metamizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory analgesics, phenylbutazone derivatives 4659 68-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • algocalmin
  • metamizole
  • metamizole sodium
  • metamizol
  • metapyrin
  • methampyrone
  • dipyrone
  • dipyrone monohydrate
  • sulpyrine
  • metamizole magnesium
  • metamizole calcium
A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
  • Molecular weight: 311.36
  • Formula: C13H17N3O4S
  • CLOGP: -1.20
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 81.16
  • ALOGS: -2.09
  • ROTB: 4

Drug dosage:

DoseUnitRoute
3 g O
3 g P
3 g R

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1507.27 12.66 1229 46541 200173 63241079
Product prescribing error 639.37 12.66 337 47433 25952 63415300
Systemic infection 383.59 12.66 141 47629 4519 63436733
Haematochezia 365.67 12.66 311 47459 53233 63388019
Anaemia 340.30 12.66 708 47062 292722 63148530
Agranulocytosis 326.96 12.66 215 47555 24919 63416333
Product monitoring error 325.59 12.66 124 47646 4392 63436860
Drug ineffective 253.90 12.66 249 47521 1044516 62396736
Labelled drug-drug interaction medication error 217.75 12.66 132 47638 13267 63427985
Fracture 201.45 12.66 145 47625 19439 63421813
Haematemesis 178.16 12.66 162 47608 30250 63411002
Joint swelling 162.57 12.66 26 47744 327640 63113612
Polyneuropathy 161.56 12.66 113 47657 14476 63426776
Fall 157.21 12.66 647 47123 391687 63049565
Leukopenia 144.71 12.66 230 47540 77060 63364192
Abdominal discomfort 133.61 12.66 38 47732 320847 63120405
Aspirin-exacerbated respiratory disease 132.28 12.66 42 47728 853 63440399
Systemic lupus erythematosus 131.84 12.66 6 47764 208912 63232340
Toxic epidermal necrolysis 127.38 12.66 124 47646 25210 63416042
Infusion related reaction 125.11 12.66 18 47752 245503 63195749
Abdominal pain lower 122.26 12.66 122 47648 25556 63415696
Pemphigus 120.26 12.66 4 47766 183722 63257530
Synovitis 119.15 12.66 5 47765 186913 63254339
Treatment failure 118.54 12.66 8 47762 199035 63242217
Product dose omission issue 117.49 12.66 18 47752 234295 63206957
Pallor 108.02 12.66 124 47646 30444 63410808
Renal impairment 105.25 12.66 216 47554 88139 63353113
Arthropathy 105.00 12.66 24 47746 234768 63206484
Swelling 100.06 12.66 41 47729 275337 63165915
Drug intolerance 99.80 12.66 54 47716 308607 63132645
Therapeutic product effect decreased 98.78 12.66 14 47756 193173 63248079
Dyspnoea 97.63 12.66 838 46932 660475 62780777
Restlessness 96.61 12.66 115 47655 29338 63411914
Sinusitis 93.99 12.66 27 47743 226626 63214626
Arrhythmia 93.69 12.66 129 47641 38011 63403241
Tachypnoea 93.24 12.66 88 47682 17214 63424038
Stevens-Johnson syndrome 92.90 12.66 104 47666 24846 63416406
Apathy 90.16 12.66 65 47705 8729 63432523
Vomiting 89.90 12.66 723 47047 558894 62882358
Erysipelas 84.66 12.66 60 47710 7845 63433407
Nausea 83.78 12.66 995 46775 853476 62587776
Upper gastrointestinal haemorrhage 83.23 12.66 86 47684 18766 63422486
Alopecia 83.04 12.66 79 47691 337457 63103795
Malaise 82.25 12.66 116 47654 415838 63025414
Product administration error 81.07 12.66 92 47678 22305 63418947
Abdominal pain 79.21 12.66 432 47338 293024 63148228
Pericarditis 76.27 12.66 6 47764 131573 63309679
Drug hypersensitivity 76.08 12.66 73 47697 310614 63130638
Drug-induced liver injury 74.28 12.66 119 47651 40103 63401149
Tachycardia 73.96 12.66 226 47544 117930 63323322
Abdominal pain upper 72.06 12.66 327 47443 206117 63235135
Electrolyte imbalance 70.18 12.66 81 47689 19995 63421257
Pancytopenia 69.86 12.66 195 47575 96738 63344514
Atrial fibrillation 69.21 12.66 219 47551 116417 63324835
Product use issue 69.18 12.66 40 47730 220480 63220772
Lower respiratory tract infection 69.01 12.66 9 47761 132298 63308954
Haematoma 68.42 12.66 106 47664 34714 63406538
Cardiac failure 67.89 12.66 183 47587 88959 63352293
Hypokalaemia 67.26 12.66 201 47569 103603 63337649
Jaundice 66.00 12.66 95 47675 29156 63412096
Ascites 65.17 12.66 113 47657 40615 63400637
Completed suicide 64.87 12.66 15 47755 145658 63295594
Rheumatoid arthritis 64.04 12.66 58 47712 253761 63187491
Oedema peripheral 63.77 12.66 297 47473 189214 63252038
Contraindicated product administered 62.09 12.66 44 47726 217604 63223648
Musculoskeletal stiffness 61.54 12.66 31 47739 184587 63256665
Dysuria 61.18 12.66 99 47671 33639 63407613
Acute kidney injury 60.11 12.66 371 47399 263044 63178208
Acute hepatic failure 59.18 12.66 71 47699 18256 63422996
Maternal exposure during pregnancy 58.29 12.66 48 47722 220014 63221238
Gastritis erosive 58.20 12.66 43 47727 5996 63435256
Dehydration 57.81 12.66 271 47499 173083 63268169
Disturbance in attention 53.50 12.66 100 47670 38089 63403163
Cachexia 53.46 12.66 40 47730 5686 63435566
Nasopharyngitis 53.13 12.66 68 47702 254189 63187063
Therapeutic drug monitoring analysis not performed 52.89 12.66 24 47746 1328 63439924
Drug interaction 52.43 12.66 323 47447 228808 63212444
Helicobacter infection 51.68 12.66 5 47765 92780 63348472
Headache 50.75 12.66 275 47495 632966 62808286
Arthralgia 50.41 12.66 239 47531 569471 62871781
Discomfort 50.19 12.66 32 47738 167342 63273910
Gamma-glutamyltransferase increased 48.78 12.66 90 47680 33941 63407311
Musculoskeletal pain 48.22 12.66 166 47604 92111 63349141
Hyponatraemia 48.14 12.66 189 47581 111711 63329541
Thrombocytopenia 47.99 12.66 233 47537 150924 63290328
Off label use 46.60 12.66 307 47463 674155 62767097
Osteochondrosis 46.26 12.66 22 47748 1355 63439897
Injection site pain 46.01 12.66 20 47750 129780 63311472
Listless 46.00 12.66 28 47742 2832 63438420
Spontaneous haemorrhage 45.17 12.66 17 47753 582 63440670
Reduced facial expression 44.36 12.66 24 47746 1942 63439310
Pyrexia 43.68 12.66 543 47227 469935 62971317
Nasal disorder 43.42 12.66 27 47743 2837 63438415
Concomitant disease aggravated 42.82 12.66 43 47727 9069 63432183
Syncope 42.45 12.66 188 47582 117197 63324055
Weight increased 41.94 12.66 83 47687 260709 63180543
Urosepsis 41.55 12.66 60 47710 18464 63422788
Haemorrhagic erosive gastritis 41.48 12.66 15 47755 458 63440794
Malignant neoplasm progression 41.41 12.66 146 47624 81975 63359277
Rash 40.38 12.66 252 47518 560619 62880633
Cardiac failure congestive 40.19 12.66 10 47760 92423 63348829
Hepatorenal failure 39.28 12.66 16 47754 678 63440574
Stenosis 39.22 12.66 20 47750 1434 63439818
Pelvic fracture 38.72 12.66 49 47721 13299 63427953
Mucosal haemorrhage 37.94 12.66 18 47752 1103 63440149
Psoriatic arthropathy 37.72 12.66 11 47759 91509 63349743
Therapy non-responder 37.62 12.66 6 47764 75895 63365357
Hypersensitivity 37.59 12.66 105 47665 292580 63148672
Hypoaesthesia 37.31 12.66 43 47727 168350 63272902
Urogenital haemorrhage 36.85 12.66 12 47758 265 63440987
Tumour pain 36.55 12.66 19 47751 1418 63439834
Subileus 36.07 12.66 25 47745 3154 63438098
Suspected product quality issue 35.09 12.66 11 47759 214 63441038
Therapeutic product effect incomplete 34.70 12.66 26 47744 125030 63316222
Constipation 34.49 12.66 288 47482 224655 63216597
Gallbladder polyp 34.08 12.66 15 47755 772 63440480
Dizziness 33.57 12.66 481 47289 429444 63011808
