trisodium citrate dihydrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4474	6132-04-3

Description:

Molecule	Description
Synonyms: trisodium citrate dihydrate sodium citrate dihydrate	Molecular weight: 294.10 Formula: C6H9Na3O9 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 140.62 ALOGS: ROTB: None

Molecule

Description

Synonyms:

trisodium citrate dihydrate
sodium citrate dihydrate

Molecular weight: 294.10
Formula: C6H9Na3O9
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 140.62
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paraesthesia	12900.52	135.90	3836	18112	153130	63313944
Feeling hot	7719.02	135.90	2025	19923	48329	63418745
Pallor	7664.38	135.90	1825	20123	28743	63438331
Hyperhidrosis	4185.97	135.90	1515	20433	106321	63360753
Thirst	4013.96	135.90	936	21012	13105	63453969
Dizziness	3533.79	135.90	2039	19909	427886	63039188
Nausea	2344.74	135.90	2077	19871	852394	62614680
Dysgeusia	2026.44	135.90	716	21232	45994	63421080
Vision blurred	2007.38	135.90	855	21093	91069	63376005
Asthenia	1131.46	135.90	981	20967	382623	63084451
Dyspepsia	921.79	135.90	521	21427	101675	63365399
Restlessness	915.13	135.90	354	21594	29099	63437975
Chills	748.55	135.90	473	21475	112905	63354169
Injection site haematoma	504.81	135.90	157	21791	6675	63460399
Fatigue	221.12	135.90	25	21923	888003	62579071
Drug ineffective	218.56	135.90	48	21900	1044717	62422357
Tetany	195.23	135.90	57	21891	1944	63465130
Diarrhoea	186.00	135.90	17	21931	715349	62751725
Neck pain	175.84	135.90	164	21784	69154	63397920
Palpitations	152.03	135.90	191	21757	112579	63354495
Rash	146.51	135.90	13	21935	560858	62906216
Dyspnoea	144.87	135.90	27	21921	661286	62805788
Arthralgia	136.62	135.90	18	21930	569692	62897382

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paraesthesia	4968.82	152.84	1495	10189	62677	34882570
Feeling hot	2417.16	152.84	660	11024	18712	34926535
Pallor	2216.18	152.84	655	11029	24825	34920422
Thirst	1452.54	152.84	367	11317	7528	34937719
Hyperhidrosis	1361.95	152.84	607	11077	75085	34870162
Dizziness	956.17	152.84	693	10991	217828	34727419
Nausea	883.80	152.84	794	10890	339114	34606133
Dysgeusia	855.42	152.84	324	11360	26173	34919074
Vision blurred	545.34	152.84	278	11406	45685	34899562
Appendicolith	403.78	152.84	139	11545	8462	34936785
Restlessness	348.57	152.84	170	11514	25312	34919935
Dyspepsia	338.60	152.84	188	11496	36544	34908703
Appendicitis	330.32	152.84	139	11545	14668	34930579
Injection site haematoma	327.52	152.84	83	11601	1702	34943545
Chills	273.72	152.84	222	11462	80821	34864426
Cardiogenic shock	255.47	152.84	140	11544	26478	34918769
Stress	240.99	152.84	141	11543	30206	34915041
Ascites	222.28	152.84	157	11527	46414	34898833
Asthenia	215.65	152.84	331	11353	244920	34700327
Ventricular fibrillation	177.80	152.84	105	11579	22849	34922398
Blood phosphorus increased	160.51	152.84	69	11615	7652	34937595
Abdominal pain	156.40	152.84	230	11454	163388	34781859
Abdominal distension	155.79	152.84	140	11544	58352	34886895

