zinc chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4344 7646-85-7

Description:

MoleculeDescription

Synonyms:

  • zinc chloride
  • zinc dichloride
  • Molecular weight: 136.28
  • Formula: Cl2Zn
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 26, 1986 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sedation complication 495.70 11.58 212 41656 16732 90569847
Creatinine renal clearance decreased 483.05 11.58 215 41653 18684 90567895
Blood calcium decreased 409.66 11.58 223 41645 29959 90556620
Orthostatic hypotension 332.48 11.58 219 41649 41608 90544971
Sedation 309.07 11.58 221 41647 47950 90538629
Cognitive disorder 271.65 11.58 238 41630 69169 90517410
Balance disorder 242.33 11.58 260 41608 96820 90489759
Depressed level of consciousness 232.95 11.58 223 41645 72561 90514018
Gastrointestinal toxicity 171.65 11.58 85 41783 9382 90577197
Constipation 154.94 11.58 376 41492 280019 90306560
Pulmonary toxicity 153.08 11.58 84 41784 11447 90575132
Mobility decreased 144.72 11.58 342 41526 250392 90336187
Amyloid arthropathy 110.65 11.58 38 41830 1642 90584937
Joint injury 104.29 11.58 100 41768 32564 90554015
Methaemoglobinaemia 103.58 11.58 46 41822 3969 90582610
Neoplasm malignant 101.20 11.58 100 41768 33780 90552799
Pulmonary pain 92.96 11.58 46 41822 5068 90581511
Fall 85.07 11.58 443 41425 481367 90105212
Renal function test abnormal 75.62 11.58 45 41823 7146 90579433
Creatinine renal clearance increased 73.28 11.58 34 41834 3247 90583332
Hepatotoxicity 68.83 11.58 95 41773 45747 90540832
Macular degeneration 68.32 11.58 86 41782 37884 90548695
COVID-19 62.76 11.58 196 41672 168647 90417932
Product label confusion 60.13 11.58 63 41805 22787 90563792
Joint stiffness 56.86 11.58 117 41751 77925 90508654
Multiple drug therapy 53.96 11.58 36 41832 6973 90579606
Acute kidney injury 51.99 11.58 43 41825 320344 90266235
Onychomycosis 49.55 11.58 73 41795 37303 90549276
Chronic sinusitis 49.47 11.58 58 41810 23744 90562835
Female genital tract fistula 48.34 11.58 50 41818 17818 90568761
Copper deficiency 46.72 11.58 11 41857 115 90586464
Finger deformity 44.69 11.58 65 41803 32832 90553747
Death 41.93 11.58 93 41775 456458 90130121
Rheumatoid factor positive 41.07 11.58 14 41854 171636 90414943
C-reactive protein abnormal 38.51 11.58 138 41730 127291 90459288
Necrosis ischaemic 37.74 11.58 15 41853 980 90585599
Hypotension 37.45 11.58 268 41600 325129 90261450
Pain 37.18 11.58 656 41212 995685 89590894
Therapeutic product effect incomplete 35.99 11.58 181 41687 193715 90392864
Taste disorder 35.47 11.58 84 41784 61462 90525117
Paraesthesia oral 35.18 11.58 57 41811 31602 90554977
Musculoskeletal pain 34.75 11.58 164 41704 171087 90415492
Salpingo-oophorectomy unilateral 34.66 11.58 14 41854 954 90585625
Discomfort 34.19 11.58 46 41822 274289 90312290
Adverse reaction 32.35 11.58 53 41815 29659 90556920
Thrombocytopenia 31.45 11.58 30 41838 208695 90377884
Sleep disorder due to general medical condition, insomnia type 29.92 11.58 11 41857 128683 90457896
Carbuncle 29.36 11.58 14 41854 1422 90585157
Procedural pain 29.14 11.58 54 41814 33306 90553273
Skin odour abnormal 28.95 11.58 15 41853 1820 90584759
Toxicity to various agents 28.56 11.58 229 41639 287617 90298962
Dermatitis atopic 28.48 11.58 44 41824 23428 90563151
Vaginal flatulence 28.29 11.58 32 41836 12606 90573973
Pemphigus 28.04 11.58 69 41799 326795 90259784
Sinusitis fungal 27.99 11.58 15 41853 1949 90584630
Cardiac arrest 27.95 11.58 7 41861 104928 90481651
Wound secretion 27.71 11.58 21 41847 4969 90581610
