doconexent Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4289 6217-54-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • docosahexaenoic acid
  • doconexent
  • cervonic acid
  • efalex
a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement
  • Molecular weight: 328.50
  • Formula: C22H32O2
  • CLOGP: 7.48
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -6.25
  • ROTB: 14

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:50733 nutraceutical
CHEBI has role CHEBI:35610 antineoplastic agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Free fatty acid receptor 1 GPCR AGONIST EC50 6 IUPHAR
Aromatase Enzyme IC50 4.48 CHEMBL
Oxoeicosanoid receptor 1 GPCR IC50 5.70 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.01 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.82 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Unclassified ACTIVATOR EC50 4.40 IUPHAR

External reference:

IDSource
4020132 VUID
N0000148111 NUI
C0556150 UMLSCUI
1006469 RXNORM
CHEMBL367149 ChEMBL_ID
C532150 MESH_SUPPLEMENTAL_RECORD_UI
DB03756 DRUGBANK_ID
CHEBI:28125 CHEBI
ZAD9OKH9JC UNII
6428 INN_ID
1051 IUPHAR_LIGAND_ID
445580 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 7 0178-0796 CAPSULE, GELATIN COATED 260 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 260 mg ORAL UNAPPROVED DRUG OTHER 12 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 250 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 250 mg ORAL Unapproved drug other 11 sections
CitraNatal Assure HUMAN PRESCRIPTION DRUG LABEL 13 0178-0891 KIT 300 mg None unapproved drug other 12 sections
CitraNatal Assure HUMAN PRESCRIPTION DRUG LABEL 14 0178-0893 KIT 300 mg None Unapproved drug other 12 sections
CitraNatal DHA HUMAN PRESCRIPTION DRUG LABEL 14 0178-0894 KIT 250 mg None unapproved drug other 11 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 7 0178-0896 CAPSULE, GELATIN COATED 200 mg ORAL unapproved drug other 9 sections
Select-OB Plus DHA HUMAN PRESCRIPTION DRUG LABEL 15 0642-0075 KIT 250 mg None Unapproved drug other 10 sections
Vitafol-OB Plus DHA HUMAN PRESCRIPTION DRUG LABEL 10 0642-0076 KIT 250 mg None Unapproved drug other 13 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 16 0642-0093 CAPSULE, LIQUID FILLED 200 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 12 0642-0096 KIT 200 mg None UNAPPROVED DRUG OTHER 10 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 16 0642-7473 CAPSULE, LIQUID FILLED 200 mg ORAL UNAPPROVED DRUG OTHER 10 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 200 mg ORAL UNAPPROVED DRUG OTHER 11 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 8 42192-321 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 9 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 7 42192-323 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 9 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 300 mg ORAL unapproved drug other 9 sections
Prenaissance HUMAN PRESCRIPTION DRUG LABEL 9 42192-341 CAPSULE, LIQUID FILLED 325 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Prenaissance Plus HUMAN PRESCRIPTION DRUG LABEL 7 42192-343 CAPSULE, LIQUID FILLED 250 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Pre-Tabs DHA HUMAN PRESCRIPTION DRUG LABEL 16 48948-406 KIT 230 mg None unapproved drug other 10 sections
NESTABS DHA HUMAN PRESCRIPTION DRUG LABEL 15 50967-317 KIT 230 mg None unapproved drug other 9 sections
Prenatal, DHA HUMAN PRESCRIPTION DRUG LABEL 14 59088-096 KIT 250 mg None Unapproved drug other 10 sections
Animi-3 with Vitamin D HUMAN PRESCRIPTION DRUG LABEL 6 66213-542 CAPSULE 250 mg ORAL unapproved drug other 14 sections
Animi-3 HUMAN PRESCRIPTION DRUG LABEL 6 66213-543 CAPSULE 250 mg ORAL unapproved drug other 14 sections
TRICARE PRENATAL DHA ONE HUMAN PRESCRIPTION DRUG LABEL 15 67112-401 CAPSULE, GELATIN COATED 215 mg ORAL unapproved drug other 12 sections
TRICARE PRENATAL DHA ONE RX HUMAN PRESCRIPTION DRUG LABEL 15 67112-402 CAPSULE, GELATIN COATED 215 mg ORAL unapproved drug other 10 sections
TRICARE PRENATAL COMPLEAT HUMAN PRESCRIPTION DRUG LABEL 13 67112-501 KIT 135 mg None unapproved drug other 2 sections
TRICARE PRENATAL 2-PART DAILY PRENATAL VITAMIN SYSTEM HUMAN PRESCRIPTION DRUG LABEL 12 67112-502 KIT 150 1 None unapproved drug other 1 sections
PRENATE Restore HUMAN PRESCRIPTION DRUG LABEL 12 75854-308 CAPSULE, GELATIN COATED 400 mg ORAL unapproved drug other 13 sections
PRENATE Enhance HUMAN PRESCRIPTION DRUG LABEL 12 75854-309 CAPSULE, GELATIN COATED 400 mg ORAL unapproved drug other 13 sections