.06 | 301 | 67975 | 159786 | 70700382 |
Dysuria | 54.73 | 12.06 | 130 | 68146 | 45664 | 70814504 |
Nasopharyngitis | 54.37 | 12.06 | 81 | 68195 | 222125 | 70638043 |
Mucosal haemorrhage | 54.31 | 12.06 | 32 | 68244 | 2377 | 70857791 |
Drug hypersensitivity | 53.87 | 12.06 | 107 | 68169 | 262352 | 70597816 |
Pericarditis | 52.74 | 12.06 | 9 | 68267 | 84696 | 70775472 |
Abdominal distension | 51.89 | 12.06 | 219 | 68057 | 104450 | 70755718 |
Dyschezia | 51.75 | 12.06 | 32 | 68244 | 2595 | 70857573 |
Upper gastrointestinal haemorrhage | 51.00 | 12.06 | 112 | 68164 | 37365 | 70822803 |
Myocardial infarction | 50.93 | 12.06 | 54 | 68222 | 171591 | 70688577 |
Feeling abnormal | 50.34 | 12.06 | 38 | 68238 | 142281 | 70717887 |
Interstitial lung disease | 50.12 | 12.06 | 19 | 68257 | 104666 | 70755502 |
Acute hepatic failure | 49.95 | 12.06 | 93 | 68183 | 27579 | 70832589 |
Drug reaction with eosinophilia and systemic symptoms | 49.26 | 12.06 | 145 | 68131 | 57868 | 70802300 |
Mental status changes | 48.74 | 12.06 | 3 | 68273 | 63098 | 70797070 |
Arthralgia | 48.59 | 12.06 | 285 | 67991 | 503105 | 70357063 |
Toxicity to various agents | 48.06 | 12.06 | 197 | 68079 | 381975 | 70478193 |
Alopecia | 47.93 | 12.06 | 73 | 68203 | 198417 | 70661751 |
Micturition disorder | 46.48 | 12.06 | 34 | 68242 | 3641 | 70856527 |
Suspected product contamination | 46.12 | 12.06 | 12 | 68264 | 87 | 70860081 |
Syncope | 45.41 | 12.06 | 294 | 67982 | 165415 | 70694753 |
Tumour pain | 45.03 | 12.06 | 27 | 68249 | 2071 | 70858097 |
Nasal disorder | 44.98 | 12.06 | 32 | 68244 | 3282 | 70856886 |
Maternal exposure during pregnancy | 44.51 | 12.06 | 28 | 68248 | 115317 | 70744851 |
Negative pressure pulmonary oedema | 44.46 | 12.06 | 14 | 68262 | 213 | 70859955 |
Therapy non-responder | 44.05 | 12.06 | 10 | 68266 | 76905 | 70783263 |
Subileus | 43.87 | 12.06 | 38 | 68238 | 5189 | 70854979 |
Neuropathy peripheral | 43.46 | 12.06 | 35 | 68241 | 126861 | 70733307 |
Thrombocytopenia | 43.40 | 12.06 | 385 | 67891 | 238725 | 70621443 |
Hypokalaemia | 43.09 | 12.06 | 244 | 68032 | 130944 | 70729224 |
Product use issue | 42.65 | 12.06 | 67 | 68209 | 179870 | 70680298 |
Thirst | 42.46 | 12.06 | 61 | 68215 | 14588 | 70845580 |
Immobile | 42.37 | 12.06 | 41 | 68235 | 6453 | 70853715 |
Haemorrhagic erosive gastritis | 42.21 | 12.06 | 17 | 68259 | 543 | 70859625 |
Stevens-Johnson syndrome | 41.90 | 12.06 | 101 | 68175 | 35806 | 70824362 |
Pancytopenia | 40.13 | 12.06 | 266 | 68010 | 150841 | 70709327 |
Gastritis erosive | 40.01 | 12.06 | 49 | 68227 | 10046 | 70850122 |
Product used for unknown indication | 39.99 | 12.06 | 23 | 68253 | 1633 | 70858535 |
Spinal pain | 39.41 | 12.06 | 57 | 68219 | 13713 | 70846455 |
