doconexent 🐢 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4289 6217-54-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • docosahexaenoic acid
  • doconexent
  • cervonic acid
  • efalex
a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement
  • Molecular weight: 328.50
  • Formula: C22H32O2
  • CLOGP: 7.48
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -6.25
  • ROTB: 14

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 198.88 43.50 61 1395 30943 50572725
Coma 162.58 43.50 61 1395 56818 50546850
Gastrooesophageal reflux disease 145.10 43.50 61 1395 76367 50527301
Somnolence 112.19 43.50 64 1392 154921 50448747
Muscle spasticity 65.99 43.50 23 1433 17161 50586507
Respiratory disorder 62.64 43.50 26 1430 31161 50572507
Body temperature increased 55.84 43.50 24 1432 31317 50572351
Ear pain 54.84 43.50 23 1433 28260 50575408
Night sweats 51.05 43.50 23 1433 33551 50570117

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 108.44 43.39 42 1287 59229 64438174
Gastrooesophageal reflux disease 94.70 43.39 42 1287 83101 64414302
Coma 92.59 43.39 42 1287 87573 64409830
Somnolence 69.01 43.39 46 1283 203599 64293804
Child abuse 59.38 43.39 9 1320 211 64497192
Muscle spasticity 53.72 43.39 18 1311 16651 64480752
Victim of child abuse 53.29 43.39 10 1319 861 64496542
Epidural lipomatosis 46.95 43.39 9 1320 868 64496535
Ear pain 46.50 43.39 18 1311 25118 64472285

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:83146 Daphnia tenebrosa metabolites
CHEBI has role CHEBI:84735 algal metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use




🐢 Veterinary Drug Use

None

🐢 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aromatase Enzyme IC50 4.48 CHEMBL
Retinoic acid receptor RXR-alpha Nuclear hormone receptor Ki 5.20 CHEMBL
Free fatty acid receptor 1 GPCR AGONIST EC50 6 IUPHAR
Oxoeicosanoid receptor 1 GPCR IC50 5.70 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.01 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.82 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Ion channel ACTIVATOR EC50 4.40 IUPHAR

External reference:

IDSource
4020132 VUID
N0000148111 NUI
4020132 VANDF
C2348308 UMLSCUI
CHEBI:28125 CHEBI
F22 PDB_CHEM_ID
HXA PDB_CHEM_ID
CHEMBL367149 ChEMBL_ID
DB03756 DRUGBANK_ID
C532150 MESH_SUPPLEMENTAL_RECORD_UI
1051 IUPHAR_LIGAND_ID
6428 INN_ID
ZAD9OKH9JC UNII
445580 PUBCHEM_CID
1006469 RXNORM
002051 NDDF
226368001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 260 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 260 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 250 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 250 mg ORAL Unapproved drug other 11 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 200 mg ORAL unapproved drug other 10 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 200 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 200 mg ORAL UNAPPROVED DRUG OTHER 14 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 200 mg ORAL UNAPPROVED DRUG OTHER 12 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 10 42192-321 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 11 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 8 42192-323 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 11 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 12 sections
Prenaissance HUMAN PRESCRIPTION DRUG LABEL 9 42192-341 CAPSULE, LIQUID FILLED 325 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Prenaissance Plus HUMAN PRESCRIPTION DRUG LABEL 8 42192-343 CAPSULE, LIQUID FILLED 250 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Animi-3 with Vitamin D HUMAN PRESCRIPTION DRUG LABEL 8 66213-542 CAPSULE 250 mg ORAL unapproved drug other 14 sections
Animi-3 HUMAN PRESCRIPTION DRUG LABEL 8 66213-543 CAPSULE 250 mg ORAL unapproved drug other 14 sections
TRICARE PRENATAL DHA ONE HUMAN PRESCRIPTION DRUG LABEL 17 67112-401 CAPSULE, GELATIN COATED 215 mg ORAL unapproved drug other 12 sections
PRENATE Restore HUMAN PRESCRIPTION DRUG LABEL 12 75854-308 CAPSULE, GELATIN COATED 400 mg ORAL unapproved drug other 13 sections
PRENATE Enhance HUMAN PRESCRIPTION DRUG LABEL 12 75854-309 CAPSULE, GELATIN COATED 400 mg ORAL unapproved drug other 13 sections
PRENATE DHA HUMAN PRESCRIPTION DRUG LABEL 10 75854-312 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 13 sections
Prenate Essential HUMAN PRESCRIPTION DRUG LABEL 14 75854-313 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 13 sections
Prenate Mini HUMAN PRESCRIPTION DRUG LABEL 15 75854-315 CAPSULE, GELATIN COATED 350 mg ORAL unapproved drug other 12 sections