allantoin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiepileptics, hydantoin derivatives 4268 97-59-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • allantoin
  • 5-Ureidohydantoin
  • allantion
  • allantol
  • glyoxyldiureid
  • glyoxyldiureide
  • glyoxylic diureide
A urea hydantoin that is found in URINE and PLANTS and is used in dermatological preparations.
  • Molecular weight: 158.12
  • Formula: C4H6N4O3
  • CLOGP: -1.91
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 113.32
  • ALOGS: -1.52
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 320.43 16.54 100 5281 14288 50585455
Methaemoglobinaemia 184.79 16.54 43 5338 1999 50597744
Sedation complication 64.88 16.54 27 5354 8739 50591004
Creatinine renal clearance decreased 63.21 16.54 29 5352 11852 50587891
Blood calcium decreased 53.27 16.54 31 5350 20675 50579068
Sedation 51.48 16.54 35 5346 30575 50569168
Orthostatic hypotension 45.55 16.54 32 5349 29449 50570294
Depressed level of consciousness 42.85 16.54 39 5342 51914 50547829
Product complaint 40.03 16.54 21 5360 11445 50588298
Cognitive disorder 34.20 16.54 32 5349 44091 50555652
Constipation 33.59 16.54 66 5315 185642 50414101
Drug ineffective 32.10 16.54 171 5210 819162 49780581
Cyanosis 31.98 16.54 20 5361 15164 50584579
Balance disorder 24.93 16.54 34 5347 70556 50529187
Paraesthesia oral 23.01 16.54 15 5366 12206 50587537
Pustule 21.29 16.54 7 5374 1171 50598572
Chronic sinusitis 20.72 16.54 11 5370 6134 50593609
Mobility decreased 17.66 16.54 31 5350 79917 50519826
Superinfection 17.49 16.54 7 5374 2049 50597694
Alopecia 16.62 16.54 3 5378 245044 50354699

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 83.80 16.54 26 4268 2645 29567588
Product complaint 33.05 16.54 16 4278 5389 29564844
Aspartate aminotransferase increased 22.59 16.54 35 4259 59690 29510543
Alanine aminotransferase increased 22.00 16.54 38 4256 70906 29499327
Disseminated intravascular coagulation 17.78 16.54 18 4276 19962 29550271

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 245.28 14.20 66 8807 4282 64485577
Sedation complication 56.86 14.20 28 8845 10326 64479533
Creatinine renal clearance decreased 56.25 14.20 31 8842 14390 64475469
Blood calcium decreased 49.01 14.20 35 8838 25519 64464340
Product complaint 47.46 14.20 26 8847 11928 64477931
Sedation 43.68 14.20 40 8833 41422 64448437
Depressed level of consciousness 36.08 14.20 50 8823 81386 64408473
Aspartate aminotransferase increased 32.83 14.20 59 8814 119729 64370130
Cyanosis 32.81 14.20 26 8847 22129 64467730
Orthostatic hypotension 32.49 14.20 36 8837 46702 64443157
Constipation 28.98 14.20 83 8790 229254 64260605
Alanine aminotransferase increased 28.97 14.20 61 8812 138970 64350889
Cognitive disorder 23.17 14.20 33 8840 55054 64434805
Platelet count decreased 18.61 14.20 58 8815 167653 64322206
Pustule 18.52 14.20 7 8866 1358 64488501
Lymphocyte count decreased 18.03 14.20 25 8848 40674 64449185
Balance disorder 17.67 14.20 37 8836 83889 64405970
Product dose omission issue 17.26 14.20 3 8870 194744 64295115
Peripheral swelling 16.92 14.20 4 8869 209149 64280710
Paraesthesia oral 16.48 14.20 14 8859 13117 64476742
Macular degeneration 16.23 14.20 10 8863 5700 64484159
Off label use 15.30 14.20 41 8832 632765 63857094
Neutrophil count increased 15.14 14.20 18 8855 25156 64464703

