zinc oxide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4240 | 1314-13-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 16, 2006 | FDA | DELCOR ASSET |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 58.61 | 43.32 | 16 | 48 | 46627 | 2311394 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003358 | Cosmetics |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D011837 | Radiation-Protective Agents |
| MeSH PA | D013473 | Sunscreening Agents |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Proctitis | indication | 3951002 | DOID:3127 |
| Tinea pedis | indication | 6020002 | DOID:12403 |
| Wound | indication | 13924000 | |
| Burn injury | indication | 48333001 | |
| Candidiasis of skin | indication | 49883006 | |
| Pityriasis versicolor | indication | 56454009 | DOID:9060 |
| Hemorrhoids | indication | 70153002 | DOID:9746 |
| Rectal pain | indication | 77880009 | |
| Tinea corporis | indication | 84849002 | |
| Pruritus ani | indication | 90446007 | |
| Diaper rash | indication | 91487003 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Skin irritation | indication | 367466007 | |
| Tinea cruris | indication | 399029005 | |
| Arthropod bite wound | indication | 409985002 | |
| Itching of skin | indication | 418363000 | |
| Minor Bacterial Skin Infections | indication | ||
| Paronychia | off-label use | 71906005 | DOID:13117 |
| Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Anxiety | contraindication | 48694002 | |
| Wilson's disease | contraindication | 88518009 | |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Open wound | contraindication | 125643001 | |
| Hb SS disease | contraindication | 127040003 | DOID:10923 |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Hemochromatosis | contraindication | 399187006 | DOID:2352 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Denuded skin | contraindication | 418242004 | |
| Nervousness | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 15% | VUSION | MYLAN | N021026 | Feb. 16, 2006 | RX | OINTMENT | TOPICAL | 8147852 | March 30, 2028 | USE FOR TREATMENT OF DIAPER DERMATITIS COMPLICATED BY CANDIDIASIS |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019034 | VUID |
| N0000147305 | NUI |
| C0043491 | UMLSCUI |
| D01170 | KEGG_DRUG |
| 398971002 | SNOMEDCT_US |
| 4019036 | VANDF |
| 4019034 | VANDF |
| 4017643 | VANDF |
| 5049 | MMSL |
| 11423 | RXNORM |
| 42841002 | SNOMEDCT_US |
| 5709 | MMSL |
| 001922 | NDDF |
| 14806 | PUBCHEM_CID |
| SOI2LOH54Z | UNII |
| DB09321 | DRUGBANK_ID |
| D015034 | MESH_DESCRIPTOR_UI |
| CHEMBL3988900 | ChEMBL_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| SkinMedica TNS Ultimate Daily Moisturizer Sunscreen SPF 20 | HUMAN OTC DRUG LABEL | 2 | 0023-4953 | CREAM | 53 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 8 sections |
| TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen | HUMAN OTC DRUG LABEL | 3 | 0023-5494 | LOTION | 80 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 10 sections |
| TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) | HUMAN OTC DRUG LABEL | 4 | 0023-5497 | LOTION | 80 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 10 sections |
| TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen | HUMAN OTC DRUG LABEL | 4 | 0023-5501 | LOTION | 10 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 10 sections |
| Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0023-5675 | LOTION | 60 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 10 sections |
| Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0023-5703 | LOTION | 60 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 10 sections |
| Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0023-5738 | LOTION | 120 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 10 sections |
| Solbar Shield SPF40 | HUMAN OTC DRUG LABEL | 2 | 0096-0682 | CREAM | 0.08 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Zinc SPF38 | HUMAN OTC DRUG LABEL | 3 | 0096-0688 | CREAM | 0.08 1 | TOPICAL | OTC monograph final | 8 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0194 | PASTE | 40 g | TOPICAL | OTC monograph final | 10 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0323 | CREAM | 40 g | TOPICAL | OTC monograph final | 9 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0324 | OINTMENT | 16 g | TOPICAL | OTC MONOGRAPH FINAL | 8 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0333 | CREAM | 16 g | TOPICAL | OTC monograph final | 7 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0334 | CREAM | 16 g | TOPICAL | OTC monograph final | 9 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0557 | CREAM | 16 g | TOPICAL | export only | 10 sections |
| Selan Plus Zinc Oxide | HUMAN OTC DRUG LABEL | 2 | 0159-2200 | CREAM | 2 g | TOPICAL | OTC monograph final | 11 sections |
| CALENDULA DIAPER RASH CREAM | HUMAN OTC DRUG LABEL | 1 | 0164-2189 | CREAM | 12 g | TOPICAL | OTC monograph final | 8 sections |
| WHITE MALLOW DIAPER RASH CREAM | HUMAN OTC DRUG LABEL | 1 | 0164-2207 | CREAM | 14 g | TOPICAL | OTC monograph final | 8 sections |
| ZINC OXIDE | HUMAN OTC DRUG LABEL | 1 | 0168-0062 | OINTMENT | 200 mg | TOPICAL | OTC monograph final | 9 sections |
| DR SMITHS DIAPER | HUMAN OTC DRUG LABEL | 1 | 0178-0330 | OINTMENT | 100 mg | TOPICAL | OTC monograph final | 11 sections |
| Dr Smiths Diaper Rash | HUMAN OTC DRUG LABEL | 1 | 0178-0340 | SPRAY | 10 g | TOPICAL | OTC monograph final | 7 sections |
| Dr Smiths Diaper Rash | HUMAN OTC DRUG LABEL | 1 | 0178-0345 | SPRAY | 10 g | TOPICAL | OTC monograph final | 8 sections |
| Dr Smiths Diaper Rash | HUMAN OTC DRUG LABEL | 1 | 0178-0348 | SPRAY | 10 g | TOPICAL | OTC monograph final | 8 sections |
| Dr. Smiths Rash and Skin | HUMAN OTC DRUG LABEL | 1 | 0178-0370 | OINTMENT | 10 g | TOPICAL | OTC monograph not final | 12 sections |
| CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0178-0821 | TABLET | 25 mg | ORAL | unapproved drug other | 10 sections |
| CitraNatal 90 DHA | HUMAN OTC DRUG LABEL | 10 | 0178-0829 | TABLET | 25 mg | ORAL | Unapproved drug other | 10 sections |
| CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 11 | 0178-0858 | TABLET | 25 mg | ORAL | Unapproved drug other | 11 sections |
| CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 12 | 0178-0859 | TABLET | 25 mg | ORAL | Unapproved drug other | 8 sections |
| CitraNatal DHA | HUMAN PRESCRIPTION DRUG LABEL | 14 | 0178-0894 | KIT | 25 mg | None | unapproved drug other | 11 sections |
| CitraNatal DHA | HUMAN OTC DRUG LABEL | 12 | 0178-0898 | TABLET | 25 mg | ORAL | Unapproved drug other | 10 sections |