Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory analgesics, phenylbutazone derivatives | 4659 | 68-89-3 |
Dose | Unit | Route |
---|---|---|
3 | g | O |
3 | g | P |
3 | g | R |
None
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 1257.61 | 12.35 | 967 | 37974 | 141467 | 50424716 |
Product prescribing error | 490.88 | 12.35 | 264 | 38677 | 20697 | 50545486 |
Haematochezia | 297.31 | 12.35 | 246 | 38695 | 39636 | 50526547 |
Agranulocytosis | 267.13 | 12.35 | 180 | 38761 | 21241 | 50544942 |
Anaemia | 217.23 | 12.35 | 549 | 38392 | 251907 | 50314276 |
Product monitoring error | 208.77 | 12.35 | 79 | 38862 | 2685 | 50563498 |
Drug ineffective | 191.91 | 12.35 | 210 | 38731 | 819123 | 49747060 |
Fracture | 185.25 | 12.35 | 131 | 38810 | 16702 | 50549481 |
Systemic infection | 178.77 | 12.35 | 67 | 38874 | 2216 | 50563967 |
Polyneuropathy | 146.58 | 12.35 | 100 | 38841 | 12031 | 50554152 |
Haematemesis | 133.72 | 12.35 | 134 | 38807 | 27591 | 50538592 |
Aspirin-exacerbated respiratory disease | 132.34 | 12.35 | 42 | 38899 | 832 | 50565351 |
Fall | 123.45 | 12.35 | 547 | 38394 | 334385 | 50231798 |
Joint swelling | 113.56 | 12.35 | 25 | 38916 | 245261 | 50320922 |
Product dose omission issue | 105.19 | 12.35 | 10 | 38931 | 183828 | 50382355 |
Abdominal pain lower | 97.35 | 12.35 | 101 | 38840 | 21655 | 50544528 |
Leukopenia | 95.81 | 12.35 | 180 | 38761 | 67348 | 50498835 |
Pallor | 91.98 | 12.35 | 101 | 38840 | 23098 | 50543085 |
Labelled drug-drug interaction medication error | 91.57 | 12.35 | 71 | 38870 | 10406 | 50555777 |
Abdominal discomfort | 86.54 | 12.35 | 35 | 38906 | 231606 | 50334577 |
Systemic lupus erythematosus | 84.99 | 12.35 | 6 | 38935 | 140616 | 50425567 |
Product administration error | 83.77 | 12.35 | 89 | 38852 | 19610 | 50546573 |
Infusion related reaction | 83.20 | 12.35 | 15 | 38926 | 169542 | 50396641 |
Synovitis | 82.05 | 12.35 | 3 | 38938 | 123862 | 50442321 |
Apathy | 81.31 | 12.35 | 58 | 38883 | 7490 | 50558693 |
Abdominal pain | 78.81 | 12.35 | 375 | 38566 | 235853 | 50330330 |
Toxic epidermal necrolysis | 77.40 | 12.35 | 88 | 38853 | 20904 | 50545279 |
Treatment failure | 77.37 | 12.35 | 8 | 38933 | 137629 | 50428554 |
Restlessness | 77.10 | 12.35 | 96 | 38845 | 25077 | 50541106 |
Pemphigus | 76.01 | 12.35 | 4 | 38937 | 120162 | 50446021 |
Dyspnoea | 74.60 | 12.35 | 694 | 38247 | 546914 | 50019269 |
Stevens-Johnson syndrome | 73.20 | 12.35 | 87 | 38854 | 21665 | 50544518 |
Erysipelas | 71.70 | 12.35 | 51 | 38890 | 6557 | 50559626 |
Therapeutic product effect decreased | 69.02 | 12.35 | 11 | 38930 | 136039 | 50430144 |
Vomiting | 68.86 | 12.35 | 596 | 38345 | 460162 | 50106021 |
Drug-induced liver injury | 68.80 | 12.35 | 96 | 38845 | 27999 | 50538184 |
Sinusitis | 68.34 | 12.35 | 23 | 38918 | 170535 | 50395648 |
Drug intolerance | 65.70 | 12.35 | 44 | 38897 | 219060 | 50347123 |
Swelling | 64.85 | 12.35 | 37 | 38904 | 200835 | 50365348 |
Drug hypersensitivity | 64.42 | 12.35 | 59 | 38882 | 250951 | 50315232 |
Abdominal pain upper | 61.36 | 12.35 | 264 | 38677 | 159045 | 50407138 |
Nausea | 61.26 | 12.35 | 818 | 38123 | 704580 | 49861603 |
Arrhythmia | 59.52 | 12.35 | 98 | 38843 | 33034 | 50533149 |
Arthropathy | 58.71 | 12.35 | 24 | 38917 | 157882 | 50408301 |
Tachypnoea | 58.71 | 12.35 | 64 | 38877 | 14513 | 50551670 |
Completed suicide | 57.91 | 12.35 | 15 | 38926 | 131874 | 50434309 |
Jaundice | 55.53 | 12.35 | 84 | 38857 | 26345 | 50539838 |
Lower respiratory tract infection | 54.90 | 12.35 | 5 | 38936 | 95196 | 50470987 |
Malaise | 54.62 | 12.35 | 110 | 38831 | 335422 | 50230761 |
Electrolyte imbalance | 53.41 | 12.35 | 66 | 38875 | 17103 | 50549080 |
Alopecia | 51.40 | 12.35 | 68 | 38873 | 244979 | 50321204 |
Drug interaction | 51.37 | 12.35 | 295 | 38646 | 199326 | 50366857 |
Rheumatoid arthritis | 49.16 | 12.35 | 50 | 38891 | 202500 | 50363683 |
Pericarditis | 48.58 | 12.35 | 3 | 38938 | 78686 | 50487497 |
Haematoma | 47.89 | 12.35 | 85 | 38856 | 30425 | 50535758 |
Pyrexia | 47.70 | 12.35 | 474 | 38467 | 379729 | 50186454 |
Osteochondrosis | 47.40 | 12.35 | 21 | 38920 | 1073 | 50565110 |
Pancytopenia | 46.16 | 12.35 | 156 | 38785 | 83874 | 50482309 |
Gamma-glutamyltransferase increased | 45.81 | 12.35 | 82 | 38859 | 29541 | 50536642 |
Nasal disorder | 45.56 | 12.35 | 26 | 38915 | 2282 | 50563901 |
Maternal exposure during pregnancy | 45.35 | 12.35 | 34 | 38907 | 159744 | 50406439 |
Disturbance in attention | 45.28 | 12.35 | 84 | 38857 | 31102 | 50535081 |
Tachycardia | 44.45 | 12.35 | 173 | 38768 | 99590 | 50466593 |
Malignant neoplasm progression | 44.27 | 12.35 | 134 | 38807 | 67990 | 50498193 |
Stenosis | 42.71 | 12.35 | 20 | 38921 | 1163 | 50565020 |
Hepatorenal failure | 41.11 | 12.35 | 16 | 38925 | 587 | 50565596 |
Oedema peripheral | 40.98 | 12.35 | 234 | 38707 | 157727 | 50408456 |
Reduced facial expression | 39.88 | 12.35 | 21 | 38920 | 1573 | 50564610 |
Syncope | 39.86 | 12.35 | 171 | 38770 | 102831 | 50463352 |
Acute hepatic failure | 39.02 | 12.35 | 54 | 38887 | 15623 | 50550560 |
Medication error | 39.00 | 12.35 | 86 | 38855 | 36018 | 50530165 |
Nasopharyngitis | 38.96 | 12.35 | 55 | 38886 | 192872 | 50373311 |
Product use issue | 38.46 | 12.35 | 35 | 38906 | 149440 | 50416743 |
Musculoskeletal stiffness | 38.21 | 12.35 | 26 | 38915 | 128455 | 50437728 |
Arthralgia | 37.51 | 12.35 | 192 | 38749 | 438510 | 50127673 |
Ascites | 37.14 | 12.35 | 84 | 38857 | 35777 | 50530406 |
Listless | 36.95 | 12.35 | 23 | 38918 | 2367 | 50563816 |
Cardiac failure | 36.45 | 12.35 | 135 | 38806 | 75905 | 50490278 |
Injection site pain | 36.45 | 12.35 | 20 | 38921 | 111004 | 50455179 |
Subileus | 36.33 | 12.35 | 24 | 38917 | 2735 | 50563448 |
Hypokalaemia | 36.31 | 12.35 | 149 | 38792 | 87843 | 50478340 |
Cardiac failure congestive | 36.26 | 12.35 | 10 | 38931 | 84372 | 50481811 |
Renal impairment | 36.00 | 12.35 | 134 | 38807 | 75527 | 50490656 |
Somatic symptom disorder | 35.98 | 12.35 | 21 | 38920 | 1923 | 50564260 |
Tumour pain | 35.97 | 12.35 | 18 | 38923 | 1212 | 50564971 |
Hepatitis toxic | 35.89 | 12.35 | 24 | 38917 | 2792 | 50563391 |
Suspected product quality issue | 35.85 | 12.35 | 11 | 38930 | 194 | 50565989 |
Musculoskeletal pain | 35.32 | 12.35 | 129 | 38812 | 72048 | 50494135 |
Concomitant disease aggravated | 35.18 | 12.35 | 37 | 38904 | 8054 | 50558129 |
Gallbladder polyp | 35.02 | 12.35 | 15 | 38926 | 706 | 50565477 |
Rash | 34.34 | 12.35 | 197 | 38744 | 437274 | 50128909 |
Constipation | 34.01 | 12.35 | 252 | 38689 | 185456 | 50380727 |
Urogenital haemorrhage | 33.97 | 12.35 | 11 | 38930 | 233 | 50565950 |
Atrial fibrillation | 33.45 | 12.35 | 161 | 38780 | 101584 | 50464599 |
Dysuria | 33.20 | 12.35 | 70 | 38871 | 28434 | 50537749 |
Dehydration | 32.68 | 12.35 | 215 | 38726 | 152234 | 50413949 |
Dizziness | 32.08 | 12.35 | 407 | 38534 | 345962 | 50220221 |
Therapeutic drug monitoring analysis not performed | 32.05 | 12.35 | 14 | 38927 | 691 | 50565492 |
