doconexent Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4289 6217-54-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • docosahexaenoic acid
  • doconexent
  • cervonic acid
  • efalex
a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement
  • Molecular weight: 328.50
  • Formula: C22H32O2
  • CLOGP: 7.48
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -6.25
  • ROTB: 14

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 152.19 32.83 65 3491 31540 46650966
Coma 114.34 32.83 65 3491 58284 46624222
Gastrooesophageal reflux disease 104.74 32.83 67 3489 74277 46608229
Pleural thickening 72.59 32.83 20 3536 2575 46679931
Somnolence 71.73 32.83 73 3483 156448 46526058
Blood magnesium increased 69.55 32.83 20 3536 3007 46679499
Presbyacusis 66.42 32.83 19 3537 2803 46679703
Pleural fibrosis 66.29 32.83 20 3536 3549 46678957
Deafness neurosensory 61.75 32.83 20 3536 4474 46678032
Laryngitis 61.29 32.83 24 3532 9292 46673214
Epigastric discomfort 57.15 32.83 20 3536 5664 46676842
Muscle spasticity 53.22 32.83 23 3533 11417 46671089
Immunodeficiency 50.22 32.83 23 3533 13083 46669423
Respiratory disorder 46.98 32.83 28 3528 27272 46655234
Cyst 45.63 32.83 21 3535 12079 46670427
Joint swelling 41.74 32.83 57 3499 166016 46516490
Ear pain 41.54 32.83 24 3532 22068 46660438
Bone cyst 40.27 32.83 12 3544 2039 46680467
Osteopenia 38.90 32.83 21 3535 16940 46665566
Blood potassium increased 38.90 32.83 21 3535 16946 46665560
Body temperature increased 36.39 32.83 23 3533 24838 46657668
Night sweats 34.46 32.83 23 3533 27227 46655279
Osteosclerosis 33.92 32.83 12 3544 3504 46679002

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coronary artery disease 38.72 31.02 17 393 49695 29902373

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:50733 nutritional supplement
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:77746 h. sapiens metabolites
CHEBI has role CHEBI:83146 daphnia tenebrosa metabolites
CHEBI has role CHEBI:84735 algal metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Free fatty acid receptor 1 GPCR AGONIST EC50 6 IUPHAR
Aromatase Enzyme IC50 4.48 CHEMBL
Oxoeicosanoid receptor 1 GPCR IC50 5.70 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.01 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.82 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Unclassified ACTIVATOR EC50 4.40 IUPHAR

External reference:

IDSource
4020132 VUID
N0000148111 NUI
4020132 VANDF
C2348308 UMLSCUI
CHEBI:28125 CHEBI
F22 PDB_CHEM_ID
HXA PDB_CHEM_ID
CHEMBL367149 ChEMBL_ID
DB03756 DRUGBANK_ID
C532150 MESH_SUPPLEMENTAL_RECORD_UI
445580 PUBCHEM_CID
1051 IUPHAR_LIGAND_ID
6428 INN_ID
ZAD9OKH9JC UNII
1006469 RXNORM
002051 NDDF
226368001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 260 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 260 mg ORAL UNULLPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 250 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 250 mg ORAL Unapproved drug other 11 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 200 mg ORAL unapproved drug other 10 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 200 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 200 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 200 mg ORAL UNULLPPROVED DRUG OTHER 12 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 10 42192-321 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 11 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 8 42192-323 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 11 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 12 sections
Prenaissance HUMAN PRESCRIPTION DRUG LABEL 9 42192-341 CAPSULE, LIQUID FILLED 325 mg ORAL UNULLPPROVED DRUG OTHER 10 sections
Prenaissance Plus HUMAN PRESCRIPTION DRUG LABEL 8 42192-343 CAPSULE, LIQUID FILLED 250 mg ORAL UNULLPPROVED DRUG OTHER 10 sections
Animi-3 with Vitamin D HUMAN PRESCRIPTION DRUG LABEL 8 66213-542 CAPSULE 250 mg ORAL unapproved drug other 14 sections
Animi-3 HUMAN PRESCRIPTION DRUG LABEL 8 66213-543 CAPSULE 250 mg ORAL unapproved drug other 14 sections
TRICARE PRENULLTAL DHA ONE HUMAN PRESCRIPTION DRUG LABEL 17 67112-401 CAPSULE, GELATIN COATED 215 mg ORAL unapproved drug other 12 sections
TRICARE PRENULLTAL DHA ONE HUMAN PRESCRIPTION DRUG LABEL 17 67112-401 CAPSULE, GELATIN COATED 215 mg ORAL unapproved drug other 12 sections
TRICARE PRENULLTAL DHA ONE RXMULTIVITAMIN HUMAN PRESCRIPTION DRUG LABEL 18 67112-402 CAPSULE, GELATIN COATED 215 mg ORAL unapproved drug other 11 sections
PRENULLTE Restore HUMAN PRESCRIPTION DRUG LABEL 12 75854-308 CAPSULE, GELATIN COATED 400 mg ORAL unapproved drug other 13 sections
PRENULLTE Enhance HUMAN PRESCRIPTION DRUG LABEL 12 75854-309 CAPSULE, GELATIN COATED 400 mg ORAL unapproved drug other 13 sections
PRENULLTE DHA HUMAN PRESCRIPTION DRUG LABEL 10 75854-312 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 13 sections
Prenate Essential HUMAN PRESCRIPTION DRUG LABEL 14 75854-313 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 13 sections
Prenate Mini HUMAN PRESCRIPTION DRUG LABEL 15 75854-315 CAPSULE, GELATIN COATED 350 mg ORAL unapproved drug other 12 sections