metamizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory analgesics, phenylbutazone derivatives 4659 68-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • algocalmin
  • metamizole
  • metamizole sodium
  • metamizol
  • metapyrin
  • methampyrone
  • dipyrone
  • dipyrone monohydrate
  • sulpyrine
  • metamizole magnesium
  • metamizole calcium
A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
  • Molecular weight: 311.36
  • Formula: C13H17N3O4S
  • CLOGP: -1.20
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 81.16
  • ALOGS: -2.09
  • ROTB: 4

Drug dosage:

DoseUnitRoute
3 g O
3 g P
3 g R

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1257.61 12.35 967 37974 141467 50424716
Product prescribing error 490.88 12.35 264 38677 20697 50545486
Haematochezia 297.31 12.35 246 38695 39636 50526547
Agranulocytosis 267.13 12.35 180 38761 21241 50544942
Anaemia 217.23 12.35 549 38392 251907 50314276
Product monitoring error 208.77 12.35 79 38862 2685 50563498
Drug ineffective 191.91 12.35 210 38731 819123 49747060
Fracture 185.25 12.35 131 38810 16702 50549481
Systemic infection 178.77 12.35 67 38874 2216 50563967
Polyneuropathy 146.58 12.35 100 38841 12031 50554152
Haematemesis 133.72 12.35 134 38807 27591 50538592
Aspirin-exacerbated respiratory disease 132.34 12.35 42 38899 832 50565351
Fall 123.45 12.35 547 38394 334385 50231798
Joint swelling 113.56 12.35 25 38916 245261 50320922
Product dose omission issue 105.19 12.35 10 38931 183828 50382355
Abdominal pain lower 97.35 12.35 101 38840 21655 50544528
Leukopenia 95.81 12.35 180 38761 67348 50498835
Pallor 91.98 12.35 101 38840 23098 50543085
Labelled drug-drug interaction medication error 91.57 12.35 71 38870 10406 50555777
Abdominal discomfort 86.54 12.35 35 38906 231606 50334577
Systemic lupus erythematosus 84.99 12.35 6 38935 140616 50425567
Product administration error 83.77 12.35 89 38852 19610 50546573
Infusion related reaction 83.20 12.35 15 38926 169542 50396641
Synovitis 82.05 12.35 3 38938 123862 50442321
Apathy 81.31 12.35 58 38883 7490 50558693
Abdominal pain 78.81 12.35 375 38566 235853 50330330
Toxic epidermal necrolysis 77.40 12.35 88 38853 20904 50545279
Treatment failure 77.37 12.35 8 38933 137629 50428554
Restlessness 77.10 12.35 96 38845 25077 50541106
Pemphigus 76.01 12.35 4 38937 120162 50446021
Dyspnoea 74.60 12.35 694 38247 546914 50019269
Stevens-Johnson syndrome 73.20 12.35 87 38854 21665 50544518
Erysipelas 71.70 12.35 51 38890 6557 50559626
Therapeutic product effect decreased 69.02 12.35 11 38930 136039 50430144
Vomiting 68.86 12.35 596 38345 460162 50106021
Drug-induced liver injury 68.80 12.35 96 38845 27999 50538184
Sinusitis 68.34 12.35 23 38918 170535 50395648
Drug intolerance 65.70 12.35 44 38897 219060 50347123
Swelling 64.85 12.35 37 38904 200835 50365348
Drug hypersensitivity 64.42 12.35 59 38882 250951 50315232
Abdominal pain upper 61.36 12.35 264 38677 159045 50407138
Nausea 61.26 12.35 818 38123 704580 49861603
Arrhythmia 59.52 12.35 98 38843 33034 50533149
Arthropathy 58.71 12.35 24 38917 157882 50408301
Tachypnoea 58.71 12.35 64 38877 14513 50551670
Completed suicide 57.91 12.35 15 38926 131874 50434309
Jaundice 55.53 12.35 84 38857 26345 50539838
Lower respiratory tract infection 54.90 12.35 5 38936 95196 50470987
Malaise 54.62 12.35 110 38831 335422 50230761
Electrolyte imbalance 53.41 12.35 66 38875 17103 50549080
Alopecia 51.40 12.35 68 38873 244979 50321204
Drug interaction 51.37 12.35 295 38646 199326 50366857
Rheumatoid arthritis 49.16 12.35 50 38891 202500 50363683
Pericarditis 48.58 12.35 3 38938 78686 50487497
Haematoma 47.89 12.35 85 38856 30425 50535758
Pyrexia 47.70 12.35 474 38467 379729 50186454
Osteochondrosis 47.40 12.35 21 38920 1073 50565110
Pancytopenia 46.16 12.35 156 38785 83874 50482309
Gamma-glutamyltransferase increased 45.81 12.35 82 38859 29541 50536642
Nasal disorder 45.56 12.35 26 38915 2282 50563901
Maternal exposure during pregnancy 45.35 12.35 34 38907 159744 50406439
Disturbance in attention 45.28 12.35 84 38857 31102 50535081
Tachycardia 44.45 12.35 173 38768 99590 50466593
Malignant neoplasm progression 44.27 12.35 134 38807 67990 50498193
Stenosis 42.71 12.35 20 38921 1163 50565020
Hepatorenal failure 41.11 12.35 16 38925 587 50565596
Oedema peripheral 40.98 12.35 234 38707 157727 50408456
Reduced facial expression 39.88 12.35 21 38920 1573 50564610
Syncope 39.86 12.35 171 38770 102831 50463352
Acute hepatic failure 39.02 12.35 54 38887 15623 50550560
Medication error 39.00 12.35 86 38855 36018 50530165
Nasopharyngitis 38.96 12.35 55 38886 192872 50373311
Product use issue 38.46 12.35 35 38906 149440 50416743
Musculoskeletal stiffness 38.21 12.35 26 38915 128455 50437728
Arthralgia 37.51 12.35 192 38749 438510 50127673
Ascites 37.14 12.35 84 38857 35777 50530406
Listless 36.95 12.35 23 38918 2367 50563816
Cardiac failure 36.45 12.35 135 38806 75905 50490278
Injection site pain 36.45 12.35 20 38921 111004 50455179
Subileus 36.33 12.35 24 38917 2735 50563448
Hypokalaemia 36.31 12.35 149 38792 87843 50478340
Cardiac failure congestive 36.26 12.35 10 38931 84372 50481811
Renal impairment 36.00 12.35 134 38807 75527 50490656
Somatic symptom disorder 35.98 12.35 21 38920 1923 50564260
Tumour pain 35.97 12.35 18 38923 1212 50564971
Hepatitis toxic 35.89 12.35 24 38917 2792 50563391
Suspected product quality issue 35.85 12.35 11 38930 194 50565989
Musculoskeletal pain 35.32 12.35 129 38812 72048 50494135
Concomitant disease aggravated 35.18 12.35 37 38904 8054 50558129
Gallbladder polyp 35.02 12.35 15 38926 706 50565477
Rash 34.34 12.35 197 38744 437274 50128909
