Stem definition | Drug id | CAS RN |
---|---|---|
radiopharmaceuticals, iodine-contained | 4446 | 7553-56-2 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 1349.71 | 14.95 | 660 | 6405 | 310027 | 63171930 |
Iodine allergy | 82.92 | 14.95 | 19 | 7046 | 785 | 63481172 |
Lipoedema | 41.47 | 14.95 | 9 | 7056 | 289 | 63481668 |
Fistula discharge | 29.86 | 14.95 | 9 | 7056 | 1084 | 63480873 |
Spinal cord disorder | 28.46 | 14.95 | 9 | 7056 | 1272 | 63480685 |
Oesophagitis | 26.48 | 14.95 | 18 | 7047 | 14990 | 63466967 |
Vascular injury | 26.24 | 14.95 | 8 | 7057 | 1002 | 63480955 |
Bladder spasm | 25.51 | 14.95 | 9 | 7056 | 1779 | 63480178 |
Lymphoedema | 25.47 | 14.95 | 16 | 7049 | 11676 | 63470281 |
Myelopathy | 24.92 | 14.95 | 10 | 7055 | 2816 | 63479141 |
Drug ineffective | 24.39 | 14.95 | 50 | 7015 | 1044715 | 62437242 |
Relapsing multiple sclerosis | 22.30 | 14.95 | 5 | 7060 | 187 | 63481770 |
Urinary tract infection enterococcal | 21.86 | 14.95 | 9 | 7056 | 2704 | 63479253 |
Infected lymphocele | 21.40 | 14.95 | 5 | 7060 | 225 | 63481732 |
Endometrial cancer | 20.36 | 14.95 | 9 | 7056 | 3216 | 63478741 |
Off label use | 19.60 | 14.95 | 28 | 7037 | 674434 | 62807523 |
Vulval cancer | 19.45 | 14.95 | 6 | 7059 | 781 | 63481176 |
Premature delivery | 19.01 | 14.95 | 20 | 7045 | 30261 | 63451696 |
Venous angioma of brain | 18.94 | 14.95 | 3 | 7062 | 15 | 63481942 |
Obstructive pancreatitis | 18.38 | 14.95 | 5 | 7060 | 418 | 63481539 |
Incorrect product formulation administered | 18.18 | 14.95 | 4 | 7061 | 137 | 63481820 |
Infusion related reaction | 17.74 | 14.95 | 3 | 7062 | 245518 | 63236439 |
General physical health deterioration | 16.86 | 14.95 | 55 | 7010 | 201347 | 63280610 |
Polyhydramnios | 16.51 | 14.95 | 7 | 7058 | 2264 | 63479693 |
Urinary tract discomfort | 16.18 | 14.95 | 5 | 7060 | 655 | 63481302 |
Procedural complication | 15.90 | 14.95 | 9 | 7056 | 5430 | 63476527 |
Placental insufficiency | 15.90 | 14.95 | 6 | 7059 | 1435 | 63480522 |
Allergy to metals | 15.65 | 14.95 | 5 | 7060 | 730 | 63481227 |
Hypophagia | 15.08 | 14.95 | 18 | 7047 | 31241 | 63450716 |
Gastric mucosa erythema | 14.97 | 14.95 | 4 | 7061 | 312 | 63481645 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 261.47 | 21.23 | 122 | 2327 | 80407 | 34874075 |
Foetal exposure during pregnancy | 47.85 | 21.23 | 31 | 2418 | 38070 | 34916412 |
Epispadias | 37.87 | 21.23 | 7 | 2442 | 158 | 34954324 |
Dysmorphism | 36.18 | 21.23 | 12 | 2437 | 3144 | 34951338 |
Iodine allergy | 23.58 | 21.23 | 4 | 2445 | 54 | 34954428 |
Gastric bypass | 22.44 | 21.23 | 5 | 2444 | 292 | 34954190 |
Drug tolerance | 21.65 | 21.23 | 8 | 2441 | 2874 | 34951608 |
Dehydration | 21.37 | 21.23 | 35 | 2414 | 129934 | 34824548 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 1427.39 | 15.07 | 621 | 6039 | 298295 | 79439433 |
Iodine allergy | 59.52 | 15.07 | 13 | 6647 | 578 | 79737150 |
Lipoedema | 28.70 | 15.07 | 6 | 6654 | 216 | 79737512 |
Premature delivery | 28.44 | 15.07 | 20 | 6640 | 23447 | 79714281 |
Vascular injury | 27.68 | 15.07 | 8 | 6652 | 1113 | 79736615 |
Relapsing multiple sclerosis | 25.23 | 15.07 | 5 | 6655 | 137 | 79737591 |
Vulval cancer | 23.37 | 15.07 | 6 | 6654 | 536 | 79737192 |
Infected lymphocele | 22.54 | 15.07 | 5 | 6655 | 239 | 79737489 |
Preternatural anus | 20.50 | 15.07 | 4 | 6656 | 101 | 79737627 |
Maternal exposure during pregnancy | 20.42 | 15.07 | 39 | 6621 | 136499 | 79601229 |
Polyhydramnios | 20.35 | 15.07 | 7 | 6653 | 1713 | 79736015 |
Syndactyly | 19.41 | 15.07 | 4 | 6656 | 134 | 79737594 |