Helicobacter infection | 39.21 | 12.06 | 4 | 68272 | 55652 | 70804516 |
Nasal congestion | 38.70 | 12.06 | 8 | 68268 | 65664 | 70794504 |
Disease progression | 38.42 | 12.06 | 57 | 68219 | 156615 | 70703553 |
Hospitalisation | 37.86 | 12.06 | 16 | 68260 | 82552 | 70777616 |
Type I hypersensitivity | 37.27 | 12.06 | 30 | 68246 | 3702 | 70856466 |
Cellulitis | 36.83 | 12.06 | 25 | 68251 | 98903 | 70761265 |
Arrhythmia | 36.45 | 12.06 | 128 | 68148 | 56015 | 70804153 |
Chills | 35.54 | 12.06 | 250 | 68026 | 144536 | 70715632 |
Respiratory arrest | 35.23 | 12.06 | 5 | 68271 | 53928 | 70806240 |
Platelet count decreased | 34.57 | 12.06 | 75 | 68201 | 178147 | 70682021 |
Listless | 34.23 | 12.06 | 28 | 68248 | 3535 | 70856633 |
Therapeutic product effect incomplete | 34.13 | 12.06 | 39 | 68237 | 119843 | 70740325 |
Hypoaesthesia | 33.88 | 12.06 | 60 | 68216 | 153679 | 70706489 |
Heart rate decreased | 33.69 | 12.06 | 9 | 68267 | 62006 | 70798162 |
Urogenital haemorrhage | 33.43 | 12.06 | 16 | 68260 | 778 | 70859390 |
Febrile infection | 33.21 | 12.06 | 26 | 68250 | 3083 | 70857085 |
Multiple organ dysfunction syndrome | 33.14 | 12.06 | 198 | 68078 | 108317 | 70751851 |
Heart rate increased | 33.06 | 12.06 | 32 | 68244 | 106116 | 70754052 |
Haematuria | 33.05 | 12.06 | 135 | 68141 | 63438 | 70796730 |
Depressed level of consciousness | 33.04 | 12.06 | 169 | 68107 | 87262 | 70772906 |
Drug interaction | 33.02 | 12.06 | 533 | 67743 | 380908 | 70479260 |
Bradycardia | 32.86 | 12.06 | 219 | 68057 | 124396 | 70735772 |
Blood pressure measurement | 32.67 | 12.06 | 13 | 68263 | 402 | 70859766 |
Gastrointestinal disorder | 32.59 | 12.06 | 32 | 68244 | 105395 | 70754773 |
Faecaloma | 32.48 | 12.06 | 45 | 68231 | 10406 | 70849762 |
Psoriatic arthropathy | 32.29 | 12.06 | 11 | 68265 | 64760 | 70795408 |
Urogenital infection bacterial | 31.85 | 12.06 | 9 | 68267 | 92 | 70860076 |
Discomfort | 31.45 | 12.06 | 33 | 68243 | 105403 | 70754765 |
Rash | 31.44 | 12.06 | 327 | 67949 | 510235 | 70349933 |
Hypersensitivity | 31.07 | 12.06 | 115 | 68161 | 229697 | 70630471 |
Weight increased | 31 | 12.06 | 124 | 68152 | 242207 | 70617961 |
Loss of personal independence in daily activities | 30.89 | 12.06 | 22 | 68254 | 84888 | 70775280 |
Injection site swelling | 30.67 | 12.06 | 3 | 68273 | 43154 | 70817014 |
Flank pain | 30.56 | 12.06 | 58 | 68218 | 17444 | 70842724 |
Hepatitis acute | 30.46 | 12.06 | 51 | 68225 | 13911 | 70846257 |
Irritable bowel syndrome | 30.37 | 12.06 | 6 | 68270 | 50844 | 70809324 |
Pain in jaw | 30.23 | 12.06 | 3 | 68273 | 42666 | 70817502 |
Drug abuse | 30.22 | 12.06 | 60 | 68216 | 147196 | 70712972 |
Folliculitis | 30.15 | 12.06 | 3 | 68273 | 42567 | 70817601 |