Constipation 34.01 12.35 252 38689 185456 50380727
Urogenital haemorrhage 33.97 12.35 11 38930 233 50565950
Atrial fibrillation 33.45 12.35 161 38780 101584 50464599
Dysuria 33.20 12.35 70 38871 28434 50537749
Dehydration 32.68 12.35 215 38726 152234 50413949
Dizziness 32.08 12.35 407 38534 345962 50220221
Therapeutic drug monitoring analysis not performed 32.05 12.35 14 38927 691 50565492
Facial nerve disorder 32.04 12.35 13 38928 533 50565650
Type I hypersensitivity 32.02 12.35 21 38920 2364 50563819
Angina pectoris 31.30 12.35 65 38876 26123 50540060
Weight increased 31.27 12.35 68 38873 201823 50364360
Spinal pain 31.17 12.35 40 38901 10763 50555420
Bicytopenia 30.86 12.35 19 38922 1917 50564266
Gastrointestinal sounds abnormal 30.40 12.35 24 38917 3610 50562573
Headache 29.00 12.35 250 38691 506285 50059898
Nasal congestion 28.63 12.35 3 38938 51117 50515066
Respiratory alkalosis 28.62 12.35 20 38921 2499 50563684
Contraindicated product administered 28.56 12.35 44 38897 148914 50417269
Thrombocytopenia 28.55 12.35 182 38759 127491 50438692
Thirst 28.50 12.35 38 38903 10612 50555571
Injection site erythema 28.47 12.35 11 38930 74925 50491258
Faecaloma 28.26 12.35 31 38910 7077 50559106
Therapeutic product effect incomplete 27.90 12.35 18 38923 91497 50474686
Cachexia 27.73 12.35 25 38916 4508 50561675
Delirium 27.55 12.35 78 38863 38114 50528069
Muscle tone disorder 27.09 12.35 8 38933 123 50566060
Upper gastrointestinal haemorrhage 26.88 12.35 46 38895 15989 50550194
Nail toxicity 26.70 12.35 10 38931 330 50565853
Antineutrophil cytoplasmic antibody positive 26.04 12.35 11 38930 500 50565683
Discomfort 25.99 12.35 27 38914 108353 50457830
Post-traumatic pain 25.72 12.35 10 38931 366 50565817
Thirst decreased 25.66 12.35 9 38932 245 50565938
Acute generalised exanthematous pustulosis 25.64 12.35 33 38908 8905 50557278
Drug reaction with eosinophilia and systemic symptoms 25.54 12.35 63 38878 28361 50537822
Immobile 25.41 12.35 25 38916 5029 50561154
Prescription drug used without a prescription 25.37 12.35 16 38925 1684 50564499
Vascular encephalopathy 25.36 12.35 10 38931 380 50565803
Hepatic failure 25.34 12.35 68 38873 32215 50533968
Helicobacter infection 25.23 12.35 4 38937 49698 50516485
Ileus 24.93 12.35 40 38901 13189 50552994
Pseudarthrosis 24.81 12.35 10 38931 403 50565780
Psoriasis 24.80 12.35 11 38930 68989 50497194
Pelvic fracture 24.74 12.35 37 38904 11483 50554700
Hypersensitivity 24.65 12.35 84 38857 215077 50351106
Insomnia 24.59 12.35 62 38879 174803 50391380
Hospitalisation 24.15 12.35 11 38930 67926 50498257
Hepatitis acute 23.79 12.35 30 38911 7931 50558252
Acute kidney injury 23.69 12.35 274 38667 227784 50338399
Urinary retention 23.48 12.35 58 38883 26132 50540051
Localised infection 23.45 12.35 57 38884 25428 50540755
Chromaturia 23.34 12.35 41 38900 14549 50551634
Vasculitis 23.28 12.35 40 38901 13951 50552232
Blood pressure increased 23.04 12.35 42 38899 133090 50433093
Lividity 22.74 12.35 8 38933 220 50565963
Device stimulation issue 22.51 12.35 6 38935 62 50566121
Heart rate increased 22.47 12.35 16 38925 77234 50488949
Feeling abnormal 22.25 12.35 39 38902 125453 50440730
Psychotic symptom 22.19 12.35 13 38928 1199 50564984
Gastric ulcer 22.16 12.35 50 38891 21255 50544928
Death 22.14 12.35 153 38788 325226 50240957
Therapy non-responder 22.01 12.35 6 38935 51016 50515167
Suspected product contamination 21.91 12.35 5 38936 25 50566158
Peripheral circulatory failure 21.84 12.35 10 38931 552 50565631
Head discomfort 21.71 12.35 34 38907 10985 50555198
Gastritis erosive 21.47 12.35 23 38918 5111 50561072
Aortic valve stenosis 21.41 12.35 18 38923 2957 50563226
Injection site reaction 21.36 12.35 6 38935 50026 50516157
Paranasal sinus inflammation 21.33 12.35 9 38932 408 50565775
Hypoaesthesia 21.27 12.35 41 38900 127216 50438967
Injection site pruritus 21.09 12.35 3 38938 40408 50525775
Haemorrhagic erosive gastritis 21.08 12.35 8 38933 274 50565909
Gastrointestinal disorder 21.03 12.35 25 38916 94431 50471752
Lethargy 20.97 12.35 6 38935 49426 50516757
Medication overuse headache 20.68 12.35 10 38931 625 50565558
Fluid intake reduced 20.66 12.35 18 38923 3104 50563079
Bradycardia 20.48 12.35 101 38840 64325 50501858
Myocardial infarction 20.43 12.35 23 38918 89004 50477179
Gastroenteritis 20.29 12.35 51 38890 23230 50542953
Coombs negative haemolytic anaemia 20.05 12.35 7 38934 188 50565995
Vertigo 19.99 12.35 86 38855 51746 50514437
Acute abdomen 19.99 12.35 13 38928 1443 50564740
Off label use 19.83 12.35 252 38689 474174 50092009
Therapeutic response decreased 19.55 12.35 6 38935 47225 50518958
Necrotising fasciitis 19.25 12.35 16 38925 2588 50563595
Sensory level abnormal 19.19 12.35 6 38935 113 50566070
Left ventricular hypertrophy 19.03 12.35 21 38920 4824 50561359
Pneumobilia 18.99 12.35 6 38935 117 50566066
Peritoneal perforation 18.85 12.35 6 38935 120 50566063
Unevaluable event 18.80 12.35 6 38935 46060 50520123
Foreign body 18.63 12.35 14 38927 1957 50564226
Oliguria 18.53 12.35 27 38914 8189 50557994
Fluid retention 18.32 12.35 8 38933 50641 50515542
Stoma site inflammation 18.24 12.35 8 38933 399 50565784
Amnesia 18.17 12.35 5 38936 42255 50523928
Nail avulsion 18.06 12.35 6 38935 138 50566045
Conjunctivitis 18.05 12.35 39 38902 16106 50550077
Knee arthroplasty 17.94 12.35 3 38938 35843 50530340
Affective disorder 17.88 12.35 21 38920 5160 50561023
Spontaneous haemorrhage 17.85 12.35 7 38934 262 50565921
Patent ductus arteriosus 17.56 12.35 18 38923 3802 50562381
Flank pain 17.40 12.35 34 38907 13081 50553102
Sensory disturbance 17.34 12.35 32 38909 11797 50554386
Faeces pale 17.32 12.35 12 38929 1479 50564704