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paraesthesia	17990.10	118.02	5331	28091	170992	79539974
Feeling hot	9996.91	118.02	2684	30738	57050	79653916
Pallor	9464.42	118.02	2479	30943	47583	79663383
Hyperhidrosis	5449.29	118.02	2121	31301	149371	79561595
Thirst	5393.64	118.02	1302	32120	17317	79693649
Dizziness	4452.75	118.02	2729	30693	523712	79187254
Nausea	3271.03	118.02	2869	30553	954327	78756639
Dysgeusia	2917.03	118.02	1039	32383	56138	79654828
Vision blurred	2596.71	118.02	1132	32290	104766	79606200
Asthenia	1291.56	118.02	1309	32113	510380	79200586
Dyspepsia	1289.39	118.02	709	32713	107978	79602988
Restlessness	1224.23	118.02	524	32898	45968	79664998
Chills	1002.24	118.02	695	32727	159539	79551427
Injection site haematoma	909.12	118.02	240	33182	4587	79706379
Appendicolith	369.67	118.02	138	33284	8413	79702553
Tetany	304.19	118.02	90	33332	2638	79708328
Drug ineffective	299.76	118.02	48	33374	1080865	78630101
Fatigue	284.69	118.02	30	33392	929697	78781269
Appendicitis	252.15	118.02	138	33284	20656	79690310
Diarrhoea	239.56	118.02	41	33381	880448	78830518
Neck pain	227.39	118.02	214	33208	75203	79635763
Palpitations	189.58	118.02	249	33173	126361	79584605
Pyrexia	181.32	118.02	33	33389	678676	79032290
Abdominal pain	181.07	118.02	460	32962	389109	79321857
Arthralgia	175.79	118.02	18	33404	571785	79139181
Rash	175.77	118.02	19	33403	578339	79132627
Pneumonia	174.44	118.02	33	33389	660213	79050753
Cardiogenic shock	166.31	118.02	139	33283	41775	79669191
Fall	148.15	118.02	16	33406	487613	79223353
Dyspnoea	145.72	118.02	90	33332	856935	78854031
Acute kidney injury	136.99	118.02	26	33396	519378	79191588
Toxicity to various agents	135.55	118.02	11	33411	421529	79289437
Weight decreased	134.47	118.02	3	33419	355195	79355771
Drug interaction	130.31	118.02	12	33410	415171	79295795
Blood phosphorus increased	129.10	118.02	70	33352	10277	79700689
Ascites	124.65	118.02	156	33266	75406	79635560
Ventricular fibrillation	122.76	118.02	104	33318	31822	79679144
Decreased appetite	122.02	118.02	5	33417	342413	79368553

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000925	Anticoagulants
MeSH PA	D002021	Buffers
MeSH PA	D005503	Food Additives
MeSH PA	D005520	Food Preservatives
MeSH PA	D006401	Hematologic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Renal tubular acidosis	off-label use	1776003	DOID:14219
Cystinuria	off-label use	85020001	DOID:9266
Calcium renal calculus	off-label use	427649000
Cystine Renal Calculi	off-label use
Calcium Oxalate Renal Calculi	off-label use

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	7		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	4.41		CHEMBL

External reference:

