sodium benzoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4373	532-32-1

Description:

Molecule	Description
Synonyms: sodium benzoate	The sodium salt of BENZOIC ACID. It is used as an antifungal preservative in pharmaceutical preparations and foods. It may also be used as a test for liver function. Molecular weight: 144.11 Formula: C7H5NaO2 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 40.13 ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium benzoate

The sodium salt of BENZOIC ACID. It is used as an antifungal preservative in pharmaceutical preparations and foods. It may also be used as a test for liver function.

Molecular weight: 144.11
Formula: C7H5NaO2
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 40.13
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 23, 1987	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Creatinine renal clearance decreased	115.89	75.63	27	518	16281	63472196
Orthostatic hypotension	108.27	75.63	30	515	36130	63452347
Sedation complication	104.08	75.63	24	521	13798	63474679
Blood calcium decreased	102.91	75.63	27	518	26424	63462053
Cognitive disorder	82.99	75.63	27	518	55788	63432689
Sedation	79.51	75.63	24	521	38785	63449692

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Creatinine renal clearance decreased	127.24	61.93	30	655	18972	79724731
Sedation complication	116.80	61.93	27	658	15642	79728061
Blood calcium decreased	111.88	61.93	30	655	31789	79711914
Orthostatic hypotension	107.71	61.93	33	652	56131	79687572
Cognitive disorder	92.54	61.93	31	654	69895	79673808
Hyperammonaemia	87.32	61.93	20	665	11073	79732630
Sedation	80.65	61.93	26	659	51869	79691834
Depressed level of consciousness	75.47	61.93	29	656	96623	79647080
Balance disorder	74.83	61.93	29	656	98828	79644875
Mobility decreased	62.23	61.93	27	658	122148	79621555

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A16AX11	ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Various alimentary tract and metabolism products
ATC	A16AX30	ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Various alimentary tract and metabolism products
ATC	V04CG30	VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for gastric secretion
CHEBI has role	CHEBI:64996	omega(6) lipoxygenase inhibitor
CHEBI has role	CHEBI:65001	tributyrin esterase inhibitor
CHEBI has role	CHEBI:65256	antimicrobial food preservatives
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:76967	human xenobiotic metabolites
CHEBI has role	CHEBI:84735	algal metabolites
CHEBI has role	CHEBI:88188	allergenic drug

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Hyperammonemia	indication	9360008
Apnea in the newborn	indication	13094009
Fatigue	off-label use	84229001
Drowsy	off-label use	271782001
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Peptic ulcer	contraindication	13200003	DOID:750
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypokalemia	contraindication	43339004
Body fluid retention	contraindication	43498006
Conduction disorder of the heart	contraindication	44808001

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN	Ki	4.52	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN	Ki	4.13	CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL	Ki	4.61	CHEMBL

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External reference:

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ID	Source
001243	NDDF
003194	NDDF
125706008	SNOMEDCT_US
398718007	SNOMEDCT_US
4017797	VUID
4017797	VANDF
517055	PUBCHEM_CID
5206	MMSL
5472	MMSL
56455	RXNORM

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ammonul	HUMAN PRESCRIPTION DRUG LABEL	2	0187-0010	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	NDA	26 sections
Ammonul	HUMAN PRESCRIPTION DRUG LABEL	2	62592-720	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	NDA	28 sections
BEVERHILL HAIR TONIC	HUMAN OTC DRUG LABEL	8	77008-0870	SPRAY	0.08 g	TOPICAL	unapproved drug other	9 sections
BEVERHILL HAIR TONIC	HUMAN OTC DRUG LABEL	8	77008-0870	SPRAY	0.08 g	TOPICAL	unapproved drug other	9 sections
BEVERHILL Micro-Biome Scalp Cooling Essence (Prevention of hair loss, Trouble scalp treatment, Treatment of itching)	HUMAN OTC DRUG LABEL	8	77008-3194	SHAMPOO	0.08 g	TOPICAL	unapproved drug other	7 sections
Oriox Cool Breath Oral Rinse Mild	HUMAN OTC DRUG LABEL	1	77932-001	LIQUID	0.30 g	TOPICAL	unapproved drug other	2 sections
s panax all in one mist	HUMAN OTC DRUG LABEL	1	81885-0002	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections
s panax mist	HUMAN OTC DRUG LABEL	1	76675-0013	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections
s panax mist for refill	HUMAN OTC DRUG LABEL	1	76675-0011	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections
seo jeong ho hwang chill mist	HUMAN OTC DRUG LABEL	1	76675-0006	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections

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