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doconexent 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4289	6217-54-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: docosahexaenoic acid doconexent cervonic acid efalex	a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement Molecular weight: 328.50 Formula: C22H32O2 CLOGP: 7.48 LIPINSKI: 1 HAC: 2 HDO: 1 TPSA: 37.30 ALOGS: -6.25 ROTB: 14

Molecule

Description

Molfile Inchi Smiles

Synonyms:

docosahexaenoic acid
doconexent
cervonic acid
efalex

a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement

Molecular weight: 328.50
Formula: C22H32O2
CLOGP: 7.48
LIPINSKI: 1
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -6.25
ROTB: 14

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	177.13	38.35	65	2757	32346	56256899
Coma	138.81	38.35	65	2757	59590	56229655
Gastrooesophageal reflux disease	118.30	38.35	65	2757	83192	56206053
Somnolence	86.89	38.35	69	2753	163344	56125901
Muscle spasticity	80.06	38.35	32	2790	19928	56269317
Respiratory disorder	72.72	38.35	35	2787	33922	56255323
Ear pain	66.62	38.35	32	2790	30858	56258387
Body temperature increased	66.44	38.35	33	2789	34209	56255036
Incorrect route of product administration	58.15	38.35	26	2796	21303	56267942
Night sweats	57.91	38.35	32	2790	41181	56248064
Underdose	43.43	38.35	22	2800	23735	56265510
Sinusitis	41.14	38.35	50	2772	197531	56091714
Rheumatic disorder	38.92	38.35	11	2811	2365	56286880

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	93.82	42.49	46	2612	62243	70863543
Gastrooesophageal reflux disease	77.52	42.49	46	2612	90793	70834993
Coma	77.05	42.49	46	2612	91798	70833988
Muscle spasticity	67.47	42.49	26	2632	19663	70906123
Incorrect route of product administration	60.01	42.49	26	2632	26466	70899320
Ear pain	58.99	42.49	26	2632	27573	70898213
Somnolence	53.26	42.49	52	2606	215554	70710232
Body temperature increased	52.79	42.49	27	2631	39807	70885979
Respiratory disorder	50.34	42.49	26	2632	39097	70886689
Child abuse	49.24	42.49	9	2649	364	70925422
Night sweats	47.65	42.49	26	2632	43658	70882128
Victim of child abuse	46.56	42.49	10	2648	928	70924858
Underdose	45.07	42.49	22	2636	29361	70896425

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:83146	Daphnia tenebrosa metabolites
CHEBI has role	CHEBI:84735	algal metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID
Pregnancy, function	indication	289908002
Breastfeeding (mother)	indication	413712001
Prevention of Fetal Neural Tube Defects during Pregnancy	off-label use

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.37	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Free fatty acid receptor 1	GPCR	O14842	FFAR1_HUMAN	AGONIST	EC50	6	IUPHAR
Aromatase	Enzyme	P11511	CP19A_HUMAN		IC50	4.48	CHEMBL
Retinoic acid receptor RXR-alpha	Nuclear hormone receptor	P19793	RXRA_HUMAN		Ki	5.20	CHEMBL
Oxoeicosanoid receptor 1	GPCR	Q8TDS5	OXER1_HUMAN		IC50	5.70	CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_SHEEP		IC50	5.01	CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_BOVIN		IC50	4.82	CHEMBL
Transient receptor potential cation channel subfamily A member 1	Ion channel		TRPA1_RAT	ACTIVATOR	EC50	4.40	IUPHAR

External reference:

ID	Source
4020132	VUID
N0000148111	NUI
4020132	VANDF
C2348308	UMLSCUI
CHEBI:28125	CHEBI
F22	PDB_CHEM_ID
HXA	PDB_CHEM_ID
CHEMBL367149	ChEMBL_ID
DB03756	DRUGBANK_ID
C532150	MESH_SUPPLEMENTAL_RECORD_UI
1051	IUPHAR_LIGAND_ID
6428	INN_ID
ZAD9OKH9JC	UNII
445580	PUBCHEM_CID
1006469	RXNORM
002051	NDDF
226368001	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	260 mg	ORAL	unapproved drug other	10 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	260 mg	ORAL	unapproved drug other	10 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0798	CAPSULE, GELATIN COATED	260 mg	ORAL	UNAPPROVED DRUG OTHER	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0799	CAPSULE, GELATIN COATED	250 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0812	CAPSULE, GELATIN COATED	250 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	200 mg	ORAL	unapproved drug other	10 sections
Vitafol Ultra	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0093	CAPSULE, LIQUID FILLED	200 mg	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol Fe Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-7473	CAPSULE, LIQUID FILLED	200 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
TriStart DHA	HUMAN PRESCRIPTION DRUG LABEL	15	15370-250	CAPSULE, LIQUID FILLED	200 mg	ORAL	UNAPPROVED DRUG OTHER	12 sections
PNV-DHA	HUMAN PRESCRIPTION DRUG LABEL	10	42192-321	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	11 sections
PNV-DHA	HUMAN PRESCRIPTION DRUG LABEL	8	42192-323	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	11 sections
PNV-Omega	HUMAN PRESCRIPTION DRUG LABEL	13	42192-332	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	12 sections
Prenaissance	HUMAN PRESCRIPTION DRUG LABEL	9	42192-341	CAPSULE, LIQUID FILLED	325 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
Prenaissance Plus	HUMAN PRESCRIPTION DRUG LABEL	8	42192-343	CAPSULE, LIQUID FILLED	250 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
Animi-3 with Vitamin D	HUMAN PRESCRIPTION DRUG LABEL	8	66213-542	CAPSULE	250 mg	ORAL	unapproved drug other	14 sections
Animi-3	HUMAN PRESCRIPTION DRUG LABEL	8	66213-543	CAPSULE	250 mg	ORAL	unapproved drug other	14 sections
TRICARE PRENATAL DHA ONE	HUMAN PRESCRIPTION DRUG LABEL	17	67112-401	CAPSULE, GELATIN COATED	215 mg	ORAL	unapproved drug other	12 sections
PRENATE Restore	HUMAN PRESCRIPTION DRUG LABEL	12	75854-308	CAPSULE, GELATIN COATED	400 mg	ORAL	unapproved drug other	13 sections
PRENATE Enhance	HUMAN PRESCRIPTION DRUG LABEL	12	75854-309	CAPSULE, GELATIN COATED	400 mg	ORAL	unapproved drug other	13 sections
PRENATE DHA	HUMAN PRESCRIPTION DRUG LABEL	10	75854-312	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	13 sections
Prenate Essential	HUMAN PRESCRIPTION DRUG LABEL	14	75854-313	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	13 sections
Prenate Mini	HUMAN PRESCRIPTION DRUG LABEL	15	75854-315	CAPSULE, GELATIN COATED	350 mg	ORAL	unapproved drug other	12 sections