All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

metamizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory analgesics, phenylbutazone derivatives	4659	68-89-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: algocalmin metamizole metamizole sodium metamizol metapyrin methampyrone dipyrone dipyrone monohydrate sulpyrine metamizole magnesium metamizole calcium	A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Molecular weight: 311.36 Formula: C13H17N3O4S CLOGP: -1.20 LIPINSKI: 0 HAC: 7 HDO: 1 TPSA: 81.16 ALOGS: -2.09 ROTB: 4

Drug dosage:

Dose	Unit	Route
3	g	O
3	g	P
3	g	R

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1349.59	12.44	1078	41667	168932	56080390
Product prescribing error	569.20	12.44	300	42445	22886	56226436
Haematochezia	317.22	12.44	264	42481	43454	56205868
Agranulocytosis	283.89	12.44	190	42555	22469	56226853
Anaemia	274.77	12.44	618	42127	266893	55982429
Product monitoring error	273.99	12.44	102	42643	3357	56245965
Systemic infection	246.56	12.44	93	42652	3176	56246146
Drug ineffective	220.81	12.44	225	42520	918764	55330558
Fracture	192.50	12.44	137	42608	17881	56231441
Haematemesis	149.63	12.44	144	42601	28614	56220708
Polyneuropathy	148.16	12.44	103	42642	12947	56236375
Rheumatoid arthritis	141.34	12.44	57	42688	382547	55866775
Joint swelling	141.13	12.44	25	42720	289775	55959547
Fall	136.77	12.44	585	42160	356925	55892397
Aspirin-exacerbated respiratory disease	131.81	12.44	42	42703	855	56248467
Labelled drug-drug interaction medication error	125.83	12.44	89	42656	11497	56237825
Product dose omission issue	112.98	12.44	12	42733	204741	56044581
Systemic lupus erythematosus	112.18	12.44	6	42739	180072	56069250
Abdominal discomfort	111.32	12.44	36	42709	277238	55972084
Leukopenia	111.26	12.44	196	42549	70744	56178578
Infusion related reaction	106.18	12.44	16	42729	208915	56040407
Synovitis	104.96	12.44	4	42741	161301	56088021
Abdominal pain lower	104.15	12.44	107	42638	22985	56226337
Pemphigus	101.95	12.44	4	42741	157208	56092114
Treatment failure	99.29	12.44	8	42737	170384	56078938
Pallor	96.65	12.44	105	42640	24044	56225278
Restlessness	90.06	12.44	106	42639	26480	56222842
Therapeutic product effect decreased	88.36	12.44	12	42733	169440	56079882
Toxic epidermal necrolysis	86.75	12.44	95	42650	21947	56227375
Dyspnoea	84.73	12.44	751	41994	591826	55657496
Erysipelas	84.38	12.44	58	42687	7155	56242167
Arthropathy	83.96	12.44	24	42721	200251	56049071
Apathy	83.83	12.44	60	42685	7894	56241428
Abdominal pain	83.44	12.44	403	42342	258402	55990920
Swelling	83.22	12.44	39	42706	239732	56009590
Drug intolerance	83.18	12.44	49	42696	264769	55984553
Vomiting	81.54	12.44	651	42094	497577	55751745
Product administration error	80.28	12.44	89	42656	20840	56228482
Stevens-Johnson syndrome	77.83	12.44	91	42654	22572	56226750
Sinusitis	76.90	12.44	27	42718	197554	56051768
Arrhythmia	75.57	12.44	112	42633	34971	56214351
Nausea	74.28	12.44	895	41850	763283	55486039
Alopecia	70.90	12.44	71	42674	293387	55955935
Abdominal pain upper	70.43	12.44	295	42450	178018	56071304
Tachypnoea	65.10	12.44	69	42676	15361	56233961
Pancytopenia	64.42	12.44	180	42565	88535	56160787
Malaise	64.39	12.44	113	42632	367747	55881575
Drug-induced liver injury	64.37	12.44	103	42642	34359	56214963
Drug hypersensitivity	63.75	12.44	69	42676	275136	55974186
Jaundice	61.48	12.44	89	42656	27205	56222117
Pericarditis	61.04	12.44	6	42739	108917	56140405
Renal impairment	60.82	12.44	166	42579	80547	56168775
Electrolyte imbalance	59.58	12.44	71	42674	17962	56231360
Haematoma	58.84	12.44	95	42650	31924	56217398
Lower respiratory tract infection	57.80	12.44	9	42736	114785	56134537
Upper gastrointestinal haemorrhage	57.76	12.44	68	42677	16986	56232336
Product use issue	56.18	12.44	36	42709	186005	56063317
Acute hepatic failure	55.98	12.44	66	42679	16512	56232810
Maternal exposure during pregnancy	55.46	12.44	38	42707	189515	56059807
Completed suicide	54.31	12.44	17	42728	133816	56115506
Cardiac failure	54.22	12.44	161	42584	81932	56167390
Musculoskeletal stiffness	53.13	12.44	26	42719	155981	56093341
Gamma-glutamyltransferase increased	52.95	12.44	89	42656	30916	56218406
Ascites	52.81	12.44	99	42646	37445	56211877
Tachycardia	52.23	12.44	188	42557	105688	56143634
Drug interaction	50.73	12.44	302	42443	209453	56039869
Oedema peripheral	50.38	12.44	260	42485	170994	56078328
Haemorrhagic erosive gastritis	47.23	12.44	15	42730	302	56249020
Dysuria	46.97	12.44	84	42661	30645	56218677
Osteochondrosis	46.56	12.44	21	42724	1135	56248187
Contraindicated product administered	46.18	12.44	44	42701	186242	56063080
Therapeutic drug monitoring analysis not performed	46.09	12.44	20	42725	985	56248337
Hypokalaemia	45.99	12.44	167	42578	94270	56155052
Malignant neoplasm progression	45.47	12.44	141	42604	73446	56175876
Gastritis erosive	45.29	12.44	36	42709	5541	56243781
Disturbance in attention	44.77	12.44	85	42660	32455	56216867
Pyrexia	44.67	12.44	500	42245	418273	55831049
Atrial fibrillation	43.60	12.44	181	42564	108716	56140606
Arthralgia	43.28	12.44	215	42530	501454	55747868
Nasopharyngitis	43.20	12.44	63	42682	220896	56028426
Dehydration	43.19	12.44	236	42509	158589	56090733
Nasal disorder	43.17	12.44	26	42719	2556	56246766
Listless	42.71	12.44	26	42719	2606	56246716
Syncope	41.88	12.44	178	42567	108021	56141301
Concomitant disease aggravated	41.57	12.44	41	42704	8385	56240937
Tumour pain	41.30	12.44	20	42725	1271	56248051
Helicobacter infection	41.14	12.44	4	42741	73264	56176058
Hepatorenal failure	40.71	12.44	16	42729	611	56248711
Discomfort	40.68	12.44	29	42716	141732	56107590
Stenosis	40.67	12.44	20	42725	1314	56248008
Reduced facial expression	40.55	12.44	22	42723	1774	56247548
Acute kidney injury	39.96	12.44	316	42429	240447	56008875
Injection site pain	39.15	12.44	20	42725	117098	56132224
Medication error	39.05	12.44	94	42651	42241	56207081
Psoriasis	39.01	12.44	11	42734	92681	56156641
Weight increased	38.84	12.44	72	42673	229631	56019691
Cardiac failure congestive	37.68	12.44	10	42735	87710	56161612
Subileus	37.60	12.44	25	42720	2919	56246403
Product used for unknown indication	37.32	12.44	16	42729	765	56248557
Dizziness	36.91	12.44	442	42303	375698	55873624
Thrombocytopenia	36.75	12.44	202	42543	136022	56113300