Neck pain 27.55 11.58 115 41753 113848 90472731
Beta haemolytic streptococcal infection 27.10 11.58 16 41852 2503 90584076
Monoclonal immunoglobulin present 26.89 11.58 15 41853 2109 90584470
Pneumonia streptococcal 26.78 11.58 15 41853 2126 90584453
Obesity 26.71 11.58 108 41760 105399 90481180
Proctitis 26.56 11.58 34 41834 15225 90571354
Nail disorder 26.15 11.58 73 41795 58994 90527585
Onychomadesis 25.66 11.58 62 41806 45936 90540643
Intentional overdose 25.50 11.58 6 41862 93828 90492751
Congenital anomaly 25.27 11.58 22 41846 6325 90580254
Illness 24.95 11.58 89 41779 81880 90504699
Glossodynia 24.53 11.58 72 41796 321707 90264872
Product dose omission issue 24.18 11.58 223 41645 291464 90295115
Hypothalamo-pituitary disorder 23.44 11.58 14 41854 2238 90584341
Lipoedema 23.40 11.58 8 41860 341 90586238
Hypokalaemia 23.30 11.58 16 41852 131100 90455479
Product use in unapproved indication 23.00 11.58 247 41621 335989 90250590
Product use issue 22.91 11.58 77 41791 329842 90256737
Radiculopathy 22.89 11.58 35 41833 18470 90568109
Sputum increased 22.31 11.58 15 41853 2942 90583637
Aplastic anaemia 22.21 11.58 29 41839 13240 90573339
Muscle spasms 22.11 11.58 195 41673 251688 90334891
Sinus pain 22.11 11.58 19 41849 5370 90581209
Pulmonary fibrosis 22.10 11.58 11 41857 107492 90479087
Contraindicated product administered 22.03 11.58 75 41793 320064 90266515
Back injury 22.01 11.58 59 41809 46563 90540016
Therapy non-responder 21.53 11.58 122 41746 136582 90449997
Drug abuse 21.41 11.58 85 41783 82262 90504317
Neutropenia 21.29 11.58 45 41823 224859 90361720
Pain in extremity 20.97 11.58 308 41560 450221 90136358
Tenderness 20.41 11.58 41 41827 26827 90559752
Hyponatraemia 20.34 11.58 19 41849 133519 90453060
Acquired diaphragmatic eventration 19.74 11.58 8 41860 550 90586029
Spinal cord disorder 19.67 11.58 11 41857 1554 90585025
Embolism venous 19.58 11.58 15 41853 3605 90582974
Osteoarthritis 19.01 11.58 155 41713 195575 90391004
Musculoskeletal stiffness 18.97 11.58 215 41653 296317 90290262
Oral candidiasis 18.94 11.58 47 41821 35408 90551171
Vaginal discharge 18.91 11.58 33 41835 19431 90567148
Hand deformity 18.69 11.58 72 41796 296290 90290289
Nasal polyps 18.55 11.58 24 41844 10856 90575723
Infrapatellar fat pad inflammation 18.28 11.58 6 41862 225 90586354
Red blood cell sedimentation rate decreased 17.79 11.58 9 41859 1039 90585540
Fistula discharge 17.57 11.58 9 41859 1066 90585513
Blepharospasm 17.56 11.58 61 41807 55384 90531195
Respiratory symptom 17.46 11.58 15 41853 4237 90582342
Systemic lupus erythematosus 17.44 11.58 97 41771 361799 90224780
Electrocardiogram QT prolonged 17.17 11.58 6 41862 72450 90514129
Diastolic dysfunction 17.15 11.58 19 41849 7314 90579265
Procedural complication 16.90 11.58 17 41851 5861 90580718
Rhinocerebral mucormycosis 16.86 11.58 8 41860 804 90585775
Overweight 16.77 11.58 17 41851 5917 90580662
Suicide attempt 16.61 11.58 7 41861 75392 90511187
Wrist deformity 16.61 11.58 13 41855 3225 90583354
Electrocardiogram PR shortened 16.58 11.58 7 41861 534 90586045
Heart rate variability increased 16.48 11.58 4 41864 48 90586531
Gastrointestinal candidiasis 16.42 11.58 6 41862 311 90586268
Pyrexia 16.40 11.58 211 41657 660274 89926305
Sepsis 16.17 11.58 37 41831 179777 90406802
Hyperkalaemia 16.06 11.58 5 41863 64959 90521620
Angioedema 16.03 11.58 5 41863 64871 90521708
Overdose 15.91 11.58 126 41742 157583 90428996
Arthritis infective 15.82 11.58 19 41849 7973 90578606
Vertebral lateral recess stenosis 15.81 11.58 6 41862 346 90586233