Incorrect product formulation administered | 19.21 | 15.07 | 4 | 6656 | 141 | 79737587 |
Placental insufficiency | 19.05 | 15.07 | 6 | 6654 | 1117 | 79736611 |
Hyperchromic anaemia | 18.42 | 15.07 | 4 | 6656 | 173 | 79737555 |
Diabetic foetopathy | 18.17 | 15.07 | 3 | 6657 | 28 | 79737700 |
Fistula discharge | 17.88 | 15.07 | 6 | 6654 | 1362 | 79736366 |
Contrast media allergy | 17.74 | 15.07 | 7 | 6653 | 2515 | 79735213 |
Urinary tract discomfort | 17.02 | 15.07 | 5 | 6655 | 736 | 79736992 |
Venous angioma of brain | 16.74 | 15.07 | 3 | 6657 | 47 | 79737681 |
Spinal cord disorder | 16.16 | 15.07 | 6 | 6654 | 1829 | 79735899 |
Endometrial cancer | 15.39 | 15.07 | 6 | 6654 | 2088 | 79735640 |
None
Source | Code | Description |
---|---|---|
ATC | D08AG01 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Iodine products |
ATC | D08AG03 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Iodine products |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000891 | Anti-Infective Agents, Local |
MeSH PA | D018977 | Micronutrients |
MeSH PA | D014131 | Trace Elements |
CHEBI has role | CHEBI:33284 | nutrients |
CHEBI has role | CHEBI:27027 | trace elements |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Provision of therapeutic radionuclide | indication | 74385000 | |
CD20 Positive Non-Hodgkin's Lymphoma | indication | ||
Neonatal thyrotoxicosis | off-label use | 13795004 | DOID:12573 |
Thyrotoxic crisis | off-label use | 29028009 | DOID:12837 |
Hyperthyroidism | off-label use | 34486009 | DOID:7998 |
Lymphocutaneous sporotrichosis | off-label use | 87603003 | |
Iodine deficiency | off-label use | 238121000 | |
Thyroid Surgery | off-label use | ||
Thyroid Gland Radiation Protection | off-label use | ||
Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
Hashimoto thyroiditis | contraindication | 21983002 | |
Shock | contraindication | 27942005 | |
Bronchitis | contraindication | 32398004 | DOID:6132 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Decreased respiratory function | contraindication | 80954004 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Open wound | contraindication | 125643001 | |
Seizure disorder | contraindication | 128613002 | |
Pulmonary tuberculosis | contraindication | 154283005 | DOID:2957 |
Heart block | contraindication | 233916004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypocomplementemic urticarial vasculitis | contraindication | 239945009 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Breastfeeding (mother) | contraindication | 413712001 | |
Denuded skin | contraindication | 418242004 | |
Human Anti-Mouse Antibody (HAMA) Positive | contraindication | ||
Severe Bone Marrow Depression | contraindication |
None
None
None
None
None
None
ID | Source |
---|---|
D00108 | KEGG_DRUG |
4017659 | VUID |
N0000146037 | NUI |
4017659 | VANDF |
C0021968 | UMLSCUI |
CHEBI:24859 | CHEBI |
CHEMBL1201225 | ChEMBL_ID |
DB05382 | DRUGBANK_ID |
9679TC07X4 | UNII |
807 | PUBCHEM_CID |
5933 | RXNORM |
4900 | MMSL |
d05776 | MMSL |
000852 | NDDF |
003150 | NDDF |
007599 | NDDF |
44588005 | SNOMEDCT_US |
767115003 | SNOMEDCT_US |
D007455 | MESH_DESCRIPTOR_UI |
I2I | PDB_CHEM_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Iodine | HUMAN OTC DRUG LABEL | 3 | 0363-0088 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 12 sections |
Iodine | HUMAN OTC DRUG LABEL | 3 | 0363-0088 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 12 sections |
Iodine Tincture Mild | HUMAN OTC DRUG LABEL | 3 | 0395-1213 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 13 sections |