Hepatitis toxic 33.24 12.66 24 47746 3229 63438023
Psoriasis 33.11 12.66 12 47758 86945 63354307
Spinal pain 33.10 12.66 45 47725 13094 63428158
Nasal congestion 32.97 12.66 5 47765 65655 63375597
Prescription drug used without a prescription 32.45 12.66 21 47749 2365 63438887
Peripheral swelling 32.25 12.66 98 47672 265844 63175408
Hospitalisation 31.95 12.66 12 47758 85069 63356183
Facial nerve disorder 31.80 12.66 13 47757 556 63440696
Angina pectoris 31.70 12.66 70 47700 30008 63411244
Injury 31.70 12.66 8 47762 73239 63368013
Feeling abnormal 31.69 12.66 39 47731 148353 63292899
Drug reaction with eosinophilia and systemic symptoms 31.52 12.66 75 47695 33761 63407491
Medication error 30.82 12.66 98 47672 52186 63389066
Injection site erythema 30.79 12.66 12 47758 83162 63358090
Type I hypersensitivity 30.74 12.66 22 47748 2920 63438332
Gastrointestinal disorder 30.74 12.66 32 47738 131207 63310045
Ileus 30.58 12.66 46 47724 14679 63426573
Somatic symptom disorder 30.37 12.66 21 47749 2639 63438613
Hepatic enzyme increased 30.32 12.66 67 47703 202261 63238991
Diverticulum intestinal 30.31 12.66 31 47739 6682 63434570
Dyspnoea exertional 30.21 12.66 107 47663 60195 63381057
Circulatory collapse 30.16 12.66 57 47713 21881 63419371
Pleural effusion 29.79 12.66 144 47626 93066 63348186
Heart rate increased 29.66 12.66 17 47753 94221 63347031
Hepatic cyst 29.28 12.66 27 47743 5127 63436125
Delirium 29.13 12.66 94 47676 50447 63390805
Intentional product use issue 29.04 12.66 32 47738 127860 63313392
Paresis 28.95 12.66 20 47750 2510 63438742
Chromaturia 28.88 12.66 48 47722 16669 63424583
Gastrointestinal sounds abnormal 28.58 12.66 24 47746 4027 63437225
Adverse event 28.06 12.66 8 47762 67551 63373701
Therapeutic response decreased 28.05 12.66 6 47764 61519 63379733
Head discomfort 27.99 12.66 42 47728 13373 63427879
Hepatitis cholestatic 27.90 12.66 30 47740 6848 63434404
Immobile 27.84 12.66 28 47742 5915 63435337
Respiratory alkalosis 27.77 12.66 20 47750 2681 63438571
Faecaloma 27.68 12.66 32 47738 7909 63433343
Oliguria 27.34 12.66 34 47736 9067 63432185
Irritable bowel syndrome 27.20 12.66 14 47756 82398 63358854
Electrocardiogram abnormal 27.11 12.66 34 47736 9145 63432107
Bradycardia 27.01 12.66 118 47652 73109 63368143
Psychotic symptom 26.97 12.66 16 47754 1545 63439707
Hepatic failure 26.92 12.66 73 47697 35583 63405669
Bicytopenia 26.79 12.66 19 47751 2486 63438766
Nail toxicity 26.66 12.66 10 47760 339 63440913
Muscle tone disorder 26.52 12.66 8 47762 136 63441116
Illness 26.40 12.66 3 47767 49056 63392196
Amnesia 26.22 12.66 5 47765 55580 63385672
Migraine 25.58 12.66 24 47746 103322 63337930
Painful respiration 25.05 12.66 19 47751 2755 63438497
Acute generalised exanthematous pustulosis 24.96 12.66 36 47734 11063 63430189
Insomnia 24.90 12.66 81 47689 215171 63226081
Thirst decreased 24.88 12.66 9 47761 275 63440977
Blood pressure increased 24.83 12.66 53 47717 162009 63279243
Post-traumatic pain 24.64 12.66 10 47760 420 63440832
Lethargy 24.46 12.66 6 47764 56001 63385251
Vascular encephalopathy 24.39 12.66 10 47760 431 63440821
Hypertensive emergency 24.21 12.66 16 47754 1866 63439386
Decreased appetite 24.19 12.66 292 47478 250760 63190492
Injection site reaction 24.18 12.66 7 47763 58517 63382735
Hepatitis acute 24.14 12.66 32 47738 9088 63432164
Antineutrophil cytoplasmic antibody positive 24.06 12.66 11 47759 619 63440633
Pseudarthrosis 24.00 12.66 10 47760 449 63440803
Type 2 diabetes mellitus 24.00 12.66 9 47761 63859 63377393
Death 23.99 12.66 174 47596 374207 63067045
Gastric mucosa erythema 23.94 12.66 9 47761 307 63440945
Injection site pruritus 23.68 12.66 3 47767 45113 63396139
Disease progression 23.44 12.66 35 47735 122723 63318529
Duodenal ulcer 23.34 12.66 29 47741 7727 63433525
Haematuria 23.34 12.66 61 47709 29096 63412156
Urinary retention 22.84 12.66 62 47708 30239 63411013
Myocardial infarction 22.67 12.66 25 47745 99868 63341384
Device stimulation issue 22.64 12.66 6 47764 62 63441190
Pain in jaw 22.57 12.66 3 47767 43493 63397759
Rheumatic fever 22.30 12.66 3 47767 43108 63398144
Gastric ulcer 22.08 12.66 53 47717 23984 63417268
Suspected product contamination 22.03 12.66 5 47765 25 63441227
Fibromyalgia 21.95 12.66 17 47753 80403 63360849
Febrile infection 21.90 12.66 14 47756 1543 63439709
Patent ductus arteriosus 21.73 12.66 21 47749 4229 63437023
Heart rate decreased 21.70 12.66 4 47766 45556 63395696
Gastroenteritis 21.66 12.66 56 47714 26534 63414718
Cholestatic liver injury 21.66 12.66 17 47753 2593 63438659
Humerus fracture 21.65 12.66 30 47740 8886 63432366
Lividity 21.59 12.66 8 47762 262 63440990
Adverse drug reaction 21.56 12.66 17 47753 79697 63361555
Unevaluable event 21.50 12.66 6 47764 51380 63389872
Inappropriate schedule of product administration 21.48 12.66 28 47742 103937 63337315
Metastatic malignant melanoma 21.47 12.66 13 47757 1302 63439950
Knee arthroplasty 21.46 12.66 7 47763 54199 63387053
Ill-defined disorder 21.41 12.66 18 47752 81737 63359515
Loss of personal independence in daily activities 21.37 12.66 25 47745 97265 63343987
Depressed level of consciousness 21.36 12.66 98 47672 61980 63379272
C-reactive protein increased 21.30 12.66 133 47637 94574 63346678
Thirst 21.22 12.66 38 47732 14003 63427249
Helicobacter gastritis 21.15 12.66 14 47756 1638 63439614
Neuropathy peripheral 21.13 12.66 33 47737 113634 63327618
Foreign body 21.09 12.66 16 47754 2322 63438930
Localised infection 20.98 12.66 60 47710 30150 63411102
Vertigo 20.95 12.66 95 47675 59792 63381460
Hyperkinesia 20.75 12.66 14 47756 1690 63439562
Sensory disturbance 20.66 12.66 37 47733 13635 63427617
Chills 20.58 12.66 151 47619 113227 63328025
Cellulitis 20.32 12.66 19 47751 81939 63359313
Aortic valve stenosis 20.15 12.66 18 47752 3281 63437971
Paranasal sinus inflammation 20.04 12.66 9 47761 486 63440766
Transaminases increased 19.60 12.66 60 47710 31307 63409945
Coombs negative haemolytic anaemia 19.50 12.66 7 47763 209 63441043
Arthritis 19.39 12.66 36 47734 115885 63325367
Necrotising fasciitis 19.38 12.66 17 47753 3024 63438228
Hyperaemia 19.37 12.66 15 47755 2244 63439008
Acute abdomen 19.34 12.66 13 47757 1560 63439692
Peritoneal perforation 18.98 12.66 6 47764 120 63441132
Pneumobilia 18.80 12.66 6 47764 124 63441128
Fluid intake reduced 18.63 12.66 18 47752 3623 63437629
Medication overuse headache 18.34 12.66 10 47760 822 63440430
Peripheral arterial occlusive disease 18.24 12.66 19 47751 4182 63437070
Flank pain 18.21 12.66 39 47731 16371 63424881
Pregnancy 18.05 12.66 3 47767 36833 63404419
Liver function test increased 17.98 12.66 60 47710 32751 63408501
Catheter site inflammation 17.93 12.66 10 47760 859 63440393
Left ventricular hypertrophy 17.83 12.66 21 47749 5294 63435958
Sensory level abnormal 17.80 12.66 6 47764 148 63441104
Gastritis 17.67 12.66 65 47705 37238 63404014
Rhonchi 17.63 12.66 15 47755 2561 63438691
Neutropenia 17.48 12.66 205 47565 174800 63266452
Reactive gastropathy 17.45 12.66 8 47762 453 63440799
Spinal osteoarthritis 17.43 12.66 38 47732 16148 63425104
Hyperglycaemia 17.41 12.66 70 47700 41797 63399455
Mucosal erosion 17.38 12.66 12 47758 1504 63439748