Facial nerve disorder | 32.04 | 12.35 | 13 | 38928 | 533 | 50565650 |
Type I hypersensitivity | 32.02 | 12.35 | 21 | 38920 | 2364 | 50563819 |
Angina pectoris | 31.30 | 12.35 | 65 | 38876 | 26123 | 50540060 |
Weight increased | 31.27 | 12.35 | 68 | 38873 | 201823 | 50364360 |
Spinal pain | 31.17 | 12.35 | 40 | 38901 | 10763 | 50555420 |
Bicytopenia | 30.86 | 12.35 | 19 | 38922 | 1917 | 50564266 |
Gastrointestinal sounds abnormal | 30.40 | 12.35 | 24 | 38917 | 3610 | 50562573 |
Headache | 29.00 | 12.35 | 250 | 38691 | 506285 | 50059898 |
Nasal congestion | 28.63 | 12.35 | 3 | 38938 | 51117 | 50515066 |
Respiratory alkalosis | 28.62 | 12.35 | 20 | 38921 | 2499 | 50563684 |
Contraindicated product administered | 28.56 | 12.35 | 44 | 38897 | 148914 | 50417269 |
Thrombocytopenia | 28.55 | 12.35 | 182 | 38759 | 127491 | 50438692 |
Thirst | 28.50 | 12.35 | 38 | 38903 | 10612 | 50555571 |
Injection site erythema | 28.47 | 12.35 | 11 | 38930 | 74925 | 50491258 |
Faecaloma | 28.26 | 12.35 | 31 | 38910 | 7077 | 50559106 |
Therapeutic product effect incomplete | 27.90 | 12.35 | 18 | 38923 | 91497 | 50474686 |
Cachexia | 27.73 | 12.35 | 25 | 38916 | 4508 | 50561675 |
Delirium | 27.55 | 12.35 | 78 | 38863 | 38114 | 50528069 |
Muscle tone disorder | 27.09 | 12.35 | 8 | 38933 | 123 | 50566060 |
Upper gastrointestinal haemorrhage | 26.88 | 12.35 | 46 | 38895 | 15989 | 50550194 |
Nail toxicity | 26.70 | 12.35 | 10 | 38931 | 330 | 50565853 |
Antineutrophil cytoplasmic antibody positive | 26.04 | 12.35 | 11 | 38930 | 500 | 50565683 |
Discomfort | 25.99 | 12.35 | 27 | 38914 | 108353 | 50457830 |
Post-traumatic pain | 25.72 | 12.35 | 10 | 38931 | 366 | 50565817 |
Thirst decreased | 25.66 | 12.35 | 9 | 38932 | 245 | 50565938 |
Acute generalised exanthematous pustulosis | 25.64 | 12.35 | 33 | 38908 | 8905 | 50557278 |
Drug reaction with eosinophilia and systemic symptoms | 25.54 | 12.35 | 63 | 38878 | 28361 | 50537822 |
Immobile | 25.41 | 12.35 | 25 | 38916 | 5029 | 50561154 |
Prescription drug used without a prescription | 25.37 | 12.35 | 16 | 38925 | 1684 | 50564499 |
Vascular encephalopathy | 25.36 | 12.35 | 10 | 38931 | 380 | 50565803 |
Hepatic failure | 25.34 | 12.35 | 68 | 38873 | 32215 | 50533968 |
Helicobacter infection | 25.23 | 12.35 | 4 | 38937 | 49698 | 50516485 |
Ileus | 24.93 | 12.35 | 40 | 38901 | 13189 | 50552994 |
Pseudarthrosis | 24.81 | 12.35 | 10 | 38931 | 403 | 50565780 |
Psoriasis | 24.80 | 12.35 | 11 | 38930 | 68989 | 50497194 |
Pelvic fracture | 24.74 | 12.35 | 37 | 38904 | 11483 | 50554700 |
Hypersensitivity | 24.65 | 12.35 | 84 | 38857 | 215077 | 50351106 |
Insomnia | 24.59 | 12.35 | 62 | 38879 | 174803 | 50391380 |
Hospitalisation | 24.15 | 12.35 | 11 | 38930 | 67926 | 50498257 |
Hepatitis acute | 23.79 | 12.35 | 30 | 38911 | 7931 | 50558252 |
Acute kidney injury | 23.69 | 12.35 | 274 | 38667 | 227784 | 50338399 |
Urinary retention | 23.48 | 12.35 | 58 | 38883 | 26132 | 50540051 |
Localised infection | 23.45 | 12.35 | 57 | 38884 | 25428 | 50540755 |
Chromaturia | 23.34 | 12.35 | 41 | 38900 | 14549 | 50551634 |
Vasculitis | 23.28 | 12.35 | 40 | 38901 | 13951 | 50552232 |
Blood pressure increased | 23.04 | 12.35 | 42 | 38899 | 133090 | 50433093 |
Lividity | 22.74 | 12.35 | 8 | 38933 | 220 | 50565963 |
Device stimulation issue | 22.51 | 12.35 | 6 | 38935 | 62 | 50566121 |
Heart rate increased | 22.47 | 12.35 | 16 | 38925 | 77234 | 50488949 |
Feeling abnormal | 22.25 | 12.35 | 39 | 38902 | 125453 | 50440730 |
Psychotic symptom | 22.19 | 12.35 | 13 | 38928 | 1199 | 50564984 |
Gastric ulcer | 22.16 | 12.35 | 50 | 38891 | 21255 | 50544928 |
Death | 22.14 | 12.35 | 153 | 38788 | 325226 | 50240957 |
Therapy non-responder | 22.01 | 12.35 | 6 | 38935 | 51016 | 50515167 |
Suspected product contamination | 21.91 | 12.35 | 5 | 38936 | 25 | 50566158 |
Peripheral circulatory failure | 21.84 | 12.35 | 10 | 38931 | 552 | 50565631 |
Head discomfort | 21.71 | 12.35 | 34 | 38907 | 10985 | 50555198 |
Gastritis erosive | 21.47 | 12.35 | 23 | 38918 | 5111 | 50561072 |
Aortic valve stenosis | 21.41 | 12.35 | 18 | 38923 | 2957 | 50563226 |
Injection site reaction | 21.36 | 12.35 | 6 | 38935 | 50026 | 50516157 |
Paranasal sinus inflammation | 21.33 | 12.35 | 9 | 38932 | 408 | 50565775 |
Hypoaesthesia | 21.27 | 12.35 | 41 | 38900 | 127216 | 50438967 |
Injection site pruritus | 21.09 | 12.35 | 3 | 38938 | 40408 | 50525775 |
Haemorrhagic erosive gastritis | 21.08 | 12.35 | 8 | 38933 | 274 | 50565909 |
Gastrointestinal disorder | 21.03 | 12.35 | 25 | 38916 | 94431 | 50471752 |
Lethargy | 20.97 | 12.35 | 6 | 38935 | 49426 | 50516757 |
Medication overuse headache | 20.68 | 12.35 | 10 | 38931 | 625 | 50565558 |
Fluid intake reduced | 20.66 | 12.35 | 18 | 38923 | 3104 | 50563079 |
Bradycardia | 20.48 | 12.35 | 101 | 38840 | 64325 | 50501858 |
Myocardial infarction | 20.43 | 12.35 | 23 | 38918 | 89004 | 50477179 |
Gastroenteritis | 20.29 | 12.35 | 51 | 38890 | 23230 | 50542953 |
Coombs negative haemolytic anaemia | 20.05 | 12.35 | 7 | 38934 | 188 | 50565995 |
Vertigo | 19.99 | 12.35 | 86 | 38855 | 51746 | 50514437 |
Acute abdomen | 19.99 | 12.35 | 13 | 38928 | 1443 | 50564740 |
Off label use | 19.83 | 12.35 | 252 | 38689 | 474174 | 50092009 |
Therapeutic response decreased | 19.55 | 12.35 | 6 | 38935 | 47225 | 50518958 |
Necrotising fasciitis | 19.25 | 12.35 | 16 | 38925 | 2588 | 50563595 |
Sensory level abnormal | 19.19 | 12.35 | 6 | 38935 | 113 | 50566070 |
Left ventricular hypertrophy | 19.03 | 12.35 | 21 | 38920 | 4824 | 50561359 |
Pneumobilia | 18.99 | 12.35 | 6 | 38935 | 117 | 50566066 |
Peritoneal perforation | 18.85 | 12.35 | 6 | 38935 | 120 | 50566063 |
Unevaluable event | 18.80 | 12.35 | 6 | 38935 | 46060 | 50520123 |
Foreign body | 18.63 | 12.35 | 14 | 38927 | 1957 | 50564226 |
Oliguria | 18.53 | 12.35 | 27 | 38914 | 8189 | 50557994 |
Fluid retention | 18.32 | 12.35 | 8 | 38933 | 50641 | 50515542 |
Stoma site inflammation | 18.24 | 12.35 | 8 | 38933 | 399 | 50565784 |
Amnesia | 18.17 | 12.35 | 5 | 38936 | 42255 | 50523928 |
Nail avulsion | 18.06 | 12.35 | 6 | 38935 | 138 | 50566045 |
Conjunctivitis | 18.05 | 12.35 | 39 | 38902 | 16106 | 50550077 |
Knee arthroplasty | 17.94 | 12.35 | 3 | 38938 | 35843 | 50530340 |
Affective disorder | 17.88 | 12.35 | 21 | 38920 | 5160 | 50561023 |
Spontaneous haemorrhage | 17.85 | 12.35 | 7 | 38934 | 262 | 50565921 |
Patent ductus arteriosus | 17.56 | 12.35 | 18 | 38923 | 3802 | 50562381 |
Flank pain | 17.40 | 12.35 | 34 | 38907 | 13081 | 50553102 |
Sensory disturbance | 17.34 | 12.35 | 32 | 38909 | 11797 | 50554386 |
Faeces pale | 17.32 | 12.35 | 12 | 38929 | 1479 | 50564704 |
Injury | 17.27 | 12.35 | 8 | 38933 | 48917 | 50517266 |
Liver function test increased | 17.22 | 12.35 | 51 | 38890 | 25555 | 50540628 |
Neuropathy peripheral | 17.21 | 12.35 | 30 | 38911 | 96727 | 50469456 |
Diverticulum intestinal | 17.17 | 12.35 | 22 | 38919 | 5911 | 50560272 |
Internal haemorrhage | 17.10 | 12.35 | 19 | 38922 | 4398 | 50561785 |
Gastritis | 17.02 | 12.35 | 60 | 38881 | 32923 | 50533260 |
