nitrogen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4251 7727-37-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitrogen
  • molecular nitrogen
  • nitrogen gas
  • nitrogen, nf
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
  • Molecular weight: 28.01
  • Formula: N2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 47.58
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 929.48 12.29 1960 57641 659353 62770068
Pulmonary arterial hypertension 716.07 12.29 372 59229 22205 63407216
Oxygen saturation decreased 608.47 12.29 568 59033 88017 63341404
Pulmonary hypertension 532.81 12.29 367 59234 36756 63392665
Oxygen consumption increased 475.53 12.29 167 59434 3717 63425704
Right ventricular failure 454.45 12.29 251 59350 16937 63412484
Dyspnoea exertional 401.01 12.29 380 59221 59922 63369499
Fluid retention 379.61 12.29 367 59234 59319 63370102
Drug ineffective 366.80 12.29 270 59331 1044495 62384926
Respiratory failure 299.54 12.29 421 59180 101437 63327984
Hypoxia 293.72 12.29 320 59281 59472 63369949
Chronic obstructive pulmonary disease 293.26 12.29 327 59274 62359 63367062
Hypervolaemia 221.83 12.29 196 59405 28217 63401204
Pneumonia 221.72 12.29 931 58670 455836 62973585
Oxygen therapy 219.12 12.29 81 59520 2097 63427324
Transfusion 203.15 12.29 144 59457 15073 63414348
Contraindicated product administered 189.00 12.29 3 59598 217645 63211776
Pain in jaw 176.62 12.29 211 59390 43285 63386136
Nasal congestion 163.38 12.29 251 59350 65409 63364012
Oedema peripheral 160.37 12.29 465 59136 189046 63240375
Acute respiratory failure 159.65 12.29 179 59422 34306 63395115
Arthropathy 157.67 12.29 18 59583 234774 63194647
Treatment failure 157.14 12.29 7 59594 199036 63230385
Alopecia 152.64 12.29 63 59538 337473 63091948
Cough 149.75 12.29 607 58994 292136 63137285
Cardiac failure 145.83 12.29 283 59318 88859 63340562
Productive cough 141.20 12.29 230 59371 62978 63366443
Drug intolerance 138.91 12.29 58 59543 308603 63120818
Glossodynia 138.90 12.29 7 59594 178869 63250552
Rheumatoid arthritis 138.43 12.29 34 59567 253785 63175636
Therapeutic product effect decreased 137.01 12.29 12 59589 193175 63236246
Hand deformity 127.87 12.29 5 59596 159452 63269969
Joint swelling 123.02 12.29 78 59523 327588 63101833
Pulmonary oedema 121.64 12.29 199 59402 54674 63374747
Systemic lupus erythematosus 119.87 12.29 25 59576 208893 63220528
Pulmonary arterial pressure increased 118.97 12.29 61 59540 3534 63425887
Rash 117.99 12.29 217 59384 560654 62868767
Chest pain 113.67 12.29 452 59149 215507 63213914
Concomitant disease aggravated 109.69 12.29 81 59520 9031 63420390
Toxicity to various agents 107.18 12.29 49 59552 247201 63182220
Epistaxis 101.24 12.29 216 59385 72509 63356912
Drug hypersensitivity 100.99 12.29 86 59515 310601 63118820
Haemoptysis 99.97 12.29 129 59472 28597 63400824
Oedema 96.80 12.29 254 59347 97368 63332053
Catheter site erythema 95.63 12.29 56 59545 4220 63425201
Catheter site pruritus 94.23 12.29 44 59557 2076 63427345
Musculoskeletal stiffness 89.13 12.29 31 59570 184587 63244834
Lung transplant 89.07 12.29 48 59553 3080 63426341
Discomfort 88.18 12.29 24 59577 167350 63262071
Hepatic enzyme increased 86.27 12.29 41 59560 202287 63227134
Blood pressure decreased 85.79 12.29 189 59412 64833 63364588
Syncope 85.09 12.29 273 59328 117112 63312309
Hypercapnia 80.93 12.29 55 59546 5376 63424045
Pericarditis 79.14 12.29 14 59587 131565 63297856
Wound 77.80 12.29 28 59573 163235 63266186
Dependence on oxygen therapy 77.33 12.29 25 59576 427 63428994
Catheter management 77.21 12.29 43 59558 2944 63426477
Off label use 76.36 12.29 350 59251 674112 62755309
Cardiac failure congestive 76.32 12.29 225 59376 92208 63337213
Brain natriuretic peptide increased 75.80 12.29 52 59549 5161 63424260
Arthralgia 74.17 12.29 280 59321 569430 62859991
Psoriatic arthropathy 72.91 12.29 3 59598 91517 63337904
Headache 72.34 12.29 909 58692 632332 62797089
Hypersensitivity 71.94 12.29 102 59499 292583 63136838
Scleroderma 71.30 12.29 51 59550 5411 63424010
Hypotension 68.38 12.29 464 59137 272140 63157281
Infusion related reaction 66.02 12.29 80 59521 245441 63183980
Stomatitis 65.74 12.29 24 59577 138701 63290720
Death 65.51 12.29 586 59015 373795 63055626
Catheterisation cardiac 62.44 12.29 44 59557 4559 63424862
Product use issue 60.19 12.29 71 59530 220449 63208972
Device alarm issue 59.59 12.29 29 59572 1501 63427920
Pleural effusion 58.86 12.29 207 59394 93003 63336418
Palpitations 58.40 12.29 235 59366 112535 63316886
Pain 55.91 12.29 437 59164 740191 62689230
Pulmonary veno-occlusive disease 55.25 12.29 25 59576 1096 63428325
Neutropenia 54.92 12.29 50 59551 174955 63254466
Pericardial effusion 54.78 12.29 100 59501 29958 63399463
Cor pulmonale 54.27 12.29 30 59571 2024 63427397
Blister 54.25 12.29 27 59574 129787 63299634
Cyanosis 54.20 12.29 73 59528 16862 63412559
Therapeutic product effect incomplete 53.80 12.29 25 59576 125031 63304390
Flushing 52.90 12.29 173 59428 74914 63354507
Drug abuse 52.77 12.29 4 59597 72514 63356907
Dizziness 52.35 12.29 625 58976 429300 63000121
Catheter site pain 52.34 12.29 40 59561 4695 63424726
Unevaluable event 52.23 12.29 135 59466 51251 63378170
Maternal exposure during pregnancy 51.78 12.29 79 59522 219983 63209438
Blood cholesterol increased 50.42 12.29 13 59588 94019 63335402
Impaired healing 49.84 12.29 17 59584 102525 63326896
Chest discomfort 49.81 12.29 220 59381 109749 63319672
Malaise 48.58 12.29 600 59001 415354 63014067
Device related infection 48.03 12.29 82 59519 23310 63406111
Pruritus 48.01 12.29 176 59425 361277 63068144
Respiratory distress 47.41 12.29 101 59500 33850 63395571
Irritable bowel syndrome 46.94 12.29 10 59591 82402 63347019
Catheter site infection 46.75 12.29 38 59563 4876 63424545
Catheter site discharge 46.70 12.29 27 59574 1986 63427435
Orthopnoea 46.48 12.29 42 59559 6219 63423202
Dyspnoea at rest 46.28 12.29 35 59566 4044 63425377
Bronchitis 45.72 12.29 235 59366 124700 63304721
Exercise tolerance decreased 45.05 12.29 39 59562 5458 63423963
Intentional overdose 44.34 12.29 8 59593 74144 63355277
Exposure during pregnancy 43.60 12.29 49 59552 155498 63273923
Air embolism 42.67 12.29 14 59587 251 63429170
Infusion site pain 42.64 12.29 65 59536 16804 63412617
Respiratory tract infection 42.17 12.29 109 59492 41374 63388047
Left ventricular failure 41.93 12.29 38 59563 5649 63423772
Injection site erythema 41.81 12.29 13 59588 83161 63346260
Transplant evaluation 41.61 12.29 21 59580 1176 63428245
Catheter site rash 40.53 12.29 18 59583 755 63428666
Suicide attempt 40.03 12.29 5 59596 60913 63368508
Hospitalisation 39.88 12.29 172 59429 84909 63344512
Chronic respiratory failure 39.63 12.29 24 59577 1923 63427498
Injection site pain 38.48 12.29 39 59562 129761 63299660
Mobility decreased 37.54 12.29 35 59566 121124 63308297
Liver injury 37.35 12.29 6 59595 60514 63368907
Intentional product use issue 37.26 12.29 39 59562 127853 63301568
Pulmonary arterial pressure abnormal 36.78 12.29 15 59586 508 63428913
Urticaria 36.65 12.29 62 59539 165740 63263681
Lung disorder 36.51 12.29 135 59466 62126 63367295
Swelling 35.94 12.29 135 59466 275243 63154178
Atrial flutter 35.75 12.29 45 59556 9727 63419694
Pulmonary congestion 35.68 12.29 61 59540 17357 63412064
Oxygen saturation abnormal 35.08 12.29 28 59573 3501 63425920
Psoriasis 34.97 12.29 19 59582 86938 63342483
Abdominal distension 34.57 12.29 167 59434 86448 63342973
Nasal dryness 34.54 12.29 31 59570 4550 63424871
Cardiac disorder 33.93 12.29 115 59486 50701 63378720
Cardiac arrest 33.79 12.29 174 59427 92371 63337050
Atrial fibrillation 33.77 12.29 206 59395 116430 63312991
Presyncope 33.55 12.29 78 59523 27707 63401714
Injection site reaction 33.54 12.29 7 59594 58517 63370904
Ascites 32.51 12.29 98 59503 40630 63388791
Subcutaneous emphysema 32.49 12.29 16 59585 850 63428571
Aspiration pleural cavity 32.47 12.29 16 59585 851 63428570
Bladder agenesis 32.20 12.29 10 59591 149 63429272
Interstitial lung disease 32.02 12.29 129 59472 61779 63367642
Cardiac failure acute 31.93 12.29 42 59559 9481 63419940
Oxygen consumption 31.90 12.29 9 59592 94 63429327
Cloacal exstrophy 31.77 12.29 10 59591 156 63429265
Genitalia external ambiguous 31.77 12.29 10 59591 156 63429265
Emphysema 31.77 12.29 45 59556 10893 63418528
Pulmonary hypertensive crisis 31.71 12.29 12 59589 332 63429089
Congenital ectopic bladder 31.56 12.29 9 59592 98 63429323
Overdose 31.43 12.29 37 59564 115041 63314380
Catheter placement 31.37 12.29 22 59579 2262 63427159
Ill-defined disorder 31.25 12.29 19 59582 81736 63347685
Product use in unapproved indication 31.06 12.29 77 59524 179003 63250418
Abdominal discomfort 30.78 12.29 176 59425 320709 63108712
Oedematous kidney 30.54 12.29 9 59592 111 63429310
Febrile neutropenia 30.34 12.29 40 59561 118409 63311012
Anaemia 30.30 12.29 414 59187 293016 63136405
Meconium stain 29.89 12.29 10 59591 191 63429230
Cardiac pacemaker insertion 29.30 12.29 27 59574 4099 63425322
Thermal burn 29.03 12.29 32 59569 6014 63423407
Gastrointestinal disorder congenital 28.92 12.29 9 59592 135 63429286
Central venous catheterisation 28.82 12.29 22 59579 2577 63426844
Congenital genital malformation 28.21 12.29 9 59592 147 63429274
Knee arthroplasty 28.10 12.29 8 59593 54198 63375223
Device leakage 28.09 12.29 34 59567 7062 63422359
Rales 28.05 12.29 46 59555 12651 63416770
Sputum discoloured 28.05 12.29 53 59548 16294 63413127
Paracentesis 27.94 12.29 15 59586 955 63428466
Gamma-glutamyltransferase increased 27.27 12.29 82 59519 33949 63395472
Lipodystrophy acquired 27.26 12.29 17 59584 1435 63427986
Caudal regression syndrome 27.10 12.29 9 59592 168 63429253
Device occlusion 27.00 12.29 34 59567 7353 63422068
Cardiac ablation 26.91 12.29 17 59584 1468 63427953
Gastrointestinal malformation 26.56 12.29 9 59592 179 63429242
Tethered cord syndrome 26.51 12.29 10 59591 274 63429147
Pulmonary function test decreased 26.44 12.29 25 59576 3922 63425499
Fibromyalgia 26.39 12.29 22 59579 80398 63349023
Lower respiratory tract infection 26.11 12.29 53 59548 132254 63297167
Product dose omission issue 26.00 12.29 335 59266 233978 63195443
Walking distance test abnormal 25.78 12.29 12 59589 562 63428859
Red blood cell sedimentation rate increased 25.74 12.29 5 59596 43977 63385444
Heart rate increased 25.74 12.29 164 59437 94074 63335347
N-terminal prohormone brain natriuretic peptide increased 25.54 12.29 19 59582 2142 63427279
Catheter site scab 25.30 12.29 9 59592 208 63429213
Anaesthetic complication 24.89 12.29 18 59583 1942 63427479
Adverse drug reaction 24.72 12.29 23 59578 79691 63349730
Osteoarthritis 24.62 12.29 32 59569 95311 63334110
Pneumothorax 24.60 12.29 50 59551 16211 63413210
Haemoglobin decreased 24.47 12.29 226 59375 145259 63284162
Catheter site swelling 24.44 12.29 16 59585 1469 63427952
Congestive hepatopathy 24.37 12.29 21 59580 2921 63426500
Cognitive disorder 24.24 12.29 11 59590 55804 63373617
Infusion site erythema 24.05 12.29 41 59560 11638 63417783
Pancreatitis haemorrhagic 23.50 12.29 11 59590 522 63428899
Anal atresia 23.25 12.29 10 59591 388 63429033
Upper respiratory tract infection 23.16 12.29 144 59457 81903 63347518
Confusional state 23.00 12.29 129 59472 236251 63193170
Injury 22.87 12.29 21 59580 73226 63356195
Injection site pruritus 22.76 12.29 7 59594 45109 63384312
Gout 22.74 12.29 43 59558 13228 63416193
Oedematous pancreatitis 22.59 12.29 11 59590 570 63428851
Neuromuscular blockade 22.52 12.29 9 59592 289 63429132
Anencephaly 22.26 12.29 9 59592 298 63429123
C-reactive protein increased 22.25 12.29 34 59567 94673 63334748
Nocturnal dyspnoea 22.15 12.29 14 59587 1210 63428211
Neural tube defect 22.13 12.29 8 59593 194 63429227
Haematocrit decreased 21.98 12.29 84 59517 39256 63390165
Blood iron decreased 21.95 12.29 45 59556 14676 63414745
Pulmonary trichosporonosis 21.87 12.29 6 59595 56 63429365
Suicidal ideation 21.84 12.29 16 59585 62405 63367016
Paraesthesia 21.75 12.29 75 59526 156891 63272530
Rhinorrhoea 21.69 12.29 120 59481 65457 63363964
Type 2 diabetes mellitus 21.55 12.29 17 59584 63851 63365570
Depression 21.50 12.29 103 59498 196389 63233032
Concomitant disease progression 21.36 12.29 17 59584 2117 63427304
Condition aggravated 21.35 12.29 511 59090 401706 63027715
Device connection issue 21.03 12.29 11 59590 664 63428757
Carbon dioxide increased 20.90 12.29 14 59587 1336 63428085
Upper respiratory tract inflammation 20.88 12.29 18 59583 2505 63426916
Iron deficiency anaemia 20.84 12.29 53 59548 19916 63409505
Gastrointestinal disorder 20.80 12.29 59 59542 131180 63298241
Cardiomegaly 20.77 12.29 49 59552 17565 63411856
Bursitis 20.08 12.29 5 59596 37036 63392385
Localised oedema 20.05 12.29 25 59576 5353 63424068
Stent placement 20.01 12.29 21 59580 3734 63425687
Leukopenia 19.89 12.29 26 59575 77264 63352157
Aspartate aminotransferase increased 19.86 12.29 149 59452 90128 63339293
Disease progression 19.79 12.29 189 59412 122569 63306852
Injection site swelling 19.70 12.29 10 59591 47562 63381859
Infusion site infection 19.49 12.29 15 59586 1779 63427642
Supraventricular tachycardia 19.40 12.29 42 59559 14229 63415192
Right ventricular dysfunction 19.30 12.29 15 59586 1804 63427617
Sepsis 19.17 12.29 224 59377 152899 63276522
Meningomyelocele 19.05 12.29 10 59591 608 63428813
Multiple sclerosis relapse 18.90 12.29 11 59590 48467 63380954
Pulmonary artery banding 18.89 12.29 4 59597 10 63429411
Feeling abnormal 18.54 12.29 217 59384 148175 63281246
Sepsis neonatal 18.47 12.29 9 59592 467 63428954
Umbilical cord abnormality 18.39 12.29 10 59591 653 63428768
Hyperandrogenism 18.32 12.29 6 59595 107 63429314
Hip arthroplasty 18.31 12.29 11 59590 47635 63381786
