nitrogen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4251 7727-37-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitrogen
  • molecular nitrogen
  • nitrogen gas
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
  • Molecular weight: 28.01
  • Formula: N2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 47.58
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 872.16 12.04 1788 48551 513760 46121963
Pulmonary arterial hypertension 607.02 12.04 367 49972 25561 46610162
Oxygen saturation decreased 556.67 12.04 515 49824 68649 46567074
Pulmonary hypertension 459.52 12.04 350 49989 35643 46600080
Oxygen consumption increased 436.44 12.04 160 50179 3503 46632220
Right ventricular failure 395.20 12.04 235 50104 15858 46619865
Dyspnoea exertional 359.65 12.04 351 49988 49938 46585785
Fluid retention 357.08 12.04 352 49987 50694 46585029
Drug ineffective 266.77 12.04 206 50133 677632 45958091
Chronic obstructive pulmonary disease 259.07 12.04 315 50024 57318 46578405
Hypoxia 257.22 12.04 298 50041 51540 46584183
Oxygen therapy 209.73 12.04 78 50261 1779 46633944
Respiratory failure 196.08 12.04 360 49979 94456 46541267
Fluid overload 189.09 12.04 187 50152 26998 46608725
Transfusion 182.81 12.04 135 50204 13096 46622627
Rheumatoid arthritis 167.04 12.04 29 50310 240186 46395537
Nasal congestion 161.73 12.04 228 50111 47885 46587838
Pain in jaw 150.48 12.04 196 50143 38176 46597547
Pneumonia 143.59 12.04 790 49549 375530 46260193
Oedema peripheral 136.37 12.04 430 49909 159276 46476447
Acute respiratory failure 132.03 12.04 160 50179 28978 46606745
Toxicity to various agents 126.20 12.04 36 50303 211730 46423993
Oedema 122.91 12.04 242 50097 66829 46568894
Drug hypersensitivity 113.19 12.04 61 50278 243764 46391959
Cardiac failure 112.43 12.04 259 50080 79689 46556034
Concomitant disease aggravated 105.68 12.04 79 50260 7803 46627920
Cough 104.66 12.04 508 49831 229741 46405982
Pulmonary oedema 102.96 12.04 192 50147 50913 46584810
Pulmonary arterial pressure increased 101.42 12.04 56 50283 3276 46632447
Productive cough 100.26 12.04 189 50150 50526 46585197
Chest pain 98.80 12.04 414 49925 175910 46459813
Catheter site erythema 84.50 12.04 53 50286 3930 46631793
Catheter site pruritus 79.39 12.04 40 50299 1939 46633784
Neutropenia 77.07 12.04 29 50310 143175 46492548
Treatment failure 74.82 12.04 7 50332 93080 46542643
Scleroderma 72.54 12.04 51 50288 4578 46631145
Haemoptysis 72.01 12.04 113 50226 26076 46609647
Catheter management 71.68 12.04 42 50297 2753 46632970
Epistaxis 71.01 12.04 190 50149 64115 46571608
Headache 70.88 12.04 807 49532 477545 46158178
Lung transplant 70.35 12.04 42 50297 2850 46632873
Rash 68.25 12.04 180 50159 356332 46279391
Syncope 65.74 12.04 255 50084 104548 46531175
Brain natriuretic peptide increased 63.22 12.04 47 50292 4603 46631120
Off label use 61.72 12.04 207 50132 379634 46256089
Alopecia 60.13 12.04 52 50287 162362 46473361
Dependence on oxygen therapy 59.84 12.04 20 50319 329 46635394
Catheterisation cardiac 59.76 12.04 43 50296 4004 46631719
Hypercapnia 58.99 12.04 45 50294 4581 46631142
Condition aggravated 57.98 12.04 457 49882 244595 46391128
Blood pressure decreased 57.26 12.04 163 50176 56996 46578727
Drug abuse 56.03 12.04 3 50336 63405 46572318
Drug intolerance 54.53 12.04 47 50292 147002 46488721
Therapeutic product effect decreased 53.07 12.04 12 50327 82589 46553134
Device alarm issue 52.57 12.04 27 50312 1363 46634360
Injection site erythema 49.47 12.04 10 50329 74417 46561306
Cardiac failure congestive 47.88 12.04 211 50128 91539 46544184
Arthropathy 47.51 12.04 16 50323 84684 46551039
Exercise tolerance decreased 46.57 12.04 39 50300 4538 46631185
Injection site pain 46.52 12.04 29 50310 107123 46528600
Catheter site pain 46.29 12.04 36 50303 3770 46631953
Musculoskeletal stiffness 46.16 12.04 24 50315 97969 46537754
Palpitations 45.92 12.04 214 50125 95045 46540678
Intentional overdose 44.71 12.04 8 50331 64936 46570787
Unevaluable event 44.62 12.04 130 50209 46045 46589678
Suicide attempt 44.59 12.04 4 50335 55032 46580691
Joint swelling 44.39 12.04 69 50270 166004 46469719
Pulmonary veno-occlusive disease 44.08 12.04 21 50318 900 46634823
Hypotension 43.57 12.04 412 49927 232177 46403546
Pleural effusion 43.45 12.04 191 50148 82761 46552962
Cyanosis 42.64 12.04 68 50271 15903 46619820
Psoriasis 42.13 12.04 16 50323 78588 46557135
Pericardial effusion 41.80 12.04 88 50251 25455 46610268
Cor pulmonale 41.58 12.04 26 50313 1917 46633806
Transplant evaluation 40.98 12.04 21 50318 1055 46634668
Flushing 40.31 12.04 157 50182 64457 46571266
Arthralgia 40.10 12.04 230 50109 364373 46271350
Lung disorder 39.07 12.04 119 50220 43185 46592538
Chronic respiratory failure 39.00 12.04 24 50315 1720 46634003
Catheter site discharge 38.74 12.04 25 50314 1947 46633776
Dizziness 38.20 12.04 546 49793 339868 46295855
Dyspnoea at rest 37.39 12.04 31 50308 3557 46632166
Injection site reaction 37.39 12.04 4 50335 47845 46587878
Catheter site infection 37.38 12.04 35 50304 4718 46631005
Overdose 37.30 12.04 33 50306 101946 46533777
Pulmonary hypertensive crisis 36.93 12.04 12 50327 180 46635543
Orthopnoea 36.40 12.04 38 50301 5842 46629881
Device related infection 36.20 12.04 74 50265 20967 46614756
Pulmonary arterial pressure abnormal 36.14 12.04 15 50324 461 46635262
Catheter site rash 35.50 12.04 17 50322 737 46634986
Malaise 35.47 12.04 527 49812 330705 46305018
Pruritus 34.72 12.04 139 50200 242213 46393510
Chest discomfort 34.51 12.04 190 50149 90079 46545644
Therapeutic product effect incomplete 34.13 12.04 21 50318 78132 46557591
Febrile neutropenia 32.98 12.04 32 50307 94595 46541128
Infusion site pain 32.61 12.04 47 50292 10060 46625663
Hospitalisation 31.72 12.04 144 50195 63241 46572482
Oxygen saturation abnormal 31.53 12.04 25 50314 2693 46633030
Aspiration pleural cavity 31.20 12.04 16 50323 805 46634918
Suicidal ideation 31.01 12.04 11 50328 56371 46579352
Presyncope 30.85 12.04 76 50263 24378 46611345
Oxygen consumption 30.67 12.04 9 50330 94 46635629
Urticaria 30.52 12.04 50 50289 117842 46517881
Left ventricular failure 30.44 12.04 32 50307 4958 46630765
Peripheral swelling 30.05 12.04 281 50058 157790 46477933
Air embolism 30.03 12.04 11 50328 240 46635483
Respiratory distress 30.01 12.04 89 50250 31827 46603896
Nasal dryness 29.91 12.04 27 50312 3473 46632250
Pain 29.47 12.04 351 49988 476597 46159126
Glossodynia 29.41 12.04 6 50333 44367 46591356
Leukopenia 28.97 12.04 19 50320 68324 46567399
Exposure during pregnancy 28.86 12.04 45 50294 108167 46527556
Central venous catheterisation 28.68 12.04 21 50318 2009 46633714
Depression 28.02 12.04 92 50247 170012 46465711
Emphysema 27.61 12.04 41 50298 9013 46626710
Cardiac pacemaker insertion 26.74 12.04 26 50313 3673 46632050
Hand deformity 26.73 12.04 3 50336 34571 46601152
Cardiac failure acute 26.70 12.04 38 50301 8040 46627683
Paracentesis 26.36 12.04 15 50324 930 46634793
Device occlusion 25.87 12.04 32 50307 5913 46629810
Thermal burn 25.78 12.04 29 50310 4848 46630875
Therapy non-responder 25.66 12.04 100 50239 41052 46594671