Peripheral arterial occlusive disease | 16.87 | 12.35 | 17 | 38924 | 3520 | 50562663 |
Decreased appetite | 16.84 | 12.35 | 232 | 38709 | 200691 | 50365492 |
Urogenital infection bacterial | 16.51 | 12.35 | 4 | 38937 | 27 | 50566156 |
Lumbar vertebral fracture | 16.48 | 12.35 | 19 | 38922 | 4578 | 50561605 |
Anaemia folate deficiency | 16.47 | 12.35 | 6 | 38935 | 183 | 50566000 |
Merycism | 16.40 | 12.35 | 6 | 38935 | 185 | 50565998 |
No adverse event | 16.39 | 12.35 | 3 | 38938 | 33575 | 50532608 |
Painful respiration | 16.33 | 12.35 | 14 | 38927 | 2361 | 50563822 |
Ill-defined disorder | 16.32 | 12.35 | 11 | 38930 | 54643 | 50511540 |
Heart rate decreased | 16.30 | 12.35 | 4 | 38937 | 36493 | 50529690 |
Haematuria | 16.27 | 12.35 | 50 | 38891 | 25563 | 50540620 |
Cancer fatigue | 16.15 | 12.35 | 4 | 38937 | 30 | 50566153 |
Hyperglycaemia | 16.09 | 12.35 | 63 | 38878 | 36342 | 50529841 |
Brain contusion | 16.05 | 12.35 | 8 | 38933 | 534 | 50565649 |
Urinary tract infection enterococcal | 16.04 | 12.35 | 14 | 38927 | 2420 | 50563763 |
Inappropriate schedule of product administration | 16.00 | 12.35 | 19 | 38922 | 71812 | 50494371 |
Peripheral swelling | 15.96 | 12.35 | 93 | 38848 | 205843 | 50360340 |
Chills | 15.89 | 12.35 | 128 | 38813 | 96559 | 50469624 |
Product used for unknown indication | 15.77 | 12.35 | 7 | 38934 | 359 | 50565824 |
Urosepsis | 15.76 | 12.35 | 36 | 38905 | 15429 | 50550754 |
Adverse event | 15.69 | 12.35 | 7 | 38934 | 43756 | 50522427 |
Migraine | 15.64 | 12.35 | 21 | 38920 | 75259 | 50490924 |
Bone marrow oedema | 15.61 | 12.35 | 9 | 38932 | 805 | 50565378 |
Reticulocyte count increased | 15.57 | 12.35 | 9 | 38932 | 809 | 50565374 |
Transaminases increased | 15.57 | 12.35 | 52 | 38889 | 27772 | 50538411 |
Cellulitis | 15.48 | 12.35 | 19 | 38922 | 70779 | 50495404 |
Hepatic enzyme increased | 15.47 | 12.35 | 54 | 38887 | 137326 | 50428857 |
Pulmonary vein occlusion | 15.43 | 12.35 | 5 | 38936 | 106 | 50566077 |
VIIIth nerve injury | 15.22 | 12.35 | 3 | 38938 | 6 | 50566177 |
Cardiac murmur functional | 15.12 | 12.35 | 4 | 38937 | 40 | 50566143 |
Hepatitis cholestatic | 15.12 | 12.35 | 21 | 38920 | 6096 | 50560087 |
Myoclonus | 15.10 | 12.35 | 34 | 38907 | 14436 | 50551747 |
Disease progression | 15.07 | 12.35 | 32 | 38909 | 95834 | 50470349 |
Prescribed underdose | 15.02 | 12.35 | 36 | 38905 | 15913 | 50550270 |
Prerenal failure | 15 | 12.35 | 11 | 38930 | 1482 | 50564701 |
C-reactive protein increased | 14.99 | 12.35 | 95 | 38846 | 66379 | 50499804 |
Metastatic malignant melanoma | 14.95 | 12.35 | 10 | 38931 | 1164 | 50565019 |
Metastatic gastric cancer | 14.93 | 12.35 | 5 | 38936 | 118 | 50566065 |
Duodenal ulcer | 14.89 | 12.35 | 22 | 38919 | 6753 | 50559430 |
Coronavirus test positive | 14.84 | 12.35 | 8 | 38933 | 628 | 50565555 |
Contusion | 14.83 | 12.35 | 41 | 38900 | 112142 | 50454041 |
Kyphosis | 14.72 | 12.35 | 13 | 38928 | 2282 | 50563901 |
Psoriatic arthropathy | 14.68 | 12.35 | 9 | 38932 | 47023 | 50519160 |
Cardio-respiratory arrest | 14.60 | 12.35 | 12 | 38929 | 53880 | 50512303 |
Circulatory collapse | 14.57 | 12.35 | 41 | 38900 | 19959 | 50546224 |
Necrolytic migratory erythema | 14.36 | 12.35 | 3 | 38938 | 9 | 50566174 |
Autoimmune colitis | 14.33 | 12.35 | 7 | 38934 | 447 | 50565736 |
Lordosis | 14.24 | 12.35 | 6 | 38935 | 271 | 50565912 |
Mucosal dryness | 14.14 | 12.35 | 13 | 38928 | 2404 | 50563779 |
Cholestatic liver injury | 14.08 | 12.35 | 12 | 38929 | 2009 | 50564174 |
Pleural effusion | 14.02 | 12.35 | 109 | 38832 | 81345 | 50484838 |
Wrong patient received product | 13.73 | 12.35 | 11 | 38930 | 1689 | 50564494 |
Petechiae | 13.73 | 12.35 | 30 | 38911 | 12482 | 50553701 |
CD8 lymphocytes decreased | 13.71 | 12.35 | 5 | 38936 | 153 | 50566030 |
Sinobronchitis | 13.67 | 12.35 | 5 | 38936 | 154 | 50566029 |
Fatigue | 13.64 | 12.35 | 428 | 38513 | 707173 | 49859010 |
Chronic fatigue syndrome | 13.62 | 12.35 | 9 | 38932 | 1026 | 50565157 |
Systemic inflammatory response syndrome | 13.49 | 12.35 | 18 | 38923 | 5031 | 50561152 |
Gastrointestinal tract adenoma | 13.30 | 12.35 | 6 | 38935 | 320 | 50565863 |
Piloerection | 13.30 | 12.35 | 6 | 38935 | 320 | 50565863 |
Ileus paralytic | 13.29 | 12.35 | 16 | 38925 | 4034 | 50562149 |
Defaecation disorder | 13.12 | 12.35 | 7 | 38934 | 538 | 50565645 |
Loss of personal independence in daily activities | 13.12 | 12.35 | 21 | 38920 | 70029 | 50496154 |
Hyperkinesia | 13.04 | 12.35 | 10 | 38931 | 1442 | 50564741 |
Cerebrovascular accident | 12.96 | 12.35 | 34 | 38907 | 94646 | 50471537 |
Adverse drug reaction | 12.96 | 12.35 | 14 | 38927 | 55208 | 50510975 |
Gastric mucosa erythema | 12.89 | 12.35 | 5 | 38936 | 182 | 50566001 |
Gastrointestinal infection | 12.80 | 12.35 | 21 | 38920 | 7053 | 50559130 |
Peripheral nerve lesion | 12.75 | 12.35 | 6 | 38935 | 353 | 50565830 |
Rhonchi | 12.71 | 12.35 | 12 | 38929 | 2295 | 50563888 |
Herpes zoster | 12.54 | 12.35 | 22 | 38919 | 70764 | 50495419 |
Febrile infection | 12.53 | 12.35 | 9 | 38932 | 1175 | 50565008 |
Unresponsive to stimuli | 12.47 | 12.35 | 4 | 38937 | 30605 | 50535578 |
Substance dependence | 12.46 | 12.35 | 5 | 38936 | 199 | 50565984 |
Pancreatic failure | 12.45 | 12.35 | 8 | 38933 | 870 | 50565313 |
Cardiomyopathy alcoholic | 12.42 | 12.35 | 3 | 38938 | 20 | 50566163 |
Hypertensive emergency | 12.38 | 12.35 | 10 | 38931 | 1553 | 50564630 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 1214.47 | 13.28 | 917 | 28265 | 101940 | 29443405 |
Product prescribing error | 290.76 | 13.28 | 195 | 28987 | 17781 | 29527564 |
Systemic infection | 171.50 | 13.28 | 68 | 29114 | 2033 | 29543312 |
Haematochezia | 140.91 | 13.28 | 178 | 29004 | 36805 | 29508540 |
Drug ineffective | 118.32 | 13.28 | 111 | 29071 | 363059 | 29182286 |
Anaemia | 118.18 | 13.28 | 450 | 28732 | 200501 | 29344844 |
Product monitoring error | 91.51 | 13.28 | 47 | 29135 | 2598 | 29542747 |
Death | 90.16 | 13.28 | 124 | 29058 | 341960 | 29203385 |
Agranulocytosis | 85.65 | 13.28 | 103 | 29079 | 20237 | 29525108 |
Abdominal pain | 81.76 | 13.28 | 306 | 28876 | 135051 | 29410294 |
Pallor | 81.31 | 13.28 | 102 | 29080 | 20922 | 29524423 |
Musculoskeletal pain | 79.50 | 13.28 | 119 | 29063 | 28834 | 29516511 |
Completed suicide | 76.00 | 13.28 | 3 | 29179 | 90243 | 29455102 |
Leukopenia | 73.66 | 13.28 | 166 | 29016 | 55037 | 29490308 |
Abdominal pain upper | 58.77 | 13.28 | 162 | 29020 | 60831 | 29484514 |
Fracture | 58.04 | 13.28 | 48 | 29134 | 6005 | 29539340 |
Electrolyte imbalance | 57.41 | 13.28 | 63 | 29119 | 11211 | 29534134 |
Malaise | 56.33 | 13.28 | 45 | 29137 | 159557 | 29385788 |
Labelled drug-drug interaction medication error | 51.87 | 13.28 | 62 | 29120 | 12097 | 29533248 |
Acute abdomen | 51.79 | 13.28 | 28 | 29154 | 1719 | 29543626 |
Product dose omission issue | 50.69 | 13.28 | 16 | 29166 | 96367 | 29448978 |
Vomiting | 49.29 | 13.28 | 368 | 28814 | 211892 | 29333453 |