Rash	36.64	12.44	222	42523	492825	55756497
Cachexia	36.12	12.44	30	42715	4912	56244410
Suspected product quality issue	35.63	12.44	11	42734	201	56249121
Pelvic fracture	35.37	12.44	45	42700	12168	56237154
Hepatitis toxic	35.15	12.44	24	42721	2928	56246394
Musculoskeletal pain	34.95	12.44	138	42607	81014	56168308
Gallbladder polyp	34.89	12.44	15	42730	722	56248600
Somatic symptom disorder	34.78	12.44	21	42724	2074	56247248
Urogenital haemorrhage	33.67	12.44	11	42734	243	56249079
Constipation	33.46	12.44	265	42480	201678	56047644
Prescription drug used without a prescription	33.27	12.44	20	42725	1960	56247362
Spinal pain	33.17	12.44	43	42702	11841	56237481
Facial nerve disorder	32.00	12.44	13	42732	542	56248780
Headache	31.71	12.44	272	42473	558772	55690550
Type I hypersensitivity	31.55	12.44	21	42724	2457	56246865
Therapeutic product effect incomplete	31.33	12.44	21	42724	106010	56143312
Angina pectoris	31.23	12.44	67	42678	27909	56221413
Hypersensitivity	30.93	12.44	96	42649	256312	55993010
Ileus	30.87	12.44	45	42700	13837	56235485
Delirium	30.58	12.44	86	42659	42431	56206891
Gastrointestinal sounds abnormal	29.70	12.44	24	42721	3781	56245541
Bicytopenia	29.41	12.44	19	42726	2114	56247208
Nasal congestion	29.34	12.44	4	42741	56366	56192956
Diverticulum intestinal	29.32	12.44	30	42715	6410	56242912
Faecaloma	29.15	12.44	32	42713	7409	56241913
Psychotic symptom	28.78	12.44	16	42729	1353	56247969
Off label use	28.75	12.44	277	42468	555903	55693419
Respiratory alkalosis	28.63	12.44	20	42725	2531	56246791
Hyponatraemia	28.57	12.44	153	42592	101986	56147336
Therapy non-responder	28.31	12.44	6	42739	61349	56187973
Hospitalisation	27.89	12.44	11	42734	74989	56174333
Injection site erythema	27.76	12.44	12	42733	77436	56171886
Thirst	27.69	12.44	38	42707	11052	56238270
Chromaturia	27.51	12.44	45	42700	15280	56234042
Mucosal haemorrhage	27.46	12.44	14	42731	994	56248328
Psoriatic arthropathy	27.28	12.44	11	42734	73997	56175325
Muscle tone disorder	27.20	12.44	8	42737	123	56249199
Nail toxicity	26.66	12.44	10	42735	336	56248986
Gastrointestinal disorder	26.34	12.44	28	42717	112674	56136648
Hypoaesthesia	26.04	12.44	42	42703	141449	56107873
Post-traumatic pain	25.74	12.44	10	42735	370	56248952
Immobile	25.72	12.44	26	42719	5476	56243846
Vascular encephalopathy	25.39	12.44	10	42735	384	56248938
Hepatic failure	25.33	12.44	69	42676	33417	56215905
Thirst decreased	25.31	12.44	9	42736	259	56249063
Heart rate increased	25.27	12.44	16	42729	83257	56166065
Antineutrophil cytoplasmic antibody positive	25.25	12.44	11	42734	547	56248775
Feeling abnormal	25.21	12.44	39	42706	133563	56115759
Insomnia	25.19	12.44	69	42676	191791	56057531
Blood pressure increased	24.97	12.44	45	42700	145131	56104191
Acute generalised exanthematous pustulosis	24.92	12.44	34	42711	9835	56239487
Hepatic enzyme increased	24.53	12.44	59	42686	171325	56077997
Pseudarthrosis	24.17	12.44	10	42735	437	56248885
Gastric mucosa erythema	24.03	12.44	9	42736	301	56249021
Gastric ulcer	24	12.44	53	42692	22510	56226812
Injury	23.57	12.44	8	42737	59843	56189479
Drug reaction with eosinophilia and systemic symptoms	23.48	12.44	63	42682	30241	56219081
Urinary retention	23.42	12.44	60	42685	28014	56221308
Pleural effusion	23.20	12.44	127	42618	85353	56163969
Injection site reaction	23.00	12.44	6	42739	53241	56196081
Hepatitis acute	22.95	12.44	30	42715	8327	56240995
Therapeutic response decreased	22.68	12.44	6	42739	52752	56196570
Death	22.64	12.44	159	42586	341267	55908055
Device stimulation issue	22.58	12.44	6	42739	62	56249260
Head discomfort	22.55	12.44	36	42709	11978	56237344
Lividity	22.31	12.44	8	42737	236	56249086
Peripheral swelling	22.30	12.44	97	42648	234629	56014693
Gastroenteritis	22.29	12.44	54	42691	24358	56224964
Circulatory collapse	22.28	12.44	49	42696	20754	56228568
Localised infection	22.27	12.44	58	42687	27354	56221968
Foreign body	22.25	12.44	16	42729	2120	56247202
Suspected product contamination	21.98	12.44	5	42740	25	56249297
Dyspnoea exertional	21.95	12.44	91	42654	54598	56194724
Lethargy	21.83	12.44	6	42739	51435	56197887
Vasculitis	21.79	12.44	40	42705	14883	56234439
Myocardial infarction	21.78	12.44	23	42722	92847	56156475
Injection site pruritus	21.76	12.44	3	42742	41928	56207394
Bradycardia	21.59	12.44	105	42640	67399	56181923
Hepatic cyst	21.23	12.44	22	42723	4771	56244551
Paresis	21.20	12.44	16	42729	2282	56247040
Oliguria	21.19	12.44	29	42716	8411	56240911
Hyperkinesia	21.13	12.44	14	42731	1625	56247697
Adverse event	20.79	12.44	8	42737	55368	56193954
Aortic valve stenosis	20.74	12.44	18	42727	3129	56246193
Spontaneous haemorrhage	20.67	12.44	8	42737	293	56249029
Vertigo	20.50	12.44	89	42656	54483	56194839
Pain in jaw	20.46	12.44	3	42742	40033	56209289
Amnesia	20.43	12.44	5	42740	46317	56203005
Paranasal sinus inflammation	20.41	12.44	9	42736	461	56248861
Liver function test increased	20.32	12.44	57	42688	28076	56221246
Coombs negative haemolytic anaemia	20.14	12.44	7	42738	188	56249134
Fluid intake reduced	20.06	12.44	18	42727	3269	56246053
Acute abdomen	19.98	12.44	13	42732	1463	56247859
Urosepsis	19.78	12.44	41	42704	16675	56232647
Medication overuse headache	19.73	12.44	10	42735	701	56248621
Ill-defined disorder	19.68	12.44	14	42731	68529	56180793
Irritable bowel syndrome	19.63	12.44	14	42731	68444	56180878
Transaminases increased	19.53	12.44	57	42688	28713	56220609
Neuropathy peripheral	19.44	12.44	30	42715	102863	56146459
Unevaluable event	19.44	12.44	6	42739	47681	56201641
Cholestatic liver injury	19.29	12.44	15	42730	2237	56247085
Pneumobilia	19.07	12.44	6	42739	117	56249205
Decreased appetite	19.04	12.44	252	42493	218979	56030343
Hypertensive emergency	18.93	12.44	13	42732	1600	56247722
Peritoneal perforation	18.93	12.44	6	42739	120	56249202
Left ventricular hypertrophy	18.77	12.44	21	42724	4963	56244359
Necrotising fasciitis	18.70	12.44	16	42729	2729	56246593
Duodenal ulcer	18.60	12.44	25	42720	7130	56242192
Heart rate decreased	18.56	12.44	4	42741	40423	56208899
Febrile infection	18.32	12.44	12	42733	1366	56247956
Gastritis	18.28	12.44	63	42682	34639	56214683
Chills	18.28	12.44	137	42608	102467	56146855
Spinal osteoarthritis	18.27	12.44	37	42708	14799	56234523
Stoma site inflammation	18.12	12.44	8	42737	411	56248911
