mecobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4600 13422-55-4

Description:

MoleculeDescription

Synonyms:

  • mecobalamin
  • methycobal
  • methyl cobalamine
  • Methyl vitamin B12
  • methylcobalamin
  • methylcobaz
  • Molecular weight: 1344.40
  • Formula: C63H91CoN13O14P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 488.71
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
1.50 mg O
0.20 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 130.76 18.63 67 6289 37075 63445591
Platelet count decreased 120.99 18.63 97 6259 116025 63366641
Neutrophil count decreased 97.29 18.63 64 6292 56342 63426324
Interstitial lung disease 62.85 18.63 51 6305 61857 63420809
Osteonecrosis of jaw 51.34 18.63 36 6320 35087 63447579
Renal impairment 50.89 18.63 53 6303 88302 63394364
White blood cell count decreased 47.73 18.63 64 6292 139040 63343626
Anaemia 47.41 18.63 96 6260 293334 63189332
Drug eruption 45.68 18.63 31 6325 28663 63454003
Cerebral infarction 40.88 18.63 27 6329 23866 63458800
Pain 35.45 18.63 15 6341 740613 62742053
Erythema multiforme 34.75 18.63 18 6338 10151 63472515
Upper respiratory tract inflammation 34.60 18.63 12 6344 2511 63480155
Pyrexia 34.22 18.63 114 6242 470364 63012302
Drug ineffective 32.78 18.63 34 6322 1044731 62437935
Cardiac failure 30.52 18.63 41 6315 89101 63393565
Malignant neoplasm progression 30.01 18.63 39 6317 82082 63400584
Pneumonia 29.99 18.63 107 6249 456660 63026006
Decreased appetite 29.09 18.63 72 6284 250980 63231686
Lymphocyte count decreased 28.74 18.63 24 6332 30233 63452433
Altered state of consciousness 28.17 18.63 22 6334 25208 63457458
Hypoglycaemia 27.56 18.63 32 6324 60033 63422633
Spinal compression fracture 26.53 18.63 17 6339 14266 63468400
Femoral neck fracture 26.04 18.63 14 6342 8509 63474157
Febrile neutropenia 25.63 18.63 44 6312 118405 63364261
Haemorrhage subcutaneous 25.42 18.63 10 6346 2973 63479693
Herpes zoster 25.33 18.63 36 6320 82426 63400240
Pneumonia bacterial 24.66 18.63 14 6342 9451 63473215
Fatigue 24.46 18.63 32 6324 887996 62594670
Aspartate aminotransferase increased 24.25 18.63 37 6319 90240 63392426
Blood pressure decreased 23.94 18.63 31 6325 64991 63417675
Aortic aneurysm rupture 22.25 18.63 6 6350 540 63482126
Blood disorder 20.34 18.63 11 6345 6760 63475906
Disseminated intravascular coagulation 19.95 18.63 16 6340 19035 63463631
Osteomyelitis 19.42 18.63 18 6338 26002 63456664
Liver disorder 18.83 18.63 25 6331 53662 63429004
Mania 18.82 18.63 13 6343 12354 63470312

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 115.76 17.51 95 6204 65187 34885445
Platelet count decreased 70.85 17.51 97 6202 119620 34831012
Hepatic function abnormal 63.15 17.51 57 6242 44306 34906326
Cerebral infarction 42.48 17.51 37 6262 27418 34923214
Decreased appetite 40.31 17.51 91 6208 166301 34784331
Drug-induced liver injury 37.03 17.51 35 6264 28797 34921835
Upper respiratory tract inflammation 35.72 17.51 13 6286 1731 34948901
Diabetes mellitus 35.52 17.51 43 6256 46830 34903802
Liver disorder 34.85 17.51 36 6263 32961 34917671
Fatigue 34.43 17.51 12 6287 370641 34579991
Neutrophil count decreased 34.12 17.51 44 6255 51060 34899572
Altered state of consciousness 33.70 17.51 30 6269 22863 34927769
Renal impairment 32.74 17.51 60 6239 94453 34856179
Hypopituitarism 32.32 17.51 13 6286 2269 34948363
Male sexual dysfunction 32.25 17.51 8 6291 284 34950348
White blood cell count decreased 31.07 17.51 59 6240 95386 34855246
Disseminated intravascular coagulation 30.95 17.51 28 6271 21788 34928844
Pneumonia 30.18 17.51 137 6162 362490 34588142
Drug ineffective 29.00 17.51 24 6275 456727 34493905
Spinal compression fracture 28.24 17.51 17 6282 7099 34943533
Lymphocyte count decreased 28.17 17.51 27 6272 22595 34928037
Pneumonia bacterial 24.66 17.51 19 6280 11853 34938779
Enterocolitis 23.92 17.51 16 6283 8010 34942622
Toxicity to various agents 23.39 17.51 4 6295 200358 34750274
Drug eruption 23.36 17.51 23 6276 19875 34930757
Malignant neoplasm progression 23.35 17.51 50 6249 87996 34862636
Colon cancer 22.88 17.51 16 6283 8605 34942027
Pneumonia aspiration 20.38 17.51 31 6268 41872 34908760
Pemphigoid 18.28 17.51 14 6285 8652 34941980
Adrenal insufficiency 17.93 17.51 17 6282 14030 34936602

