zinc chloride Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4344 7646-85-7

Description:

MoleculeDescription

Synonyms:

  • zinc chloride
  • zinc dichloride
  • Molecular weight: 136.28
  • Formula: Cl2Zn
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 26, 1986 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 144.18 14.15 42 10884 2120 46673016
Sedation complication 81.28 14.15 31 10895 3614 46671522
Creatinine renal clearance decreased 62.17 14.15 31 10895 6889 46668247
Necrosis ischaemic 50.14 14.15 15 10911 830 46674306
Blood calcium decreased 49.94 14.15 36 10890 15637 46659499
Sedation 49.88 14.15 42 10884 22868 46652268
Orthostatic hypotension 49.20 14.15 43 10883 24615 46650521
Beta haemolytic streptococcal infection 45.50 14.15 17 10909 1872 46673264
Constipation 43.25 14.15 113 10813 173984 46501152
Cognitive disorder 41.35 14.15 47 10879 36836 46638300
Mobility decreased 40.82 14.15 60 10866 60534 46614602
Pneumonia streptococcal 39.90 14.15 15 10911 1680 46673456
Lipoedema 34.57 14.15 8 10918 160 46674976
Balance disorder 32.57 14.15 56 10870 64465 46610671
Skin odour abnormal 27.11 14.15 11 10915 1508 46673628
Aplastic anaemia 26.44 14.15 18 10908 7135 46668001
Yellow skin 23.87 14.15 11 10915 2053 46673083
Hidradenitis 23.61 14.15 11 10915 2104 46673032
Spinal cord disorder 22.98 14.15 9 10917 1125 46674011
Neonatal infection 22.85 14.15 6 10920 205 46674931
Procedural complication 22.11 14.15 14 10912 4916 46670220
Muscle spasms 21.93 14.15 71 10855 123042 46552094
Endometrial cancer 21.44 14.15 11 10915 2592 46672544
Fistula discharge 21.10 14.15 8 10918 917 46674219
Scar 20.12 14.15 19 10907 12000 46663136
Abnormal faeces 19.42 14.15 12 10914 4037 46671099
Depressed level of consciousness 18.60 14.15 37 10889 47532 46627604
Ocular icterus 18.00 14.15 11 10915 3629 46671507
Fatigue 17.91 14.15 219 10707 608478 46066658
Bladder spasm 17.47 14.15 8 10918 1471 46673665
Wound secretion 17.35 14.15 11 10915 3869 46671267
Cyanosis 17.30 14.15 20 10906 15951 46659185
Drug interaction 16.47 14.15 14 10912 203080 46472056
Pain 16.42 14.15 177 10749 476771 46198365
Hepato-lenticular degeneration 15.85 14.15 3 10923 21 46675115
Sneezing 15.58 14.15 17 10909 12724 46662412
COVID-19 14.88 14.15 20 10906 18555 46656581
Feeling abnormal 14.62 14.15 63 10863 124997 46550139
Death 14.53 14.15 36 10890 335512 46339624

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 73.13 15.21 24 5081 2486 29944887
Postural tremor 22.65 15.21 6 5099 294 29947079
Metal poisoning 18.36 15.21 4 5101 84 29947289
Copper deficiency 18.21 15.21 3 5102 12 29947361
Neurological decompensation 16.43 15.21 8 5097 2320 29945053
Fatigue 15.89 15.21 101 5004 320572 29626801

Pharmacologic Action:

SourceCodeDescription
ATC B05XA12 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions
MeSH PA D003358 Cosmetics
MeSH PA D009067 Mouthwashes
CHEBI has role CHEBI:39143 lewis acid
CHEBI has role CHEBI:48219 disinfectants
CHEBI has role CHEBI:74783 astringents
CHEBI has role CHEBI:86385 ec 5.3.3.5 inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Zinc deficiency indication 238124008
Local anesthesia indication 386761002
Mouth Irritation indication
Suppression of the Gag Reflex indication
Hereditary acrodermatitis enteropathica off-label use 37702000
Cerebral trauma off-label use 275382005
Hypocupremia contraindication 19577007
Methemoglobinemia contraindication 38959009 DOID:10783
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter Ki 5.16 DRUG MATRIX
Carbonic anhydrase 2 Enzyme IC50 5.94 DRUG MATRIX
Epidermal growth factor receptor Kinase IC50 5.66 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.73 DRUG MATRIX
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme IC50 5.96 DRUG MATRIX
G-protein coupled receptor 39 GPCR EC50 8.44 CHEMBL
Androgen receptor Transcription factor Ki 5.36 DRUG MATRIX
G protein-coupled receptor 39-1b Unclassified EC50 5.39 CHEMBL

External reference:

