allantoin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiepileptics, hydantoin derivatives | 4268 | 97-59-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A urea hydantoin that is found in URINE and PLANTS and is used in dermatological preparations.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Macular degeneration | 283.79 | 16.09 | 100 | 5684 | 24276 | 63458962 |
| Methaemoglobinaemia | 189.73 | 16.09 | 44 | 5740 | 2359 | 63480879 |
| Creatinine renal clearance decreased | 58.72 | 16.09 | 29 | 5755 | 16279 | 63466959 |
| Sedation complication | 57.08 | 16.09 | 27 | 5757 | 13795 | 63469443 |
| Blood calcium decreased | 50.67 | 16.09 | 31 | 5753 | 26420 | 63456818 |
| Sedation | 48.86 | 16.09 | 35 | 5749 | 38774 | 63444464 |
| Orthostatic hypotension | 44.12 | 16.09 | 32 | 5752 | 36128 | 63447110 |
| Depressed level of consciousness | 42.06 | 16.09 | 39 | 5745 | 62039 | 63421199 |
| Product complaint | 40.89 | 16.09 | 21 | 5763 | 12788 | 63470450 |
| Cyanosis | 32.82 | 16.09 | 20 | 5764 | 16915 | 63466323 |
| Cognitive disorder | 32.01 | 16.09 | 32 | 5752 | 55783 | 63427455 |
| Constipation | 31.87 | 16.09 | 66 | 5718 | 224877 | 63258361 |
| Drug ineffective | 27.95 | 16.09 | 176 | 5608 | 1044589 | 62438649 |
| Balance disorder | 24.29 | 16.09 | 34 | 5750 | 84388 | 63398850 |
| Pustule | 19.84 | 16.09 | 7 | 5777 | 1692 | 63481546 |
| Paraesthesia oral | 18.96 | 16.09 | 15 | 5769 | 19241 | 63463997 |
| Alopecia | 18.65 | 16.09 | 4 | 5780 | 337532 | 63145706 |
| Superinfection | 16.93 | 16.09 | 7 | 5777 | 2600 | 63480638 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blood phosphorus increased | 159.21 | 17.26 | 57 | 5919 | 7664 | 34943291 |
| Methaemoglobinaemia | 149.16 | 17.26 | 45 | 5931 | 3536 | 34947419 |
| Appendicolith | 145.91 | 17.26 | 55 | 5921 | 8546 | 34942409 |
| Appendicitis | 117.09 | 17.26 | 55 | 5921 | 14752 | 34936203 |
| Ventricular fibrillation | 102.38 | 17.26 | 58 | 5918 | 22896 | 34928059 |
| Cardiogenic shock | 89.34 | 17.26 | 56 | 5920 | 26562 | 34924393 |
| Stress | 87.44 | 17.26 | 58 | 5918 | 30289 | 34920666 |
| Dry mouth | 82.94 | 17.26 | 56 | 5920 | 30109 | 34920846 |
| Ascites | 77.62 | 17.26 | 64 | 5912 | 46507 | 34904448 |
| Abdominal distension | 74.57 | 17.26 | 69 | 5907 | 58423 | 34892532 |
| Myasthenia gravis | 68.16 | 17.26 | 30 | 5946 | 6910 | 34944045 |
| Blood uric acid increased | 61.74 | 17.26 | 31 | 5945 | 9593 | 34941362 |
| Multiple organ dysfunction syndrome | 60.73 | 17.26 | 70 | 5906 | 76496 | 34874459 |
| Hyponatraemia | 56.38 | 17.26 | 70 | 5906 | 82621 | 34868334 |
| Vomiting | 44.75 | 17.26 | 117 | 5859 | 247504 | 34703451 |
| Abdominal pain | 44.66 | 17.26 | 91 | 5885 | 163527 | 34787428 |
| Blood cholesterol increased | 37.92 | 17.26 | 30 | 5946 | 20513 | 34930442 |
| Sepsis | 36.70 | 17.26 | 85 | 5891 | 166476 | 34784479 |
| Analgesic therapy | 35.01 | 17.26 | 11 | 5965 | 987 | 34949968 |
| Incorrect route of product administration | 34.77 | 17.26 | 25 | 5951 | 14820 | 34936135 |
| Sleep disorder therapy | 34.74 | 17.26 | 11 | 5965 | 1012 | 34949943 |
| Somnolence | 34.14 | 17.26 | 65 | 5911 | 111051 | 34839904 |
| Drug therapy | 33.56 | 17.26 | 11 | 5965 | 1130 | 34949825 |