Off label use | 30.08 | 12.06 | 519 | 67757 | 742541 | 70117627 |
Platelet dysfunction | 29.72 | 12.06 | 12 | 68264 | 386 | 70859782 |
Chronic fatigue syndrome | 29.58 | 12.06 | 17 | 68259 | 1205 | 70858963 |
Disorientation | 29.32 | 12.06 | 122 | 68154 | 57801 | 70802367 |
Unresponsive to stimuli | 29.24 | 12.06 | 7 | 68269 | 51924 | 70808244 |
Injection site erythema | 29.11 | 12.06 | 17 | 68259 | 72907 | 70787261 |
Coronavirus test positive | 28.85 | 12.06 | 16 | 68260 | 1059 | 70859109 |
Urosepsis | 28.62 | 12.06 | 68 | 68208 | 23881 | 70836287 |
Pelvic fracture | 28.49 | 12.06 | 44 | 68232 | 11217 | 70848951 |
Adverse drug reaction | 28.49 | 12.06 | 8 | 68268 | 53336 | 70806832 |
Contusion | 28.18 | 12.06 | 50 | 68226 | 127986 | 70732182 |
Reduced facial expression | 28.04 | 12.06 | 21 | 68255 | 2331 | 70857837 |
Peripheral swelling | 27.82 | 12.06 | 125 | 68151 | 236438 | 70623730 |
C-reactive protein increased | 27.80 | 12.06 | 192 | 68084 | 110325 | 70749843 |
Angina pectoris | 27.77 | 12.06 | 106 | 68170 | 48277 | 70811891 |
Neuromuscular block prolonged | 27.40 | 12.06 | 15 | 68261 | 968 | 70859200 |
Cardio-respiratory arrest | 27.33 | 12.06 | 34 | 68242 | 100643 | 70759525 |
Therapeutic response decreased | 27.33 | 12.06 | 11 | 68265 | 58442 | 70801726 |
Blood phosphorus increased | 27.05 | 12.06 | 33 | 68243 | 6737 | 70853431 |
Respiratory tract haemorrhage | 26.88 | 12.06 | 18 | 68258 | 1674 | 70858494 |
Fluid intake reduced | 26.86 | 12.06 | 30 | 68246 | 5577 | 70854591 |
Accessory spleen | 26.48 | 12.06 | 9 | 68267 | 176 | 70859992 |
Blood pressure fluctuation | 26.16 | 12.06 | 12 | 68264 | 59000 | 70801168 |
Facial nerve disorder | 25.98 | 12.06 | 13 | 68263 | 697 | 70859471 |
Fibromyalgia | 25.90 | 12.06 | 7 | 68269 | 47867 | 70812301 |
Flatulence | 25.61 | 12.06 | 88 | 68188 | 38093 | 70822075 |
Bicytopenia | 25.47 | 12.06 | 25 | 68251 | 4003 | 70856165 |
Angioedema | 25.33 | 12.06 | 129 | 68147 | 66481 | 70793687 |
Hepatic cyst | 25.31 | 12.06 | 29 | 68247 | 5542 | 70854626 |
Delirium | 25.30 | 12.06 | 140 | 68136 | 74474 | 70785694 |
Cardiac arrest | 25.01 | 12.06 | 75 | 68201 | 159759 | 70700409 |
Gastritis haemorrhagic | 24.94 | 12.06 | 20 | 68256 | 2454 | 70857714 |
Vertigo | 24.30 | 12.06 | 122 | 68154 | 62521 | 70797647 |
Ventricular fibrillation | 24.20 | 12.06 | 69 | 68207 | 27042 | 70833126 |
Flushing | 24.19 | 12.06 | 26 | 68250 | 82146 | 70778022 |
Decreased appetite | 24.19 | 12.06 | 420 | 67856 | 304360 | 70555808 |
Unevaluable event | 24.01 | 12.06 | 10 | 68266 | 52053 | 70808115 |
Nail toxicity | 23.97 | 12.06 | 10 | 68266 | 350 | 70859818 |
Injection site reaction | 23.94 | 12.06 | 9 | 68267 | 49843 | 70810325 |
Drug resistance | 23.90 | 12.06 | 4 | 68272 | 38186 | 70821982 |
Orthostatic hypotension | 23.76 | 12.06 | 10 | 68266 | 51733 | 70808435 |
Cardiac disorder | 23.50 | 12.06 | 14 | 68262 | 59401 | 70800767 |
Psychotic disorder | 23.48 | 12.06 | 4 | 68272 | 37697 | 70822471 |
Hydrocholecystis | 23.45 | 12.06 | 10 | 68266 | 370 | 70859798 |
Long QT syndrome | 22.98 | 12.06 | 27 | 68249 | 5300 | 70854868 |
Ileus | 22.92 | 12.06 | 63 | 68213 | 24174 | 70835994 |
Depression | 22.88 | 12.06 | 106 | 68170 | 198868 | 70661300 |
Type 2 diabetes mellitus | 22.83 | 12.06 | 7 | 68269 | 44073 | 70816095 |
Wound | 22.78 | 12.06 | 168 | 68108 | 98564 | 70761604 |
Inappropriate schedule of product administration | 22.78 | 12.06 | 43 | 68233 | 107512 | 70752656 |
Blood pressure decreased | 22.71 | 12.06 | 33 | 68243 | 91482 | 70768686 |
Post-traumatic pain | 22.70 | 12.06 | 10 | 68266 | 401 | 70859767 |
Cerebrovascular accident | 22.68 | 12.06 | 67 | 68209 | 143403 | 70716765 |
Gallbladder polyp | 22.64 | 12.06 | 13 | 68263 | 920 | 70859248 |
Thirst decreased | 22.63 | 12.06 | 9 | 68267 | 278 | 70859890 |
White blood cell count decreased | 22.42 | 12.06 | 86 | 68190 | 170055 | 70690113 |
Exposure during pregnancy | 22.40 | 12.06 | 31 | 68245 | 87686 | 70772482 |
Migraine | 22.24 | 12.06 | 22 | 68254 | 72216 | 70787952 |
Hepatitis cholestatic | 22.19 | 12.06 | 42 | 68234 | 12608 | 70847560 |
Acute generalised exanthematous pustulosis | 22.07 | 12.06 | 47 | 68229 | 15350 | 70844818 |
Sepsis | 21.99 | 12.06 | 344 | 67932 | 244201 | 70615967 |
Gastritis | 21.85 | 12.06 | 93 | 68183 | 44498 | 70815670 |
Pulmonary sepsis | 21.80 | 12.06 | 21 | 68255 | 3286 | 70856882 |
Dysdiadochokinesis | 21.71 | 12.06 | 9 | 68267 | 310 | 70859858 |
Oliguria | 21.64 | 12.06 | 46 | 68230 | 15005 | 70845163 |
Disease recurrence | 21.31 | 12.06 | 5 | 68271 | 37598 | 70822570 |
Muscle tone disorder | 21.19 | 12.06 | 7 | 68269 | 125 | 70860043 |
Hyperventilation | 20.94 | 12.06 | 30 | 68246 | 7156 | 70853012 |
Blood folate increased | 20.78 | 12.06 | 10 | 68266 | 492 | 70859676 |
Coombs negative haemolytic anaemia | 20.76 | 12.06 | 9 | 68267 | 347 | 70859821 |
Hepatic function abnormal | 20.60 | 12.06 | 21 | 68255 | 67975 | 70792193 |
Tension headache | 20.50 | 12.06 | 21 | 68255 | 3540 | 70856628 |
Full blood count abnormal | 20.22 | 12.06 | 4 | 68272 | 33874 | 70826294 |
Hypertensive crisis | 20.17 | 12.06 | 52 | 68224 | 19210 | 70840958 |
Cardiac failure | 20.09 | 12.06 | 219 | 68057 | 143322 | 70716846 |
Hypoxia | 20.05 | 12.06 | 37 | 68239 | 93307 | 70766861 |
Duodenal ulcer | 20.04 | 12.06 | 45 | 68231 | 15235 | 70844933 |
Transaminases increased | 19.98 | 12.06 | 94 | 68182 | 46924 | 70813244 |