IDSource
4018532 VUID
N0000146854 NUI
D02058 KEGG_DRUG
4018532 VANDF
C0078774 UMLSCUI
CHEBI:49976 CHEBI
CHEMBL1200679 ChEMBL_ID
C016837 MESH_SUPPLEMENTAL_RECORD_UI
86Q357L16B UNII
5727 PUBCHEM_CID
DB14533 DRUGBANK_ID
39937 RXNORM
1505 MMSL
5707 MMSL
d04055 MMSL
000842 NDDF
001942 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 0363-0607 CREAM 0.15 g ORAL OTC monograph not final 10 sections
Walgreens Instant Toothache and Gum Relief Triple Medicated HUMAN OTC DRUG LABEL 3 0363-5350 CREAM 0.15 g TOPICAL OTC monograph not final 12 sections
Walgreens Instant Toothache and Gum Relief Triple Medicated HUMAN OTC DRUG LABEL 3 0363-5351 GEL 0.15 g TOPICAL OTC monograph not final 12 sections
4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 0363-6008 GEL 0.15 g ORAL OTC monograph not final 10 sections
ZINC HUMAN PRESCRIPTION DRUG LABEL 1 0409-4090 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 20 sections
KANKA SoftBrush HUMAN OTC DRUG LABEL 2 10157-2106 GEL 0.10 g ORAL OTC MONOGRAPH NOT FINULLL 12 sections
Orajel Instant Pain ReliefMaximum Strength HUMAN OTC DRUG LABEL 3 10237-708 GEL 1 mg TOPICAL OTC monograph not final 8 sections
Orajel 3X Medicated for Denture Pain HUMAN OTC DRUG LABEL 3 10237-723 GEL 1.50 mg TOPICAL OTC monograph not final 12 sections
Orajel Toothache Rinse HUMAN OTC DRUG LABEL 2 10237-764 LIQUID 1.62 mg TOPICAL OTC monograph not final 11 sections
Benzocaine, Menthol, Zinc Chloride HUMAN OTC DRUG LABEL 3 10237-768 CREAM 1.50 mg TOPICAL OTC monograph not final 11 sections
Benzocaine, Menthol, Zinc Chloride HUMAN OTC DRUG LABEL 3 10237-769 GEL 2.50 mg TOPICAL OTC monograph not final 11 sections
Benzocaine, Menthol, Zinc Chloride HUMAN OTC DRUG LABEL 3 10237-771 CREAM 1.50 mg TOPICAL OTC monograph not final 11 sections
Orajel 3X Medicated For All Mouth Sores HUMAN OTC DRUG LABEL 3 10237-783 GEL 1.50 mg TOPICAL OTC monograph not final 11 sections
Orajel 4X Medicated For Toothache and Gum HUMAN OTC DRUG LABEL 4 10237-787 GEL 1.50 mg TOPICAL OTC monograph not final 12 sections
Orajel 4X Medicated PM For Toothache and Gum HUMAN OTC DRUG LABEL 4 10237-789 CREAM 1.50 mg TOPICAL OTC monograph not final 12 sections
Orajel 3X Medicated For Toothache and Gum HUMAN OTC DRUG LABEL 3 10237-790 GEL 1.50 mg TOPICAL OTC monograph not final 12 sections
Orajel Gum Pain 3X Medicated HUMAN OTC DRUG LABEL 3 10237-792 GEL 1.50 mg TOPICAL OTC monograph not final 12 sections
Rite AidMaximum Strength HUMAN OTC DRUG LABEL 3 11822-0317 GEL, DENTIFRICE 0.10 g ORAL OTC monograph not final 9 sections
3X Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 3 11822-0613 GEL 0.15 g ORAL OTC monograph not final 11 sections
4X Medicated Severe Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 11822-0614 CREAM 0.15 g ORAL OTC monograph not final 11 sections
4X Medicated Severe Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 11822-0615 GEL 0.15 g ORAL OTC monograph not final 11 sections
Rite Aid Severe Toothache and Gum Relief Triple Medicated HUMAN OTC DRUG LABEL 3 11822-6037 CREAM 0.15 g TOPICAL OTC monograph not final 12 sections
Rite Aid Severe Toothache and Gum Relief Triple Medicated HUMAN OTC DRUG LABEL 3 11822-6038 GEL 0.15 g TOPICAL OTC monograph not final 12 sections
3X Medicated Mouth Sore Gel HUMAN OTC DRUG LABEL 3 11822-6170 GEL 0.15 g ORAL OTC monograph not final 9 sections
4x Medicated Gum Cream HUMAN OTC DRUG LABEL 4 21130-621 CREAM 0.15 g ORAL OTC monograph not final 9 sections
KDS LabLiquid Styptic HUMAN OTC DRUG LABEL 3 24488-040 LIQUID 400.02 mg TOPICAL OTC monograph not final 13 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 30142-212 CREAM 0.15 g ORAL OTC monograph not final 9 sections
Severe Triple Medicated Gel HUMAN OTC DRUG LABEL 3 36800-389 GEL 0.15 g ORAL OTC monograph not final 9 sections
Topco 4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 36800-624 GEL 0.15 g ORAL OTC monograph not final 9 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 37808-116 CREAM 0.15 g ORAL OTC monograph not final 10 sections