Injury 17.27 12.35 8 38933 48917 50517266
Liver function test increased 17.22 12.35 51 38890 25555 50540628
Neuropathy peripheral 17.21 12.35 30 38911 96727 50469456
Diverticulum intestinal 17.17 12.35 22 38919 5911 50560272
Internal haemorrhage 17.10 12.35 19 38922 4398 50561785
Gastritis 17.02 12.35 60 38881 32923 50533260
Peripheral arterial occlusive disease 16.87 12.35 17 38924 3520 50562663
Decreased appetite 16.84 12.35 232 38709 200691 50365492
Urogenital infection bacterial 16.51 12.35 4 38937 27 50566156
Lumbar vertebral fracture 16.48 12.35 19 38922 4578 50561605
Anaemia folate deficiency 16.47 12.35 6 38935 183 50566000
Merycism 16.40 12.35 6 38935 185 50565998
No adverse event 16.39 12.35 3 38938 33575 50532608
Painful respiration 16.33 12.35 14 38927 2361 50563822
Ill-defined disorder 16.32 12.35 11 38930 54643 50511540
Heart rate decreased 16.30 12.35 4 38937 36493 50529690
Haematuria 16.27 12.35 50 38891 25563 50540620
Cancer fatigue 16.15 12.35 4 38937 30 50566153
Hyperglycaemia 16.09 12.35 63 38878 36342 50529841
Brain contusion 16.05 12.35 8 38933 534 50565649
Urinary tract infection enterococcal 16.04 12.35 14 38927 2420 50563763
Inappropriate schedule of product administration 16.00 12.35 19 38922 71812 50494371
Peripheral swelling 15.96 12.35 93 38848 205843 50360340
Chills 15.89 12.35 128 38813 96559 50469624
Product used for unknown indication 15.77 12.35 7 38934 359 50565824
Urosepsis 15.76 12.35 36 38905 15429 50550754
Adverse event 15.69 12.35 7 38934 43756 50522427
Migraine 15.64 12.35 21 38920 75259 50490924
Bone marrow oedema 15.61 12.35 9 38932 805 50565378
Reticulocyte count increased 15.57 12.35 9 38932 809 50565374
Transaminases increased 15.57 12.35 52 38889 27772 50538411
Cellulitis 15.48 12.35 19 38922 70779 50495404
Hepatic enzyme increased 15.47 12.35 54 38887 137326 50428857
Pulmonary vein occlusion 15.43 12.35 5 38936 106 50566077
VIIIth nerve injury 15.22 12.35 3 38938 6 50566177
Cardiac murmur functional 15.12 12.35 4 38937 40 50566143
Hepatitis cholestatic 15.12 12.35 21 38920 6096 50560087
Myoclonus 15.10 12.35 34 38907 14436 50551747
Disease progression 15.07 12.35 32 38909 95834 50470349
Prescribed underdose 15.02 12.35 36 38905 15913 50550270
Prerenal failure 15 12.35 11 38930 1482 50564701
C-reactive protein increased 14.99 12.35 95 38846 66379 50499804
Metastatic malignant melanoma 14.95 12.35 10 38931 1164 50565019
Metastatic gastric cancer 14.93 12.35 5 38936 118 50566065
Duodenal ulcer 14.89 12.35 22 38919 6753 50559430
Coronavirus test positive 14.84 12.35 8 38933 628 50565555
Contusion 14.83 12.35 41 38900 112142 50454041
Kyphosis 14.72 12.35 13 38928 2282 50563901
Psoriatic arthropathy 14.68 12.35 9 38932 47023 50519160
Cardio-respiratory arrest 14.60 12.35 12 38929 53880 50512303
Circulatory collapse 14.57 12.35 41 38900 19959 50546224
Necrolytic migratory erythema 14.36 12.35 3 38938 9 50566174
Autoimmune colitis 14.33 12.35 7 38934 447 50565736
Lordosis 14.24 12.35 6 38935 271 50565912
Mucosal dryness 14.14 12.35 13 38928 2404 50563779
Cholestatic liver injury 14.08 12.35 12 38929 2009 50564174
Pleural effusion 14.02 12.35 109 38832 81345 50484838
Wrong patient received product 13.73 12.35 11 38930 1689 50564494
Petechiae 13.73 12.35 30 38911 12482 50553701
CD8 lymphocytes decreased 13.71 12.35 5 38936 153 50566030
Sinobronchitis 13.67 12.35 5 38936 154 50566029
Fatigue 13.64 12.35 428 38513 707173 49859010
Chronic fatigue syndrome 13.62 12.35 9 38932 1026 50565157
Systemic inflammatory response syndrome 13.49 12.35 18 38923 5031 50561152
Gastrointestinal tract adenoma 13.30 12.35 6 38935 320 50565863
Piloerection 13.30 12.35 6 38935 320 50565863
Ileus paralytic 13.29 12.35 16 38925 4034 50562149
Defaecation disorder 13.12 12.35 7 38934 538 50565645
Loss of personal independence in daily activities 13.12 12.35 21 38920 70029 50496154
Hyperkinesia 13.04 12.35 10 38931 1442 50564741
Cerebrovascular accident 12.96 12.35 34 38907 94646 50471537
Adverse drug reaction 12.96 12.35 14 38927 55208 50510975
Gastric mucosa erythema 12.89 12.35 5 38936 182 50566001
Gastrointestinal infection 12.80 12.35 21 38920 7053 50559130
Peripheral nerve lesion 12.75 12.35 6 38935 353 50565830
Rhonchi 12.71 12.35 12 38929 2295 50563888
Herpes zoster 12.54 12.35 22 38919 70764 50495419
Febrile infection 12.53 12.35 9 38932 1175 50565008
Unresponsive to stimuli 12.47 12.35 4 38937 30605 50535578
Substance dependence 12.46 12.35 5 38936 199 50565984
Pancreatic failure 12.45 12.35 8 38933 870 50565313
Cardiomyopathy alcoholic 12.42 12.35 3 38938 20 50566163
Hypertensive emergency 12.38 12.35 10 38931 1553 50564630

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1214.47 13.28 917 28265 101940 29443405
Product prescribing error 290.76 13.28 195 28987 17781 29527564
Systemic infection 171.50 13.28 68 29114 2033 29543312
Haematochezia 140.91 13.28 178 29004 36805 29508540
Drug ineffective 118.32 13.28 111 29071 363059 29182286
Anaemia 118.18 13.28 450 28732 200501 29344844
Product monitoring error 91.51 13.28 47 29135 2598 29542747
Death 90.16 13.28 124 29058 341960 29203385
Agranulocytosis 85.65 13.28 103 29079 20237 29525108
Abdominal pain 81.76 13.28 306 28876 135051 29410294
Pallor 81.31 13.28 102 29080 20922 29524423
Musculoskeletal pain 79.50 13.28 119 29063 28834 29516511
Completed suicide 76.00 13.28 3 29179 90243 29455102
Leukopenia 73.66 13.28 166 29016 55037 29490308
Abdominal pain upper 58.77 13.28 162 29020 60831 29484514
Fracture 58.04 13.28 48 29134 6005 29539340
Electrolyte imbalance 57.41 13.28 63 29119 11211 29534134
Malaise 56.33 13.28 45 29137 159557 29385788
