metamizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory analgesics, phenylbutazone derivatives 4659 68-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • algocalmin
  • metamizole
  • metamizole sodium
  • metamizol
  • metapyrin
  • methampyrone
  • dipyrone
  • dipyrone monohydrate
  • sulpyrine
  • metamizole magnesium
  • metamizole calcium
A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
  • Molecular weight: 311.36
  • Formula: C13H17N3O4S
  • CLOGP: -1.20
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 81.16
  • ALOGS: -2.09
  • ROTB: 4

Drug dosage:

DoseUnitRoute
3 g O
3 g P
3 g R

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1349.59 12.44 1078 41667 168932 56080390
Product prescribing error 569.20 12.44 300 42445 22886 56226436
Haematochezia 317.22 12.44 264 42481 43454 56205868
Agranulocytosis 283.89 12.44 190 42555 22469 56226853
Anaemia 274.77 12.44 618 42127 266893 55982429
Product monitoring error 273.99 12.44 102 42643 3357 56245965
Systemic infection 246.56 12.44 93 42652 3176 56246146
Drug ineffective 220.81 12.44 225 42520 918764 55330558
Fracture 192.50 12.44 137 42608 17881 56231441
Haematemesis 149.63 12.44 144 42601 28614 56220708
Polyneuropathy 148.16 12.44 103 42642 12947 56236375
Rheumatoid arthritis 141.34 12.44 57 42688 382547 55866775
Joint swelling 141.13 12.44 25 42720 289775 55959547
Fall 136.77 12.44 585 42160 356925 55892397
Aspirin-exacerbated respiratory disease 131.81 12.44 42 42703 855 56248467
Labelled drug-drug interaction medication error 125.83 12.44 89 42656 11497 56237825
Product dose omission issue 112.98 12.44 12 42733 204741 56044581
Systemic lupus erythematosus 112.18 12.44 6 42739 180072 56069250
Abdominal discomfort 111.32 12.44 36 42709 277238 55972084
Leukopenia 111.26 12.44 196 42549 70744 56178578
Infusion related reaction 106.18 12.44 16 42729 208915 56040407
Synovitis 104.96 12.44 4 42741 161301 56088021
Abdominal pain lower 104.15 12.44 107 42638 22985 56226337
Pemphigus 101.95 12.44 4 42741 157208 56092114
Treatment failure 99.29 12.44 8 42737 170384 56078938
Pallor 96.65 12.44 105 42640 24044 56225278
Restlessness 90.06 12.44 106 42639 26480 56222842
Therapeutic product effect decreased 88.36 12.44 12 42733 169440 56079882
Toxic epidermal necrolysis 86.75 12.44 95 42650 21947 56227375
Dyspnoea 84.73 12.44 751 41994 591826 55657496
Erysipelas 84.38 12.44 58 42687 7155 56242167
Arthropathy 83.96 12.44 24 42721 200251 56049071
Apathy 83.83 12.44 60 42685 7894 56241428
Abdominal pain 83.44 12.44 403 42342 258402 55990920
Swelling 83.22 12.44 39 42706 239732 56009590
Drug intolerance 83.18 12.44 49 42696 264769 55984553
Vomiting 81.54 12.44 651 42094 497577 55751745
Product administration error 80.28 12.44 89 42656 20840 56228482
Stevens-Johnson syndrome 77.83 12.44 91 42654 22572 56226750
Sinusitis 76.90 12.44 27 42718 197554 56051768
Arrhythmia 75.57 12.44 112 42633 34971 56214351
Nausea 74.28 12.44 895 41850 763283 55486039
Alopecia 70.90 12.44 71 42674 293387 55955935
Abdominal pain upper 70.43 12.44 295 42450 178018 56071304
Tachypnoea 65.10 12.44 69 42676 15361 56233961
Pancytopenia 64.42 12.44 180 42565 88535 56160787
Malaise 64.39 12.44 113 42632 367747 55881575
Drug-induced liver injury 64.37 12.44 103 42642 34359 56214963
Drug hypersensitivity 63.75 12.44 69 42676 275136 55974186
Jaundice 61.48 12.44 89 42656 27205 56222117
Pericarditis 61.04 12.44 6 42739 108917 56140405
Renal impairment 60.82 12.44 166 42579 80547 56168775
Electrolyte imbalance 59.58 12.44 71 42674 17962 56231360
Haematoma 58.84 12.44 95 42650 31924 56217398
Lower respiratory tract infection 57.80 12.44 9 42736 114785 56134537
Upper gastrointestinal haemorrhage 57.76 12.44 68 42677 16986 56232336
Product use issue 56.18 12.44 36 42709 186005 56063317
Acute hepatic failure 55.98 12.44 66 42679 16512 56232810
Maternal exposure during pregnancy 55.46 12.44 38 42707 189515 56059807
Completed suicide 54.31 12.44 17 42728 133816 56115506
Cardiac failure 54.22 12.44 161 42584 81932 56167390
Musculoskeletal stiffness 53.13 12.44 26 42719 155981 56093341
Gamma-glutamyltransferase increased 52.95 12.44 89 42656 30916 56218406
Ascites 52.81 12.44 99 42646 37445 56211877
Tachycardia 52.23 12.44 188 42557 105688 56143634
Drug interaction 50.73 12.44 302 42443 209453 56039869
Oedema peripheral 50.38 12.44 260 42485 170994 56078328
Haemorrhagic erosive gastritis 47.23 12.44 15 42730 302 56249020
Dysuria 46.97 12.44 84 42661 30645 56218677
Osteochondrosis 46.56 12.44 21 42724 1135 56248187
Contraindicated product administered 46.18 12.44 44 42701 186242 56063080
Therapeutic drug monitoring analysis not performed 46.09 12.44 20 42725 985 56248337
Hypokalaemia 45.99 12.44 167 42578 94270 56155052
Malignant neoplasm progression 45.47 12.44 141 42604 73446 56175876
Gastritis erosive 45.29 12.44 36 42709 5541 56243781
Disturbance in attention 44.77 12.44 85 42660 32455 56216867
Pyrexia 44.67 12.44 500 42245 418273 55831049
Atrial fibrillation 43.60 12.44 181 42564 108716 56140606
Arthralgia 43.28 12.44 215 42530 501454 55747868
Nasopharyngitis 43.20 12.44 63 42682 220896 56028426
Dehydration 43.19 12.44 236 42509 158589 56090733
Nasal disorder 43.17 12.44 26 42719 2556 56246766
Listless 42.71 12.44 26 42719 2606 56246716
Syncope 41.88 12.44 178 42567 108021 56141301
Concomitant disease aggravated 41.57 12.44 41 42704 8385 56240937
Tumour pain 41.30 12.44 20 42725 1271 56248051
Helicobacter infection 41.14 12.44 4 42741 73264 56176058
Hepatorenal failure 40.71 12.44 16 42729 611 56248711
Discomfort 40.68 12.44 29 42716 141732 56107590
Stenosis 40.67 12.44 20 42725 1314 56248008
Reduced facial expression 40.55 12.44 22 42723 1774 56247548
Acute kidney injury 39.96 12.44 316 42429 240447 56008875
Injection site pain 39.15 12.44 20 42725 117098 56132224
Medication error 39.05 12.44 94 42651 42241 56207081
Psoriasis 39.01 12.44 11 42734 92681 56156641
Weight increased 38.84 12.44 72 42673 229631 56019691
Cardiac failure congestive 37.68 12.44 10 42735 87710 56161612
Subileus 37.60 12.44 25 42720 2919 56246403
Product used for unknown indication 37.32 12.44 16 42729 765 56248557
Dizziness 36.91 12.44 442 42303 375698 55873624