Pulmonary congestion 25.40 12.04 52 50287 14747 46620976
Systemic lupus erythematosus 25.17 12.04 20 50319 65160 46570563
Device leakage 25.17 12.04 30 50309 5335 46630388
Maternal exposure during pregnancy 25.16 12.04 45 50294 102504 46533219
Stomatitis 25.09 12.04 22 50317 68275 46567448
Injection site pruritus 25.07 12.04 6 50333 39737 46595986
Catheter placement 25.01 12.04 19 50320 1922 46633801
Bronchitis 23.55 12.04 195 50144 105784 46529939
Infusion related reaction 23.43 12.04 46 50293 101162 46534561
Abdominal distension 23.25 12.04 147 50192 73204 46562519
N-terminal prohormone brain natriuretic peptide increased 22.60 12.04 17 50322 1694 46634029
Walking distance test abnormal 22.34 12.04 11 50328 507 46635216
Hypersensitivity 22.28 12.04 85 50254 150236 46485487
Rhinorrhoea 22.16 12.04 106 50233 47559 46588164
Injection site swelling 21.95 12.04 8 50331 40319 46595404
Death 21.83 12.04 494 49845 335054 46300669
Catheter site swelling 21.74 12.04 15 50324 1306 46634417
Rales 21.69 12.04 38 50301 9593 46626130
Wheezing 21.49 12.04 114 50225 53272 46582451
Catheter site scab 21.44 12.04 8 50331 184 46635539
Disease progression 21.37 12.04 170 50169 91130 46544593
Paraesthesia 21.12 12.04 61 50278 117376 46518347
Cardiac disorder 20.73 12.04 98 50241 43760 46591963
Pulmonary pain 20.70 12.04 16 50323 1660 46634063
Neuromuscular blockade 20.59 12.04 9 50330 315 46635408
Ascites 20.50 12.04 86 50253 36498 46599225
Nocturnal dyspnoea 20.31 12.04 13 50326 998 46634725
Multiple sclerosis relapse 20.30 12.04 10 50329 42115 46593608
Osteonecrosis of jaw 20.17 12.04 6 50333 34396 46601327
Product use in unapproved indication 20.07 12.04 42 50297 90231 46545492
Cardiac ablation 20.03 12.04 14 50325 1245 46634478
Coma 20.01 12.04 20 50319 58329 46577394
Sputum discoloured 19.73 12.04 43 50296 12735 46622988
Interstitial lung disease 19.57 12.04 112 50227 53837 46581886
Device connection issue 19.57 12.04 11 50328 666 46635057
Anaesthetic complication 19.56 12.04 16 50323 1801 46633922
Malignant neoplasm progression 19.28 12.04 25 50314 64901 46570822
Seizure 19.27 12.04 68 50271 122986 46512737
Atrial flutter 19.20 12.04 35 50304 9113 46626610
Concomitant disease progression 19.11 12.04 17 50322 2145 46633578
Pulmonary function test decreased 18.98 12.04 22 50317 3798 46631925
Gamma-glutamyltransferase increased 18.88 12.04 76 50263 31664 46604059
Drug interaction 18.75 12.04 135 50204 202959 46432764
Rhabdomyolysis 18.66 12.04 11 50328 41898 46593825
Stent placement 18.55 12.04 21 50318 3535 46632188
Blood cholesterol increased 18.54 12.04 10 50329 40003 46595720
Uterine hypotonus 18.53 12.04 6 50333 89 46635634
Hypoglycaemia 18.22 12.04 19 50320 54330 46581393
Infusion site infection 18.18 12.04 14 50325 1445 46634278
Weight increased 18.06 12.04 263 50076 164210 46471513
Injection site bruising 17.88 12.04 8 50331 35628 46600095
Bone marrow failure 17.72 12.04 5 50334 29664 46606059
Hyperandrogenism 17.50 12.04 6 50333 107 46635616
Hepatic enzyme increased 17.39 12.04 39 50300 81748 46553975
Hepatotoxicity 17.38 12.04 3 50336 25006 46610717
Cardiac arrest 17.31 12.04 161 50178 90238 46545485
Congestive hepatopathy 17.25 12.04 17 50322 2441 46633282
Localised oedema 16.98 12.04 24 50315 5045 46630678
Heart rate increased 16.81 12.04 138 50201 74653 46561070
Ventilation perfusion mismatch 16.81 12.04 7 50332 217 46635506
Blood iron decreased 16.74 12.04 37 50302 11060 46624663
Bladder agenesis 16.73 12.04 6 50333 123 46635600
Hyponatraemia 16.54 12.04 55 50284 101277 46534446