Uterine hypotonus 18.27 12.29 6 59595 108 63429313
Tachypnoea 18.14 12.29 46 59555 17256 63412165
Hepatic function abnormal 18.10 12.29 76 59525 37066 63392355
Lung assist device therapy 18.06 12.29 6 59595 112 63429309
Pulmonary alveolar haemorrhage 17.88 12.29 22 59579 4646 63424775
Mediastinal effusion 17.33 12.29 5 59596 57 63429364
Right ventricular systolic pressure increased 17.29 12.29 9 59592 538 63428883
PO2 decreased 17.26 12.29 13 59588 1493 63427928
Oxygen consumption decreased 17.22 12.29 7 59594 235 63429186
Pulmonary haemorrhage 17.21 12.29 27 59574 7154 63422267
Bronchospasm 17.14 12.29 45 59556 17235 63412186
Exomphalos 17.13 12.29 9 59592 548 63428873
Cardioversion 16.99 12.29 12 59589 1248 63428173
Malignant neoplasm progression 16.97 12.29 32 59569 82089 63347332
Osteonecrosis of jaw 16.76 12.29 6 59595 35117 63394304
Argon plasma coagulation 16.58 12.29 4 59597 21 63429400
Platelet transfusion 16.57 12.29 10 59591 796 63428625
Abdominal cavity drainage 16.53 12.29 8 59593 409 63429012
Enlarged clitoris 16.35 12.29 6 59595 152 63429269
Terminal state 16.34 12.29 15 59586 2267 63427154
Compartment syndrome 16.33 12.29 15 59586 2269 63427152
Coma 16.21 12.29 22 59579 64342 63365079
Rehabilitation therapy 16.21 12.29 13 59588 1637 63427784
Inflammation 16.19 12.29 33 59568 82240 63347181
Neoplasm progression 16.10 12.29 7 59594 36421 63393000
Pulmonary artery dilatation 16.03 12.29 7 59594 282 63429139
Pulmonary pain 15.94 12.29 18 59583 3472 63425949
Idiopathic pulmonary fibrosis 15.92 12.29 12 59589 1380 63428041
Angioedema 15.89 12.29 13 59588 47952 63381469
Acute postoperative sialadenitis 15.85 12.29 4 59597 26 63429395
Cold burn 15.84 12.29 3 59598 3 63429418
Tachycardia 15.75 12.29 175 59426 117981 63311440
Echocardiogram 15.72 12.29 4 59597 27 63429394
Rhinocerebral mucormycosis 15.70 12.29 8 59593 457 63428964
Pneumonia bacterial 15.39 12.29 30 59571 9435 63419986
Pulmonary capillary haemangiomatosis 15.36 12.29 4 59597 30 63429391
Tracheostomy 15.33 12.29 9 59592 681 63428740
Blood urea increased 15.29 12.29 57 59544 26322 63403099
Neuropathy peripheral 15.28 12.29 55 59546 113612 63315809
Procedural hypotension 15.28 12.29 11 59590 1179 63428242
Middle ear effusion 15.22 12.29 15 59586 2476 63426945
Oral herpes 15.18 12.29 3 59598 26071 63403350
Accident 14.90 12.29 23 59578 6009 63423412
Head injury 14.90 12.29 58 59543 27338 63402083
Live birth 14.82 12.29 3 59598 25627 63403794
Rhonchi 14.80 12.29 15 59586 2561 63426860
Systemic scleroderma 14.77 12.29 10 59591 971 63428450
Jugular vein distension 14.73 12.29 10 59591 976 63428445
Paradoxical embolism 14.71 12.29 4 59597 36 63429385
Hypoglycaemia 14.66 12.29 21 59580 60044 63369377
Neutrophil count decreased 14.49 12.29 19 59582 56387 63373034
Prescribed overdose 14.42 12.29 7 59594 34146 63395275
Catheter site warmth 14.40 12.29 6 59595 215 63429206
Injection site bruising 14.33 12.29 11 59590 41899 63387522
Catheter site hypersensitivity 14.20 12.29 5 59596 112 63429309
Hepatitis 14.18 12.29 10 59591 39778 63389643
Hypertension 14.18 12.29 181 59420 279122 63150299
Dizziness exertional 14.02 12.29 7 59594 383 63429038
Choking sensation 14.02 12.29 17 59584 3537 63425884
Bone marrow failure 13.98 12.29 5 59596 29285 63400136
Hospice care 13.96 12.29 26 59575 7906 63421515
Limb injury 13.90 12.29 54 59547 25423 63403998
Gastrointestinal arteriovenous malformation 13.89 12.29 8 59593 584 63428837
Catheter site haemorrhage 13.87 12.29 16 59585 3159 63426262
Biopsy liver 13.84 12.29 7 59594 394 63429027
Distributive shock 13.80 12.29 11 59590 1372 63428049
Chills 13.80 12.29 165 59436 113213 63316208
Spina bifida 13.52 12.29 9 59592 850 63428571
Pregnancy 13.47 12.29 9 59592 36827 63392594
Breath sounds abnormal 13.46 12.29 31 59570 10942 63418479
Pneumomediastinum 13.44 12.29 11 59590 1425 63427996
Catheter site inflammation 13.42 12.29 9 59592 860 63428561
Increased bronchial secretion 13.41 12.29 12 59589 1754 63427667
Therapy change 13.39 12.29 22 59579 6059 63423362
Secretion discharge 13.33 12.29 33 59568 12198 63417223
Colitis ulcerative 13.25 12.29 4 59597 26087 63403334
Red blood cell count decreased 13.18 12.29 74 59527 40571 63388850
Joint range of motion decreased 13.16 12.29 7 59594 32421 63397000
Urinary retention 13.11 12.29 6 59595 30295 63399126
COVID-19 pneumonia 13.09 12.29 36 59565 14173 63415248
Disease recurrence 13.01 12.29 5 59596 28025 63401396
Sinus congestion 12.97 12.29 42 59559 18081 63411340
Mucosal inflammation 12.90 12.29 15 59586 46913 63382508
Foot deformity 12.88 12.29 5 59596 27848 63401573
Abdominal pain 12.82 12.29 196 59405 293260 63136161
Decreased activity 12.77 12.29 22 59579 6298 63423123
Hypozincaemia 12.73 12.29 3 59598 14 63429407
Decreased appetite 12.70 12.29 317 59284 250735 63178686
Right ventricular hypertrophy 12.62 12.29 8 59593 695 63428726
Mastitis bacterial 12.62 12.29 4 59597 64 63429357
Vascular cauterisation 12.56 12.29 4 59597 65 63429356
Catheter site erosion 12.56 12.29 4 59597 65 63429356
Menstrual discomfort 12.56 12.29 3 59598 15 63429406
Cardiac failure high output 12.54 12.29 6 59595 299 63429122
Apnoea 12.53 12.29 25 59576 7997 63421424
Respiration abnormal 12.52 12.29 22 59579 6395 63423026
Weight decreased 12.42 12.29 344 59257 276454 63152967
Lung squamous cell carcinoma stage I 12.39 12.29 3 59598 16 63429405

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 356.38 11.76 902 28895 375880 34551254
Oxygen saturation decreased 323.62 11.76 307 29490 53511 34873623
Pulmonary arterial hypertension 314.20 11.76 152 29645 8587 34918547
Hypoxia 236.12 11.76 262 29535 54833 34872301
Right ventricular failure 204.10 11.76 114 29683 8670 34918464
Oxygen consumption increased 169.90 11.76 58 29739 1308 34925826
Pulmonary hypertension 166.55 11.76 140 29657 20784 34906350
Respiratory failure 148.47 11.76 302 29495 108270 34818864
Chronic obstructive pulmonary disease 137.19 11.76 188 29609 48730 34878404
Pneumonia 118.09 11.76 614 29183 362013 34565121
Fluid retention 115.28 11.76 128 29669 26759 34900375
Concomitant disease aggravated 113.72 11.76 67 29730 5634 34921500
Acute respiratory failure 94.52 11.76 124 29673 30804 34896330
Dyspnoea exertional 83.79 11.76 140 29657 43139 34883995
Toxicity to various agents 71.57 11.76 41 29756 200321 34726813
Pain in jaw 68.15 11.76 69 29728 12971 34914163
Oxygen therapy 66.49 11.76 26 29771 870 34926264
Thermal burn 65.43 11.76 36 29761 2655 34924479
Transfusion 63.29 11.76 55 29742 8530 34918604
Completed suicide 61.97 11.76 6 29791 98162 34828972
Hypervolaemia 57.09 11.76 77 29720 19632 34907502
Drug abuse 55.41 11.76 9 29788 99087 34828047
Cerebral artery thrombosis 52.18 11.76 21 29776 759 34926375
Nasal congestion 52.02 11.76 80 29717 22977 34904157
Pulmonary oedema 50.92 11.76 120 29677 47409 34879725