Paresis | 47.52 | 13.28 | 27 | 29155 | 1827 | 29543518 |
Dyspnoea | 44.61 | 13.28 | 505 | 28677 | 326227 | 29219118 |
Negative pressure pulmonary oedema | 44.37 | 13.28 | 14 | 29168 | 209 | 29545136 |
Blood pressure measurement | 43.43 | 13.28 | 13 | 29169 | 161 | 29545184 |
Nausea | 43.10 | 13.28 | 455 | 28727 | 288800 | 29256545 |
Tachycardia | 43.03 | 13.28 | 163 | 29019 | 72247 | 29473098 |
Neuromuscular block prolonged | 41.36 | 13.28 | 16 | 29166 | 447 | 29544898 |
Disturbance in attention | 41.17 | 13.28 | 75 | 29107 | 21349 | 29523996 |
C-reactive protein increased | 41.07 | 13.28 | 116 | 29066 | 44147 | 29501198 |
Dyschezia | 40.36 | 13.28 | 21 | 29161 | 1192 | 29544153 |
Mucosal haemorrhage | 38.58 | 13.28 | 22 | 29160 | 1499 | 29543846 |
Tachypnoea | 38.47 | 13.28 | 60 | 29122 | 15055 | 29530290 |
Neuropathy peripheral | 36.97 | 13.28 | 12 | 29170 | 71015 | 29474330 |
Platelet dysfunction | 36.58 | 13.28 | 12 | 29170 | 204 | 29545141 |
Myocardial infarction | 36.55 | 13.28 | 33 | 29149 | 110263 | 29435082 |
Polyneuropathy | 36.31 | 13.28 | 52 | 29130 | 12100 | 29533245 |
Pyrexia | 34.54 | 13.28 | 434 | 28748 | 287188 | 29258157 |
Appendicolith | 34.20 | 13.28 | 28 | 29154 | 3452 | 29541893 |
Micturition disorder | 34.05 | 13.28 | 22 | 29160 | 1879 | 29543466 |
Restlessness | 33.39 | 13.28 | 70 | 29112 | 22075 | 29523270 |
Fall | 33.37 | 13.28 | 293 | 28889 | 176885 | 29368460 |
Oedema peripheral | 33.35 | 13.28 | 195 | 28987 | 103362 | 29441983 |
Weight bearing difficulty | 31.65 | 13.28 | 16 | 29166 | 855 | 29544490 |
Gamma-glutamyltransferase increased | 30.84 | 13.28 | 76 | 29106 | 26661 | 29518684 |
Impaired healing | 30.65 | 13.28 | 51 | 29131 | 13507 | 29531838 |
Toxic epidermal necrolysis | 30.48 | 13.28 | 60 | 29122 | 18093 | 29527252 |
Constipation | 29.94 | 13.28 | 204 | 28978 | 113956 | 29431389 |
Toxicity to various agents | 29.80 | 13.28 | 81 | 29101 | 173580 | 29371765 |
Cachexia | 29.79 | 13.28 | 34 | 29148 | 6315 | 29539030 |
Leptotrichia infection | 28.74 | 13.28 | 8 | 29174 | 75 | 29545270 |
Dizziness | 28.45 | 13.28 | 299 | 28883 | 189385 | 29355960 |
Blood pressure increased | 28.35 | 13.28 | 19 | 29163 | 73784 | 29471561 |
Accessory spleen | 27.94 | 13.28 | 9 | 29173 | 144 | 29545201 |
Interstitial lung disease | 27.90 | 13.28 | 11 | 29171 | 57707 | 29487638 |
Electrocardiogram abnormal | 27.46 | 13.28 | 35 | 29147 | 7287 | 29538058 |
Product administration error | 27.36 | 13.28 | 50 | 29132 | 14260 | 29531085 |
Hospitalisation | 27.27 | 13.28 | 6 | 29176 | 45982 | 29499363 |
Therapeutic drug monitoring analysis not performed | 27.03 | 13.28 | 12 | 29170 | 478 | 29544867 |
Feeling abnormal | 26.94 | 13.28 | 10 | 29172 | 54435 | 29490910 |
Treatment failure | 25.98 | 13.28 | 3 | 29179 | 36936 | 29508409 |
Malignant neoplasm progression | 25.68 | 13.28 | 142 | 29040 | 73717 | 29471628 |
Hydrocholecystis | 25.59 | 13.28 | 10 | 29172 | 287 | 29545058 |
Suspected product contamination | 25.50 | 13.28 | 7 | 29175 | 62 | 29545283 |
Infusion related reaction | 25.47 | 13.28 | 6 | 29176 | 43880 | 29501465 |
Wound | 25.45 | 13.28 | 44 | 29138 | 12019 | 29533326 |
Platelet count decreased | 25.41 | 13.28 | 40 | 29142 | 104632 | 29440713 |
Depressed level of consciousness | 25.18 | 13.28 | 87 | 29095 | 36855 | 29508490 |
Product prescribing issue | 24.66 | 13.28 | 15 | 29167 | 1152 | 29544193 |
Hypertensive crisis | 24.06 | 13.28 | 34 | 29148 | 7814 | 29537531 |
Long QT syndrome | 23.96 | 13.28 | 19 | 29163 | 2239 | 29543106 |
Iris adhesions | 23.69 | 13.28 | 9 | 29173 | 239 | 29545106 |
Contraindicated product administered | 23.30 | 13.28 | 54 | 29128 | 18212 | 29527133 |
Hepatorenal failure | 23.01 | 13.28 | 11 | 29171 | 520 | 29544825 |
Tension headache | 22.54 | 13.28 | 15 | 29167 | 1346 | 29543999 |
Angioedema | 22.48 | 13.28 | 76 | 29106 | 31839 | 29513506 |
Cardiac arrest | 22.44 | 13.28 | 31 | 29151 | 85560 | 29459785 |
Cold sweat | 22.36 | 13.28 | 35 | 29147 | 8807 | 29536538 |
Erysipelas | 22.19 | 13.28 | 24 | 29158 | 4201 | 29541144 |
Implant site inflammation | 22.15 | 13.28 | 7 | 29175 | 105 | 29545240 |
Medication error | 22.07 | 13.28 | 58 | 29124 | 21153 | 29524192 |
Drug abuse | 21.89 | 13.28 | 28 | 29154 | 79855 | 29465490 |
Drug reaction with eosinophilia and systemic symptoms | 21.82 | 13.28 | 69 | 29113 | 27923 | 29517422 |
Osteochondrosis | 21.35 | 13.28 | 12 | 29170 | 795 | 29544550 |
Thirst | 21.21 | 13.28 | 29 | 29153 | 6462 | 29538883 |
Hyperventilation | 21.13 | 13.28 | 18 | 29164 | 2344 | 29543001 |
Suspected product quality issue | 20.47 | 13.28 | 7 | 29175 | 136 | 29545209 |
Joint swelling | 20.12 | 13.28 | 12 | 29170 | 49618 | 29495727 |
Pseudarthrosis | 20.07 | 13.28 | 6 | 29176 | 74 | 29545271 |
Immobile | 19.86 | 13.28 | 17 | 29165 | 2228 | 29543117 |
Appendicitis | 19.81 | 13.28 | 33 | 29149 | 8746 | 29536599 |
Thrombosis | 19.53 | 13.28 | 9 | 29173 | 43036 | 29502309 |
Mineral supplementation | 19.50 | 13.28 | 6 | 29176 | 82 | 29545263 |
Febrile infection | 19.43 | 13.28 | 16 | 29166 | 1988 | 29543357 |
Hepatic cyst | 19.35 | 13.28 | 17 | 29165 | 2308 | 29543037 |
Tracheal atresia | 19.30 | 13.28 | 4 | 29178 | 8 | 29545337 |
Therapeutic product effect decreased | 19.26 | 13.28 | 3 | 29179 | 29448 | 29515897 |
Toxic neuropathy | 19.02 | 13.28 | 9 | 29173 | 416 | 29544929 |
Intestinal haemorrhage | 18.87 | 13.28 | 19 | 29163 | 3060 | 29542285 |
Abdominal discomfort | 18.84 | 13.28 | 12 | 29170 | 47891 | 29497454 |
Haematoma | 18.82 | 13.28 | 58 | 29124 | 23154 | 29522191 |
Chronic fatigue syndrome | 18.80 | 13.28 | 8 | 29174 | 287 | 29545058 |
Flank pain | 18.76 | 13.28 | 26 | 29156 | 5867 | 29539478 |
Genitourinary tract infection | 18.51 | 13.28 | 6 | 29176 | 98 | 29545247 |
Jaundice | 18.25 | 13.28 | 67 | 29115 | 29229 | 29516116 |
Pulmonary sepsis | 18.25 | 13.28 | 15 | 29167 | 1859 | 29543486 |
Dysdiadochokinesis | 18.25 | 13.28 | 7 | 29175 | 191 | 29545154 |
Adrenocortical insufficiency acute | 18.21 | 13.28 | 13 | 29169 | 1307 | 29544038 |
Therapy partial responder | 18.17 | 13.28 | 24 | 29158 | 5175 | 29540170 |
Platelet function test abnormal | 18.13 | 13.28 | 6 | 29176 | 105 | 29545240 |
Vertigo | 18.07 | 13.28 | 55 | 29127 | 21806 | 29523539 |
Haematemesis | 17.66 | 13.28 | 59 | 29123 | 24567 | 29520778 |
Tonsillitis | 17.43 | 13.28 | 15 | 29167 | 1980 | 29543365 |
Disease progression | 17.42 | 13.28 | 34 | 29148 | 81882 | 29463463 |
Haemorrhagic necrotic pancreatitis | 17.25 | 13.28 | 6 | 29176 | 123 | 29545222 |
Urogenital infection bacterial | 17.16 | 13.28 | 5 | 29177 | 56 | 29545289 |
Paraparesis | 16.93 | 13.28 | 14 | 29168 | 1750 | 29543595 |
Reflux nephropathy | 16.92 | 13.28 | 5 | 29177 | 59 | 29545286 |
Cardiovascular disorder | 16.80 | 13.28 | 31 | 29151 | 8904 | 29536441 |
Fear of disease | 16.69 | 13.28 | 7 | 29175 | 242 | 29545103 |
Therapy non-responder | 16.47 | 13.28 | 5 | 29177 | 30906 | 29514439 |
Blood folate increased | 16.45 | 13.28 | 7 | 29175 | 251 | 29545094 |
