calcium citrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4479 7693-13-2

Description:

MoleculeDescription

Synonyms:

  • calcium citrate
A colorless crystalline or white powdery organic, tricarboxylic acid occurring in plants, especially citrus fruits, and used as a flavoring agent, as an antioxidant in foods, and as a sequestrating agent. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
  • Molecular weight: 498.43
  • Formula: C12H10Ca3O14
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 140.62
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Recalled product 181.55 14.61 41 8163 1362 63479456
Hypocalcaemia 69.44 14.61 46 8158 31667 63449151
Macular degeneration 52.49 14.61 35 8169 24341 63456477
Gouty tophus 47.59 14.61 10 8194 235 63480583
Osteocalcin decreased 33.92 14.61 6 8198 54 63480764
Atypical femur fracture 25.79 14.61 13 8191 5359 63475459
Muscle spasms 25.66 14.61 60 8144 156090 63324728
Chronic sinusitis 21.93 14.61 16 8188 12827 63467991
Toxicity to various agents 21.90 14.61 3 8201 247247 63233571
Dyspepsia 21.02 14.61 43 8161 102153 63378665
Paraesthesia oral 20.12 14.61 18 8186 19238 63461580
Osteoarthritis 19.47 14.61 40 8164 95303 63385515
Osteomalacia 18.89 14.61 6 8198 739 63480079
Fatigue 17.45 14.61 183 8021 887845 62592973
Diarrhoea 16.76 14.61 153 8051 715213 62765605
Spinal osteoarthritis 16.65 14.61 15 8189 16171 63464647
Procedural pain 16.54 14.61 17 8187 21552 63459266
Contraindicated product administered 16.36 14.61 4 8200 217644 63263174
Product dose omission issue 15.79 14.61 66 8138 234247 63246571
Blood calcium abnormal 15.77 14.61 6 8198 1262 63479556
Systemic lupus erythematosus 15.39 14.61 4 8200 208914 63271904
Maternal exposure during pregnancy 14.78 14.61 5 8199 220057 63260761

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Polyomavirus-associated nephropathy 35.89 22.14 12 2049 3832 34951038
Mycotic allergy 29.97 22.14 7 2054 601 34954269
Mite allergy 28.97 22.14 7 2054 695 34954175
Spirometry abnormal 28.75 22.14 7 2054 717 34954153
Dust allergy 27.19 22.14 7 2054 899 34953971
Conjunctivitis allergic 25.42 22.14 7 2054 1163 34953707

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Recalled product 61.14 15.52 15 7874 939 79735560
Gouty tophus 44.58 15.52 10 7879 423 79736076
Osteocalcin decreased 36.04 15.52 6 7883 49 79736450
Hypocalcaemia 32.78 15.52 32 7857 49892 79686607
Atypical femur fracture 29.54 15.52 13 7876 5176 79731323
Fatigue 28.05 15.52 172 7717 929555 78806944
Macular degeneration 27.72 15.52 16 7873 11280 79725219
Chronic sinusitis 25.61 15.52 16 7873 13010 79723489
Polyomavirus-associated nephropathy 25.41 15.52 12 7877 5615 79730884
Toxicity to various agents 24.15 15.52 6 7883 421534 79314965
Dust allergy 23.87 15.52 8 7881 1528 79734971
Spirometry abnormal 23.21 15.52 7 7882 952 79735547
Mite allergy 21.49 15.52 7 7882 1223 79735276
Paraesthesia oral 21.21 15.52 17 7872 20454 79716045
Dyspepsia 20.77 15.52 38 7851 108649 79627850
Product dose omission issue 20.17 15.52 62 7827 247475 79489024
Mycotic allergy 20.04 15.52 7 7882 1512 79734987
Procedural pain 19.42 15.52 17 7872 23067 79713432
Conjunctivitis allergic 19.19 15.52 7 7882 1713 79734786
Drug interaction 17.01 15.52 10 7879 415173 79321326
Full blood count abnormal 16.19 15.52 20 7869 40454 79696045
Fall 15.76 15.52 92 7797 487537 79248962

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A12AA13 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
CALCIUM
Calcium
MeSH PA D005503 Food Additives

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypocalcemia indication 5291005
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Diarrhea contraindication 62315008
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypercalciuria contraindication 71938000
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00933 KEGG_DRUG
4019484 VUID
N0000147604 NUI
5785-44-4 SECONDARY_CAS_RN
4019479 VANDF
4019484 VANDF
CHEMBL2106123 ChEMBL_ID
DB11093 DRUGBANK_ID
47613 RXNORM
16535 MMSL
4334 MMSL
6782 MMSL
d03866 MMSL
003645 NDDF
C0108101 UMLSCUI
D019355 MESH_DESCRIPTOR_UI
13136 PUBCHEM_CID
MLM29U2X85 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 104 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 104 mg ORAL unapproved drug other 10 sections
Citranatal Harmony 2.1 HUMAN PRESCRIPTION DRUG LABEL 2 0178-0797 CAPSULE, GELATIN COATED 104 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 104 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 100 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 100 mg ORAL Unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 159 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 159 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 160 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 124 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 125 mg ORAL Unapproved drug other 9 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 62 mg ORAL unapproved drug other 10 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 62 mg ORAL unapproved drug other 10 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 125 mg ORAL Unapproved drug other 11 sections
Prenaissance Plus HUMAN PRESCRIPTION DRUG LABEL 8 42192-343 CAPSULE, LIQUID FILLED 100 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Dairy Allergen Mix HUMAN OTC DRUG LABEL 38 43742-1277 LIQUID 6 [hp_C] ORAL unapproved drug other 9 sections
INATAL Ultra HUMAN PRESCRIPTION DRUG LABEL 16 63044-154 TABLET, COATED 200 mg ORAL Unapproved drug other 10 sections