Labelled drug-drug interaction medication error 51.87 13.28 62 29120 12097 29533248
Acute abdomen 51.79 13.28 28 29154 1719 29543626
Product dose omission issue 50.69 13.28 16 29166 96367 29448978
Vomiting 49.29 13.28 368 28814 211892 29333453
Paresis 47.52 13.28 27 29155 1827 29543518
Dyspnoea 44.61 13.28 505 28677 326227 29219118
Negative pressure pulmonary oedema 44.37 13.28 14 29168 209 29545136
Blood pressure measurement 43.43 13.28 13 29169 161 29545184
Nausea 43.10 13.28 455 28727 288800 29256545
Tachycardia 43.03 13.28 163 29019 72247 29473098
Neuromuscular block prolonged 41.36 13.28 16 29166 447 29544898
Disturbance in attention 41.17 13.28 75 29107 21349 29523996
C-reactive protein increased 41.07 13.28 116 29066 44147 29501198
Dyschezia 40.36 13.28 21 29161 1192 29544153
Mucosal haemorrhage 38.58 13.28 22 29160 1499 29543846
Tachypnoea 38.47 13.28 60 29122 15055 29530290
Neuropathy peripheral 36.97 13.28 12 29170 71015 29474330
Platelet dysfunction 36.58 13.28 12 29170 204 29545141
Myocardial infarction 36.55 13.28 33 29149 110263 29435082
Polyneuropathy 36.31 13.28 52 29130 12100 29533245
Pyrexia 34.54 13.28 434 28748 287188 29258157
Appendicolith 34.20 13.28 28 29154 3452 29541893
Micturition disorder 34.05 13.28 22 29160 1879 29543466
Restlessness 33.39 13.28 70 29112 22075 29523270
Fall 33.37 13.28 293 28889 176885 29368460
Oedema peripheral 33.35 13.28 195 28987 103362 29441983
Weight bearing difficulty 31.65 13.28 16 29166 855 29544490
Gamma-glutamyltransferase increased 30.84 13.28 76 29106 26661 29518684
Impaired healing 30.65 13.28 51 29131 13507 29531838
Toxic epidermal necrolysis 30.48 13.28 60 29122 18093 29527252
Constipation 29.94 13.28 204 28978 113956 29431389
Toxicity to various agents 29.80 13.28 81 29101 173580 29371765
Cachexia 29.79 13.28 34 29148 6315 29539030
Leptotrichia infection 28.74 13.28 8 29174 75 29545270
Dizziness 28.45 13.28 299 28883 189385 29355960
Blood pressure increased 28.35 13.28 19 29163 73784 29471561
Accessory spleen 27.94 13.28 9 29173 144 29545201
Interstitial lung disease 27.90 13.28 11 29171 57707 29487638
Electrocardiogram abnormal 27.46 13.28 35 29147 7287 29538058
Product administration error 27.36 13.28 50 29132 14260 29531085
Hospitalisation 27.27 13.28 6 29176 45982 29499363
Therapeutic drug monitoring analysis not performed 27.03 13.28 12 29170 478 29544867
Feeling abnormal 26.94 13.28 10 29172 54435 29490910
Treatment failure 25.98 13.28 3 29179 36936 29508409
Malignant neoplasm progression 25.68 13.28 142 29040 73717 29471628
Hydrocholecystis 25.59 13.28 10 29172 287 29545058
Suspected product contamination 25.50 13.28 7 29175 62 29545283
Infusion related reaction 25.47 13.28 6 29176 43880 29501465
Wound 25.45 13.28 44 29138 12019 29533326
Platelet count decreased 25.41 13.28 40 29142 104632 29440713
Depressed level of consciousness 25.18 13.28 87 29095 36855 29508490
Product prescribing issue 24.66 13.28 15 29167 1152 29544193
Hypertensive crisis 24.06 13.28 34 29148 7814 29537531
Long QT syndrome 23.96 13.28 19 29163 2239 29543106
Iris adhesions 23.69 13.28 9 29173 239 29545106
Contraindicated product administered 23.30 13.28 54 29128 18212 29527133
Hepatorenal failure 23.01 13.28 11 29171 520 29544825
Tension headache 22.54 13.28 15 29167 1346 29543999
Angioedema 22.48 13.28 76 29106 31839 29513506
Cardiac arrest 22.44 13.28 31 29151 85560 29459785
Cold sweat 22.36 13.28 35 29147 8807 29536538
Erysipelas 22.19 13.28 24 29158 4201 29541144
Implant site inflammation 22.15 13.28 7 29175 105 29545240
Medication error 22.07 13.28 58 29124 21153 29524192
Drug abuse 21.89 13.28 28 29154 79855 29465490
Drug reaction with eosinophilia and systemic symptoms 21.82 13.28 69 29113 27923 29517422
Osteochondrosis 21.35 13.28 12 29170 795 29544550
Thirst 21.21 13.28 29 29153 6462 29538883
Hyperventilation 21.13 13.28 18 29164 2344 29543001
Suspected product quality issue 20.47 13.28 7 29175 136 29545209
Joint swelling 20.12 13.28 12 29170 49618 29495727
Pseudarthrosis 20.07 13.28 6 29176 74 29545271
Immobile 19.86 13.28 17 29165 2228 29543117
Appendicitis 19.81 13.28 33 29149 8746 29536599
Thrombosis 19.53 13.28 9 29173 43036 29502309
Mineral supplementation 19.50 13.28 6 29176 82 29545263
Febrile infection 19.43 13.28 16 29166 1988 29543357
Hepatic cyst 19.35 13.28 17 29165 2308 29543037
Tracheal atresia 19.30 13.28 4 29178 8 29545337
Therapeutic product effect decreased 19.26 13.28 3 29179 29448 29515897
Toxic neuropathy 19.02 13.28 9 29173 416 29544929
Intestinal haemorrhage 18.87 13.28 19 29163 3060 29542285
Abdominal discomfort 18.84 13.28 12 29170 47891 29497454
Haematoma 18.82 13.28 58 29124 23154 29522191
Chronic fatigue syndrome 18.80 13.28 8 29174 287 29545058
Flank pain 18.76 13.28 26 29156 5867 29539478
Genitourinary tract infection 18.51 13.28 6 29176 98 29545247
Jaundice 18.25 13.28 67 29115 29229 29516116
Pulmonary sepsis 18.25 13.28 15 29167 1859 29543486
Dysdiadochokinesis 18.25 13.28 7 29175 191 29545154
Adrenocortical insufficiency acute 18.21 13.28 13 29169 1307 29544038
Therapy partial responder 18.17 13.28 24 29158 5175 29540170
Platelet function test abnormal 18.13 13.28 6 29176 105 29545240
Vertigo 18.07 13.28 55 29127 21806 29523539
Haematemesis 17.66 13.28 59 29123 24567 29520778
Tonsillitis 17.43 13.28 15 29167 1980 29543365
Disease progression 17.42 13.28 34 29148 81882 29463463
Haemorrhagic necrotic pancreatitis 17.25 13.28 6 29176 123 29545222
Urogenital infection bacterial 17.16 13.28 5 29177 56 29545289
Paraparesis 16.93 13.28 14 29168 1750 29543595
Reflux nephropathy 16.92 13.28 5 29177 59 29545286
Cardiovascular disorder 16.80 13.28 31 29151 8904 29536441