General physical health deterioration 15.61 11.58 98 41770 355017 90231562
Hepatic enzyme decreased 15.60 11.58 8 41860 950 90585629
Swollen joint count increased 15.59 11.58 17 41851 111189 90475390
Febrile neutropenia 15.56 11.58 31 41837 158318 90428261
Osteoarthropathy 15.55 11.58 6 41862 362 90586217
Pericarditis 15.55 11.58 68 41800 270083 90316496
Myelosuppression 15.43 11.58 3 41865 53588 90532991
Ligamentum flavum hypertrophy 15.41 11.58 6 41862 371 90586208
Vomiting 15.37 11.58 264 41604 788029 89798550
Hip arthroplasty 15.36 11.58 8 41860 76200 90510379
Chronic inflammatory demyelinating polyradiculoneuropathy 14.93 11.58 8 41860 1039 90585540
Fibrosis 14.93 11.58 16 41852 5936 90580643
Yellow skin 14.26 11.58 11 41857 2670 90583909
Eczema 14.08 11.58 55 41813 52815 90533764
Product dose omission in error 14.06 11.58 30 41838 20473 90566106
Coeliac disease 14.06 11.58 49 41819 44561 90542018
Blood smear test abnormal 14.01 11.58 4 41864 93 90586486
Limb injury 14 11.58 39 41829 31469 90555110
Drug interaction 13.92 11.58 73 41795 276380 90310199
Terminal insomnia 13.82 11.58 8 41860 1207 90585372
Synovial fluid analysis 13.78 11.58 11 41857 2807 90583772
Cardio-respiratory arrest 13.69 11.58 6 41862 63134 90523445
Abortion spontaneous 13.65 11.58 4 41864 54052 90532527
Migraine 13.53 11.58 141 41727 190251 90396328
Memory impairment 13.51 11.58 145 41723 197099 90389480
Abnormal faeces 13.42 11.58 16 41852 6666 90579913
Endometrial cancer 13.35 11.58 12 41856 3600 90582979
Product quality issue 13.29 11.58 72 41796 79253 90507326
Breast cancer stage III 13.05 11.58 75 41793 84372 90502207
Product administration error 13.04 11.58 34 41834 26389 90560190
Cardiac failure 12.99 11.58 19 41849 109477 90477102
Allergy to chemicals 12.95 11.58 12 41856 3742 90582837
Incorrect product administration duration 12.94 11.58 28 41840 19294 90567285
Synovial disorder 12.80 11.58 11 41857 3107 90583472
Bladder disorder 12.80 11.58 20 41848 10752 90575827
Pleural effusion 12.74 11.58 20 41848 111971 90474608
Chondropathy 12.70 11.58 10 41858 2502 90584077
Bradycardia 12.68 11.58 12 41856 83835 90502744
Bone density decreased 12.62 11.58 26 41842 17319 90569260
Metabolic acidosis 12.54 11.58 5 41863 55671 90530908
Confusional state 12.52 11.58 116 41752 386089 90200490
Synovitis 12.52 11.58 95 41773 329657 90256922
Tenosynovitis stenosans 12.42 11.58 12 41856 3941 90582638
Dyspepsia 12.36 11.58 143 41725 198017 90388562
Appetite disorder 12.34 11.58 18 41850 9115 90577464
Scar 12.31 11.58 24 41844 15371 90571208
Bladder spasm 12.29 11.58 9 41859 2021 90584558
Osmophobia 12.27 11.58 4 41864 147 90586432
Antiacetylcholine receptor antibody positive 12.21 11.58 4 41864 149 90586430
Effusion 12.17 11.58 9 41859 2053 90584526
Disinhibition 12.06 11.58 7 41861 1061 90585518
Disease progression 11.95 11.58 35 41833 156580 90429999
Lack of infusion site rotation 11.87 11.58 4 41864 163 90586416
Calcitonin secretion disorder 11.87 11.58 3 41865 43 90586536
Pregnancy 11.80 11.58 7 41861 62040 90524539
Hysterectomy 11.72 11.58 20 41848 11564 90575015

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 109.63 13.88 45 11030 5729 42604531
Radiation inflammation 57.73 13.88 18 11057 1030 42609230
Pulmonary pain 54.31 13.88 19 11056 1559 42608701
Copper deficiency 47.22 13.88 8 11067 23 42610237
Rhinocerebral mucormycosis 47.20 13.88 14 11061 676 42609584
Off label use 43.27 13.88 298 10777 638037 41972223
Genital pain 35.37 13.88 12 11063 898 42609362