Thrombocytopenia 36.75 12.44 202 42543 136022 56113300
Rash 36.64 12.44 222 42523 492825 55756497
Cachexia 36.12 12.44 30 42715 4912 56244410
Suspected product quality issue 35.63 12.44 11 42734 201 56249121
Pelvic fracture 35.37 12.44 45 42700 12168 56237154
Hepatitis toxic 35.15 12.44 24 42721 2928 56246394
Musculoskeletal pain 34.95 12.44 138 42607 81014 56168308
Gallbladder polyp 34.89 12.44 15 42730 722 56248600
Somatic symptom disorder 34.78 12.44 21 42724 2074 56247248
Urogenital haemorrhage 33.67 12.44 11 42734 243 56249079
Constipation 33.46 12.44 265 42480 201678 56047644
Prescription drug used without a prescription 33.27 12.44 20 42725 1960 56247362
Spinal pain 33.17 12.44 43 42702 11841 56237481
Facial nerve disorder 32.00 12.44 13 42732 542 56248780
Headache 31.71 12.44 272 42473 558772 55690550
Type I hypersensitivity 31.55 12.44 21 42724 2457 56246865
Therapeutic product effect incomplete 31.33 12.44 21 42724 106010 56143312
Angina pectoris 31.23 12.44 67 42678 27909 56221413
Hypersensitivity 30.93 12.44 96 42649 256312 55993010
Ileus 30.87 12.44 45 42700 13837 56235485
Delirium 30.58 12.44 86 42659 42431 56206891
Gastrointestinal sounds abnormal 29.70 12.44 24 42721 3781 56245541
Bicytopenia 29.41 12.44 19 42726 2114 56247208
Nasal congestion 29.34 12.44 4 42741 56366 56192956
Diverticulum intestinal 29.32 12.44 30 42715 6410 56242912
Faecaloma 29.15 12.44 32 42713 7409 56241913
Psychotic symptom 28.78 12.44 16 42729 1353 56247969
Off label use 28.75 12.44 277 42468 555903 55693419
Respiratory alkalosis 28.63 12.44 20 42725 2531 56246791
Hyponatraemia 28.57 12.44 153 42592 101986 56147336
Therapy non-responder 28.31 12.44 6 42739 61349 56187973
Hospitalisation 27.89 12.44 11 42734 74989 56174333
Injection site erythema 27.76 12.44 12 42733 77436 56171886
Thirst 27.69 12.44 38 42707 11052 56238270
Chromaturia 27.51 12.44 45 42700 15280 56234042
Mucosal haemorrhage 27.46 12.44 14 42731 994 56248328
Psoriatic arthropathy 27.28 12.44 11 42734 73997 56175325
Muscle tone disorder 27.20 12.44 8 42737 123 56249199
Nail toxicity 26.66 12.44 10 42735 336 56248986
Gastrointestinal disorder 26.34 12.44 28 42717 112674 56136648
Hypoaesthesia 26.04 12.44 42 42703 141449 56107873
Post-traumatic pain 25.74 12.44 10 42735 370 56248952
Immobile 25.72 12.44 26 42719 5476 56243846
Vascular encephalopathy 25.39 12.44 10 42735 384 56248938
Hepatic failure 25.33 12.44 69 42676 33417 56215905
Thirst decreased 25.31 12.44 9 42736 259 56249063
Heart rate increased 25.27 12.44 16 42729 83257 56166065
Antineutrophil cytoplasmic antibody positive 25.25 12.44 11 42734 547 56248775
Feeling abnormal 25.21 12.44 39 42706 133563 56115759
Insomnia 25.19 12.44 69 42676 191791 56057531
Blood pressure increased 24.97 12.44 45 42700 145131 56104191
Acute generalised exanthematous pustulosis 24.92 12.44 34 42711 9835 56239487
Hepatic enzyme increased 24.53 12.44 59 42686 171325 56077997
Pseudarthrosis 24.17 12.44 10 42735 437 56248885
Gastric mucosa erythema 24.03 12.44 9 42736 301 56249021
Gastric ulcer 24 12.44 53 42692 22510 56226812
Injury 23.57 12.44 8 42737 59843 56189479
Drug reaction with eosinophilia and systemic symptoms 23.48 12.44 63 42682 30241 56219081
Urinary retention 23.42 12.44 60 42685 28014 56221308
Pleural effusion 23.20 12.44 127 42618 85353 56163969
Injection site reaction 23.00 12.44 6 42739 53241 56196081
Hepatitis acute 22.95 12.44 30 42715 8327 56240995
Therapeutic response decreased 22.68 12.44 6 42739 52752 56196570
Death 22.64 12.44 159 42586 341267 55908055
Device stimulation issue 22.58 12.44 6 42739 62 56249260
Head discomfort 22.55 12.44 36 42709 11978 56237344
Lividity 22.31 12.44 8 42737 236 56249086
Peripheral swelling 22.30 12.44 97 42648 234629 56014693
Gastroenteritis 22.29 12.44 54 42691 24358 56224964
Circulatory collapse 22.28 12.44 49 42696 20754 56228568
Localised infection 22.27 12.44 58 42687 27354 56221968
Foreign body 22.25 12.44 16 42729 2120 56247202
Suspected product contamination 21.98 12.44 5 42740 25 56249297
Dyspnoea exertional 21.95 12.44 91 42654 54598 56194724
Lethargy 21.83 12.44 6 42739 51435 56197887
Vasculitis 21.79 12.44 40 42705 14883 56234439
Myocardial infarction 21.78 12.44 23 42722 92847 56156475
Injection site pruritus 21.76 12.44 3 42742 41928 56207394
Bradycardia 21.59 12.44 105 42640 67399 56181923
Hepatic cyst 21.23 12.44 22 42723 4771 56244551
Paresis 21.20 12.44 16 42729 2282 56247040
Oliguria 21.19 12.44 29 42716 8411 56240911
Hyperkinesia 21.13 12.44 14 42731 1625 56247697
Adverse event 20.79 12.44 8 42737 55368 56193954
Aortic valve stenosis 20.74 12.44 18 42727 3129 56246193
Spontaneous haemorrhage 20.67 12.44 8 42737 293 56249029
Vertigo 20.50 12.44 89 42656 54483 56194839
Pain in jaw 20.46 12.44 3 42742 40033 56209289
Amnesia 20.43 12.44 5 42740 46317 56203005
Paranasal sinus inflammation 20.41 12.44 9 42736 461 56248861
Liver function test increased 20.32 12.44 57 42688 28076 56221246
Coombs negative haemolytic anaemia 20.14 12.44 7 42738 188 56249134
Fluid intake reduced 20.06 12.44 18 42727 3269 56246053
Acute abdomen 19.98 12.44 13 42732 1463 56247859
Urosepsis 19.78 12.44 41 42704 16675 56232647
Medication overuse headache 19.73 12.44 10 42735 701 56248621
Ill-defined disorder 19.68 12.44 14 42731 68529 56180793
Irritable bowel syndrome 19.63 12.44 14 42731 68444 56180878
Transaminases increased 19.53 12.44 57 42688 28713 56220609
Neuropathy peripheral 19.44 12.44 30 42715 102863 56146459
Unevaluable event 19.44 12.44 6 42739 47681 56201641
Cholestatic liver injury 19.29 12.44 15 42730 2237 56247085
Pneumobilia 19.07 12.44 6 42739 117 56249205
Decreased appetite 19.04 12.44 252 42493 218979 56030343
Hypertensive emergency 18.93 12.44 13 42732 1600 56247722
Peritoneal perforation 18.93 12.44 6 42739 120 56249202
Left ventricular hypertrophy 18.77 12.44 21 42724 4963 56244359
Necrotising fasciitis 18.70 12.44 16 42729 2729 56246593
Duodenal ulcer 18.60 12.44 25 42720 7130 56242192
Heart rate decreased 18.56 12.44 4 42741 40423 56208899
Febrile infection 18.32 12.44 12 42733 1366 56247956
Gastritis 18.28 12.44 63 42682 34639 56214683
Chills 18.28 12.44 137 42608 102467 56146855
Spinal osteoarthritis 18.27 12.44 37 42708 14799 56234523