Respiratory distress 50.75 11.76 101 29696 35564 34891570
Brain scan abnormal 49.73 11.76 21 29776 859 34926275
Pneumothorax 48.45 11.76 70 29727 19022 34908112
Cough 47.67 11.76 253 29544 149887 34777247
Pulmonary arterial pressure increased 45.43 11.76 22 29775 1243 34925891
Haemoptysis 40.37 11.76 91 29706 34915 34892219
Hypercapnia 39.15 11.76 31 29766 4224 34922910
Drug ineffective 38.70 11.76 230 29567 456521 34470613
Neutropenia 37.65 11.76 47 29750 156731 34770403
Oedema 37.10 11.76 104 29693 45637 34881497
Lung transplant 35.74 11.76 22 29775 2002 34925132
Brain natriuretic peptide increased 35.30 11.76 33 29764 5626 34921508
Idiopathic pulmonary fibrosis 35.24 11.76 27 29770 3507 34923627
Cardiac arrest 33.23 11.76 166 29631 95993 34831141
Blood pressure decreased 33.18 11.76 108 29689 51407 34875727
Areflexia 32.08 11.76 24 29773 3007 34924127
Catheter site erythema 32.01 11.76 18 29779 1385 34925749
COVID-19 pneumonia 30.32 11.76 53 29744 16914 34910220
Catheter management 29.38 11.76 15 29782 950 34926184
Chronic respiratory failure 29.03 11.76 17 29780 1412 34925722
Catheter placement 29.03 11.76 14 29783 784 34926350
Emphysema 28.78 11.76 38 29759 9487 34917647
Cor pulmonale 28.73 11.76 14 29783 802 34926332
Cardiac failure 28.39 11.76 153 29644 91095 34836039
Lung disorder 28.24 11.76 79 29718 34617 34892517
Catheter site haemorrhage 26.69 11.76 19 29778 2205 34924929
Mechanical ventilation 26.38 11.76 18 29779 1952 34925182
Catheter removal 26.15 11.76 9 29788 208 34926926
Condition aggravated 25.48 11.76 263 29534 191933 34735201
Oedema peripheral 25.39 11.76 182 29615 119630 34807504
Neuromuscular block prolonged 25.17 11.76 11 29786 490 34926644
Productive cough 25.00 11.76 80 29717 37733 34889401
Cyanosis 24.29 11.76 41 29756 12723 34914411
Pulmonary function test abnormal 23.98 11.76 19 29778 2591 34924543
Rhinocerebral mucormycosis 23.84 11.76 11 29786 557 34926577
Respiratory tract infection 22.45 11.76 51 29746 19661 34907473
Intentional overdose 22.21 11.76 5 29792 43669 34883465
Transplant evaluation 21.87 11.76 10 29787 496 34926638
Air embolism 21.48 11.76 7 29790 136 34926998
Catheterisation cardiac 21.46 11.76 18 29779 2659 34924475
Pulmonary veno-occlusive disease 21.34 11.76 10 29787 525 34926609
Subacute combined cord degeneration 21.06 11.76 7 29790 145 34926989
Rotavirus infection 20.69 11.76 9 29788 396 34926738
Interstitial lung disease 20.66 11.76 110 29687 65172 34861962
Pulmonary fibrosis 20.29 11.76 47 29750 18349 34908785
Headache 20.07 11.76 260 29537 200375 34726759
Ventilation perfusion mismatch 20.04 11.76 6 29791 87 34927047
Hypotension 20.03 11.76 282 29515 221367 34705767
Catheter site granuloma 19.85 11.76 5 29792 36 34927098
Catheter site pain 19.78 11.76 13 29784 1325 34925809
Carbon dioxide increased 19.72 11.76 12 29785 1069 34926065
Catheter site discharge 19.59 11.76 10 29787 633 34926501
PaO2/FiO2 ratio decreased 19.50 11.76 5 29792 39 34927095
SARS-CoV-2 viraemia 19.50 11.76 5 29792 39 34927095
Anaesthetic complication 19.33 11.76 12 29785 1108 34926026
Epistaxis 19.01 11.76 99 29698 58152 34868982
Treatment failure 18.99 11.76 8 29789 46689 34880445
Catheter site pruritus 18.88 11.76 8 29789 330 34926804
Burns third degree 18.53 11.76 7 29790 213 34926921
Pulmonary function test decreased 18.47 11.76 22 29775 4953 34922181
Rheumatoid arthritis 18.23 11.76 5 29792 38233 34888901
Accident 18.21 11.76 22 29775 5025 34922109
Tachypnoea 18.21 11.76 45 29752 18307 34908827
Hyperthermia malignant 18.21 11.76 15 29782 2162 34924972
Catheter site warmth 18.13 11.76 5 29792 53 34927081
Abdominal pain 18.01 11.76 75 29722 163543 34763591
Bradycardia 18.00 11.76 118 29679 75300 34851834
White blood cell count decreased 17.73 11.76 34 29763 95411 34831723
Cardiac failure congestive 17.34 11.76 126 29671 83144 34843990
Pulmonary congestion 17.24 11.76 37 29760 13728 34913406
Pneumomediastinum 17.11 11.76 15 29782 2352 34924782
Therapeutic product effect incomplete 17.08 11.76 11 29786 50530 34876604
Aggression 16.96 11.76 6 29791 38958 34888176
Drug interaction 16.88 11.76 118 29679 225828 34701306
Pulmonary alveolar haemorrhage 16.84 11.76 26 29771 7486 34919648
Thyroglobulin increased 16.81 11.76 4 29793 22 34927112
Hyponatraemia 16.67 11.76 28 29769 82663 34844471
Respiratory acidosis 16.59 11.76 21 29776 5029 34922105
Confusional state 16.54 11.76 65 29732 144095 34783039
Pulmonary hypertensive crisis 16.38 11.76 6 29791 167 34926967
Hypocapnia 16.32 11.76 6 29791 169 34926965
Apnoea 16.27 11.76 24 29773 6640 34920494
Walking distance test abnormal 16.06 11.76 6 29791 177 34926957
Anaesthetic complication cardiac 15.86 11.76 4 29793 29 34927105
Superinfection fungal 15.86 11.76 4 29793 29 34927105
Pulse pressure decreased 15.84 11.76 6 29791 184 34926950
Thrombocytopenia 15.76 11.76 74 29723 156173 34770961
Alkalosis hypochloraemic 15.74 11.76 7 29790 325 34926809
Accidental underdose 15.68 11.76 8 29789 506 34926628
Ventricular tachycardia 15.58 11.76 54 29743 26525 34900609
Thoracic cavity drainage 15.51 11.76 6 29791 195 34926939
Barotrauma 15.19 11.76 4 29793 35 34927099
Infusion site vesicles 14.96 11.76 6 29791 215 34926919
Dependence on oxygen therapy 14.96 11.76 6 29791 215 34926919
Leukopenia 14.90 11.76 19 29778 62837 34864297
Pulseless electrical activity 14.84 11.76 24 29773 7187 34919947
Respiratory disorder 14.83 11.76 43 29754 19221 34907913
Catheter site inflammation 14.83 11.76 6 29791 220 34926914
Acute kidney injury 14.66 11.76 178 29619 304810 34622324
Bronchopulmonary aspergillosis 14.60 11.76 36 29761 14623 34912511
Pulmonary haemorrhage 14.43 11.76 29 29768 10275 34916859
Aspartate aminotransferase increased 14.36 11.76 103 29694 67680 34859454
Acute right ventricular failure 14.23 11.76 5 29792 123 34927011
Hemiplegia 14.07 11.76 23 29774 6949 34920185
Device intolerance 14.05 11.76 3 29794 9 34927125
Coma 14.05 11.76 11 29786 45667 34881467
Syncope 13.98 11.76 129 29668 91322 34835812
Suicide attempt 13.93 11.76 8 29789 39108 34888026
Complication associated with device 13.77 11.76 21 29776 5985 34921149
Mucosal inflammation 13.61 11.76 8 29789 38614 34888520
Haemodynamic instability 13.57 11.76 27 29770 9496 34917638
Myotonic dystrophy 13.49 11.76 5 29792 144 34926990
Rash maculo-papular 13.05 11.76 4 29793 28447 34898687
Electrocardiogram ST segment elevation 12.98 11.76 19 29778 5219 34921915
Device related infection 12.81 11.76 38 29759 17199 34909935
Procedural complication 12.80 11.76 17 29780 4266 34922868
Dyspnoea at rest 12.71 11.76 16 29781 3812 34923322
Febrile neutropenia 12.54 11.76 67 29730 136782 34790352
Therapeutic product effect decreased 12.53 11.76 7 29790 34736 34892398
Thoracotomy 12.51 11.76 4 29793 73 34927061
Myocardial infarction 12.41 11.76 57 29740 121028 34806106
Delayed recovery from anaesthesia 12.37 11.76 8 29789 793 34926341
