zinc chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4344 7646-85-7

Description:

MoleculeDescription

Synonyms:

  • zinc chloride
  • zinc dichloride
  • Molecular weight: 136.28
  • Formula: Cl2Zn
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 26, 1986 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sedation complication 360.31 13.25 124 14643 8642 50581715
Creatinine renal clearance decreased 327.10 13.25 125 14642 11756 50578601
Blood calcium decreased 281.67 13.25 132 14635 20574 50569783
Orthostatic hypotension 232.11 13.25 130 14637 29351 50561006
Sedation 219.53 13.25 127 14640 30483 50559874
Cognitive disorder 214.73 13.25 143 14624 43980 50546377
Balance disorder 170.98 13.25 151 14616 70439 50519918
Depressed level of consciousness 169.29 13.25 132 14635 51821 50538536
Mobility decreased 160.54 13.25 154 14613 79794 50510563
Constipation 144.79 13.25 221 14546 185487 50404870
Methaemoglobinaemia 141.65 13.25 43 14724 1999 50588358
Fall 58.39 13.25 222 14545 334710 50255647
COVID-19 50.31 13.25 65 14702 46597 50543760
Necrosis ischaemic 47.70 13.25 15 14752 784 50589573
Hypotension 45.95 13.25 162 14605 235307 50355050
Pain 42.40 13.25 301 14466 578602 50011755
Beta haemolytic streptococcal infection 38.94 13.25 16 14751 1814 50588543
Aplastic anaemia 37.49 13.25 25 14742 7678 50582679
Pneumonia streptococcal 37.24 13.25 15 14752 1616 50588741
Skin odour abnormal 31.77 13.25 13 14754 1459 50588898
Norovirus infection 29.72 13.25 8 14759 240 50590117
Toxicity to various agents 29.15 13.25 131 14636 212368 50377989
Lipoedema 28.96 13.25 8 14759 265 50590092
Spinal cord disorder 27.21 13.25 11 14756 1196 50589161
Maternal exposure during pregnancy 26.40 13.25 7 14760 159771 50430586
Acquired diaphragmatic eventration 25.72 13.25 8 14759 403 50589954
Illness 24.60 13.25 33 14734 24507 50565850
Procedural complication 24.31 13.25 16 14751 4807 50585550
Infrapatellar fat pad inflammation 22.93 13.25 6 14761 161 50590196
Wound secretion 22.56 13.25 14 14753 3803 50586554
Death 22.26 13.25 38 14729 325341 50265016
Arthritis infective 22.23 13.25 16 14751 5553 50584804
Terminal insomnia 21.90 13.25 8 14759 661 50589696
Yellow skin 21.74 13.25 11 14756 2018 50588339
Drug interaction 21.64 13.25 16 14751 199605 50390752
Glossodynia 21.23 13.25 4 14763 115565 50474792
Systemic lupus erythematosus 19.99 13.25 8 14759 140614 50449743
Haemorrhagic diathesis 19.66 13.25 13 14754 3935 50586422
Fistula discharge 19.26 13.25 8 14759 932 50589425
Chondropathy 18.54 13.25 10 14757 2090 50588267
Thinking abnormal 18.35 13.25 18 14749 9549 50580808
Endometrial cancer 18.12 13.25 11 14756 2872 50587485
Effusion 18.08 13.25 9 14758 1594 50588763
Copper deficiency 17.61 13.25 4 14763 58 50590299
Discomfort 17.43 13.25 5 14762 108375 50481982
Sneezing 17.42 13.25 21 14746 14023 50576334
Muscle spasms 16.88 13.25 77 14690 125476 50464881
Ocular icterus 16.24 13.25 11 14756 3464 50586893
Bladder spasm 16.05 13.25 8 14759 1422 50588935
White blood cell count decreased 16.00 13.25 72 14695 116650 50473707
Drug ineffective 15.87 13.25 158 14609 819175 49771182
Blood smear test abnormal 15.67 13.25 4 14763 97 50590260
Feeling abnormal 15.44 13.25 75 14692 125417 50464940
Dysphoria 15.24 13.25 12 14755 4762 50585595
Scar 15.20 13.25 18 14749 11800 50578557
Pulmonary pain 14.98 13.25 9 14758 2306 50588051
Abnormal faeces 14.38 13.25 11 14756 4185 50586172
Eyelid margin crusting 14.26 13.25 6 14761 722 50589635
Sacroiliitis 14.03 13.25 9 14758 2588 50587769

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 76.43 16.24 26 5699 2645 29566157
Off label use 66.10 16.24 165 5560 300635 29268167
Rhinocerebral mucormycosis 32.89 16.24 8 5717 243 29568559
Fatigue 25.70 16.24 125 5600 316696 29252106
Aplastic anaemia 23.85 16.24 16 5709 7494 29561308
COVID-19 20.80 16.24 30 5695 35984 29532818
Metal poisoning 17.81 16.24 4 5721 85 29568717

