allantoin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiepileptics, hydantoin derivatives 4268 97-59-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • allantoin
  • 5-Ureidohydantoin
  • allantion
  • allantol
  • glyoxyldiureid
  • glyoxyldiureide
  • glyoxylic diureide
A urea hydantoin that is found in URINE and PLANTS and is used in dermatological preparations.
  • Molecular weight: 158.12
  • Formula: C4H6N4O3
  • CLOGP: -1.91
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 113.32
  • ALOGS: -1.52
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 283.79 16.09 100 5684 24276 63458962
Methaemoglobinaemia 189.73 16.09 44 5740 2359 63480879
Creatinine renal clearance decreased 58.72 16.09 29 5755 16279 63466959
Sedation complication 57.08 16.09 27 5757 13795 63469443
Blood calcium decreased 50.67 16.09 31 5753 26420 63456818
Sedation 48.86 16.09 35 5749 38774 63444464
Orthostatic hypotension 44.12 16.09 32 5752 36128 63447110
Depressed level of consciousness 42.06 16.09 39 5745 62039 63421199
Product complaint 40.89 16.09 21 5763 12788 63470450
Cyanosis 32.82 16.09 20 5764 16915 63466323
Cognitive disorder 32.01 16.09 32 5752 55783 63427455
Constipation 31.87 16.09 66 5718 224877 63258361
Drug ineffective 27.95 16.09 176 5608 1044589 62438649
Balance disorder 24.29 16.09 34 5750 84388 63398850
Pustule 19.84 16.09 7 5777 1692 63481546
Paraesthesia oral 18.96 16.09 15 5769 19241 63463997
Alopecia 18.65 16.09 4 5780 337532 63145706
Superinfection 16.93 16.09 7 5777 2600 63480638

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood phosphorus increased 159.21 17.26 57 5919 7664 34943291
Methaemoglobinaemia 149.16 17.26 45 5931 3536 34947419
Appendicolith 145.91 17.26 55 5921 8546 34942409
Appendicitis 117.09 17.26 55 5921 14752 34936203
Ventricular fibrillation 102.38 17.26 58 5918 22896 34928059
Cardiogenic shock 89.34 17.26 56 5920 26562 34924393
Stress 87.44 17.26 58 5918 30289 34920666
Dry mouth 82.94 17.26 56 5920 30109 34920846
Ascites 77.62 17.26 64 5912 46507 34904448
Abdominal distension 74.57 17.26 69 5907 58423 34892532
Myasthenia gravis 68.16 17.26 30 5946 6910 34944045
Blood uric acid increased 61.74 17.26 31 5945 9593 34941362
Multiple organ dysfunction syndrome 60.73 17.26 70 5906 76496 34874459
Hyponatraemia 56.38 17.26 70 5906 82621 34868334
Vomiting 44.75 17.26 117 5859 247504 34703451
Abdominal pain 44.66 17.26 91 5885 163527 34787428
Blood cholesterol increased 37.92 17.26 30 5946 20513 34930442
Sepsis 36.70 17.26 85 5891 166476 34784479
Analgesic therapy 35.01 17.26 11 5965 987 34949968
Incorrect route of product administration 34.77 17.26 25 5951 14820 34936135
Sleep disorder therapy 34.74 17.26 11 5965 1012 34949943
Somnolence 34.14 17.26 65 5911 111051 34839904
Drug therapy 33.56 17.26 11 5965 1130 34949825
General physical health deterioration 31.07 17.26 68 5908 128201 34822754
Iron deficiency 30.64 17.26 16 5960 5365 34945590
Hyperphosphataemia 30.54 17.26 15 5961 4422 34946533
Product complaint 29.28 17.26 16 5960 5874 34945081
Condition aggravated 24.23 17.26 80 5896 192116 34758839
Nausea 24.00 17.26 118 5858 339790 34611165
Neuralgia 23.54 17.26 20 5956 15093 34935862
Bacterial infection 23.40 17.26 21 5955 17042 34933913
Hypophosphataemia 20.12 17.26 16 5960 11010 34939945
Haemolysis 19.80 17.26 14 5962 8080 34942875
Aspartate aminotransferase increased 18.78 17.26 38 5938 67745 34883210

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 321.47 14.97 86 10859 5471 79727972
Appendicolith 157.90 14.97 55 10890 8496 79724947