Fear of disease 16.69 13.28 7 29175 242 29545103
Therapy non-responder 16.47 13.28 5 29177 30906 29514439
Blood folate increased 16.45 13.28 7 29175 251 29545094
Thrombocytopenia 16.33 13.28 204 28978 134619 29410726
Spinal cord injury cauda equina 16.29 13.28 6 29176 146 29545199
Somatosensory evoked potentials abnormal 16.06 13.28 6 29176 152 29545193
Breath sounds normal 15.69 13.28 3 29179 3 29545342
Nail bed inflammation 15.63 13.28 6 29176 164 29545181
Unevaluable event 15.60 13.28 5 29177 29846 29515499
Oedematous pancreatitis 15.59 13.28 8 29174 441 29544904
Unresponsive to stimuli 15.47 13.28 3 29179 25123 29520222
Drug intolerance 15.39 13.28 15 29167 48364 29496981
Coma 15.35 13.28 10 29172 39440 29505905
Vitamin B6 deficiency 15.27 13.28 6 29176 175 29545170
Mycobacterium fortuitum infection 15.27 13.28 6 29176 175 29545170
Food interaction 15.10 13.28 10 29172 890 29544455
Product packaging confusion 14.93 13.28 4 29178 32 29545313
Hyponatraemia 14.91 13.28 116 29066 67517 29477828
Flushing 14.90 13.28 5 29177 28987 29516358
Spinal pain 14.80 13.28 21 29161 4843 29540502
Autoimmune hepatitis 14.76 13.28 18 29164 3584 29541761
Fear of falling 14.68 13.28 7 29175 329 29545016
Quality of life decreased 14.51 13.28 17 29165 3245 29542100
Preternatural anus 14.49 13.28 5 29177 100 29545245
Lack of application site rotation 14.48 13.28 3 29179 6 29545339
Wrong product administered 14.44 13.28 20 29162 4511 29540834
Oral herpes 14.44 13.28 20 29162 4512 29540833
Paraplegia 14.38 13.28 15 29167 2519 29542826
Target skin lesion 14.16 13.28 3 29179 7 29545338
Flatulence 14.12 13.28 44 29138 17665 29527680
Aspirin-exacerbated respiratory disease 14.11 13.28 7 29175 359 29544986
Creatinine renal clearance abnormal 14.11 13.28 6 29176 215 29545130
Upper respiratory tract irritation 14.05 13.28 4 29178 41 29545304
Decreased vibratory sense 14.01 13.28 7 29175 365 29544980
Polyneuropathy in malignant disease 13.96 13.28 5 29177 112 29545233
Urosepsis 13.96 13.28 32 29150 10714 29534631
Chills 13.94 13.28 119 29063 71181 29474164
Procedural pain 13.93 13.28 19 29163 4225 29541120
Abdominal distension 13.82 13.28 85 29097 45826 29499519
Cardiac disorder 13.76 13.28 10 29172 37253 29508092
Administration site discomfort 13.71 13.28 4 29178 45 29545300
Urine uric acid decreased 13.64 13.28 5 29177 120 29545225
Tracheal pain 13.63 13.28 4 29178 46 29545299
Anaemia of malignant disease 13.59 13.28 7 29175 389 29544956
Type I hypersensitivity 13.52 13.28 10 29172 1062 29544283
Urinary sediment abnormal 13.48 13.28 5 29177 124 29545221
Ureteric dilatation 13.37 13.28 5 29177 127 29545218
Bladder spasm 13.36 13.28 9 29173 824 29544521
Drug delivery device placement 13.33 13.28 5 29177 128 29545217
Bifascicular block 13.33 13.28 6 29176 247 29545098
Heart rate decreased 13.33 13.28 4 29178 24908 29520437

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 2441.91 12.11 1811 59700 202614 64234607
Product prescribing error 754.80 12.11 451 61060 34818 64402403
Haematochezia 424.03 12.11 412 61099 65961 64371260
Systemic infection 340.31 12.11 135 61376 4186 64433035
Anaemia 334.78 12.11 952 60559 377728 64059493
Agranulocytosis 289.61 12.11 261 61250 37968 64399253
Product monitoring error 280.93 12.11 126 61385 5328 64431893
Fracture 230.88 12.11 170 61341 18585 64418636
Drug ineffective 220.78 12.11 288 61223 839959 63597262
Pallor 173.08 12.11 199 61312 38582 64398639
Completed suicide 154.28 12.11 17 61494 224397 64212824
Leukopenia 141.57 12.11 304 61207 100938 64336283
Abdominal pain 139.89 12.11 629 60882 311746 64125475
Aspirin-exacerbated respiratory disease 137.88 12.11 49 61462 1111 64436110
Labelled drug-drug interaction medication error 133.38 12.11 133 61378 21929 64415292
Fall 130.48 12.11 759 60752 416067 64021154
Haematemesis 129.42 12.11 190 61321 46809 64390412
Polyneuropathy 122.25 12.11 121 61390 19773 64417448
Abdominal pain upper 118.70 12.11 402 61109 174628 64262593
Malaise 116.24 12.11 124 61387 396123 64041098
Vomiting 115.77 12.11 909 60602 550208 63887013
Joint swelling 114.15 12.11 32 61479 215350 64221871
Product administration error 113.60 12.11 136 61375 27507 64409714
Product dose omission issue 112.83 12.11 24 61487 194723 64242498
Musculoskeletal pain 112.36 12.11 243 61268 81051 64356170
Restlessness 109.77 12.11 161 61350 39624 64397597
Dyspnoea 109.61 12.11 1105 60406 717569 63719652
Electrolyte imbalance 106.71 12.11 126 61385 25117 64412104
Nausea 105.27 12.11 1177 60334 784623 63652598
Tachypnoea 96.73 12.11 123 61388 26448 64410773
Infusion related reaction 95.81 12.11 20 61491 164447 64272774
Abdominal discomfort 87.88 12.11 32 61479 182290 64254931
Cardiac failure congestive 86.94 12.11 11 61500 130569 64306652
Toxic epidermal necrolysis 86.48 12.11 139 61372 37027 64400194
Disturbance in attention 84.04 12.11 145 61366 40929 64396292
Tachycardia 83.89 12.11 323 61188 149256 64287965
Pyrexia 78.33 12.11 845 60666 557799 63879422
Treatment failure 77.38 12.11 10 61501 116806 64320415
Abdominal pain lower 77.21 12.11 110 61401 26359 64410862
Oedema peripheral 74.94 12.11 397 61114 209920 64227301
Synovitis 74.87 12.11 5 61506 99085 64338136
Therapeutic product effect decreased 71.50 12.11 12 61499 115339 64321882
Constipation 71.13 12.11 417 61094 228920 64208301
Sinusitis 69.66 12.11 26 61485 145902 64291319
Lower respiratory tract infection 68.03 12.11 6 61505 94608 64342613
Arthropathy 67.84 12.11 16 61495 120951 64316270
Jaundice 66.99 12.11 145 61366 48367 64388854
Erysipelas 66.76 12.11 61 61450 9020 64428201
Gamma-glutamyltransferase increased 64.72 12.11 143 61368 48367 64388854