Mesenteric arterial occlusion 17.29 12.66 6 47764 162 63441090
Conjunctivitis 17.15 12.66 44 47726 20752 63420500
Acute respiratory failure 17.10 12.66 61 47709 34424 63406828
Diverticulum intestinal haemorrhagic 17.06 12.66 12 47758 1549 63439703
No adverse event 17.01 12.66 5 47765 41400 63399852
Lordosis 16.98 12.66 7 47763 306 63440946
Stoma site inflammation 16.94 12.66 8 47762 485 63440767
Sepsis 16.94 12.66 183 47587 152940 63288312
Peripheral circulatory failure 16.93 12.66 10 47760 958 63440294
Dermatitis bullous 16.85 12.66 26 47744 8482 63432770
Oesophageal candidiasis 16.76 12.66 21 47749 5642 63435610
Normochromic normocytic anaemia 16.70 12.66 19 47751 4617 63436635
Vasculitis 16.57 12.66 40 47730 18169 63423083
Coronavirus test positive 16.55 12.66 9 47761 736 63440516
C-reactive protein abnormal 16.49 12.66 7 47763 46089 63395163
Adrenal calcification 16.48 12.66 4 47766 28 63441224
Nail avulsion 16.35 12.66 6 47764 191 63441061
Breast cancer metastatic 16.24 12.66 31 47739 11987 63429265
Prerenal failure 16.17 12.66 12 47758 1684 63439568
Upper respiratory tract infection 16.04 12.66 23 47747 82024 63359228
Faeces pale 16.04 12.66 12 47758 1705 63439547
Exposure during pregnancy 15.68 12.66 62 47708 155485 63285767
Brain contusion 15.64 12.66 8 47762 577 63440675
Pulmonary vein occlusion 15.54 12.66 5 47765 106 63441146
Anaemia folate deficiency 15.45 12.66 6 47764 224 63441028
Affective disorder 15.40 12.66 21 47749 6125 63435127
Surgery 15.39 12.66 4 47766 35908 63405344
Adrenomegaly 15.33 12.66 5 47765 111 63441141
Product use in unapproved indication 15.26 12.66 76 47694 179004 63262248
Cardiac murmur functional 15.21 12.66 4 47766 40 63441212
Gastrointestinal infection 15.17 12.66 26 47744 9255 63431997
Internal haemorrhage 15.04 12.66 19 47751 5146 63436106
Abdominal wall cyst 15.03 12.66 4 47766 42 63441210
Urogenital infection bacterial 15.03 12.66 4 47766 42 63441210
Urinary tract infection enterococcal 15.00 12.66 14 47756 2699 63438553
Aortic valve sclerosis 14.98 12.66 10 47760 1186 63440066
Dyschezia 14.98 12.66 13 47757 2281 63438971
Dysphagia 14.95 12.66 116 47654 88469 63352783
Disorientation 14.87 12.66 64 47706 39388 63401864
Lumbar vertebral fracture 14.79 12.66 20 47750 5790 63435462
Cardio-respiratory arrest 14.74 12.66 14 47756 59945 63381307
Leukocytosis 14.73 12.66 48 47722 25887 63415365
Gastric ulcer perforation 14.68 12.66 10 47760 1226 63440026
Myoclonus 14.59 12.66 35 47735 15833 63425419
Bone marrow oedema 14.57 12.66 10 47760 1242 63440010
Spinal instability 14.44 12.66 5 47765 134 63441118
Necrolytic migratory erythema 14.43 12.66 3 47767 9 63441243
Contusion 14.37 12.66 61 47709 149983 63291269
Reticulocyte count increased 14.34 12.66 9 47761 961 63440291
Merycism 14.29 12.66 6 47764 275 63440977
Pericardial drainage 14.20 12.66 6 47764 279 63440973
Thalamus haemorrhage 14.20 12.66 8 47762 701 63440551
Bulimia nervosa 14.20 12.66 7 47763 467 63440785
VIIIth nerve injury 14.19 12.66 3 47767 10 63441242
Shock haemorrhagic 13.96 12.66 26 47744 9869 63431383
Liver injury 13.89 12.66 15 47755 60505 63380747
Ileal stenosis 13.88 12.66 11 47759 1702 63439550
Kyphosis 13.84 12.66 13 47757 2527 63438725
Systemic inflammatory response syndrome 13.78 12.66 19 47751 5602 63435650
Nocturia 13.56 12.66 23 47747 8118 63433134
Blister 13.56 12.66 51 47719 129763 63311489
Fatigue 13.55 12.66 539 47231 887489 62553763
CD8 lymphocytes decreased 13.52 12.66 5 47765 163 63441089
Metastatic gastric cancer 13.46 12.66 5 47765 165 63441087
Product used for unknown indication 13.43 12.66 7 47763 525 63440727
Sinobronchitis 13.43 12.66 5 47765 166 63441086
Anaemia of malignant disease 13.39 12.66 7 47763 528 63440724
Feeling cold 13.37 12.66 44 47726 23844 63417408
Respiratory arrest 13.31 12.66 4 47766 32641 63408611
Vision blurred 13.30 12.66 31 47739 91893 63349359
Autoimmune colitis 13.22 12.66 7 47763 542 63440710
Gastrointestinal tract adenoma 13.22 12.66 6 47764 332 63440920
Chronic fatigue syndrome 13.17 12.66 9 47761 1109 63440143
Petechiae 13.15 12.66 31 47739 13866 63427386
Hyperresponsive to stimuli 13.10 12.66 4 47766 71 63441181
Nutritional condition abnormal 13.09 12.66 8 47762 815 63440437
Mucosal dryness 12.99 12.66 13 47757 2731 63438521
Stress 12.96 12.66 19 47751 67148 63374104
SARS-CoV-2 antibody test negative 12.94 12.66 5 47765 184 63441068
Hyperuricaemia 12.94 12.66 18 47752 5352 63435900
Pulmonary atypical adenomatous hyperplasia 12.85 12.66 4 47766 76 63441176
Femoral neck fracture 12.79 12.66 23 47747 8500 63432752
Body fat disorder 12.74 12.66 5 47765 192 63441060

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1576.94 13.58 1228 37530 127041 34791132
Product prescribing error 406.07 13.58 275 38483 22652 34895521
Systemic infection 299.55 13.58 136 38622 5076 34913097
Product monitoring error 228.87 13.58 107 38651 4274 34913899
Anaemia 202.13 13.58 642 38116 232693 34685480
Drug ineffective 181.78 13.58 145 38613 456606 34461567
Haematochezia 176.38 13.58 237 38521 46297 34871876
Appendicolith 144.65 13.58 100 38658 8501 34909672
Abdominal pain 140.25 13.58 449 38309 163169 34755004
Appendicitis 110.10 13.58 107 38651 14700 34903473
Musculoskeletal pain 102.03 13.58 150 38608 31813 34886360
Death 100.79 13.58 180 38578 397869 34520304
Blood phosphorus increased 96.39 13.58 75 38683 7646 34910527
Completed suicide 95.21 13.58 3 38755 98165 34820008
Labelled drug-drug interaction medication error 94.66 13.58 99 38659 14840 34903333
Agranulocytosis 94.30 13.58 124 38634 23697 34894476
Vomiting 93.34 13.58 529 38229 247092 34671081
Malaise 86.98 13.58 49 38709 185776 34732397
Nausea 85.48 13.58 656 38102 339252 34578921
Abdominal pain upper 85.13 13.58 221 38537 71269 34846904
Constipation 83.92 13.58 337 38421 136645 34781528
Tachypnoea 82.86 13.58 102 38656 18250 34899923
Dyspnoea 79.08 13.58 698 38060 376084 34542089
Product dose omission issue 73.17 13.58 21 38737 119690 34798483
Pallor 71.99 13.58 113 38645 25367 34892806
Cardiac failure congestive 70.02 13.58 6 38752 83264 34834909
Ventricular fibrillation 66.52 13.58 103 38655 22851 34895322
Leukopenia 66.46 13.58 186 38572 62670 34855503
Hyponatraemia 65.34 13.58 221 38537 82470 34835703
Tachycardia 63.01 13.58 222 38536 84550 34833623
Ascites 62.80 13.58 151 38607 46420 34871753
Cardiogenic shock 61.70 13.58 108 38650 26510 34891663
Stress 58.84 13.58 114 38644 30233 34887940
Abdominal distension 57.86 13.58 169 38589 58323 34859850
Electrolyte imbalance 56.99 13.58 75 38683 14337 34903836
Micturition disorder 54.75 13.58 33 38725 2215 34915958
Restlessness 54.72 13.58 100 38658 25382 34892791
Paresis 53.01 13.58 32 38726 2154 34916019
Polyneuropathy 52.05 13.58 73 38685 14823 34903350
Fracture 51.85 13.58 50 38708 6799 34911374
Acute abdomen 51.01 13.58 30 38728 1925 34916248
Neuropathy peripheral 50.14 13.58 15 38743 83248 34834925
Toxicity to various agents 49.27 13.58 92 38666 200270 34717903
Electrocardiogram abnormal 47.67 13.58 55 38703 9192 34908981
Blood uric acid increased 47.54 13.58 56 38702 9568 34908605
Myocardial infarction 47.16 13.58 39 38719 121046 34797127