Cardioversion 16.46 12.04 12 50327 1140 46634583
Herpes zoster 16.45 12.04 30 50309 67842 46567881
Cloacal exstrophy 16.37 12.04 6 50333 131 46635592
Platelet transfusion 16.22 12.04 10 50329 719 46635004
Genitalia external ambiguous 16.12 12.04 6 50333 137 46635586
Wrong technique in product usage process 16.12 12.04 21 50318 54401 46581322
Rash maculo-papular 16.09 12.04 5 50334 27869 46607854
Abdominal cavity drainage 16.07 12.04 8 50331 378 46635345
Congenital ectopic bladder 16.04 12.04 5 50334 65 46635658
Argon plasma coagulation 16.03 12.04 4 50335 21 46635702
Right ventricular systolic pressure increased 16.01 12.04 9 50330 545 46635178
Cognitive disorder 15.97 12.04 10 50329 36873 46598850
Drug reaction with eosinophilia and systemic symptoms 15.85 12.04 6 50333 29542 46606181
Lung assist device therapy 15.77 12.04 5 50334 69 46635654
Neuropathy peripheral 15.77 12.04 48 50291 90845 46544878
Lipodystrophy acquired 15.68 12.04 13 50326 1492 46634231
Enlarged clitoris 15.61 12.04 6 50333 150 46635573
Tracheostomy 15.61 12.04 9 50330 572 46635151
Right ventricular dysfunction 15.58 12.04 13 50326 1505 46634218
Acute postoperative sialadenitis 15.58 12.04 4 50335 24 46635699
Thrombocytopenia 15.45 12.04 77 50262 126504 46509219
Cold burn 15.42 12.04 3 50336 3 46635720
Red blood cell sedimentation rate increased 15.36 12.04 3 50336 22886 46612837
Angioedema 15.28 12.04 12 50327 39330 46596393
Psychotic disorder 15.11 12.04 3 50336 22618 46613105
Gout 15.07 12.04 36 50303 11320 46624403
Subcutaneous emphysema 15.07 12.04 10 50329 817 46634906
Middle ear effusion 15.05 12.04 14 50325 1871 46633852
Meconium stain 15.01 12.04 6 50333 167 46635556
Blood pressure increased 14.92 12.04 78 50261 126588 46509135
Haematocrit decreased 14.90 12.04 76 50263 34981 46600742
Echocardiogram 14.81 12.04 4 50335 30 46635693
Hospice care 14.76 12.04 23 50316 5272 46630451
Terminal state 14.73 12.04 15 50324 2239 46633484
Jugular vein distension 14.54 12.04 10 50329 866 46634857
Osteoarthritis 14.51 12.04 28 50311 61997 46573726
Infusion site erythema 14.49 12.04 28 50311 7614 46628109
Mobility decreased 14.49 12.04 27 50312 60567 46575156
Pulmonary fibrosis 14.34 12.04 51 50288 20041 46615682
Iron deficiency anaemia 14.33 12.04 46 50293 17160 46618563
Hepatocellular injury 14.24 12.04 7 50332 29515 46606208
Respiratory tract infection 14.18 12.04 67 50272 29905 46605818
Right ventricular dilatation 14.16 12.04 10 50329 904 46634819
Catheter site haemorrhage 14.13 12.04 16 50323 2693 46633030
Hallucination 14.06 12.04 20 50319 49931 46585792
Breath sounds abnormal 14.05 12.04 28 50311 7787 46627936
Carbon dioxide increased 14.05 12.04 11 50328 1163 46634560
Gastrointestinal disorder congenital 14.01 12.04 5 50334 101 46635622
Dizziness exertional 13.97 12.04 7 50332 335 46635388
Rehabilitation therapy 13.90 12.04 11 50328 1181 46634542
Paradoxical embolism 13.88 12.04 4 50335 39 46635684
Oxygen consumption decreased 13.83 12.04 6 50333 206 46635517
Pulmonary haemorrhage 13.79 12.04 25 50314 6480 46629243
Idiopathic pulmonary fibrosis 13.75 12.04 12 50327 1476 46634247
Upper respiratory tract inflammation 13.73 12.04 16 50323 2779 46632944
Product use issue 13.70 12.04 54 50285 94590 46541133
Tethered cord syndrome 13.70 12.04 6 50333 211 46635512
Catheter site warmth 13.67 12.04 6 50333 212 46635511
Pulmonary artery banding 13.61 12.04 3 50336 8 46635715
PO2 decreased 13.52 12.04 12 50327 1510 46634213
Aspartate aminotransferase increased 13.51 12.04 137 50202 78563 46557160
Tachypnoea 13.47 12.04 40 50299 14311 46621412