Medication error 64.09 12.11 145 61366 49821 64387400
Injection site pain 63.94 12.11 14 61497 111394 64325827
Drug intolerance 63.05 12.11 52 61459 187940 64249281
Osteochondrosis 62.98 12.11 30 61481 1457 64435764
Death 61.84 12.11 244 61267 482461 63954760
Hepatorenal failure 60.11 12.11 27 61484 1145 64436076
Blood pressure increased 60.04 12.11 46 61465 172506 64264715
Swelling 59.29 12.11 40 61471 160178 64277043
Musculoskeletal stiffness 58.72 12.11 22 61489 123184 64314037
Drug-induced liver injury 58.61 12.11 136 61375 47507 64389714
Suspected product quality issue 58.45 12.11 18 61493 256 64436965
Apathy 57.59 12.11 62 61449 11170 64426051
Acute abdomen 57.46 12.11 35 61476 2789 64434432
Cachexia 56.51 12.11 56 61455 9161 64428060
Therapeutic drug monitoring analysis not performed 56.11 12.11 26 61485 1186 64436035
Dizziness 55.75 12.11 641 60870 429522 64007699
Malignant neoplasm progression 55.48 12.11 234 61277 112637 64324584
Lethargy 53.86 12.11 4 61507 72590 64364631
Haematoma 53.61 12.11 129 61382 46121 64391100
Drug hypersensitivity 50.15 12.11 94 61417 237721 64199500
Dyschezia 49.38 12.11 30 61481 2380 64434841
Nasal disorder 49.29 12.11 32 61479 2852 64434369
Myocardial infarction 48.40 12.11 52 61459 165769 64271452
Paresis 47.98 12.11 34 61477 3498 64433723
Suspected product contamination 46.85 12.11 12 61499 82 64437139
Feeling abnormal 45.98 12.11 36 61475 133566 64303655
Mucosal haemorrhage 45.72 12.11 28 61483 2253 64434968
Dehydration 45.51 12.11 358 61153 216405 64220816
Negative pressure pulmonary oedema 44.59 12.11 14 61497 213 64437008
Thirst 44.58 12.11 61 61450 14076 64423145
Nasopharyngitis 44.50 12.11 74 61437 195999 64241222
Toxicity to various agents 44.45 12.11 187 61324 363326 64073895
Interstitial lung disease 44.03 12.11 19 61492 97713 64339508
Subileus 43.74 12.11 37 61474 4940 64432281
Drug reaction with eosinophilia and systemic symptoms 43.47 12.11 132 61379 54085 64383136
Immobile 43.43 12.11 40 61471 5975 64431246
Pemphigus 43.22 12.11 4 61507 60697 64376524
Stevens-Johnson syndrome 40.20 12.11 96 61415 34153 64403068
Rheumatoid arthritis 40.14 12.11 59 61452 164235 64272986
Renal impairment 39.56 12.11 242 61269 134775 64302446
Tumour pain 39.44 12.11 24 61487 1909 64435312
Type I hypersensitivity 38.66 12.11 30 61481 3544 64433677
Systemic lupus erythematosus 38.44 12.11 13 61498 77599 64359622
Electrocardiogram abnormal 37.81 12.11 55 61456 13426 64423795
Arthralgia 37.68 12.11 257 61254 442003 63995218
Psoriasis 37.31 12.11 11 61500 71692 64365529
Dysuria 37.16 12.11 106 61405 41951 64395270
Wound 37.13 12.11 158 61353 76319 64360902
Drug interaction 36.40 12.11 515 60996 361568 64075653
Neuropathy peripheral 36.39 12.11 35 61476 117490 64319731
Urogenital haemorrhage 35.94 12.11 16 61495 664 64436557
Thrombocytopenia 35.71 12.11 348 61163 223453 64213768
Syncope 35.66 12.11 265 61246 157370 64279851
Pericarditis 35.57 12.11 8 61503 62508 64374713
Nasal congestion 35.25 12.11 7 61504 59651 64377570
Therapy non-responder 34.49 12.11 10 61501 65889 64371332
Flank pain 34.22 12.11 58 61453 16131 64421090
Maternal exposure during pregnancy 34.06 12.11 25 61486 95859 64341362
Respiratory arrest 33.98 12.11 5 61506 52980 64384241
Cellulitis 33.81 12.11 24 61487 93633 64343588
Blood pressure measurement 33.38 12.11 13 61498 383 64436838
Spinal pain 33.25 12.11 50 61461 12571 64424650
Platelet count decreased 33.00 12.11 69 61442 167642 64269579
Appendicolith 33.00 12.11 27 61484 3442 64433779
Acute hepatic failure 32.61 12.11 75 61436 26037 64411184
Hepatitis acute 32.41 12.11 51 61460 13338 64423883
Faecaloma 32.23 12.11 43 61468 9685 64427536
Urogenital infection bacterial 32.11 12.11 9 61502 90 64437131
Chills 31.75 12.11 232 61279 137032 64300189
Hospitalisation 31.75 12.11 16 61495 75191 64362030
Hypokalaemia 31.70 12.11 212 61299 121691 64315530
Alopecia 31.08 12.11 70 61441 165620 64271601
C-reactive protein increased 30.95 12.11 175 61336 94734 64342487
Angina pectoris 30.89 12.11 104 61407 44977 64392244
Platelet dysfunction 30.83 12.11 12 61499 353 64436868
Disease progression 30.74 12.11 55 61456 141625 64295596
Arrhythmia 30.19 12.11 115 61396 52829 64384392
Chronic fatigue syndrome 30.08 12.11 17 61494 1178 64436043
Listless 30.03 12.11 25 61486 3265 64433956
Abdominal distension 29.99 12.11 175 61336 95819 64341402
Heart rate increased 29.84 12.11 30 61481 98645 64338576
Injection site swelling 28.72 12.11 3 61508 41350 64395871
Injection site erythema 28.51 12.11 16 61495 70784 64366437
Febrile infection 28.48 12.11 23 61488 2878 64434343
Off label use 28.34 12.11 429 61082 632377 63804844
Bicytopenia 27.94 12.11 25 61486 3597 64433624
Reduced facial expression 27.92 12.11 20 61491 2093 64435128
Depressed level of consciousness 27.78 12.11 152 61359 81284 64355937
Ascites 27.74 12.11 125 61386 61876 64375345
Heart rate decreased 27.66 12.11 9 61502 55058 64382163
Neuromuscular block prolonged 27.62 12.11 15 61496 962 64436259
Unresponsive to stimuli 27.59 12.11 7 61504 50386 64386835
Pancytopenia 27.51 12.11 232 61279 143077 64294144
Cardio-respiratory arrest 27.44 12.11 32 61479 98361 64338860
Therapeutic product effect incomplete 27.44 12.11 35 61476 103447 64333774
Product use issue 26.93 12.11 66 61445 151649 64285572
Bradycardia 26.87 12.11 199 61312 118020 64319201
Micturition disorder 26.84 12.11 23 61488 3125 64434096
Facial nerve disorder 26.79 12.11 13 61498 658 64436563
Hypoaesthesia 26.72 12.11 58 61453 139050 64298171
Gastritis erosive 26.70 12.11 39 61472 9556 64427665
Accessory spleen 26.57 12.11 9 61502 176 64437045