Dyschezia 44.77 13.58 25 38733 1453 34916720
Condition aggravated 44.28 13.58 364 38394 191832 34726341
Multiple organ dysfunction syndrome 44.13 13.58 185 38573 76381 34841792
Drug abuse 43.68 13.58 28 38730 99068 34819105
Hyperventilation 43.21 13.58 31 38727 2793 34915380
Hospitalisation 43.02 13.58 6 38752 56896 34861277
Respiratory tract haemorrhage 42.66 13.58 23 38735 1247 34916926
Negative pressure pulmonary oedema 42.16 13.58 14 38744 219 34917954
Blood pressure measurement 41.50 13.58 13 38745 167 34918006
Platelet count decreased 41.37 13.58 43 38715 119674 34798499
Interstitial lung disease 40.71 13.58 11 38747 65271 34852902
Pyrexia 40.05 13.58 553 38205 332460 34585713
Mucosal haemorrhage 39.95 13.58 24 38734 1601 34916572
Osteochondrosis 39.81 13.58 21 38737 1089 34917084
Oedema peripheral 39.21 13.58 247 38511 119565 34798608
Neuromuscular block prolonged 38.33 13.58 16 38742 485 34917688
C-reactive protein increased 37.89 13.58 139 38619 53959 34864214
Dry mouth 37.67 13.58 95 38663 30070 34888103
Haematemesis 37.50 13.58 90 38668 27621 34890552
Therapeutic drug monitoring analysis not performed 36.47 13.58 16 38742 549 34917624
Blood pressure increased 36.03 13.58 27 38731 88075 34830098
Hepatic cyst 36.03 13.58 27 38731 2602 34915571
Disease progression 36.02 13.58 40 38718 108037 34810136
Wound 35.34 13.58 61 38697 14803 34903370
Myasthenia gravis 35.30 13.58 41 38717 6899 34911274
Treatment failure 35.12 13.58 5 38753 46692 34871481
Product administration error 34.90 13.58 64 38694 16280 34901893
Cardiac arrest 33.83 13.58 34 38724 96125 34822048
Feeling abnormal 33.60 13.58 14 38744 63221 34854952
Gamma-glutamyltransferase increased 33.36 13.58 89 38669 29142 34889031
Infusion related reaction 32.96 13.58 9 38749 53048 34865125
Cachexia 32.52 13.58 40 38718 7146 34911027
Fall 32.14 13.58 355 38403 202530 34715643
Platelet dysfunction 32.09 13.58 12 38746 270 34917903
Impaired healing 31.44 13.58 59 38699 15275 34902898
Urosepsis 29.74 13.58 52 38706 12747 34905426
Hypertensive crisis 29.26 13.58 42 38716 8709 34909464
Joint swelling 29.12 13.58 15 38743 59875 34858298
Abdominal discomfort 29.07 13.58 15 38743 59820 34858353
Medication error 28.33 13.58 77 38681 25488 34892685
Leptotrichia infection 27.81 13.58 8 38750 75 34918098
Lack of application site rotation 27.81 13.58 8 38750 75 34918098
Therapy non-responder 27.62 13.58 5 38753 39141 34879032
Drug reaction with eosinophilia and systemic symptoms 27.61 13.58 90 38668 32922 34885251
Disturbance in attention 27.61 13.58 77 38681 25868 34892305
Accessory spleen 26.91 13.58 9 38749 144 34918029
Erysipelas 26.89 13.58 30 38728 4833 34913340
Internal fixation of fracture 26.75 13.58 8 38750 87 34918086
Weight bearing difficulty 26.48 13.58 16 38742 1079 34917094
Cold sweat 26.42 13.58 43 38715 9944 34908229
Polyneuropathy in malignant disease 26.33 13.58 10 38748 235 34917938
Drug therapy 25.87 13.58 16 38742 1125 34917048
Osteoma 25.52 13.58 8 38750 103 34918070
Therapeutic product effect decreased 25.48 13.58 4 38754 34739 34883434
Polycystic liver disease 25.45 13.58 8 38750 104 34918069
Analgesic therapy 25.21 13.58 15 38743 983 34917190
Toxic epidermal necrolysis 24.79 13.58 66 38692 21580 34896593
Splenic necrosis 24.65 13.58 8 38750 116 34918057
Dizziness 24.63 13.58 359 38399 218162 34700011
Gastrointestinal adenocarcinoma 24.49 13.58 7 38751 64 34918109
White blood cell count decreased 24.15 13.58 43 38715 95402 34822771
Haemoglobin urine present 23.92 13.58 8 38750 128 34918045
Renal impairment 23.90 13.58 183 38575 94330 34823843
Splenic cyst 23.81 13.58 8 38750 130 34918043
Suspected product contamination 23.67 13.58 7 38751 73 34918100
Activated partial thromboplastin time abnormal 22.90 13.58 8 38750 147 34918026
Coma 22.87 13.58 11 38747 45667 34872506
Iron deficiency 22.83 13.58 29 38729 5352 34912821
Heart rate decreased 22.51 13.58 4 38754 31741 34886432
Iris adhesions 22.46 13.58 9 38749 245 34917928
Cardiovascular insufficiency 22.39 13.58 17 38741 1670 34916503
Gastritis 22.38 13.58 64 38694 21809 34896364
Sleep disorder therapy 22.32 13.58 14 38744 1009 34917164
Cardiac disorder 22.19 13.58 10 38748 43116 34875057
Pulmonary sepsis 21.96 13.58 19 38739 2246 34915927
Loss of personal independence in daily activities 21.82 13.58 5 38753 33174 34884999
Malignant neoplasm progression 21.44 13.58 169 38589 87877 34830296
Implant site inflammation 21.29 13.58 7 38751 106 34918067
Urinary sediment present 21.28 13.58 9 38749 282 34917891
Unevaluable event 21.26 13.58 5 38753 32585 34885588
Hepatorenal failure 21.13 13.58 11 38747 555 34917618
Metastases to soft tissue 20.78 13.58 10 38748 426 34917747
Spinal pain 20.78 13.58 29 38729 5860 34912313
Haematoma 20.69 13.58 69 38689 25536 34892637
Disorientation 20.53 13.58 82 38676 33106 34885067
Lower respiratory tract infection 20.35 13.58 5 38753 31632 34886541
Adenocarcinoma of appendix 20.17 13.58 7 38751 126 34918047
Intestinal haemorrhage 20.08 13.58 22 38736 3474 34914699
Hydrocholecystis 20.07 13.58 10 38748 460 34917713
Musculoskeletal stiffness 19.47 13.58 14 38744 46666 34871507
Lordosis 19.44 13.58 9 38749 351 34917822
Anxiety disorder 19.35 13.58 16 38742 1778 34916395
White blood cells urine positive 19.35 13.58 14 38744 1278 34916895
Pseudarthrosis 19.30 13.58 6 38752 75 34918098
Drug resistance 18.98 13.58 3 38755 25924 34892249
Orthostatic hypotension 18.97 13.58 3 38755 25916 34892257
Spinal osteoarthritis 18.88 13.58 32 38726 7651 34910522
Chills 18.88 13.58 154 38604 80889 34837284
Tracheal atresia 18.84 13.58 4 38754 8 34918165
Suspected product quality issue 18.78 13.58 7 38751 156 34918017
Splenic lesion 18.67 13.58 8 38750 259 34917914
Long QT syndrome 18.51 13.58 19 38739 2784 34915389
Immobile 18.49 13.58 18 38740 2476 34915697
Unresponsive to stimuli 18.44 13.58 4 38754 27565 34890608
Toxic neuropathy 18.43 13.58 10 38748 549 34917624
Febrile infection 18.38 13.58 17 38741 2194 34915979
Blood pressure decreased 18.35 13.58 18 38740 51497 34866676
Thirst 18.24 13.58 32 38726 7863 34910310
Upper gastrointestinal haemorrhage 18.22 13.58 66 38692 25452 34892721
Haematocrit abnormal 18.14 13.58 11 38747 746 34917427
Influenza 18.11 13.58 17 38741 49649 34868524
Flank pain 18.09 13.58 29 38729 6622 34911551
Mineral supplementation 18.06 13.58 6 38752 94 34918079
Muscle spasms 17.90 13.58 35 38723 74966 34843207
Arthropathy 17.80 13.58 4 38754 26903 34891270
Wrong dose 17.78 13.58 10 38748 589 34917584
Depressed level of consciousness 17.69 13.58 94 38664 42747 34875426
Psychotic disorder 17.51 13.58 3 38755 24449 34893724
Flushing 17.50 13.58 7 38751 32413 34885760
Genitourinary tract infection 17.50 13.58 6 38752 104 34918069
Fluid intake reduced 17.39 13.58 21 38737 3680 34914493
Administration site discomfort 17.28 13.58 5 38753 48 34918125
Psoriasis 17.04 13.58 11 38747 38801 34879372
Labelled drug-drug interaction issue 16.98 13.58 8 38750 325 34917848
Dysdiadochokinesis 16.93 13.58 7 38751 207 34917966
Rectal haemorrhage 16.88 13.58 12 38746 40237 34877936
Drug-induced liver injury 16.85 13.58 70 38688 28762 34889411