Thrombocytopenia | 16.33 | 13.28 | 204 | 28978 | 134619 | 29410726 |
Spinal cord injury cauda equina | 16.29 | 13.28 | 6 | 29176 | 146 | 29545199 |
Somatosensory evoked potentials abnormal | 16.06 | 13.28 | 6 | 29176 | 152 | 29545193 |
Breath sounds normal | 15.69 | 13.28 | 3 | 29179 | 3 | 29545342 |
Nail bed inflammation | 15.63 | 13.28 | 6 | 29176 | 164 | 29545181 |
Unevaluable event | 15.60 | 13.28 | 5 | 29177 | 29846 | 29515499 |
Oedematous pancreatitis | 15.59 | 13.28 | 8 | 29174 | 441 | 29544904 |
Unresponsive to stimuli | 15.47 | 13.28 | 3 | 29179 | 25123 | 29520222 |
Drug intolerance | 15.39 | 13.28 | 15 | 29167 | 48364 | 29496981 |
Coma | 15.35 | 13.28 | 10 | 29172 | 39440 | 29505905 |
Vitamin B6 deficiency | 15.27 | 13.28 | 6 | 29176 | 175 | 29545170 |
Mycobacterium fortuitum infection | 15.27 | 13.28 | 6 | 29176 | 175 | 29545170 |
Food interaction | 15.10 | 13.28 | 10 | 29172 | 890 | 29544455 |
Product packaging confusion | 14.93 | 13.28 | 4 | 29178 | 32 | 29545313 |
Hyponatraemia | 14.91 | 13.28 | 116 | 29066 | 67517 | 29477828 |
Flushing | 14.90 | 13.28 | 5 | 29177 | 28987 | 29516358 |
Spinal pain | 14.80 | 13.28 | 21 | 29161 | 4843 | 29540502 |
Autoimmune hepatitis | 14.76 | 13.28 | 18 | 29164 | 3584 | 29541761 |
Fear of falling | 14.68 | 13.28 | 7 | 29175 | 329 | 29545016 |
Quality of life decreased | 14.51 | 13.28 | 17 | 29165 | 3245 | 29542100 |
Preternatural anus | 14.49 | 13.28 | 5 | 29177 | 100 | 29545245 |
Lack of application site rotation | 14.48 | 13.28 | 3 | 29179 | 6 | 29545339 |
Wrong product administered | 14.44 | 13.28 | 20 | 29162 | 4511 | 29540834 |
Oral herpes | 14.44 | 13.28 | 20 | 29162 | 4512 | 29540833 |
Paraplegia | 14.38 | 13.28 | 15 | 29167 | 2519 | 29542826 |
Target skin lesion | 14.16 | 13.28 | 3 | 29179 | 7 | 29545338 |
Flatulence | 14.12 | 13.28 | 44 | 29138 | 17665 | 29527680 |
Aspirin-exacerbated respiratory disease | 14.11 | 13.28 | 7 | 29175 | 359 | 29544986 |
Creatinine renal clearance abnormal | 14.11 | 13.28 | 6 | 29176 | 215 | 29545130 |
Upper respiratory tract irritation | 14.05 | 13.28 | 4 | 29178 | 41 | 29545304 |
Decreased vibratory sense | 14.01 | 13.28 | 7 | 29175 | 365 | 29544980 |
Polyneuropathy in malignant disease | 13.96 | 13.28 | 5 | 29177 | 112 | 29545233 |
Urosepsis | 13.96 | 13.28 | 32 | 29150 | 10714 | 29534631 |
Chills | 13.94 | 13.28 | 119 | 29063 | 71181 | 29474164 |
Procedural pain | 13.93 | 13.28 | 19 | 29163 | 4225 | 29541120 |
Abdominal distension | 13.82 | 13.28 | 85 | 29097 | 45826 | 29499519 |
Cardiac disorder | 13.76 | 13.28 | 10 | 29172 | 37253 | 29508092 |
Administration site discomfort | 13.71 | 13.28 | 4 | 29178 | 45 | 29545300 |
Urine uric acid decreased | 13.64 | 13.28 | 5 | 29177 | 120 | 29545225 |
Tracheal pain | 13.63 | 13.28 | 4 | 29178 | 46 | 29545299 |
Anaemia of malignant disease | 13.59 | 13.28 | 7 | 29175 | 389 | 29544956 |
Type I hypersensitivity | 13.52 | 13.28 | 10 | 29172 | 1062 | 29544283 |
Urinary sediment abnormal | 13.48 | 13.28 | 5 | 29177 | 124 | 29545221 |
Ureteric dilatation | 13.37 | 13.28 | 5 | 29177 | 127 | 29545218 |
Bladder spasm | 13.36 | 13.28 | 9 | 29173 | 824 | 29544521 |
Drug delivery device placement | 13.33 | 13.28 | 5 | 29177 | 128 | 29545217 |
Bifascicular block | 13.33 | 13.28 | 6 | 29176 | 247 | 29545098 |
Heart rate decreased | 13.33 | 13.28 | 4 | 29178 | 24908 | 29520437 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 2441.91 | 12.11 | 1811 | 59700 | 202614 | 64234607 |
Product prescribing error | 754.80 | 12.11 | 451 | 61060 | 34818 | 64402403 |
Haematochezia | 424.03 | 12.11 | 412 | 61099 | 65961 | 64371260 |
Systemic infection | 340.31 | 12.11 | 135 | 61376 | 4186 | 64433035 |
Anaemia | 334.78 | 12.11 | 952 | 60559 | 377728 | 64059493 |
Agranulocytosis | 289.61 | 12.11 | 261 | 61250 | 37968 | 64399253 |
Product monitoring error | 280.93 | 12.11 | 126 | 61385 | 5328 | 64431893 |
Fracture | 230.88 | 12.11 | 170 | 61341 | 18585 | 64418636 |
Drug ineffective | 220.78 | 12.11 | 288 | 61223 | 839959 | 63597262 |
Pallor | 173.08 | 12.11 | 199 | 61312 | 38582 | 64398639 |
Completed suicide | 154.28 | 12.11 | 17 | 61494 | 224397 | 64212824 |
Leukopenia | 141.57 | 12.11 | 304 | 61207 | 100938 | 64336283 |
Abdominal pain | 139.89 | 12.11 | 629 | 60882 | 311746 | 64125475 |
Aspirin-exacerbated respiratory disease | 137.88 | 12.11 | 49 | 61462 | 1111 | 64436110 |
Labelled drug-drug interaction medication error | 133.38 | 12.11 | 133 | 61378 | 21929 | 64415292 |
Fall | 130.48 | 12.11 | 759 | 60752 | 416067 | 64021154 |
Haematemesis | 129.42 | 12.11 | 190 | 61321 | 46809 | 64390412 |
Polyneuropathy | 122.25 | 12.11 | 121 | 61390 | 19773 | 64417448 |
Abdominal pain upper | 118.70 | 12.11 | 402 | 61109 | 174628 | 64262593 |
Malaise | 116.24 | 12.11 | 124 | 61387 | 396123 | 64041098 |
Vomiting | 115.77 | 12.11 | 909 | 60602 | 550208 | 63887013 |
Joint swelling | 114.15 | 12.11 | 32 | 61479 | 215350 | 64221871 |
Product administration error | 113.60 | 12.11 | 136 | 61375 | 27507 | 64409714 |
Product dose omission issue | 112.83 | 12.11 | 24 | 61487 | 194723 | 64242498 |
Musculoskeletal pain | 112.36 | 12.11 | 243 | 61268 | 81051 | 64356170 |
Restlessness | 109.77 | 12.11 | 161 | 61350 | 39624 | 64397597 |
Dyspnoea | 109.61 | 12.11 | 1105 | 60406 | 717569 | 63719652 |
Electrolyte imbalance | 106.71 | 12.11 | 126 | 61385 | 25117 | 64412104 |
Nausea | 105.27 | 12.11 | 1177 | 60334 | 784623 | 63652598 |
Tachypnoea | 96.73 | 12.11 | 123 | 61388 | 26448 | 64410773 |
Infusion related reaction | 95.81 | 12.11 | 20 | 61491 | 164447 | 64272774 |
Abdominal discomfort | 87.88 | 12.11 | 32 | 61479 | 182290 | 64254931 |
Cardiac failure congestive | 86.94 | 12.11 | 11 | 61500 | 130569 | 64306652 |
Toxic epidermal necrolysis | 86.48 | 12.11 | 139 | 61372 | 37027 | 64400194 |
Disturbance in attention | 84.04 | 12.11 | 145 | 61366 | 40929 | 64396292 |
Tachycardia | 83.89 | 12.11 | 323 | 61188 | 149256 | 64287965 |
Pyrexia | 78.33 | 12.11 | 845 | 60666 | 557799 | 63879422 |
Treatment failure | 77.38 | 12.11 | 10 | 61501 | 116806 | 64320415 |
Abdominal pain lower | 77.21 | 12.11 | 110 | 61401 | 26359 | 64410862 |
Oedema peripheral | 74.94 | 12.11 | 397 | 61114 | 209920 | 64227301 |
Synovitis | 74.87 | 12.11 | 5 | 61506 | 99085 | 64338136 |
Therapeutic product effect decreased | 71.50 | 12.11 | 12 | 61499 | 115339 | 64321882 |
Constipation | 71.13 | 12.11 | 417 | 61094 | 228920 | 64208301 |
Sinusitis | 69.66 | 12.11 | 26 | 61485 | 145902 | 64291319 |
Lower respiratory tract infection | 68.03 | 12.11 | 6 | 61505 | 94608 | 64342613 |
Arthropathy | 67.84 | 12.11 | 16 | 61495 | 120951 | 64316270 |
Jaundice | 66.99 | 12.11 | 145 | 61366 | 48367 | 64388854 |
Erysipelas | 66.76 | 12.11 | 61 | 61450 | 9020 | 64428201 |
Gamma-glutamyltransferase increased | 64.72 | 12.11 | 143 | 61368 | 48367 | 64388854 |
Medication error | 64.09 | 12.11 | 145 | 61366 | 49821 | 64387400 |
Injection site pain | 63.94 | 12.11 | 14 | 61497 | 111394 | 64325827 |
