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Property	Description	Value
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70	52
kinase-selectivity-class	GRK2,MAP2K6,STK33,TEK	4
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Psoriatic arthropathy	113.66	32.51	146	11961	228189	90388151
Pneumonia aspiration	109.02	32.51	68	12039	40872	90575468
Hepatic necrosis	77.45	32.51	30	12077	6408	90609932
Rheumatic disorder	75.62	32.51	25	12082	3383	90612957
Coma	74.25	32.51	68	12039	72564	90543776
Blood immunoglobulin M increased	69.38	32.51	19	12088	1353	90614987
Type 2 diabetes mellitus	67.16	32.51	107	12000	203137	90413203
Blood immunoglobulin A decreased	64.74	32.51	19	12088	1737	90614603
Muscle injury	63.93	32.51	97	12010	176557	90439783
Liver injury	63.64	32.51	95	12012	170472	90445868
Pericarditis	63.00	32.51	122	11985	270029	90346311
Mobility decreased	61.87	32.51	116	11991	250618	90365722
Lower respiratory tract infection	59.42	32.51	114	11993	250545	90365795
Stomatitis	56.80	32.51	118	11989	274580	90341760
Muscle spasticity	56.80	32.51	43	12064	35279	90581061
Hepatic encephalopathy	55.62	32.51	30	12077	13742	90602598
Drug-induced liver injury	54.96	32.51	64	12043	90254	90526086
Blood immunoglobulin G increased	54.91	32.51	19	12088	2953	90613387
Urticaria	54.06	32.51	125	11982	312609	90303731
Fall	52.32	32.51	3	12104	481807	90134533
Hepatic enzyme abnormal	49.68	32.51	23	12084	7619	90608721
Nasopharyngitis	48.99	32.51	142	11965	406962	90209378
Incorrect route of product administration	47.11	32.51	45	12062	50581	90565759
Rheumatoid arthritis	47.05	32.51	130	11977	362484	90253856
Colitis microscopic	47.00	32.51	25	12082	11134	90605206
Gastrooesophageal reflux disease	46.13	32.51	81	12026	166256	90450084
Musculoskeletal pain	45.70	32.51	82	12025	171169	90445171
Night sweats	45.56	32.51	70	12037	128696	90487644
Sinusitis	45.50	32.51	124	11983	342964	90273376
Pemphigus	45.22	32.51	120	11987	326744	90289596
Cataract operation	44.64	32.51	20	12087	6143	90610197
C-reactive protein	43.52	32.51	35	12072	31332	90585008
Ear pain	42.16	32.51	45	12062	57657	90558683
Hernia	41.33	32.51	25	12082	14206	90602134
Lip dry	40.18	32.51	58	12049	100897	90515443
Skin reaction	39.98	32.51	27	12080	18526	90597814
Multiple allergies	39.90	32.51	25	12082	15121	90601219
Red blood cell sedimentation rate increased	39.72	32.51	52	12055	82543	90533797
Body temperature increased	38.33	32.51	38	12069	44672	90571668
Respiratory disorder	37.88	32.51	45	12062	64771	90551569
Helicobacter infection	36.25	32.51	88	12019	226762	90389578
Fibromyalgia	36.20	32.51	83	12024	206186	90410154
Anaemia	35.95	32.51	3	12104	352799	90263541
Joint swelling	35.49	32.51	147	11960	503153	90113187
Wound infection	35.07	32.51	56	12051	106346	90509994
Death	34.88	32.51	9	12098	456542	90159798
Lupus vulgaris	34.44	32.51	36	12071	45023	90571317
Multiple fractures	33.58	32.51	19	12088	9543	90606797
Osteoarthritis	33.51	32.51	78	12029	195652	90420688
Contraindicated product administered	33.15	32.51	106	12001	320033	90296307
Cough	32.93	32.51	5	12102	368957	90247383
Glaucoma	32.77	32.51	25	12082	20730	90595610

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Child abuse	197.83	83.00	32	1147	860	42619296
Epidural lipomatosis	188.44	83.00	34	1145	1766	42618390
Juvenile idiopathic arthritis	175.45	83.00	34	1145	2605	42617551
Respiratory depression	130.40	83.00	39	1140	18829	42601327
Product prescribing error	117.92	83.00	39	1140	26073	42594083
Drug dependence	113.78	83.00	39	1140	29055	42591101
Obesity	113.59	83.00	34	1145	16425	42603731
Victim of child abuse	108.41	83.00	20	1159	1169	42618987
Intentional product misuse	85.21	83.00	39	1140	61861	42558295