Sensory level abnormal	18.10	12.44	6	42739	139	56249183
Inappropriate schedule of product administration	18.08	12.44	22	42723	83365	56165957
Intentional product use issue	17.98	12.44	30	42715	99703	56149619
No adverse event	17.97	12.44	3	42742	36371	56212951
Nail avulsion	17.90	12.44	6	42739	144	56249178
Haematuria	17.87	12.44	53	42692	26934	56222388
Disease progression	17.72	12.44	33	42712	105140	56144182
Sensory disturbance	17.54	12.44	33	42712	12510	56236812
Depressed level of consciousness	17.48	12.44	87	42658	56346	56192976
Metastatic malignant melanoma	17.47	12.44	12	42733	1478	56247844
Peripheral circulatory failure	17.38	12.44	10	42735	903	56248419
Patent ductus arteriosus	17.25	12.44	18	42727	3933	56245389
Loss of personal independence in daily activities	17.09	12.44	22	42723	81347	56167975
Cellulitis	17.09	12.44	19	42726	74930	56174392
Faeces pale	16.92	12.44	12	42733	1555	56247767
Affective disorder	16.79	12.44	21	42724	5582	56243740
Anaemia folate deficiency	16.36	12.44	6	42739	189	56249133
Urogenital infection bacterial	16.20	12.44	4	42741	30	56249292
Internal haemorrhage	16.14	12.44	19	42726	4745	56244577
Electrocardiogram abnormal	16.11	12.44	25	42720	8119	56241203
Dyschezia	16.08	12.44	13	42732	2050	56247272
Leukocytosis	16.01	12.44	47	42698	23744	56225578
Neutropenia	15.95	12.44	187	42558	157980	56091342
Brain contusion	15.94	12.44	8	42737	549	56248773
Peripheral arterial occlusive disease	15.85	12.44	17	42728	3833	56245489
Painful respiration	15.81	12.44	14	42731	2500	56246822
Merycism	15.76	12.44	6	42739	210	56249112
Hyperaemia	15.76	12.44	13	42732	2109	56247213
Migraine	15.74	12.44	26	42719	86771	56162551
Pregnancy	15.72	12.44	3	42742	33030	56216292
C-reactive protein increased	15.71	12.44	108	42637	78576	56170746
Type 2 diabetes mellitus	15.65	12.44	8	42737	46854	56202468
Knee arthroplasty	15.63	12.44	7	42738	44252	56205070
Flank pain	15.63	12.44	34	42711	14291	56235031
Hyperglycaemia	15.59	12.44	64	42681	38217	56211105
Contusion	15.53	12.44	48	42697	128382	56120940
Lumbar vertebral fracture	15.51	12.44	19	42726	4945	56244377
Pulmonary vein occlusion	15.50	12.44	5	42740	106	56249216
Conjunctivitis	15.48	12.44	39	42706	18021	56231301
Arthritis	15.39	12.44	33	42712	99819	56149503
Urinary tract infection enterococcal	15.36	12.44	14	42731	2595	56246727
VIIIth nerve injury	15.26	12.44	3	42742	6	56249316
Cardiac murmur functional	15.17	12.44	4	42741	40	56249282
Abdominal wall cyst	15.00	12.44	4	42741	42	56249280
Bulimia nervosa	14.88	12.44	7	42738	417	56248905
Kyphosis	14.83	12.44	13	42732	2289	56247033
Reticulocyte count increased	14.63	12.44	9	42736	919	56248403
Prerenal failure	14.61	12.44	11	42734	1564	56247758
Hepatitis cholestatic	14.56	12.44	21	42724	6393	56242929
Exposure during pregnancy	14.41	12.44	54	42691	136288	56113034
Necrolytic migratory erythema	14.40	12.44	3	42742	9	56249313
Angioedema	14.36	12.44	66	42679	41387	56207935
Dysphagia	14.35	12.44	109	42636	81838	56167484
Adverse drug reaction	14.32	12.44	17	42728	65115	56184207
Petechiae	14.29	12.44	31	42714	13008	56236314
Coronavirus test positive	14.28	12.44	8	42737	687	56248635
Myoclonus	14.28	12.44	34	42711	15169	56234153
Shock haemorrhagic	14.20	12.44	25	42720	9008	56240314
Lordosis	14.17	12.44	6	42739	278	56249044
Autoimmune colitis	13.93	12.44	7	42738	482	56248840
Gastrointestinal infection	13.93	12.44	23	42722	7871	56241451
Mucosal dryness	13.92	12.44	13	42732	2485	56246837
Cardio-respiratory arrest	13.77	12.44	13	42732	55308	56194014
Metastatic gastric cancer	13.77	12.44	5	42740	153	56249169
Sinobronchitis	13.68	12.44	5	42740	156	56249166
Bone marrow oedema	13.58	12.44	9	42736	1045	56248277
Cerebrovascular accident	13.55	12.44	35	42710	99235	56150087
CD8 lymphocytes decreased	13.50	12.44	5	42740	162	56249160
Chronic fatigue syndrome	13.50	12.44	9	42736	1056	56248266
Surgery	13.40	12.44	4	42741	32482	56216840
Fatigue	13.27	12.44	478	42267	788074	55461248
Upper respiratory tract infection	13.26	12.44	21	42724	71267	56178055
Hyperresponsive to stimuli	13.23	12.44	4	42741	68	56249254
Gastrointestinal tract adenoma	13.17	12.44	6	42739	332	56248990
Systemic inflammatory response syndrome	13.05	12.44	18	42727	5260	56244062
Ileus paralytic	13.01	12.44	16	42729	4179	56245143
Rheumatic fever	12.93	12.44	3	42742	28824	56220498
Unresponsive to stimuli	12.91	12.44	4	42741	31721	56217601
Piloerection	12.79	12.44	6	42739	355	56248967
Cancer fatigue	12.76	12.44	4	42741	77	56249245
Gastric ulcer perforation	12.65	12.44	9	42736	1172	56248150
Peripheral nerve lesion	12.65	12.44	6	42739	364	56248958
Ileal stenosis	12.60	12.44	10	42735	1535	56247787
Normochromic normocytic anaemia	12.55	12.44	16	42729	4333	56244989
Substance dependence	12.53	12.44	5	42740	199	56249123
Acute myocardial infarction	12.53	12.44	51	42694	30342	56218980
Flatulence	12.50	12.44	52	42693	31236	56218086
Dysplasia	12.50	12.44	8	42737	876	56248446

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1353.51	13.84	1041	32041	112394	31551868
Product prescribing error	342.39	13.84	228	32854	19414	31644848
Systemic infection	209.89	13.84	92	32990	3357	31660905
Haematochezia	174.33	13.84	213	32869	40251	31624011
Anaemia	156.99	13.84	534	32548	212988	31451274
Product monitoring error	156.72	13.84	74	33008	3216	31661046
Drug ineffective	152.22	13.84	115	32967	395458	31268804
Abdominal pain	114.11	13.84	373	32709	145579	31518683
Death	95.78	13.84	143	32939	360426	31303836
Musculoskeletal pain	91.42	13.84	133	32949	29695	31634567
Appendicolith	91.36	13.84	63	33019	5668	31658594
Agranulocytosis	86.86	13.84	109	32973	21138	31643124
Completed suicide	82.26	13.84	3	33079	91511	31572751
Abdominal pain upper	77.75	13.84	192	32890	63810	31600452
Pallor	76.12	13.84	105	32977	22319	31641943
Vomiting	74.63	13.84	443	32639	223530	31440732
Leukopenia	74.00	13.84	177	32905	57651	31606611
Nausea	68.77	13.84	552	32530	307395	31356867
Cardiac failure congestive	66.83	13.84	4	33078	79383	31584879
Labelled drug-drug interaction medication error	66.09	13.84	75	33007	13088	31651174
Appendicitis	65.67	13.84	70	33012	11395	31652867
Malaise	64.50	13.84	49	33033	168462	31495800
Tachypnoea	61.76	13.84	81	33001	16402	31647860
Product dose omission issue	61.56	13.84	17	33065	105569	31558693