Cardiac assistance device user 12.11 11.76 3 29794 20 34927114
Alopecia 11.96 11.76 3 29794 24352 34902782

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 1025.51 11.01 2430 74881 854595 78812482
Pulmonary arterial hypertension 944.42 11.01 488 76823 27878 79639199
Oxygen saturation decreased 779.06 11.01 782 76529 128265 79538812
Pulmonary hypertension 606.65 11.01 445 76866 47635 79619442
Oxygen consumption increased 579.86 11.01 208 77103 4771 79662306
Right ventricular failure 564.87 11.01 326 76985 23171 79643906
Fluid retention 474.94 11.01 452 76859 69357 79597720
Hypoxia 451.35 11.01 528 76783 102715 79564362
Dyspnoea exertional 410.36 11.01 463 76848 86610 79580467
Respiratory failure 308.35 11.01 595 76716 180316 79486761
Chronic obstructive pulmonary disease 299.31 11.01 391 76920 85028 79582049
Hypervolaemia 255.83 11.01 258 77053 42432 79624645
Drug ineffective 250.20 11.01 416 76895 1080497 78586580
Pain in jaw 246.11 11.01 262 77049 45889 79621188
Transfusion 243.43 11.01 186 77125 21144 79645933
Pneumonia 238.00 11.01 1263 76048 658983 79008094
Oxygen therapy 217.72 11.01 87 77224 2703 79664374
Acute respiratory failure 210.77 11.01 274 77037 59267 79607810
Completed suicide 210.53 11.01 6 77305 245761 79421316
Toxicity to various agents 198.91 11.01 80 77231 421460 79245617
Concomitant disease aggravated 189.22 11.01 132 77179 13035 79654042
Nasal congestion 185.25 11.01 294 77017 76258 79590819
Oedema peripheral 160.94 11.01 574 76737 251714 79415363
Pulmonary oedema 146.17 11.01 287 77024 87967 79579110
Cough 145.10 11.01 721 76590 366068 79301009
Pulmonary arterial pressure increased 133.43 11.01 72 77239 4483 79662594
Catheter site erythema 126.66 11.01 73 77238 5167 79661910
Oedema 124.17 11.01 323 76988 119257 79547820
Contraindicated product administered 121.27 11.01 8 77303 157530 79509547
Therapeutic product effect decreased 118.63 11.01 11 77300 163852 79503225
Cardiac failure 117.85 11.01 374 76937 154468 79512609
Drug abuse 117.57 11.01 11 77300 162680 79504397
Treatment failure 114.44 11.01 15 77296 170471 79496606
Rheumatoid arthritis 113.18 11.01 31 77280 208439 79458638
Catheter site pruritus 111.06 11.01 51 77260 2240 79664837
Productive cough 110.16 11.01 256 77055 88075 79579002
Brain natriuretic peptide increased 109.05 11.01 81 77230 8819 79658258
Arthropathy 106.73 11.01 21 77290 177090 79489987
Lung transplant 106.16 11.01 62 77249 4499 79662578
Haemoptysis 104.94 11.01 192 77119 55807 79611270
Blood pressure decreased 99.51 11.01 265 77046 99201 79567876
Chest pain 98.40 11.01 536 76775 281768 79385309
Neutropenia 98.03 11.01 81 77230 287629 79379448
Drug intolerance 96.81 11.01 69 77242 264050 79403027
Hypercapnia 95.58 11.01 75 77236 8860 79658217
Alopecia 93.59 11.01 54 77257 231301 79435776
Headache 93.00 11.01 1005 76306 652767 79014310
Catheter management 88.46 11.01 51 77260 3612 79663465
Epistaxis 86.32 11.01 271 77040 111244 79555833
Catheterisation cardiac 83.64 11.01 58 77253 5670 79661407
Respiratory distress 78.19 11.01 174 77137 58165 79608912
Rash 78.01 11.01 293 77018 578065 79089012
Hand deformity 77.88 11.01 6 77305 103913 79563164
Joint swelling 77.14 11.01 100 77211 288546 79378531
Drug hypersensitivity 76.40 11.01 107 77204 298809 79368268
Syncope 75.99 11.01 360 76951 179089 79487988
Cyanosis 71.18 11.01 104 77207 25078 79641999
Thermal burn 69.97 11.01 57 77254 7103 79659974
Glossodynia 69.55 11.01 9 77302 103328 79563749
Scleroderma 69.42 11.01 51 77260 5459 79661618
Pulmonary veno-occlusive disease 68.53 11.01 33 77278 1615 79665462
Catheter site pain 68.11 11.01 50 77261 5346 79661731
Dependence on oxygen therapy 67.40 11.01 24 77287 538 79666539
Intentional overdose 67.21 11.01 11 77300 105949 79561128
Musculoskeletal stiffness 66.39 11.01 44 77267 174964 79492113
Pericarditis 65.71 11.01 11 77300 104225 79562852
Stomatitis 65.66 11.01 30 77281 146727 79520350
Hypotension 64.84 11.01 682 76629 439635 79227442
Catheter site discharge 62.05 11.01 35 77276 2377 79664700
Unevaluable event 61.66 11.01 154 77157 55431 79611646
Hepatic enzyme increased 61.43 11.01 52 77259 182558 79484519
Device alarm issue 61.13 11.01 33 77278 2056 79665021
Air embolism 60.93 11.01 21 77290 426 79666651
Cardiac failure congestive 58.33 11.01 283 77028 142119 79524958
Therapeutic product effect incomplete 57.34 11.01 33 77278 141612 79525465
Flushing 57.16 11.01 202 77109 88066 79579011
Systemic lupus erythematosus 55.40 11.01 24 77287 121125 79545952
Catheter placement 55.27 11.01 35 77276 2939 79664138
Device related infection 54.90 11.01 110 77201 34184 79632893
Chronic respiratory failure 54.75 11.01 35 77276 2987 79664090
Arthralgia 54.56 11.01 328 76983 571475 79095602
Catheter site infection 53.93 11.01 48 77263 6747 79660330
Pleural effusion 53.38 11.01 280 77031 144982 79522095
Pulmonary hypertensive crisis 53.33 11.01 18 77293 342 79666735
Pericardial effusion 52.23 11.01 129 77182 46108 79620969
Emphysema 51.50 11.01 71 77240 16229 79650848
Hypersensitivity 51.38 11.01 111 77200 262128 79404949
Transplant evaluation 50.19 11.01 27 77284 1670 79665407
Off label use 49.80 11.01 602 76709 906613 78760464
Pneumothorax 49.17 11.01 94 77217 28229 79638848
Palpitations 48.57 11.01 247 77064 126363 79540714
Infusion related reaction 48.03 11.01 94 77217 230143 79436934
Intentional product use issue 47.95 11.01 46 77265 152066 79515011
Catheter site rash 47.55 11.01 22 77289 983 79666094
Cor pulmonale 45.44 11.01 28 77283 2240 79664837
Overdose 45.01 11.01 68 77243 184138 79482939
Dizziness 44.89 11.01 738 76573 525703 79141374
Cardiac arrest 44.76 11.01 303 77008 171793 79495284
Discomfort 44.45 11.01 34 77277 125583 79541494
Blood cholesterol increased 44.39 11.01 13 77298 83707 79583370
Condition aggravated 44.02 11.01 706 76605 500418 79166659
Suicide attempt 43.74 11.01 13 77298 82919 79584158
Infusion site pain 43.67 11.01 61 77250 14115 79652962
Dyspnoea at rest 43.48 11.01 44 77267 7258 79659819
Pulmonary congestion 43.47 11.01 87 77224 27013 79640064
Confusional state 42.84 11.01 161 77150 317836 79349241
Helicobacter infection 42.53 11.01 8 77303 69696 79597381
Lung disorder 41.95 11.01 172 77139 80385 79586692
Febrile neutropenia 41.83 11.01 102 77209 230897 79436180
Injection site pain 41.23 11.01 39 77272 129799 79537278
Brain scan abnormal 40.55 11.01 21 77290 1202 79665875
Pulmonary function test decreased 40.06 11.01 43 77268 7594 79659483
Orthopnoea 39.81 11.01 49 77262 10024 79657053
Mobility decreased 39.62 11.01 36 77275 122139 79544938
Anaesthetic complication 39.53 11.01 28 77283 2831 79664246
Cerebral artery thrombosis 39.51 11.01 20 77291 1091 79665986
Respiratory tract infection 38.27 11.01 119 77192 48570 79618507
Pain 38.17 11.01 468 76843 703334 78963743
Cardiac failure acute 38.13 11.01 67 77244 18862 79648215