Drug intolerance | 63.05 | 12.11 | 52 | 61459 | 187940 | 64249281 |
Osteochondrosis | 62.98 | 12.11 | 30 | 61481 | 1457 | 64435764 |
Death | 61.84 | 12.11 | 244 | 61267 | 482461 | 63954760 |
Hepatorenal failure | 60.11 | 12.11 | 27 | 61484 | 1145 | 64436076 |
Blood pressure increased | 60.04 | 12.11 | 46 | 61465 | 172506 | 64264715 |
Swelling | 59.29 | 12.11 | 40 | 61471 | 160178 | 64277043 |
Musculoskeletal stiffness | 58.72 | 12.11 | 22 | 61489 | 123184 | 64314037 |
Drug-induced liver injury | 58.61 | 12.11 | 136 | 61375 | 47507 | 64389714 |
Suspected product quality issue | 58.45 | 12.11 | 18 | 61493 | 256 | 64436965 |
Apathy | 57.59 | 12.11 | 62 | 61449 | 11170 | 64426051 |
Acute abdomen | 57.46 | 12.11 | 35 | 61476 | 2789 | 64434432 |
Cachexia | 56.51 | 12.11 | 56 | 61455 | 9161 | 64428060 |
Therapeutic drug monitoring analysis not performed | 56.11 | 12.11 | 26 | 61485 | 1186 | 64436035 |
Dizziness | 55.75 | 12.11 | 641 | 60870 | 429522 | 64007699 |
Malignant neoplasm progression | 55.48 | 12.11 | 234 | 61277 | 112637 | 64324584 |
Lethargy | 53.86 | 12.11 | 4 | 61507 | 72590 | 64364631 |
Haematoma | 53.61 | 12.11 | 129 | 61382 | 46121 | 64391100 |
Drug hypersensitivity | 50.15 | 12.11 | 94 | 61417 | 237721 | 64199500 |
Dyschezia | 49.38 | 12.11 | 30 | 61481 | 2380 | 64434841 |
Nasal disorder | 49.29 | 12.11 | 32 | 61479 | 2852 | 64434369 |
Myocardial infarction | 48.40 | 12.11 | 52 | 61459 | 165769 | 64271452 |
Paresis | 47.98 | 12.11 | 34 | 61477 | 3498 | 64433723 |
Suspected product contamination | 46.85 | 12.11 | 12 | 61499 | 82 | 64437139 |
Feeling abnormal | 45.98 | 12.11 | 36 | 61475 | 133566 | 64303655 |
Mucosal haemorrhage | 45.72 | 12.11 | 28 | 61483 | 2253 | 64434968 |
Dehydration | 45.51 | 12.11 | 358 | 61153 | 216405 | 64220816 |
Negative pressure pulmonary oedema | 44.59 | 12.11 | 14 | 61497 | 213 | 64437008 |
Thirst | 44.58 | 12.11 | 61 | 61450 | 14076 | 64423145 |
Nasopharyngitis | 44.50 | 12.11 | 74 | 61437 | 195999 | 64241222 |
Toxicity to various agents | 44.45 | 12.11 | 187 | 61324 | 363326 | 64073895 |
Interstitial lung disease | 44.03 | 12.11 | 19 | 61492 | 97713 | 64339508 |
Subileus | 43.74 | 12.11 | 37 | 61474 | 4940 | 64432281 |
Drug reaction with eosinophilia and systemic symptoms | 43.47 | 12.11 | 132 | 61379 | 54085 | 64383136 |
Immobile | 43.43 | 12.11 | 40 | 61471 | 5975 | 64431246 |
Pemphigus | 43.22 | 12.11 | 4 | 61507 | 60697 | 64376524 |
Stevens-Johnson syndrome | 40.20 | 12.11 | 96 | 61415 | 34153 | 64403068 |
Rheumatoid arthritis | 40.14 | 12.11 | 59 | 61452 | 164235 | 64272986 |
Renal impairment | 39.56 | 12.11 | 242 | 61269 | 134775 | 64302446 |
Tumour pain | 39.44 | 12.11 | 24 | 61487 | 1909 | 64435312 |
Type I hypersensitivity | 38.66 | 12.11 | 30 | 61481 | 3544 | 64433677 |
Systemic lupus erythematosus | 38.44 | 12.11 | 13 | 61498 | 77599 | 64359622 |
Electrocardiogram abnormal | 37.81 | 12.11 | 55 | 61456 | 13426 | 64423795 |
Arthralgia | 37.68 | 12.11 | 257 | 61254 | 442003 | 63995218 |
Psoriasis | 37.31 | 12.11 | 11 | 61500 | 71692 | 64365529 |
Dysuria | 37.16 | 12.11 | 106 | 61405 | 41951 | 64395270 |
Wound | 37.13 | 12.11 | 158 | 61353 | 76319 | 64360902 |
Drug interaction | 36.40 | 12.11 | 515 | 60996 | 361568 | 64075653 |
Neuropathy peripheral | 36.39 | 12.11 | 35 | 61476 | 117490 | 64319731 |
Urogenital haemorrhage | 35.94 | 12.11 | 16 | 61495 | 664 | 64436557 |
Thrombocytopenia | 35.71 | 12.11 | 348 | 61163 | 223453 | 64213768 |
Syncope | 35.66 | 12.11 | 265 | 61246 | 157370 | 64279851 |
Pericarditis | 35.57 | 12.11 | 8 | 61503 | 62508 | 64374713 |
Nasal congestion | 35.25 | 12.11 | 7 | 61504 | 59651 | 64377570 |
Therapy non-responder | 34.49 | 12.11 | 10 | 61501 | 65889 | 64371332 |
Flank pain | 34.22 | 12.11 | 58 | 61453 | 16131 | 64421090 |
Maternal exposure during pregnancy | 34.06 | 12.11 | 25 | 61486 | 95859 | 64341362 |
Respiratory arrest | 33.98 | 12.11 | 5 | 61506 | 52980 | 64384241 |
Cellulitis | 33.81 | 12.11 | 24 | 61487 | 93633 | 64343588 |
Blood pressure measurement | 33.38 | 12.11 | 13 | 61498 | 383 | 64436838 |
Spinal pain | 33.25 | 12.11 | 50 | 61461 | 12571 | 64424650 |
Platelet count decreased | 33.00 | 12.11 | 69 | 61442 | 167642 | 64269579 |
Appendicolith | 33.00 | 12.11 | 27 | 61484 | 3442 | 64433779 |
Acute hepatic failure | 32.61 | 12.11 | 75 | 61436 | 26037 | 64411184 |
Hepatitis acute | 32.41 | 12.11 | 51 | 61460 | 13338 | 64423883 |
Faecaloma | 32.23 | 12.11 | 43 | 61468 | 9685 | 64427536 |
Urogenital infection bacterial | 32.11 | 12.11 | 9 | 61502 | 90 | 64437131 |
Chills | 31.75 | 12.11 | 232 | 61279 | 137032 | 64300189 |
Hospitalisation | 31.75 | 12.11 | 16 | 61495 | 75191 | 64362030 |
Hypokalaemia | 31.70 | 12.11 | 212 | 61299 | 121691 | 64315530 |
Alopecia | 31.08 | 12.11 | 70 | 61441 | 165620 | 64271601 |
C-reactive protein increased | 30.95 | 12.11 | 175 | 61336 | 94734 | 64342487 |
Angina pectoris | 30.89 | 12.11 | 104 | 61407 | 44977 | 64392244 |
Platelet dysfunction | 30.83 | 12.11 | 12 | 61499 | 353 | 64436868 |
Disease progression | 30.74 | 12.11 | 55 | 61456 | 141625 | 64295596 |
Arrhythmia | 30.19 | 12.11 | 115 | 61396 | 52829 | 64384392 |
Chronic fatigue syndrome | 30.08 | 12.11 | 17 | 61494 | 1178 | 64436043 |
Listless | 30.03 | 12.11 | 25 | 61486 | 3265 | 64433956 |
Abdominal distension | 29.99 | 12.11 | 175 | 61336 | 95819 | 64341402 |
Heart rate increased | 29.84 | 12.11 | 30 | 61481 | 98645 | 64338576 |
Injection site swelling | 28.72 | 12.11 | 3 | 61508 | 41350 | 64395871 |
Injection site erythema | 28.51 | 12.11 | 16 | 61495 | 70784 | 64366437 |
Febrile infection | 28.48 | 12.11 | 23 | 61488 | 2878 | 64434343 |
Off label use | 28.34 | 12.11 | 429 | 61082 | 632377 | 63804844 |
Bicytopenia | 27.94 | 12.11 | 25 | 61486 | 3597 | 64433624 |
Reduced facial expression | 27.92 | 12.11 | 20 | 61491 | 2093 | 64435128 |
Depressed level of consciousness | 27.78 | 12.11 | 152 | 61359 | 81284 | 64355937 |
Ascites | 27.74 | 12.11 | 125 | 61386 | 61876 | 64375345 |
Heart rate decreased | 27.66 | 12.11 | 9 | 61502 | 55058 | 64382163 |
Neuromuscular block prolonged | 27.62 | 12.11 | 15 | 61496 | 962 | 64436259 |
Unresponsive to stimuli | 27.59 | 12.11 | 7 | 61504 | 50386 | 64386835 |
Pancytopenia | 27.51 | 12.11 | 232 | 61279 | 143077 | 64294144 |
Cardio-respiratory arrest | 27.44 | 12.11 | 32 | 61479 | 98361 | 64338860 |
Therapeutic product effect incomplete | 27.44 | 12.11 | 35 | 61476 | 103447 | 64333774 |
Product use issue | 26.93 | 12.11 | 66 | 61445 | 151649 | 64285572 |
Bradycardia | 26.87 | 12.11 | 199 | 61312 | 118020 | 64319201 |
Micturition disorder | 26.84 | 12.11 | 23 | 61488 | 3125 | 64434096 |
Facial nerve disorder | 26.79 | 12.11 | 13 | 61498 | 658 | 64436563 |
Hypoaesthesia | 26.72 | 12.11 | 58 | 61453 | 139050 | 64298171 |
Gastritis erosive | 26.70 | 12.11 | 39 | 61472 | 9556 | 64427665 |
Accessory spleen | 26.57 | 12.11 | 9 | 61502 | 176 | 64437045 |
Orthostatic hypotension | 26.55 | 12.11 | 6 | 61505 | 46732 | 64390489 |
Contusion | 25.85 | 12.11 | 43 | 61468 | 113922 | 64323299 |