COVID-19 34.47 13.88 86 10989 115862 42494398
Genital ulceration 31.71 13.88 11 11064 880 42609380
Product dose omission issue 27.16 13.88 95 10980 154270 42455990
Injection site pain 26.43 13.88 51 11024 57747 42552513
Food poisoning 22.75 13.88 12 11063 2694 42607566
Toxicity to various agents 22.60 13.88 16 11059 229120 42381140
Irritable bowel syndrome 21.43 13.88 14 11061 4667 42605593
Fatigue 21.34 13.88 189 10886 435452 42174808
Illness 20.97 13.88 29 11046 24901 42585359
Arthropathy 19.93 13.88 31 11044 29566 42580694
Dermatitis atopic 19.74 13.88 20 11055 12384 42597876
Gastrointestinal pain 19.71 13.88 13 11062 4402 42605858
Product preparation error 18.78 13.88 13 11062 4765 42605495
Aplastic anaemia 17.97 13.88 19 11056 12365 42597895
Schizophrenia 16.77 13.88 17 11058 10533 42599727
Metal poisoning 16.34 13.88 4 11071 92 42610168
Vascular device infection 15.93 13.88 13 11062 6097 42604163
Lung neoplasm malignant 15.69 13.88 22 11053 19125 42591135
Knee arthroplasty 15.54 13.88 15 11060 8766 42601494
Intentional product misuse 15.40 13.88 43 11032 61857 42548403
Injection site swelling 14.66 13.88 20 11055 16953 42593307
Oral pain 14.29 13.88 17 11058 12579 42597681
Rash 13.95 13.88 121 10954 276833 42333427

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sedation complication 497.63 11.49 215 45093 19640 110524351
Creatinine renal clearance decreased 487.76 11.49 218 45090 21597 110522394
Blood calcium decreased 412.47 11.49 228 45080 35617 110508374
Orthostatic hypotension 276.34 11.49 224 45084 66025 110477966
Sedation 270.56 11.49 226 45082 69457 110474534
Cognitive disorder 262.19 11.49 245 45063 87266 110456725
Balance disorder 223.77 11.49 257 45051 116303 110427688
Methaemoglobinaemia 193.38 11.49 88 45220 9080 110534911
Mobility decreased 184.67 11.49 341 44967 237081 110306910
Depressed level of consciousness 183.33 11.49 228 45080 112050 110431941
Constipation 148.84 11.49 400 44908 357386 110186605
Pulmonary pain 147.40 11.49 65 45243 6228 110537763
Amyloid arthropathy 115.13 11.49 38 45270 1642 110542349
Completed suicide 85.91 11.49 3 45305 242378 110301613
Acute kidney injury 81.66 11.49 84 45224 635346 109908645
Copper deficiency 79.78 11.49 18 45290 175 110543816
COVID-19 78.72 11.49 250 45058 244810 110299181
Pain 74.03 11.49 654 44654 954301 109589690
Creatinine renal clearance increased 73.95 11.49 34 45274 3591 110540400
Renal function test abnormal 69.04 11.49 44 45264 8902 110535089
Fall 67.19 11.49 450 44858 603032 109940959
Product label confusion 66.91 11.49 63 45245 22614 110521377
Gastrointestinal toxicity 60.26 11.49 44 45264 11104 110532887
Rhinocerebral mucormycosis 57.09 11.49 22 45286 1495 110542496
Female genital tract fistula 56.78 11.49 50 45258 16469 110527522
Onychomycosis 56.15 11.49 74 45234 38457 110505534
Multiple drug therapy 53.50 11.49 36 45272 7978 110536013
Chronic sinusitis 50.95 11.49 57 45251 25027 110518964
Finger deformity 50.47 11.49 65 45243 33027 110510964
Radiation inflammation 49.68 11.49 18 45290 1030 110542961
Macular degeneration 48.84 11.49 52 45256 21607 110522384
Taste disorder 47.12 11.49 91 45217 65296 110478695
Pulmonary toxicity 46.15 11.49 46 45262 17700 110526291
Product dose omission issue 42.61 11.49 251 45057 321531 110222460
Joint injury 40.98 11.49 65 45243 39929 110504062
Salpingo-oophorectomy unilateral 38.37 11.49 14 45294 817 110543174
Paraesthesia oral 37.68 11.49 57 45251 33614 110510377
Adverse reaction 37.32 11.49 53 45255 29541 110514450
Coma 36.98 11.49 3 45305 117866 110426125