Nasal dryness 37.74 11.01 33 77278 4530 79662547
Walking distance test abnormal 37.57 11.01 17 77294 721 79666356
Rhinocerebral mucormycosis 37.49 11.01 19 77292 1039 79666038
Pruritus 37.26 11.01 227 77084 394421 79272656
Urticaria 36.59 11.01 78 77233 185123 79481954
Catheter site haemorrhage 36.41 11.01 34 77277 5083 79661994
Death 36.37 11.01 760 76551 565754 79101323
Irritable bowel syndrome 36.20 11.01 8 77303 62233 79604844
Impaired healing 36.07 11.01 20 77291 87635 79579442
Oxygen saturation abnormal 35.63 11.01 32 77279 4550 79662527
Hospitalisation 35.54 11.01 183 77128 94053 79573024
Left ventricular failure 35.30 11.01 45 77266 9536 79657541
Malaise 34.70 11.01 667 76644 489202 79177875
Coma 34.65 11.01 28 77283 100621 79566456
Exercise tolerance decreased 34.05 11.01 43 77268 9028 79658049
Injection site reaction 34.04 11.01 6 77305 54779 79612298
Abdominal pain 33.75 11.01 230 77081 389339 79277738
Device occlusion 33.52 11.01 49 77262 11817 79655260
Chest discomfort 33.50 11.01 239 77072 137805 79529272
Injection site erythema 33.42 11.01 17 77294 78180 79588897
Psoriasis 33.32 11.01 23 77288 89564 79577513
Mucosal inflammation 32.95 11.01 16 77295 75564 79591513
Neuromuscular block prolonged 32.19 11.01 17 77294 1013 79666064
Hypoglycaemia 31.69 11.01 31 77280 101563 79565514
Pulmonary arterial pressure abnormal 31.28 11.01 15 77296 727 79666350
Blister 31.26 11.01 42 77269 119434 79547643
Subcutaneous emphysema 30.59 11.01 20 77291 1774 79665303
Suicidal ideation 30.58 11.01 18 77293 76322 79590755
Pulmonary alveolar haemorrhage 30.48 11.01 46 77265 11411 79655666
Abdominal distension 30.10 11.01 209 77102 119441 79547636
Idiopathic pulmonary fibrosis 29.90 11.01 28 77283 4200 79662877
Catheter removal 29.82 11.01 14 77297 647 79666430
Central venous catheterisation 29.67 11.01 25 77286 3264 79663813
Pulseless electrical activity 29.67 11.01 51 77260 14109 79652968
Leukopenia 29.44 11.01 42 77269 116471 79550606
Wound 29.23 11.01 42 77269 116137 79550940
Interstitial lung disease 29.11 11.01 198 77113 112402 79554675
COVID-19 pneumonia 28.96 11.01 77 77234 28772 79638305
N-terminal prohormone brain natriuretic peptide increased 28.95 11.01 29 77282 4726 79662351
Carbon dioxide increased 28.82 11.01 21 77290 2219 79664858
Malignant neoplasm progression 28.79 11.01 55 77256 135935 79531142
Cardiac ablation 28.72 11.01 21 77290 2232 79664845
Tachypnoea 28.64 11.01 82 77229 31981 79635096
Concomitant disease progression 28.49 11.01 25 77286 3448 79663629
Catheter site scab 28.05 11.01 10 77301 225 79666852
Paracentesis 27.96 11.01 17 77294 1328 79665749
Bronchitis 27.63 11.01 219 77092 130425 79536652
Aspiration pleural cavity 27.50 11.01 18 77293 1599 79665478
Acute kidney injury 27.50 11.01 347 76964 519057 79148020
Cardiac pacemaker insertion 27.45 11.01 31 77280 5791 79661286
Stevens-Johnson syndrome 27.36 11.01 3 77308 39163 79627914
Hyponatraemia 27.35 11.01 85 77226 177763 79489314
Cognitive disorder 27.29 11.01 17 77294 69909 79597168
Aggression 26.85 11.01 8 77303 50950 79616127
Catheter site warmth 26.73 11.01 10 77301 259 79666818
Device connection issue 26.40 11.01 15 77296 1033 79666044
Congestive hepatopathy 26.35 11.01 27 77284 4520 79662557
Osteonecrosis of jaw 26.29 11.01 5 77306 43221 79623856
Atrial flutter 26.20 11.01 62 77249 21563 79645514
Drug interaction 26.04 11.01 267 77044 414916 79252161
Depression 25.89 11.01 115 77196 216675 79450402
Neoplasm progression 25.66 11.01 9 77302 51673 79615404
Neutrophil count decreased 25.64 11.01 32 77279 93927 79573150
Injection site pruritus 25.48 11.01 5 77306 42278 79624799
Drug resistance 25.42 11.01 5 77306 42208 79624869
Neuromuscular blockade 25.29 11.01 12 77299 568 79666509
Catheter site swelling 25.22 11.01 18 77293 1842 79665235
Cardiomegaly 25.12 11.01 69 77242 26283 79640794
Oedematous kidney 25.02 11.01 9 77302 208 79666869
Nocturnal dyspnoea 25.01 11.01 17 77294 1609 79665468
Sputum discoloured 24.91 11.01 61 77250 21682 79645395
Product use in unapproved indication 24.66 11.01 142 77169 250217 79416860
Liver injury 24.65 11.01 12 77299 56602 79610475
Fibromyalgia 24.62 11.01 16 77295 64324 79602753
Red blood cell sedimentation rate increased 24.60 11.01 7 77304 45935 79621142
Atrial fibrillation 24.28 11.01 296 77015 197590 79469487
Heart rate increased 24.25 11.01 200 77111 120524 79546553
Ventilation perfusion mismatch 24.17 11.01 12 77299 628 79666449
Presyncope 24.07 11.01 91 77220 40963 79626114
Hepatitis 23.98 11.01 12 77299 55715 79611362
Hyperthermia malignant 23.93 11.01 21 77290 2896 79664181
Acute right ventricular failure 23.88 11.01 10 77301 351 79666726
Right ventricular dysfunction 23.71 11.01 20 77291 2615 79664462
Tracheostomy 23.71 11.01 15 77296 1257 79665820
Hypertension 23.67 11.01 206 77105 330786 79336291
Peripheral swelling 23.66 11.01 380 76931 269237 79397840
Infusion site infection 23.61 11.01 17 77294 1764 79665313
Accidental underdose 23.51 11.01 13 77298 849 79666228
Pneumomediastinum 23.50 11.01 23 77288 3644 79663433
Oxygen consumption 23.41 11.01 7 77304 88 79666989
Gamma-glutamyltransferase increased 23.33 11.01 110 77201 54570 79612507
Pulmonary haemorrhage 23.31 11.01 47 77264 14670 79652407
Colitis 23.29 11.01 22 77289 73285 79593792
Multiple sclerosis relapse 23.28 11.01 8 77303 46525 79620552
Thrombocytopenia 23.25 11.01 156 77155 265103 79401974
Apnoea 23.02 11.01 41 77270 11663 79655414
Product dose omission issue 22.90 11.01 352 76959 247185 79419892
SARS-CoV-2 viraemia 22.84 11.01 6 77305 45 79667032
Psychotic disorder 22.74 11.01 6 77305 41396 79625681
Catheter site inflammation 22.64 11.01 14 77297 1127 79665950
Rhabdomyolysis 22.46 11.01 41 77270 103090 79563987
Knee arthroplasty 22.41 11.01 7 77304 43241 79623836
Infusion site erythema 22.40 11.01 36 77275 9424 79657653
Agranulocytosis 22.09 11.01 8 77303 45022 79622055
Injection site swelling 22.08 11.01 9 77302 47123 79619954
Tubulointerstitial nephritis 22.06 11.01 5 77306 38230 79628847
Bone marrow failure 22.00 11.01 11 77300 51096 79615981
White blood cell count decreased 21.81 11.01 101 77210 188187 79478890
C-reactive protein increased 21.78 11.01 59 77252 128968 79538109
Rhonchi 21.65 11.01 23 77288 4013 79663064
Rhinorrhoea 21.62 11.01 137 77174 75937 79591140
Catheter site granuloma 21.59 11.01 6 77305 57 79667020
Mediastinal effusion 21.49 11.01 6 77305 58 79667019
Secretion discharge 21.48 11.01 46 77265 14976 79652101
Neuropathy peripheral 21.40 11.01 68 77243 141237 79525840
Device leakage 21.32 11.01 38 77273 10818 79656259
Colitis ulcerative 21.17 11.01 4 77307 34738 79632339
Procedural complication 21.16 11.01 32 77279 7951 79659126
Pulmonary function test abnormal 21.15 11.01 23 77288 4121 79662956
Pulmonary trichosporonosis 21.05 11.01 6 77305 63 79667014
Cold burn 20.99 11.01 4 77307 4 79667073
Cardiac disorder 20.96 11.01 122 77189 65635 79601442