Orthostatic hypotension 26.55 12.11 6 61505 46732 64390489
Contusion 25.85 12.11 43 61468 113922 64323299
Angioedema 25.71 12.11 122 61389 61699 64375522
Fluid intake reduced 25.43 12.11 28 61483 5172 64432049
Gastrointestinal disorder 25.21 12.11 29 61482 89680 64347541
Vertigo 24.94 12.11 117 61394 58894 64378327
Hypersensitivity 24.63 12.11 100 61411 196352 64240869
Haemorrhagic necrotic pancreatitis 24.62 12.11 7 61504 74 64437147
Disorientation 24.56 12.11 112 61399 55716 64381505
Hydrocholecystis 24.28 12.11 10 61501 342 64436879
Nail toxicity 24.17 12.11 10 61501 346 64436875
Long QT syndrome 23.98 12.11 27 61484 5112 64432109
Helicobacter infection 23.74 12.11 4 61507 38358 64398863
Hepatitis cholestatic 23.67 12.11 42 61469 12113 64425108
Decreased appetite 23.57 12.11 388 61123 280901 64156320
Blood pressure fluctuation 23.49 12.11 10 61501 51861 64385360
Flatulence 23.31 12.11 81 61430 35585 64401636
Rash 23.28 12.11 303 61208 458246 63978975
Drug resistance 23.25 12.11 3 61508 35099 64402122
Thirst decreased 23.12 12.11 9 61502 265 64436956
Loss of personal independence in daily activities 23.11 12.11 21 61490 72433 64364788
Upper gastrointestinal haemorrhage 23.03 12.11 80 61431 35140 64402081
Gallbladder polyp 23.03 12.11 13 61498 899 64436322
Post-traumatic pain 22.95 12.11 10 61501 394 64436827
Cardiac arrest 22.91 12.11 73 61438 153991 64283230
Delirium 22.83 12.11 128 61383 69066 64368155
Psychotic disorder 22.79 12.11 3 61508 34575 64402646
Migraine 22.70 12.11 16 61495 62661 64374560
Flushing 22.56 12.11 25 61486 78623 64358598
Unevaluable event 22.45 12.11 10 61501 50479 64386742
Drug abuse 22.40 12.11 59 61452 132315 64304906
Therapeutic response decreased 22.18 12.11 11 61500 52177 64385044
Haematuria 22.07 12.11 115 61396 60356 64376865
Adverse drug reaction 21.85 12.11 8 61503 45456 64391765
Dysdiadochokinesis 21.84 12.11 9 61502 308 64436913
Discomfort 21.81 12.11 27 61484 80851 64356370
Weight increased 21.79 12.11 117 61394 213231 64223990
Tension headache 21.57 12.11 21 61490 3362 64433859
Product used for unknown indication 21.42 12.11 12 61499 818 64436403
Muscle tone disorder 21.25 12.11 7 61504 125 64437096
Blood folate increased 21.20 12.11 10 61501 475 64436746
Injection site reaction 21.13 12.11 9 61502 46655 64390566
Coombs negative haemolytic anaemia 20.84 12.11 9 61502 347 64436874
Urosepsis 20.81 12.11 57 61454 22037 64415184
Hyperventilation 20.79 12.11 29 61482 6811 64430410
Cerebrovascular accident 20.59 12.11 65 61446 137518 64299703
Cardiac disorder 20.55 12.11 14 61497 55802 64381419
Acute generalised exanthematous pustulosis 20.53 12.11 43 61468 14015 64423206
Hepatitis toxic 20.33 12.11 23 61488 4377 64432844
Blood pressure decreased 20.04 12.11 32 61479 86167 64351054
Pelvic fracture 19.93 12.11 36 61475 10527 64426694
Oropharyngeal discomfort 19.89 12.11 25 61486 5310 64431911
Vascular encephalopathy 19.63 12.11 10 61501 562 64436659
Peripheral swelling 19.57 12.11 118 61393 209035 64228186
Pseudarthrosis 19.47 12.11 8 61503 272 64436949
Pulmonary sepsis 19.44 12.11 19 61492 3056 64434165
Depression 19.00 12.11 100 61411 183191 64254030
Irritable bowel syndrome 18.96 12.11 6 61505 37363 64399858
Hepatic function abnormal 18.94 12.11 20 61491 64293 64372928
Folliculitis 18.92 12.11 3 61508 30074 64407147
Pneumobilia 18.69 12.11 7 61504 185 64437036
Duodenal ulcer 18.62 12.11 42 61469 14393 64422828
Gastrointestinal sounds abnormal 18.55 12.11 23 61488 4820 64432401
Localised infection 18.43 12.11 67 61444 30094 64407127
Fluid retention 18.16 12.11 18 61493 59588 64377633
Inappropriate schedule of product administration 18.12 12.11 38 61473 92248 64344973
Disease recurrence 17.99 12.11 4 61507 31506 64405715
Anaemia of malignant disease 17.98 12.11 10 61501 672 64436549
Peripheral circulatory failure 17.86 12.11 10 61501 681 64436540
Multiple organ dysfunction syndrome 17.80 12.11 161 61350 101252 64335969
Hyponatraemia 17.78 12.11 218 61293 148121 64289100
Hyperglycaemia 17.66 12.11 109 61402 60859 64376362
Fibromyalgia 17.66 12.11 6 61505 35725 64401496
Weight bearing difficulty 17.65 12.11 17 61494 2686 64434535
Implant site inflammation 17.61 12.11 7 61504 218 64437003
Medication overuse headache 17.60 12.11 10 61501 700 64436521
White blood cell count decreased 17.56 12.11 84 61427 157753 64279468
Hypoxia 17.55 12.11 36 61475 88113 64349108
Ileus 17.55 12.11 55 61456 22911 64414310
Product packaging confusion 17.43 12.11 7 61504 224 64436997
Paraparesis 17.37 12.11 19 61492 3483 64433738
Wrong technique in product usage process 17.20 12.11 22 61489 64952 64372269
Head injury 17.15 12.11 5 61506 32837 64404384
Hepatic cyst 17.11 12.11 23 61488 5217 64432004
Psoriatic arthropathy 17.11 12.11 10 61501 43271 64393950
Lividity 17.04 12.11 8 61503 376 64436845
Exposure during pregnancy 16.98 12.11 30 61481 77645 64359576
Gastritis 16.92 12.11 83 61428 42535 64394686
Rash pruritic 16.73 12.11 18 61493 57386 64379835
Antineutrophil cytoplasmic antibody positive 16.73 12.11 11 61500 1001 64436220
Tonsillitis 16.69 12.11 24 61487 5796 64431425
Product prescribing issue 16.60 12.11 15 61496 2186 64435035
Full blood count abnormal 16.55 12.11 4 61507 29753 64407468
Spinal cord injury cauda equina 16.48 12.11 6 61505 146 64437075
Vasculitis 16.36 12.11 46 61465 18049 64419172
Type 2 diabetes mellitus 16.32 12.11 6 61505 34014 64403207
Knee arthroplasty 16.30 12.11 3 61508 26996 64410225
Hypertensive crisis 16.12 12.11 46 61465 18202 64419019
International normalised ratio increased 16.05 12.11 32 61479 79135 64358086
Appendicitis 15.88 12.11 38 61473 13531 64423690
Vitamin B6 deficiency 15.87 12.11 7 61504 284 64436937