Death 36.39 11.49 155 45153 698714 109845277
Neutropenia 35.37 11.49 62 45246 374558 110169433
Necrosis ischaemic 34.96 11.49 15 45293 1344 110542647
Intentional overdose 32.97 11.49 7 45301 132494 110411497
Joint stiffness 32.86 11.49 80 45228 67163 110476828
Thrombocytopenia 32.70 11.49 58 45250 348827 110195164
Vaginal flatulence 32.54 11.49 32 45276 12112 110531879
Obesity 32.21 11.49 111 45197 113240 110430751
Neoplasm malignant 32.20 11.49 56 45252 37087 110506904
Procedural pain 31.33 11.49 54 45254 35511 110508480
Carbuncle 30.68 11.49 14 45294 1453 110542538
Illness 30.26 11.49 88 45220 82083 110461908
Aplastic anaemia 29.87 11.49 43 45265 24265 110519726
Onychomadesis 29.83 11.49 61 45247 45602 110498389
Nail disorder 29.47 11.49 70 45238 57865 110486126
Skin odour abnormal 29.28 11.49 16 45292 2438 110541553
Cardiac failure 28.66 11.49 21 45287 187605 110356386
Drug interaction 28.50 11.49 107 45201 500076 110043915
Off label use 28.07 11.49 808 44500 1499377 109044614
Arthropathy 27.58 11.49 207 45101 287315 110256676
Rheumatoid factor positive 27.10 11.49 10 45298 131630 110412361
Monoclonal immunoglobulin present 26.07 11.49 15 45293 2525 110541466
Back injury 26.00 11.49 59 45249 47340 110496651
Neck pain 25.46 11.49 109 45199 123021 110420970
Nasal polyps 25.12 11.49 29 45279 13171 110530820
Sinusitis fungal 25.11 11.49 15 45293 2705 110541286
Genital pain 25.06 11.49 12 45296 1388 110542603
Lower respiratory tract infection 25.02 11.49 178 45130 242928 110301063
Radiculopathy 24.93 11.49 35 45273 19301 110524690
Osteoarthritis 24.50 11.49 143 45165 182480 110361511
Hypothalamo-pituitary disorder 24.49 11.49 15 45293 2831 110541160
Dermatitis atopic 24.11 11.49 40 45268 25501 110518490
Pneumonia streptococcal 24.08 11.49 16 45292 3473 110540518
Vaginal discharge 23.96 11.49 33 45275 17875 110526116
Beta haemolytic streptococcal infection 23.89 11.49 15 45293 2956 110541035
Proctitis 23.88 11.49 32 45276 16895 110527096
Myelosuppression 23.44 11.49 5 45303 94335 110449656
Hyponatraemia 23.40 11.49 33 45275 217620 110326371
Angioedema 22.93 11.49 6 45302 98494 110445497
Sinus pain 22.65 11.49 19 45289 5860 110538131
Agitation 22.59 11.49 9 45299 113042 110430949
Tenderness 22.48 11.49 42 45266 29395 110514596
Blepharospasm 22.40 11.49 61 45247 54790 110489201
Hypokalaemia 22.39 11.49 25 45283 182423 110361568
Migraine 22.12 11.49 133 45175 171519 110372472
Sleep disorder due to general medical condition, insomnia type 21.79 11.49 8 45300 105635 110438356
Oral candidiasis 21.60 11.49 53 45255 44707 110499284
Acquired diaphragmatic eventration 21.34 11.49 9 45299 773 110543218
Oral pain 20.98 11.49 47 45261 37397 110506594
Disease progression 20.73 11.49 43 45265 243991 110300000
Dyspepsia 20.33 11.49 141 45167 190824 110353167
Wound secretion 20.03 11.49 19 45289 6882 110537109
Drug ineffective 19.95 11.49 473 44835 1520067 109023924
Leukopenia 19.83 11.49 19 45289 148772 110395219
Electrocardiogram QT prolonged 19.69 11.49 10 45298 108950 110435041
Memory impairment 19.56 11.49 143 45165 196801 110347190
Breast cancer stage III 19.52 11.49 74 45234 79043 110464948
Infrapatellar fat pad inflammation 18.99 11.49 6 45302 225 110543766
Embolism venous 18.87 11.49 16 45292 5007 110538984
Myocardial infarction 18.84 11.49 31 45277 192052 110351939
Coeliac disease 18.62 11.49 49 45259 43138 110500853
Lipoedema 18.55 11.49 6 45302 243 110543748
Genital ulceration 18.52 11.49 11 45297 1964 110542027
Wrist deformity 18.18 11.49 13 45295 3176 110540815