Stoma site inflammation 18.12 12.44 8 42737 411 56248911
Sensory level abnormal 18.10 12.44 6 42739 139 56249183
Inappropriate schedule of product administration 18.08 12.44 22 42723 83365 56165957
Intentional product use issue 17.98 12.44 30 42715 99703 56149619
No adverse event 17.97 12.44 3 42742 36371 56212951
Nail avulsion 17.90 12.44 6 42739 144 56249178
Haematuria 17.87 12.44 53 42692 26934 56222388
Disease progression 17.72 12.44 33 42712 105140 56144182
Sensory disturbance 17.54 12.44 33 42712 12510 56236812
Depressed level of consciousness 17.48 12.44 87 42658 56346 56192976
Metastatic malignant melanoma 17.47 12.44 12 42733 1478 56247844
Peripheral circulatory failure 17.38 12.44 10 42735 903 56248419
Patent ductus arteriosus 17.25 12.44 18 42727 3933 56245389
Loss of personal independence in daily activities 17.09 12.44 22 42723 81347 56167975
Cellulitis 17.09 12.44 19 42726 74930 56174392
Faeces pale 16.92 12.44 12 42733 1555 56247767
Affective disorder 16.79 12.44 21 42724 5582 56243740
Anaemia folate deficiency 16.36 12.44 6 42739 189 56249133
Urogenital infection bacterial 16.20 12.44 4 42741 30 56249292
Internal haemorrhage 16.14 12.44 19 42726 4745 56244577
Electrocardiogram abnormal 16.11 12.44 25 42720 8119 56241203
Dyschezia 16.08 12.44 13 42732 2050 56247272
Leukocytosis 16.01 12.44 47 42698 23744 56225578
Neutropenia 15.95 12.44 187 42558 157980 56091342
Brain contusion 15.94 12.44 8 42737 549 56248773
Peripheral arterial occlusive disease 15.85 12.44 17 42728 3833 56245489
Painful respiration 15.81 12.44 14 42731 2500 56246822
Merycism 15.76 12.44 6 42739 210 56249112
Hyperaemia 15.76 12.44 13 42732 2109 56247213
Migraine 15.74 12.44 26 42719 86771 56162551
Pregnancy 15.72 12.44 3 42742 33030 56216292
C-reactive protein increased 15.71 12.44 108 42637 78576 56170746
Type 2 diabetes mellitus 15.65 12.44 8 42737 46854 56202468
Knee arthroplasty 15.63 12.44 7 42738 44252 56205070
Flank pain 15.63 12.44 34 42711 14291 56235031
Hyperglycaemia 15.59 12.44 64 42681 38217 56211105
Contusion 15.53 12.44 48 42697 128382 56120940
Lumbar vertebral fracture 15.51 12.44 19 42726 4945 56244377
Pulmonary vein occlusion 15.50 12.44 5 42740 106 56249216
Conjunctivitis 15.48 12.44 39 42706 18021 56231301
Arthritis 15.39 12.44 33 42712 99819 56149503
Urinary tract infection enterococcal 15.36 12.44 14 42731 2595 56246727
VIIIth nerve injury 15.26 12.44 3 42742 6 56249316
Cardiac murmur functional 15.17 12.44 4 42741 40 56249282
Abdominal wall cyst 15.00 12.44 4 42741 42 56249280
Bulimia nervosa 14.88 12.44 7 42738 417 56248905
Kyphosis 14.83 12.44 13 42732 2289 56247033
Reticulocyte count increased 14.63 12.44 9 42736 919 56248403
Prerenal failure 14.61 12.44 11 42734 1564 56247758
Hepatitis cholestatic 14.56 12.44 21 42724 6393 56242929
Exposure during pregnancy 14.41 12.44 54 42691 136288 56113034
Necrolytic migratory erythema 14.40 12.44 3 42742 9 56249313
Angioedema 14.36 12.44 66 42679 41387 56207935
Dysphagia 14.35 12.44 109 42636 81838 56167484
Adverse drug reaction 14.32 12.44 17 42728 65115 56184207
Petechiae 14.29 12.44 31 42714 13008 56236314
Coronavirus test positive 14.28 12.44 8 42737 687 56248635
Myoclonus 14.28 12.44 34 42711 15169 56234153
Shock haemorrhagic 14.20 12.44 25 42720 9008 56240314
Lordosis 14.17 12.44 6 42739 278 56249044
Autoimmune colitis 13.93 12.44 7 42738 482 56248840
Gastrointestinal infection 13.93 12.44 23 42722 7871 56241451
Mucosal dryness 13.92 12.44 13 42732 2485 56246837
Cardio-respiratory arrest 13.77 12.44 13 42732 55308 56194014
Metastatic gastric cancer 13.77 12.44 5 42740 153 56249169
Sinobronchitis 13.68 12.44 5 42740 156 56249166
Bone marrow oedema 13.58 12.44 9 42736 1045 56248277
Cerebrovascular accident 13.55 12.44 35 42710 99235 56150087
CD8 lymphocytes decreased 13.50 12.44 5 42740 162 56249160
Chronic fatigue syndrome 13.50 12.44 9 42736 1056 56248266
Surgery 13.40 12.44 4 42741 32482 56216840
Fatigue 13.27 12.44 478 42267 788074 55461248
Upper respiratory tract infection 13.26 12.44 21 42724 71267 56178055
Hyperresponsive to stimuli 13.23 12.44 4 42741 68 56249254
Gastrointestinal tract adenoma 13.17 12.44 6 42739 332 56248990
Systemic inflammatory response syndrome 13.05 12.44 18 42727 5260 56244062
Ileus paralytic 13.01 12.44 16 42729 4179 56245143
Rheumatic fever 12.93 12.44 3 42742 28824 56220498
Unresponsive to stimuli 12.91 12.44 4 42741 31721 56217601
Piloerection 12.79 12.44 6 42739 355 56248967
Cancer fatigue 12.76 12.44 4 42741 77 56249245
Gastric ulcer perforation 12.65 12.44 9 42736 1172 56248150
Peripheral nerve lesion 12.65 12.44 6 42739 364 56248958
Ileal stenosis 12.60 12.44 10 42735 1535 56247787
Normochromic normocytic anaemia 12.55 12.44 16 42729 4333 56244989
Substance dependence 12.53 12.44 5 42740 199 56249123
Acute myocardial infarction 12.53 12.44 51 42694 30342 56218980
Flatulence 12.50 12.44 52 42693 31236 56218086
Dysplasia 12.50 12.44 8 42737 876 56248446

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1353.51 13.84 1041 32041 112394 31551868
Product prescribing error 342.39 13.84 228 32854 19414 31644848
Systemic infection 209.89 13.84 92 32990 3357 31660905
Haematochezia 174.33 13.84 213 32869 40251 31624011
Anaemia 156.99 13.84 534 32548 212988 31451274
Product monitoring error 156.72 13.84 74 33008 3216 31661046
Drug ineffective 152.22 13.84 115 32967 395458 31268804
Abdominal pain 114.11 13.84 373 32709 145579 31518683
Death 95.78 13.84 143 32939 360426 31303836
Musculoskeletal pain 91.42 13.84 133 32949 29695 31634567
Appendicolith 91.36 13.84 63 33019 5668 31658594
Agranulocytosis 86.86 13.84 109 32973 21138 31643124
Completed suicide 82.26 13.84 3 33079 91511 31572751
Abdominal pain upper 77.75 13.84 192 32890 63810 31600452
Pallor 76.12 13.84 105 32977 22319 31641943
Vomiting 74.63 13.84 443 32639 223530 31440732
Leukopenia 74.00 13.84 177 32905 57651 31606611
Nausea 68.77 13.84 552 32530 307395 31356867
Cardiac failure congestive 66.83 13.84 4 33078 79383 31584879
Labelled drug-drug interaction medication error 66.09 13.84 75 33007 13088 31651174
Appendicitis 65.67 13.84 70 33012 11395 31652867
Malaise 64.50 13.84 49 33033 168462 31495800
Tachypnoea 61.76 13.84 81 33001 16402 31647860