Micturition disorder	59.10	13.84	33	33049	2040	31662222
Fracture	56.16	13.84	49	33033	6231	31658031
Electrolyte imbalance	55.60	13.84	66	33016	12082	31652180
Acute abdomen	55.00	13.84	30	33052	1771	31662491
Tachycardia	53.44	13.84	188	32894	76019	31588243
Constipation	52.48	13.84	262	32820	123729	31540533
Dyspnoea	51.64	13.84	566	32516	342913	31321349
Neuropathy peripheral	44.41	13.84	12	33070	75637	31588625
Paresis	44.38	13.84	27	33055	1960	31662302
Negative pressure pulmonary oedema	43.59	13.84	14	33068	209	31664053
Dyschezia	43.55	13.84	23	33059	1272	31662990
Blood pressure measurement	42.41	13.84	13	33069	165	31664097
Electrocardiogram abnormal	40.70	13.84	46	33036	7990	31656272
Restlessness	40.68	13.84	81	33001	23280	31640982
Neuromuscular block prolonged	40.49	13.84	16	33066	447	31663815
Pyrexia	39.92	13.84	488	32594	303352	31360910
Polyneuropathy	39.78	13.84	58	33024	12964	31651298
Myocardial infarction	39.65	13.84	36	33046	113418	31550844
Hyponatraemia	38.61	13.84	166	32916	73633	31590629
Toxicity to various agents	38.10	13.84	83	32999	181404	31482858
Oedema peripheral	37.56	13.84	219	32863	109620	31554642
Mucosal haemorrhage	36.97	13.84	22	33060	1534	31662728
Disturbance in attention	36.90	13.84	76	33006	22374	31641888
C-reactive protein increased	36.68	13.84	123	32959	48527	31615735
Abdominal distension	36.34	13.84	126	32956	50558	31613704
Blood phosphorus increased	36.16	13.84	33	33049	4449	31659813
Therapeutic drug monitoring analysis not performed	35.62	13.84	15	33067	495	31663767
Cachexia	35.14	13.84	39	33043	6640	31657622
Malignant neoplasm progression	34.86	13.84	169	32913	78829	31585433
Impaired healing	34.83	13.84	57	33025	14075	31650187
Platelet dysfunction	34.39	13.84	12	33070	234	31664028
Product administration error	34.26	13.84	59	33023	15188	31649074
Fall	33.75	13.84	319	32763	185770	31478492
Interstitial lung disease	33.74	13.84	11	33071	61392	31602870
Gamma-glutamyltransferase increased	33.25	13.84	83	32999	27742	31636520
Hospitalisation	33.06	13.84	6	33076	49801	31614461
Ventricular fibrillation	32.39	13.84	65	33017	18783	31645479
Treatment failure	31.64	13.84	3	33079	40789	31623473
Medication error	31.61	13.84	72	33010	22700	31641562
Platelet count decreased	30.94	13.84	42	33040	110393	31553869
Drug abuse	30.47	13.84	28	33054	87730	31576532
Stress	30.43	13.84	75	33007	24866	31639396
Wound	30.33	13.84	51	33031	12877	31651385
Cardiogenic shock	30.16	13.84	70	33012	22338	31641924
Hypertensive crisis	30.07	13.84	40	33042	8207	31656055
Weight bearing difficulty	29.45	13.84	16	33066	937	31663325
Respiratory tract haemorrhage	29.25	13.84	17	33065	1134	31663128
Leptotrichia infection	28.29	13.84	8	33074	75	31664187
Drug reaction with eosinophilia and systemic symptoms	28.27	13.84	82	33000	29936	31634326
Blood pressure increased	28.13	13.84	25	33057	79608	31584654
Internal fixation of fracture	27.57	13.84	8	33074	83	31664179
Infusion related reaction	27.50	13.84	8	33074	48047	31616215
Accessory spleen	27.45	13.84	9	33073	144	31664118
Toxic epidermal necrolysis	27.39	13.84	62	33020	19462	31644800
Ascites	26.86	13.84	99	32983	40914	31623348
Feeling abnormal	26.75	13.84	13	33069	56989	31607273
Erysipelas	26.63	13.84	28	33054	4485	31659777
Dizziness	26.56	13.84	321	32761	198826	31465436
Haematemesis	26.03	13.84	72	33010	25581	31638681
Cardiac arrest	25.83	13.84	33	33049	89029	31575233
Gastrointestinal adenocarcinoma	25.63	13.84	7	33075	57	31664205
Disease progression	24.74	13.84	35	33047	90429	31573833
Suspected product contamination	24.63	13.84	7	33075	67	31664195
Hydrocholecystis	24.30	13.84	10	33072	311	31663951
Hyperventilation	23.34	13.84	20	33062	2481	31661781
Urosepsis	23.30	13.84	43	33039	11677	31652585
Multiple organ dysfunction syndrome	23.29	13.84	136	32946	68067	31596195
Thrombosis	23.25	13.84	9	33073	45142	31619120
Iris adhesions	23.20	13.84	9	33073	239	31664023
Pain	23.16	13.84	297	32785	186462	31477800
Condition aggravated	23.01	13.84	267	32815	163742	31500520
Psoriasis	22.94	13.84	10	33072	46709	31617553
Therapeutic product effect decreased	22.82	13.84	3	33079	31619	31632643
Haematoma	22.78	13.84	66	33016	24073	31640189
Cold sweat	22.50	13.84	37	33045	9172	31655090
Joint swelling	22.44	13.84	14	33068	53417	31610845
Long QT syndrome	22.31	13.84	19	33063	2337	31661925
Hepatorenal failure	22.17	13.84	11	33071	533	31663729
Depressed level of consciousness	21.87	13.84	89	32993	38512	31625750
Implant site inflammation	21.76	13.84	7	33075	105	31664157
Tension headache	21.29	13.84	15	33067	1396	31662866
Abdominal discomfort	20.99	13.84	14	33068	51553	31612709
Adenocarcinoma of appendix	20.96	13.84	7	33075	119	31664143
Intestinal haemorrhage	20.57	13.84	21	33061	3250	31661012
Contraindicated product administered	20.56	13.84	56	33026	19716	31644546
Therapy non-responder	20.53	13.84	5	33077	33806	31630456
Angioedema	20.23	13.84	79	33003	33539	31630723
Cardiovascular insufficiency	20.17	13.84	15	33067	1519	31662743
Labelled drug-drug interaction issue	20.16	13.84	8	33074	226	31664036
Pseudarthrosis	19.73	13.84	6	33076	74	31664188
Product prescribing issue	19.68	13.84	15	33067	1576	31662686
Osteochondrosis	19.57	13.84	12	33070	883	31663379
Suspected product quality issue	19.45	13.84	7	33075	150	31664112
Thirst	19.33	13.84	29	33053	6647	31657615
Tracheal atresia	19.08	13.84	4	33078	8	31664254
Mineral supplementation	19.04	13.84	6	33076	84	31664178
Lack of application site rotation	18.76	13.84	4	33078	9	31664253
Spinal pain	18.64	13.84	25	33057	5170	31659092
Pulmonary sepsis	18.59	13.84	16	33066	1996	31662266
Coma	18.39	13.84	10	33072	41140	31623122
Immobile	18.31	13.84	17	33065	2343	31661919
Febrile infection	18.25	13.84	16	33066	2046	31662216
Genitourinary tract infection	18.18	13.84	6	33076	98	31664164
Chronic fatigue syndrome	18.09	13.84	8	33074	298	31663964
Hepatic cyst	18.08	13.84	17	33065	2381	31661881
Dysdiadochokinesis	17.83	13.84	7	33075	192	31664070
Platelet function test abnormal	17.75	13.84	6	33076	106	31664156
Unevaluable event	17.65	13.84	5	33077	30570	31633692
Heart rate decreased	17.52	13.84	4	33078	28262	31636000
Unresponsive to stimuli	17.35	13.84	3	33079	25797	31638465
Flushing	17.26	13.84	5	33077	30123	31634139
Adrenocortical insufficiency acute	17.25	13.84	13	33069	1343	31662919