Muscle spasms 18.17 11.49 184 45124 277973 110266018
Suicide attempt 17.94 11.49 10 45298 103384 110440607
Overdose 17.92 11.49 160 45148 233634 110310357
Incorrect product administration duration 17.89 11.49 31 45277 20467 110523524
Bone density decreased 17.73 11.49 27 45281 16015 110527976
Lactic acidosis 17.56 11.49 8 45300 92803 110451188
Abdominal distension 17.31 11.49 127 45181 174976 110369015
Drug reaction with eosinophilia and systemic symptoms 17.30 11.49 6 45302 82089 110461902
Sputum increased 17.01 11.49 16 45292 5735 110538256
Heart rate variability increased 16.96 11.49 4 45304 48 110543943
Gastrointestinal haemorrhage 16.91 11.49 26 45282 165492 110378499
Tachycardia 16.78 11.49 43 45265 226602 110317389
Red blood cell sedimentation rate decreased 16.76 11.49 9 45299 1325 110542666
Feeling abnormal 16.70 11.49 129 45179 180582 110363409
Vertebral lateral recess stenosis 16.51 11.49 6 45302 346 110543645
Liver function test increased 16.50 11.49 76 45232 88472 110455519
Cardio-respiratory arrest 16.38 11.49 14 45294 115822 110428169
Hyperkalaemia 16.24 11.49 19 45289 135777 110408214
Knee arthroplasty 16.23 11.49 61 45247 64887 110479104
Hepatic enzyme decreased 16.17 11.49 8 45300 994 110542997
Ligamentum flavum hypertrophy 16.14 11.49 6 45302 369 110543622
Osteoarthropathy 16.08 11.49 6 45302 373 110543618
Pneumonia 15.93 11.49 258 45050 876456 109667535
Hypotension 15.86 11.49 302 45006 523547 110020444
Hysterectomy 15.73 11.49 18 45290 8096 110535895
Product quality issue 15.65 11.49 68 45240 77231 110466760
Bladder disorder 15.62 11.49 21 45287 11116 110532875
Food poisoning 15.62 11.49 16 45292 6356 110537635
Peripheral venous disease 15.53 11.49 72 45236 84045 110459946
Malignant neoplasm progression 15.48 11.49 30 45278 174537 110369454
Allergy to chemicals 15.47 11.49 12 45296 3313 110540678
Synovial fluid analysis 15.44 11.49 11 45297 2670 110541321
Overweight 15.43 11.49 16 45292 6448 110537543
Respiratory failure 15.07 11.49 42 45266 215290 110328701
Toxic anterior segment syndrome 15.07 11.49 12 45296 3442 110540549
Fistula discharge 15.00 11.49 9 45299 1637 110542354
Injection site pain 14.80 11.49 124 45184 177798 110366193
Tenosynovitis stenosans 14.62 11.49 12 45296 3591 110540400
Eosinophilia 14.54 11.49 3 45305 57933 110486058
Limb injury 14.52 11.49 41 45267 37595 110506396
Synovial disorder 14.32 11.49 11 45297 2996 110540995
Gastrooesophageal reflux disease 14.22 11.49 124 45184 179852 110364139
Metabolic acidosis 14.17 11.49 12 45296 99732 110444259
Hypoglycaemia 14.15 11.49 16 45292 116088 110427903
Scar 14.05 11.49 25 45283 16856 110527135
Gastrointestinal candidiasis 14.02 11.49 6 45302 534 110543457
Drug resistance 13.98 11.49 3 45305 56371 110487620
C-reactive protein abnormal 13.94 11.49 96 45212 129599 110414392
Endometrial cancer 13.90 11.49 10 45298 2466 110541525
Wound infection 13.89 11.49 77 45231 96388 110447603
Sepsis 13.87 11.49 78 45230 327268 110216723
Gamma-glutamyltransferase increased 13.77 11.49 4 45304 61305 110482686
Genital herpes 13.64 11.49 10 45298 2537 110541454
Body height decreased 13.44 11.49 19 45289 10544 110533447
Urinary tract discomfort 13.41 11.49 7 45301 973 110543018
Musculoskeletal pain 13.38 11.49 124 45184 182899 110361092
Fibrosis 13.23 11.49 16 45292 7626 110536365
Febrile neutropenia 13.14 11.49 76 45232 316691 110227300
Blood testosterone abnormal 13.09 11.49 5 45303 332 110543659
Oedema peripheral 13.03 11.49 80 45228 328580 110215411
Haematemesis 13.02 11.49 4 45304 59104 110484887