Haematuria 16.84 13.58 104 38654 49962 34868211
Cardio-respiratory arrest 16.77 13.58 22 38736 55251 34862922
Platelet function test abnormal 16.61 13.58 6 38752 122 34918051
Primary biliary cholangitis 16.59 13.58 7 38751 218 34917955
Urogenital infection bacterial 16.58 13.58 5 38753 56 34918117
Reflux nephropathy 16.35 13.58 5 38753 59 34918114
Chronic fatigue syndrome 16.15 13.58 8 38750 363 34917810
Quality of life decreased 16.09 13.58 21 38737 3980 34914193
Rash 15.92 13.58 164 38594 222588 34695585
Cerebrovascular accident 15.90 13.58 45 38713 84766 34833407
Hyperphosphataemia 15.88 13.58 22 38736 4415 34913758
Sepsis 15.83 13.58 266 38492 166295 34751878
Gastritis haemorrhagic 15.77 13.58 13 38745 1438 34916735
Incorrect route of product administration 15.73 13.58 44 38714 14801 34903372
Contraindicated product administered 15.71 13.58 56 38702 21425 34896748
Encephalopathy 15.52 13.58 10 38748 35309 34882864
Red blood cell abnormality 15.51 13.58 8 38750 396 34917777
Angioedema 15.43 13.58 82 38676 37292 34880881
Papillary renal cell carcinoma 15.41 13.58 7 38751 261 34917912
Spinal cord injury cauda equina 15.38 13.58 6 38752 152 34918021
Breath sounds normal 15.34 13.58 3 38755 3 34918170
Lower gastrointestinal haemorrhage 15.34 13.58 33 38725 9419 34908754
Respiratory arrest 15.23 13.58 6 38752 28037 34890136
Cellulitis 15.13 13.58 22 38736 52929 34865244
Contusion 15.04 13.58 11 38747 36353 34881820
Autoimmune nephritis 15.03 13.58 7 38751 277 34917896
Lung disorder 15.01 13.58 10 38748 34686 34883487
Somatosensory evoked potentials abnormal 14.92 13.58 6 38752 165 34918008
Blood folate increased 14.91 13.58 7 38751 282 34917891
Product prescribing issue 14.81 13.58 15 38743 2164 34916009
Therapeutic response decreased 14.76 13.58 7 38751 29306 34888867
Paraparesis 14.69 13.58 14 38744 1875 34916298
Nail bed inflammation 14.69 13.58 6 38752 172 34918001
Haemorrhagic necrotic pancreatitis 14.69 13.58 6 38752 172 34918001
Adrenocortical insufficiency acute 14.67 13.58 13 38745 1587 34916586
Tremor 14.63 13.58 45 38713 82542 34835631
Jaundice 14.59 13.58 72 38686 31810 34886363
Fear of disease 14.53 13.58 7 38751 299 34917874
Mycobacterium fortuitum infection 14.52 13.58 6 38752 177 34917996
Suicidal ideation 14.51 13.58 14 38744 40374 34877799
Anxiety 14.39 13.58 59 38699 99369 34818804
Blood pressure fluctuation 14.39 13.58 5 38753 25244 34892929
Immune effector cell-associated neurotoxicity syndrome 14.18 13.58 19 38739 3694 34914479
Off label use 14.10 13.58 356 38402 419168 34499005
Therapeutic drug monitoring analysis incorrectly performed 14.07 13.58 7 38751 321 34917852
Coronavirus test positive 14.06 13.58 8 38750 482 34917691
Atheroembolism 14.03 13.58 7 38751 323 34917850
Dehydration 14.01 13.58 212 38546 129757 34788416
Oedematous pancreatitis 13.96 13.58 8 38750 489 34917684
Preternatural anus 13.92 13.58 5 38753 100 34918073
Somnolence 13.87 13.58 186 38572 110930 34807243
Vitamin B6 deficiency 13.87 13.58 6 38752 199 34917974
Basal ganglia haemorrhage 13.79 13.58 10 38748 916 34917257
Fear of falling 13.69 13.58 7 38751 340 34917833
Dermatitis allergic 13.65 13.58 26 38732 6804 34911369
Product packaging confusion 13.59 13.58 4 38754 41 34918132
Upper respiratory tract irritation 13.59 13.58 4 38754 41 34918132

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 3065.61 12.06 2365 75866 272873 79393284
Product prescribing error 1021.97 12.06 603 77628 44210 79621947
Systemic infection 658.59 12.06 275 77956 9477 79656680
Anaemia 550.01 12.06 1291 76940 443724 79222433
Product monitoring error 534.54 12.06 231 78000 8675 79657482
Haematochezia 528.49 12.06 534 77697 87111 79579046
Agranulocytosis 332.79 12.06 307 77924 44723 79621434
Drug ineffective 321.25 12.06 354 77877 1080559 78585598
Labelled drug-drug interaction medication error 291.18 12.06 231 78000 27419 79638738
Fracture 237.87 12.06 186 78045 21615 79644542
Haematemesis 194.44 12.06 248 77983 52016 79614141
Abdominal pain 190.96 12.06 822 77409 388747 79277410
Tachypnoea 179.74 12.06 188 78043 31875 79634282
Completed suicide 179.34 12.06 17 78214 245750 79420407
Pallor 179.10 12.06 233 77998 49829 79616328
Malaise 176.21 12.06 134 78097 489735 79176422
Joint swelling 175.39 12.06 35 78196 288611 79377546
Dyspnoea 173.59 12.06 1432 76799 855593 78810564
Leukopenia 172.33 12.06 364 77867 116149 79550008
Vomiting 172.24 12.06 1179 77052 664649 79001508
Nausea 157.21 12.06 1528 76703 955668 78710489
Appendicolith 153.80 12.06 99 78132 8452 79657705
Restlessness 151.88 12.06 207 78024 46285 79619872
Polyneuropathy 148.77 12.06 149 78082 24002 79642155
Abdominal pain upper 146.74 12.06 518 77713 223301 79442856
Fall 145.15 12.06 895 77336 486734 79179423
Infusion related reaction 141.77 12.06 27 78204 230210 79435947
Musculoskeletal pain 141.29 12.06 311 77920 102043 79564114
Abdominal discomfort 137.28 12.06 38 78193 250689 79415468
Tachycardia 136.52 12.06 434 77797 177334 79488823
Product dose omission issue 136.50 12.06 37 78194 247500 79418657
Aspirin-exacerbated respiratory disease 134.62 12.06 49 78182 1158 79664999
Electrolyte imbalance 125.17 12.06 153 78078 30728 79635429
Constipation 124.00 12.06 578 77653 282472 79383685
Treatment failure 123.79 12.06 12 78219 170474 79495683
Synovitis 122.78 12.06 6 78225 150728 79515429
Renal impairment 121.85 12.06 386 77845 157397 79508760
Product administration error 121.41 12.06 153 78078 31693 79634464
Ascites 121.01 12.06 244 77987 75318 79590839
Arthropathy 119.75 12.06 16 78215 177095 79489062
Toxic epidermal necrolysis 111.51 12.06 175 78056 44406 79621751
Therapeutic product effect decreased 107.97 12.06 16 78215 163847 79502310
Oedema peripheral 102.35 12.06 504 77727 251784 79414373
Hyponatraemia 99.29 12.06 391 77840 177457 79488700
Appendicitis 99.19 12.06 112 78119 20682 79645475
Sinusitis 99.13 12.06 34 78197 195467 79470690
Abdominal pain lower 98.53 12.06 138 78093 31644 79634513
Cardiac failure congestive 91.33 12.06 15 78216 142387 79523770
Musculoskeletal stiffness 89.48 12.06 30 78201 174978 79491179
Blood phosphorus increased 85.17 12.06 75 78156 10272 79655885
Pyrexia 84.74 12.06 1027 77204 677682 78988475
Erysipelas 84.07 12.06 76 78155 10774 79655383
Therapeutic drug monitoring analysis not performed 83.81 12.06 40 78191 1896 79664261
Drug intolerance 82.97 12.06 82 78149 264037 79402120
Cachexia 82.68 12.06 76 78155 11007 79655150
Osteochondrosis 82.64 12.06 40 78191 1956 79664201
Injection site pain 82.54 12.06 14 78217 129824 79536333
Blood pressure increased 82.20 12.06 53 78178 211307 79454850
Lower respiratory tract infection 82.00 12.06 14 78217 129206 79536951
Pemphigus 80.97 12.06 4 78227 99578 79566579
Paresis 80.77 12.06 51 78180 4210 79661947
Dehydration 79.65 12.06 465 77766 247722 79418435
Disturbance in attention 78.89 12.06 162 78069 50639 79615518
Electrocardiogram abnormal 77.88 12.06 89 78142 16648 79649509
Systemic lupus erythematosus 77.15 12.06 13 78218 121136 79545021
Upper gastrointestinal haemorrhage 75.22 12.06 141 78090 41239 79624918
Haematoma 73.58 12.06 160 78071 52035 79614122
