iodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
radiopharmaceuticals, iodine-contained	4446	7553-56-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: iodine	A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically. Molecular weight: 253.81 Formula: I2 CLOGP: LIPINSKI: None HAC: 0 HDO: 0 TPSA: ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

iodine

A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.

Molecular weight: 253.81
Formula: I2
CLOGP:
LIPINSKI: None
HAC: 0
HDO: 0
TPSA:
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	1349.71	14.95	660	6405	310027	63171930
Iodine allergy	82.92	14.95	19	7046	785	63481172
Lipoedema	41.47	14.95	9	7056	289	63481668
Fistula discharge	29.86	14.95	9	7056	1084	63480873
Spinal cord disorder	28.46	14.95	9	7056	1272	63480685
Oesophagitis	26.48	14.95	18	7047	14990	63466967
Vascular injury	26.24	14.95	8	7057	1002	63480955
Bladder spasm	25.51	14.95	9	7056	1779	63480178
Lymphoedema	25.47	14.95	16	7049	11676	63470281
Myelopathy	24.92	14.95	10	7055	2816	63479141
Drug ineffective	24.39	14.95	50	7015	1044715	62437242
Relapsing multiple sclerosis	22.30	14.95	5	7060	187	63481770
Urinary tract infection enterococcal	21.86	14.95	9	7056	2704	63479253
Infected lymphocele	21.40	14.95	5	7060	225	63481732
Endometrial cancer	20.36	14.95	9	7056	3216	63478741
Off label use	19.60	14.95	28	7037	674434	62807523
Vulval cancer	19.45	14.95	6	7059	781	63481176
Premature delivery	19.01	14.95	20	7045	30261	63451696
Venous angioma of brain	18.94	14.95	3	7062	15	63481942
Obstructive pancreatitis	18.38	14.95	5	7060	418	63481539
Incorrect product formulation administered	18.18	14.95	4	7061	137	63481820
Infusion related reaction	17.74	14.95	3	7062	245518	63236439
General physical health deterioration	16.86	14.95	55	7010	201347	63280610
Polyhydramnios	16.51	14.95	7	7058	2264	63479693
Urinary tract discomfort	16.18	14.95	5	7060	655	63481302
Procedural complication	15.90	14.95	9	7056	5430	63476527
Placental insufficiency	15.90	14.95	6	7059	1435	63480522
Allergy to metals	15.65	14.95	5	7060	730	63481227
Hypophagia	15.08	14.95	18	7047	31241	63450716
Gastric mucosa erythema	14.97	14.95	4	7061	312	63481645

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	261.47	21.23	122	2327	80407	34874075
Foetal exposure during pregnancy	47.85	21.23	31	2418	38070	34916412
Epispadias	37.87	21.23	7	2442	158	34954324
Dysmorphism	36.18	21.23	12	2437	3144	34951338
Iodine allergy	23.58	21.23	4	2445	54	34954428
Gastric bypass	22.44	21.23	5	2444	292	34954190
Drug tolerance	21.65	21.23	8	2441	2874	34951608
Dehydration	21.37	21.23	35	2414	129934	34824548

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	1427.39	15.07	621	6039	298295	79439433
Iodine allergy	59.52	15.07	13	6647	578	79737150
Lipoedema	28.70	15.07	6	6654	216	79737512
Premature delivery	28.44	15.07	20	6640	23447	79714281
Vascular injury	27.68	15.07	8	6652	1113	79736615
Relapsing multiple sclerosis	25.23	15.07	5	6655	137	79737591
Vulval cancer	23.37	15.07	6	6654	536	79737192
Infected lymphocele	22.54	15.07	5	6655	239	79737489
Preternatural anus	20.50	15.07	4	6656	101	79737627
Maternal exposure during pregnancy	20.42	15.07	39	6621	136499	79601229
Polyhydramnios	20.35	15.07	7	6653	1713	79736015
Syndactyly	19.41	15.07	4	6656	134	79737594
Incorrect product formulation administered	19.21	15.07	4	6656	141	79737587
Placental insufficiency	19.05	15.07	6	6654	1117	79736611
Hyperchromic anaemia	18.42	15.07	4	6656	173	79737555
Diabetic foetopathy	18.17	15.07	3	6657	28	79737700
Fistula discharge	17.88	15.07	6	6654	1362	79736366
Contrast media allergy	17.74	15.07	7	6653	2515	79735213
Urinary tract discomfort	17.02	15.07	5	6655	736	79736992
Venous angioma of brain	16.74	15.07	3	6657	47	79737681
Spinal cord disorder	16.16	15.07	6	6654	1829	79735899
Endometrial cancer	15.39	15.07	6	6654	2088	79735640