Renal impairment 13.01 11.49 37 45271 188408 110355583
Pyrexia 12.99 11.49 275 45033 897990 109646001
Osmophobia 12.95 11.49 4 45304 139 110543852
Effusion 12.94 11.49 10 45298 2747 110541244
Normal newborn 12.85 11.49 28 45280 21868 110522123
Blood creatine phosphokinase increased 12.77 11.49 7 45301 73070 110470921
Inflammation 12.69 11.49 128 45180 193110 110350881
Chronic inflammatory demyelinating polyradiculoneuropathy 12.63 11.49 9 45299 2186 110541805
Spinal cord disorder 12.62 11.49 9 45299 2189 110541802
Vomiting 12.53 11.49 281 45027 910394 109633597
Chondropathy 12.53 11.49 10 45298 2877 110541114
Atrial fibrillation 12.50 11.49 50 45258 229592 110314399
Sneezing 12.50 11.49 35 45273 31949 110512042
Cardiac failure congestive 12.49 11.49 27 45281 150973 110393018
Lack of infusion site rotation 12.46 11.49 4 45304 158 110543833
Musculoskeletal stiffness 12.46 11.49 172 45136 279650 110264341
Hepato-lenticular degeneration 12.43 11.49 3 45305 40 110543951
Hyperglycaemia 12.38 11.49 10 45298 85080 110458911
Blood bilirubin increased 12.26 11.49 8 45300 75964 110468027
Calcitonin secretion disorder 12.23 11.49 3 45305 43 110543948
Underdose 12.18 11.49 55 45253 63499 110480492
Arthritis infective 12.16 11.49 18 45290 10411 110533580
Acute myocardial infarction 12.00 11.49 10 45298 83767 110460224
Cytokine release syndrome 11.91 11.49 7 45301 70299 110473692
Therapeutic product effect incomplete 11.83 11.49 142 45166 223663 110320328
Intentional product misuse 11.79 11.49 94 45214 132810 110411181
Dry skin 11.76 11.49 80 45228 107573 110436418
Dementia 11.73 11.49 34 45274 31639 110512352
Appetite disorder 11.59 11.49 17 45291 9752 110534239
Product use in unapproved indication 11.57 11.49 252 45056 447125 110096866
Hepatotoxicity 11.50 11.49 54 45254 63346 110480645

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05XA12 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions
MeSH PA D009067 Mouthwashes
CHEBI has role CHEBI:39143 Lewis acid
CHEBI has role CHEBI:48219 disinfectant
CHEBI has role CHEBI:74783 astringent
CHEBI has role CHEBI:86385 EC 5.3.3.5 (cholestenol Δ-isomerase) inhibitor

Related Drugs by ATC class:

B05XA Electrolyte solutions 18 drugs
ammonium chloridecalcium chloridecalcium gluconatehydrochloric acidmagnesium chloridemagnesium phosphatemagnesium sulfatepotassium acetatepotassium chloridepotassium lactatepotassium phosphatesodium acetate show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Zinc deficiency indication 238124008
Local anesthesia indication 386761002
Mouth Irritation indication
Suppression of the Gag Reflex indication
Hereditary acrodermatitis enteropathica off-label use 37702000
Cerebral trauma off-label use 275382005
Hypocupremia contraindication 19577007
Methemoglobinemia contraindication 38959009 DOID:10783
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
G-protein coupled receptor 39 GPCR EC50 8.44 CHEMBL
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme IC50 5.96 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.16 DRUG MATRIX
Carbonic anhydrase 2 Enzyme IC50 5.94 DRUG MATRIX
Epidermal growth factor receptor Kinase IC50 5.66 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.73 DRUG MATRIX
Ubiquitin-conjugating enzyme E2 T Enzyme Kd 4.80 CHEMBL
G protein-coupled receptor 39-1b GPCR EC50 5.39 CHEMBL
Androgen receptor Transcription factor Ki 5.36 DRUG MATRIX

External reference:

IDSource
4018532 VUID
N0000146854 NUI
D02058 KEGG_DRUG
4018532 VANDF
C0078774 UMLSCUI
CHEBI:49976 CHEBI
CHEMBL1200679 ChEMBL_ID
DB14533 DRUGBANK_ID