Haemorrhagic necrotic pancreatitis | 19.96 | 12.06 | 7 | 68269 | 151 | 70860017 |
Prescription drug used without a prescription | 19.70 | 12.06 | 19 | 68257 | 2978 | 70857190 |
Pseudarthrosis | 19.37 | 12.06 | 8 | 68268 | 273 | 70859895 |
Vascular encephalopathy | 19.37 | 12.06 | 10 | 68266 | 573 | 70859595 |
Hepatitis toxic | 19.33 | 12.06 | 23 | 68253 | 4576 | 70855592 |
Atrial fibrillation | 19.18 | 12.06 | 266 | 68010 | 184082 | 70676086 |
Adverse event | 19.08 | 12.06 | 12 | 68264 | 49449 | 70810719 |
Hyperglycaemia | 18.47 | 12.06 | 116 | 68160 | 64556 | 70795612 |
Head injury | 18.46 | 12.06 | 5 | 68271 | 34136 | 70826032 |
Anxiety | 18.02 | 12.06 | 131 | 68145 | 220199 | 70639969 |
Cardiogenic shock | 18.00 | 12.06 | 76 | 68200 | 36231 | 70823937 |
Pneumobilia | 17.76 | 12.06 | 7 | 68269 | 211 | 70859957 |
Internal fixation of fracture | 17.74 | 12.06 | 8 | 68268 | 339 | 70859829 |
Gastric ulcer perforation | 17.68 | 12.06 | 15 | 68261 | 1992 | 70858176 |
Ill-defined disorder | 17.63 | 12.06 | 16 | 68260 | 54725 | 70805443 |
Gastrointestinal sounds abnormal | 17.57 | 12.06 | 23 | 68253 | 5038 | 70855130 |
Spontaneous haemorrhage | 17.52 | 12.06 | 9 | 68267 | 510 | 70859658 |
Implant site inflammation | 17.43 | 12.06 | 7 | 68269 | 222 | 70859946 |
Product packaging confusion | 17.37 | 12.06 | 7 | 68269 | 224 | 70859944 |
Lack of application site rotation | 17.17 | 12.06 | 4 | 68272 | 17 | 70860151 |
Oropharyngeal discomfort | 17.16 | 12.06 | 25 | 68251 | 6054 | 70854114 |
Amnesia | 17.09 | 12.06 | 15 | 68261 | 52140 | 70808028 |
Anaemia of malignant disease | 17.09 | 12.06 | 10 | 68266 | 733 | 70859435 |
Pulmonary hypertension | 17.00 | 12.06 | 12 | 68264 | 46524 | 70813644 |
Tonsillitis | 16.97 | 12.06 | 25 | 68251 | 6115 | 70854053 |
Intentional product use issue | 16.96 | 12.06 | 59 | 68217 | 120083 | 70740085 |
Localised infection | 16.90 | 12.06 | 70 | 68206 | 33088 | 70827080 |
Medication overuse headache | 16.90 | 12.06 | 10 | 68266 | 749 | 70859419 |
Acute kidney injury | 16.86 | 12.06 | 586 | 67690 | 474038 | 70386130 |
Hyperaemia | 16.75 | 12.06 | 17 | 68259 | 2834 | 70857334 |
Somnolence | 16.69 | 12.06 | 296 | 67980 | 215310 | 70644858 |
Paraparesis | 16.67 | 12.06 | 19 | 68257 | 3610 | 70856558 |
Lividity | 16.56 | 12.06 | 8 | 68268 | 397 | 70859771 |
Bulimia nervosa | 16.47 | 12.06 | 7 | 68269 | 257 | 70859911 |
International normalised ratio increased | 16.46 | 12.06 | 33 | 68243 | 80693 | 70779475 |
Seizure | 16.46 | 12.06 | 102 | 68174 | 177860 | 70682308 |
Weight bearing difficulty | 16.45 | 12.06 | 17 | 68259 | 2895 | 70857273 |
Spinal cord injury cauda equina | 16.43 | 12.06 | 6 | 68270 | 146 | 70860022 |