Supraventricular tachycardia 13.43 12.04 38 50301 13232 46622491
Aggression 13.27 12.04 4 50335 22740 46612983
Congenital genital malformation 13.24 12.04 5 50334 119 46635604
Atrial fibrillation 13.13 12.04 170 50169 103420 46532303
Abdominal pain 13.13 12.04 172 50167 229859 46405864
Gastrointestinal arteriovenous malformation 13.03 12.04 8 50331 571 46635152
Injury 13.02 12.04 17 50322 44010 46591713
Increased bronchial secretion 12.91 12.04 12 50327 1602 46634121
Haemoglobin decreased 12.91 12.04 203 50136 128746 46506977
Urinary retention 12.84 12.04 6 50333 26055 46609668
Glossoptosis 12.83 12.04 4 50335 52 46635671
Therapy change 12.67 12.04 21 50318 5069 46630654
Accident 12.63 12.04 21 50318 5083 46630640
No adverse event 12.60 12.04 11 50328 34220 46601503
Emergency care 12.55 12.04 9 50330 833 46634890
Biopsy liver 12.53 12.04 7 50332 419 46635304
Therapeutic response decreased 12.42 12.04 17 50322 43128 46592595
C-reactive protein increased 12.40 12.04 28 50311 58562 46577161
Systemic scleroderma 12.33 12.04 9 50330 857 46634866
Hypozincaemia 12.31 12.04 3 50336 14 46635709
Hepatitis 12.29 12.04 10 50329 32205 46603518
Adverse drug reaction 12.25 12.04 18 50321 44344 46591379
Vascular cauterisation 12.25 12.04 4 50335 61 46635662
Gastrointestinal malformation 12.22 12.04 5 50334 148 46635575
Cardiomegaly 12.15 12.04 44 50295 17438 46618285
Lung squamous cell carcinoma stage I 12.14 12.04 3 50336 15 46635708
Vomiting 12.12 12.04 384 49955 452410 46183313

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 371.69 12.80 817 23112 332478 29596071
Oxygen saturation decreased 328.06 12.80 274 23655 43166 29885383
Pulmonary arterial hypertension 267.14 12.80 136 23793 9165 29919384
Hypoxia 190.01 12.80 212 23717 47642 29880907
Right ventricular failure 189.47 12.80 103 23826 7933 29920616
Chronic obstructive pulmonary disease 174.01 12.80 199 23730 45927 29882622
Oxygen consumption increased 168.91 12.80 56 23873 1232 29927317
Pulmonary hypertension 155.89 12.80 126 23803 18910 29909639
Fluid retention 113.57 12.80 119 23810 24879 29903670
Concomitant disease aggravated 110.61 12.80 62 23867 5067 29923482
Respiratory failure 110.08 12.80 246 23683 100396 29828153
Acute respiratory failure 94.82 12.80 110 23819 25740 29902809
Dyspnoea exertional 90.65 12.80 126 23803 35304 29893245
Pneumonia 86.27 12.80 507 23422 333799 29594750
Oxygen therapy 70.06 12.80 25 23904 690 29927859
Transfusion 68.82 12.80 53 23876 7408 29921141
Pain in jaw 60.86 12.80 61 23868 12095 29916454
Toxicity to various agents 59.30 12.80 34 23895 177149 29751400
Nasal congestion 58.24 12.80 73 23856 18493 29910056
Completed suicide 55.59 12.80 7 23922 99485 29829064
Cough 48.66 12.80 214 23715 125428 29803121
Pulmonary oedema 47.41 12.80 107 23822 43868 29884681
Pulmonary arterial pressure increased 46.46 12.80 21 23908 1083 29927466
Thermal burn 44.90 12.80 26 23903 2259 29926290
Fluid overload 43.09 12.80 64 23865 19028 29909521
Respiratory distress 40.99 12.80 85 23844 32887 29895662
Drug abuse 40.81 12.80 8 23921 82064 29846485
Brain natriuretic peptide increased 40.16 12.80 30 23899 4005 29924544
Cerebral artery thrombosis 39.19 12.80 15 23914 506 29928043
Hypercapnia 37.10 12.80 28 23901 3796 29924753
Oedema 36.07 12.80 95 23834 42898 29885651
Condition aggravated 35.87 12.80 210 23719 137656 29790893
Blood pressure decreased 33.54 12.80 98 23831 46977 29881572
Idiopathic pulmonary fibrosis 33.42 12.80 27 23902 4042 29924507
Pulmonary function test abnormal 33.18 12.80 18 23911 1378 29927171
Brain scan abnormal 32.58 12.80 14 23915 639 29927910
Catheter management 31.18 12.80 15 23914 892 29927657
Cor pulmonale 30.81 12.80 14 23915 731 29927818
Lung transplant 30.39 12.80 19 23910 1897 29926652
Catheter site erythema 30.08 12.80 16 23913 1178 29927371
Drug ineffective 28.42 12.80 158 23771 340229 29588320
Cardiac failure 27.75 12.80 136 23793 83282 29845267
Oedema peripheral 27.37 12.80 161 23768 105671 29822878
Mechanical ventilation 27.20 12.80 17 23912 1697 29926852
Neutropenia 26.02 12.80 39 23890 128501 29800048
Drug interaction 25.81 12.80 78 23851 199490 29729059
Neuromuscular block prolonged 25.54 12.80 10 23919 359 29928190
Pneumothorax 24.06 12.80 45 23884 16148 29912401
Pulmonary veno-occlusive disease 23.60 12.80 10 23919 441 29928108
Accident 23.57 12.80 21 23908 3592 29924957
Catheter removal 23.16 12.80 8 23921 200 29928349
Catheterisation cardiac 23.13 12.80 17 23912 2214 29926335
Rheumatoid arthritis 22.75 12.80 3 23926 41194 29887355
Air embolism 22.58 12.80 7 23922 123 29928426
Transplant evaluation 22.06 12.80 10 23919 519 29928030
Catheter placement 21.97 12.80 11 23918 714 29927835
Emphysema 21.90 12.80 32 23897 9370 29919179
Haemoptysis 21.46 12.80 64 23865 31014 29897535
Cyanosis 21.38 12.80 36 23893 11899 29916650
Catheter site haemorrhage 21.28 12.80 16 23913 2156 29926393
Subacute combined cord degeneration 21.24 12.80 7 23922 151 29928398
Carbon dioxide increased 21.04 12.80 12 23917 1013 29927536
Pulmonary fibrosis 20.97 12.80 42 23887 15848 29912701
Intentional overdose 20.70 12.80 4 23925 41477 29887072
Anaesthetic complication 20.57 12.80 12 23917 1057 29927492
Areflexia 20.15 12.80 17 23912 2702 29925847
Catheter site pruritus 20.05 12.80 8 23921 302 29928247
Acute kidney injury 19.74 12.80 133 23796 273709 29654840
Rotavirus infection 19.47 12.80 8 23921 326 29928223
Lung disorder 19.13 12.80 62 23867 31407 29897142
Hyperthermia malignant 19.07 12.80 14 23915 1820 29926729
Catheter site granuloma 19.00 12.80 4 23925 12 29928537
Accidental underdose 18.87 12.80 8 23921 353 29928196
Dyspnoea at rest 18.72 12.80 16 23913 2590 29925959
Catheter site discharge 18.56 12.80 9 23920 545 29928004
Catheter site pain 17.98 12.80 11 23918 1057 29927492
Ventilation perfusion mismatch 17.81 12.80 5 23924 61 29928488
Walking distance test abnormal 17.76 12.80 6 23923 140 29928409
Pulmonary capillary haemangiomatosis 17.55 12.80 4 23925 19 29928530
Aggression 17.51 12.80 4 23925 36903 29891646
Burns third degree 17.41 12.80 6 23923 149 29928400
Pulmonary hypertensive crisis 16.73 12.80 6 23923 168 29928381
Chronic respiratory failure 16.65 12.80 11 23918 1207 29927342
Thoracic cavity drainage 16.25 12.80 6 23923 183 29928366
Pulse pressure decreased 16.15 12.80 6 23923 186 29928363
Headache 16.09 12.80 219 23710 182087 29746462
Cardiac failure congestive 16.08 12.80 119 23810 84288 29844261
Anaesthetic complication cardiac 16.00 12.80 4 23925 30 29928519
Treatment failure 15.98 12.80 4 23925 34675 29893874
Catheter site warmth 15.88 12.80 4 23925 31 29928518
Leukopenia 15.78 12.80 13 23916 56146 29872403
PaO2/FiO2 ratio decreased 15.77 12.80 4 23925 32 29928517
Overdose 15.72 12.80 27 23902 84310 29844239
Myocardial infarction 15.58 12.80 50 23879 125575 29802974
Suicide attempt 15.49 12.80 5 23924 36692 29891857
Ventricular tachycardia 15.41 12.80 48 23881 23814 29904735
Pulmonary function test decreased 15.27 12.80 18 23911 4277 29924272
Peripheral swelling 15.18 12.80 92 23837 60982 29867567
Hyponatraemia 14.98 12.80 19 23910 67183 29861366