| General physical health deterioration | 31.07 | 17.26 | 68 | 5908 | 128201 | 34822754 |
| Iron deficiency | 30.64 | 17.26 | 16 | 5960 | 5365 | 34945590 |
| Hyperphosphataemia | 30.54 | 17.26 | 15 | 5961 | 4422 | 34946533 |
| Product complaint | 29.28 | 17.26 | 16 | 5960 | 5874 | 34945081 |
| Condition aggravated | 24.23 | 17.26 | 80 | 5896 | 192116 | 34758839 |
| Nausea | 24.00 | 17.26 | 118 | 5858 | 339790 | 34611165 |
| Neuralgia | 23.54 | 17.26 | 20 | 5956 | 15093 | 34935862 |
| Bacterial infection | 23.40 | 17.26 | 21 | 5955 | 17042 | 34933913 |
| Hypophosphataemia | 20.12 | 17.26 | 16 | 5960 | 11010 | 34939945 |
| Haemolysis | 19.80 | 17.26 | 14 | 5962 | 8080 | 34942875 |
| Aspartate aminotransferase increased | 18.78 | 17.26 | 38 | 5938 | 67745 | 34883210 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Methaemoglobinaemia | 321.47 | 14.97 | 86 | 10859 | 5471 | 79727972 |
| Appendicolith | 157.90 | 14.97 | 55 | 10890 | 8496 | 79724947 |
| Blood phosphorus increased | 155.02 | 14.97 | 57 | 10888 | 10290 | 79723153 |
| Appendicitis | 113.68 | 14.97 | 56 | 10889 | 20738 | 79712705 |
| Ventricular fibrillation | 101.54 | 14.97 | 60 | 10885 | 31866 | 79701577 |
| Cardiogenic shock | 77.31 | 14.97 | 56 | 10889 | 41858 | 79691585 |
| Ascites | 74.20 | 14.97 | 70 | 10875 | 75492 | 79657951 |
| Myasthenia gravis | 65.89 | 14.97 | 31 | 10914 | 10368 | 79723075 |
| Blood uric acid increased | 64.25 | 14.97 | 33 | 10912 | 13327 | 79720116 |
| Stress | 60.19 | 14.97 | 64 | 10881 | 79548 | 79653895 |
| Abdominal distension | 58.57 | 14.97 | 77 | 10868 | 119573 | 79613870 |
| Dry mouth | 54.91 | 14.97 | 64 | 10881 | 87955 | 79645488 |
| Multiple organ dysfunction syndrome | 52.19 | 14.97 | 73 | 10872 | 120173 | 79613270 |
| Creatinine renal clearance decreased | 48.38 | 14.97 | 31 | 10914 | 18971 | 79714472 |
| Hyponatraemia | 46.89 | 14.97 | 86 | 10859 | 177762 | 79555681 |
| Sedation complication | 46.04 | 14.97 | 28 | 10917 | 15641 | 79717802 |
| Product complaint | 44.83 | 14.97 | 26 | 10919 | 13323 | 79720120 |
| Blood calcium decreased | 44.35 | 14.97 | 36 | 10909 | 31783 | 79701660 |
| Analgesic therapy | 37.27 | 14.97 | 11 | 10934 | 998 | 79732445 |
| Sleep disorder therapy | 37.11 | 14.97 | 11 | 10934 | 1013 | 79732430 |
| Abdominal pain | 36.58 | 14.97 | 127 | 10818 | 389442 | 79344001 |
| Sedation | 36.20 | 14.97 | 40 | 10905 | 51855 | 79681588 |
| Drug therapy | 35.38 | 14.97 | 11 | 10934 | 1190 | 79732253 |
| Hyperphosphataemia | 34.32 | 14.97 | 17 | 10928 | 6359 | 79727084 |
| Sepsis | 32.72 | 14.97 | 96 | 10849 | 269332 | 79464111 |
| Aspartate aminotransferase increased | 30.35 | 14.97 | 62 | 10883 | 138579 | 79594864 |
| Cyanosis | 29.95 | 14.97 | 26 | 10919 | 25156 | 79708287 |
| Depressed level of consciousness | 29.67 | 14.97 | 50 | 10895 | 96602 | 79636841 |
| Orthostatic hypotension | 27.23 | 14.97 | 36 | 10909 | 56128 | 79677315 |
| Vomiting | 26.57 | 14.97 | 169 | 10776 | 665659 | 79067784 |
| Iron deficiency | 26.18 | 14.97 | 17 | 10928 | 10637 | 79722806 |
| Somnolence | 25.13 | 14.97 | 81 | 10864 | 238900 | 79494543 |
| Alanine aminotransferase increased | 23.75 | 14.97 | 62 | 10883 | 162508 | 79570935 |
| Constipation | 23.74 | 14.97 | 89 | 10856 | 282961 | 79450482 |