Angioedema | 25.71 | 12.11 | 122 | 61389 | 61699 | 64375522 |
Fluid intake reduced | 25.43 | 12.11 | 28 | 61483 | 5172 | 64432049 |
Gastrointestinal disorder | 25.21 | 12.11 | 29 | 61482 | 89680 | 64347541 |
Vertigo | 24.94 | 12.11 | 117 | 61394 | 58894 | 64378327 |
Hypersensitivity | 24.63 | 12.11 | 100 | 61411 | 196352 | 64240869 |
Haemorrhagic necrotic pancreatitis | 24.62 | 12.11 | 7 | 61504 | 74 | 64437147 |
Disorientation | 24.56 | 12.11 | 112 | 61399 | 55716 | 64381505 |
Hydrocholecystis | 24.28 | 12.11 | 10 | 61501 | 342 | 64436879 |
Nail toxicity | 24.17 | 12.11 | 10 | 61501 | 346 | 64436875 |
Long QT syndrome | 23.98 | 12.11 | 27 | 61484 | 5112 | 64432109 |
Helicobacter infection | 23.74 | 12.11 | 4 | 61507 | 38358 | 64398863 |
Hepatitis cholestatic | 23.67 | 12.11 | 42 | 61469 | 12113 | 64425108 |
Decreased appetite | 23.57 | 12.11 | 388 | 61123 | 280901 | 64156320 |
Blood pressure fluctuation | 23.49 | 12.11 | 10 | 61501 | 51861 | 64385360 |
Flatulence | 23.31 | 12.11 | 81 | 61430 | 35585 | 64401636 |
Rash | 23.28 | 12.11 | 303 | 61208 | 458246 | 63978975 |
Drug resistance | 23.25 | 12.11 | 3 | 61508 | 35099 | 64402122 |
Thirst decreased | 23.12 | 12.11 | 9 | 61502 | 265 | 64436956 |
Loss of personal independence in daily activities | 23.11 | 12.11 | 21 | 61490 | 72433 | 64364788 |
Upper gastrointestinal haemorrhage | 23.03 | 12.11 | 80 | 61431 | 35140 | 64402081 |
Gallbladder polyp | 23.03 | 12.11 | 13 | 61498 | 899 | 64436322 |
Post-traumatic pain | 22.95 | 12.11 | 10 | 61501 | 394 | 64436827 |
Cardiac arrest | 22.91 | 12.11 | 73 | 61438 | 153991 | 64283230 |
Delirium | 22.83 | 12.11 | 128 | 61383 | 69066 | 64368155 |
Psychotic disorder | 22.79 | 12.11 | 3 | 61508 | 34575 | 64402646 |
Migraine | 22.70 | 12.11 | 16 | 61495 | 62661 | 64374560 |
Flushing | 22.56 | 12.11 | 25 | 61486 | 78623 | 64358598 |
Unevaluable event | 22.45 | 12.11 | 10 | 61501 | 50479 | 64386742 |
Drug abuse | 22.40 | 12.11 | 59 | 61452 | 132315 | 64304906 |
Therapeutic response decreased | 22.18 | 12.11 | 11 | 61500 | 52177 | 64385044 |
Haematuria | 22.07 | 12.11 | 115 | 61396 | 60356 | 64376865 |
Adverse drug reaction | 21.85 | 12.11 | 8 | 61503 | 45456 | 64391765 |
Dysdiadochokinesis | 21.84 | 12.11 | 9 | 61502 | 308 | 64436913 |
Discomfort | 21.81 | 12.11 | 27 | 61484 | 80851 | 64356370 |
Weight increased | 21.79 | 12.11 | 117 | 61394 | 213231 | 64223990 |
Tension headache | 21.57 | 12.11 | 21 | 61490 | 3362 | 64433859 |
Product used for unknown indication | 21.42 | 12.11 | 12 | 61499 | 818 | 64436403 |
Muscle tone disorder | 21.25 | 12.11 | 7 | 61504 | 125 | 64437096 |
Blood folate increased | 21.20 | 12.11 | 10 | 61501 | 475 | 64436746 |
Injection site reaction | 21.13 | 12.11 | 9 | 61502 | 46655 | 64390566 |
Coombs negative haemolytic anaemia | 20.84 | 12.11 | 9 | 61502 | 347 | 64436874 |
Urosepsis | 20.81 | 12.11 | 57 | 61454 | 22037 | 64415184 |
Hyperventilation | 20.79 | 12.11 | 29 | 61482 | 6811 | 64430410 |
Cerebrovascular accident | 20.59 | 12.11 | 65 | 61446 | 137518 | 64299703 |
Cardiac disorder | 20.55 | 12.11 | 14 | 61497 | 55802 | 64381419 |
Acute generalised exanthematous pustulosis | 20.53 | 12.11 | 43 | 61468 | 14015 | 64423206 |
Hepatitis toxic | 20.33 | 12.11 | 23 | 61488 | 4377 | 64432844 |
Blood pressure decreased | 20.04 | 12.11 | 32 | 61479 | 86167 | 64351054 |
Pelvic fracture | 19.93 | 12.11 | 36 | 61475 | 10527 | 64426694 |
Oropharyngeal discomfort | 19.89 | 12.11 | 25 | 61486 | 5310 | 64431911 |
Vascular encephalopathy | 19.63 | 12.11 | 10 | 61501 | 562 | 64436659 |
Peripheral swelling | 19.57 | 12.11 | 118 | 61393 | 209035 | 64228186 |
Pseudarthrosis | 19.47 | 12.11 | 8 | 61503 | 272 | 64436949 |
Pulmonary sepsis | 19.44 | 12.11 | 19 | 61492 | 3056 | 64434165 |
Depression | 19.00 | 12.11 | 100 | 61411 | 183191 | 64254030 |
Irritable bowel syndrome | 18.96 | 12.11 | 6 | 61505 | 37363 | 64399858 |
Hepatic function abnormal | 18.94 | 12.11 | 20 | 61491 | 64293 | 64372928 |
Folliculitis | 18.92 | 12.11 | 3 | 61508 | 30074 | 64407147 |
Pneumobilia | 18.69 | 12.11 | 7 | 61504 | 185 | 64437036 |
Duodenal ulcer | 18.62 | 12.11 | 42 | 61469 | 14393 | 64422828 |
Gastrointestinal sounds abnormal | 18.55 | 12.11 | 23 | 61488 | 4820 | 64432401 |
Localised infection | 18.43 | 12.11 | 67 | 61444 | 30094 | 64407127 |
Fluid retention | 18.16 | 12.11 | 18 | 61493 | 59588 | 64377633 |
Inappropriate schedule of product administration | 18.12 | 12.11 | 38 | 61473 | 92248 | 64344973 |
Disease recurrence | 17.99 | 12.11 | 4 | 61507 | 31506 | 64405715 |
Anaemia of malignant disease | 17.98 | 12.11 | 10 | 61501 | 672 | 64436549 |
Peripheral circulatory failure | 17.86 | 12.11 | 10 | 61501 | 681 | 64436540 |
Multiple organ dysfunction syndrome | 17.80 | 12.11 | 161 | 61350 | 101252 | 64335969 |
Hyponatraemia | 17.78 | 12.11 | 218 | 61293 | 148121 | 64289100 |
Hyperglycaemia | 17.66 | 12.11 | 109 | 61402 | 60859 | 64376362 |
Fibromyalgia | 17.66 | 12.11 | 6 | 61505 | 35725 | 64401496 |
Weight bearing difficulty | 17.65 | 12.11 | 17 | 61494 | 2686 | 64434535 |
Implant site inflammation | 17.61 | 12.11 | 7 | 61504 | 218 | 64437003 |
Medication overuse headache | 17.60 | 12.11 | 10 | 61501 | 700 | 64436521 |
White blood cell count decreased | 17.56 | 12.11 | 84 | 61427 | 157753 | 64279468 |
Hypoxia | 17.55 | 12.11 | 36 | 61475 | 88113 | 64349108 |
Ileus | 17.55 | 12.11 | 55 | 61456 | 22911 | 64414310 |
Product packaging confusion | 17.43 | 12.11 | 7 | 61504 | 224 | 64436997 |
Paraparesis | 17.37 | 12.11 | 19 | 61492 | 3483 | 64433738 |
Wrong technique in product usage process | 17.20 | 12.11 | 22 | 61489 | 64952 | 64372269 |
Head injury | 17.15 | 12.11 | 5 | 61506 | 32837 | 64404384 |
Hepatic cyst | 17.11 | 12.11 | 23 | 61488 | 5217 | 64432004 |
Psoriatic arthropathy | 17.11 | 12.11 | 10 | 61501 | 43271 | 64393950 |
Lividity | 17.04 | 12.11 | 8 | 61503 | 376 | 64436845 |
Exposure during pregnancy | 16.98 | 12.11 | 30 | 61481 | 77645 | 64359576 |
Gastritis | 16.92 | 12.11 | 83 | 61428 | 42535 | 64394686 |
Rash pruritic | 16.73 | 12.11 | 18 | 61493 | 57386 | 64379835 |
Antineutrophil cytoplasmic antibody positive | 16.73 | 12.11 | 11 | 61500 | 1001 | 64436220 |
Tonsillitis | 16.69 | 12.11 | 24 | 61487 | 5796 | 64431425 |
Product prescribing issue | 16.60 | 12.11 | 15 | 61496 | 2186 | 64435035 |
Full blood count abnormal | 16.55 | 12.11 | 4 | 61507 | 29753 | 64407468 |
Spinal cord injury cauda equina | 16.48 | 12.11 | 6 | 61505 | 146 | 64437075 |
Vasculitis | 16.36 | 12.11 | 46 | 61465 | 18049 | 64419172 |
Type 2 diabetes mellitus | 16.32 | 12.11 | 6 | 61505 | 34014 | 64403207 |
Knee arthroplasty | 16.30 | 12.11 | 3 | 61508 | 26996 | 64410225 |
Hypertensive crisis | 16.12 | 12.11 | 46 | 61465 | 18202 | 64419019 |
International normalised ratio increased | 16.05 | 12.11 | 32 | 61479 | 79135 | 64358086 |
Appendicitis | 15.88 | 12.11 | 38 | 61473 | 13531 | 64423690 |
Vitamin B6 deficiency | 15.87 | 12.11 | 7 | 61504 | 284 | 64436937 |