ID	Source
4017925	VUID
N0000146276	NUI
4017925	VANDF
CHEMBL1355	ChEMBL_ID
B22547B95K	UNII
221163	RXNORM
5480	MMSL
72098	MMSL
007629	NDDF
C0724696	UMLSCUI
D000077559	MESH_DESCRIPTOR_UI
71474	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CPDA-1	HUMAN PRESCRIPTION DRUG LABEL	5	0942-6305	SOLUTION	1.66 g	INTRAVENOUS	NDA	2 sections
CPDA-1	HUMAN PRESCRIPTION DRUG LABEL	5	0942-6307	SOLUTION	1.84 g	INTRAVENOUS	NDA	2 sections
CPDA-1	HUMAN PRESCRIPTION DRUG LABEL	5	0942-6308	SOLUTION	1.84 g	INTRAVENOUS	NDA	2 sections
CPDA-1	HUMAN PRESCRIPTION DRUG LABEL	5	0942-6312	SOLUTION	1.84 g	INTRAVENOUS	NDA	2 sections
CPDA-1	Human Prescription Drug Label	5	0942-6316	SOLUTION	1.84 g	INTRAVENOUS	NDA	2 sections
CPDA-1	HUMAN PRESCRIPTION DRUG LABEL	5	0942-6320	SOLUTION	1.84 g	INTRAVENOUS	NDA	2 sections
CPDA-1	HUMAN PRESCRIPTION DRUG LABEL	5	0942-6322	SOLUTION	1.66 g	INTRAVENOUS	NDA	2 sections
CPDA-1	HUMAN PRESCRIPTION DRUG LABEL	5	0942-6326	SOLUTION	1.84 g	INTRAVENOUS	NDA	2 sections
ACD Blood-Pack Units (PL 146 Plastic)	Human Prescription Drug Label	3	0942-9001	SOLUTION	1.48 g	INTRAVENOUS	NDA	2 sections
ACD Blood-Pack Units (PL 146 Plastic)	Human Prescription Drug Label	3	0942-9001	SOLUTION	1.48 g	INTRAVENOUS	NDA	2 sections
Anticoagulant Citrate Phosphate Dextrose (CPD) Blood-Pack Units in PL 146 Plastic	Human Prescription Drug Label	4	0942-9201	SOLUTION	921 mg	INTRAVENOUS	NDA	2 sections
Anticoagulant Citrate Phosphate Dextrose (CPD) Blood-Pack Units in PL 146 Plastic	Human Prescription Drug Label	4	0942-9201	SOLUTION	921 mg	INTRAVENOUS	NDA	2 sections
Anticoagulant Citrate Phosphate Dextrose (CPD) Blood-Pack Units in PL 146 Plastic	Human Prescription Drug Label	4	0942-9202	SOLUTION	1.66 g	INTRAVENOUS	NDA	2 sections
Anticoagulant Citrate Phosphate Dextrose (CPD) Blood-Pack Units in PL 146 Plastic	Human Prescription Drug Label	4	0942-9202	SOLUTION	1.66 g	INTRAVENOUS	NDA	2 sections
CPD	HUMAN PRESCRIPTION DRUG LABEL	4	0942-9206	SOLUTION	1.66 g	INTRAVENOUS	NDA	2 sections
CPDA-1	HUMAN PRESCRIPTION DRUG LABEL	5	0942-9393	SOLUTION	1.84 g	INTRAVENOUS	NDA	2 sections
CPDA-1	Human Prescription Drug Label	5	0942-9394	SOLUTION	1.66 g	INTRAVENOUS	NDA	2 sections
CPDA-1	Human Prescription Drug Label	5	0942-9394	SOLUTION	1.66 g	INTRAVENOUS	NDA	2 sections
CPDA-1	HUMAN PRESCRIPTION DRUG LABEL	5	0942-9398	SOLUTION	1.66 g	INTRAVENOUS	NDA	2 sections
Sodium Citrate Blood-Pack Units, (PL 146 Plastic)	HUMAN PRESCRIPTION DRUG LABEL	1	0942-9504	SOLUTION	4 g	INTRAVENOUS	NDA	2 sections
Sodium Citrate Blood-Pack Units, (PL 146 Plastic)	HUMAN PRESCRIPTION DRUG LABEL	1	0942-9505	SOLUTION	4 g	INTRAVENOUS	NDA	2 sections
Sodium Citrate Blood-Pack Units, (PL 146 Plastic)	Human Prescription Drug Label	1	0942-9506	SOLUTION	4 g	INTRAVENOUS	NDA	2 sections
Sodium Citrate Blood-Pack Units, (PL 146 Plastic)	Human Prescription Drug Label	1	0942-9506	SOLUTION	4 g	INTRAVENOUS	NDA	2 sections
InterSol	HUMAN PRESCRIPTION DRUG LABEL	5	0942-9601	SOLUTION	318 mg	INTRAVENOUS	NDA	13 sections
InterSol	Human Prescription Drug Label	5	0942-9602	SOLUTION	318 mg	INTRAVENOUS	NDA	13 sections
Solucion InterSol	HUMAN PRESCRIPTION DRUG LABEL	5	0942-9603	SOLUTION	318 mg	INTRAVENOUS	NDA	14 sections
ACD A	HUMAN PRESCRIPTION DRUG LABEL	3	14537-815	INJECTION, SOLUTION	2.20 g	INTRAVENOUS	ANDA	14 sections
ACD A	HUMAN PRESCRIPTION DRUG LABEL	3	14537-817	INJECTION, SOLUTION	2.20 g	INTRAVENOUS	ANDA	14 sections
Additive Formula 3	HUMAN PRESCRIPTION DRUG LABEL	6	14537-824	SOLUTION	0.59 g	INTRAVENOUS	NDA	15 sections
Additive Formula 3	HUMAN PRESCRIPTION DRUG LABEL	6	14537-826	SOLUTION	0.59 g	INTRAVENOUS	NDA	15 sections