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003879 Dermatologic Agents
CHEBI has role CHEBI:73336 wound-healing drug
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893
Seborrheic dermatitis indication 50563003 DOID:8741
Pityriasis simplex indication 200767005
Skin irritation indication 367466007
Itching of skin indication 418363000
Minor Skin Wound Pain indication
Folliculitis contraindication 13600006 DOID:4409
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Open wound contraindication 125643001
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Disease of liver contraindication 235856003 DOID:409
Porphyria contraindication 418470004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.71 acidic
pKa2 10.76 acidic
pKa3 11.46 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018613 VUID
N0000146926 NUI
D00121 KEGG_DRUG
4018613 VANDF
C0002083 UMLSCUI
CHEBI:15676 CHEBI
2AL PDB_CHEM_ID
CHEMBL593429 ChEMBL_ID
D000481 MESH_DESCRIPTOR_UI
DB11100 DRUGBANK_ID
344S277G0Z UNII
204 PUBCHEM_CID
508 RXNORM
4149 MMSL
72840 MMSL
002009 NDDF
395933009 SNOMEDCT_US
404834008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Mederma for Kids HUMAN OTC DRUG LABEL 1 0259-1101 GEL 10 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Mederma for Kids HUMAN OTC DRUG LABEL 1 0259-1101 GEL 10 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Mederma Advanced Scar HUMAN OTC DRUG LABEL 1 0259-1105 GEL 5 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Mederma Advanced Scar HUMAN OTC DRUG LABEL 1 0259-1105 GEL 5 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Cetaphil Baby Soothe and Protect Cream HUMAN OTC DRUG LABEL 1 0299-4103 CREAM 5 mg TOPICAL OTC monograph final 7 sections
Cetaphil Baby Soothe and Protect Cream HUMAN OTC DRUG LABEL 1 0299-4103 CREAM 5 mg TOPICAL OTC monograph final 7 sections
Cetaphil Soothing Gel Cream HUMAN OTC DRUG LABEL 1 0299-4105 CREAM 5 mg TOPICAL OTC monograph final 7 sections
Cetaphil Soothing Gel Cream HUMAN OTC DRUG LABEL 1 0299-4105 CREAM 5 mg TOPICAL OTC monograph final 7 sections
Walgreens Advanced Scar Gel HUMAN OTC DRUG LABEL 1 0363-2312 GEL 5 mg TOPICAL OTC monograph final 12 sections
Scar HUMAN OTC DRUG LABEL 1 0363-3131 GEL 0.50 g TOPICAL OTC monograph final 12 sections
ANBESOL COLD SORE THERAPY HUMAN OTC DRUG LABEL 4 0573-0246 OINTMENT 10 mg TOPICAL OTC monograph not final 14 sections
Orajel Cold Sore Moisturelock HUMAN OTC DRUG LABEL 6 10237-761 CREAM 5 mg TOPICAL OTC monograph not final 12 sections
TRIDERMA PROTECT AND HEAL NON- GREASY BARRIER HUMAN OTC DRUG LABEL 2 10738-061 CREAM 1.50 g TOPICAL OTC monograph final 11 sections
TriDerma Stubborn Diaper Rash Relief HUMAN OTC DRUG LABEL 2 10738-068 CREAM 1.50 g TOPICAL OTC monograph final 11 sections
SBS 40 HUMAN OTC DRUG LABEL 1 11084-040 LOTION 0.50 mL TOPICAL OTC monograph final 11 sections
Cool Melon HUMAN OTC DRUG LABEL 1 11084-042 CREAM 0.50 mL TOPICAL OTC monograph final 9 sections
SBS 41 Medicated Cream HUMAN OTC DRUG LABEL 1 11084-141 CREAM 5 mg TOPICAL OTC monograph final 11 sections
SBS 40 HUMAN OTC DRUG LABEL 1 11084-240 CREAM 5 mg TOPICAL OTC monograph final 11 sections
SBS 40 Medicated Cream HUMAN OTC DRUG LABEL 1 11084-241 CREAM 5 mg TOPICAL OTC monograph final 11 sections
Sheffield Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11527-725 GEL 5 mg TOPICAL OTC monograph final 12 sections
Target Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11673-725 GEL 5 mg TOPICAL OTC monograph final 12 sections
Target Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11673-725 GEL 5 mg TOPICAL OTC monograph final 12 sections
Scar Care HUMAN OTC DRUG LABEL 1 11673-777 GEL 0.50 g TOPICAL OTC monograph final 11 sections
Rite Aid Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11822-8214 GEL 5 mg TOPICAL OTC monograph final 12 sections
SOOTHE Sensitive Skin Treatment HUMAN OTC DRUG LABEL 2 14222-2420 LOTION 0.50 g TOPICAL OTC monograph final 12 sections
Bodyglide anti chafe balm HUMAN OTC DRUG LABEL 1 15197-007 STICK 5 mg TOPICAL OTC MONOGRAPH FINAL 8 sections
Chamois Glide HUMAN OTC DRUG LABEL 1 15197-008 STICK 5 mg TOPICAL OTC MONOGRAPH FINAL 8 sections
Bodyglide For Her HUMAN OTC DRUG LABEL 1 15197-009 STICK 5 mg TOPICAL OTC MONOGRAPH FINAL 8 sections
DE LA CRUZ DIAPER RASH HUMAN OTC DRUG LABEL 3 24286-1566 OINTMENT 1 g TOPICAL OTC MONOGRAPH FINAL 13 sections
Run Guard Original HUMAN OTC DRUG LABEL 1 24474-001 STICK 0.50 g TOPICAL OTC monograph final 9 sections