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sedation complication 370.80 13.46 128 16464 10226 64471914
Creatinine renal clearance decreased 332.99 13.46 129 16463 14292 64467848
Blood calcium decreased 289.19 13.46 138 16454 25416 64456724
Sedation 218.79 13.46 135 16457 41327 64440813
Cognitive disorder 213.92 13.46 148 16444 54939 64427201
Orthostatic hypotension 206.40 13.46 136 16456 46602 64435538
Methaemoglobinaemia 204.37 13.46 66 16526 4282 64477858
Mobility decreased 179.52 13.46 160 16432 85680 64396460
Balance disorder 158.97 13.46 148 16444 83778 64398362
Depressed level of consciousness 137.87 13.46 135 16457 81301 64400839
Constipation 129.34 13.46 220 16372 229117 64253023
COVID-19 65.09 13.46 82 16510 65058 64417082
Pain 60.06 13.46 291 16301 553220 63928920
Aplastic anaemia 50.70 13.46 36 16556 13884 64468256
Necrosis ischaemic 46.50 13.46 15 16577 968 64481172
Off label use 46.15 13.46 299 16293 632507 63849633
Fall 42.15 13.46 215 16377 416611 64065529
Beta haemolytic streptococcal infection 36.90 13.46 15 16577 1879 64480261
Skin odour abnormal 33.70 13.46 14 16578 1853 64480287
Pneumonia streptococcal 33.61 13.46 15 16577 2363 64479777
Hypotension 32.72 13.46 188 16404 380786 64101354
Drug interaction 31.62 13.46 28 16564 362055 64120085
Norovirus infection 31.11 13.46 8 16584 228 64481912
Rhinocerebral mucormycosis 29.56 13.46 9 16583 480 64481660
Acquired diaphragmatic eventration 28.16 13.46 9 16583 564 64481576
Copper deficiency 26.01 13.46 6 16586 107 64482033
Infrapatellar fat pad inflammation 23.68 13.46 6 16586 161 64481979
Lipoedema 22.67 13.46 6 16586 192 64481948
Terminal insomnia 20.04 13.46 8 16584 956 64481184
Spinal cord disorder 19.04 13.46 9 16583 1617 64480523
Chondropathy 18.67 13.46 10 16582 2339 64479801
Scar 18.62 13.46 20 16572 13378 64468762
Arthritis infective 18.55 13.46 15 16577 7015 64475125
Pulmonary pain 17.78 13.46 10 16582 2574 64479566
Endometrial cancer 17.66 13.46 9 16583 1901 64480239
Opportunistic infection 17.50 13.46 10 16582 2652 64479488
Effusion 17.41 13.46 9 16583 1959 64480181
Drug ineffective 17.33 13.46 136 16456 840111 63642029
Fatigue 16.85 13.46 278 16314 748452 63733688
Product dose omission issue 15.95 13.46 95 16497 194652 64287488
SARS-CoV-2 test positive 15.72 13.46 13 16579 6273 64475867
Wound secretion 15.60 13.46 12 16580 5220 64476920
Dysphoria 15.18 13.46 11 16581 4377 64477763
Eyelid margin crusting 15.07 13.46 6 16586 712 64481428
Haemorrhagic diathesis 15.05 13.46 12 16580 5502 64476638
Illness 14.97 13.46 23 16569 21915 64460225
Sneezing 14.90 13.46 19 16573 15232 64466908
Cyanosis 14.80 13.46 23 16569 22132 64460008
Cardiac failure 14.49 13.46 8 16584 132365 64349775
Death 14.14 13.46 70 16522 482635 63999505
Sacroiliitis 13.85 13.46 9 16583 3003 64479137
Coma 13.50 13.46 3 16589 87612 64394528
Salpingo-oophorectomy unilateral 13.47 13.46 5 16587 491 64481649

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05XA12 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions
MeSH PA D003358 Cosmetics
MeSH PA D009067 Mouthwashes
CHEBI has role CHEBI:39143 Lewis acid
CHEBI has role CHEBI:48219 disinfectants
CHEBI has role CHEBI:74783 adstringent
CHEBI has role CHEBI:86385 Delta(7)-cholestenol Delta(7)-Delta(8)-isomerase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Zinc deficiency indication 238124008
Local anesthesia indication 386761002
Mouth Irritation indication
Suppression of the Gag Reflex indication
Hereditary acrodermatitis enteropathica off-label use 37702000
Cerebral trauma off-label use 275382005
Hypocupremia contraindication 19577007
Methemoglobinemia contraindication 38959009 DOID:10783
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter Ki 5.16 DRUG MATRIX
Carbonic anhydrase 2 Enzyme IC50 5.94 DRUG MATRIX
Epidermal growth factor receptor Kinase IC50 5.66 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.73 DRUG MATRIX
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme IC50 5.96 DRUG MATRIX
G-protein coupled receptor 39 GPCR EC50 8.44 CHEMBL
Ubiquitin-conjugating enzyme E2 T Enzyme Kd 4.80 CHEMBL
Androgen receptor Transcription factor Ki 5.36 DRUG MATRIX
G protein-coupled receptor 39-1b GPCR EC50 5.39 CHEMBL

External reference:

