zinc oxide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4240 1314-13-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zinc oxide
A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
  • Molecular weight: 81.38
  • Formula: OZn
  • CLOGP:
  • LIPINSKI: None
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 16, 2006 FDA DELCOR ASSET

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 58.61 43.32 16 48 46627 2311394

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Proctitis indication 3951002 DOID:3127
Tinea pedis indication 6020002 DOID:12403
Wound indication 13924000
Burn injury indication 48333001
Candidiasis of skin indication 49883006
Pityriasis versicolor indication 56454009 DOID:9060
Hemorrhoids indication 70153002 DOID:9746
Rectal pain indication 77880009
Tinea corporis indication 84849002
Pruritus ani indication 90446007
Diaper rash indication 91487003
Eruption of skin indication 271807003 DOID:0050486
Skin irritation indication 367466007
Tinea cruris indication 399029005
Arthropod bite wound indication 409985002
Itching of skin indication 418363000
Minor Bacterial Skin Infections indication
Paronychia off-label use 71906005 DOID:13117
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Anxiety contraindication 48694002
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Open wound contraindication 125643001
Hb SS disease contraindication 127040003 DOID:10923
Benign prostatic hyperplasia contraindication 266569009
Hemochromatosis contraindication 399187006 DOID:2352
Disorder of coronary artery contraindication 414024009
Denuded skin contraindication 418242004
Nervousness contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
15% VUSION MYLAN N021026 Feb. 16, 2006 RX OINTMENT TOPICAL 8147852 March 30, 2028 USE FOR TREATMENT OF DIAPER DERMATITIS COMPLICATED BY CANDIDIASIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019034 VUID
N0000147305 NUI
C0043491 UMLSCUI
D01170 KEGG_DRUG
398971002 SNOMEDCT_US
4019036 VANDF
4019034 VANDF
4017643 VANDF
5049 MMSL
11423 RXNORM
42841002 SNOMEDCT_US
5709 MMSL
001922 NDDF
14806 PUBCHEM_CID
SOI2LOH54Z UNII
DB09321 DRUGBANK_ID
D015034 MESH_DESCRIPTOR_UI
CHEMBL3988900 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
SkinMedica TNS Ultimate Daily Moisturizer Sunscreen SPF 20 HUMAN OTC DRUG LABEL 2 0023-4953 CREAM 53 mg TOPICAL OTC MONOGRAPH NOT FINAL 8 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 80 mg TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 80 mg TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 10 mg TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 60 mg TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5703 LOTION 60 mg TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5738 LOTION 120 mg TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 1 TOPICAL OTC monograph final 8 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0194 PASTE 40 g TOPICAL OTC monograph final 10 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0323 CREAM 40 g TOPICAL OTC monograph final 9 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0324 OINTMENT 16 g TOPICAL OTC MONOGRAPH FINAL 8 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0333 CREAM 16 g TOPICAL OTC monograph final 7 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0334 CREAM 16 g TOPICAL OTC monograph final 9 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0557 CREAM 16 g TOPICAL export only 10 sections
Selan Plus Zinc Oxide HUMAN OTC DRUG LABEL 2 0159-2200 CREAM 2 g TOPICAL OTC monograph final 11 sections
CALENDULA DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2189 CREAM 12 g TOPICAL OTC monograph final 8 sections
WHITE MALLOW DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2207 CREAM 14 g TOPICAL OTC monograph final 8 sections
ZINC OXIDE HUMAN OTC DRUG LABEL 1 0168-0062 OINTMENT 200 mg TOPICAL OTC monograph final 9 sections
DR SMITHS DIAPER HUMAN OTC DRUG LABEL 1 0178-0330 OINTMENT 100 mg TOPICAL OTC monograph final 11 sections
Dr Smiths Diaper Rash HUMAN OTC DRUG LABEL 1 0178-0340 SPRAY 10 g TOPICAL OTC monograph final 7 sections
Dr Smiths Diaper Rash HUMAN OTC DRUG LABEL 1 0178-0345 SPRAY 10 g TOPICAL OTC monograph final 8 sections
Dr Smiths Diaper Rash HUMAN OTC DRUG LABEL 1 0178-0348 SPRAY 10 g TOPICAL OTC monograph final 8 sections
Dr. Smiths Rash and Skin HUMAN OTC DRUG LABEL 1 0178-0370 OINTMENT 10 g TOPICAL OTC monograph not final 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 13 0178-0821 TABLET 25 mg ORAL unapproved drug other 10 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 10 0178-0829 TABLET 25 mg ORAL Unapproved drug other 10 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 11 0178-0858 TABLET 25 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 12 0178-0859 TABLET 25 mg ORAL Unapproved drug other 8 sections
CitraNatal DHA HUMAN PRESCRIPTION DRUG LABEL 14 0178-0894 KIT 25 mg None unapproved drug other 11 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 12 0178-0898 TABLET 25 mg ORAL Unapproved drug other 10 sections