mecobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4600 13422-55-4

Description:

MoleculeDescription

Synonyms:

  • mecobalamin
  • methycobal
  • methyl cobalamine
  • Methyl vitamin B12
  • methylcobalamin
  • methylcobaz
  • Molecular weight: 1344.40
  • Formula: C63H91CoN13O14P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 488.71
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
1.50 mg O
0.20 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 113.47 18.97 59 5168 32622 50567275
Platelet count decreased 96.12 18.97 81 5146 100645 50499252
Neutrophil count decreased 72.60 18.97 50 5177 45976 50553921
Interstitial lung disease 53.19 18.97 44 5183 53132 50546765
Osteonecrosis of jaw 45.84 18.97 33 5194 32493 50567404
Drug eruption 40.42 18.97 27 5200 23579 50576318
Renal impairment 39.98 18.97 44 5183 75617 50524280
Cerebral infarction 35.29 18.97 24 5203 21580 50578317
Upper respiratory tract inflammation 34.87 18.97 12 5215 2377 50597520
Anaemia 33.80 18.97 78 5149 252378 50347519
Erythema multiforme 33.27 18.97 17 5210 9033 50590864
White blood cell count decreased 29.12 18.97 47 5180 116675 50483222
Decreased appetite 29.01 18.97 64 5163 200859 50399038
Femoral neck fracture 27.33 18.97 14 5213 7476 50592421
Cardiac failure 26.74 18.97 36 5191 76004 50523893
Malignant neoplasm progression 26.67 18.97 34 5193 68090 50531807
Haemorrhage subcutaneous 26.08 18.97 10 5217 2691 50597206
Drug ineffective 25.97 18.97 28 5199 819305 49780592
Altered state of consciousness 25.87 18.97 20 5207 21890 50578007
Pain 25.67 18.97 14 5213 578889 50021008
Pyrexia 25.00 18.97 91 5136 380112 50219785
Hypoglycaemia 24.62 18.97 29 5198 53552 50546345
Pneumonia 24.40 18.97 90 5137 378311 50221586
Herpes zoster 24.11 18.97 33 5194 70753 50529144
Blood disorder 21.98 18.97 11 5216 5594 50594303
Febrile neutropenia 21.24 18.97 37 5190 97630 50502267
Fatigue 20.43 18.97 26 5201 707575 49892322
Mania 19.93 18.97 13 5214 10903 50588994
Pneumonia bacterial 19.23 18.97 11 5216 7298 50592599

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 120.38 19.03 90 4909 57628 29511900
Hepatic function abnormal 57.80 19.03 50 4949 39209 29530319
Platelet count decreased 54.29 19.03 77 4922 104595 29464933
Cerebral infarction 39.51 19.03 33 4966 24642 29544886
Altered state of consciousness 39.09 19.03 30 4969 19859 29549669
Upper respiratory tract inflammation 37.47 19.03 13 4986 1607 29567921
Liver disorder 36.15 19.03 33 4966 27716 29541812
Renal impairment 33.79 19.03 54 4945 81279 29488249
Fatigue 30.55 19.03 8 4991 316813 29252715
Hypopituitarism 29.21 19.03 11 4988 1719 29567809
Neutrophil count decreased 28.58 19.03 36 4963 43531 29525997
Disseminated intravascular coagulation 28.47 19.03 25 4974 19955 29549573
Pneumonia 26.95 19.03 116 4883 320056 29249472
Drug-induced liver injury 26.74 19.03 25 4974 21630 29547898
Malignant neoplasm progression 26.59 19.03 46 4953 73813 29495715
Diabetes mellitus 26.26 19.03 33 4966 39798 29529730
Male sexual dysfunction 23.97 19.03 6 4993 236 29569292
Decreased appetite 22.98 19.03 65 4934 145277 29424251
Drug ineffective 22.76 19.03 17 4982 363153 29206375
Enterocolitis 22.42 19.03 14 4985 6652 29562876
Pneumonia aspiration 21.96 19.03 29 4970 36708 29532820
White blood cell count decreased 21.44 19.03 45 4954 83317 29486211
Lymphocyte count decreased 21.42 19.03 21 4978 19250 29550278
Drug eruption 20.04 19.03 19 4980 16722 29552806

