aminophenazone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory analgesics, phenylbutazone derivatives 171 58-15-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aminophenazone
  • aminopyrine
  • amidazophen
  • amidazophene
  • amidofebrin
  • amidofen
  • amidophen
  • amidophenazone
  • amidopyrazoline
  • amidopyrin
  • amidopyrine
  • aminophenazon
  • aminopyrin
  • anafebrina
  • dimethylaminoazophene
  • dimethylaminophenyldimethylpyrazone
  • pyramidon
  • pyramidone
A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.
  • Molecular weight: 231.30
  • Formula: C13H17N3O
  • CLOGP: 1.04
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 26.79
  • ALOGS: -1.01
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.50 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 55.55 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 247.05 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1964 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BB03 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB53 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB73 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35493 antipyretic

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme WOMBAT-PK
Prostaglandin G/H synthase 2 Enzyme WOMBAT-PK

External reference:

IDSource
D000632 MESH_DESCRIPTOR_UI
N0000167058 NUI
C0002586 UMLSCUI
D00556 KEGG_DRUG
01704YP3MO UNII
375 INN_ID
65458000 SNOMEDCT_US
695 RXNORM
001608 NDDF
6009 PUBCHEM_CID
CHEBI:160246 CHEBI
CHEMBL288470 ChEMBL_ID
DB01424 DRUGBANK_ID

Pharmaceutical products:

None