Breath sounds normal | 15.79 | 12.11 | 3 | 61508 | 3 | 64437218 |
Respiratory alkalosis | 15.72 | 12.11 | 19 | 61492 | 3878 | 64433343 |
Seizure | 15.69 | 12.11 | 94 | 61417 | 166798 | 64270423 |
Pulmonary hypertension | 15.64 | 12.11 | 11 | 61500 | 43128 | 64394093 |
Cardiac failure | 15.63 | 12.11 | 194 | 61317 | 132179 | 64305042 |
Peritoneal perforation | 15.63 | 12.11 | 6 | 61505 | 170 | 64437051 |
Prescribed underdose | 15.52 | 12.11 | 45 | 61466 | 17970 | 64419251 |
Hepatic failure | 15.40 | 12.11 | 98 | 61413 | 55296 | 64381925 |
Amnesia | 15.38 | 12.11 | 14 | 61497 | 48255 | 64388966 |
Haemorrhagic erosive gastritis | 15.38 | 12.11 | 8 | 61503 | 470 | 64436751 |
Necrotising fasciitis | 15.33 | 12.11 | 22 | 61489 | 5304 | 64431917 |
Somatosensory evoked potentials abnormal | 15.27 | 12.11 | 6 | 61505 | 181 | 64437040 |
Product impurity | 15.25 | 12.11 | 5 | 61506 | 88 | 64437133 |
Agitation | 15.24 | 12.11 | 39 | 61472 | 88328 | 64348893 |
Oliguria | 15.14 | 12.11 | 39 | 61472 | 14537 | 64422684 |
Lordosis | 15.05 | 12.11 | 7 | 61504 | 322 | 64436899 |
Hypervolaemia | 14.91 | 12.11 | 9 | 61502 | 38276 | 64398945 |
Conjunctivitis | 14.88 | 12.11 | 48 | 61463 | 20306 | 64416915 |
Head discomfort | 14.79 | 12.11 | 34 | 61477 | 11800 | 64425421 |
Preternatural anus | 14.65 | 12.11 | 5 | 61506 | 100 | 64437121 |
Hepatocellular injury | 14.55 | 12.11 | 13 | 61498 | 45222 | 64391999 |
Mycobacterium fortuitum infection | 14.55 | 12.11 | 6 | 61505 | 206 | 64437015 |
Cross sensitivity reaction | 14.55 | 12.11 | 17 | 61494 | 3350 | 64433871 |
Prescription drug used without a prescription | 14.48 | 12.11 | 15 | 61496 | 2585 | 64434636 |
Subacute hepatic failure | 14.46 | 12.11 | 6 | 61505 | 209 | 64437012 |
Visual acuity reduced | 14.42 | 12.11 | 4 | 61507 | 27137 | 64410084 |
Cardiac murmur functional | 14.36 | 12.11 | 4 | 61507 | 39 | 64437182 |
Toxic neuropathy | 14.02 | 12.11 | 9 | 61502 | 787 | 64436434 |
Hyperaemia | 13.97 | 12.11 | 15 | 61496 | 2694 | 64434527 |
Solar dermatitis | 13.95 | 12.11 | 6 | 61505 | 229 | 64436992 |
Urine uric acid decreased | 13.80 | 12.11 | 5 | 61506 | 120 | 64437101 |
Bulimia nervosa | 13.78 | 12.11 | 6 | 61505 | 236 | 64436985 |
Ill-defined disorder | 13.77 | 12.11 | 13 | 61498 | 44039 | 64393182 |
Tracheal pain | 13.77 | 12.11 | 4 | 61507 | 46 | 64437175 |
VIIIth nerve injury | 13.72 | 12.11 | 3 | 61508 | 9 | 64437212 |
Necrolytic migratory erythema | 13.72 | 12.11 | 3 | 61508 | 9 | 64437212 |
Anaemia folate deficiency | 13.59 | 12.11 | 6 | 61505 | 244 | 64436977 |
Reactive gastropathy | 13.43 | 12.11 | 7 | 61504 | 413 | 64436808 |
Anxiety | 13.40 | 12.11 | 126 | 61385 | 202523 | 64234698 |
Lumbar vertebral fracture | 13.37 | 12.11 | 21 | 61490 | 5481 | 64431740 |
Pulmonary vein occlusion | 13.35 | 12.11 | 5 | 61506 | 132 | 64437089 |
Intestinal haemorrhage | 13.34 | 12.11 | 21 | 61490 | 5493 | 64431728 |
Headache | 13.29 | 12.11 | 394 | 61117 | 529073 | 63908148 |
Sensory level abnormal | 13.28 | 12.11 | 5 | 61506 | 134 | 64437087 |
Skin irritation | 13.28 | 12.11 | 28 | 61483 | 9166 | 64428055 |
Genitourinary tract infection | 13.28 | 12.11 | 6 | 61505 | 258 | 64436963 |
Spontaneous haemorrhage | 13.18 | 12.11 | 7 | 61504 | 429 | 64436792 |
Concomitant disease aggravated | 13.16 | 12.11 | 32 | 61479 | 11510 | 64425711 |
Adverse event | 13.13 | 12.11 | 11 | 61500 | 39478 | 64397743 |
Oedematous pancreatitis | 13.12 | 12.11 | 9 | 61502 | 879 | 64436342 |
Laryngeal oedema | 13.11 | 12.11 | 24 | 61487 | 7089 | 64430132 |
Food interaction | 13.09 | 12.11 | 11 | 61500 | 1455 | 64435766 |
Transaminases increased | 13.09 | 12.11 | 80 | 61431 | 44514 | 64392707 |
Urinary sediment abnormal | 13.08 | 12.11 | 5 | 61506 | 140 | 64437081 |
Confusional state | 13.06 | 12.11 | 173 | 61338 | 260971 | 64176250 |
Leptotrichia infection | 13.05 | 12.11 | 4 | 61507 | 56 | 64437165 |
Stenosis | 12.97 | 12.11 | 12 | 61499 | 1803 | 64435418 |
Fear of disease | 12.96 | 12.11 | 9 | 61502 | 896 | 64436325 |
Hyperkinesia | 12.96 | 12.11 | 14 | 61497 | 2532 | 64434689 |
Wrong product administered | 12.93 | 12.11 | 25 | 61486 | 7695 | 64429526 |
Colitis | 12.89 | 12.11 | 98 | 61413 | 58576 | 64378645 |
Oral candidiasis | 12.88 | 12.11 | 50 | 61461 | 23162 | 64414059 |
Adrenocortical insufficiency acute | 12.87 | 12.11 | 14 | 61497 | 2551 | 64434670 |
Organic brain syndrome | 12.86 | 12.11 | 7 | 61504 | 451 | 64436770 |
Mucosal dryness | 12.71 | 12.11 | 15 | 61496 | 2986 | 64434235 |
Lack of application site rotation | 12.68 | 12.11 | 3 | 61508 | 14 | 64437207 |
Gastric disorder | 12.64 | 12.11 | 6 | 61505 | 29191 | 64408030 |
Polyneuropathy in malignant disease | 12.60 | 12.11 | 5 | 61506 | 155 | 64437066 |
Alpha 2 globulin increased | 12.60 | 12.11 | 5 | 61506 | 155 | 64437066 |
Rhabdomyolysis | 12.58 | 12.11 | 45 | 61466 | 91681 | 64345540 |
Pure white cell aplasia | 12.55 | 12.11 | 4 | 61507 | 64 | 64437157 |
Brain contusion | 12.54 | 12.11 | 10 | 61501 | 1229 | 64435992 |
Tumour haemorrhage | 12.44 | 12.11 | 16 | 61495 | 3477 | 64433744 |
Non-small cell lung cancer | 12.35 | 12.11 | 19 | 61492 | 4871 | 64432350 |
Arthritis | 12.25 | 12.11 | 40 | 61471 | 83774 | 64353447 |
Peripheral arterial occlusive disease | 12.16 | 12.11 | 23 | 61488 | 6964 | 64430257 |
Ureteric dilatation | 12.14 | 12.11 | 5 | 61506 | 171 | 64437050 |
Paraplegia | 12.13 | 12.11 | 18 | 61493 | 4472 | 64432749 |
None
Source | Code | Description |
---|---|---|
ATC | N02BB02 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones |
ATC | N02BB52 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones |
ATC | N02BB72 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D058633 | Antipyretics |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
CHEBI has role | CHEBI:35493 | anti-pyretic |
CHEBI has role | CHEBI:35842 | anti-rheumatic drugs |
CHEBI has role | CHEBI:49110 | peripheral nervous system drugs |
CHEBI has role | CHEBI:50266 | Prodrugs |
CHEBI has role | CHEBI:73263 | cyclooxygenase-3 inhibitors |
None
None
Product | Applicant | Ingredients |
---|---|---|
Zimeta | Kindred Biosciences Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 0.21 | acidic |
pKa2 | 5.06 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily A member 1 | Ion channel | BLOCKER | IC50 | 4.04 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
ID | Source |
---|---|
D08190 | KEGG_DRUG |
N0000167060 | NUI |
5907-38-0 | SECONDARY_CAS_RN |
CHEBI:59033 | CHEBI |
CHEMBL3989803 | ChEMBL_ID |
C024864 | MESH_SUPPLEMENTAL_RECORD_UI |
10608 | IUPHAR_LIGAND_ID |
6150-97-6 | SECONDARY_CAS_RN |
51996-59-9 | SECONDARY_CAS_RN |
DB04817 | DRUGBANK_ID |
934T64RMNJ | UNII |
3111 | PUBCHEM_CID |
1537943 | RXNORM |
NOCODE | MMSL |
001609 | NDDF |
006029 | NDDF |
22165008 | SNOMEDCT_US |
735071007 | SNOMEDCT_US |
780831000 | SNOMEDCT_US |
781025005 | SNOMEDCT_US |
D004177 | MESH_DESCRIPTOR_UI |
C0012586 | UMLSCUI |
CHEMBL461522 | ChEMBL_ID |
477 | INN_ID |
50567-35-6 | SECONDARY_CAS_RN |
None