Iodine Tincture Mild | HUMAN OTC DRUG LABEL | 3 | 0395-1213 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 13 sections |
Humco Strong Iodine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0395-2775 | LIQUID | 50 mg | ORAL | unapproved drug other | 12 sections |
Humco Strong Iodine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0395-2775 | LIQUID | 50 mg | ORAL | unapproved drug other | 12 sections |
Iodine Tincture Mild | HUMAN OTC DRUG LABEL | 3 | 0395-9118 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 13 sections |
VitafolOne | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-0070 | CAPSULE, GELATIN COATED | 0.15 mg | ORAL | unapproved drug other | 14 sections |
Vitafol Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0092 | CAPSULE, LIQUID FILLED | 200 ug | ORAL | UNAPPROVED DRUG OTHER | 13 sections |
Vitafol Nano | HUMAN PRESCRIPTION DRUG LABEL | 7 | 0642-0094 | TABLET, COATED | 150 ug | ORAL | UNAPPROVED DRUG OTHER | 14 sections |
Vitafol Nano | HUMAN PRESCRIPTION DRUG LABEL | 7 | 0642-0094 | TABLET, COATED | 150 ug | ORAL | UNAPPROVED DRUG OTHER | 14 sections |
Reaphirm Plant Source DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-3010 | CAPSULE, GELATIN COATED | 0.15 mg | ORAL | unapproved drug other | 7 sections |
O-Cal Prenatal Vitamin | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0813-0202 | TABLET | 150 ug | ORAL | UNAPPROVED DRUG OTHER | 6 sections |
Iodine | HUMAN OTC DRUG LABEL | 3 | 0869-0088 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 12 sections |
Iodine | HUMAN OTC DRUG LABEL | 3 | 0869-0088 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 12 sections |
Iodine | HUMAN OTC DRUG LABEL | 3 | 0869-0088 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 12 sections |
LUGOLS SOLUTION | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10481-0111 | LIQUID | 0.40 g | TOPICAL | unapproved drug other | 5 sections |
Iodine | HUMAN OTC DRUG LABEL | 3 | 11344-088 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 12 sections |
IODIUM | HUMAN OTC DRUG LABEL | 1 | 15631-0236 | PELLET | 3 [hp_X] | ORAL | unapproved homeopathic | 13 sections |
IODINE | HUMAN OTC DRUG LABEL | 2 | 16638-166 | SOLUTION | 0.50 g | TOPICAL | OTC monograph not final | 9 sections |
De La Cruz Tincture of Iodine | HUMAN OTC DRUG LABEL | 3 | 24286-1528 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 13 sections |
De La Cruz Tincture of Iodine | HUMAN OTC DRUG LABEL | 3 | 24286-1528 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 13 sections |
GNP Idoinde Tincture 2% Mild | HUMAN OTC DRUG LABEL | 3 | 24385-213 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 14 sections |
GNP Idoinde Tincture 2% Mild | HUMAN OTC DRUG LABEL | 3 | 24385-213 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 14 sections |
Iodine Tincture | HUMAN OTC DRUG LABEL | 2 | 30142-088 | SOLUTION/ DROPS | 20 mg | TOPICAL | OTC monograph not final | 13 sections |
Iodine Tincture | HUMAN OTC DRUG LABEL | 2 | 30142-088 | SOLUTION/ DROPS | 20 mg | TOPICAL | OTC monograph not final | 13 sections |
LEADER Mild Iodine | HUMAN OTC DRUG LABEL | 3 | 37205-022 | TINCTURE | 2 mg | TOPICAL | OTC monograph not final | 11 sections |
Iodine | HUMAN OTC DRUG LABEL | 3 | 41163-088 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 12 sections |
Iodine | HUMAN OTC DRUG LABEL | 3 | 41163-088 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 12 sections |
Iodine | HUMAN OTC DRUG LABEL | 3 | 41163-088 | LIQUID | 20 mg | TOPICAL | OTC monograph not final | 12 sections |