Product dose omission issue 61.56 13.84 17 33065 105569 31558693
Micturition disorder 59.10 13.84 33 33049 2040 31662222
Fracture 56.16 13.84 49 33033 6231 31658031
Electrolyte imbalance 55.60 13.84 66 33016 12082 31652180
Acute abdomen 55.00 13.84 30 33052 1771 31662491
Tachycardia 53.44 13.84 188 32894 76019 31588243
Constipation 52.48 13.84 262 32820 123729 31540533
Dyspnoea 51.64 13.84 566 32516 342913 31321349
Neuropathy peripheral 44.41 13.84 12 33070 75637 31588625
Paresis 44.38 13.84 27 33055 1960 31662302
Negative pressure pulmonary oedema 43.59 13.84 14 33068 209 31664053
Dyschezia 43.55 13.84 23 33059 1272 31662990
Blood pressure measurement 42.41 13.84 13 33069 165 31664097
Electrocardiogram abnormal 40.70 13.84 46 33036 7990 31656272
Restlessness 40.68 13.84 81 33001 23280 31640982
Neuromuscular block prolonged 40.49 13.84 16 33066 447 31663815
Pyrexia 39.92 13.84 488 32594 303352 31360910
Polyneuropathy 39.78 13.84 58 33024 12964 31651298
Myocardial infarction 39.65 13.84 36 33046 113418 31550844
Hyponatraemia 38.61 13.84 166 32916 73633 31590629
Toxicity to various agents 38.10 13.84 83 32999 181404 31482858
Oedema peripheral 37.56 13.84 219 32863 109620 31554642
Mucosal haemorrhage 36.97 13.84 22 33060 1534 31662728
Disturbance in attention 36.90 13.84 76 33006 22374 31641888
C-reactive protein increased 36.68 13.84 123 32959 48527 31615735
Abdominal distension 36.34 13.84 126 32956 50558 31613704
Blood phosphorus increased 36.16 13.84 33 33049 4449 31659813
Therapeutic drug monitoring analysis not performed 35.62 13.84 15 33067 495 31663767
Cachexia 35.14 13.84 39 33043 6640 31657622
Malignant neoplasm progression 34.86 13.84 169 32913 78829 31585433
Impaired healing 34.83 13.84 57 33025 14075 31650187
Platelet dysfunction 34.39 13.84 12 33070 234 31664028
Product administration error 34.26 13.84 59 33023 15188 31649074
Fall 33.75 13.84 319 32763 185770 31478492
Interstitial lung disease 33.74 13.84 11 33071 61392 31602870
Gamma-glutamyltransferase increased 33.25 13.84 83 32999 27742 31636520
Hospitalisation 33.06 13.84 6 33076 49801 31614461
Ventricular fibrillation 32.39 13.84 65 33017 18783 31645479
Treatment failure 31.64 13.84 3 33079 40789 31623473
Medication error 31.61 13.84 72 33010 22700 31641562
Platelet count decreased 30.94 13.84 42 33040 110393 31553869
Drug abuse 30.47 13.84 28 33054 87730 31576532
Stress 30.43 13.84 75 33007 24866 31639396
Wound 30.33 13.84 51 33031 12877 31651385
Cardiogenic shock 30.16 13.84 70 33012 22338 31641924
Hypertensive crisis 30.07 13.84 40 33042 8207 31656055
Weight bearing difficulty 29.45 13.84 16 33066 937 31663325
Respiratory tract haemorrhage 29.25 13.84 17 33065 1134 31663128
Leptotrichia infection 28.29 13.84 8 33074 75 31664187
Drug reaction with eosinophilia and systemic symptoms 28.27 13.84 82 33000 29936 31634326
Blood pressure increased 28.13 13.84 25 33057 79608 31584654
Internal fixation of fracture 27.57 13.84 8 33074 83 31664179
Infusion related reaction 27.50 13.84 8 33074 48047 31616215
Accessory spleen 27.45 13.84 9 33073 144 31664118
Toxic epidermal necrolysis 27.39 13.84 62 33020 19462 31644800
Ascites 26.86 13.84 99 32983 40914 31623348
Feeling abnormal 26.75 13.84 13 33069 56989 31607273
Erysipelas 26.63 13.84 28 33054 4485 31659777
Dizziness 26.56 13.84 321 32761 198826 31465436
Haematemesis 26.03 13.84 72 33010 25581 31638681
Cardiac arrest 25.83 13.84 33 33049 89029 31575233
Gastrointestinal adenocarcinoma 25.63 13.84 7 33075 57 31664205
Disease progression 24.74 13.84 35 33047 90429 31573833
Suspected product contamination 24.63 13.84 7 33075 67 31664195
Hydrocholecystis 24.30 13.84 10 33072 311 31663951
Hyperventilation 23.34 13.84 20 33062 2481 31661781
Urosepsis 23.30 13.84 43 33039 11677 31652585
Multiple organ dysfunction syndrome 23.29 13.84 136 32946 68067 31596195
Thrombosis 23.25 13.84 9 33073 45142 31619120
Iris adhesions 23.20 13.84 9 33073 239 31664023
Pain 23.16 13.84 297 32785 186462 31477800
Condition aggravated 23.01 13.84 267 32815 163742 31500520
Psoriasis 22.94 13.84 10 33072 46709 31617553
Therapeutic product effect decreased 22.82 13.84 3 33079 31619 31632643
Haematoma 22.78 13.84 66 33016 24073 31640189
Cold sweat 22.50 13.84 37 33045 9172 31655090
Joint swelling 22.44 13.84 14 33068 53417 31610845
Long QT syndrome 22.31 13.84 19 33063 2337 31661925
Hepatorenal failure 22.17 13.84 11 33071 533 31663729
Depressed level of consciousness 21.87 13.84 89 32993 38512 31625750
Implant site inflammation 21.76 13.84 7 33075 105 31664157
Tension headache 21.29 13.84 15 33067 1396 31662866
Abdominal discomfort 20.99 13.84 14 33068 51553 31612709
Adenocarcinoma of appendix 20.96 13.84 7 33075 119 31664143
Intestinal haemorrhage 20.57 13.84 21 33061 3250 31661012
Contraindicated product administered 20.56 13.84 56 33026 19716 31644546
Therapy non-responder 20.53 13.84 5 33077 33806 31630456
Angioedema 20.23 13.84 79 33003 33539 31630723
Cardiovascular insufficiency 20.17 13.84 15 33067 1519 31662743
Labelled drug-drug interaction issue 20.16 13.84 8 33074 226 31664036
Pseudarthrosis 19.73 13.84 6 33076 74 31664188
Product prescribing issue 19.68 13.84 15 33067 1576 31662686
Osteochondrosis 19.57 13.84 12 33070 883 31663379
Suspected product quality issue 19.45 13.84 7 33075 150 31664112
Thirst 19.33 13.84 29 33053 6647 31657615
Tracheal atresia 19.08 13.84 4 33078 8 31664254
Mineral supplementation 19.04 13.84 6 33076 84 31664178
Lack of application site rotation 18.76 13.84 4 33078 9 31664253
Spinal pain 18.64 13.84 25 33057 5170 31659092
Pulmonary sepsis 18.59 13.84 16 33066 1996 31662266
Coma 18.39 13.84 10 33072 41140 31623122
Immobile 18.31 13.84 17 33065 2343 31661919
Febrile infection 18.25 13.84 16 33066 2046 31662216
Genitourinary tract infection 18.18 13.84 6 33076 98 31664164
Chronic fatigue syndrome 18.09 13.84 8 33074 298 31663964
Hepatic cyst 18.08 13.84 17 33065 2381 31661881
Dysdiadochokinesis 17.83 13.84 7 33075 192 31664070
Platelet function test abnormal 17.75 13.84 6 33076 106 31664156
Unevaluable event 17.65 13.84 5 33077 30570 31633692
Heart rate decreased 17.52 13.84 4 33078 28262 31636000
Unresponsive to stimuli 17.35 13.84 3 33079 25797 31638465
Flushing 17.26 13.84 5 33077 30123 31634139
