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zinc chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4344	7646-85-7

Description:

Molecule	Description
Synonyms: zinc chloride zinc dichloride	Molecular weight: 136.28 Formula: Cl2Zn CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

zinc chloride
zinc dichloride

Molecular weight: 136.28
Formula: Cl2Zn
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 26, 1986	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	493.46	12.29	191	24978	13631	63450222
Creatinine renal clearance decreased	466.24	12.29	192	24977	16116	63447737
Blood calcium decreased	403.82	12.29	201	24968	26250	63437603
Orthostatic hypotension	336.87	12.29	198	24971	35962	63427891
Sedation	323.91	12.29	198	24971	38611	63425242
Cognitive disorder	294.47	12.29	214	24955	55601	63408252
Depressed level of consciousness	244.26	12.29	200	24969	61878	63401975
Balance disorder	243.70	12.29	228	24941	84194	63379659
Mobility decreased	193.26	12.29	239	24930	120920	63342933
Gastrointestinal toxicity	180.79	12.29	79	25090	7662	63456191

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	135.20	14.75	45	8137	3536	34945213
Off label use	71.22	14.75	237	7945	419287	34529462
Rhinocerebral mucormycosis	56.03	14.75	15	8167	553	34948196
COVID-19	51.19	14.75	76	8106	77474	34871275
Radiation inflammation	40.74	14.75	13	8169	892	34947857
Pulmonary pain	36.89	14.75	13	8169	1211	34947538
Product dose omission issue	30.03	14.75	78	8104	119633	34829116
Fatigue	22.59	14.75	156	8026	370497	34578252
Copper deficiency	22.45	14.75	4	8178	19	34948730
Aplastic anaemia	21.53	14.75	18	8164	9698	34939051

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	513.71	12.03	195	26820	15474	79701899
Creatinine renal clearance decreased	480.64	12.03	196	26819	18806	79698567
Blood calcium decreased	416.20	12.03	207	26808	31612	79685761
Sedation	316.76	12.03	205	26810	51690	79665683
Orthostatic hypotension	299.61	12.03	204	26811	55960	79661413
Cognitive disorder	292.47	12.03	219	26796	69707	79647666
Methaemoglobinaemia	244.68	12.03	86	26929	5471	79711902
Balance disorder	237.77	12.03	225	26790	98632	79618741
Mobility decreased	216.92	12.03	236	26779	121939	79595434
Depressed level of consciousness	202.49	12.03	204	26811	96448	79620925

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	B05XA12	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTION ADDITIVES Electrolyte solutions
CHEBI has role	CHEBI:39143	Lewis acid
CHEBI has role	CHEBI:48219	disinfectants
CHEBI has role	CHEBI:74783	adstringent
CHEBI has role	CHEBI:86385	Delta(7)-cholestenol Delta(7)-Delta(8)-isomerase inhibitors
MeSH PA	D003358	Cosmetics
MeSH PA	D009067	Mouthwashes

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Zinc deficiency	indication	238124008
Local anesthesia	indication	386761002
Mouth Irritation	indication
Suppression of the Gag Reflex	indication
Hereditary acrodermatitis enteropathica	off-label use	37702000
Cerebral trauma	off-label use	275382005
Hypocupremia	contraindication	19577007
Methemoglobinemia	contraindication	38959009	DOID:10783
Wilson's disease	contraindication	88518009
Anemia due to enzyme deficiency	contraindication	111577008

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	Ki	5.16	DRUG MATRIX
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN	IC50	5.94	DRUG MATRIX
Epidermal growth factor receptor	Kinase	P00533	EGFR_HUMAN	IC50	5.66	DRUG MATRIX
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN	IC50	5.73	DRUG MATRIX
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Enzyme	Q08209	PP2BA_HUMAN	IC50	5.96	DRUG MATRIX
G-protein coupled receptor 39	GPCR	O43194	GPR39_HUMAN	EC50	8.44	CHEMBL
Ubiquitin-conjugating enzyme E2 T	Enzyme	Q9NPD8	UBE2T_HUMAN	Kd	4.80	CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT	Ki	5.36	DRUG MATRIX
G protein-coupled receptor 39-1b	GPCR		A6QR73_RAT	EC50	5.39	CHEMBL

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External reference:

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ID	Source
000842	NDDF
001942	NDDF
1505	MMSL
39937	RXNORM
4018532	VUID
4018532	VANDF
5707	MMSL
5727	PUBCHEM_CID
86Q357L16B	UNII
C0078774	UMLSCUI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
3x Medicated Mouth Sore Gel	HUMAN OTC DRUG LABEL	3	0363-1605	GEL	0.15 g	ORAL	OTC monograph not final	7 sections
3x Medicated Mouth Sore Gel	HUMAN OTC DRUG LABEL	3	0363-1605	GEL	0.15 g	ORAL	OTC monograph not final	7 sections
3X Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	3	11822-0613	GEL	0.15 g	ORAL	OTC monograph not final	11 sections
3X Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	3	11822-0613	GEL	0.15 g	ORAL	OTC monograph not final	11 sections
4X Medicated Severe Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	11822-0614	CREAM	0.15 g	ORAL	OTC monograph not final	11 sections
4X Medicated Severe Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	11822-0614	CREAM	0.15 g	ORAL	OTC monograph not final	11 sections
4x Medicated Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	0363-0607	CREAM	0.15 g	ORAL	OTC monograph not final	9 sections
4x Medicated Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	0363-0607	CREAM	0.15 g	ORAL	OTC monograph not final	9 sections
4x Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	4	0363-6008	GEL	0.15 g	ORAL	OTC monograph not final	9 sections
4x Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	4	0363-6008	GEL	0.15 g	ORAL	OTC monograph not final	9 sections

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