Feeling abnormal 20.79 11.01 241 77070 158958 79508119
Angioplasty 20.71 11.01 16 77295 1847 79665230
Supraventricular tachycardia 20.58 11.01 56 77255 21214 79645863
Therapy non-responder 20.21 11.01 156 77155 92149 79574928
Cytomegalovirus infection 20.21 11.01 8 77303 42636 79624441
Anaesthetic complication cardiac 20.17 11.01 6 77305 74 79667003
Right-to-left cardiac shunt 20.16 11.01 8 77303 244 79666833
Rash maculo-papular 20.06 11.01 15 77296 56063 79611014
PaO2/FiO2 ratio decreased 19.59 11.01 5 77306 33 79667044
Paraesthesia 19.59 11.01 96 77215 176227 79490850
Platelet transfusion 19.50 11.01 17 77294 2325 79664752
Uterine hypotonus 19.47 11.01 6 77305 84 79666993
Respiratory acidosis 19.22 11.01 37 77274 11163 79655914
Decreased activity 19.12 11.01 32 77279 8662 79658415
Pancreatitis 19.08 11.01 23 77288 68552 79598525
Mechanical ventilation 18.97 11.01 18 77293 2746 79664331
Myocardial infarction 18.91 11.01 103 77208 184026 79483051
Exposure during pregnancy 18.81 11.01 44 77267 101088 79565989
Pulmonary artery banding 18.76 11.01 4 77307 10 79667067
Pancreatitis haemorrhagic 18.57 11.01 11 77300 819 79666258
Abdominal cavity drainage 18.57 11.01 11 77300 819 79666258
Mouth ulceration 18.53 11.01 7 77304 38387 79628690
Pulmonary artery dilatation 18.32 11.01 9 77302 460 79666617
Blood alkaline phosphatase increased 18.31 11.01 115 77196 63549 79603528
Emergency care 18.28 11.01 12 77299 1072 79666005
Upper respiratory tract inflammation 18.20 11.01 21 77290 4014 79663063
Aspartate aminotransferase increased 18.15 11.01 210 77101 138431 79528646
Seizure 18.11 11.01 108 77203 188726 79478351
Product use issue 18.08 11.01 124 77187 209698 79457379
Bronchospasm 17.93 11.01 59 77252 24800 79642277
Hallucination 17.87 11.01 35 77276 85710 79581367
Right ventricular enlargement 17.81 11.01 10 77301 673 79666404
Delayed recovery from anaesthesia 17.80 11.01 14 77297 1659 79665418
Eosinophilia 17.73 11.01 11 77300 45334 79621743
Alkalosis hypochloraemic 17.71 11.01 9 77302 495 79666582
Angioedema 17.67 11.01 29 77282 76006 79591071
Acute postoperative sialadenitis 17.58 11.01 5 77306 52 79667025
Areflexia 17.32 11.01 24 77287 5510 79661567
Glossoptosis 17.32 11.01 7 77304 224 79666853
Jugular vein distension 17.17 11.01 13 77298 1457 79665620
Right ventricular systolic pressure increased 17.08 11.01 11 77300 951 79666126
Choking sensation 17.07 11.01 20 77291 3886 79663191
Brain hypoxia 17.07 11.01 11 77300 952 79666125
Rotavirus infection 17.04 11.01 10 77301 732 79666345
Osteoarthritis 17.04 11.01 37 77274 87272 79579805
Lower respiratory tract infection 17.00 11.01 66 77245 129154 79537923
Urine output decreased 16.99 11.01 47 77264 17975 79649102
Iron deficiency anaemia 16.82 11.01 59 77252 25613 79641464
Pulmonary capillary haemangiomatosis 16.78 11.01 5 77306 62 79667015
Ascites 16.71 11.01 128 77183 75434 79591643
Lung assist device therapy 16.62 11.01 6 77305 140 79666937
Bursitis 16.54 11.01 7 77304 35837 79631240
Myotonic dystrophy 16.43 11.01 6 77305 145 79666932
Cerebral haemorrhage 16.41 11.01 19 77292 57654 79609423
Catheter site irritation 16.33 11.01 9 77302 584 79666493
Ventricular tachycardia 16.20 11.01 82 77229 41853 79625224
Joint range of motion decreased 16.18 11.01 6 77305 33276 79633801
Exercise test abnormal 16.16 11.01 5 77306 71 79667006
Argon plasma coagulation 16.14 11.01 4 77307 23 79667054
Inappropriate antidiuretic hormone secretion 16.09 11.01 3 77308 26310 79640767
Dizziness postural 16.09 11.01 35 77276 11514 79655563
Type 2 diabetes mellitus 16.06 11.01 19 77292 57103 79609974
Injection site bruising 15.96 11.01 10 77301 40992 79626085
Complication associated with device 15.87 11.01 45 77266 17451 79649626
Rales 15.82 11.01 49 77262 19952 79647125
Jaundice 15.81 11.01 17 77294 53332 79613745
Device infusion issue 15.68 11.01 15 77296 2311 79664766
Burns third degree 15.53 11.01 8 77303 453 79666624
Thyroglobulin increased 15.50 11.01 5 77306 82 79666995
Procedural hypotension 15.48 11.01 14 77297 2009 79665068
Ill-defined disorder 15.43 11.01 25 77286 65850 79601227
Maternal exposure during pregnancy 15.36 11.01 74 77237 136464 79530613
Cerebral infarction 15.36 11.01 13 77298 45663 79621414
Blood pressure increased 15.34 11.01 131 77180 211229 79455848
Disturbance in attention 15.27 11.01 16 77295 50785 79616292
Diabetic ketoacidosis 15.21 11.01 7 77304 34115 79632962
Emotional distress 15.21 11.01 10 77301 39959 79627118
Poisoning 15.20 11.01 3 77308 25269 79641808
Middle ear effusion 15.20 11.01 15 77296 2400 79664677
Oedematous pancreatitis 15.14 11.01 11 77300 1157 79665920
Head injury 15.09 11.01 74 77237 37295 79629782
Sinus congestion 15.05 11.01 48 77263 19848 79647229
Cardioversion 15.04 11.01 14 77297 2084 79664993
Sinus disorder 15.04 11.01 52 77259 22412 79644665
Oral herpes 15.04 11.01 4 77307 27450 79639627
Cholestasis 15.01 11.01 17 77294 52092 79614985
Inflammation 14.99 11.01 44 77267 93709 79573368
Pneumonia bacterial 14.96 11.01 47 77264 19284 79647793
Multiple allergies 14.92 11.01 32 77279 10428 79656649
Respiratory syncytial virus infection 14.86 11.01 30 77281 9372 79657705
Barotrauma 14.79 11.01 6 77305 194 79666883
Localised oedema 14.55 11.01 27 77284 7925 79659152
Cutaneous mucormycosis 14.48 11.01 6 77305 205 79666872
Palmar-plantar erythrodysaesthesia syndrome 14.46 11.01 7 77304 33127 79633950
Lung infiltration 14.45 11.01 52 77259 22860 79644217
Paradoxical embolism 14.39 11.01 4 77307 38 79667039
Rehabilitation therapy 14.38 11.01 13 77298 1864 79665213
Nasal operation 14.37 11.01 6 77305 209 79666868
Catheter site dermatitis 14.35 11.01 5 77306 105 79666972
Catheter site hypersensitivity 14.21 11.01 5 77306 108 79666969
Cardiorenal syndrome 14.18 11.01 12 77299 1577 79665500
Right ventricular dilatation 14.09 11.01 13 77298 1913 79665164
Blood creatine phosphokinase increased 13.75 11.01 27 77284 66063 79601014
Seasonal allergy 13.73 11.01 41 77270 16365 79650712
Weight increased 13.69 11.01 359 76952 277027 79390050
Airway burns 13.67 11.01 3 77308 9 79667068
Terminal state 13.54 11.01 20 77291 4869 79662208
Pulmonary pain 13.41 11.01 19 77292 4454 79662623
Injury 13.41 11.01 35 77276 77461 79589616
Bradycardia 13.39 11.01 195 77116 135362 79531715
Basal cell carcinoma 13.37 11.01 10 77301 37365 79629712
Hepatocellular injury 13.20 11.01 16 77295 47577 79619500
Therapy interrupted 13.11 11.01 7 77304 31334 79635743
Incorrect dose administered 12.96 11.01 35 77276 76595 79590482
Hospice care 12.94 11.01 30 77281 10294 79656783
Myelosuppression 12.91 11.01 12 77299 40284 79626793
Sedation 12.82 11.01 19 77292 51876 79615201
Blood carbon monoxide increased 12.81 11.01 3 77308 13 79667064
Vena cava filter insertion 12.80 11.01 5 77306 146 79666931
Upper respiratory tract infection 12.79 11.01 140 77171 91028 79576049
