mecobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4600	13422-55-4

Description:

Molecule	Description
Synonyms: mecobalamin methycobal methyl cobalamine Methyl vitamin B12 methylcobalamin methylcobaz	Molecular weight: 1344.40 Formula: C63H91CoN13O14P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 488.71 ALOGS: ROTB: None

Molecule

Description

Synonyms:

mecobalamin
methycobal
methyl cobalamine
Methyl vitamin B12
methylcobalamin
methylcobaz

Molecular weight: 1344.40
Formula: C63H91CoN13O14P
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 488.71
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
1.50	mg	O
0.20	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	130.76	18.63	67	6289	37075	63445591
Platelet count decreased	120.99	18.63	97	6259	116025	63366641
Neutrophil count decreased	97.29	18.63	64	6292	56342	63426324
Interstitial lung disease	62.85	18.63	51	6305	61857	63420809
Osteonecrosis of jaw	51.34	18.63	36	6320	35087	63447579
Renal impairment	50.89	18.63	53	6303	88302	63394364
White blood cell count decreased	47.73	18.63	64	6292	139040	63343626
Anaemia	47.41	18.63	96	6260	293334	63189332
Drug eruption	45.68	18.63	31	6325	28663	63454003
Cerebral infarction	40.88	18.63	27	6329	23866	63458800
Pain	35.45	18.63	15	6341	740613	62742053
Erythema multiforme	34.75	18.63	18	6338	10151	63472515
Upper respiratory tract inflammation	34.60	18.63	12	6344	2511	63480155
Pyrexia	34.22	18.63	114	6242	470364	63012302
Drug ineffective	32.78	18.63	34	6322	1044731	62437935
Cardiac failure	30.52	18.63	41	6315	89101	63393565
Malignant neoplasm progression	30.01	18.63	39	6317	82082	63400584
Pneumonia	29.99	18.63	107	6249	456660	63026006
Decreased appetite	29.09	18.63	72	6284	250980	63231686
Lymphocyte count decreased	28.74	18.63	24	6332	30233	63452433
Altered state of consciousness	28.17	18.63	22	6334	25208	63457458
Hypoglycaemia	27.56	18.63	32	6324	60033	63422633
Spinal compression fracture	26.53	18.63	17	6339	14266	63468400
Femoral neck fracture	26.04	18.63	14	6342	8509	63474157
Febrile neutropenia	25.63	18.63	44	6312	118405	63364261
Haemorrhage subcutaneous	25.42	18.63	10	6346	2973	63479693
Herpes zoster	25.33	18.63	36	6320	82426	63400240
Pneumonia bacterial	24.66	18.63	14	6342	9451	63473215
Fatigue	24.46	18.63	32	6324	887996	62594670
Aspartate aminotransferase increased	24.25	18.63	37	6319	90240	63392426
Blood pressure decreased	23.94	18.63	31	6325	64991	63417675
Aortic aneurysm rupture	22.25	18.63	6	6350	540	63482126
Blood disorder	20.34	18.63	11	6345	6760	63475906
Disseminated intravascular coagulation	19.95	18.63	16	6340	19035	63463631
Osteomyelitis	19.42	18.63	18	6338	26002	63456664
Liver disorder	18.83	18.63	25	6331	53662	63429004
Mania	18.82	18.63	13	6343	12354	63470312

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Interstitial lung disease	115.76	17.51	95	6204	65187	34885445
Platelet count decreased	70.85	17.51	97	6202	119620	34831012
Hepatic function abnormal	63.15	17.51	57	6242	44306	34906326
Cerebral infarction	42.48	17.51	37	6262	27418	34923214
Decreased appetite	40.31	17.51	91	6208	166301	34784331
Drug-induced liver injury	37.03	17.51	35	6264	28797	34921835
Upper respiratory tract inflammation	35.72	17.51	13	6286	1731	34948901
Diabetes mellitus	35.52	17.51	43	6256	46830	34903802
Liver disorder	34.85	17.51	36	6263	32961	34917671
Fatigue	34.43	17.51	12	6287	370641	34579991
Neutrophil count decreased	34.12	17.51	44	6255	51060	34899572
Altered state of consciousness	33.70	17.51	30	6269	22863	34927769
Renal impairment	32.74	17.51	60	6239	94453	34856179
Hypopituitarism	32.32	17.51	13	6286	2269	34948363
Male sexual dysfunction	32.25	17.51	8	6291	284	34950348
White blood cell count decreased	31.07	17.51	59	6240	95386	34855246
Disseminated intravascular coagulation	30.95	17.51	28	6271	21788	34928844
Pneumonia	30.18	17.51	137	6162	362490	34588142
Drug ineffective	29.00	17.51	24	6275	456727	34493905
Spinal compression fracture	28.24	17.51	17	6282	7099	34943533
Lymphocyte count decreased	28.17	17.51	27	6272	22595	34928037
Pneumonia bacterial	24.66	17.51	19	6280	11853	34938779
Enterocolitis	23.92	17.51	16	6283	8010	34942622
Toxicity to various agents	23.39	17.51	4	6295	200358	34750274
Drug eruption	23.36	17.51	23	6276	19875	34930757
Malignant neoplasm progression	23.35	17.51	50	6249	87996	34862636
Colon cancer	22.88	17.51	16	6283	8605	34942027
Pneumonia aspiration	20.38	17.51	31	6268	41872	34908760
Pemphigoid	18.28	17.51	14	6285	8652	34941980
Adrenal insufficiency	17.93	17.51	17	6282	14030	34936602

