iodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4446 7553-56-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iodine
A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
  • Molecular weight: 253.81
  • Formula: I2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1396.97 15.86 640 5257 250370 50348857
Iodine allergy 58.11 15.86 14 5883 687 50598540
Lipoedema 41.85 15.86 9 5888 264 50598963
Fistula discharge 30.80 15.86 9 5888 931 50598296
Spinal cord disorder 28.58 15.86 9 5888 1198 50598029
Oesophagitis 27.61 15.86 18 5879 13365 50585862
Vascular injury 27.10 15.86 8 5889 857 50598370
Bladder spasm 27.08 15.86 9 5888 1421 50597806
Myelopathy 25.42 15.86 10 5887 2551 50596676
General physical health deterioration 22.95 15.86 51 5846 142383 50456844
Urinary tract infection enterococcal 22.41 15.86 9 5888 2425 50596802
Infected lymphocele 21.65 15.86 5 5892 204 50599023
Endometrial cancer 20.93 15.86 9 5888 2874 50596353
Lymphoedema 20.63 15.86 13 5884 9109 50590118
Vulval cancer 20.02 15.86 6 5891 677 50598550
Drug ineffective 17.62 15.86 44 5853 819289 49779938
Polyhydramnios 16.97 15.86 7 5890 2018 50597209
Procedural complication 16.53 15.86 9 5888 4814 50594413
Placental insufficiency 16.32 15.86 6 5891 1275 50597952
Off label use 16.10 15.86 19 5878 474407 50124820

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 263.81 21.05 120 2148 68286 29503973
Epispadias 37.23 21.05 7 2261 158 29572101
Dysmorphism 35.83 21.05 12 2256 2959 29569300
Foetal exposure during pregnancy 32.07 21.05 24 2244 33843 29538416
Drug tolerance 23.22 21.05 8 2260 2145 29570114
Iodine allergy 23.21 21.05 4 2264 54 29572205
Gastric bypass 22.53 21.05 5 2263 261 29571998
Dehydration 22.27 21.05 35 2233 114713 29457546
Hyperleukocytosis 21.29 21.05 7 2261 1628 29570631

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1476.35 16.47 607 5190 237208 64255727
Iodine allergy 43.56 16.47 10 5787 518 64492417
Lipoedema 28.94 16.47 6 5791 192 64492743
Vascular injury 27.63 16.47 8 5789 1041 64491894
Vulval cancer 24.26 16.47 6 5791 428 64492507
Maternal exposure during pregnancy 22.73 16.47 35 5762 95849 64397086
Infected lymphocele 22.55 16.47 5 5792 221 64492714
Polyhydramnios 20.85 16.47 7 5790 1480 64491455
Preternatural anus 20.21 16.47 4 5793 101 64492834
Premature delivery 19.61 16.47 15 5782 18574 64474361
Fistula discharge 19.30 16.47 6 5791 994 64491941
Placental insufficiency 19.18 16.47 6 5791 1014 64491921
Hyperchromic anaemia 18.24 16.47 4 5793 168 64492767
Diabetic foetopathy 17.95 16.47 3 5794 28 64492907

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AG01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
ATC D08AG03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D018977 Micronutrients
MeSH PA D014131 Trace Elements
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Provision of therapeutic radionuclide indication 74385000
CD20 Positive Non-Hodgkin's Lymphoma indication
Neonatal thyrotoxicosis off-label use 13795004 DOID:12573
Thyrotoxic crisis off-label use 29028009 DOID:12837
Hyperthyroidism off-label use 34486009 DOID:7998
Lymphocutaneous sporotrichosis off-label use 87603003
Iodine deficiency off-label use 238121000
Thyroid Surgery off-label use
Thyroid Gland Radiation Protection off-label use
Bacterial septicemia contraindication 10001005 DOID:0040085
Hashimoto thyroiditis contraindication 21983002
Shock contraindication 27942005
Bronchitis contraindication 32398004 DOID:6132
Hypothyroidism contraindication 40930008 DOID:1459
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Pulmonary tuberculosis contraindication 154283005 DOID:2957
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004
Human Anti-Mouse Antibody (HAMA) Positive contraindication
Severe Bone Marrow Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00108 KEGG_DRUG
4017659 VUID
N0000146037 NUI
4017659 VANDF
C0021968 UMLSCUI
CHEBI:24859 CHEBI
CHEMBL1201225 ChEMBL_ID
DB05382 DRUGBANK_ID
9679TC07X4 UNII
807 PUBCHEM_CID
5933 RXNORM
4900 MMSL
d05776 MMSL
000852 NDDF
003150 NDDF
007599 NDDF
44588005 SNOMEDCT_US
767115003 SNOMEDCT_US
D007455 MESH_DESCRIPTOR_UI
I2I PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Iodine HUMAN OTC DRUG LABEL 3 0363-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-1213 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-1213 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
Humco Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 0395-2775 LIQUID 50 mg ORAL unapproved drug other 12 sections
Humco Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 0395-2775 LIQUID 50 mg ORAL unapproved drug other 12 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-9118 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 0.15 mg ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 200 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 150 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 0.15 mg ORAL unapproved drug other 7 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 150 ug ORAL UNAPPROVED DRUG OTHER 6 sections
Iodine HUMAN OTC DRUG LABEL 3 0869-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
LUGOLS SOLUTION HUMAN PRESCRIPTION DRUG LABEL 1 10481-0111 LIQUID 0.40 g TOPICAL unapproved drug other 5 sections
Iodine HUMAN OTC DRUG LABEL 3 11344-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
IODIUM HUMAN OTC DRUG LABEL 1 15631-0236 PELLET 3 [hp_X] ORAL unapproved homeopathic 13 sections
IODINE HUMAN OTC DRUG LABEL 2 16638-166 SOLUTION 0.50 g TOPICAL OTC monograph not final 9 sections
De La Cruz Tincture of Iodine HUMAN OTC DRUG LABEL 3 24286-1528 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
De La Cruz Tincture of Iodine HUMAN OTC DRUG LABEL 3 24286-1528 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
GNP Idoinde Tincture 2% Mild HUMAN OTC DRUG LABEL 3 24385-213 LIQUID 20 mg TOPICAL OTC monograph not final 14 sections
GNP Idoinde Tincture 2% Mild HUMAN OTC DRUG LABEL 3 24385-213 LIQUID 20 mg TOPICAL OTC monograph not final 14 sections
Iodine Tincture HUMAN OTC DRUG LABEL 2 30142-088 SOLUTION/ DROPS 20 mg TOPICAL OTC monograph not final 13 sections
LEADER Mild Iodine HUMAN OTC DRUG LABEL 3 37205-022 TINCTURE 2 mg TOPICAL OTC monograph not final 11 sections
Iodine HUMAN OTC DRUG LABEL 3 41163-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Strong Iodine Solution HUMAN PRESCRIPTION DRUG LABEL 2 48433-230 SOLUTION/ DROPS 700 mg ORAL unapproved drug other 11 sections
Sunmark Iodine HUMAN OTC DRUG LABEL 3 49348-133 TINCTURE 20 mg TOPICAL OTC monograph not final 7 sections
Sunmark Iodine HUMAN OTC DRUG LABEL 3 49348-133 TINCTURE 20 mg TOPICAL OTC monograph not final 7 sections
Iodine HUMAN OTC DRUG LABEL 3 50804-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
DDM Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 53943-213 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
DDM Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 53943-213 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
Lugols Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 59365-6064 SOLUTION 0.05 g TOPICAL UNAPPROVED DRUG OTHER 10 sections