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 194.90 15.07 197 12848 194467 79536876
Hepatic function abnormal 176.11 15.07 123 12922 72984 79658359
Interstitial lung disease 169.09 15.07 143 12902 112457 79618886
Neutrophil count decreased 126.17 15.07 112 12933 93847 79637496
White blood cell count decreased 81.24 15.07 125 12920 188163 79543180
Cerebral infarction 81.05 15.07 64 12981 45612 79685731
Renal impairment 78.48 15.07 112 12933 157671 79573672
Upper respiratory tract inflammation 66.54 15.07 25 13020 4010 79727333
Drug ineffective 65.57 15.07 49 12996 1080864 78650479
Decreased appetite 65.42 15.07 161 12884 342257 79389086
Drug eruption 62.17 15.07 54 12991 43881 79687462
Fatigue 60.51 15.07 39 13006 929688 78801655
Pneumonia 58.70 15.07 238 12807 660008 79071335
Lymphocyte count decreased 54.89 15.07 52 12993 47237 79684106
Osteonecrosis of jaw 52.99 15.07 49 12996 43177 79688166
Altered state of consciousness 52.42 15.07 49 12996 43773 79687570
Spinal compression fracture 51.52 15.07 33 13012 16925 79714418
Anaemia 50.81 15.07 174 12871 444841 79286502
Disseminated intravascular coagulation 50.60 15.07 44 13001 35798 79695545
Malignant neoplasm progression 48.67 15.07 83 12962 135907 79595436
Toxicity to various agents 48.46 15.07 6 13039 421534 79309809
Drug-induced liver injury 42.12 15.07 53 12992 66064 79665279
Enterocolitis 41.04 15.07 27 13018 14485 79716858
Pneumonia bacterial 40.69 15.07 30 13015 19301 79712042
Liver disorder 39.83 15.07 54 12991 72363 79658980
Pyrexia 38.53 15.07 215 12830 678494 79052849
Diabetes mellitus 37.98 15.07 55 12990 78335 79653008
Femoral neck fracture 36.86 15.07 22 13023 9962 79721381
Pain 36.37 15.07 37 13008 703765 79027578
Plasma cell myeloma 36.02 15.07 44 13001 53215 79678128
Hypopituitarism 34.99 15.07 15 13030 3384 79727959
Male sexual dysfunction 34.75 15.07 8 13037 227 79731116
Febrile neutropenia 34.28 15.07 99 12946 230900 79500443
Erythema multiforme 34.05 15.07 26 13019 17625 79713718
Cardiac failure 34.04 15.07 77 12968 154765 79576578
Pneumonia aspiration 33.92 15.07 48 12997 66919 79664424
Joint swelling 33.42 15.07 4 13041 288642 79442701
Herpes zoster 32.22 15.07 56 12989 93027 79638316
Hypoalbuminaemia 29.76 15.07 26 13019 21271 79710072
Haemorrhage subcutaneous 27.10 15.07 14 13031 4795 79726548
Adrenal insufficiency 26.89 15.07 28 13017 28459 79702884
Concomitant disease aggravated 26.74 15.07 20 13025 13147 79718196
Drug hypersensitivity 26.48 15.07 8 13037 298908 79432435
Blood pressure decreased 25.91 15.07 53 12992 99413 79631930
Confusional state 25.60 15.07 10 13035 317987 79413356
Colon cancer 25.00 15.07 20 13025 14503 79716840
Toxic encephalopathy 24.63 15.07 18 13027 11422 79719921
Hyperuricaemia 24.13 15.07 18 13027 11781 79719562
Dyspnoea 23.93 15.07 67 12978 856958 78874385
Gastric ulcer haemorrhage 23.61 15.07 16 13029 9011 79722332
Ileus 23.38 15.07 25 13020 26186 79705157
Inappropriate antidiuretic hormone secretion 23.30 15.07 25 13020 26288 79705055
Aspartate aminotransferase increased 23.09 15.07 62 12983 138579 79592764
Hypocalcaemia 22.69 15.07 34 13011 49890 79681453
Peripheral swelling 22.50 15.07 8 13037 269609 79461734
Drug intolerance 21.76 15.07 8 13037 264111 79467232
Hypotension 21.74 15.07 24 13021 440293 79291050
Hypoglycaemia 21.74 15.07 50 12995 101544 79629799
Product dose omission issue 19.56 15.07 8 13037 247529 79483814
Spondylitic myelopathy 19.11 15.07 4 13041 72 79731271
Paraesthesia 19.08 15.07 3 13042 176320 79555023
Arthralgia 18.83 15.07 41 13004 571762 79159581
Swelling 18.83 15.07 6 13039 216705 79514638
Cerebellar infarction 18.79 15.07 10 13035 3637 79727706
Alopecia 17.45 15.07 8 13037 231347 79499996
Adrenocorticotropic hormone deficiency 17.24 15.07 7 13038 1378 79729965
Blood lactate dehydrogenase increased 16.84 15.07 26 13019 39144 79692199
Pemphigoid 16.18 15.07 16 13029 15299 79716044
Colitis ischaemic 16.14 15.07 16 13029 15343 79716000
Immune-mediated hypophysitis 15.70 15.07 4 13041 175 79731168
Hypersensitivity 15.65 15.07 12 13033 262227 79469116
Dyslalia 15.37 15.07 6 13039 1066 79730277
Anxiety 15.31 15.07 11 13034 248501 79482842
Diverticulum intestinal haemorrhagic 15.23 15.07 9 13036 4002 79727341