Jaundice 72.33 12.06 161 78070 53188 79612969
Nasopharyngitis 71.78 12.06 86 78145 253795 79412362
Drug-induced liver injury 71.76 12.06 183 78048 65934 79600223
Pericarditis 71.44 12.06 9 78222 104227 79561930
Abdominal distension 70.78 12.06 268 77963 119382 79546775
Dysuria 70.47 12.06 155 78076 50796 79615361
Arthralgia 68.71 12.06 308 77923 571495 79094662
Gamma-glutamyltransferase increased 68.57 12.06 160 78071 54520 79611637
Mucosal haemorrhage 67.40 12.06 38 78193 2548 79663609
Death 65.18 12.06 310 77921 566204 79099953
Lethargy 63.82 12.06 4 78227 81288 79584869
Feeling abnormal 63.16 12.06 39 78192 159160 79506997
Alopecia 61.62 12.06 82 78149 231273 79434884
Rheumatoid arthritis 60.66 12.06 69 78162 208401 79457756
Medication error 60.51 12.06 176 78055 68466 79597691
Toxicity to various agents 59.48 12.06 213 78018 421327 79244830
Hypokalaemia 59.23 12.06 289 77942 143751 79522406
Multiple organ dysfunction syndrome 58.89 12.06 254 77977 119992 79546165
Apathy 58.68 12.06 68 78163 12909 79653248
Therapy non-responder 58.56 12.06 10 78221 92295 79573862
Swelling 58.54 12.06 76 78155 216635 79449522
Product use issue 58.32 12.06 72 78159 209750 79456407
Acute abdomen 58.10 12.06 37 78194 3100 79663057
Interstitial lung disease 58.07 12.06 19 78212 112581 79553576
Hepatorenal failure 57.00 12.06 27 78204 1258 79664899
Drug reaction with eosinophilia and systemic symptoms 55.93 12.06 164 78067 64080 79602077
Ventricular fibrillation 55.81 12.06 107 78124 31819 79634338
Myocardial infarction 55.71 12.06 59 78172 184070 79482087
Urosepsis 55.45 12.06 96 78135 26399 79639758
Suspected product quality issue 55.36 12.06 18 78213 299 79665858
Maternal exposure during pregnancy 54.78 12.06 33 78198 136505 79529652
Disease progression 54.75 12.06 60 78171 184302 79481855
Acute hepatic failure 53.97 12.06 102 78129 30011 79636146
Mental status changes 53.45 12.06 3 78228 66956 79599201
Off label use 53.18 12.06 602 77629 906613 78759544
Malignant neoplasm progression 53.17 12.06 269 77962 135721 79530436
Drug hypersensitivity 52.91 12.06 136 78095 298780 79367377
Stevens-Johnson syndrome 52.86 12.06 118 78113 39048 79627109
Dizziness 52.41 12.06 765 77466 525676 79140481
Dyschezia 52.27 12.06 34 78197 2954 79663203
Blood uric acid increased 52.21 12.06 65 78166 13295 79652862
Helicobacter infection 50.33 12.06 5 78226 69699 79596458
Arrhythmia 48.25 12.06 151 78080 61121 79605036
Psoriasis 48.20 12.06 14 78217 89573 79576584
Neuropathy peripheral 47.74 12.06 41 78190 141264 79524893
Gastritis erosive 47.65 12.06 56 78175 10791 79655366
Nasal disorder 47.37 12.06 35 78196 3734 79662423
Nasal congestion 47.03 12.06 9 78222 76543 79589614
Hospitalisation 46.70 12.06 17 78214 94219 79571938
Syncope 46.21 12.06 318 77913 179131 79487026
Hepatic cyst 45.90 12.06 42 78189 6047 79660110
Therapeutic product effect incomplete 45.58 12.06 43 78188 141602 79524555
Suspected product contamination 45.31 12.06 12 78219 92 79666065
Chills 44.90 12.06 290 77941 159944 79506213
Thrombocytopenia 44.87 12.06 427 77804 264832 79401325
Immobile 44.75 12.06 44 78187 6929 79659228
Haematuria 44.74 12.06 159 78072 68677 79597480
Psoriatic arthropathy 44.21 12.06 11 78220 77988 79588169
Negative pressure pulmonary oedema 43.55 12.06 14 78217 224 79665933
Cardiogenic shock 43.40 12.06 114 78117 41800 79624357
Micturition disorder 43.13 12.06 34 78197 3994 79662163
Folliculitis 42.66 12.06 3 78228 55377 79610780
Subileus 42.62 12.06 39 78192 5615 79660542
Hypoaesthesia 42.43 12.06 69 78162 179283 79486874
Rash 42.08 12.06 364 77867 577994 79088163
Lordosis 41.85 12.06 16 78215 435 79665722
Heart rate decreased 41.68 12.06 9 78222 70307 79595850
Cellulitis 41.50 12.06 28 78203 109032 79557125
Irritable bowel syndrome 41.16 12.06 6 78225 62235 79603922
Peripheral swelling 40.87 12.06 132 78099 269485 79396672
Loss of personal independence in daily activities 40.86 12.06 25 78206 102555 79563602
Disorientation 40.80 12.06 145 78086 62631 79603526
Fibromyalgia 40.75 12.06 7 78224 64333 79601824
Hypersensitivity 40.72 12.06 127 78104 262112 79404045
Spinal pain 40.69 12.06 62 78169 15330 79650827
Gastrointestinal disorder 40.62 12.06 36 78195 122169 79543988
Platelet count decreased 40.58 12.06 81 78150 194583 79471574
Sepsis 40.38 12.06 423 77808 269005 79397152
Adverse drug reaction 40.38 12.06 8 78223 66384 79599773
Hyperventilation 40.17 12.06 44 78187 7855 79658302
Respiratory tract haemorrhage 40.11 12.06 24 78207 1799 79664358
Tumour pain 39.82 12.06 26 78205 2273 79663884
Migraine 39.75 12.06 18 78213 87475 79578682
Discomfort 39.41 12.06 39 78192 125578 79540579
Drug abuse 39.04 12.06 62 78169 162629 79503528
Spontaneous haemorrhage 38.81 12.06 18 78213 799 79665358
Heart rate increased 38.43 12.06 37 78194 120687 79545470
Febrile infection 37.47 12.06 29 78202 3317 79662840
Haemorrhagic erosive gastritis 37.36 12.06 17 78214 722 79665435
Atrial fibrillation 37.23 12.06 326 77905 197560 79468597
Bradycardia 37.16 12.06 244 77987 135313 79530844
Pancytopenia 35.97 12.06 282 77949 165463 79500694
Inappropriate schedule of product administration 35.93 12.06 47 78184 133581 79532576
Listless 35.88 12.06 30 78201 3831 79662326
Fluid intake reduced 35.46 12.06 37 78194 6251 79659906
Injection site swelling 35.04 12.06 3 78228 47129 79619028
Weight increased 34.70 12.06 147 78084 277239 79388918
Thirst 34.53 12.06 64 78167 18555 79647602
Type I hypersensitivity 34.45 12.06 31 78200 4367 79661790
Acute kidney injury 34.35 12.06 707 77524 518697 79147460
Pain in jaw 34.14 12.06 3 78228 46148 79620009
Injection site erythema 34.12 12.06 17 78214 78180 79587977
Gastritis 33.92 12.06 114 78117 47879 79618278
Intentional product use issue 33.71 12.06 61 78170 152051 79514106
Acute generalised exanthematous pustulosis 32.87 12.06 60 78171 17194 79648963
Flank pain 32.85 12.06 65 78166 19779 79646378
Urogenital haemorrhage 32.85 12.06 17 78214 960 79665197
Respiratory arrest 32.84 12.06 8 78223 57542 79608615
Drug interaction 32.51 12.06 580 77651 414603 79251554
Depressed level of consciousness 32.20 12.06 183 78048 96469 79569688
Exposure during pregnancy 32.18 12.06 31 78200 101101 79565056
Therapeutic response decreased 31.56 12.06 13 78218 66840 79599317
Cardio-respiratory arrest 31.45 12.06 36 78195 108474 79557683
Cardiac arrest 31.43 12.06 77 78154 172019 79494138
Oliguria 31.43 12.06 57 78174 16252 79649905
Blood pressure measurement 31.33 12.06 13 78218 440 79665717
Faecaloma 31.16 12.06 47 78184 11517 79654640
Urogenital infection bacterial 31.00 12.06 9 78222 100 79666057
Type 2 diabetes mellitus 30.59 12.06 9 78222 57113 79609044
Coronavirus test positive 30.54 12.06 17 78214 1112 79665045
C-reactive protein increased 30.50 12.06 224 78007 128803 79537354
Depression 30.22 12.06 110 78121 216680 79449477
White blood cell count decreased 30.06 12.06 90 78141 188198 79477959
Hepatitis cholestatic 30.05 12.06 51 78180 13801 79652356
Cardiac failure 29.59 12.06 256 77975 154586 79511571
Hepatitis acute 29.55 12.06 54 78177 15488 79650669
Unresponsive to stimuli 29.50 12.06 9 78222 55779 79610378
Pelvic fracture 29.26 12.06 47 78184 12157 79654000