Blood phosphorus increased 155.02 14.97 57 10888 10290 79723153
Appendicitis 113.68 14.97 56 10889 20738 79712705
Ventricular fibrillation 101.54 14.97 60 10885 31866 79701577
Cardiogenic shock 77.31 14.97 56 10889 41858 79691585
Ascites 74.20 14.97 70 10875 75492 79657951
Myasthenia gravis 65.89 14.97 31 10914 10368 79723075
Blood uric acid increased 64.25 14.97 33 10912 13327 79720116
Stress 60.19 14.97 64 10881 79548 79653895
Abdominal distension 58.57 14.97 77 10868 119573 79613870
Dry mouth 54.91 14.97 64 10881 87955 79645488
Multiple organ dysfunction syndrome 52.19 14.97 73 10872 120173 79613270
Creatinine renal clearance decreased 48.38 14.97 31 10914 18971 79714472
Hyponatraemia 46.89 14.97 86 10859 177762 79555681
Sedation complication 46.04 14.97 28 10917 15641 79717802
Product complaint 44.83 14.97 26 10919 13323 79720120
Blood calcium decreased 44.35 14.97 36 10909 31783 79701660
Analgesic therapy 37.27 14.97 11 10934 998 79732445
Sleep disorder therapy 37.11 14.97 11 10934 1013 79732430
Abdominal pain 36.58 14.97 127 10818 389442 79344001
Sedation 36.20 14.97 40 10905 51855 79681588
Drug therapy 35.38 14.97 11 10934 1190 79732253
Hyperphosphataemia 34.32 14.97 17 10928 6359 79727084
Sepsis 32.72 14.97 96 10849 269332 79464111
Aspartate aminotransferase increased 30.35 14.97 62 10883 138579 79594864
Cyanosis 29.95 14.97 26 10919 25156 79708287
Depressed level of consciousness 29.67 14.97 50 10895 96602 79636841
Orthostatic hypotension 27.23 14.97 36 10909 56128 79677315
Vomiting 26.57 14.97 169 10776 665659 79067784
Iron deficiency 26.18 14.97 17 10928 10637 79722806
Somnolence 25.13 14.97 81 10864 238900 79494543
Alanine aminotransferase increased 23.75 14.97 62 10883 162508 79570935
Constipation 23.74 14.97 89 10856 282961 79450482
Bacterial infection 23.36 14.97 25 10920 31255 79702188
Incorrect route of product administration 22.77 14.97 26 10919 34903 79698540
Peripheral swelling 22.04 14.97 5 10940 269612 79463831
Haemolysis 18.92 14.97 15 10930 12797 79720646
Joint swelling 18.86 14.97 8 10937 288638 79444805
Arthralgia 17.87 14.97 32 10913 571771 79161672
Product dose omission issue 17.61 14.97 6 10939 247531 79485912
Cognitive disorder 17.38 14.97 33 10912 69893 79663550
Fatigue 16.97 14.97 68 10877 929659 78803784
Nausea 16.95 14.97 203 10742 956993 78776450
Hypophosphataemia 16.82 14.97 17 10928 19896 79713547
Pustule 15.86 14.97 7 10938 2018 79731425
Alopecia 15.79 14.97 6 10939 231349 79502094
Lymphocyte count decreased 15.22 14.97 25 10920 47264 79686179

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003879 Dermatologic Agents
CHEBI has role CHEBI:73336 wound-healing drug
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893
Seborrheic dermatitis indication 50563003 DOID:8741
Pityriasis simplex indication 200767005
Skin irritation indication 367466007
Itching of skin indication 418363000
Minor Skin Wound Pain indication
Folliculitis contraindication 13600006 DOID:4409
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Open wound contraindication 125643001
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Disease of liver contraindication 235856003 DOID:409
Porphyria contraindication 418470004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.71 acidic
pKa2 10.76 acidic
pKa3 11.46 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018613 VUID
N0000146926 NUI
D00121 KEGG_DRUG
4018613 VANDF
C0002083 UMLSCUI
CHEBI:15676 CHEBI
2AL PDB_CHEM_ID
CHEMBL593429 ChEMBL_ID
D000481 MESH_DESCRIPTOR_UI
DB11100 DRUGBANK_ID