Autoimmune nephritis	17.21	13.84	7	33075	211	31664051
Musculoskeletal stiffness	17.12	13.84	11	33071	41314	31622948
Vertigo	17.06	13.84	58	33024	23027	31641235
Gastritis haemorrhagic	17.00	13.84	13	33069	1372	31662890
Toxic neuropathy	16.97	13.84	9	33073	502	31663760
Flank pain	16.93	13.84	26	33056	6083	31658179
Urogenital infection bacterial	16.88	13.84	5	33077	56	31664206
Cardiac disorder	16.85	13.84	10	33072	39204	31625058
Anxiety disorder	16.73	13.84	14	33068	1681	31662581
Reflux nephropathy	16.65	13.84	5	33077	59	31664203
Drug intolerance	16.45	13.84	18	33064	52015	31612247
Tonsillitis	16.11	13.84	15	33067	2075	31662187
Blood folate increased	16.08	13.84	7	33075	251	31664011
Paraparesis	15.96	13.84	14	33068	1792	31662470
Spinal cord injury cauda equina	15.96	13.84	6	33076	146	31664116
White blood cell count decreased	15.91	13.84	43	33039	87355	31576907
Orthostatic hypotension	15.80	13.84	3	33079	24116	31640146
Lung disorder	15.73	13.84	7	33075	32305	31631957
Jaundice	15.72	13.84	68	33014	30219	31634043
Cardiovascular disorder	15.70	13.84	32	33050	9346	31654916
Somatosensory evoked potentials abnormal	15.66	13.84	6	33076	154	31664108
Loss of personal independence in daily activities	15.65	13.84	5	33077	28283	31635979
Influenza	15.54	13.84	14	33068	44311	31619951
Breath sounds normal	15.52	13.84	3	33079	3	31664259
Swelling	15.40	13.84	10	33072	37348	31626914
Cerebrovascular accident	15.32	13.84	38	33044	79446	31584816
Thrombocytopenia	15.21	13.84	221	32861	142526	31521736
Drug resistance	15.19	13.84	3	33079	23450	31640812
Disorientation	15.18	13.84	68	33014	30676	31633586
Nail bed inflammation	15.14	13.84	6	33076	169	31664093
Haemorrhagic necrotic pancreatitis	15.10	13.84	6	33076	170	31664092
Lower gastrointestinal haemorrhage	14.97	13.84	30	33052	8659	31655603
Anxiety	14.97	13.84	47	33035	90986	31573276
Fear of disease	14.93	13.84	7	33075	299	31663963
Oedematous pancreatitis	14.86	13.84	8	33074	460	31663802
Coronavirus test positive	14.75	13.84	8	33074	467	31663795
Vitamin B6 deficiency	14.69	13.84	6	33076	183	31664079
Rectal haemorrhage	14.58	13.84	10	33072	36294	31627968
Food interaction	14.52	13.84	10	33072	897	31663365
Mycobacterium fortuitum infection	14.48	13.84	6	33076	190	31664072
Product packaging confusion	14.39	13.84	4	33078	35	31664227
Upper gastrointestinal haemorrhage	14.37	13.84	55	33027	23128	31641134
Primary biliary cholangitis	14.27	13.84	6	33076	197	31664065
Autoimmune hepatitis	14.27	13.84	19	33063	3901	31660361
Fear of falling	14.27	13.84	7	33075	331	31663931
Anal haemorrhage	14.26	13.84	15	33067	2403	31661859
Preternatural anus	14.21	13.84	5	33077	100	31664162
Psychotic disorder	14.13	13.84	3	33079	22290	31641972
Renal impairment	14.13	13.84	145	32937	86204	31578058
Therapeutic response decreased	14.12	13.84	5	33077	26504	31637758
Seizure	14.06	13.84	55	33027	99713	31564549
Target skin lesion	13.99	13.84	3	33079	7	31664255
Respiratory arrest	13.91	13.84	5	33077	26252	31638010
Oral herpes	13.87	13.84	21	33061	4852	31659410

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	2666.88	12.06	2030	66246	234001	70626167
Product prescribing error	883.97	12.06	519	67757	38433	70821735
Haematochezia	480.90	12.06	463	67813	72618	70787550
Systemic infection	443.76	12.06	185	68091	6472	70853696
Anaemia	436.34	12.06	1099	67177	402324	70457844
Product monitoring error	410.69	12.06	176	68100	6600	70853568
Agranulocytosis	304.77	12.06	276	68000	40022	70820146
Drug ineffective	271.77	12.06	304	67972	939448	69920720
Fracture	235.56	12.06	177	68099	19767	70840401
Labelled drug-drug interaction medication error	179.93	12.06	164	68112	23963	70836205
Pallor	174.17	12.06	206	68070	40768	70819400
Abdominal pain	171.27	12.06	717	67559	341410	70518758
Leukopenia	156.22	12.06	328	67948	106232	70753936
Haematemesis	156.17	12.06	213	68063	48584	70811584
Completed suicide	153.52	12.06	19	68257	227116	70633052
Vomiting	149.64	12.06	1029	67247	592082	70268086
Joint swelling	143.09	12.06	34	68242	253177	70606991
Nausea	140.47	12.06	1341	66935	850747	70009421
Abdominal pain upper	138.93	12.06	456	67820	193146	70667022
Fall	137.54	12.06	812	67464	443284	70416884
Aspirin-exacerbated respiratory disease	135.21	12.06	49	68227	1166	70859002
Malaise	134.74	12.06	131	68145	432801	70427367
Restlessness	131.96	12.06	182	68094	41946	70818222
Dyspnoea	130.83	12.06	1220	67056	768840	70091328
Tachypnoea	130.09	12.06	149	68127	28489	70831679
Polyneuropathy	128.27	12.06	129	68147	21286	70838882
Product dose omission issue	127.28	12.06	27	68249	217441	70642727
Product administration error	119.82	12.06	145	68131	29378	70830790
Infusion related reaction	118.77	12.06	23	68253	197511	70662657
Musculoskeletal pain	118.62	12.06	266	68010	90061	70770107
Rheumatoid arthritis	116.77	12.06	68	68208	291737	70568431
Electrolyte imbalance	112.41	12.06	134	68142	26727	70833441
Abdominal discomfort	109.70	12.06	35	68241	214623	70645545
Tachycardia	103.60	12.06	362	67914	158184	70701984
Treatment failure	102.57	12.06	10	68266	144132	70716036
Synovitis	100.31	12.06	6	68270	129222	70730946
Constipation	94.31	12.06	486	67790	251952	70608216
Therapeutic product effect decreased	94.11	12.06	13	68263	143005	70717163
Appendicolith	94.05	12.06	62	68214	5618	70854550
Arthropathy	93.36	12.06	16	68260	150041	70710127
Toxic epidermal necrolysis	91.09	12.06	148	68128	39409	70820759
Cardiac failure congestive	87.52	12.06	13	68263	135444	70724724
Sinusitis	87.48	12.06	27	68249	169168	70691000
Oedema peripheral	86.48	12.06	441	67835	227650	70632518
Erysipelas	83.01	12.06	72	68204	9852	70850316
Pyrexia	82.34	12.06	919	67357	606033	70254135
Disturbance in attention	81.03	12.06	147	68129	42747	70817421
Drug intolerance	80.23	12.06	60	68216	225627	70634541
Musculoskeletal stiffness	79.28	12.06	22	68254	147738	70712430
Abdominal pain lower	78.18	12.06	115	68161	28101	70832067
Swelling	78.16	12.06	42	68234	188497	70671671
Therapeutic drug monitoring analysis not performed	77.06	12.06	35	68241	1509	70858659
Lower respiratory tract infection	74.03	12.06	10	68266	111903	70748265
Medication error	74.01	12.06	167	68109	56745	70803423
Gamma-glutamyltransferase increased	70.74	12.06	153	68123	50532	70809636
Renal impairment	70.50	12.06	300	67976	143637	70716531