Adrenocortical insufficiency acute 17.25 13.84 13 33069 1343 31662919
Autoimmune nephritis 17.21 13.84 7 33075 211 31664051
Musculoskeletal stiffness 17.12 13.84 11 33071 41314 31622948
Vertigo 17.06 13.84 58 33024 23027 31641235
Gastritis haemorrhagic 17.00 13.84 13 33069 1372 31662890
Toxic neuropathy 16.97 13.84 9 33073 502 31663760
Flank pain 16.93 13.84 26 33056 6083 31658179
Urogenital infection bacterial 16.88 13.84 5 33077 56 31664206
Cardiac disorder 16.85 13.84 10 33072 39204 31625058
Anxiety disorder 16.73 13.84 14 33068 1681 31662581
Reflux nephropathy 16.65 13.84 5 33077 59 31664203
Drug intolerance 16.45 13.84 18 33064 52015 31612247
Tonsillitis 16.11 13.84 15 33067 2075 31662187
Blood folate increased 16.08 13.84 7 33075 251 31664011
Paraparesis 15.96 13.84 14 33068 1792 31662470
Spinal cord injury cauda equina 15.96 13.84 6 33076 146 31664116
White blood cell count decreased 15.91 13.84 43 33039 87355 31576907
Orthostatic hypotension 15.80 13.84 3 33079 24116 31640146
Lung disorder 15.73 13.84 7 33075 32305 31631957
Jaundice 15.72 13.84 68 33014 30219 31634043
Cardiovascular disorder 15.70 13.84 32 33050 9346 31654916
Somatosensory evoked potentials abnormal 15.66 13.84 6 33076 154 31664108
Loss of personal independence in daily activities 15.65 13.84 5 33077 28283 31635979
Influenza 15.54 13.84 14 33068 44311 31619951
Breath sounds normal 15.52 13.84 3 33079 3 31664259
Swelling 15.40 13.84 10 33072 37348 31626914
Cerebrovascular accident 15.32 13.84 38 33044 79446 31584816
Thrombocytopenia 15.21 13.84 221 32861 142526 31521736
Drug resistance 15.19 13.84 3 33079 23450 31640812
Disorientation 15.18 13.84 68 33014 30676 31633586
Nail bed inflammation 15.14 13.84 6 33076 169 31664093
Haemorrhagic necrotic pancreatitis 15.10 13.84 6 33076 170 31664092
Lower gastrointestinal haemorrhage 14.97 13.84 30 33052 8659 31655603
Anxiety 14.97 13.84 47 33035 90986 31573276
Fear of disease 14.93 13.84 7 33075 299 31663963
Oedematous pancreatitis 14.86 13.84 8 33074 460 31663802
Coronavirus test positive 14.75 13.84 8 33074 467 31663795
Vitamin B6 deficiency 14.69 13.84 6 33076 183 31664079
Rectal haemorrhage 14.58 13.84 10 33072 36294 31627968
Food interaction 14.52 13.84 10 33072 897 31663365
Mycobacterium fortuitum infection 14.48 13.84 6 33076 190 31664072
Product packaging confusion 14.39 13.84 4 33078 35 31664227
Upper gastrointestinal haemorrhage 14.37 13.84 55 33027 23128 31641134
Primary biliary cholangitis 14.27 13.84 6 33076 197 31664065
Autoimmune hepatitis 14.27 13.84 19 33063 3901 31660361
Fear of falling 14.27 13.84 7 33075 331 31663931
Anal haemorrhage 14.26 13.84 15 33067 2403 31661859
Preternatural anus 14.21 13.84 5 33077 100 31664162
Psychotic disorder 14.13 13.84 3 33079 22290 31641972
Renal impairment 14.13 13.84 145 32937 86204 31578058
Therapeutic response decreased 14.12 13.84 5 33077 26504 31637758
Seizure 14.06 13.84 55 33027 99713 31564549
Target skin lesion 13.99 13.84 3 33079 7 31664255
Respiratory arrest 13.91 13.84 5 33077 26252 31638010
Oral herpes 13.87 13.84 21 33061 4852 31659410

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 2666.88 12.06 2030 66246 234001 70626167
Product prescribing error 883.97 12.06 519 67757 38433 70821735
Haematochezia 480.90 12.06 463 67813 72618 70787550
Systemic infection 443.76 12.06 185 68091 6472 70853696
Anaemia 436.34 12.06 1099 67177 402324 70457844
Product monitoring error 410.69 12.06 176 68100 6600 70853568
Agranulocytosis 304.77 12.06 276 68000 40022 70820146
Drug ineffective 271.77 12.06 304 67972 939448 69920720
Fracture 235.56 12.06 177 68099 19767 70840401
Labelled drug-drug interaction medication error 179.93 12.06 164 68112 23963 70836205
Pallor 174.17 12.06 206 68070 40768 70819400
Abdominal pain 171.27 12.06 717 67559 341410 70518758
Leukopenia 156.22 12.06 328 67948 106232 70753936
Haematemesis 156.17 12.06 213 68063 48584 70811584
Completed suicide 153.52 12.06 19 68257 227116 70633052
Vomiting 149.64 12.06 1029 67247 592082 70268086
Joint swelling 143.09 12.06 34 68242 253177 70606991
Nausea 140.47 12.06 1341 66935 850747 70009421
Abdominal pain upper 138.93 12.06 456 67820 193146 70667022
Fall 137.54 12.06 812 67464 443284 70416884
Aspirin-exacerbated respiratory disease 135.21 12.06 49 68227 1166 70859002
Malaise 134.74 12.06 131 68145 432801 70427367
Restlessness 131.96 12.06 182 68094 41946 70818222
Dyspnoea 130.83 12.06 1220 67056 768840 70091328
Tachypnoea 130.09 12.06 149 68127 28489 70831679
Polyneuropathy 128.27 12.06 129 68147 21286 70838882
Product dose omission issue 127.28 12.06 27 68249 217441 70642727
Product administration error 119.82 12.06 145 68131 29378 70830790
Infusion related reaction 118.77 12.06 23 68253 197511 70662657
Musculoskeletal pain 118.62 12.06 266 68010 90061 70770107
Rheumatoid arthritis 116.77 12.06 68 68208 291737 70568431
Electrolyte imbalance 112.41 12.06 134 68142 26727 70833441
Abdominal discomfort 109.70 12.06 35 68241 214623 70645545
Tachycardia 103.60 12.06 362 67914 158184 70701984
Treatment failure 102.57 12.06 10 68266 144132 70716036
Synovitis 100.31 12.06 6 68270 129222 70730946
Constipation 94.31 12.06 486 67790 251952 70608216
Therapeutic product effect decreased 94.11 12.06 13 68263 143005 70717163
Appendicolith 94.05 12.06 62 68214 5618 70854550
Arthropathy 93.36 12.06 16 68260 150041 70710127
Toxic epidermal necrolysis 91.09 12.06 148 68128 39409 70820759
Cardiac failure congestive 87.52 12.06 13 68263 135444 70724724
Sinusitis 87.48 12.06 27 68249 169168 70691000
Oedema peripheral 86.48 12.06 441 67835 227650 70632518
Erysipelas 83.01 12.06 72 68204 9852 70850316
Pyrexia 82.34 12.06 919 67357 606033 70254135
Disturbance in attention 81.03 12.06 147 68129 42747 70817421
Drug intolerance 80.23 12.06 60 68216 225627 70634541
Musculoskeletal stiffness 79.28 12.06 22 68254 147738 70712430
Abdominal pain lower 78.18 12.06 115 68161 28101 70832067
Swelling 78.16 12.06 42 68234 188497 70671671
Therapeutic drug monitoring analysis not performed 77.06 12.06 35 68241 1509 70858659
Lower respiratory tract infection 74.03 12.06 10 68266 111903 70748265
Medication error 74.01 12.06 167 68109 56745 70803423
