iodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4446 7553-56-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iodine
A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
  • Molecular weight: 253.81
  • Formula: I2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1384.18 16.32 650 5751 274555 56011111
Iodine allergy 72.61 16.32 17 6384 756 56284910
Lipoedema 41.71 16.32 9 6392 275 56285391
Fistula discharge 30.54 16.32 9 6392 982 56284684
Spinal cord disorder 28.42 16.32 9 6392 1250 56284416
Oesophagitis 27.20 16.32 18 6383 14039 56271627
Bladder spasm 26.53 16.32 9 6392 1550 56284116
Vascular injury 26.34 16.32 8 6393 968 56284698
Myelopathy 25.34 16.32 10 6391 2638 56283028
Lymphoedema 24.13 16.32 15 6386 10515 56275151
Drug ineffective 22.73 16.32 44 6357 918945 55366721
Urinary tract infection enterococcal 22.01 16.32 9 6392 2600 56283066
General physical health deterioration 21.94 16.32 55 6346 169955 56115711
Infected lymphocele 21.52 16.32 5 6396 215 56285451
Endometrial cancer 20.72 16.32 9 6392 3021 56282645
Vulval cancer 19.65 16.32 6 6395 739 56284927
Rheumatoid arthritis 18.89 16.32 10 6391 382594 55903072
Incorrect product formulation administered 18.58 16.32 4 6397 121 56285545
Off label use 17.11 16.32 23 6378 556157 55729509
Polyhydramnios 16.84 16.32 7 6394 2108 56283558
Procedural complication 16.38 16.32 9 6392 5022 56280644

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 267.90 21.52 122 2212 72477 31622533
Foetal exposure during pregnancy 39.85 21.52 29 2305 40847 31654163
Epispadias 37.52 21.52 7 2327 158 31694852
Dysmorphism 35.91 21.52 12 2322 3060 31691950
Iodine allergy 23.38 21.52 4 2330 54 31694956
Gastric bypass 22.72 21.52 5 2329 262 31694748
Dehydration 22.36 21.52 35 2299 119076 31575934
Drug tolerance 22.29 21.52 8 2326 2519 31692491

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1480.18 16.30 616 5418 261843 70660567
Iodine allergy 48.84 16.30 11 6023 553 70921857
Lipoedema 29.04 16.30 6 6028 200 70922210
Vascular injury 27.77 16.30 8 6026 1081 70921329
Vulval cancer 23.85 16.30 6 6028 485 70921925
Premature delivery 22.89 16.30 17 6017 21287 70901123
Infected lymphocele 22.61 16.30 5 6029 231 70922179
Maternal exposure during pregnancy 21.98 16.30 37 5997 115308 70807102
Polyhydramnios 21.14 16.30 7 6027 1499 70920911
Preternatural anus 20.43 16.30 4 6030 101 70922309
Incorrect product formulation administered 19.70 16.30 4 6030 122 70922288
Syndactyly 19.37 16.30 4 6030 133 70922277
Placental insufficiency 19.22 16.30 6 6028 1065 70921345
Fistula discharge 18.87 16.30 6 6028 1130 70921280
Hyperchromic anaemia 18.44 16.30 4 6030 169 70922241
Diabetic foetopathy 18.11 16.30 3 6031 28 70922382
Spinal cord disorder 16.39 16.30 6 6028 1725 70920685

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AG01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
ATC D08AG03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D018977 Micronutrients
MeSH PA D014131 Trace Elements
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Provision of therapeutic radionuclide indication 74385000
CD20 Positive Non-Hodgkin's Lymphoma indication
Neonatal thyrotoxicosis off-label use 13795004 DOID:12573
Thyrotoxic crisis off-label use 29028009 DOID:12837
Hyperthyroidism off-label use 34486009 DOID:7998
Lymphocutaneous sporotrichosis off-label use 87603003
Iodine deficiency off-label use 238121000
Thyroid Surgery off-label use
Thyroid Gland Radiation Protection off-label use
Bacterial septicemia contraindication 10001005 DOID:0040085
Hashimoto thyroiditis contraindication 21983002
Shock contraindication 27942005
Bronchitis contraindication 32398004 DOID:6132
Hypothyroidism contraindication 40930008 DOID:1459
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Pulmonary tuberculosis contraindication 154283005 DOID:2957
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004
Human Anti-Mouse Antibody (HAMA) Positive contraindication
Severe Bone Marrow Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00108 KEGG_DRUG
4017659 VUID
N0000146037 NUI
4017659 VANDF
C0021968 UMLSCUI
CHEBI:24859 CHEBI
CHEMBL1201225 ChEMBL_ID
DB05382 DRUGBANK_ID
9679TC07X4 UNII
807 PUBCHEM_CID
5933 RXNORM
4900 MMSL
d05776 MMSL
000852 NDDF
003150 NDDF
007599 NDDF
44588005 SNOMEDCT_US
767115003 SNOMEDCT_US
D007455 MESH_DESCRIPTOR_UI
I2I PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Iodine HUMAN OTC DRUG LABEL 3 0363-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-1213 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-1213 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
Humco Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 0395-2775 LIQUID 50 mg ORAL unapproved drug other 12 sections
Humco Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 0395-2775 LIQUID 50 mg ORAL unapproved drug other 12 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-9118 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 0.15 mg ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 200 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 150 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 0.15 mg ORAL unapproved drug other 7 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 150 ug ORAL UNAPPROVED DRUG OTHER 6 sections
Iodine HUMAN OTC DRUG LABEL 3 0869-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 0869-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
LUGOLS SOLUTION HUMAN PRESCRIPTION DRUG LABEL 1 10481-0111 LIQUID 0.40 g TOPICAL unapproved drug other 5 sections
Iodine HUMAN OTC DRUG LABEL 3 11344-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
IODIUM HUMAN OTC DRUG LABEL 1 15631-0236 PELLET 3 [hp_X] ORAL unapproved homeopathic 13 sections
IODINE HUMAN OTC DRUG LABEL 2 16638-166 SOLUTION 0.50 g TOPICAL OTC monograph not final 9 sections
De La Cruz Tincture of Iodine HUMAN OTC DRUG LABEL 3 24286-1528 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
De La Cruz Tincture of Iodine HUMAN OTC DRUG LABEL 3 24286-1528 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
GNP Idoinde Tincture 2% Mild HUMAN OTC DRUG LABEL 3 24385-213 LIQUID 20 mg TOPICAL OTC monograph not final 14 sections
GNP Idoinde Tincture 2% Mild HUMAN OTC DRUG LABEL 3 24385-213 LIQUID 20 mg TOPICAL OTC monograph not final 14 sections
Iodine Tincture HUMAN OTC DRUG LABEL 2 30142-088 SOLUTION/ DROPS 20 mg TOPICAL OTC monograph not final 13 sections
LEADER Mild Iodine HUMAN OTC DRUG LABEL 3 37205-022 TINCTURE 2 mg TOPICAL OTC monograph not final 11 sections
Iodine HUMAN OTC DRUG LABEL 3 41163-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 41163-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Strong Iodine Solution HUMAN PRESCRIPTION DRUG LABEL 2 48433-230 SOLUTION/ DROPS 700 mg ORAL unapproved drug other 11 sections
Sunmark Iodine HUMAN OTC DRUG LABEL 3 49348-133 TINCTURE 20 mg TOPICAL OTC monograph not final 7 sections
Sunmark Iodine HUMAN OTC DRUG LABEL 3 49348-133 TINCTURE 20 mg TOPICAL OTC monograph not final 7 sections
Iodine HUMAN OTC DRUG LABEL 3 50804-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 50804-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections