carbamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4264 57-13-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • urea
  • carbamide
  • carbamimidic acid
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
  • Molecular weight: 60.06
  • Formula: CH4N2O
  • CLOGP: -1.66
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 69.11
  • ALOGS: 0.84
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 5, 1966 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome 90.55 23.47 31 1563 20067 50583463
Platelet count decreased 25.86 23.47 23 1571 100703 50502827
Hypertension 25.12 23.47 32 1562 211171 50392359

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome 121.16 24.61 41 1584 14718 29558184
Decreased appetite 41.22 24.61 45 1580 145297 29427605
Hepatic encephalopathy 34.49 24.61 16 1609 13019 29559883
Hepatocellular carcinoma 29.65 24.61 12 1613 7026 29565876

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome 211.99 20.68 72 3146 28747 64466767
Decreased appetite 46.01 20.68 63 3155 281226 64214288
Platelet count decreased 44.46 20.68 48 3170 167663 64327851
Hepatic function abnormal 42.64 20.68 31 3187 64282 64431232
Hepatic encephalopathy 34.23 20.68 18 3200 21048 64474466
Hypertension 33.52 20.68 52 3166 259209 64236305
Diarrhoea 30.73 20.68 92 3126 722612 63772902
Hepatocellular carcinoma 28.69 20.68 12 3206 8391 64487123
Colon cancer 26.90 20.68 13 3205 12726 64482788
Dermatitis exfoliative 26.28 20.68 12 3206 10340 64485174
Enterocolitis 24.58 20.68 12 3206 12006 64483508
Blood bilirubin increased 21.74 20.68 20 3198 57533 64437981
Malignant neoplasm progression 21.03 20.68 27 3191 112844 64382670

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05BC02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTIONS
Solutions producing osmotic diuresis
ATC D02AE01 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
EMOLLIENTS AND PROTECTIVES
Carbamide products
ATC D02AE51 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
EMOLLIENTS AND PROTECTIVES
Carbamide products
CHEBI has role CHEBI:33287 fertilizers
CHEBI has role CHEBI:64577 dough improvers
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:83056 Daphnia magna metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Impacted cerumen indication 18070006
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Pityriasis versicolor indication 56454009 DOID:9060
Pityriasis simplex indication 200767005
Eruption of skin indication 271807003 DOID:0050486
Acne vulgaris off-label use 88616000
Hyperkeratosis off-label use 396228006
Rosacea off-label use 398909004 DOID:8881
Injury of ear contraindication 2999009
Otalgia contraindication 16001004
Chronic purulent otitis media contraindication 38394007 DOID:14247
Perforation of tympanic membrane contraindication 60442001
Procedure on ear contraindication 118891001
Infection of ear contraindication 129127001
Irritation of ear contraindication 162360008
Itching of ear contraindication 699392007
Ear Redness contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.96 acidic
pKa2 13.39 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Olfactory receptor 51E2 GPCR EC50 7.64 CHEMBL

External reference:

IDSource
4018430 VUID
N0000146756 NUI
D00023 KEGG_DRUG
4018430 VANDF
C0041942 UMLSCUI
CHEBI:16199 CHEBI
URE PDB_CHEM_ID
CHEMBL985 ChEMBL_ID
DB03904 DRUGBANK_ID
4539 IUPHAR_LIGAND_ID
1176 PUBCHEM_CID
11002 RXNORM
5656 MMSL
9476 MMSL
d04207 MMSL
002015 NDDF
002273 NDDF
16858004 SNOMEDCT_US
387092000 SNOMEDCT_US
D014508 MESH_DESCRIPTOR_UI
8W8T17847W UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Urea Cream 40% HUMAN PRESCRIPTION DRUG LABEL 1 0904-7167 CREAM 400 mg TOPICAL unapproved drug other 16 sections
Urea Cream 40% HUMAN PRESCRIPTION DRUG LABEL 1 16477-340 CREAM 400 mg TOPICAL unapproved drug other 15 sections
Urea Cream 41% HUMAN PRESCRIPTION DRUG LABEL 1 16477-341 CREAM 410 mg TOPICAL unapproved drug other 15 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42192-101 EMULSION 50 g TOPICAL unapproved drug other 14 sections
UREA HYDRATING TOPICAL HUMAN PRESCRIPTION DRUG LABEL 1 42192-115 AEROSOL, FOAM 35 g TOPICAL unapproved drug other 14 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42291-849 CREAM 40 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42291-849 CREAM 40 g TOPICAL unapproved drug other 13 sections
YouGreen F HUMAN OTC DRUG LABEL 1 42361-043 OINTMENT 7.50 g TOPICAL unapproved drug other 9 sections
CEM-Urea HUMAN PRESCRIPTION DRUG LABEL 1 42546-100 SOLUTION 0.45 mL TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42792-101 CREAM 390 mg TOPICAL unapproved drug other 9 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42808-202 CREAM 450 mg TOPICAL unapproved drug other 15 sections
Urea HUMAN PRESCRIPTION DRUG LABEL 1 42808-204 GEL 450 mg TOPICAL unapproved drug other 16 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 44523-617 CREAM 400 mg TOPICAL unapproved drug other 12 sections
Urea 47% Cream HUMAN PRESCRIPTION DRUG LABEL 1 50096-501 CREAM 470 mg TOPICAL unapproved drug other 11 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 52187-549 CREAM 470 mg TOPICAL unapproved drug other 11 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-308 CREAM 40 g TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-311 CREAM 39 g TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-312 LOTION 40 g TOPICAL unapproved drug other 12 sections
Urea 40 Percent HUMAN PRESCRIPTION DRUG LABEL 1 58657-487 CREAM 400 mg TOPICAL unapproved drug other 16 sections
Urea 41% HUMAN PRESCRIPTION DRUG LABEL 1 59088-489 CREAM 410 mg TOPICAL unapproved drug other 16 sections
Uremol HUMAN OTC DRUG LABEL 1 61344-452 LOTION 100 mg TOPICAL unapproved drug other 8 sections
Uremol 20% cream HUMAN OTC DRUG LABEL 1 61344-455 CREAM 200 mg TOPICAL unapproved drug other 7 sections
Urea 41 Percent HUMAN PRESCRIPTION DRUG LABEL 1 63629-1150 CREAM 410 mg TOPICAL unapproved drug other 17 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 63629-2036 CREAM 39 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 63629-2036 CREAM 39 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 63629-2037 CREAM 40 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 63629-2037 CREAM 40 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 63629-2038 CREAM 40 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 63629-2038 CREAM 40 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 63629-2039 CREAM 40 g TOPICAL unapproved drug other 13 sections