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Child abuse	155.71	36.09	32	11298	857	110577112
Epidural lipomatosis	138.94	36.09	34	11296	2033	110575936
Psoriatic arthropathy	112.88	36.09	119	11211	196642	110381327
Juvenile idiopathic arthritis	103.07	36.09	34	11296	5973	110571996
Obesity	102.09	36.09	88	11242	113263	110464706
Victim of child abuse	81.80	36.09	20	11310	1191	110576778
Rheumatic disorder	80.87	36.09	25	11305	3566	110574403
Hepatic necrosis	72.60	36.09	30	11300	9892	110568077
Blood immunoglobulin M increased	71.05	36.09	19	11311	1618	110576351
Rheumatoid arthritis	70.58	36.09	117	11213	299496	110278473
Lower respiratory tract infection	68.40	36.09	103	11227	243003	110334966
Muscle injury	68.24	36.09	78	11252	140729	110437240
Pemphigus	66.26	36.09	95	11235	214475	110363494
Blood immunoglobulin A decreased	65.09	36.09	19	11311	2229	110575740
Pericarditis	63.29	36.09	94	11236	219020	110358949
Incorrect route of product administration	62.28	36.09	52	11278	64009	110513960
Mobility decreased	61.73	36.09	97	11233	237325	110340644
Respiratory depression	60.91	36.09	39	11291	31962	110546007
Liver injury	60.85	36.09	76	11254	150337	110427632
Musculoskeletal pain	59.40	36.09	83	11247	182940	110395029
Nasopharyngitis	58.04	36.09	126	11204	394235	110183734
Contraindicated product administered	57.16	36.09	96	11234	248171	110329798
Blood immunoglobulin G increased	55.23	36.09	19	11311	3789	110574180
Lip dry	54.60	36.09	59	11271	100024	110477945
Type 2 diabetes mellitus	54.01	36.09	78	11252	177154	110400815
Helicobacter infection	53.91	36.09	79	11251	181798	110396171
Product use issue	53.35	36.09	106	11224	311589	110266380
Red blood cell sedimentation rate increased	53.30	36.09	52	11278	78250	110499719
Acute kidney injury	53.04	36.09	3	11327	635427	109942542
C-reactive protein	52.91	36.09	35	11295	30296	110547673
Systemic lupus erythematosus	52.86	36.09	94	11236	254244	110323725
Drug-induced liver injury	52.32	36.09	63	11267	120004	110457965
Muscle spasticity	52.13	36.09	37	11293	35878	110542091
Multiple allergies	51.05	36.09	25	11305	12238	110565731
Cataract operation	50.66	36.09	20	11310	5863	110572106
Hepatic enzyme abnormal	50.13	36.09	23	11307	9740	110568229
Night sweats	49.92	36.09	65	11265	133918	110444051
Fall	49.90	36.09	3	11327	603479	109974490
Osteoarthritis	49.38	36.09	76	11254	182547	110395422
Colitis microscopic	48.96	36.09	25	11305	13369	110564600
Arthropathy	48.26	36.09	97	11233	287425	110290544
Fibromyalgia	47.44	36.09	72	11258	170837	110407132
Pneumonia aspiration	46.27	36.09	49	11281	81184	110496785
Drug dependence	45.33	36.09	39	11291	49981	110527988
Product prescribing error	44.45	36.09	39	11291	51292	110526677
Nausea	44.44	36.09	37	11293	1235653	109342316
Death	44.11	36.09	9	11321	698860	109879109
Skin reaction	43.31	36.09	27	11303	21117	110556852
Ear pain	43.23	36.09	39	11291	53187	110524782
Hepatic encephalopathy	43.08	36.09	30	11300	28226	110549743
Nail disorder	42.30	36.09	40	11290	57895	110520074
Facet joint syndrome	40.86	36.09	50	11280	96778	110481191
Joint swelling	40.39	36.09	118	11212	442727	110135242
Lupus vulgaris	40.38	36.09	31	11299	33852	110544117
Hernia	40.19	36.09	25	11305	19475	110558494
Duodenal ulcer perforation	39.92	36.09	68	11262	177632	110400337
Multiple fractures	39.54	36.09	19	11311	8921	110569048
Hypotension	39.39	36.09	4	11326	523845	110054124
Hypoaesthesia	39.09	36.09	94	11236	314129	110263840
Wound infection	37.81	36.09	48	11282	96417	110481552
Hepatic cirrhosis	37.11	36.09	40	11290	67586	110510383
Glaucoma	36.90	36.09	25	11305	22492	110555477
Sciatica	36.25	36.09	46	11284	92353	110485616

Disease	Relation	SNOMED_ID
Pregnancy, function	indication	289908002
Breastfeeding (mother)	indication	413712001
Prevention of Fetal Neural Tube Defects during Pregnancy	off-label use

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General architecture

Using the assistant

doconexent 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Aromatase	Enzyme	P11511	CP19A_HUMAN		IC50	4.48	CHEMBL
Retinoic acid receptor RXR-alpha	Nuclear hormone receptor	P19793	RXRA_HUMAN		Ki	5.20	CHEMBL
Free fatty acid receptor 1	GPCR	O14842	FFAR1_HUMAN	AGONIST	EC50	6	IUPHAR
Oxoeicosanoid receptor 1	GPCR	Q8TDS5	OXER1_HUMAN		IC50	5.70	CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_SHEEP		IC50	5.01	CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_BOVIN		IC50	4.82	CHEMBL
Transient receptor potential cation channel subfamily A member 1	Ion channel		TRPA1_RAT	ACTIVATOR	EC50	4.40	IUPHAR

ID	Source
4020132	VUID
N0000148111	NUI
4020132	VANDF
C2348308	UMLSCUI
CHEBI:28125	CHEBI
CHEMBL367149	ChEMBL_ID
DB03756	DRUGBANK_ID
6428	INN_ID
ZAD9OKH9JC	UNII
445580	PUBCHEM_CID
1006469	RXNORM
002051	NDDF
226368001	SNOMEDCT_US
F22	PDB_CHEM_ID
HXA	PDB_CHEM_ID
1051	IUPHAR_LIGAND_ID
C532150	MESH_SUPPLEMENTAL_RECORD_UI

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0798	CAPSULE, GELATIN COATED	260 mg	ORAL	UNAPPROVED DRUG OTHER	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0799	CAPSULE, GELATIN COATED	250 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0812	CAPSULE, GELATIN COATED	250 mg	ORAL	Unapproved drug other	11 sections
VitafolUltra	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0093	CAPSULE, LIQUID FILLED	200 mg	ORAL	unapproved drug other	13 sections
Vitafol Fe Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-7473	CAPSULE, LIQUID FILLED	200 mg	ORAL	unapproved drug other	14 sections
TriStart DHA	HUMAN PRESCRIPTION DRUG LABEL	15	15370-250	CAPSULE, LIQUID FILLED	200 mg	ORAL	UNAPPROVED DRUG OTHER	12 sections
BP Vit 3	HUMAN PRESCRIPTION DRUG LABEL	7	42192-301	CAPSULE, COATED	350 mg	ORAL	unapproved drug other	7 sections
PNV-DHA	HUMAN PRESCRIPTION DRUG LABEL	10	42192-321	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	11 sections
PNV-DHA	HUMAN PRESCRIPTION DRUG LABEL	8	42192-323	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	11 sections
PNV-Omega	HUMAN PRESCRIPTION DRUG LABEL	13	42192-332	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	12 sections
Animi-3 with Vitamin D	HUMAN PRESCRIPTION DRUG LABEL	8	66213-542	CAPSULE	250 mg	ORAL	unapproved drug other	14 sections
Animi-3	HUMAN PRESCRIPTION DRUG LABEL	8	66213-543	CAPSULE	250 mg	ORAL	unapproved drug other	14 sections
PRENATE Restore	HUMAN PRESCRIPTION DRUG LABEL	12	75854-308	CAPSULE, GELATIN COATED	400 mg	ORAL	unapproved drug other	13 sections
PRENATE Enhance	HUMAN PRESCRIPTION DRUG LABEL	12	75854-309	CAPSULE, GELATIN COATED	400 mg	ORAL	unapproved drug other	11 sections
PRENATE DHA	HUMAN PRESCRIPTION DRUG LABEL	11	75854-312	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	12 sections
Prenate Essential	HUMAN PRESCRIPTION DRUG LABEL	14	75854-313	CAPSULE, GELATIN COATED	300 mg	ORAL	unapproved drug other	13 sections
Prenate Mini	HUMAN PRESCRIPTION DRUG LABEL	15	75854-315	CAPSULE, GELATIN COATED	350 mg	ORAL	unapproved drug other	12 sections
Prenate Pixie	HUMAN PRESCRIPTION DRUG LABEL	12	75854-316	TABLET, FILM COATED	200 mg	ORAL	unapproved drug other	12 sections