Injection site pain	70.03	12.06	14	68262	117605	70742563
Jaundice	69.64	12.06	151	68125	49957	70810211
Ascites	69.43	12.06	181	68095	67366	70792802
Cachexia	69.35	12.06	65	68211	9835	70850333
Malignant neoplasm progression	68.58	12.06	265	68011	121474	70738694
Blood pressure increased	68.44	12.06	49	68227	188468	70671700
Haematoma	67.39	12.06	146	68130	48272	70811896
Pemphigus	63.99	12.06	4	68272	83032	70777136
Paresis	63.48	12.06	42	68234	3828	70856340
Dehydration	62.52	12.06	402	67874	225740	70634428
Acute abdomen	61.49	12.06	37	68239	2857	70857311
Death	61.10	12.06	268	68008	509793	70350375
Drug-induced liver injury	60.39	12.06	153	68123	55960	70804208
Osteochondrosis	60.22	12.06	30	68246	1593	70858575
Hepatorenal failure	59.10	12.06	27	68249	1180	70858988
Systemic lupus erythematosus	58.87	12.06	13	68263	101889	70758279
Electrocardiogram abnormal	57.83	12.06	71	68205	14593	70845575
Apathy	57.55	12.06	64	68212	11844	70848324
Dizziness	57.55	12.06	691	67585	463450	70396718
Suspected product quality issue	56.97	12.06	18	68258	277	70859891
Lethargy	56.89	12.06	4	68272	75246	70784922
Psoriasis	55.98	12.06	13	68263	98420	70761748
Appendicitis	54.97	12.06	74	68202	16659	70843509
Hyponatraemia	54.78	12.06	301	67975	159786	70700382
Dysuria	54.73	12.06	130	68146	45664	70814504
Nasopharyngitis	54.37	12.06	81	68195	222125	70638043
Mucosal haemorrhage	54.31	12.06	32	68244	2377	70857791
Drug hypersensitivity	53.87	12.06	107	68169	262352	70597816
Pericarditis	52.74	12.06	9	68267	84696	70775472
Abdominal distension	51.89	12.06	219	68057	104450	70755718
Dyschezia	51.75	12.06	32	68244	2595	70857573
Upper gastrointestinal haemorrhage	51.00	12.06	112	68164	37365	70822803
Myocardial infarction	50.93	12.06	54	68222	171591	70688577
Feeling abnormal	50.34	12.06	38	68238	142281	70717887
Interstitial lung disease	50.12	12.06	19	68257	104666	70755502
Acute hepatic failure	49.95	12.06	93	68183	27579	70832589
Drug reaction with eosinophilia and systemic symptoms	49.26	12.06	145	68131	57868	70802300
Mental status changes	48.74	12.06	3	68273	63098	70797070
Arthralgia	48.59	12.06	285	67991	503105	70357063
Toxicity to various agents	48.06	12.06	197	68079	381975	70478193
Alopecia	47.93	12.06	73	68203	198417	70661751
Micturition disorder	46.48	12.06	34	68242	3641	70856527
Suspected product contamination	46.12	12.06	12	68264	87	70860081
Syncope	45.41	12.06	294	67982	165415	70694753
Tumour pain	45.03	12.06	27	68249	2071	70858097
Nasal disorder	44.98	12.06	32	68244	3282	70856886
Maternal exposure during pregnancy	44.51	12.06	28	68248	115317	70744851
Negative pressure pulmonary oedema	44.46	12.06	14	68262	213	70859955
Therapy non-responder	44.05	12.06	10	68266	76905	70783263
Subileus	43.87	12.06	38	68238	5189	70854979
Neuropathy peripheral	43.46	12.06	35	68241	126861	70733307
Thrombocytopenia	43.40	12.06	385	67891	238725	70621443
Hypokalaemia	43.09	12.06	244	68032	130944	70729224
Product use issue	42.65	12.06	67	68209	179870	70680298
Thirst	42.46	12.06	61	68215	14588	70845580
Immobile	42.37	12.06	41	68235	6453	70853715
Haemorrhagic erosive gastritis	42.21	12.06	17	68259	543	70859625
Stevens-Johnson syndrome	41.90	12.06	101	68175	35806	70824362
Pancytopenia	40.13	12.06	266	68010	150841	70709327
Gastritis erosive	40.01	12.06	49	68227	10046	70850122
Product used for unknown indication	39.99	12.06	23	68253	1633	70858535
Spinal pain	39.41	12.06	57	68219	13713	70846455
Helicobacter infection	39.21	12.06	4	68272	55652	70804516
Nasal congestion	38.70	12.06	8	68268	65664	70794504
Disease progression	38.42	12.06	57	68219	156615	70703553
Hospitalisation	37.86	12.06	16	68260	82552	70777616
Type I hypersensitivity	37.27	12.06	30	68246	3702	70856466
Cellulitis	36.83	12.06	25	68251	98903	70761265
Arrhythmia	36.45	12.06	128	68148	56015	70804153
Chills	35.54	12.06	250	68026	144536	70715632
Respiratory arrest	35.23	12.06	5	68271	53928	70806240
Platelet count decreased	34.57	12.06	75	68201	178147	70682021
Listless	34.23	12.06	28	68248	3535	70856633
Therapeutic product effect incomplete	34.13	12.06	39	68237	119843	70740325
Hypoaesthesia	33.88	12.06	60	68216	153679	70706489
Heart rate decreased	33.69	12.06	9	68267	62006	70798162
Urogenital haemorrhage	33.43	12.06	16	68260	778	70859390
Febrile infection	33.21	12.06	26	68250	3083	70857085
Multiple organ dysfunction syndrome	33.14	12.06	198	68078	108317	70751851
Heart rate increased	33.06	12.06	32	68244	106116	70754052
Haematuria	33.05	12.06	135	68141	63438	70796730
Depressed level of consciousness	33.04	12.06	169	68107	87262	70772906
Drug interaction	33.02	12.06	533	67743	380908	70479260
Bradycardia	32.86	12.06	219	68057	124396	70735772
Blood pressure measurement	32.67	12.06	13	68263	402	70859766
Gastrointestinal disorder	32.59	12.06	32	68244	105395	70754773
Faecaloma	32.48	12.06	45	68231	10406	70849762
Psoriatic arthropathy	32.29	12.06	11	68265	64760	70795408
Urogenital infection bacterial	31.85	12.06	9	68267	92	70860076
Discomfort	31.45	12.06	33	68243	105403	70754765
Rash	31.44	12.06	327	67949	510235	70349933
Hypersensitivity	31.07	12.06	115	68161	229697	70630471
Weight increased	31	12.06	124	68152	242207	70617961
Loss of personal independence in daily activities	30.89	12.06	22	68254	84888	70775280
Injection site swelling	30.67	12.06	3	68273	43154	70817014
Flank pain	30.56	12.06	58	68218	17444	70842724
Hepatitis acute	30.46	12.06	51	68225	13911	70846257
Irritable bowel syndrome	30.37	12.06	6	68270	50844	70809324
Pain in jaw	30.23	12.06	3	68273	42666	70817502
Drug abuse	30.22	12.06	60	68216	147196	70712972
Folliculitis	30.15	12.06	3	68273	42567	70817601
Off label use	30.08	12.06	519	67757	742541	70117627
Platelet dysfunction	29.72	12.06	12	68264	386	70859782
Chronic fatigue syndrome	29.58	12.06	17	68259	1205	70858963
Disorientation	29.32	12.06	122	68154	57801	70802367
Unresponsive to stimuli	29.24	12.06	7	68269	51924	70808244
Injection site erythema	29.11	12.06	17	68259	72907	70787261
Coronavirus test positive	28.85	12.06	16	68260	1059	70859109
Urosepsis	28.62	12.06	68	68208	23881	70836287
Pelvic fracture	28.49	12.06	44	68232	11217	70848951
Adverse drug reaction	28.49	12.06	8	68268	53336	70806832
Contusion	28.18	12.06	50	68226	127986	70732182
Reduced facial expression	28.04	12.06	21	68255	2331	70857837
