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doconexent 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4289	6217-54-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: docosahexaenoic acid doconexent cervonic acid efalex	a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement Molecular weight: 328.50 Formula: C22H32O2 CLOGP: 7.48 LIPINSKI: 1 HAC: 2 HDO: 1 TPSA: 37.30 ALOGS: -6.25 ROTB: 14

Molecule

Description

Molfile Inchi Smiles

Synonyms:

docosahexaenoic acid
doconexent
cervonic acid
efalex

a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement

Molecular weight: 328.50
Formula: C22H32O2
CLOGP: 7.48
LIPINSKI: 1
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -6.25
ROTB: 14

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	158.67	40.06	66	4139	34474	63450343
Coma	119.54	40.06	66	4139	64298	63420519
Gastrooesophageal reflux disease	95.44	40.06	66	4139	95573	63389244
Muscle spasticity	84.62	40.06	37	4168	21757	63463060
Rheumatic disorder	81.29	40.06	22	4183	3050	63481767
Respiratory disorder	72.27	40.06	40	4165	39042	63445775
Blood immunoglobulin M increased	69.76	40.06	16	4189	1127	63483690
Body temperature increased	68.59	40.06	38	4167	37154	63447663
Incorrect route of product administration	67.51	40.06	34	4171	27418	63457399
Blood immunoglobulin A decreased	67.51	40.06	16	4189	1301	63483516

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Child abuse	89.40	42.51	16	4094	413	79739865
Rheumatic disorder	86.16	42.51	22	4088	3136	79737142
Pneumonia aspiration	79.42	42.51	47	4063	66920	79673358
Epidural lipomatosis	78.18	42.51	17	4093	1211	79739067
Muscle spasticity	73.52	42.51	31	4079	21444	79718834
Blood immunoglobulin M increased	70.92	42.51	16	4094	1350	79738928
Blood immunoglobulin A decreased	69.94	42.51	16	4094	1437	79738841
Incorrect route of product administration	67.83	42.51	34	4076	34895	79705383
Psoriatic arthropathy	65.50	42.51	44	4066	77955	79662323
Cataract operation	62.33	42.51	19	4091	5166	79735112

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:83146	Daphnia tenebrosa metabolites
CHEBI has role	CHEBI:84735	algal metabolites

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID
Pregnancy, function	indication	289908002
Breastfeeding (mother)	indication	413712001
Prevention of Fetal Neural Tube Defects during Pregnancy	off-label use

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.37	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Aromatase	Enzyme	P11511	CP19A_HUMAN		IC50	4.48	CHEMBL
Retinoic acid receptor RXR-alpha	Nuclear hormone receptor	P19793	RXRA_HUMAN		Ki	5.20	CHEMBL
Free fatty acid receptor 1	GPCR	O14842	FFAR1_HUMAN	AGONIST	EC50	6	IUPHAR
Oxoeicosanoid receptor 1	GPCR	Q8TDS5	OXER1_HUMAN		IC50	5.70	CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_SHEEP		IC50	5.01	CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_BOVIN		IC50	4.82	CHEMBL
Transient receptor potential cation channel subfamily A member 1	Ion channel		TRPA1_RAT	ACTIVATOR	EC50	4.40	IUPHAR

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External reference:

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ID	Source
002051	NDDF
1006469	RXNORM
1051	IUPHAR_LIGAND_ID
226368001	SNOMEDCT_US
4020132	VUID
4020132	VANDF
445580	PUBCHEM_CID
6428	INN_ID
C2348308	UMLSCUI
C532150	MESH_SUPPLEMENTAL_RECORD_UI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Animi-3	HUMAN PRESCRIPTION DRUG LABEL	8	66213-543	CAPSULE	250 mg	ORAL	unapproved drug other	14 sections
Animi-3 with Vitamin D	HUMAN PRESCRIPTION DRUG LABEL	8	66213-542	CAPSULE	250 mg	ORAL	unapproved drug other	14 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0798	CAPSULE, GELATIN COATED	260 mg	ORAL	UNAPPROVED DRUG OTHER	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0799	CAPSULE, GELATIN COATED	250 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0812	CAPSULE, GELATIN COATED	250 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	260 mg	ORAL	unapproved drug other	10 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	260 mg	ORAL	unapproved drug other	10 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	200 mg	ORAL	unapproved drug other	10 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	200 mg	ORAL	unapproved drug other	10 sections
PNV-DHA	HUMAN PRESCRIPTION DRUG LABEL	10	42192-321	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	11 sections

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