Rash pruritic | 16.34 | 12.06 | 22 | 68254 | 62969 | 70797199 |
Concomitant disease aggravated | 16.25 | 12.06 | 36 | 68240 | 12078 | 70848090 |
Hypervolaemia | 16.21 | 12.06 | 9 | 68267 | 39697 | 70820471 |
Autoimmune nephritis | 16.11 | 12.06 | 9 | 68267 | 604 | 70859564 |
Antineutrophil cytoplasmic antibody positive | 15.94 | 12.06 | 11 | 68265 | 1075 | 70859093 |
Joint stiffness | 15.83 | 12.06 | 7 | 68269 | 35169 | 70824999 |
Breath sounds normal | 15.76 | 12.06 | 3 | 68273 | 3 | 70860165 |
Drain site complication | 15.76 | 12.06 | 3 | 68273 | 3 | 70860165 |
Lower gastrointestinal haemorrhage | 15.69 | 12.06 | 40 | 68236 | 14680 | 70845488 |
Fluid retention | 15.59 | 12.06 | 23 | 68253 | 63362 | 70796806 |
Peritoneal perforation | 15.57 | 12.06 | 6 | 68270 | 170 | 70859998 |
Vitamin B6 deficiency | 15.41 | 12.06 | 7 | 68269 | 302 | 70859866 |
Arthritis | 15.31 | 12.06 | 46 | 68230 | 97934 | 70762234 |
Visual acuity reduced | 15.27 | 12.06 | 4 | 68272 | 27926 | 70832242 |
Product impurity | 15.20 | 12.06 | 5 | 68271 | 88 | 70860080 |
Knee arthroplasty | 15.17 | 12.06 | 7 | 68269 | 34294 | 70825874 |
Somatosensory evoked potentials abnormal | 15.16 | 12.06 | 6 | 68270 | 183 | 70859985 |
Prescribed underdose | 14.96 | 12.06 | 50 | 68226 | 21335 | 70838833 |
Respiratory alkalosis | 14.95 | 12.06 | 19 | 68257 | 4042 | 70856126 |
Throat tightness | 14.84 | 12.06 | 3 | 68273 | 25019 | 70835149 |
Lordosis | 14.69 | 12.06 | 7 | 68269 | 337 | 70859831 |
Therapy interrupted | 14.66 | 12.06 | 3 | 68273 | 24799 | 70835369 |
Peritoneal adhesions | 14.61 | 12.06 | 7 | 68269 | 341 | 70859827 |
Preternatural anus | 14.61 | 12.06 | 5 | 68271 | 100 | 70860068 |
Necrotising fasciitis | 14.56 | 12.06 | 22 | 68254 | 5504 | 70854664 |
Head discomfort | 14.52 | 12.06 | 36 | 68240 | 12987 | 70847181 |
Skin haemorrhage | 14.51 | 12.06 | 31 | 68245 | 10149 | 70850019 |
Blood uric acid increased | 14.42 | 12.06 | 29 | 68247 | 9100 | 70851068 |
Subacute hepatic failure | 14.41 | 12.06 | 6 | 68270 | 209 | 70859959 |
Circulatory collapse | 14.40 | 12.06 | 70 | 68206 | 35404 | 70824764 |
Colitis | 14.39 | 12.06 | 108 | 68168 | 63706 | 70796462 |
Cardiac murmur functional | 14.33 | 12.06 | 4 | 68272 | 39 | 70860129 |
Hyperkinesia | 14.25 | 12.06 | 15 | 68261 | 2608 | 70857560 |
Oedematous pancreatitis | 14.25 | 12.06 | 10 | 68266 | 1003 | 70859165 |
Rhabdomyolysis | 14.22 | 12.06 | 46 | 68230 | 95714 | 70764454 |
Condition aggravated | 14.20 | 12.06 | 524 | 67752 | 427111 | 70433057 |
Wrong technique in product usage process | 14.08 | 12.06 | 28 | 68248 | 68670 | 70791498 |
Foreign body | 14.04 | 12.06 | 15 | 68261 | 2653 | 70857515 |
C-reactive protein abnormal | 14.02 | 12.06 | 10 | 68266 | 38569 | 70821599 |