Peripheral swelling	27.82	12.06	125	68151	236438	70623730
C-reactive protein increased	27.80	12.06	192	68084	110325	70749843
Angina pectoris	27.77	12.06	106	68170	48277	70811891
Neuromuscular block prolonged	27.40	12.06	15	68261	968	70859200
Cardio-respiratory arrest	27.33	12.06	34	68242	100643	70759525
Therapeutic response decreased	27.33	12.06	11	68265	58442	70801726
Blood phosphorus increased	27.05	12.06	33	68243	6737	70853431
Respiratory tract haemorrhage	26.88	12.06	18	68258	1674	70858494
Fluid intake reduced	26.86	12.06	30	68246	5577	70854591
Accessory spleen	26.48	12.06	9	68267	176	70859992
Blood pressure fluctuation	26.16	12.06	12	68264	59000	70801168
Facial nerve disorder	25.98	12.06	13	68263	697	70859471
Fibromyalgia	25.90	12.06	7	68269	47867	70812301
Flatulence	25.61	12.06	88	68188	38093	70822075
Bicytopenia	25.47	12.06	25	68251	4003	70856165
Angioedema	25.33	12.06	129	68147	66481	70793687
Hepatic cyst	25.31	12.06	29	68247	5542	70854626
Delirium	25.30	12.06	140	68136	74474	70785694
Cardiac arrest	25.01	12.06	75	68201	159759	70700409
Gastritis haemorrhagic	24.94	12.06	20	68256	2454	70857714
Vertigo	24.30	12.06	122	68154	62521	70797647
Ventricular fibrillation	24.20	12.06	69	68207	27042	70833126
Flushing	24.19	12.06	26	68250	82146	70778022
Decreased appetite	24.19	12.06	420	67856	304360	70555808
Unevaluable event	24.01	12.06	10	68266	52053	70808115
Nail toxicity	23.97	12.06	10	68266	350	70859818
Injection site reaction	23.94	12.06	9	68267	49843	70810325
Drug resistance	23.90	12.06	4	68272	38186	70821982
Orthostatic hypotension	23.76	12.06	10	68266	51733	70808435
Cardiac disorder	23.50	12.06	14	68262	59401	70800767
Psychotic disorder	23.48	12.06	4	68272	37697	70822471
Hydrocholecystis	23.45	12.06	10	68266	370	70859798
Long QT syndrome	22.98	12.06	27	68249	5300	70854868
Ileus	22.92	12.06	63	68213	24174	70835994
Depression	22.88	12.06	106	68170	198868	70661300
Type 2 diabetes mellitus	22.83	12.06	7	68269	44073	70816095
Wound	22.78	12.06	168	68108	98564	70761604
Inappropriate schedule of product administration	22.78	12.06	43	68233	107512	70752656
Blood pressure decreased	22.71	12.06	33	68243	91482	70768686
Post-traumatic pain	22.70	12.06	10	68266	401	70859767
Cerebrovascular accident	22.68	12.06	67	68209	143403	70716765
Gallbladder polyp	22.64	12.06	13	68263	920	70859248
Thirst decreased	22.63	12.06	9	68267	278	70859890
White blood cell count decreased	22.42	12.06	86	68190	170055	70690113
Exposure during pregnancy	22.40	12.06	31	68245	87686	70772482
Migraine	22.24	12.06	22	68254	72216	70787952
Hepatitis cholestatic	22.19	12.06	42	68234	12608	70847560
Acute generalised exanthematous pustulosis	22.07	12.06	47	68229	15350	70844818
Sepsis	21.99	12.06	344	67932	244201	70615967
Gastritis	21.85	12.06	93	68183	44498	70815670
Pulmonary sepsis	21.80	12.06	21	68255	3286	70856882
Dysdiadochokinesis	21.71	12.06	9	68267	310	70859858
Oliguria	21.64	12.06	46	68230	15005	70845163
Disease recurrence	21.31	12.06	5	68271	37598	70822570
Muscle tone disorder	21.19	12.06	7	68269	125	70860043
Hyperventilation	20.94	12.06	30	68246	7156	70853012
Blood folate increased	20.78	12.06	10	68266	492	70859676
Coombs negative haemolytic anaemia	20.76	12.06	9	68267	347	70859821
Hepatic function abnormal	20.60	12.06	21	68255	67975	70792193
Tension headache	20.50	12.06	21	68255	3540	70856628
Full blood count abnormal	20.22	12.06	4	68272	33874	70826294
Hypertensive crisis	20.17	12.06	52	68224	19210	70840958
Cardiac failure	20.09	12.06	219	68057	143322	70716846
Hypoxia	20.05	12.06	37	68239	93307	70766861
Duodenal ulcer	20.04	12.06	45	68231	15235	70844933
Transaminases increased	19.98	12.06	94	68182	46924	70813244
Haemorrhagic necrotic pancreatitis	19.96	12.06	7	68269	151	70860017
Prescription drug used without a prescription	19.70	12.06	19	68257	2978	70857190
Pseudarthrosis	19.37	12.06	8	68268	273	70859895
Vascular encephalopathy	19.37	12.06	10	68266	573	70859595
Hepatitis toxic	19.33	12.06	23	68253	4576	70855592
Atrial fibrillation	19.18	12.06	266	68010	184082	70676086
Adverse event	19.08	12.06	12	68264	49449	70810719
Hyperglycaemia	18.47	12.06	116	68160	64556	70795612
Head injury	18.46	12.06	5	68271	34136	70826032
Anxiety	18.02	12.06	131	68145	220199	70639969
Cardiogenic shock	18.00	12.06	76	68200	36231	70823937
Pneumobilia	17.76	12.06	7	68269	211	70859957
Internal fixation of fracture	17.74	12.06	8	68268	339	70859829
Gastric ulcer perforation	17.68	12.06	15	68261	1992	70858176
Ill-defined disorder	17.63	12.06	16	68260	54725	70805443
Gastrointestinal sounds abnormal	17.57	12.06	23	68253	5038	70855130
Spontaneous haemorrhage	17.52	12.06	9	68267	510	70859658
Implant site inflammation	17.43	12.06	7	68269	222	70859946
Product packaging confusion	17.37	12.06	7	68269	224	70859944
Lack of application site rotation	17.17	12.06	4	68272	17	70860151
Oropharyngeal discomfort	17.16	12.06	25	68251	6054	70854114
Amnesia	17.09	12.06	15	68261	52140	70808028
Anaemia of malignant disease	17.09	12.06	10	68266	733	70859435
Pulmonary hypertension	17.00	12.06	12	68264	46524	70813644
Tonsillitis	16.97	12.06	25	68251	6115	70854053
Intentional product use issue	16.96	12.06	59	68217	120083	70740085
Localised infection	16.90	12.06	70	68206	33088	70827080
Medication overuse headache	16.90	12.06	10	68266	749	70859419
Acute kidney injury	16.86	12.06	586	67690	474038	70386130
Hyperaemia	16.75	12.06	17	68259	2834	70857334
Somnolence	16.69	12.06	296	67980	215310	70644858
Paraparesis	16.67	12.06	19	68257	3610	70856558
Lividity	16.56	12.06	8	68268	397	70859771
Bulimia nervosa	16.47	12.06	7	68269	257	70859911
International normalised ratio increased	16.46	12.06	33	68243	80693	70779475
Seizure	16.46	12.06	102	68174	177860	70682308
Weight bearing difficulty	16.45	12.06	17	68259	2895	70857273
Spinal cord injury cauda equina	16.43	12.06	6	68270	146	70860022
Rash pruritic	16.34	12.06	22	68254	62969	70797199
Concomitant disease aggravated	16.25	12.06	36	68240	12078	70848090
Hypervolaemia	16.21	12.06	9	68267	39697	70820471
Autoimmune nephritis	16.11	12.06	9	68267	604	70859564
Antineutrophil cytoplasmic antibody positive	15.94	12.06	11	68265	1075	70859093
Joint stiffness	15.83	12.06	7	68269	35169	70824999
Breath sounds normal	15.76	12.06	3	68273	3	70860165
Drain site complication	15.76	12.06	3	68273	3	70860165