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 160.24 15.89 131 10504 97601 64390496
Hepatic function abnormal 153.71 15.89 108 10527 64205 64423892
Platelet count decreased 151.12 15.89 161 10474 167550 64320547
Neutrophil count decreased 97.09 15.89 89 10546 77107 64410990
Cerebral infarction 71.35 15.89 57 10578 40987 64447110
Renal impairment 68.29 15.89 97 10538 134920 64353177
Upper respiratory tract inflammation 67.93 15.89 25 10610 3757 64484340
Altered state of consciousness 54.16 15.89 47 10588 37855 64450242
Drug eruption 54.05 15.89 46 10589 36090 64452007
Fatigue 52.87 15.89 29 10606 748701 63739396
White blood cell count decreased 51.68 15.89 93 10542 157744 64330353
Drug ineffective 50.58 15.89 39 10596 840208 63647889
Disseminated intravascular coagulation 48.01 15.89 41 10594 32307 64455790
Decreased appetite 47.62 15.89 127 10508 281162 64206935
Pneumonia 47.55 15.89 200 10435 559376 63928721
Malignant neoplasm progression 46.90 15.89 74 10561 112797 64375300
Osteonecrosis of jaw 46.33 15.89 44 10591 39781 64448316
Enterocolitis 40.38 15.89 25 10610 11993 64476104
Toxicity to various agents 40.27 15.89 6 10629 363507 64124590
Liver disorder 38.96 15.89 46 10589 53305 64434792
Drug-induced liver injury 38.01 15.89 43 10592 47600 64440497
Anaemia 34.96 15.89 139 10496 378541 64109556
Erythema multiforme 34.30 15.89 25 10610 15676 64472421
Plasma cell myeloma 34.09 15.89 40 10595 46035 64442062
Pneumonia aspiration 33.55 15.89 45 10590 59226 64428871
Spinal compression fracture 33.36 15.89 24 10611 14751 64473346
Pyrexia 33.07 15.89 180 10455 558464 63929633
Femoral neck fracture 31.49 15.89 19 10616 8705 64479392
Hypopituitarism 31.44 15.89 13 10622 2660 64485437
Lymphocyte count decreased 31.22 15.89 36 10599 40663 64447434
Febrile neutropenia 30.97 15.89 84 10551 187573 64300524
Pneumonia bacterial 30.73 15.89 23 10612 15012 64473085
Herpes zoster 30.26 15.89 50 10585 79137 64408960
Haemorrhage subcutaneous 28.29 15.89 14 10621 4347 64483750
Pain 28.07 15.89 30 10605 553481 63934616
Cardiac failure 27.85 15.89 65 10570 132308 64355789
Confusional state 27.36 15.89 5 10630 261139 64226958
Toxic encephalopathy 26.99 15.89 18 10617 9797 64478300
Diabetes mellitus 26.79 15.89 43 10592 66431 64421666
Inappropriate antidiuretic hormone secretion 26.63 15.89 25 10610 22264 64465833
Male sexual dysfunction 25.72 15.89 6 10629 179 64487918
Drug hypersensitivity 23.97 15.89 5 10630 237810 64250287
Hypoalbuminaemia 23.40 15.89 21 10614 17653 64470444
Hypotension 21.19 15.89 19 10616 380955 64107142
Gastric ulcer haemorrhage 20.17 15.89 14 10621 8129 64479968
Concomitant disease aggravated 19.98 15.89 16 10619 11526 64476571
Dyspnoea 19.96 15.89 57 10578 718617 63769480
Hypoglycaemia 19.84 15.89 45 10590 89847 64398250
Cerebellar infarction 19.61 15.89 10 10625 3309 64484788
Prescribed underdose 19.24 15.89 19 10616 17996 64470101
Colon cancer 18.60 15.89 16 10619 12723 64475374
Blood pressure decreased 17.76 15.89 42 10593 86157 64401940
Hyperuricaemia 17.37 15.89 14 10621 10177 64477920
Drug intolerance 16.91 15.89 5 10630 187987 64300110
Hypocalcaemia 16.80 15.89 27 10608 41726 64446371
Peripheral swelling 16.36 15.89 7 10628 209146 64278951
Product dose omission issue 16.08 15.89 6 10629 194741 64293356

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03BA05 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Prevention of Vitamin B12 Deficiency indication
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Atrophic gastritis contraindication 84568007 DOID:8929




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03246 KEGG_DRUG
4024930 VUID
N0000179178 NUI
4024930 VANDF
CHEBI:28115 CHEBI
CHEMBL4297672 ChEMBL_ID
CHEMBL2359370 ChEMBL_ID
CHEMBL2448537 ChEMBL_ID
C019476 MESH_SUPPLEMENTAL_RECORD_UI
DB03614 DRUGBANK_ID
73415798 PUBCHEM_CID
29421 RXNORM
210599 MMSL
295772 MMSL
29966 MMSL
338725 MMSL
60213 MMSL
NOCODE MMSL
d05311 MMSL
007745 NDDF
259512006 SNOMEDCT_US
714678000 SNOMEDCT_US
C0065844 UMLSCUI
3148 INN_ID
BR1SN1JS2W UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Organdrainex HUMAN OTC DRUG LABEL 13 44911-0457 LIQUID 3 [hp_X] ORAL unapproved drug other 9 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED HUMAN PRESCRIPTION DRUG LABEL 17 58154-107 TABLET, FILM COATED 8 ug ORAL unapproved drug other 8 sections
Vita-Rx Diabetic Vitamin HUMAN PRESCRIPTION DRUG LABEL 14 65121-301 CAPSULE, GELATIN COATED 0.00 mg ORAL unapproved drug other 5 sections
Methaver HUMAN PRESCRIPTION DRUG LABEL 5 69336-353 CAPSULE 2 mg ORAL unapproved drug other 13 sections
Vita-Rx Diabetic Vitamin HUMAN PRESCRIPTION DRUG LABEL 14 69677-050 CAPSULE, GELATIN COATED 0.00 mg ORAL unapproved drug other 5 sections
B-Combo HUMAN PRESCRIPTION DRUG LABEL 6 70104-110 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
MIC B12 HUMAN PRESCRIPTION DRUG LABEL 4 70104-806 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Methylcobalamin HUMAN PRESCRIPTION DRUG LABEL 1 70104-826 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Zyrexal HUMAN PRESCRIPTION DRUG LABEL 8 72380-915 TABLET 1 mg ORAL unapproved drug other 8 sections
Folinex HUMAN PRESCRIPTION DRUG LABEL 4 72380-916 CAPSULE 1 mg ORAL unapproved drug other 8 sections