Mycobacterium fortuitum infection | 14.02 | 12.06 | 6 | 68270 | 224 | 70859944 |
Influenza | 14.01 | 12.06 | 59 | 68217 | 113641 | 70746527 |
Cross sensitivity reaction | 13.97 | 12.06 | 17 | 68259 | 3461 | 70856707 |
Vasculitis | 13.93 | 12.06 | 46 | 68230 | 19512 | 70840656 |
Solar dermatitis | 13.87 | 12.06 | 6 | 68270 | 230 | 70859938 |
Hepatic failure | 13.83 | 12.06 | 99 | 68177 | 57526 | 70802642 |
Peripheral circulatory failure | 13.82 | 12.06 | 10 | 68266 | 1053 | 70859115 |
Abdominal wall cyst | 13.81 | 12.06 | 4 | 68272 | 45 | 70860123 |
Pregnancy | 13.80 | 12.06 | 3 | 68273 | 23778 | 70836390 |
Urine uric acid decreased | 13.76 | 12.06 | 5 | 68271 | 120 | 70860048 |
Wrong product administered | 13.75 | 12.06 | 27 | 68249 | 8324 | 70851844 |
Tracheal pain | 13.73 | 12.06 | 4 | 68272 | 46 | 70860122 |
Necrolytic migratory erythema | 13.69 | 12.06 | 3 | 68273 | 9 | 70860159 |
Rhinorrhoea | 13.64 | 12.06 | 27 | 68249 | 66344 | 70793824 |
Acute respiratory distress syndrome | 13.36 | 12.06 | 12 | 68264 | 41242 | 70818926 |
Stenosis | 13.32 | 12.06 | 13 | 68263 | 2068 | 70858100 |
Pulmonary vein occlusion | 13.31 | 12.06 | 5 | 68271 | 132 | 70860036 |
Diarrhoea | 13.27 | 12.06 | 899 | 67377 | 782442 | 70077726 |
Lumbar vertebral fracture | 13.24 | 12.06 | 22 | 68254 | 5965 | 70854203 |
Genitourinary tract infection | 13.16 | 12.06 | 6 | 68270 | 261 | 70859907 |
Insomnia | 13.16 | 12.06 | 140 | 68136 | 217666 | 70642502 |
Leukocytosis | 13.16 | 12.06 | 74 | 68202 | 39594 | 70820574 |
Intestinal haemorrhage | 13.15 | 12.06 | 22 | 68254 | 5998 | 70854170 |
Toxic neuropathy | 13.14 | 12.06 | 9 | 68267 | 869 | 70859299 |
Tumour haemorrhage | 13.05 | 12.06 | 17 | 68259 | 3705 | 70856463 |
Coma | 13.03 | 12.06 | 45 | 68231 | 91799 | 70768369 |
Urinary sediment abnormal | 13.03 | 12.06 | 5 | 68271 | 140 | 70860028 |
Leptotrichia infection | 13.01 | 12.06 | 4 | 68272 | 56 | 70860112 |
Lung disorder | 12.84 | 12.06 | 30 | 68246 | 69454 | 70790714 |
Hyperresponsive to stimuli | 12.82 | 12.06 | 4 | 68272 | 59 | 70860109 |
Sensory level abnormal | 12.80 | 12.06 | 5 | 68271 | 147 | 70860021 |
Skin irritation | 12.79 | 12.06 | 29 | 68247 | 9880 | 70850288 |
Drug ineffective for unapproved indication | 12.73 | 12.06 | 11 | 68265 | 38527 | 70821641 |
Petechiae | 12.69 | 12.06 | 44 | 68232 | 19128 | 70841040 |
Organic brain syndrome | 12.68 | 12.06 | 7 | 68269 | 459 | 70859709 |
Confusional state | 12.65 | 12.06 | 195 | 68081 | 284203 | 70575965 |
Anal haemorrhage | 12.65 | 12.06 | 17 | 68259 | 3819 | 70856349 |
Viral infection | 12.63 | 12.06 | 11 | 68265 | 38380 | 70821788 |
Reactive gastropathy | 12.60 | 12.06 | 7 | 68269 | 465 | 70859703 |
Alpha 2 globulin increased | 12.56 | 12.06 | 5 | 68271 | 155 | 70860013 |
Polyneuropathy in malignant disease | 12.56 | 12.06 | 5 | 68271 | 155 | 70860013 |
Dyspnoea exertional | 12.55 | 12.06 | 123 | 68153 | 78307 | 70781861 |
Vision blurred | 12.52 | 12.06 | 48 | 68228 | 94936 | 70765232 |
Rash erythematous | 12.49 | 12.06 | 19 | 68257 | 51699 | 70808469 |
Anaemia folate deficiency | 12.42 | 12.06 | 6 | 68270 | 298 | 70859870 |
Pure white cell aplasia | 12.40 | 12.06 | 4 | 68272 | 66 | 70860102 |
Cytomegalovirus infection | 12.36 | 12.06 | 12 | 68264 | 39746 | 70820422 |
Product prescribing issue | 12.35 | 12.06 | 15 | 68261 | 3049 | 70857119 |
Adrenocortical insufficiency acute | 12.32 | 12.06 | 14 | 68262 | 2652 | 70857516 |
Food interaction | 12.21 | 12.06 | 11 | 68265 | 1582 | 70858586 |
No adverse event | 12.13 | 12.06 | 8 | 68268 | 32145 | 70828023 |
Brain contusion | 12.08 | 12.06 | 10 | 68266 | 1284 | 70858884 |
Obstructive airways disorder | 12.07 | 12.06 | 5 | 68271 | 26108 | 70834060 |
Laryngeal oedema | 12.06 | 12.06 | 24 | 68252 | 7471 | 70852697 |
None
Source | Code | Description |
---|---|---|
ATC | N02BB02 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones |
ATC | N02BB52 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones |
ATC | N02BB72 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D058633 | Antipyretics |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35493 | anti-pyretic |
CHEBI has role | CHEBI:35842 | anti-rheumatic drugs |
CHEBI has role | CHEBI:49110 | peripheral nervous system drugs |
CHEBI has role | CHEBI:50266 | Prodrugs |
CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
CHEBI has role | CHEBI:73263 | cyclooxygenase-3 inhibitors |
None
None
Product | Applicant | Ingredients |
---|---|---|
Zimeta | Kindred Biosciences Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 0.21 | acidic |
pKa2 | 5.06 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily A member 1 | Ion channel | BLOCKER | IC50 | 4.04 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
ID | Source |
---|---|
D08190 | KEGG_DRUG |
N0000167060 | NUI |
50567-35-6 | SECONDARY_CAS_RN |
CHEBI:59033 | CHEBI |
CHEMBL3989803 | ChEMBL_ID |
C024864 | MESH_SUPPLEMENTAL_RECORD_UI |
10608 | IUPHAR_LIGAND_ID |
5907-38-0 | SECONDARY_CAS_RN |
DB04817 | DRUGBANK_ID |
934T64RMNJ | UNII |
1537943 | RXNORM |
NOCODE | MMSL |
001609 | NDDF |
006029 | NDDF |
22165008 | SNOMEDCT_US |
735071007 | SNOMEDCT_US |
780831000 | SNOMEDCT_US |
781025005 | SNOMEDCT_US |
C0012586 | UMLSCUI |
D004177 | MESH_DESCRIPTOR_UI |
CHEMBL461522 | ChEMBL_ID |
477 | INN_ID |
3111 | PUBCHEM_CID |
6150-97-6 | SECONDARY_CAS_RN |
51996-59-9 | SECONDARY_CAS_RN |
None