Breath sounds normal 15.79 12.11 3 61508 3 64437218
Respiratory alkalosis 15.72 12.11 19 61492 3878 64433343
Seizure 15.69 12.11 94 61417 166798 64270423
Pulmonary hypertension 15.64 12.11 11 61500 43128 64394093
Cardiac failure 15.63 12.11 194 61317 132179 64305042
Peritoneal perforation 15.63 12.11 6 61505 170 64437051
Prescribed underdose 15.52 12.11 45 61466 17970 64419251
Hepatic failure 15.40 12.11 98 61413 55296 64381925
Amnesia 15.38 12.11 14 61497 48255 64388966
Haemorrhagic erosive gastritis 15.38 12.11 8 61503 470 64436751
Necrotising fasciitis 15.33 12.11 22 61489 5304 64431917
Somatosensory evoked potentials abnormal 15.27 12.11 6 61505 181 64437040
Product impurity 15.25 12.11 5 61506 88 64437133
Agitation 15.24 12.11 39 61472 88328 64348893
Oliguria 15.14 12.11 39 61472 14537 64422684
Lordosis 15.05 12.11 7 61504 322 64436899
Hypervolaemia 14.91 12.11 9 61502 38276 64398945
Conjunctivitis 14.88 12.11 48 61463 20306 64416915
Head discomfort 14.79 12.11 34 61477 11800 64425421
Preternatural anus 14.65 12.11 5 61506 100 64437121
Hepatocellular injury 14.55 12.11 13 61498 45222 64391999
Mycobacterium fortuitum infection 14.55 12.11 6 61505 206 64437015
Cross sensitivity reaction 14.55 12.11 17 61494 3350 64433871
Prescription drug used without a prescription 14.48 12.11 15 61496 2585 64434636
Subacute hepatic failure 14.46 12.11 6 61505 209 64437012
Visual acuity reduced 14.42 12.11 4 61507 27137 64410084
Cardiac murmur functional 14.36 12.11 4 61507 39 64437182
Toxic neuropathy 14.02 12.11 9 61502 787 64436434
Hyperaemia 13.97 12.11 15 61496 2694 64434527
Solar dermatitis 13.95 12.11 6 61505 229 64436992
Urine uric acid decreased 13.80 12.11 5 61506 120 64437101
Bulimia nervosa 13.78 12.11 6 61505 236 64436985
Ill-defined disorder 13.77 12.11 13 61498 44039 64393182
Tracheal pain 13.77 12.11 4 61507 46 64437175
VIIIth nerve injury 13.72 12.11 3 61508 9 64437212
Necrolytic migratory erythema 13.72 12.11 3 61508 9 64437212
Anaemia folate deficiency 13.59 12.11 6 61505 244 64436977
Reactive gastropathy 13.43 12.11 7 61504 413 64436808
Anxiety 13.40 12.11 126 61385 202523 64234698
Lumbar vertebral fracture 13.37 12.11 21 61490 5481 64431740
Pulmonary vein occlusion 13.35 12.11 5 61506 132 64437089
Intestinal haemorrhage 13.34 12.11 21 61490 5493 64431728
Headache 13.29 12.11 394 61117 529073 63908148
Sensory level abnormal 13.28 12.11 5 61506 134 64437087
Skin irritation 13.28 12.11 28 61483 9166 64428055
Genitourinary tract infection 13.28 12.11 6 61505 258 64436963
Spontaneous haemorrhage 13.18 12.11 7 61504 429 64436792
Concomitant disease aggravated 13.16 12.11 32 61479 11510 64425711
Adverse event 13.13 12.11 11 61500 39478 64397743
Oedematous pancreatitis 13.12 12.11 9 61502 879 64436342
Laryngeal oedema 13.11 12.11 24 61487 7089 64430132
Food interaction 13.09 12.11 11 61500 1455 64435766
Transaminases increased 13.09 12.11 80 61431 44514 64392707
Urinary sediment abnormal 13.08 12.11 5 61506 140 64437081
Confusional state 13.06 12.11 173 61338 260971 64176250
Leptotrichia infection 13.05 12.11 4 61507 56 64437165
Stenosis 12.97 12.11 12 61499 1803 64435418
Fear of disease 12.96 12.11 9 61502 896 64436325
Hyperkinesia 12.96 12.11 14 61497 2532 64434689
Wrong product administered 12.93 12.11 25 61486 7695 64429526
Colitis 12.89 12.11 98 61413 58576 64378645
Oral candidiasis 12.88 12.11 50 61461 23162 64414059
Adrenocortical insufficiency acute 12.87 12.11 14 61497 2551 64434670
Organic brain syndrome 12.86 12.11 7 61504 451 64436770
Mucosal dryness 12.71 12.11 15 61496 2986 64434235
Lack of application site rotation 12.68 12.11 3 61508 14 64437207
Gastric disorder 12.64 12.11 6 61505 29191 64408030
Polyneuropathy in malignant disease 12.60 12.11 5 61506 155 64437066
Alpha 2 globulin increased 12.60 12.11 5 61506 155 64437066
Rhabdomyolysis 12.58 12.11 45 61466 91681 64345540
Pure white cell aplasia 12.55 12.11 4 61507 64 64437157
Brain contusion 12.54 12.11 10 61501 1229 64435992
Tumour haemorrhage 12.44 12.11 16 61495 3477 64433744
Non-small cell lung cancer 12.35 12.11 19 61492 4871 64432350
Arthritis 12.25 12.11 40 61471 83774 64353447
Peripheral arterial occlusive disease 12.16 12.11 23 61488 6964 64430257
Ureteric dilatation 12.14 12.11 5 61506 171 64437050
Paraplegia 12.13 12.11 18 61493 4472 64432749

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BB02 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB52 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB72 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D058633 Antipyretics
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:49110 peripheral nervous system drugs
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:73263 cyclooxygenase-3 inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Zimeta Kindred Biosciences Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.21 acidic
pKa2 5.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Transient receptor potential cation channel subfamily A member 1 Ion channel BLOCKER IC50 4.04 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D08190 KEGG_DRUG
N0000167060 NUI
5907-38-0 SECONDARY_CAS_RN
CHEBI:59033 CHEBI
CHEMBL3989803 ChEMBL_ID
C024864 MESH_SUPPLEMENTAL_RECORD_UI
10608 IUPHAR_LIGAND_ID
6150-97-6 SECONDARY_CAS_RN
51996-59-9 SECONDARY_CAS_RN
DB04817 DRUGBANK_ID
934T64RMNJ UNII
3111 PUBCHEM_CID
1537943 RXNORM
NOCODE MMSL
001609 NDDF
006029 NDDF
22165008 SNOMEDCT_US
735071007 SNOMEDCT_US
780831000 SNOMEDCT_US
781025005 SNOMEDCT_US
D004177 MESH_DESCRIPTOR_UI
C0012586 UMLSCUI
CHEMBL461522 ChEMBL_ID
477 INN_ID
50567-35-6 SECONDARY_CAS_RN

Pharmaceutical products:

None