344S277G0Z UNII
204 PUBCHEM_CID
508 RXNORM
4149 MMSL
72840 MMSL
002009 NDDF
395933009 SNOMEDCT_US
404834008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Mederma for Kids HUMAN OTC DRUG LABEL 1 0259-1101 GEL 10 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Mederma for Kids HUMAN OTC DRUG LABEL 1 0259-1101 GEL 10 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Mederma Advanced Scar HUMAN OTC DRUG LABEL 1 0259-1105 GEL 5 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Mederma Advanced Scar HUMAN OTC DRUG LABEL 1 0259-1105 GEL 5 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Cetaphil Baby Soothe and Protect Cream HUMAN OTC DRUG LABEL 1 0299-4103 CREAM 5 mg TOPICAL OTC monograph final 7 sections
Cetaphil Baby Soothe and Protect Cream HUMAN OTC DRUG LABEL 1 0299-4103 CREAM 5 mg TOPICAL OTC monograph final 7 sections
Cetaphil Soothing Gel Cream HUMAN OTC DRUG LABEL 1 0299-4105 CREAM 5 mg TOPICAL OTC monograph final 7 sections
Cetaphil Soothing Gel Cream HUMAN OTC DRUG LABEL 1 0299-4105 CREAM 5 mg TOPICAL OTC monograph final 7 sections
Walgreens Advanced Scar Gel HUMAN OTC DRUG LABEL 1 0363-2312 GEL 5 mg TOPICAL OTC monograph final 12 sections
Scar HUMAN OTC DRUG LABEL 1 0363-3131 GEL 0.50 g TOPICAL OTC monograph final 12 sections
ANBESOL COLD SORE THERAPY HUMAN OTC DRUG LABEL 4 0573-0246 OINTMENT 10 mg TOPICAL OTC monograph not final 14 sections
Orajel Cold Sore Moisturelock HUMAN OTC DRUG LABEL 6 10237-761 CREAM 5 mg TOPICAL OTC monograph not final 12 sections
TRIDERMA PROTECT AND HEAL NON- GREASY BARRIER HUMAN OTC DRUG LABEL 2 10738-061 CREAM 1.50 g TOPICAL OTC monograph final 11 sections
TRIDERMA PROTECT AND HEAL NON- GREASY BARRIER HUMAN OTC DRUG LABEL 2 10738-061 CREAM 1.50 g TOPICAL OTC monograph final 11 sections
TriDerma Stubborn Diaper Rash Relief HUMAN OTC DRUG LABEL 2 10738-068 CREAM 1.50 g TOPICAL OTC monograph final 11 sections
TriDerma Stubborn Diaper Rash Relief HUMAN OTC DRUG LABEL 2 10738-068 CREAM 1.50 g TOPICAL OTC monograph final 11 sections
SBS 40 HUMAN OTC DRUG LABEL 1 11084-040 LOTION 0.50 mL TOPICAL OTC monograph final 22 sections
Cool Melon HUMAN OTC DRUG LABEL 1 11084-042 CREAM 0.50 mL TOPICAL OTC monograph final 9 sections
SBS 41 Medicated Cream HUMAN OTC DRUG LABEL 1 11084-141 CREAM 5 mg TOPICAL OTC monograph final 11 sections
SBS 40 HUMAN OTC DRUG LABEL 1 11084-240 CREAM 5 mg TOPICAL OTC monograph final 11 sections
SBS 40 Medicated Cream HUMAN OTC DRUG LABEL 1 11084-241 CREAM 5 mg TOPICAL OTC monograph final 11 sections
Sheffield Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11527-725 GEL 5 mg TOPICAL OTC monograph final 12 sections
Target Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11673-725 GEL 5 mg TOPICAL OTC monograph final 12 sections
Target Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11673-725 GEL 5 mg TOPICAL OTC monograph final 12 sections
Scar Care HUMAN OTC DRUG LABEL 1 11673-777 GEL 0.50 g TOPICAL OTC monograph final 11 sections
Rite Aid Scar HUMAN OTC DRUG LABEL 1 11822-1297 GEL 0.50 g TOPICAL OTC monograph final 7 sections
Rite Aid Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11822-8214 GEL 5 mg TOPICAL OTC monograph final 12 sections
SOOTHE Sensitive Skin Treatment HUMAN OTC DRUG LABEL 2 14222-2420 LOTION 0.50 g TOPICAL OTC monograph final 12 sections
SOOTHE Sensitive Skin Treatment HUMAN OTC DRUG LABEL 2 14222-2420 LOTION 0.50 g TOPICAL OTC monograph final 12 sections
Bodyglide anti chafe balm HUMAN OTC DRUG LABEL 1 15197-007 STICK 5 mg TOPICAL OTC MONOGRAPH FINAL 16 sections