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AG01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Iodine products
ATC	D08AG03	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Iodine products
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D018977	Micronutrients
MeSH PA	D014131	Trace Elements
CHEBI has role	CHEBI:33284	nutrients
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Provision of therapeutic radionuclide	indication	74385000
CD20 Positive Non-Hodgkin's Lymphoma	indication
Neonatal thyrotoxicosis	off-label use	13795004	DOID:12573
Thyrotoxic crisis	off-label use	29028009	DOID:12837
Hyperthyroidism	off-label use	34486009	DOID:7998
Lymphocutaneous sporotrichosis	off-label use	87603003
Iodine deficiency	off-label use	238121000
Thyroid Surgery	off-label use
Thyroid Gland Radiation Protection	off-label use
Bacterial septicemia	contraindication	10001005	DOID:0040085
Hashimoto thyroiditis	contraindication	21983002
Shock	contraindication	27942005
Bronchitis	contraindication	32398004	DOID:6132
Hypothyroidism	contraindication	40930008	DOID:1459
Decreased respiratory function	contraindication	80954004
Kidney disease	contraindication	90708001	DOID:557
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Pulmonary tuberculosis	contraindication	154283005	DOID:2957
Heart block	contraindication	233916004
Disease of liver	contraindication	235856003	DOID:409
Hypocomplementemic urticarial vasculitis	contraindication	239945009
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Breastfeeding (mother)	contraindication	413712001
Denuded skin	contraindication	418242004
Human Anti-Mouse Antibody (HAMA) Positive	contraindication
Severe Bone Marrow Depression	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D00108	KEGG_DRUG
4017659	VUID
N0000146037	NUI
4017659	VANDF
C0021968	UMLSCUI
CHEBI:24859	CHEBI
CHEMBL1201225	ChEMBL_ID
DB05382	DRUGBANK_ID
9679TC07X4	UNII
807	PUBCHEM_CID
5933	RXNORM
4900	MMSL
d05776	MMSL
000852	NDDF
003150	NDDF
007599	NDDF
44588005	SNOMEDCT_US
767115003	SNOMEDCT_US
D007455	MESH_DESCRIPTOR_UI
I2I	PDB_CHEM_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Iodine	HUMAN OTC DRUG LABEL	3	0363-0088	LIQUID	20 mg	TOPICAL	OTC monograph not final	12 sections
Iodine	HUMAN OTC DRUG LABEL	3	0363-0088	LIQUID	20 mg	TOPICAL	OTC monograph not final	12 sections
Iodine Tincture Mild	HUMAN OTC DRUG LABEL	3	0395-1213	LIQUID	20 mg	TOPICAL	OTC monograph not final	13 sections
Iodine Tincture Mild	HUMAN OTC DRUG LABEL	3	0395-1213	LIQUID	20 mg	TOPICAL	OTC monograph not final	13 sections
Humco Strong Iodine	HUMAN PRESCRIPTION DRUG LABEL	2	0395-2775	LIQUID	50 mg	ORAL	unapproved drug other	12 sections
Humco Strong Iodine	HUMAN PRESCRIPTION DRUG LABEL	2	0395-2775	LIQUID	50 mg	ORAL	unapproved drug other	12 sections