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Platelet count decreased	194.90	15.07	197	12848	194467	79536876
Hepatic function abnormal	176.11	15.07	123	12922	72984	79658359
Interstitial lung disease	169.09	15.07	143	12902	112457	79618886
Neutrophil count decreased	126.17	15.07	112	12933	93847	79637496
White blood cell count decreased	81.24	15.07	125	12920	188163	79543180
Cerebral infarction	81.05	15.07	64	12981	45612	79685731
Renal impairment	78.48	15.07	112	12933	157671	79573672
Upper respiratory tract inflammation	66.54	15.07	25	13020	4010	79727333
Drug ineffective	65.57	15.07	49	12996	1080864	78650479
Decreased appetite	65.42	15.07	161	12884	342257	79389086
Drug eruption	62.17	15.07	54	12991	43881	79687462
Fatigue	60.51	15.07	39	13006	929688	78801655
Pneumonia	58.70	15.07	238	12807	660008	79071335
Lymphocyte count decreased	54.89	15.07	52	12993	47237	79684106
Osteonecrosis of jaw	52.99	15.07	49	12996	43177	79688166
Altered state of consciousness	52.42	15.07	49	12996	43773	79687570
Spinal compression fracture	51.52	15.07	33	13012	16925	79714418
Anaemia	50.81	15.07	174	12871	444841	79286502
Disseminated intravascular coagulation	50.60	15.07	44	13001	35798	79695545
Malignant neoplasm progression	48.67	15.07	83	12962	135907	79595436
Toxicity to various agents	48.46	15.07	6	13039	421534	79309809
Drug-induced liver injury	42.12	15.07	53	12992	66064	79665279
Enterocolitis	41.04	15.07	27	13018	14485	79716858
Pneumonia bacterial	40.69	15.07	30	13015	19301	79712042
Liver disorder	39.83	15.07	54	12991	72363	79658980
Pyrexia	38.53	15.07	215	12830	678494	79052849
Diabetes mellitus	37.98	15.07	55	12990	78335	79653008
Femoral neck fracture	36.86	15.07	22	13023	9962	79721381
Pain	36.37	15.07	37	13008	703765	79027578
Plasma cell myeloma	36.02	15.07	44	13001	53215	79678128
Hypopituitarism	34.99	15.07	15	13030	3384	79727959
Male sexual dysfunction	34.75	15.07	8	13037	227	79731116
Febrile neutropenia	34.28	15.07	99	12946	230900	79500443
Erythema multiforme	34.05	15.07	26	13019	17625	79713718
Cardiac failure	34.04	15.07	77	12968	154765	79576578
Pneumonia aspiration	33.92	15.07	48	12997	66919	79664424
Joint swelling	33.42	15.07	4	13041	288642	79442701
Herpes zoster	32.22	15.07	56	12989	93027	79638316
Hypoalbuminaemia	29.76	15.07	26	13019	21271	79710072
Haemorrhage subcutaneous	27.10	15.07	14	13031	4795	79726548
Adrenal insufficiency	26.89	15.07	28	13017	28459	79702884
Concomitant disease aggravated	26.74	15.07	20	13025	13147	79718196
Drug hypersensitivity	26.48	15.07	8	13037	298908	79432435
Blood pressure decreased	25.91	15.07	53	12992	99413	79631930
Confusional state	25.60	15.07	10	13035	317987	79413356
Colon cancer	25.00	15.07	20	13025	14503	79716840
Toxic encephalopathy	24.63	15.07	18	13027	11422	79719921
Hyperuricaemia	24.13	15.07	18	13027	11781	79719562
Dyspnoea	23.93	15.07	67	12978	856958	78874385
Gastric ulcer haemorrhage	23.61	15.07	16	13029	9011	79722332
Ileus	23.38	15.07	25	13020	26186	79705157
Inappropriate antidiuretic hormone secretion	23.30	15.07	25	13020	26288	79705055
Aspartate aminotransferase increased	23.09	15.07	62	12983	138579	79592764
Hypocalcaemia	22.69	15.07	34	13011	49890	79681453
Peripheral swelling	22.50	15.07	8	13037	269609	79461734
Drug intolerance	21.76	15.07	8	13037	264111	79467232
Hypotension	21.74	15.07	24	13021	440293	79291050
Hypoglycaemia	21.74	15.07	50	12995	101544	79629799
Product dose omission issue	19.56	15.07	8	13037	247529	79483814
Spondylitic myelopathy	19.11	15.07	4	13041	72	79731271
Paraesthesia	19.08	15.07	3	13042	176320	79555023
Arthralgia	18.83	15.07	41	13004	571762	79159581
Swelling	18.83	15.07	6	13039	216705	79514638
Cerebellar infarction	18.79	15.07	10	13035	3637	79727706
Alopecia	17.45	15.07	8	13037	231347	79499996
Adrenocorticotropic hormone deficiency	17.24	15.07	7	13038	1378	79729965
Blood lactate dehydrogenase increased	16.84	15.07	26	13019	39144	79692199
Pemphigoid	16.18	15.07	16	13029	15299	79716044
Colitis ischaemic	16.14	15.07	16	13029	15343	79716000
Immune-mediated hypophysitis	15.70	15.07	4	13041	175	79731168
Hypersensitivity	15.65	15.07	12	13033	262227	79469116
Dyslalia	15.37	15.07	6	13039	1066	79730277
Anxiety	15.31	15.07	11	13034	248501	79482842
Diverticulum intestinal haemorrhagic	15.23	15.07	9	13036	4002	79727341