Contusion 29.23 12.06 64 78167 148712 79517445
Neuromuscular block prolonged 29.21 12.06 16 78215 1014 79665143
Cardiac disorder 29.14 12.06 14 78217 65743 79600414
Angina pectoris 29.03 12.06 114 78117 51618 79614539
Reduced facial expression 28.88 12.06 23 78208 2742 79663415
Blood pressure fluctuation 28.69 12.06 15 78216 67130 79599027
Headache 28.35 12.06 461 77770 653311 79012846
Platelet dysfunction 28.28 12.06 12 78219 430 79665727
Lack of application site rotation 27.97 12.06 8 78223 84 79666073
Adverse event 27.96 12.06 12 78219 60202 79605955
Blood pressure decreased 27.76 12.06 34 78197 99432 79566725
Chronic fatigue syndrome 27.75 12.06 17 78214 1330 79664827
Unevaluable event 27.58 12.06 10 78221 55575 79610582
Psychotic disorder 27.35 12.06 4 78227 41398 79624759
Injection site reaction 26.94 12.06 10 78221 54775 79611382
Drug therapy 26.92 12.06 16 78215 1185 79664972
Analgesic therapy 26.77 12.06 15 78216 994 79665163
Full blood count abnormal 26.53 12.06 4 78227 40470 79625687
Condition aggravated 26.49 12.06 661 77570 500463 79165694
Somnolence 26.41 12.06 354 77877 238627 79427530
Orthostatic hypotension 26.39 12.06 11 78220 56153 79610004
Dry mouth 26.32 12.06 162 78069 87857 79578300
Osteoma 26.14 12.06 8 78223 108 79666049
Polyneuropathy in malignant disease 25.95 12.06 10 78221 278 79665879
Drug resistance 25.85 12.06 5 78226 42208 79623949
Product used for unknown indication 25.62 12.06 17 78214 1527 79664630
Amnesia 25.62 12.06 15 78216 63042 79603115
Decreased appetite 25.60 12.06 475 77756 341943 79324214
Facial nerve disorder 25.54 12.06 13 78218 709 79665448
Gastritis haemorrhagic 25.43 12.06 21 78210 2636 79663521
Pulmonary sepsis 24.90 12.06 24 78207 3688 79662469
Myasthenia gravis 24.86 12.06 40 78191 10359 79655798
Accessory spleen 24.63 12.06 9 78222 215 79665942
Hypertensive crisis 24.11 12.06 59 78172 20711 79645446
Therapy cessation 23.97 12.06 4 78227 37558 79628599
Sleep disorder therapy 23.89 12.06 14 78217 1010 79665147
Flushing 23.77 12.06 31 78200 88237 79577920
Nail toxicity 23.71 12.06 10 78221 353 79665804
Polycystic liver disease 23.00 12.06 8 78223 165 79665992
Iron deficiency 22.81 12.06 39 78192 10615 79655542
Splenic necrosis 22.73 12.06 8 78223 171 79665986
Vertigo 22.48 12.06 130 78101 68952 79597205
Lower gastrointestinal haemorrhage 22.23 12.06 49 78182 16076 79650081
Bicytopenia 22.01 12.06 25 78206 4645 79661512
C-reactive protein abnormal 21.89 12.06 10 78221 48357 79617800
Delirium 21.78 12.06 150 78081 84477 79581680
Duodenal ulcer 21.73 12.06 49 78182 16320 79649837
Thirst decreased 21.71 12.06 9 78222 304 79665853
Gallbladder polyp 21.70 12.06 13 78218 977 79665180
Rash pruritic 21.60 12.06 23 78208 71606 79594551
Flatulence 21.48 12.06 91 78140 42633 79623524
Post-traumatic pain 21.41 12.06 10 78221 451 79665706
Transaminases increased 21.37 12.06 104 78127 51639 79614518
Arthritis 21.29 12.06 51 78180 114829 79551328
Ill-defined disorder 21.18 12.06 20 78211 65855 79600302
Knee arthroplasty 21.09 12.06 8 78223 43240 79622917
Ileus 21.00 12.06 65 78166 26146 79640011
Joint stiffness 20.85 12.06 7 78224 40823 79625334
Dysdiadochokinesis 20.81 12.06 9 78222 338 79665819
Therapy interrupted 20.77 12.06 3 78228 31338 79634819
Gastric ulcer perforation 20.69 12.06 17 78214 2118 79664039
Rhinorrhoea 20.19 12.06 27 78204 76047 79590110
Long QT syndrome 20.18 12.06 27 78204 5928 79660229
Hyperglycaemia 20.12 12.06 128 78103 70207 79595950
Anxiety 20.04 12.06 152 78079 248360 79417797
Allodynia 20.03 12.06 15 78216 1633 79664524
Hydrocholecystis 20.03 12.06 10 78221 523 79665634
Blood folate increased 19.98 12.06 10 78221 526 79665631
Therapeutic drug monitoring analysis incorrectly performed 19.97 12.06 11 78220 705 79665452
Coombs negative haemolytic anaemia 19.89 12.06 9 78222 377 79665780
Haemorrhagic necrotic pancreatitis 19.78 12.06 7 78224 152 79666005
Angioedema 19.70 12.06 135 78096 75900 79590257
Splenic cyst 19.70 12.06 8 78223 256 79665901
Muscle tone disorder 19.70 12.06 7 78224 154 79666003
Drug ineffective for unapproved indication 19.69 12.06 13 78218 51225 79614932
Aortic arteriosclerosis 19.56 12.06 33 78198 8885 79657272
Hypervolaemia 19.05 12.06 9 78222 42681 79623476
Cerebrovascular accident 18.97 12.06 83 78148 155209 79510948
Hyperaemia 18.80 12.06 19 78212 3091 79663066
Metastases to soft tissue 18.78 12.06 10 78221 599 79665558
Pseudarthrosis 18.77 12.06 8 78223 290 79665867
Peripheral arterial occlusive disease 18.71 12.06 31 78200 8227 79657930
Vascular encephalopathy 18.56 12.06 10 78221 613 79665544
Influenza 18.56 12.06 65 78166 129541 79536616
Anaemia of malignant disease 18.51 12.06 11 78220 814 79665343
Spinal osteoarthritis 18.51 12.06 47 78184 16880 79649277
Hip arthroplasty 18.49 12.06 6 78225 35750 79630407
Rheumatic fever 18.29 12.06 3 78228 28522 79637635
International normalised ratio increased 17.86 12.06 35 78196 84686 79581471
Throat tightness 17.75 12.06 3 78228 27904 79638253
Head discomfort 17.70 12.06 42 78189 14460 79651697
Coma 17.62 12.06 46 78185 100603 79565554
Activated partial thromboplastin time abnormal 17.62 12.06 8 78223 338 79665819
Gastrointestinal sounds abnormal 17.44 12.06 24 78207 5411 79660746
Vision blurred 17.34 12.06 50 78181 105848 79560309
Iron deficiency anaemia 17.28 12.06 60 78171 25612 79640545
Circulatory collapse 17.23 12.06 78 78153 37590 79628567
Disease recurrence 17.21 12.06 11 78220 44098 79622059
Painful respiration 17.15 12.06 19 78212 3434 79662723
Subacute hepatic failure 17.07 12.06 7 78224 230 79665927
Pneumobilia 17.01 12.06 7 78224 232 79665925
Internal fixation of fracture 17.00 12.06 8 78223 367 79665790
Hepatitis toxic 16.93 12.06 23 78208 5124 79661033
Wrong technique in product usage process 16.92 12.06 29 78202 73846 79592311
Road traffic accident 16.89 12.06 11 78220 43653 79622504
Pregnancy 16.83 12.06 3 78228 26848 79639309
Reactive gastropathy 16.72 12.06 9 78222 551 79665606
Rhabdomyolysis 16.67 12.06 49 78182 103082 79563075
Gait inability 16.58 12.06 20 78211 58897 79607260
Rectal haemorrhage 16.54 12.06 31 78200 76269 79589888
Product packaging confusion 16.52 12.06 7 78224 250 79665907
Head injury 16.49 12.06 8 78223 37361 79628796
Hepatic function abnormal 16.47 12.06 29 78202 73078 79593079
Bulimia nervosa 16.39 12.06 7 78224 255 79665902
Lung disorder 16.36 12.06 34 78197 80523 79585634
Fluid retention 16.36 12.06 27 78204 69782 79596375
Wound 16.26 12.06 180 78051 115999 79550158
Cyanosis 16.21 12.06 58 78173 25124 79641033
Pulmonary hypertension 16.17 12.06 14 78217 48066 79618091
Prescription drug used without a prescription 16.16 12.06 20 78211 4065 79662092
Spinal cord injury cauda equina 16.09 12.06 6 78225 152 79666005
Papillary renal cell carcinoma 16.06 12.06 7 78224 268 79665889
Dementia 16.05 12.06 57 78174 24602 79641555
Colitis 16.04 12.06 125 78106 73182 79592975
Hypoxia 16.01 12.06 50 78181 103193 79562964
Implant site inflammation 15.99 12.06 7 78224 271 79665886
Concomitant disease aggravated 15.92 12.06 38 78193 13129 79653028
Breath sounds normal 15.71 12.06 3 78228 3 79666154
