All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sodium benzoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4373	532-32-1

Description:

Molecule	Description
Synonyms: sodium benzoate	The sodium salt of BENZOIC ACID. It is used as an antifungal preservative in pharmaceutical preparations and foods. It may also be used as a test for liver function. Molecular weight: 144.11 Formula: C7H5NaO2 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 40.13 ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Dec. 23, 1987	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Creatinine renal clearance decreased	174.20	124.24	39	774	18860	90608774
Sedation complication	167.31	124.24	37	776	16907	90610727
Orthostatic hypotension	157.61	124.24	42	771	41785	90585849
Blood calcium decreased	156.04	124.24	39	774	30143	90597491
Sedation	128.92	124.24	37	776	48134	90579500
Cognitive disorder	128.10	124.24	40	773	69367	90558267

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Creatinine renal clearance decreased	184.97	98.09	42	941	21773	110566543
Sedation complication	177.93	98.09	40	943	19815	110568501
Blood calcium decreased	164.24	98.09	42	941	35803	110552513
Orthostatic hypotension	151.74	98.09	45	938	66204	110522112
Cognitive disorder	135.30	98.09	44	939	87467	110500849
Sedation	123.94	98.09	39	944	69644	110518672
Depressed level of consciousness	116.93	98.09	42	941	112236	110476080
Balance disorder	115.40	98.09	42	941	116518	110471798
Hyperammonaemia	108.49	98.09	25	958	13707	110574609

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A16AX11	ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Various alimentary tract and metabolism products
ATC	A16AX30	ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Various alimentary tract and metabolism products
ATC	V04CG30	VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for gastric secretion
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents
MeSH PA	D005503	Food Additives
MeSH PA	D005520	Food Preservatives
CHEBI has role	CHEBI:35476	antipsychotic agent
CHEBI has role	CHEBI:64996	EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor
CHEBI has role	CHEBI:65001	EC 3.1.1.3 (triacylglycerol lipase) inhibitor
CHEBI has role	CHEBI:65256	antimicrobial food preservative
CHEBI has role	CHEBI:76924	plant metabolite
CHEBI has role	CHEBI:76967	human xenobiotic metabolite
CHEBI has role	CHEBI:84735	algal metabolite
CHEBI has role	CHEBI:88188	drug allergen

Related Drugs by ATC class:

A16AX Various alimentary tract and metabolism products 23 drugs

anethole trithionedoxecitinedoxribtimineeliglustatfosdenopteringivosiranglycerol phenylbutyratelonafarniblumasiranmigalastatmiglustatnedosiran show all 23 →

V04CG Tests for gastric secretion 5 drugs

betazolecaffeinehistaminemethylthioninium chloridepentagastrin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hyperammonemia	indication	9360008
Apnea in the newborn	indication	13094009
Fatigue	off-label use	84229001
Drowsy	off-label use	271782001
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Peptic ulcer	contraindication	13200003	DOID:750
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypokalemia	contraindication	43339004
Body fluid retention	contraindication	43498006
Conduction disorder of the heart	contraindication	44808001
Chronic heart failure	contraindication	48447003
Acute nephropathy	contraindication	58574008
Metabolic acidosis	contraindication	59455009
Hepatic failure	contraindication	59927004
Agoraphobia	contraindication	70691001	DOID:593
Hyperglycemia	contraindication	80394007	DOID:4195
Kidney disease	contraindication	90708001	DOID:557
Seizure disorder	contraindication	128613002
Obsessive-compulsive disorder	contraindication	191736004	DOID:10933
Insomnia	contraindication	193462001
Impaired renal function disorder	contraindication	197663003
Disease of liver	contraindication	235856003	DOID:409
Edema	contraindication	267038008
Panic disorder	contraindication	371631005	DOID:594
Myocardial ischemia	contraindication	414795007	DOID:3393
Myocardial infarction in recovery phase	contraindication	418044006
CNS Toxicity	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Ki	4.52		CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	4.13		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	4.61		CHEMBL

External reference:

ID	Source
D02277	KEGG_DRUG
4017797	VUID
N0000146158	NUI
4017797	VANDF
C0142805	UMLSCUI
CHEBI:113455	CHEBI
CHEMBL1356	ChEMBL_ID
OJ245FE5EU	UNII
517055	PUBCHEM_CID
56455	RXNORM
5206	MMSL
5472	MMSL
d03096	MMSL
001243	NDDF
003194	NDDF
125706008	SNOMEDCT_US
398718007	SNOMEDCT_US
D020160	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ammonul	HUMAN PRESCRIPTION DRUG LABEL	2	62592-720	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	NDA	28 sections
SODIUM PHENYLACETATE AND SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	68382-396	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	24 sections
Sodium Phenylacetate and sodium benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	68475-001	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	24 sections
Sodium phenylacetate and Sodium benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	68475-513	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	24 sections
SODIUM PHENYLACETATE AND SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	70511-101	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
Sodium Phenylacetate and Sodium Benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	70511-102	INJECTION	100 mg	INTRAVENOUS	NDA	29 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	70556-100	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
Sodium phenylacetate and Sodium benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	70710-1926	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	24 sections
Sodium Phenylacetate and Sodium Benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	72266-236	INJECTION	100 mg	INTRAVENOUS	NDA	29 sections
seo jeong ho hwang chill mist	HUMAN OTC DRUG LABEL	1	76675-0006	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections
seo jeong ho hwang chill deodorant	HUMAN OTC DRUG LABEL	1	76675-0008	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections
s panax mist for refill	HUMAN OTC DRUG LABEL	1	76675-0011	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections
s panax mist	HUMAN OTC DRUG LABEL	1	76675-0013	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	81665-203	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	81665-204	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
s panax all in one mist	HUMAN OTC DRUG LABEL	1	81885-0002	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections
GKV Anti Dandruff Smooth	HUMAN OTC DRUG LABEL	7	84558-001	SHAMPOO	0.40 g	TOPICAL	OTC Monograph Drug	12 sections