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03BA05	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Prevention of Vitamin B12 Deficiency	indication
Hypokalemia	contraindication	43339004
Gastrectomy	contraindication	53442002
Leber's optic atrophy	contraindication	58610003	DOID:705
Atrophic gastritis	contraindication	84568007	DOID:8929

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D03246	KEGG_DRUG
4024930	VUID
N0000179178	NUI
4024930	VANDF
CHEBI:28115	CHEBI
CHEMBL4297672	ChEMBL_ID
CHEMBL2359370	ChEMBL_ID
CHEMBL2448537	ChEMBL_ID
C019476	MESH_SUPPLEMENTAL_RECORD_UI
DB03614	DRUGBANK_ID
29421	RXNORM
210599	MMSL
295772	MMSL
29966	MMSL
338725	MMSL
361118	MMSL
60213	MMSL
NOCODE	MMSL
d05311	MMSL
007745	NDDF
259512006	SNOMEDCT_US
714678000	SNOMEDCT_US
C0065844	UMLSCUI
73415798	PUBCHEM_CID
3148	INN_ID
BR1SN1JS2W	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Organdrainex	HUMAN OTC DRUG LABEL	13	44911-0457	LIQUID	3 [hp_X]	ORAL	unapproved drug other	9 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED	HUMAN PRESCRIPTION DRUG LABEL	17	58154-107	TABLET, FILM COATED	8 ug	ORAL	unapproved drug other	8 sections
Vita-Rx Diabetic Vitamin	HUMAN PRESCRIPTION DRUG LABEL	14	65121-301	CAPSULE, GELATIN COATED	0.00 mg	ORAL	unapproved drug other	5 sections
Methaver	HUMAN PRESCRIPTION DRUG LABEL	5	69336-353	CAPSULE	2 mg	ORAL	unapproved drug other	13 sections
Vita-Rx Diabetic Vitamin	HUMAN PRESCRIPTION DRUG LABEL	14	69677-050	CAPSULE, GELATIN COATED	0.00 mg	ORAL	unapproved drug other	5 sections
B-Combo	HUMAN PRESCRIPTION DRUG LABEL	6	70104-110	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Lipovite	HUMAN PRESCRIPTION DRUG LABEL	13	70104-128	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
MIC B12	HUMAN PRESCRIPTION DRUG LABEL	4	70104-806	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Methylcobalamin	HUMAN PRESCRIPTION DRUG LABEL	1	70104-826	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Zyrexal	HUMAN PRESCRIPTION DRUG LABEL	8	72380-915	TABLET	1 mg	ORAL	unapproved drug other	8 sections
Folinex	HUMAN PRESCRIPTION DRUG LABEL	4	72380-916	CAPSULE	1 mg	ORAL	unapproved drug other	8 sections