Gamma-glutamyltransferase increased 70.74 12.06 153 68123 50532 70809636
Renal impairment 70.50 12.06 300 67976 143637 70716531
Injection site pain 70.03 12.06 14 68262 117605 70742563
Jaundice 69.64 12.06 151 68125 49957 70810211
Ascites 69.43 12.06 181 68095 67366 70792802
Cachexia 69.35 12.06 65 68211 9835 70850333
Malignant neoplasm progression 68.58 12.06 265 68011 121474 70738694
Blood pressure increased 68.44 12.06 49 68227 188468 70671700
Haematoma 67.39 12.06 146 68130 48272 70811896
Pemphigus 63.99 12.06 4 68272 83032 70777136
Paresis 63.48 12.06 42 68234 3828 70856340
Dehydration 62.52 12.06 402 67874 225740 70634428
Acute abdomen 61.49 12.06 37 68239 2857 70857311
Death 61.10 12.06 268 68008 509793 70350375
Drug-induced liver injury 60.39 12.06 153 68123 55960 70804208
Osteochondrosis 60.22 12.06 30 68246 1593 70858575
Hepatorenal failure 59.10 12.06 27 68249 1180 70858988
Systemic lupus erythematosus 58.87 12.06 13 68263 101889 70758279
Electrocardiogram abnormal 57.83 12.06 71 68205 14593 70845575
Apathy 57.55 12.06 64 68212 11844 70848324
Dizziness 57.55 12.06 691 67585 463450 70396718
Suspected product quality issue 56.97 12.06 18 68258 277 70859891
Lethargy 56.89 12.06 4 68272 75246 70784922
Psoriasis 55.98 12.06 13 68263 98420 70761748
Appendicitis 54.97 12.06 74 68202 16659 70843509
Hyponatraemia 54.78 12.06 301 67975 159786 70700382
Dysuria 54.73 12.06 130 68146 45664 70814504
Nasopharyngitis 54.37 12.06 81 68195 222125 70638043
Mucosal haemorrhage 54.31 12.06 32 68244 2377 70857791
Drug hypersensitivity 53.87 12.06 107 68169 262352 70597816
Pericarditis 52.74 12.06 9 68267 84696 70775472
Abdominal distension 51.89 12.06 219 68057 104450 70755718
Dyschezia 51.75 12.06 32 68244 2595 70857573
Upper gastrointestinal haemorrhage 51.00 12.06 112 68164 37365 70822803
Myocardial infarction 50.93 12.06 54 68222 171591 70688577
Feeling abnormal 50.34 12.06 38 68238 142281 70717887
Interstitial lung disease 50.12 12.06 19 68257 104666 70755502
Acute hepatic failure 49.95 12.06 93 68183 27579 70832589
Drug reaction with eosinophilia and systemic symptoms 49.26 12.06 145 68131 57868 70802300
Mental status changes 48.74 12.06 3 68273 63098 70797070
Arthralgia 48.59 12.06 285 67991 503105 70357063
Toxicity to various agents 48.06 12.06 197 68079 381975 70478193
Alopecia 47.93 12.06 73 68203 198417 70661751
Micturition disorder 46.48 12.06 34 68242 3641 70856527
Suspected product contamination 46.12 12.06 12 68264 87 70860081
Syncope 45.41 12.06 294 67982 165415 70694753
Tumour pain 45.03 12.06 27 68249 2071 70858097
Nasal disorder 44.98 12.06 32 68244 3282 70856886
Maternal exposure during pregnancy 44.51 12.06 28 68248 115317 70744851
Negative pressure pulmonary oedema 44.46 12.06 14 68262 213 70859955
Therapy non-responder 44.05 12.06 10 68266 76905 70783263
Subileus 43.87 12.06 38 68238 5189 70854979
Neuropathy peripheral 43.46 12.06 35 68241 126861 70733307
Thrombocytopenia 43.40 12.06 385 67891 238725 70621443
Hypokalaemia 43.09 12.06 244 68032 130944 70729224
Product use issue 42.65 12.06 67 68209 179870 70680298
Thirst 42.46 12.06 61 68215 14588 70845580
Immobile 42.37 12.06 41 68235 6453 70853715
Haemorrhagic erosive gastritis 42.21 12.06 17 68259 543 70859625
Stevens-Johnson syndrome 41.90 12.06 101 68175 35806 70824362
Pancytopenia 40.13 12.06 266 68010 150841 70709327
Gastritis erosive 40.01 12.06 49 68227 10046 70850122
Product used for unknown indication 39.99 12.06 23 68253 1633 70858535
Spinal pain 39.41 12.06 57 68219 13713 70846455
Helicobacter infection 39.21 12.06 4 68272 55652 70804516
Nasal congestion 38.70 12.06 8 68268 65664 70794504
Disease progression 38.42 12.06 57 68219 156615 70703553
Hospitalisation 37.86 12.06 16 68260 82552 70777616
Type I hypersensitivity 37.27 12.06 30 68246 3702 70856466
Cellulitis 36.83 12.06 25 68251 98903 70761265
Arrhythmia 36.45 12.06 128 68148 56015 70804153
Chills 35.54 12.06 250 68026 144536 70715632
Respiratory arrest 35.23 12.06 5 68271 53928 70806240
Platelet count decreased 34.57 12.06 75 68201 178147 70682021
Listless 34.23 12.06 28 68248 3535 70856633
Therapeutic product effect incomplete 34.13 12.06 39 68237 119843 70740325
Hypoaesthesia 33.88 12.06 60 68216 153679 70706489
Heart rate decreased 33.69 12.06 9 68267 62006 70798162
Urogenital haemorrhage 33.43 12.06 16 68260 778 70859390
Febrile infection 33.21 12.06 26 68250 3083 70857085
Multiple organ dysfunction syndrome 33.14 12.06 198 68078 108317 70751851
Heart rate increased 33.06 12.06 32 68244 106116 70754052
Haematuria 33.05 12.06 135 68141 63438 70796730
Depressed level of consciousness 33.04 12.06 169 68107 87262 70772906
Drug interaction 33.02 12.06 533 67743 380908 70479260
Bradycardia 32.86 12.06 219 68057 124396 70735772
Blood pressure measurement 32.67 12.06 13 68263 402 70859766
Gastrointestinal disorder 32.59 12.06 32 68244 105395 70754773
Faecaloma 32.48 12.06 45 68231 10406 70849762
Psoriatic arthropathy 32.29 12.06 11 68265 64760 70795408
Urogenital infection bacterial 31.85 12.06 9 68267 92 70860076
Discomfort 31.45 12.06 33 68243 105403 70754765
Rash 31.44 12.06 327 67949 510235 70349933
Hypersensitivity 31.07 12.06 115 68161 229697 70630471
Weight increased 31 12.06 124 68152 242207 70617961
Loss of personal independence in daily activities 30.89 12.06 22 68254 84888 70775280
Injection site swelling 30.67 12.06 3 68273 43154 70817014
Flank pain 30.56 12.06 58 68218 17444 70842724
Hepatitis acute 30.46 12.06 51 68225 13911 70846257
Irritable bowel syndrome 30.37 12.06 6 68270 50844 70809324
Pain in jaw 30.23 12.06 3 68273 42666 70817502
Drug abuse 30.22 12.06 60 68216 147196 70712972
Folliculitis 30.15 12.06 3 68273 42567 70817601
Off label use 30.08 12.06 519 67757 742541 70117627
Platelet dysfunction 29.72 12.06 12 68264 386 70859782
Chronic fatigue syndrome 29.58 12.06 17 68259 1205 70858963
Disorientation 29.32 12.06 122 68154 57801 70802367
Unresponsive to stimuli 29.24 12.06 7 68269 51924 70808244
Injection site erythema 29.11 12.06 17 68259 72907 70787261
Coronavirus test positive 28.85 12.06 16 68260 1059 70859109
Urosepsis 28.62 12.06 68 68208 23881 70836287
Pelvic fracture 28.49 12.06 44 68232 11217 70848951
Adverse drug reaction 28.49 12.06 8 68268 53336 70806832
Contusion 28.18 12.06 50 68226 127986 70732182
Reduced facial expression 28.04 12.06 21 68255 2331 70857837
Peripheral swelling 27.82 12.06 125 68151 236438 70623730
C-reactive protein increased 27.80 12.06 192 68084 110325 70749843
Angina pectoris 27.77 12.06 106 68170 48277 70811891
Neuromuscular block prolonged 27.40 12.06 15 68261 968 70859200
Cardio-respiratory arrest 27.33 12.06 34 68242 100643 70759525
Therapeutic response decreased 27.33 12.06 11 68265 58442 70801726
Blood phosphorus increased 27.05 12.06 33 68243 6737 70853431
Respiratory tract haemorrhage 26.88 12.06 18 68258 1674 70858494
Fluid intake reduced 26.86 12.06 30 68246 5577 70854591
Accessory spleen 26.48 12.06 9 68267 176 70859992
Blood pressure fluctuation 26.16 12.06 12 68264 59000 70801168
Facial nerve disorder 25.98 12.06 13 68263 697 70859471
Fibromyalgia 25.90 12.06 7 68269 47867 70812301
Flatulence 25.61 12.06 88 68188 38093 70822075
Bicytopenia 25.47 12.06 25 68251 4003 70856165
Angioedema 25.33 12.06 129 68147 66481 70793687
Hepatic cyst 25.31 12.06 29 68247 5542 70854626
Delirium 25.30 12.06 140 68136 74474 70785694
Cardiac arrest 25.01 12.06 75 68201 159759 70700409
Gastritis haemorrhagic 24.94 12.06 20 68256 2454 70857714
Vertigo 24.30 12.06 122 68154 62521 70797647
Ventricular fibrillation 24.20 12.06 69 68207 27042 70833126
Flushing 24.19 12.06 26 68250 82146 70778022
Decreased appetite 24.19 12.06 420 67856 304360 70555808
Unevaluable event 24.01 12.06 10 68266 52053 70808115
Nail toxicity 23.97 12.06 10 68266 350 70859818
Injection site reaction 23.94 12.06 9 68267 49843 70810325
Drug resistance 23.90 12.06 4 68272 38186 70821982
Orthostatic hypotension 23.76 12.06 10 68266 51733 70808435
Cardiac disorder 23.50 12.06 14 68262 59401 70800767
Psychotic disorder 23.48 12.06 4 68272 37697 70822471
Hydrocholecystis 23.45 12.06 10 68266 370 70859798
Long QT syndrome 22.98 12.06 27 68249 5300 70854868
Ileus 22.92 12.06 63 68213 24174 70835994
Depression 22.88 12.06 106 68170 198868 70661300
Type 2 diabetes mellitus 22.83 12.06 7 68269 44073 70816095
Wound 22.78 12.06 168 68108 98564 70761604
Inappropriate schedule of product administration 22.78 12.06 43 68233 107512 70752656
Blood pressure decreased 22.71 12.06 33 68243 91482 70768686
Post-traumatic pain 22.70 12.06 10 68266 401 70859767
Cerebrovascular accident 22.68 12.06 67 68209 143403 70716765
Gallbladder polyp 22.64 12.06 13 68263 920 70859248
Thirst decreased 22.63 12.06 9 68267 278 70859890
White blood cell count decreased 22.42 12.06 86 68190 170055 70690113
Exposure during pregnancy 22.40 12.06 31 68245 87686 70772482
Migraine 22.24 12.06 22 68254 72216 70787952
Hepatitis cholestatic 22.19 12.06 42 68234 12608 70847560
Acute generalised exanthematous pustulosis 22.07 12.06 47 68229 15350 70844818
Sepsis 21.99 12.06 344 67932 244201 70615967
Gastritis 21.85 12.06 93 68183 44498 70815670
Pulmonary sepsis 21.80 12.06 21 68255 3286 70856882
Dysdiadochokinesis 21.71 12.06 9 68267 310 70859858
Oliguria 21.64 12.06 46 68230 15005 70845163
Disease recurrence 21.31 12.06 5 68271 37598 70822570
Muscle tone disorder 21.19 12.06 7 68269 125 70860043
Hyperventilation 20.94 12.06 30 68246 7156 70853012
Blood folate increased 20.78 12.06 10 68266 492 70859676
Coombs negative haemolytic anaemia 20.76 12.06 9 68267 347 70859821
Hepatic function abnormal 20.60 12.06 21 68255 67975 70792193
Tension headache 20.50 12.06 21 68255 3540 70856628
Full blood count abnormal 20.22 12.06 4 68272 33874 70826294
Hypertensive crisis 20.17 12.06 52 68224 19210 70840958
Cardiac failure 20.09 12.06 219 68057 143322 70716846
Hypoxia 20.05 12.06 37 68239 93307 70766861
Duodenal ulcer 20.04 12.06 45 68231 15235 70844933
Transaminases increased 19.98 12.06 94 68182 46924 70813244
Haemorrhagic necrotic pancreatitis 19.96 12.06 7 68269 151 70860017
Prescription drug used without a prescription 19.70 12.06 19 68257 2978 70857190
Pseudarthrosis 19.37 12.06 8 68268 273 70859895
Vascular encephalopathy 19.37 12.06 10 68266 573 70859595
Hepatitis toxic 19.33 12.06 23 68253 4576 70855592
Atrial fibrillation 19.18 12.06 266 68010 184082 70676086
Adverse event 19.08 12.06 12 68264 49449 70810719
Hyperglycaemia 18.47 12.06 116 68160 64556 70795612
Head injury 18.46 12.06 5 68271 34136 70826032
Anxiety 18.02 12.06 131 68145 220199 70639969
Cardiogenic shock 18.00 12.06 76 68200 36231 70823937
Pneumobilia 17.76 12.06 7 68269 211 70859957
Internal fixation of fracture 17.74 12.06 8 68268 339 70859829
Gastric ulcer perforation 17.68 12.06 15 68261 1992 70858176
Ill-defined disorder 17.63 12.06 16 68260 54725 70805443
Gastrointestinal sounds abnormal 17.57 12.06 23 68253 5038 70855130
Spontaneous haemorrhage 17.52 12.06 9 68267 510 70859658
Implant site inflammation 17.43 12.06 7 68269 222 70859946
Product packaging confusion 17.37 12.06 7 68269 224 70859944
Lack of application site rotation 17.17 12.06 4 68272 17 70860151
Oropharyngeal discomfort 17.16 12.06 25 68251 6054 70854114
Amnesia 17.09 12.06 15 68261 52140 70808028
Anaemia of malignant disease 17.09 12.06 10 68266 733 70859435
Pulmonary hypertension 17.00 12.06 12 68264 46524 70813644
Tonsillitis 16.97 12.06 25 68251 6115 70854053
Intentional product use issue 16.96 12.06 59 68217 120083 70740085
Localised infection 16.90 12.06 70 68206 33088 70827080
Medication overuse headache 16.90 12.06 10 68266 749 70859419
Acute kidney injury 16.86 12.06 586 67690 474038 70386130
Hyperaemia 16.75 12.06 17 68259 2834 70857334
Somnolence 16.69 12.06 296 67980 215310 70644858
Paraparesis 16.67 12.06 19 68257 3610 70856558
Lividity 16.56 12.06 8 68268 397 70859771
Bulimia nervosa 16.47 12.06 7 68269 257 70859911
International normalised ratio increased 16.46 12.06 33 68243 80693 70779475
Seizure 16.46 12.06 102 68174 177860 70682308
Weight bearing difficulty 16.45 12.06 17 68259 2895 70857273
Spinal cord injury cauda equina 16.43 12.06 6 68270 146 70860022
Rash pruritic 16.34 12.06 22 68254 62969 70797199
Concomitant disease aggravated 16.25 12.06 36 68240 12078 70848090
Hypervolaemia 16.21 12.06 9 68267 39697 70820471
Autoimmune nephritis 16.11 12.06 9 68267 604 70859564
Antineutrophil cytoplasmic antibody positive 15.94 12.06 11 68265 1075 70859093