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03BA05 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Prevention of Vitamin B12 Deficiency indication
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Atrophic gastritis contraindication 84568007 DOID:8929




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03246 KEGG_DRUG
4024930 VUID
N0000179178 NUI
4024930 VANDF
CHEBI:28115 CHEBI
CHEMBL4297672 ChEMBL_ID
CHEMBL2359370 ChEMBL_ID
CHEMBL2448537 ChEMBL_ID
C019476 MESH_SUPPLEMENTAL_RECORD_UI
DB03614 DRUGBANK_ID
29421 RXNORM
210599 MMSL
295772 MMSL
29966 MMSL
338725 MMSL
361118 MMSL
60213 MMSL
NOCODE MMSL
d05311 MMSL
007745 NDDF
259512006 SNOMEDCT_US
714678000 SNOMEDCT_US
C0065844 UMLSCUI
73415798 PUBCHEM_CID
3148 INN_ID
BR1SN1JS2W UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Organdrainex HUMAN OTC DRUG LABEL 13 44911-0457 LIQUID 3 [hp_X] ORAL unapproved drug other 9 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED HUMAN PRESCRIPTION DRUG LABEL 17 58154-107 TABLET, FILM COATED 8 ug ORAL unapproved drug other 8 sections
Vita-Rx Diabetic Vitamin HUMAN PRESCRIPTION DRUG LABEL 14 65121-301 CAPSULE, GELATIN COATED 0.00 mg ORAL unapproved drug other 5 sections
Methaver HUMAN PRESCRIPTION DRUG LABEL 5 69336-353 CAPSULE 2 mg ORAL unapproved drug other 13 sections
Vita-Rx Diabetic Vitamin HUMAN PRESCRIPTION DRUG LABEL 14 69677-050 CAPSULE, GELATIN COATED 0.00 mg ORAL unapproved drug other 5 sections
B-Combo HUMAN PRESCRIPTION DRUG LABEL 6 70104-110 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
MIC B12 HUMAN PRESCRIPTION DRUG LABEL 4 70104-806 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Methylcobalamin HUMAN PRESCRIPTION DRUG LABEL 1 70104-826 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Zyrexal HUMAN PRESCRIPTION DRUG LABEL 8 72380-915 TABLET 1 mg ORAL unapproved drug other 8 sections
Folinex HUMAN PRESCRIPTION DRUG LABEL 4 72380-916 CAPSULE 1 mg ORAL unapproved drug other 8 sections