Iodine Tincture Mild	HUMAN OTC DRUG LABEL	3	0395-9118	LIQUID	20 mg	TOPICAL	OTC monograph not final	13 sections
VitafolOne	HUMAN PRESCRIPTION DRUG LABEL	16	0642-0070	CAPSULE, GELATIN COATED	0.15 mg	ORAL	unapproved drug other	14 sections
Vitafol Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0092	CAPSULE, LIQUID FILLED	200 ug	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol Nano	HUMAN PRESCRIPTION DRUG LABEL	7	0642-0094	TABLET, COATED	150 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
Vitafol Nano	HUMAN PRESCRIPTION DRUG LABEL	7	0642-0094	TABLET, COATED	150 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
Reaphirm Plant Source DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0642-3010	CAPSULE, GELATIN COATED	0.15 mg	ORAL	unapproved drug other	7 sections
O-Cal Prenatal Vitamin	HUMAN PRESCRIPTION DRUG LABEL	16	0813-0202	TABLET	150 ug	ORAL	UNAPPROVED DRUG OTHER	6 sections
Iodine	HUMAN OTC DRUG LABEL	3	0869-0088	LIQUID	20 mg	TOPICAL	OTC monograph not final	12 sections
Iodine	HUMAN OTC DRUG LABEL	3	0869-0088	LIQUID	20 mg	TOPICAL	OTC monograph not final	12 sections
Iodine	HUMAN OTC DRUG LABEL	3	0869-0088	LIQUID	20 mg	TOPICAL	OTC monograph not final	12 sections
LUGOLS SOLUTION	HUMAN PRESCRIPTION DRUG LABEL	1	10481-0111	LIQUID	0.40 g	TOPICAL	unapproved drug other	5 sections
Iodine	HUMAN OTC DRUG LABEL	3	11344-088	LIQUID	20 mg	TOPICAL	OTC monograph not final	12 sections
IODIUM	HUMAN OTC DRUG LABEL	1	15631-0236	PELLET	3 [hp_X]	ORAL	unapproved homeopathic	13 sections
IODINE	HUMAN OTC DRUG LABEL	2	16638-166	SOLUTION	0.50 g	TOPICAL	OTC monograph not final	9 sections
De La Cruz Tincture of Iodine	HUMAN OTC DRUG LABEL	3	24286-1528	LIQUID	20 mg	TOPICAL	OTC monograph not final	13 sections
De La Cruz Tincture of Iodine	HUMAN OTC DRUG LABEL	3	24286-1528	LIQUID	20 mg	TOPICAL	OTC monograph not final	13 sections
GNP Idoinde Tincture 2% Mild	HUMAN OTC DRUG LABEL	3	24385-213	LIQUID	20 mg	TOPICAL	OTC monograph not final	14 sections
GNP Idoinde Tincture 2% Mild	HUMAN OTC DRUG LABEL	3	24385-213	LIQUID	20 mg	TOPICAL	OTC monograph not final	14 sections
Iodine Tincture	HUMAN OTC DRUG LABEL	2	30142-088	SOLUTION/ DROPS	20 mg	TOPICAL	OTC monograph not final	13 sections
Iodine Tincture	HUMAN OTC DRUG LABEL	2	30142-088	SOLUTION/ DROPS	20 mg	TOPICAL	OTC monograph not final	13 sections
LEADER Mild Iodine	HUMAN OTC DRUG LABEL	3	37205-022	TINCTURE	2 mg	TOPICAL	OTC monograph not final	11 sections
Iodine	HUMAN OTC DRUG LABEL	3	41163-088	LIQUID	20 mg	TOPICAL	OTC monograph not final	12 sections
Iodine	HUMAN OTC DRUG LABEL	3	41163-088	LIQUID	20 mg	TOPICAL	OTC monograph not final	12 sections
Iodine	HUMAN OTC DRUG LABEL	3	41163-088	LIQUID	20 mg	TOPICAL	OTC monograph not final	12 sections