Lower gastrointestinal haemorrhage	15.69	12.06	40	68236	14680	70845488
Fluid retention	15.59	12.06	23	68253	63362	70796806
Peritoneal perforation	15.57	12.06	6	68270	170	70859998
Vitamin B6 deficiency	15.41	12.06	7	68269	302	70859866
Arthritis	15.31	12.06	46	68230	97934	70762234
Visual acuity reduced	15.27	12.06	4	68272	27926	70832242
Product impurity	15.20	12.06	5	68271	88	70860080
Knee arthroplasty	15.17	12.06	7	68269	34294	70825874
Somatosensory evoked potentials abnormal	15.16	12.06	6	68270	183	70859985
Prescribed underdose	14.96	12.06	50	68226	21335	70838833
Respiratory alkalosis	14.95	12.06	19	68257	4042	70856126
Throat tightness	14.84	12.06	3	68273	25019	70835149
Lordosis	14.69	12.06	7	68269	337	70859831
Therapy interrupted	14.66	12.06	3	68273	24799	70835369
Peritoneal adhesions	14.61	12.06	7	68269	341	70859827
Preternatural anus	14.61	12.06	5	68271	100	70860068
Necrotising fasciitis	14.56	12.06	22	68254	5504	70854664
Head discomfort	14.52	12.06	36	68240	12987	70847181
Skin haemorrhage	14.51	12.06	31	68245	10149	70850019
Blood uric acid increased	14.42	12.06	29	68247	9100	70851068
Subacute hepatic failure	14.41	12.06	6	68270	209	70859959
Circulatory collapse	14.40	12.06	70	68206	35404	70824764
Colitis	14.39	12.06	108	68168	63706	70796462
Cardiac murmur functional	14.33	12.06	4	68272	39	70860129
Hyperkinesia	14.25	12.06	15	68261	2608	70857560
Oedematous pancreatitis	14.25	12.06	10	68266	1003	70859165
Rhabdomyolysis	14.22	12.06	46	68230	95714	70764454
Condition aggravated	14.20	12.06	524	67752	427111	70433057
Wrong technique in product usage process	14.08	12.06	28	68248	68670	70791498
Foreign body	14.04	12.06	15	68261	2653	70857515
C-reactive protein abnormal	14.02	12.06	10	68266	38569	70821599
Mycobacterium fortuitum infection	14.02	12.06	6	68270	224	70859944
Influenza	14.01	12.06	59	68217	113641	70746527
Cross sensitivity reaction	13.97	12.06	17	68259	3461	70856707
Vasculitis	13.93	12.06	46	68230	19512	70840656
Solar dermatitis	13.87	12.06	6	68270	230	70859938
Hepatic failure	13.83	12.06	99	68177	57526	70802642
Peripheral circulatory failure	13.82	12.06	10	68266	1053	70859115
Abdominal wall cyst	13.81	12.06	4	68272	45	70860123
Pregnancy	13.80	12.06	3	68273	23778	70836390
Urine uric acid decreased	13.76	12.06	5	68271	120	70860048
Wrong product administered	13.75	12.06	27	68249	8324	70851844
Tracheal pain	13.73	12.06	4	68272	46	70860122
Necrolytic migratory erythema	13.69	12.06	3	68273	9	70860159
Rhinorrhoea	13.64	12.06	27	68249	66344	70793824
Acute respiratory distress syndrome	13.36	12.06	12	68264	41242	70818926
Stenosis	13.32	12.06	13	68263	2068	70858100
Pulmonary vein occlusion	13.31	12.06	5	68271	132	70860036
Diarrhoea	13.27	12.06	899	67377	782442	70077726
Lumbar vertebral fracture	13.24	12.06	22	68254	5965	70854203
Genitourinary tract infection	13.16	12.06	6	68270	261	70859907
Insomnia	13.16	12.06	140	68136	217666	70642502
Leukocytosis	13.16	12.06	74	68202	39594	70820574
Intestinal haemorrhage	13.15	12.06	22	68254	5998	70854170
Toxic neuropathy	13.14	12.06	9	68267	869	70859299
Tumour haemorrhage	13.05	12.06	17	68259	3705	70856463
Coma	13.03	12.06	45	68231	91799	70768369
Urinary sediment abnormal	13.03	12.06	5	68271	140	70860028
Leptotrichia infection	13.01	12.06	4	68272	56	70860112
Lung disorder	12.84	12.06	30	68246	69454	70790714
Hyperresponsive to stimuli	12.82	12.06	4	68272	59	70860109
Sensory level abnormal	12.80	12.06	5	68271	147	70860021
Skin irritation	12.79	12.06	29	68247	9880	70850288
Drug ineffective for unapproved indication	12.73	12.06	11	68265	38527	70821641
Petechiae	12.69	12.06	44	68232	19128	70841040
Organic brain syndrome	12.68	12.06	7	68269	459	70859709
Confusional state	12.65	12.06	195	68081	284203	70575965
Anal haemorrhage	12.65	12.06	17	68259	3819	70856349
Viral infection	12.63	12.06	11	68265	38380	70821788
Reactive gastropathy	12.60	12.06	7	68269	465	70859703
Alpha 2 globulin increased	12.56	12.06	5	68271	155	70860013
Polyneuropathy in malignant disease	12.56	12.06	5	68271	155	70860013
Dyspnoea exertional	12.55	12.06	123	68153	78307	70781861
Vision blurred	12.52	12.06	48	68228	94936	70765232
Rash erythematous	12.49	12.06	19	68257	51699	70808469
Anaemia folate deficiency	12.42	12.06	6	68270	298	70859870
Pure white cell aplasia	12.40	12.06	4	68272	66	70860102
Cytomegalovirus infection	12.36	12.06	12	68264	39746	70820422
Product prescribing issue	12.35	12.06	15	68261	3049	70857119
Adrenocortical insufficiency acute	12.32	12.06	14	68262	2652	70857516
Food interaction	12.21	12.06	11	68265	1582	70858586
No adverse event	12.13	12.06	8	68268	32145	70828023
Brain contusion	12.08	12.06	10	68266	1284	70858884
Obstructive airways disorder	12.07	12.06	5	68271	26108	70834060
Laryngeal oedema	12.06	12.06	24	68252	7471	70852697

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N02BB02	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB52	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB72	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D058633	Antipyretics
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35493	anti-pyretic
CHEBI has role	CHEBI:35842	anti-rheumatic drugs
CHEBI has role	CHEBI:49110	peripheral nervous system drugs
CHEBI has role	CHEBI:50266	Prodrugs
CHEBI has role	CHEBI:67079	anti-inflammatory agents
CHEBI has role	CHEBI:73263	cyclooxygenase-3 inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
Zimeta	Kindred Biosciences Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	0.21	acidic
pKa2	5.06	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Transient receptor potential cation channel subfamily A member 1	Ion channel	O75762	TRPA1_HUMAN	BLOCKER	IC50	4.04		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D08190	KEGG_DRUG
N0000167060	NUI
50567-35-6	SECONDARY_CAS_RN
CHEBI:59033	CHEBI
CHEMBL3989803	ChEMBL_ID
C024864	MESH_SUPPLEMENTAL_RECORD_UI
10608	IUPHAR_LIGAND_ID
5907-38-0	SECONDARY_CAS_RN
DB04817	DRUGBANK_ID
934T64RMNJ	UNII
1537943	RXNORM
NOCODE	MMSL
001609	NDDF
006029	NDDF
22165008	SNOMEDCT_US
735071007	SNOMEDCT_US
780831000	SNOMEDCT_US
781025005	SNOMEDCT_US
C0012586	UMLSCUI
D004177	MESH_DESCRIPTOR_UI
CHEMBL461522	ChEMBL_ID
477	INN_ID
3111	PUBCHEM_CID
6150-97-6	SECONDARY_CAS_RN
51996-59-9	SECONDARY_CAS_RN

Pharmaceutical products:

None