| Bacterial infection | 23.36 | 14.97 | 25 | 10920 | 31255 | 79702188 |
| Incorrect route of product administration | 22.77 | 14.97 | 26 | 10919 | 34903 | 79698540 |
| Peripheral swelling | 22.04 | 14.97 | 5 | 10940 | 269612 | 79463831 |
| Haemolysis | 18.92 | 14.97 | 15 | 10930 | 12797 | 79720646 |
| Joint swelling | 18.86 | 14.97 | 8 | 10937 | 288638 | 79444805 |
| Arthralgia | 17.87 | 14.97 | 32 | 10913 | 571771 | 79161672 |
| Product dose omission issue | 17.61 | 14.97 | 6 | 10939 | 247531 | 79485912 |
| Cognitive disorder | 17.38 | 14.97 | 33 | 10912 | 69893 | 79663550 |
| Fatigue | 16.97 | 14.97 | 68 | 10877 | 929659 | 78803784 |
| Nausea | 16.95 | 14.97 | 203 | 10742 | 956993 | 78776450 |
| Hypophosphataemia | 16.82 | 14.97 | 17 | 10928 | 19896 | 79713547 |
| Pustule | 15.86 | 14.97 | 7 | 10938 | 2018 | 79731425 |
| Alopecia | 15.79 | 14.97 | 6 | 10939 | 231349 | 79502094 |
| Lymphocyte count decreased | 15.22 | 14.97 | 25 | 10920 | 47264 | 79686179 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003879 | Dermatologic Agents |
| CHEBI has role | CHEBI:73336 | wound-healing drug |
| CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
| CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Psoriasis | indication | 9014002 | DOID:8893 |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Pityriasis simplex | indication | 200767005 | |
| Skin irritation | indication | 367466007 | |
| Itching of skin | indication | 418363000 | |
| Minor Skin Wound Pain | indication | ||
| Folliculitis | contraindication | 13600006 | DOID:4409 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Open wound | contraindication | 125643001 | |
| Disease of blood AND/OR blood-forming organ | contraindication | 191124002 | DOID:74 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Porphyria | contraindication | 418470004 | |
| Inflammatory dermatosis | contraindication | 703938007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.71 | acidic |
| pKa2 | 10.76 | acidic |
| pKa3 | 11.46 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018613 | VUID |
| N0000146926 | NUI |
| D00121 | KEGG_DRUG |
| 4018613 | VANDF |
| C0002083 | UMLSCUI |
| CHEBI:15676 | CHEBI |
| 2AL | PDB_CHEM_ID |
| CHEMBL593429 | ChEMBL_ID |
| D000481 | MESH_DESCRIPTOR_UI |
| DB11100 | DRUGBANK_ID |
| 344S277G0Z | UNII |
| 204 | PUBCHEM_CID |
| 508 | RXNORM |
| 4149 | MMSL |
| 72840 | MMSL |
| 002009 | NDDF |
| 395933009 | SNOMEDCT_US |
| 404834008 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Mederma for Kids | HUMAN OTC DRUG LABEL | 1 | 0259-1101 | GEL | 10 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| Mederma for Kids | HUMAN OTC DRUG LABEL | 1 | 0259-1101 | GEL | 10 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| Mederma Advanced Scar | HUMAN OTC DRUG LABEL | 1 | 0259-1105 | GEL | 5 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| Mederma Advanced Scar | HUMAN OTC DRUG LABEL | 1 | 0259-1105 | GEL | 5 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| Cetaphil Baby Soothe and Protect Cream | HUMAN OTC DRUG LABEL | 1 | 0299-4103 | CREAM | 5 mg | TOPICAL | OTC monograph final | 7 sections |