Pulmonary thrombosis 12.74 11.01 33 77278 12138 79654939
Gastrointestinal disorder 12.74 11.01 68 77243 122137 79544940
Systemic scleroderma 12.70 11.01 10 77301 1187 79665890
PO2 decreased 12.67 11.01 15 77296 2948 79664129
Rash pruritic 12.66 11.01 32 77279 71597 79595480
Medication error 12.66 11.01 30 77281 68612 79598465
Herpes zoster 12.59 11.01 47 77264 93036 79574041
Thoracic cavity drainage 12.59 11.01 6 77305 287 79666790
Proteinuria 12.55 11.01 8 77303 32494 79634583
Inappropriate schedule of product administration 12.51 11.01 77 77234 133551 79533526
Mastitis bacterial 12.49 11.01 4 77307 64 79667013
Drug level increased 12.48 11.01 12 77299 39639 79627438
Menstrual discomfort 12.46 11.01 3 77308 15 79667062
Pulmonary vein stenosis 12.37 11.01 5 77306 160 79666917
Catheter site erosion 12.32 11.01 4 77307 67 79667010
Gastrointestinal arteriovenous malformation 12.29 11.01 9 77302 959 79666118
Adverse drug reaction 12.25 11.01 29 77282 66363 79600714
Retching 12.19 11.01 41 77270 17426 79649651
Swollen tongue 12.14 11.01 14 77297 42556 79624521
Superinfection fungal 12.10 11.01 4 77307 71 79667006
Frostbite 12.06 11.01 5 77306 171 79666906
Nightmare 12.01 11.01 5 77306 25856 79641221
Haematoma evacuation 12.01 11.01 6 77305 318 79666759
Loss of consciousness 11.96 11.01 229 77082 167714 79499363
Gastrointestinal tube insertion 11.92 11.01 11 77300 1619 79665458
Right ventricular hypertrophy 11.88 11.01 11 77300 1626 79665451
Chronic left ventricular failure 11.82 11.01 9 77302 1017 79666060
Tricuspid valve incompetence 11.81 11.01 44 77267 19668 79647409
Catheter site vesicles 11.76 11.01 6 77305 333 79666744
Oesophageal dilation procedure 11.75 11.01 4 77307 78 79666999
Puncture site infection 11.75 11.01 4 77307 78 79666999
Large intestinal polypectomy 11.74 11.01 6 77305 334 79666743
Right ventricular systolic pressure 11.73 11.01 3 77308 20 79667057
Blood triglycerides increased 11.65 11.01 3 77308 21037 79646040
Intentional product misuse 11.64 11.01 50 77261 95115 79571962
Cardiac septal defect repair 11.60 11.01 3 77308 21 79667056
Lung squamous cell carcinoma stage I 11.60 11.01 3 77308 21 79667056
Sopor 11.59 11.01 9 77302 33001 79634076
Breath sounds abnormal 11.59 11.01 38 77273 15946 79651131
Hypercholesterolaemia 11.50 11.01 4 77307 23091 79643986
Haematocrit decreased 11.47 11.01 100 77211 61212 79605865
Hepatic cytolysis 11.45 11.01 6 77305 27145 79639932
Accident 11.45 11.01 26 77285 8805 79658272
Agonal respiration 11.43 11.01 4 77307 85 79666992
Haemodynamic instability 11.43 11.01 40 77271 17342 79649735
Stress cardiomyopathy 11.41 11.01 30 77281 11136 79655941
Decreased appetite 11.29 11.01 422 76889 341996 79325081
Progressive multifocal leukoencephalopathy 11.29 11.01 3 77308 20597 79646480
Dizziness exertional 11.28 11.01 7 77304 567 79666510
PO2 abnormal 11.25 11.01 3 77308 24 79667053
Withdrawal syndrome 11.23 11.01 6 77305 26848 79640229
Cardiomyopathy 11.22 11.01 7 77304 28767 79638310
Extrapyramidal disorder 11.17 11.01 4 77307 22675 79644402
Diverticulitis 11.17 11.01 17 77294 45919 79621158
Bronchopulmonary aspergillosis 11.13 11.01 47 77264 22247 79644830
Mineral supplementation 11.09 11.01 8 77303 832 79666245
Respiratory disorder 11.07 11.01 78 77233 44778 79622299
Hip arthroplasty 11.04 11.01 11 77300 35745 79631332
Paranasal sinus hypersecretion 11.03 11.01 16 77295 3830 79663247

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AN04 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Medical gases
CHEBI has role CHEBI:77974 food packaging gases
CHEBI has role CHEBI:78017 food propellants
CHEBI has role CHEBI:33937 macronutrients

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Persistent pulmonary hypertension of the newborn indication 233815004 DOID:13042
Methemoglobinemia contraindication 38959009 DOID:10783
Left heart failure contraindication 85232009
Congenital Heart Defect Requiring Open Patent Ductus Arteriosus contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
None (Med Gas) Air Liquide Industrial U.S. L.P. 2
None (Med Gas) Air Liquide Large Industries U.S. L.P. 2
None (Med Gas) Messer LLC 2
None (Med Gas) Norco Inc. 2
None (Med Gas) Messer Gas Puerto Rico Inc. 2
None (Med Gas) Air Liquide America L.P. 2
None (Med Gas) Airgas Merchant Gases LLC 2
None (Med Gas) Praxair Inc. 2
None (Med Gas) Aspen Air, US Corp 2
None (Med Gas) Air Products and Chemicals Inc. 2
None (Med Gas) Matheson Tri-Gas Inc. 2
None (Med Gas) Praxair Canada Inc. 2
None (Med Gas) Airgas USA LLC 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019163 VUID
N0000147408 NUI
D00083 KEGG_DRUG
4019163 VANDF
C0028158 UMLSCUI
CHEBI:25555 CHEBI
NGN PDB_CHEM_ID
CHEMBL142438 ChEMBL_ID
D009584 MESH_DESCRIPTOR_UI
DB09152 DRUGBANK_ID
N762921K75 UNII
947 PUBCHEM_CID
7456 RXNORM
002515 NDDF
36012007 SNOMEDCT_US
767123001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10006-005 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10014-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10014-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10018-9502 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10167-400 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10167-400 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10218-102 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10218-102 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10221-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10221-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10221-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10252-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10252-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-002 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-200 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10297-200 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10304-601 GAS 999 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10304-601 GAS 999 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10412-0095 GAS 99.50 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10412-0095 GAS 99.50 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10451-003 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10451-003 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-003 LIQUID 990 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-006 LIQUID 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-006 LIQUID 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrogen HUMAN PRESCRIPTION DRUG LABEL 1 10526-006 LIQUID 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-020 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-021 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-022 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROGEN HUMAN PRESCRIPTION DRUG LABEL 1 10671-023 LIQUID 99 L RESPIRATORY (INHALATION) NDA 1 sections