Paraparesis 15.66 12.06 19 78212 3784 79662373
Lividity 15.57 12.06 8 78223 445 79665712
Basal ganglia haemorrhage 15.56 12.06 13 78218 1658 79664499
Necrotising fasciitis 15.47 12.06 24 78207 6026 79660131
Peritoneal perforation 15.46 12.06 6 78225 170 79665987
Prostatic specific antigen abnormal 15.44 12.06 8 78223 453 79665704
Adrenal calcification 15.42 12.06 4 78227 28 79666129
Localised infection 15.14 12.06 75 78156 37500 79628657
Visual acuity reduced 15.14 12.06 5 78226 29464 79636693
Viral infection 15.12 12.06 12 78219 43004 79623153
Gastroenteritis viral 15.08 12.06 3 78228 24828 79641329
Medication overuse headache 15.03 12.06 10 78221 902 79665255
Hypertensive emergency 15.01 12.06 16 78215 2769 79663388
Nocturia 14.97 12.06 38 78193 13643 79652514
Tonsillitis 14.94 12.06 25 78206 6689 79659468
Product impurity 14.90 12.06 5 78226 92 79666065
No adverse event 14.89 12.06 9 78222 37183 79628974
Helicobacter gastritis 14.88 12.06 15 78216 2434 79663723
Suicidal ideation 14.86 12.06 33 78198 76307 79589850
Rash erythematous 14.83 12.06 21 78210 57748 79608409
Weight bearing difficulty 14.77 12.06 17 78214 3204 79662953
Somatosensory evoked potentials abnormal 14.72 12.06 6 78225 194 79665963
Incisional hernia 14.69 12.06 15 78216 2471 79663686
Dyspnoea exertional 14.61 12.06 140 78091 86933 79579224
Atheroembolism 14.56 12.06 7 78224 337 79665820
Vitamin B6 deficiency 14.52 12.06 7 78224 339 79665818
Preternatural anus 14.52 12.06 5 78226 100 79666057
Autoimmune nephritis 14.40 12.06 9 78222 730 79665427
Toxic neuropathy 14.38 12.06 10 78221 970 79665187
Peritoneal adhesions 14.35 12.06 7 78224 348 79665809
Pleural effusion 14.35 12.06 211 78020 145051 79521106
Cardiac murmur functional 14.25 12.06 4 78227 39 79666118
Mycobacterium fortuitum infection 14.17 12.06 6 78225 214 79665943
Hepatic enzyme increased 14.10 12.06 113 78118 182497 79483660
Seizure 14.06 12.06 118 78113 188716 79477441
Muscle spasms 14.02 12.06 107 78124 174623 79491534
Diverticulum intestinal 14.02 12.06 28 78203 8577 79657580
Nightmare 13.98 12.06 4 78227 25857 79640300
Antineutrophil cytoplasmic antibody positive 13.93 12.06 11 78220 1295 79664862
Contraindicated product administered 13.83 12.06 94 78137 157444 79508713
Petechiae 13.79 12.06 48 78183 20517 79645640
Respiratory alkalosis 13.78 12.06 19 78212 4292 79661865
Urinary retention 13.76 12.06 99 78132 56531 79609626
Oropharyngeal discomfort 13.75 12.06 25 78206 7141 79659016
Neoplasm malignant 13.75 12.06 7 78224 31803 79634354
Splenic lesion 13.74 12.06 8 78223 570 79665587
Asthma 13.74 12.06 77 78154 135018 79531139
Abdominal wall cyst 13.73 12.06 4 78227 45 79666112
Gastric disorder 13.72 12.06 10 78221 37423 79628734
Tracheal pain 13.65 12.06 4 78227 46 79666111
Cytomegalovirus infection 13.65 12.06 13 78218 42631 79623526
Necrolytic migratory erythema 13.63 12.06 3 78228 9 79666148
Sensory disturbance 13.61 12.06 39 78192 15038 79651119
Solar dermatitis 13.55 12.06 6 78225 239 79665918
Hyperkinesia 13.53 12.06 15 78216 2714 79663443
Urine uric acid decreased 13.47 12.06 5 78226 125 79666032
Acute respiratory distress syndrome 13.45 12.06 14 78217 44053 79622104
Deep vein thrombosis 13.37 12.06 67 78164 120852 79545305
Mesenteric arterial occlusion 13.36 12.06 6 78225 247 79665910
Non-small cell lung cancer 13.25 12.06 23 78208 6337 79659820
Ventricular tachycardia 13.17 12.06 13 78218 41922 79624235
Skin irritation 13.12 12.06 32 78199 11208 79654949
Administration site discomfort 13.11 12.06 5 78226 135 79666022
Chronic gastritis 13.11 12.06 18 78213 4050 79662107
Conjunctivitis 13.10 12.06 55 78176 25660 79640497
Drug withdrawal syndrome 13.09 12.06 9 78222 34709 79631448
Intestinal haemorrhage 13.08 12.06 23 78208 6403 79659754
Immune-mediated hepatitis 13.04 12.06 17 78214 3639 79662518
Catheter site inflammation 13.02 12.06 10 78221 1131 79665026
Emotional distress 13.01 12.06 12 78219 39957 79626200
Peripheral circulatory failure 12.98 12.06 10 78221 1136 79665021
Leptotrichia infection 12.93 12.06 4 78227 56 79666101
Prerenal failure 12.89 12.06 17 78214 3681 79662476
Swelling face 12.89 12.06 32 78199 71180 79594977
Upper respiratory tract infection 12.86 12.06 46 78185 91122 79575035
Gouty arthritis 12.85 12.06 11 78220 1450 79664707
Cross sensitivity reaction 12.84 12.06 17 78214 3695 79662462
Oedematous pancreatitis 12.81 12.06 10 78221 1158 79664999
Foreign body 12.81 12.06 15 78216 2879 79663278
Pulmonary vein occlusion 12.81 12.06 5 78226 144 79666013
Wound haemorrhage 12.79 12.06 18 78213 4143 79662014
Urinary sediment abnormal 12.74 12.06 5 78226 146 79666011
Wheezing 12.69 12.06 65 78166 116599 79549558
Genitourinary tract infection 12.68 12.06 6 78225 279 79665878
Hepatic failure 12.64 12.06 103 78128 61109 79605048
Insomnia 12.63 12.06 167 78064 245003 79421154
Hyperresponsive to stimuli 12.56 12.06 4 78227 62 79666095
Anal haemorrhage 12.55 12.06 18 78213 4216 79661941
Alpha 2 globulin increased 12.46 12.06 5 78226 155 79666002
Cardiovascular insufficiency 12.45 12.06 15 78216 2966 79663191
Drain site complication 12.42 12.06 3 78228 15 79666142
Product use in unapproved indication 12.37 12.06 172 78059 250187 79415970
Neutropenic colitis 12.36 12.06 21 78210 5686 79660471
Pure white cell aplasia 12.33 12.06 4 78227 66 79666091
Organic brain syndrome 12.31 12.06 7 78224 477 79665680
Haematocrit abnormal 12.30 12.06 11 78220 1537 79664620
Lip erosion 12.23 12.06 11 78220 1549 79664608
Anaemia folate deficiency 12.22 12.06 6 78225 303 79665854
Device malfunction 12.20 12.06 3 78228 21445 79644712
Lung neoplasm malignant 12.18 12.06 6 78225 27786 79638371
Dystonia 12.16 12.06 3 78228 21396 79644761
Dry eye 12.12 12.06 11 78220 36920 79629237
Sensory level abnormal 12.09 12.06 5 78226 168 79665989
Obstructive airways disorder 12.07 12.06 8 78223 31451 79634706

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BB02 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB52 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB72 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D058633 Antipyretics
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:49110 peripheral nervous system drugs
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:73263 cyclooxygenase-3 inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Zimeta Kindred Biosciences Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.21 acidic
pKa2 5.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Transient receptor potential cation channel subfamily A member 1 Ion channel BLOCKER IC50 4.04 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D08190 KEGG_DRUG
N0000167060 NUI
50567-35-6 SECONDARY_CAS_RN
5907-38-0 SECONDARY_CAS_RN
CHEBI:59033 CHEBI
C024864 MESH_SUPPLEMENTAL_RECORD_UI
10608 IUPHAR_LIGAND_ID
6150-97-6 SECONDARY_CAS_RN
51996-59-9 SECONDARY_CAS_RN
DB04817 DRUGBANK_ID
934T64RMNJ UNII
1537943 RXNORM
NOCODE MMSL
001609 NDDF
006029 NDDF
22165008 SNOMEDCT_US
735071007 SNOMEDCT_US
780831000 SNOMEDCT_US
781025005 SNOMEDCT_US
C0012586 UMLSCUI
D004177 MESH_DESCRIPTOR_UI
CHEMBL3989803 ChEMBL_ID
CHEMBL461522 ChEMBL_ID
3111 PUBCHEM_CID
477 INN_ID

Pharmaceutical products:

None