Joint stiffness 15.83 12.06 7 68269 35169 70824999
Breath sounds normal 15.76 12.06 3 68273 3 70860165
Drain site complication 15.76 12.06 3 68273 3 70860165
Lower gastrointestinal haemorrhage 15.69 12.06 40 68236 14680 70845488
Fluid retention 15.59 12.06 23 68253 63362 70796806
Peritoneal perforation 15.57 12.06 6 68270 170 70859998
Vitamin B6 deficiency 15.41 12.06 7 68269 302 70859866
Arthritis 15.31 12.06 46 68230 97934 70762234
Visual acuity reduced 15.27 12.06 4 68272 27926 70832242
Product impurity 15.20 12.06 5 68271 88 70860080
Knee arthroplasty 15.17 12.06 7 68269 34294 70825874
Somatosensory evoked potentials abnormal 15.16 12.06 6 68270 183 70859985
Prescribed underdose 14.96 12.06 50 68226 21335 70838833
Respiratory alkalosis 14.95 12.06 19 68257 4042 70856126
Throat tightness 14.84 12.06 3 68273 25019 70835149
Lordosis 14.69 12.06 7 68269 337 70859831
Therapy interrupted 14.66 12.06 3 68273 24799 70835369
Peritoneal adhesions 14.61 12.06 7 68269 341 70859827
Preternatural anus 14.61 12.06 5 68271 100 70860068
Necrotising fasciitis 14.56 12.06 22 68254 5504 70854664
Head discomfort 14.52 12.06 36 68240 12987 70847181
Skin haemorrhage 14.51 12.06 31 68245 10149 70850019
Blood uric acid increased 14.42 12.06 29 68247 9100 70851068
Subacute hepatic failure 14.41 12.06 6 68270 209 70859959
Circulatory collapse 14.40 12.06 70 68206 35404 70824764
Colitis 14.39 12.06 108 68168 63706 70796462
Cardiac murmur functional 14.33 12.06 4 68272 39 70860129
Hyperkinesia 14.25 12.06 15 68261 2608 70857560
Oedematous pancreatitis 14.25 12.06 10 68266 1003 70859165
Rhabdomyolysis 14.22 12.06 46 68230 95714 70764454
Condition aggravated 14.20 12.06 524 67752 427111 70433057
Wrong technique in product usage process 14.08 12.06 28 68248 68670 70791498
Foreign body 14.04 12.06 15 68261 2653 70857515
C-reactive protein abnormal 14.02 12.06 10 68266 38569 70821599
Mycobacterium fortuitum infection 14.02 12.06 6 68270 224 70859944
Influenza 14.01 12.06 59 68217 113641 70746527
Cross sensitivity reaction 13.97 12.06 17 68259 3461 70856707
Vasculitis 13.93 12.06 46 68230 19512 70840656
Solar dermatitis 13.87 12.06 6 68270 230 70859938
Hepatic failure 13.83 12.06 99 68177 57526 70802642
Peripheral circulatory failure 13.82 12.06 10 68266 1053 70859115
Abdominal wall cyst 13.81 12.06 4 68272 45 70860123
Pregnancy 13.80 12.06 3 68273 23778 70836390
Urine uric acid decreased 13.76 12.06 5 68271 120 70860048
Wrong product administered 13.75 12.06 27 68249 8324 70851844
Tracheal pain 13.73 12.06 4 68272 46 70860122
Necrolytic migratory erythema 13.69 12.06 3 68273 9 70860159
Rhinorrhoea 13.64 12.06 27 68249 66344 70793824
Acute respiratory distress syndrome 13.36 12.06 12 68264 41242 70818926
Stenosis 13.32 12.06 13 68263 2068 70858100
Pulmonary vein occlusion 13.31 12.06 5 68271 132 70860036
Diarrhoea 13.27 12.06 899 67377 782442 70077726
Lumbar vertebral fracture 13.24 12.06 22 68254 5965 70854203
Genitourinary tract infection 13.16 12.06 6 68270 261 70859907
Insomnia 13.16 12.06 140 68136 217666 70642502
Leukocytosis 13.16 12.06 74 68202 39594 70820574
Intestinal haemorrhage 13.15 12.06 22 68254 5998 70854170
Toxic neuropathy 13.14 12.06 9 68267 869 70859299
Tumour haemorrhage 13.05 12.06 17 68259 3705 70856463
Coma 13.03 12.06 45 68231 91799 70768369
Urinary sediment abnormal 13.03 12.06 5 68271 140 70860028
Leptotrichia infection 13.01 12.06 4 68272 56 70860112
Lung disorder 12.84 12.06 30 68246 69454 70790714
Hyperresponsive to stimuli 12.82 12.06 4 68272 59 70860109
Sensory level abnormal 12.80 12.06 5 68271 147 70860021
Skin irritation 12.79 12.06 29 68247 9880 70850288
Drug ineffective for unapproved indication 12.73 12.06 11 68265 38527 70821641
Petechiae 12.69 12.06 44 68232 19128 70841040
Organic brain syndrome 12.68 12.06 7 68269 459 70859709
Confusional state 12.65 12.06 195 68081 284203 70575965
Anal haemorrhage 12.65 12.06 17 68259 3819 70856349
Viral infection 12.63 12.06 11 68265 38380 70821788
Reactive gastropathy 12.60 12.06 7 68269 465 70859703
Alpha 2 globulin increased 12.56 12.06 5 68271 155 70860013
Polyneuropathy in malignant disease 12.56 12.06 5 68271 155 70860013
Dyspnoea exertional 12.55 12.06 123 68153 78307 70781861
Vision blurred 12.52 12.06 48 68228 94936 70765232
Rash erythematous 12.49 12.06 19 68257 51699 70808469
Anaemia folate deficiency 12.42 12.06 6 68270 298 70859870
Pure white cell aplasia 12.40 12.06 4 68272 66 70860102
Cytomegalovirus infection 12.36 12.06 12 68264 39746 70820422
Product prescribing issue 12.35 12.06 15 68261 3049 70857119
Adrenocortical insufficiency acute 12.32 12.06 14 68262 2652 70857516
Food interaction 12.21 12.06 11 68265 1582 70858586
No adverse event 12.13 12.06 8 68268 32145 70828023
Brain contusion 12.08 12.06 10 68266 1284 70858884
Obstructive airways disorder 12.07 12.06 5 68271 26108 70834060
Laryngeal oedema 12.06 12.06 24 68252 7471 70852697

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BB02 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB52 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB72 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D058633 Antipyretics
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:49110 peripheral nervous system drugs
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:73263 cyclooxygenase-3 inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Zimeta Kindred Biosciences Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.21 acidic
pKa2 5.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Transient receptor potential cation channel subfamily A member 1 Ion channel BLOCKER IC50 4.04 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D08190 KEGG_DRUG
N0000167060 NUI
50567-35-6 SECONDARY_CAS_RN
CHEBI:59033 CHEBI
CHEMBL3989803 ChEMBL_ID
C024864 MESH_SUPPLEMENTAL_RECORD_UI
10608 IUPHAR_LIGAND_ID
5907-38-0 SECONDARY_CAS_RN
DB04817 DRUGBANK_ID
934T64RMNJ UNII
1537943 RXNORM
NOCODE MMSL
001609 NDDF
006029 NDDF
22165008 SNOMEDCT_US
735071007 SNOMEDCT_US
780831000 SNOMEDCT_US
781025005 SNOMEDCT_US
C0012586 UMLSCUI
D004177 MESH_DESCRIPTOR_UI
CHEMBL461522 ChEMBL_ID
477 INN_ID
3111 PUBCHEM_CID
6150-97-6 SECONDARY_CAS_RN
51996-59-9 SECONDARY_CAS_RN

Pharmaceutical products:

None