| Cetaphil Baby Soothe and Protect Cream | HUMAN OTC DRUG LABEL | 1 | 0299-4103 | CREAM | 5 mg | TOPICAL | OTC monograph final | 7 sections |
| Cetaphil Soothing Gel Cream | HUMAN OTC DRUG LABEL | 1 | 0299-4105 | CREAM | 5 mg | TOPICAL | OTC monograph final | 7 sections |
| Cetaphil Soothing Gel Cream | HUMAN OTC DRUG LABEL | 1 | 0299-4105 | CREAM | 5 mg | TOPICAL | OTC monograph final | 7 sections |
| Walgreens Advanced Scar Gel | HUMAN OTC DRUG LABEL | 1 | 0363-2312 | GEL | 5 mg | TOPICAL | OTC monograph final | 12 sections |
| Scar | HUMAN OTC DRUG LABEL | 1 | 0363-3131 | GEL | 0.50 g | TOPICAL | OTC monograph final | 12 sections |
| ANBESOL COLD SORE THERAPY | HUMAN OTC DRUG LABEL | 4 | 0573-0246 | OINTMENT | 10 mg | TOPICAL | OTC monograph not final | 14 sections |
| Orajel Cold Sore Moisturelock | HUMAN OTC DRUG LABEL | 6 | 10237-761 | CREAM | 5 mg | TOPICAL | OTC monograph not final | 12 sections |
| TRIDERMA PROTECT AND HEAL NON- GREASY BARRIER | HUMAN OTC DRUG LABEL | 2 | 10738-061 | CREAM | 1.50 g | TOPICAL | OTC monograph final | 11 sections |
| TRIDERMA PROTECT AND HEAL NON- GREASY BARRIER | HUMAN OTC DRUG LABEL | 2 | 10738-061 | CREAM | 1.50 g | TOPICAL | OTC monograph final | 11 sections |
| TriDerma Stubborn Diaper Rash Relief | HUMAN OTC DRUG LABEL | 2 | 10738-068 | CREAM | 1.50 g | TOPICAL | OTC monograph final | 11 sections |
| TriDerma Stubborn Diaper Rash Relief | HUMAN OTC DRUG LABEL | 2 | 10738-068 | CREAM | 1.50 g | TOPICAL | OTC monograph final | 11 sections |
| SBS 40 | HUMAN OTC DRUG LABEL | 1 | 11084-040 | LOTION | 0.50 mL | TOPICAL | OTC monograph final | 22 sections |
| Cool Melon | HUMAN OTC DRUG LABEL | 1 | 11084-042 | CREAM | 0.50 mL | TOPICAL | OTC monograph final | 9 sections |
| SBS 41 Medicated Cream | HUMAN OTC DRUG LABEL | 1 | 11084-141 | CREAM | 5 mg | TOPICAL | OTC monograph final | 11 sections |
| SBS 40 | HUMAN OTC DRUG LABEL | 1 | 11084-240 | CREAM | 5 mg | TOPICAL | OTC monograph final | 11 sections |
| SBS 40 Medicated Cream | HUMAN OTC DRUG LABEL | 1 | 11084-241 | CREAM | 5 mg | TOPICAL | OTC monograph final | 11 sections |
| Sheffield Advanced Scar Gel | HUMAN OTC DRUG LABEL | 1 | 11527-725 | GEL | 5 mg | TOPICAL | OTC monograph final | 12 sections |
| Target Advanced Scar Gel | HUMAN OTC DRUG LABEL | 1 | 11673-725 | GEL | 5 mg | TOPICAL | OTC monograph final | 12 sections |
| Target Advanced Scar Gel | HUMAN OTC DRUG LABEL | 1 | 11673-725 | GEL | 5 mg | TOPICAL | OTC monograph final | 12 sections |
| Scar Care | HUMAN OTC DRUG LABEL | 1 | 11673-777 | GEL | 0.50 g | TOPICAL | OTC monograph final | 11 sections |
| Rite Aid Scar | HUMAN OTC DRUG LABEL | 1 | 11822-1297 | GEL | 0.50 g | TOPICAL | OTC monograph final | 7 sections |
| Rite Aid Advanced Scar Gel | HUMAN OTC DRUG LABEL | 1 | 11822-8214 | GEL | 5 mg | TOPICAL | OTC monograph final | 12 sections |
| SOOTHE Sensitive Skin Treatment | HUMAN OTC DRUG LABEL | 2 | 14222-2420 | LOTION | 0.50 g | TOPICAL | OTC monograph final | 12 sections |
| SOOTHE Sensitive Skin Treatment | HUMAN OTC DRUG LABEL | 2 | 14222-2420 | LOTION | 0.50 g | TOPICAL | OTC monograph final | 12 sections |
| Bodyglide anti chafe balm | HUMAN OTC DRUG LABEL | 1 | 15197-007 | STICK | 5 mg | TOPICAL | OTC MONOGRAPH FINAL | 16 sections |