IDSource
4018532 VUID
N0000146854 NUI
D02058 KEGG_DRUG
4018532 VANDF
C0078774 UMLSCUI
CHEBI:49976 CHEBI
CHEMBL1200679 ChEMBL_ID
DB14533 DRUGBANK_ID
C016837 MESH_SUPPLEMENTAL_RECORD_UI
86Q357L16B UNII
5727 PUBCHEM_CID
39937 RXNORM
1505 MMSL
5707 MMSL
d04055 MMSL
000842 NDDF
001942 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 0363-0607 CREAM 0.15 g ORAL OTC monograph not final 9 sections
3x Medicated Mouth Sore Gel HUMAN OTC DRUG LABEL 3 0363-1605 GEL 0.15 g ORAL OTC monograph not final 7 sections
Walgreens Instant Toothache and Gum ReliefTriple Medicated HUMAN OTC DRUG LABEL 3 0363-5351 GEL 0.15 g TOPICAL OTC monograph not final 12 sections
4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 0363-6008 GEL 0.15 g ORAL OTC monograph not final 9 sections
ZINC HUMAN PRESCRIPTION DRUG LABEL 1 0409-4090 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 20 sections
KANKA SoftBrush HUMAN OTC DRUG LABEL 2 10157-2106 GEL 0.10 g ORAL OTC MONOGRAPH NOT FINAL 12 sections
Orajel Instant Pain ReliefMaximum Strength HUMAN OTC DRUG LABEL 3 10237-708 GEL 1 mg TOPICAL OTC monograph not final 8 sections
Orajel 3X Medicated for Denture Pain HUMAN OTC DRUG LABEL 3 10237-723 GEL 1.50 mg TOPICAL OTC monograph not final 12 sections
Orajel Toothache Rinse HUMAN OTC DRUG LABEL 2 10237-764 LIQUID 1.50 mg TOPICAL OTC monograph not final 11 sections
Orajel 3X Medicated For All Mouth Sores HUMAN OTC DRUG LABEL 3 10237-783 GEL 1.50 mg TOPICAL OTC monograph not final 12 sections
Orajel 4X Medicated For Toothache and Gum HUMAN OTC DRUG LABEL 4 10237-787 GEL 1.50 mg TOPICAL OTC monograph not final 12 sections
Orajel 4X Medicated PM For Toothache and Gum HUMAN OTC DRUG LABEL 4 10237-789 CREAM 1.50 mg TOPICAL OTC monograph not final 12 sections
Orajel 3X Medicated For Toothache and Gum HUMAN OTC DRUG LABEL 3 10237-790 GEL 1.50 mg TOPICAL OTC monograph not final 12 sections
Orajel Gum Pain 3X Medicated HUMAN OTC DRUG LABEL 3 10237-792 GEL 1.50 mg TOPICAL OTC monograph not final 12 sections
Rite AidMaximum Strength HUMAN OTC DRUG LABEL 3 11822-0317 GEL, DENTIFRICE 0.10 g ORAL OTC monograph not final 9 sections
3X Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 3 11822-0613 GEL 0.15 g ORAL OTC monograph not final 11 sections
4X Medicated Severe Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 11822-0614 CREAM 0.15 g ORAL OTC monograph not final 10 sections
4X Medicated Severe Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 11822-0615 GEL 0.15 g ORAL OTC monograph not final 10 sections
Rite Aid Severe Toothache and Gum ReliefTriple Medicated HUMAN OTC DRUG LABEL 3 11822-6037 CREAM 0.15 g TOPICAL OTC monograph not final 12 sections
Rite Aid Severe Toothache and Gum ReliefTriple Medicated HUMAN OTC DRUG LABEL 3 11822-6038 GEL 0.15 g TOPICAL OTC monograph not final 12 sections
3X Medicated Mouth Sore Gel HUMAN OTC DRUG LABEL 3 11822-6170 GEL 0.15 g ORAL OTC monograph not final 8 sections
4x Medicated Gum Cream HUMAN OTC DRUG LABEL 4 21130-621 CREAM 0.15 g ORAL OTC monograph not final 9 sections
KDS LabLiquid Styptic HUMAN OTC DRUG LABEL 3 24488-040 LIQUID 400.02 mg TOPICAL OTC monograph not final 13 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 30142-212 CREAM 0.15 g ORAL OTC monograph not final 9 sections
Severe Triple Medicated Gel HUMAN OTC DRUG LABEL 3 36800-389 GEL 0.15 g ORAL OTC monograph not final 9 sections
Topco 4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 36800-624 GEL 0.15 g ORAL OTC monograph not final 9 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 37808-116 CREAM 0.15 g ORAL OTC monograph not final 10 sections
HEB Mouth Sore Relief HUMAN OTC DRUG LABEL 3 37808-312 GEL 0.10 g TOPICAL OTC monograph not final 12 sections
3x Medicated Mouth Sore Gel HUMAN OTC DRUG LABEL 3 37808-691 GEL 0.15 g ORAL OTC monograph not final 11 sections
G-BUCAL-C HUMAN OTC DRUG LABEL 2 43913-402 SPRAY 30 mg OROPHARYNGEAL OTC MONOGRAPH NOT FINAL 9 sections