C016837 MESH_SUPPLEMENTAL_RECORD_UI
86Q357L16B UNII
5727 PUBCHEM_CID
39937 RXNORM
1505 MMSL
5707 MMSL
d04055 MMSL
000842 NDDF
001942 NDDF
86Q357L16B INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 0363-0607 CREAM 0.15 g ORAL OTC Monograph Drug 10 sections
3x Medicated Mouth Sore Gel HUMAN OTC DRUG LABEL 3 0363-1605 GEL 0.15 g ORAL OTC Monograph Drug 7 sections
PM Toothache Relief HUMAN OTC DRUG LABEL 4 0363-1623 PASTE 0.15 g DENTAL OTC Monograph Drug 8 sections
4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 0363-6008 GEL 0.15 g ORAL OTC Monograph Drug 9 sections
ZINC HUMAN PRESCRIPTION DRUG LABEL 1 0409-4090 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
KANKA SoftBrush HUMAN OTC DRUG LABEL 2 10157-2106 GEL 0.10 g ORAL OTC monograph drug 12 sections
Orajel Rescue Relief Pen HUMAN OTC DRUG LABEL 3 10237-731 GEL 1.50 mg ORAL OTC Monograph Drug 12 sections
Orajel Toothache Rinse HUMAN OTC DRUG LABEL 2 10237-764 LIQUID 1.50 mg TOPICAL OTC Monograph Drug 11 sections
Orajel 3X Medicated For All Mouth Sores HUMAN OTC DRUG LABEL 3 10237-783 GEL 1.50 mg TOPICAL OTC Monograph Drug 12 sections
Orajel 4X Medicated For Toothache and Gum HUMAN OTC DRUG LABEL 4 10237-787 GEL 1.50 mg TOPICAL OTC Monograph Drug 12 sections
Orajel 4X Medicated PM For Toothache and Gum HUMAN OTC DRUG LABEL 4 10237-789 CREAM 1.50 mg TOPICAL OTC Monograph Drug 12 sections
Orajel 3X Medicated For Toothache and Gum HUMAN OTC DRUG LABEL 3 10237-790 GEL 1.50 mg TOPICAL OTC Monograph Drug 12 sections
Orajel Gum Pain 3X Medicated HUMAN OTC DRUG LABEL 3 10237-792 GEL 1.50 mg TOPICAL OTC MONOGRAPH DRUG 12 sections
Rite AidMaximum Strength HUMAN OTC DRUG LABEL 3 11822-0317 GEL, DENTIFRICE 0.10 g ORAL OTC monograph not final 9 sections
3X Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 3 11822-0613 GEL 0.15 g ORAL OTC Monograph Drug 11 sections
4X Medicated Severe Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 11822-0614 CREAM 0.15 g ORAL OTC Monograph Drug 10 sections
4X Medicated Severe Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 11822-0615 GEL 0.15 g ORAL OTC Monograph Drug 10 sections
3X Medicated Mouth Sore Gel HUMAN OTC DRUG LABEL 3 11822-6170 GEL 0.15 g ORAL OTC Monograph Drug 8 sections
Nighttime 4X Medicated Cream HUMAN OTC DRUG LABEL 4 11822-6300 PASTE 0.15 g ORAL OTC Monograph Drug 10 sections
4x Medicated Gum Cream HUMAN OTC DRUG LABEL 4 21130-621 CREAM 0.15 g ORAL OTC Monograph Drug 9 sections
KDS LabLiquid Styptic HUMAN OTC DRUG LABEL 3 24488-040 LIQUID 400.02 mg TOPICAL OTC monograph not final 13 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 30142-212 CREAM 0.15 g ORAL OTC Monograph Drug 9 sections
Severe Triple Medicated Gel HUMAN OTC DRUG LABEL 3 36800-389 GEL 0.15 g ORAL OTC monograph not final 9 sections
Topco 4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 36800-624 GEL 0.15 g ORAL OTC Monograph Drug 9 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 37808-116 CREAM 0.15 g ORAL OTC Monograph Drug 10 sections
HEB Mouth Sore Relief HUMAN OTC DRUG LABEL 3 37808-312 GEL 0.10 g TOPICAL OTC monograph not final 12 sections
3x Medicated Mouth Sore Gel HUMAN OTC DRUG LABEL 3 37808-691 GEL 0.15 g ORAL OTC Monograph Drug 12 sections
G-BUCAL-C HUMAN OTC DRUG LABEL 2 43913-402 SPRAY 30 mg OROPHARYNGEAL OTC MONOGRAPH NOT FINAL 9 sections
4X Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 49035-569 GEL 0.15 g ORAL OTC Monograph Drug 11 sections
Zinc Chloride HUMAN PRESCRIPTION DRUG LABEL 1 51754-0102 INJECTION 1 mg INTRAVENOUS ANDA 20 sections