Epistaxis 14.59 12.80 82 23847 52899 29875650
Catheter site inflammation 14.48 12.80 6 23923 250 29928299
Pulmonary congestion 14.47 12.80 31 23898 12256 29916293
Apnoea 14.14 12.80 21 23908 6237 29922312
Complication associated with device 14.10 12.80 20 23909 5700 29922849
Barotrauma 14.02 12.80 4 23925 52 29928497
Respiratory acidosis 13.94 12.80 17 23912 4185 29924364
Productive cough 13.90 12.80 54 23875 29899 29898650
Confusional state 13.86 12.80 58 23871 134776 29793773
Subcutaneous emphysema 13.62 12.80 9 23920 988 29927561
Occupational exposure to product 13.45 12.80 6 23923 300 29928249
Interstitial lung disease 13.30 12.80 88 23841 60109 29868440
White blood cell count decreased 12.96 12.80 30 23899 83917 29844632

Pharmacologic Action:

SourceCodeDescription
ATC V03AN04 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Medical gases
CHEBI has role CHEBI:77974 food packaging gases
CHEBI has role CHEBI:78017 food propellants
CHEBI has role CHEBI:33937 macronutrients

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Persistent pulmonary hypertension of the newborn indication 233815004 DOID:13042
Methemoglobinemia contraindication 38959009 DOID:10783
Left heart failure contraindication 85232009
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019163 VUID
N0000147408 NUI
D00083 KEGG_DRUG
4019163 VANDF
C0028158 UMLSCUI
CHEBI:17997 CHEBI
HDZ PDB_CHEM_ID
TFH PDB_CHEM_ID
CHEMBL142438 ChEMBL_ID
D009584 MESH_DESCRIPTOR_UI
DB09152 DRUGBANK_ID
N762921K75 UNII
947 PUBCHEM_CID
7456 RXNORM
002515 NDDF
36012007 SNOMEDCT_US
767123001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10006-005 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10014-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10018-9502 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10167-400 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10218-102 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10221-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10252-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10304-601 GAS 999 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10412-0095 GAS 99.50 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10451-003 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-003 LIQUID 990 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-006 LIQUID 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-020 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-021 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-022 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-023 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10678-002 GAS 992 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10690-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10736-002 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
COMPRESSED GAS N.O.S. HUMAN PRESCRIPTION DRUG LABEL 3 10736-011 GAS 75.05 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10825-003 GAS 90 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10913-010 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10927-101 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10927-106 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10942-2000 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10942-2010 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 11023-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 11043-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGENCompressed, NF HUMAN PRESCRIPTION DRUG LABEL 1 11054-005 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections