zinc oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4240 | 1314-13-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 16, 2006 | FDA | DELCOR ASSET |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pemphigus | 1796.88 | 9.99 | 3873 | 438288 | 153339 | 55696567 |
| Rheumatoid arthritis | 1729.95 | 9.99 | 6746 | 435415 | 375858 | 55474048 |
| Systemic lupus erythematosus | 1674.26 | 9.99 | 4089 | 438072 | 175989 | 55673917 |
| Glossodynia | 1494.13 | 9.99 | 3534 | 438627 | 148924 | 55700982 |
| Hand deformity | 1211.89 | 9.99 | 3019 | 439142 | 131473 | 55718433 |
| Arthropathy | 1169.42 | 9.99 | 3844 | 438317 | 196431 | 55653475 |
| Alopecia | 1041.16 | 9.99 | 4811 | 437350 | 288647 | 55561259 |
| Abdominal discomfort | 1032.25 | 9.99 | 4611 | 437550 | 272663 | 55577243 |
| Wound | 1006.56 | 9.99 | 2875 | 439286 | 135929 | 55713977 |
| Maternal exposure during pregnancy | 967.06 | 9.99 | 3479 | 438682 | 186074 | 55663832 |
| Synovitis | 817.65 | 9.99 | 2955 | 439206 | 158350 | 55691556 |
| Completed suicide | 809.21 | 9.99 | 64 | 442097 | 133769 | 55716137 |
| Pericarditis | 788.21 | 9.99 | 2255 | 439906 | 106668 | 55743238 |
| Infusion related reaction | 783.00 | 9.99 | 3483 | 438678 | 205448 | 55644458 |
| Anti-cyclic citrullinated peptide antibody positive | 770.22 | 9.99 | 2099 | 440062 | 96501 | 55753405 |
| Discomfort | 753.45 | 9.99 | 2638 | 439523 | 139123 | 55710783 |
| Contraindicated product administered | 751.88 | 9.99 | 3176 | 438985 | 183110 | 55666796 |
| Joint swelling | 726.95 | 9.99 | 4317 | 437844 | 285483 | 55564423 |
| Swelling | 717.88 | 9.99 | 3747 | 438414 | 236024 | 55613882 |
| Toxicity to various agents | 637.90 | 9.99 | 498 | 441663 | 224066 | 55625840 |
| Pain | 605.26 | 9.99 | 7895 | 434266 | 655289 | 55194617 |
| Death | 543.91 | 9.99 | 1170 | 440991 | 340256 | 55509650 |
| Product use issue | 482.19 | 9.99 | 2797 | 439364 | 183244 | 55666662 |
| Duodenal ulcer perforation | 476.79 | 9.99 | 1397 | 440764 | 66945 | 55782961 |
| Helicobacter infection | 463.50 | 9.99 | 1447 | 440714 | 71821 | 55778085 |
| Rheumatoid factor positive | 463.09 | 9.99 | 1392 | 440769 | 67668 | 55782238 |
| Hepatic enzyme increased | 435.20 | 9.99 | 2563 | 439598 | 168821 | 55681085 |
| Arthralgia | 422.73 | 9.99 | 5891 | 436270 | 495778 | 55354128 |
| Drug abuse | 365.55 | 9.99 | 49 | 442112 | 67561 | 55782345 |
| Drug interaction | 365.09 | 9.99 | 682 | 441479 | 209073 | 55640833 |
| Intentional overdose | 362.09 | 9.99 | 52 | 442109 | 68065 | 55781841 |
| Drug intolerance | 357.18 | 9.99 | 3409 | 438752 | 261409 | 55588497 |
| Musculoskeletal stiffness | 345.06 | 9.99 | 2252 | 439909 | 153755 | 55696151 |
| Therapeutic product effect decreased | 342.46 | 9.99 | 2392 | 439769 | 167060 | 55682846 |
| Treatment failure | 335.43 | 9.99 | 2390 | 439771 | 168002 | 55681904 |
| Exposure during pregnancy | 293.46 | 9.99 | 1955 | 440206 | 134387 | 55715519 |
| Febrile neutropenia | 255.37 | 9.99 | 271 | 441890 | 105274 | 55744632 |
| Hip arthroplasty | 253.62 | 9.99 | 773 | 441388 | 37850 | 55812056 |
| Suicide attempt | 242.56 | 9.99 | 76 | 442085 | 57760 | 55792146 |
| Acute kidney injury | 241.66 | 9.99 | 1021 | 441140 | 239742 | 55610164 |
| Knee arthroplasty | 241.08 | 9.99 | 831 | 441330 | 43428 | 55806478 |
| Psoriatic arthropathy | 238.55 | 9.99 | 1182 | 440979 | 72826 | 55777080 |
| Hypersensitivity | 234.36 | 9.99 | 3058 | 439103 | 253350 | 55596556 |
| Overdose | 218.78 | 9.99 | 307 | 441854 | 105523 | 55744383 |
| Cardiac arrest | 216.30 | 9.99 | 215 | 441946 | 86099 | 55763807 |
| Depressed level of consciousness | 213.13 | 9.99 | 88 | 442073 | 56345 | 55793561 |
| Nasopharyngitis | 209.76 | 9.99 | 2654 | 439507 | 218305 | 55631601 |
| C-reactive protein abnormal | 209.16 | 9.99 | 701 | 441460 | 36108 | 55813798 |
| Impaired healing | 201.28 | 9.99 | 1269 | 440892 | 85572 | 55764334 |
| Diarrhoea | 199.03 | 9.99 | 3677 | 438484 | 634830 | 55215076 |
| Disease progression | 197.27 | 9.99 | 326 | 441835 | 104847 | 55745059 |
| Constipation | 196.68 | 9.99 | 866 | 441295 | 201077 | 55648829 |
| Rheumatic fever | 195.90 | 9.99 | 584 | 441577 | 28243 | 55821663 |
| Malignant neoplasm progression | 189.37 | 9.99 | 179 | 441982 | 73408 | 55776498 |
| Nausea | 185.20 | 9.99 | 4583 | 437578 | 759595 | 55090311 |
| Red blood cell sedimentation rate abnormal | 176.05 | 9.99 | 427 | 441734 | 18246 | 55831660 |
| Swollen joint count increased | 174.94 | 9.99 | 501 | 441660 | 23683 | 55826223 |
| Drug ineffective | 174.53 | 9.99 | 8848 | 433313 | 910141 | 54939765 |
| Neutropenia | 169.75 | 9.99 | 653 | 441508 | 157514 | 55692392 |
| Device expulsion | 167.14 | 9.99 | 21 | 442140 | 30428 | 55819478 |
| Folliculitis | 163.10 | 9.99 | 858 | 441303 | 54121 | 55795785 |
| Muscle injury | 162.45 | 9.99 | 829 | 441332 | 51671 | 55798235 |
| Blister | 159.13 | 9.99 | 1427 | 440734 | 107460 | 55742446 |
| Anxiety | 158.38 | 9.99 | 880 | 441281 | 192292 | 55657614 |
| Bradycardia | 154.83 | 9.99 | 181 | 441980 | 67323 | 55782583 |
| Asthenia | 152.92 | 9.99 | 1841 | 440320 | 341132 | 55508774 |
| Sleep disorder due to general medical condition, insomnia type | 151.76 | 9.99 | 709 | 441452 | 42629 | 55807277 |
| Sedation | 151.23 | 9.99 | 43 | 442118 | 34811 | 55815095 |
| Hypotension | 151.13 | 9.99 | 1250 | 440911 | 249258 | 55600648 |
| Cardiac failure | 148.83 | 9.99 | 260 | 441901 | 81833 | 55768073 |
| Lactic acidosis | 147.22 | 9.99 | 47 | 442114 | 35299 | 55814607 |
| Tremor | 145.19 | 9.99 | 477 | 441684 | 120612 | 55729294 |
| Somnolence | 144.78 | 9.99 | 725 | 441436 | 162688 | 55687218 |
| Hyponatraemia | 141.53 | 9.99 | 376 | 441785 | 101763 | 55748143 |
| Electrocardiogram QT prolonged | 141.36 | 9.99 | 132 | 442029 | 54456 | 55795450 |
| Lower respiratory tract infection | 134.26 | 9.99 | 1436 | 440725 | 113358 | 55736548 |
| Sickle cell anaemia with crisis | 132.54 | 9.99 | 180 | 441981 | 4848 | 55845058 |
| Rash | 132.05 | 9.99 | 4922 | 437239 | 488125 | 55361781 |
| Irritable bowel syndrome | 132.02 | 9.99 | 956 | 441205 | 67502 | 55782404 |
| Vomiting | 129.10 | 9.99 | 2956 | 439205 | 495272 | 55354634 |
| Dyspnoea | 126.57 | 9.99 | 3617 | 438544 | 588960 | 55260946 |
| Agitation | 125.57 | 9.99 | 153 | 442008 | 55883 | 55794023 |
| Renal failure | 123.87 | 9.99 | 448 | 441713 | 110052 | 55739854 |
| Pregnancy | 122.02 | 9.99 | 549 | 441612 | 32484 | 55817422 |
| Condition aggravated | 120.13 | 9.99 | 3552 | 438609 | 341346 | 55508560 |
| Dizziness | 116.78 | 9.99 | 2166 | 439995 | 373974 | 55475932 |
| Respiratory arrest | 115.23 | 9.99 | 48 | 442113 | 30577 | 55819329 |
| Fatigue | 113.78 | 9.99 | 7409 | 434752 | 781143 | 55068763 |
| Hyperhidrosis | 113.21 | 9.99 | 370 | 441791 | 93718 | 55756188 |
| Multiple sclerosis relapse | 112.29 | 9.99 | 112 | 442049 | 44791 | 55805115 |
| Neuropathy peripheral | 110.86 | 9.99 | 424 | 441737 | 102469 | 55747437 |
| Asthma | 110.05 | 9.99 | 483 | 441678 | 112287 | 55737619 |
| Intentional self-injury | 109.98 | 9.99 | 30 | 442131 | 24962 | 55824944 |
| Rhabdomyolysis | 109.23 | 9.99 | 95 | 442066 | 40563 | 55809343 |
| Neoplasm progression | 106.98 | 9.99 | 59 | 442102 | 31957 | 55817949 |
| Drug reaction with eosinophilia and systemic symptoms | 106.97 | 9.99 | 52 | 442109 | 30252 | 55819654 |
| Osteoarthritis | 103.63 | 9.99 | 1025 | 441136 | 79271 | 55770635 |
| Arthritis | 103.52 | 9.99 | 1220 | 440941 | 98632 | 55751274 |
| Sopor | 102.24 | 9.99 | 20 | 442141 | 20902 | 55829004 |
| Syncope | 99.86 | 9.99 | 473 | 441688 | 107726 | 55742180 |
| Myalgia | 95.24 | 9.99 | 626 | 441535 | 131399 | 55718507 |
| Cognitive disorder | 94.24 | 9.99 | 150 | 442011 | 48983 | 55800923 |
| Renal impairment | 93.27 | 9.99 | 323 | 441838 | 80390 | 55769516 |
| Live birth | 93.05 | 9.99 | 352 | 441809 | 19253 | 55830653 |
| Tachycardia | 93 | 9.99 | 471 | 441690 | 105405 | 55744501 |
| Drug hypersensitivity | 92.56 | 9.99 | 1562 | 440599 | 273643 | 55576263 |
| Cardio-respiratory arrest | 92.49 | 9.99 | 184 | 441977 | 55137 | 55794769 |
| Drug withdrawal syndrome | 91.83 | 9.99 | 44 | 442117 | 25813 | 55824093 |
| Serotonin syndrome | 91.18 | 9.99 | 47 | 442114 | 26443 | 55823463 |
| Blood cholesterol increased | 90.52 | 9.99 | 920 | 441241 | 71659 | 55778247 |
| Drug dependence | 90.28 | 9.99 | 32 | 442129 | 22501 | 55827405 |
| Type 2 diabetes mellitus | 88.37 | 9.99 | 651 | 441510 | 46211 | 55803695 |
| Hypoglycaemia | 87.95 | 9.99 | 192 | 441969 | 55623 | 55794283 |
| Plasma cell myeloma | 86.11 | 9.99 | 146 | 442015 | 46500 | 55803406 |
| Product quality issue | 85.44 | 9.99 | 74 | 442087 | 31662 | 55818244 |
| Anaemia | 84.93 | 9.99 | 1534 | 440627 | 265977 | 55583929 |
| Coma | 83.83 | 9.99 | 218 | 441943 | 59437 | 55790469 |
| Abortion spontaneous | 83.76 | 9.99 | 610 | 441551 | 43143 | 55806763 |
| Hypoxia | 83.62 | 9.99 | 187 | 441974 | 53710 | 55796196 |
| Seizure | 83.45 | 9.99 | 607 | 441554 | 124512 | 55725394 |
| Ill-defined disorder | 82.23 | 9.99 | 862 | 441299 | 67681 | 55782225 |
| Pulmonary arterial hypertension | 81.33 | 9.99 | 54 | 442107 | 26449 | 55823457 |
| Infection | 80.84 | 9.99 | 2102 | 440059 | 198104 | 55651802 |
| Insomnia | 80.40 | 9.99 | 1043 | 441118 | 190817 | 55659089 |
| Peripheral swelling | 79.85 | 9.99 | 2411 | 439750 | 232315 | 55617591 |
| Hepatic failure | 79.81 | 9.99 | 87 | 442074 | 33399 | 55816507 |
| Thrombocytopenia | 79.66 | 9.99 | 685 | 441476 | 135539 | 55714367 |
| Hyperglycaemia | 79.11 | 9.99 | 111 | 442050 | 38170 | 55811736 |
| Balance disorder | 78.79 | 9.99 | 321 | 441840 | 76199 | 55773707 |
| Cardiac failure congestive | 77.16 | 9.99 | 390 | 441771 | 87330 | 55762576 |
| Metabolic acidosis | 77.12 | 9.99 | 124 | 442037 | 40330 | 55809576 |
| Blood pressure fluctuation | 76.86 | 9.99 | 562 | 441599 | 39798 | 55810108 |
| No adverse event | 76.65 | 9.99 | 104 | 442057 | 36270 | 55813636 |
| Drug resistance | 76.00 | 9.99 | 33 | 442128 | 20509 | 55829397 |
| Feeling abnormal | 75.83 | 9.99 | 677 | 441484 | 132925 | 55716981 |
| Sinusitis | 75.05 | 9.99 | 2058 | 440103 | 195523 | 55654383 |
| Palmar-plantar erythrodysaesthesia syndrome | 74.57 | 9.99 | 36 | 442125 | 21029 | 55828877 |
| Depression | 74.43 | 9.99 | 982 | 441179 | 179135 | 55670771 |
| Liver injury | 73.65 | 9.99 | 572 | 441589 | 41276 | 55808630 |
| Encephalopathy | 72.43 | 9.99 | 103 | 442058 | 35222 | 55814684 |
| Fibromyalgia | 72.17 | 9.99 | 751 | 441410 | 58852 | 55791054 |
| Sedation complication | 72.15 | 9.99 | 5 | 442156 | 11667 | 55838239 |
| Dehydration | 71.96 | 9.99 | 849 | 441312 | 157976 | 55691930 |
| Joint effusion | 71.95 | 9.99 | 269 | 441892 | 14629 | 55835277 |
| Red blood cell sedimentation rate increased | 71.48 | 9.99 | 513 | 441648 | 36110 | 55813796 |
| Respiratory failure | 71.47 | 9.99 | 445 | 441716 | 94617 | 55755289 |
| Foot deformity | 71.45 | 9.99 | 373 | 441788 | 23452 | 55826454 |
| Chest discomfort | 70.64 | 9.99 | 470 | 441691 | 98387 | 55751519 |
| Contusion | 70.09 | 9.99 | 1407 | 440754 | 127023 | 55722883 |
| Orthostatic hypotension | 68.87 | 9.99 | 96 | 442065 | 33103 | 55816803 |
| Intentional product use issue | 68.60 | 9.99 | 1133 | 441028 | 98600 | 55751306 |
| Multiple organ dysfunction syndrome | 68.07 | 9.99 | 201 | 441960 | 52569 | 55797337 |
| Joint stiffness | 67.86 | 9.99 | 494 | 441667 | 34931 | 55814975 |
| Blood glucose increased | 66.73 | 9.99 | 333 | 441828 | 74818 | 55775088 |
| Vision blurred | 66.72 | 9.99 | 380 | 441781 | 82563 | 55767343 |
| Hallucination | 66.49 | 9.99 | 183 | 441978 | 48966 | 55800940 |
| Muscle spasms | 63.90 | 9.99 | 730 | 441431 | 136641 | 55713265 |
| Pulmonary embolism | 63.82 | 9.99 | 536 | 441625 | 106588 | 55743318 |
| Fluid retention | 62.07 | 9.99 | 217 | 441944 | 53861 | 55796045 |
| Disability assessment scale score increased | 61.63 | 9.99 | 91 | 442070 | 2653 | 55847253 |
| Altered state of consciousness | 61.58 | 9.99 | 54 | 442107 | 22967 | 55826939 |
| Intentional product misuse | 60.93 | 9.99 | 204 | 441957 | 51300 | 55798606 |
| Cholestasis | 60.80 | 9.99 | 73 | 442088 | 26840 | 55823066 |
| Blood pressure diastolic abnormal | 60.73 | 9.99 | 215 | 441946 | 11383 | 55838523 |
| Injection site erythema | 59.76 | 9.99 | 897 | 441264 | 76551 | 55773355 |
| White blood cell count decreased | 59.59 | 9.99 | 667 | 441494 | 125323 | 55724583 |
| Metastases to bone | 59.52 | 9.99 | 40 | 442121 | 19468 | 55830438 |
| Muscle spasticity | 59.47 | 9.99 | 42 | 442119 | 19918 | 55829988 |
| Osteoporosis | 59.34 | 9.99 | 648 | 441513 | 51404 | 55798502 |
| Basal cell carcinoma | 59.28 | 9.99 | 370 | 441791 | 24851 | 55825055 |
| Hyperkalaemia | 59.13 | 9.99 | 203 | 441958 | 50662 | 55799244 |
| Disturbance in attention | 59.01 | 9.99 | 103 | 442058 | 32437 | 55817469 |
| Hepatic function abnormal | 58.57 | 9.99 | 114 | 442047 | 34444 | 55815462 |
| Neutrophil count decreased | 58.48 | 9.99 | 198 | 441963 | 49624 | 55800282 |
| Bone erosion | 58.42 | 9.99 | 253 | 441908 | 14721 | 55835185 |
| Cytomegalovirus infection | 58.29 | 9.99 | 40 | 442121 | 19256 | 55830650 |
| Mental status changes | 58.26 | 9.99 | 130 | 442031 | 37371 | 55812535 |
| Urticaria | 57.85 | 9.99 | 794 | 441367 | 143882 | 55706024 |
| Hepatocellular injury | 57.71 | 9.99 | 74 | 442087 | 26440 | 55823466 |
| Grip strength decreased | 57.67 | 9.99 | 267 | 441894 | 15989 | 55833917 |
| Myocardial infarction | 57.45 | 9.99 | 460 | 441701 | 92410 | 55757496 |
| Emotional distress | 56.94 | 9.99 | 91 | 442070 | 29672 | 55820234 |
| Loss of consciousness | 56.11 | 9.99 | 568 | 441593 | 108781 | 55741125 |
| Creatinine renal clearance decreased | 56.11 | 9.99 | 22 | 442139 | 14537 | 55835369 |
| Leukopenia | 55.46 | 9.99 | 328 | 441833 | 70612 | 55779294 |
| Blood pressure systolic increased | 54.97 | 9.99 | 526 | 441635 | 40310 | 55809596 |
| Joint laxity | 54.94 | 9.99 | 81 | 442080 | 2358 | 55847548 |
| Suicidal ideation | 54.69 | 9.99 | 250 | 441911 | 57492 | 55792414 |
| Product use in unapproved indication | 54.48 | 9.99 | 778 | 441383 | 140044 | 55709862 |
| Angioedema | 54.11 | 9.99 | 157 | 442004 | 41296 | 55808610 |
| Restlessness | 54.03 | 9.99 | 78 | 442083 | 26508 | 55823398 |
| Blood pressure decreased | 53.96 | 9.99 | 259 | 441902 | 58791 | 55791115 |
| Injection site pruritus | 53.95 | 9.99 | 535 | 441626 | 41396 | 55808510 |
| Ejection fraction decreased | 53.73 | 9.99 | 46 | 442115 | 19795 | 55830111 |
| Blood pressure systolic abnormal | 53.59 | 9.99 | 184 | 441977 | 9593 | 55840313 |
| Diabetic ketoacidosis | 53.28 | 9.99 | 42 | 442119 | 18829 | 55831077 |
| Caesarean section | 53.23 | 9.99 | 259 | 441902 | 15832 | 55834074 |
| Mydriasis | 53.22 | 9.99 | 11 | 442150 | 11060 | 55838846 |
| Hypokalaemia | 52.93 | 9.99 | 480 | 441681 | 93957 | 55755949 |
| Musculoskeletal pain | 52.91 | 9.99 | 914 | 441247 | 80238 | 55769668 |
| Dyspnoea exertional | 52.86 | 9.99 | 235 | 441926 | 54454 | 55795452 |
| Weight increased | 52.80 | 9.99 | 2257 | 439904 | 227446 | 55622460 |
| Platelet count decreased | 52.38 | 9.99 | 558 | 441603 | 105825 | 55744081 |
| Inflammation | 52.14 | 9.99 | 797 | 441364 | 68274 | 55781632 |
| Respiratory disorder | 50.90 | 9.99 | 120 | 442041 | 33837 | 55816069 |
| Loss of personal independence in daily activities | 50.75 | 9.99 | 910 | 441251 | 80459 | 55769447 |
| Acute hepatic failure | 50.57 | 9.99 | 34 | 442127 | 16544 | 55833362 |
| Decreased appetite | 50.20 | 9.99 | 1324 | 440837 | 217907 | 55631999 |
| Poisoning | 49.98 | 9.99 | 19 | 442142 | 12794 | 55837112 |
| Osteonecrosis of jaw | 49.91 | 9.99 | 118 | 442043 | 33240 | 55816666 |
| Deep vein thrombosis | 49.14 | 9.99 | 378 | 441783 | 76599 | 55773307 |
| Shock | 49.01 | 9.99 | 59 | 442102 | 21669 | 55828237 |
| Dysphagia | 48.81 | 9.99 | 410 | 441751 | 81537 | 55768369 |
| Memory impairment | 48.49 | 9.99 | 440 | 441721 | 86117 | 55763789 |
| Disorientation | 48.28 | 9.99 | 138 | 442023 | 36475 | 55813431 |
| Speech disorder | 48.22 | 9.99 | 143 | 442018 | 37350 | 55812556 |
| Palpitations | 48.18 | 9.99 | 525 | 441636 | 99147 | 55750759 |
| Drug level increased | 48.12 | 9.99 | 55 | 442106 | 20670 | 55829236 |
| Hospitalisation | 48.01 | 9.99 | 368 | 441793 | 74632 | 55775274 |
| Stomatitis | 48.01 | 9.99 | 1266 | 440895 | 119544 | 55730362 |
| Drug ineffective for unapproved indication | 47.80 | 9.99 | 80 | 442081 | 25613 | 55824293 |
| Unresponsive to stimuli | 47.64 | 9.99 | 112 | 442049 | 31613 | 55818293 |
| Schizophrenia | 47.34 | 9.99 | 12 | 442149 | 10487 | 55839419 |
| Flushing | 47.24 | 9.99 | 339 | 441822 | 69761 | 55780145 |
| Extrapyramidal disorder | 47.08 | 9.99 | 19 | 442142 | 12337 | 55837569 |
| Blood calcium decreased | 47.07 | 9.99 | 71 | 442090 | 23698 | 55826208 |
| Pulmonary fibrosis | 47.07 | 9.99 | 397 | 441764 | 29361 | 55820545 |
| Anaphylactic reaction | 47.06 | 9.99 | 271 | 441890 | 58724 | 55791182 |
| Multiple fractures | 46.38 | 9.99 | 145 | 442016 | 7196 | 55842710 |
| COVID-19 | 46.32 | 9.99 | 372 | 441789 | 74686 | 55775220 |
| Bone pain | 45.92 | 9.99 | 220 | 441941 | 49965 | 55799941 |
| Blood creatine phosphokinase increased | 45.83 | 9.99 | 94 | 442067 | 27858 | 55822048 |
| C-reactive protein increased | 45.60 | 9.99 | 870 | 441291 | 77814 | 55772092 |
| Blood alkaline phosphatase increased | 45.55 | 9.99 | 155 | 442006 | 38790 | 55811116 |
| Pain in jaw | 45.05 | 9.99 | 162 | 441999 | 39874 | 55810032 |
| Abnormal behaviour | 44.72 | 9.99 | 56 | 442105 | 20216 | 55829690 |
| Foetal exposure during pregnancy | 44.70 | 9.99 | 434 | 441727 | 33389 | 55816517 |
| Gamma-glutamyltransferase increased | 44.56 | 9.99 | 112 | 442049 | 30893 | 55819013 |
| Atrial fibrillation | 44.48 | 9.99 | 595 | 441566 | 108302 | 55741604 |
| Dysgeusia | 44.43 | 9.99 | 168 | 441993 | 40747 | 55809159 |
| Joint range of motion decreased | 44.24 | 9.99 | 346 | 441815 | 25019 | 55824887 |
| Ascites | 44.20 | 9.99 | 149 | 442012 | 37395 | 55812511 |
| Wrong technique in product usage process | 43.86 | 9.99 | 272 | 441889 | 57896 | 55792010 |
| Multiple sclerosis | 43.50 | 9.99 | 96 | 442065 | 27706 | 55822200 |
| Disability | 43.21 | 9.99 | 241 | 441920 | 15539 | 55834367 |
| Dysarthria | 43.20 | 9.99 | 162 | 441999 | 39388 | 55810518 |
| Product dose omission issue | 43.15 | 9.99 | 1251 | 440910 | 203502 | 55646404 |
| Hypothermia | 43.10 | 9.99 | 22 | 442139 | 12448 | 55837458 |
| Drug tolerance decreased | 43.03 | 9.99 | 214 | 441947 | 13197 | 55836709 |
| Cerebral haemorrhage | 42.95 | 9.99 | 101 | 442060 | 28505 | 55821401 |
| Product administration error | 42.93 | 9.99 | 61 | 442100 | 20868 | 55829038 |
| Premature labour | 42.77 | 9.99 | 196 | 441965 | 11686 | 55838220 |
| Injection site reaction | 42.75 | 9.99 | 621 | 441540 | 52626 | 55797280 |
| Cerebrovascular accident | 42.53 | 9.99 | 537 | 441624 | 98733 | 55751173 |
| Aspartate aminotransferase increased | 42.40 | 9.99 | 429 | 441732 | 82173 | 55767733 |
| Metastases to liver | 42.25 | 9.99 | 65 | 442096 | 21521 | 55828385 |
| Neck deformity | 42.17 | 9.99 | 65 | 442096 | 1970 | 55847936 |
| Gestational diabetes | 41.81 | 9.99 | 149 | 442012 | 7915 | 55841991 |
| Vertigo | 41.77 | 9.99 | 254 | 441907 | 54318 | 55795588 |
| Torsade de pointes | 41.45 | 9.99 | 23 | 442138 | 12417 | 55837489 |
| Blood pressure diastolic decreased | 41.44 | 9.99 | 277 | 441884 | 19046 | 55830860 |
| Respiratory depression | 41.42 | 9.99 | 23 | 442138 | 12412 | 55837494 |
| Cytokine release syndrome | 40.98 | 9.99 | 17 | 442144 | 10858 | 55839048 |
| Joint destruction | 40.79 | 9.99 | 109 | 442052 | 4946 | 55844960 |
| Pulmonary oedema | 40.75 | 9.99 | 235 | 441926 | 50908 | 55798998 |
| Rheumatoid nodule | 40.75 | 9.99 | 227 | 441934 | 14630 | 55835276 |
| Chest pain | 40.65 | 9.99 | 1157 | 441004 | 188640 | 55661266 |
| Chronic kidney disease | 40.47 | 9.99 | 181 | 441980 | 41875 | 55808031 |
| Joint injury | 40.44 | 9.99 | 342 | 441819 | 25312 | 55824594 |
| Blood bilirubin increased | 40.21 | 9.99 | 131 | 442030 | 33223 | 55816683 |
| Posterior reversible encephalopathy syndrome | 39.68 | 9.99 | 40 | 442121 | 15920 | 55833986 |
| Infective pulmonary exacerbation of cystic fibrosis | 39.43 | 9.99 | 8 | 442153 | 8149 | 55841757 |
| Haemorrhage | 38.85 | 9.99 | 271 | 441890 | 56126 | 55793780 |
| Disseminated intravascular coagulation | 38.84 | 9.99 | 50 | 442111 | 17835 | 55832071 |
| Device dislocation | 38.81 | 9.99 | 74 | 442087 | 22532 | 55827374 |
| Maternal exposure before pregnancy | 38.80 | 9.99 | 130 | 442031 | 6693 | 55843213 |
| Arrhythmia | 38.78 | 9.99 | 143 | 442018 | 34940 | 55814966 |
| Back pain | 38.70 | 9.99 | 1497 | 440664 | 235673 | 55614233 |
| Pleural effusion | 38.66 | 9.99 | 457 | 441704 | 85023 | 55764883 |
| Alanine aminotransferase increased | 38.52 | 9.99 | 511 | 441650 | 93151 | 55756755 |
| Anaphylactic shock | 38.35 | 9.99 | 70 | 442091 | 21670 | 55828236 |
| Maternal drugs affecting foetus | 38.28 | 9.99 | 107 | 442054 | 4986 | 55844920 |
| Pulmonary hypertension | 38.12 | 9.99 | 149 | 442012 | 35795 | 55814111 |
| Withdrawal syndrome | 37.68 | 9.99 | 54 | 442107 | 18408 | 55831498 |
| Psychotic disorder | 37.14 | 9.99 | 81 | 442080 | 23477 | 55826429 |
| Ventricular tachycardia | 36.96 | 9.99 | 47 | 442114 | 16854 | 55833052 |
| Akathisia | 36.93 | 9.99 | 11 | 442150 | 8641 | 55841265 |
| Injection site swelling | 36.89 | 9.99 | 513 | 441648 | 43065 | 55806841 |
| Polyarthritis | 36.80 | 9.99 | 151 | 442010 | 8577 | 55841329 |
| Delirium | 36.26 | 9.99 | 191 | 441970 | 42326 | 55807580 |
| Tuberculosis | 36.11 | 9.99 | 177 | 441984 | 10852 | 55839054 |
| Dyskinesia | 36.02 | 9.99 | 113 | 442048 | 28995 | 55820911 |
| Inappropriate antidiuretic hormone secretion | 34.74 | 9.99 | 34 | 442127 | 13722 | 55836184 |
| Blood creatinine increased | 34.64 | 9.99 | 433 | 441728 | 79758 | 55770148 |
| Acute respiratory failure | 34.48 | 9.99 | 126 | 442035 | 30868 | 55819038 |
| Neuroleptic malignant syndrome | 34.40 | 9.99 | 24 | 442137 | 11454 | 55838452 |
| Enthesopathy | 34.39 | 9.99 | 140 | 442021 | 7923 | 55841983 |
| Device difficult to use | 34.29 | 9.99 | 21 | 442140 | 10740 | 55839166 |
| Accidental overdose | 34.24 | 9.99 | 68 | 442093 | 20393 | 55829513 |
| Ventricular fibrillation | 34.03 | 9.99 | 22 | 442139 | 10930 | 55838976 |
| Sepsis | 34.00 | 9.99 | 837 | 441324 | 139003 | 55710903 |
| Gastrointestinal haemorrhage | 33.98 | 9.99 | 407 | 441754 | 75544 | 55774362 |
| Localised infection | 33.93 | 9.99 | 347 | 441814 | 27065 | 55822841 |
| Respiratory distress | 33.76 | 9.99 | 131 | 442030 | 31536 | 55818370 |
| Juvenile idiopathic arthritis | 33.66 | 9.99 | 98 | 442063 | 4675 | 55845231 |
| Nightmare | 33.57 | 9.99 | 50 | 442111 | 16776 | 55833130 |
| Melaena | 33.49 | 9.99 | 112 | 442049 | 28178 | 55821728 |
| Brain oedema | 33.29 | 9.99 | 33 | 442128 | 13238 | 55836668 |
| Polyneuropathy | 33.26 | 9.99 | 32 | 442129 | 13018 | 55836888 |
| Coagulopathy | 33.25 | 9.99 | 60 | 442101 | 18656 | 55831250 |
| Laryngitis | 33.14 | 9.99 | 205 | 441956 | 13725 | 55836181 |
| Breast cancer metastatic | 32.82 | 9.99 | 44 | 442117 | 15425 | 55834481 |
| Joint dislocation | 32.56 | 9.99 | 224 | 441937 | 15549 | 55834357 |
| Eosinophilia | 32.51 | 9.99 | 68 | 442093 | 20009 | 55829897 |
| Tenderness | 31.93 | 9.99 | 269 | 441892 | 19886 | 55830020 |
| Nodule | 31.93 | 9.99 | 253 | 441908 | 18366 | 55831540 |
| Neurotoxicity | 31.45 | 9.99 | 47 | 442114 | 15748 | 55834158 |
| Hemiparesis | 31.37 | 9.99 | 77 | 442084 | 21413 | 55828493 |
| Fall | 31.25 | 9.99 | 2401 | 439760 | 355109 | 55494797 |
| Ventricular septal defect | 31.16 | 9.99 | 87 | 442074 | 4051 | 55845855 |
| Jaundice | 31.00 | 9.99 | 110 | 442051 | 27184 | 55822722 |
| Immune reconstitution inflammatory syndrome | 30.93 | 9.99 | 4 | 442157 | 5670 | 55844236 |
| Headache | 30.90 | 9.99 | 3883 | 438278 | 555161 | 55294745 |
| Bronchospasm | 30.84 | 9.99 | 47 | 442114 | 15622 | 55834284 |
| Abdominal pain | 30.82 | 9.99 | 1690 | 440471 | 257115 | 55592791 |
| Depressed mood | 30.64 | 9.99 | 164 | 441997 | 36195 | 55813711 |
| Pre-eclampsia | 30.56 | 9.99 | 140 | 442021 | 8346 | 55841560 |
| Irritability | 30.52 | 9.99 | 124 | 442037 | 29464 | 55820442 |
| Limb deformity | 30.43 | 9.99 | 83 | 442078 | 3812 | 55846094 |
| Acute generalised exanthematous pustulosis | 30.43 | 9.99 | 20 | 442141 | 9849 | 55840057 |
| Gastrointestinal disorder | 30.43 | 9.99 | 1127 | 441034 | 111575 | 55738331 |
| Status epilepticus | 30.20 | 9.99 | 45 | 442116 | 15096 | 55834810 |
| Obstructive airways disorder | 30.17 | 9.99 | 56 | 442105 | 17226 | 55832680 |
| Pancreatitis acute | 30.06 | 9.99 | 99 | 442062 | 25025 | 55824881 |
| Disease recurrence | 29.96 | 9.99 | 92 | 442069 | 23768 | 55826138 |
| Mania | 29.65 | 9.99 | 28 | 442133 | 11492 | 55838414 |
| Crying | 29.62 | 9.99 | 79 | 442082 | 21361 | 55828545 |
| Lethargy | 29.45 | 9.99 | 260 | 441901 | 51181 | 55798725 |
| Asphyxia | 29.44 | 9.99 | 5 | 442156 | 5784 | 55844122 |
| Diabetes mellitus inadequate control | 29.42 | 9.99 | 40 | 442121 | 13940 | 55835966 |
| Injection site pain | 29.21 | 9.99 | 1161 | 441000 | 115957 | 55733949 |
| Heart rate decreased | 29.17 | 9.99 | 463 | 441698 | 39964 | 55809942 |
| Premature rupture of membranes | 29.08 | 9.99 | 93 | 442068 | 4672 | 55845234 |
| Adverse event | 28.97 | 9.99 | 603 | 441558 | 54773 | 55795133 |
| Hypomagnesaemia | 28.96 | 9.99 | 100 | 442061 | 24915 | 55824991 |
| Second primary malignancy | 28.83 | 9.99 | 11 | 442150 | 7391 | 55842515 |
| Agranulocytosis | 28.72 | 9.99 | 87 | 442074 | 22572 | 55827334 |
| Haematotoxicity | 28.66 | 9.99 | 15 | 442146 | 8368 | 55841538 |
| Parkinsonism | 28.56 | 9.99 | 20 | 442141 | 9526 | 55840380 |
| Panic attack | 28.51 | 9.99 | 75 | 442086 | 20372 | 55829534 |
| Small for dates baby | 28.36 | 9.99 | 76 | 442085 | 3454 | 55846452 |
| Psoriasis | 28.27 | 9.99 | 940 | 441221 | 91752 | 55758154 |
| Paralysis | 28.26 | 9.99 | 18 | 442143 | 9014 | 55840892 |
| Transplant rejection | 28.18 | 9.99 | 22 | 442139 | 9912 | 55839994 |
| Tenosynovitis stenosans | 28.17 | 9.99 | 63 | 442098 | 2551 | 55847355 |
| Tenosynovitis | 28.16 | 9.99 | 181 | 441980 | 12280 | 55837626 |
| Pain in extremity | 28.13 | 9.99 | 2707 | 439454 | 294724 | 55555182 |
| Fear | 28.12 | 9.99 | 46 | 442115 | 14862 | 55835044 |
| Atrioventricular block complete | 27.78 | 9.99 | 12 | 442149 | 7482 | 55842424 |
| Thrombotic microangiopathy | 27.78 | 9.99 | 20 | 442141 | 9391 | 55840515 |
| Lupus-like syndrome | 27.77 | 9.99 | 180 | 441981 | 12247 | 55837659 |
| Latent tuberculosis | 27.75 | 9.99 | 61 | 442100 | 2441 | 55847465 |
| Blood pressure diastolic increased | 27.75 | 9.99 | 137 | 442024 | 8424 | 55841482 |
| Femur fracture | 27.59 | 9.99 | 448 | 441713 | 38847 | 55811059 |
| Accidental exposure to product | 27.55 | 9.99 | 100 | 442061 | 24547 | 55825359 |
| Blood potassium decreased | 27.54 | 9.99 | 184 | 441977 | 38488 | 55811418 |
| Dry skin | 27.46 | 9.99 | 237 | 441924 | 46872 | 55803034 |
| Metastases to central nervous system | 27.32 | 9.99 | 33 | 442128 | 12103 | 55837803 |
| Unevaluable event | 27.31 | 9.99 | 241 | 441920 | 47446 | 55802460 |
| Hypervolaemia | 27.22 | 9.99 | 111 | 442050 | 26347 | 55823559 |
| Device use error | 27.12 | 9.99 | 5 | 442156 | 5451 | 55844455 |
| Stress cardiomyopathy | 26.93 | 9.99 | 16 | 442145 | 8320 | 55841586 |
| Tardive dyskinesia | 26.54 | 9.99 | 15 | 442146 | 8016 | 55841890 |
| Skin ulcer | 26.30 | 9.99 | 438 | 441723 | 38170 | 55811736 |
| Acute myeloid leukaemia | 26.22 | 9.99 | 59 | 442102 | 16913 | 55832993 |
| Aggression | 26.13 | 9.99 | 87 | 442074 | 21919 | 55827987 |
| Cytopenia | 25.95 | 9.99 | 23 | 442138 | 9732 | 55840174 |
| Complication of device insertion | 25.95 | 9.99 | 9 | 442152 | 6415 | 55843491 |
| Myoclonus | 25.89 | 9.99 | 50 | 442111 | 15153 | 55834753 |
| Cardiogenic shock | 25.84 | 9.99 | 56 | 442105 | 16269 | 55833637 |
| Dystonia | 25.68 | 9.99 | 36 | 442125 | 12385 | 55837521 |
| Ischaemic stroke | 25.66 | 9.99 | 59 | 442102 | 16783 | 55833123 |
| Injection site rash | 25.64 | 9.99 | 224 | 441937 | 16734 | 55833172 |
| Anhedonia | 25.63 | 9.99 | 24 | 442137 | 9890 | 55840016 |
| Smear cervix abnormal | 25.58 | 9.99 | 63 | 442098 | 2718 | 55847188 |
| Hyperlipidaemia | 25.57 | 9.99 | 66 | 442095 | 18043 | 55831863 |
| Abdominal distension | 25.57 | 9.99 | 442 | 441719 | 77184 | 55772722 |
| Glycosylated haemoglobin increased | 25.52 | 9.99 | 30 | 442131 | 11135 | 55838771 |
| Bradyphrenia | 25.51 | 9.99 | 10 | 442151 | 6610 | 55843296 |
| International normalised ratio increased | 25.48 | 9.99 | 222 | 441939 | 43819 | 55806087 |
| Hypomania | 25.45 | 9.99 | 4 | 442157 | 4898 | 55845008 |
| Toxic skin eruption | 25.30 | 9.99 | 33 | 442128 | 11706 | 55838200 |
| Therapy non-responder | 25.24 | 9.99 | 646 | 441515 | 60709 | 55789197 |
| Febrile bone marrow aplasia | 25.21 | 9.99 | 10 | 442151 | 6562 | 55843344 |
| Substance abuse | 25.13 | 9.99 | 3 | 442158 | 4522 | 55845384 |
| Wheelchair user | 25.00 | 9.99 | 97 | 442064 | 5369 | 55844537 |
| Graft versus host disease | 24.91 | 9.99 | 11 | 442150 | 6770 | 55843136 |
| Maternal exposure timing unspecified | 24.61 | 9.99 | 96 | 442065 | 5327 | 55844579 |
| Dysmorphism | 24.59 | 9.99 | 54 | 442107 | 2159 | 55847747 |
| Sinus tachycardia | 24.47 | 9.99 | 92 | 442069 | 22352 | 55827554 |
| Injection site bruising | 24.43 | 9.99 | 432 | 441729 | 38089 | 55811817 |
| Haemorrhage intracranial | 24.40 | 9.99 | 39 | 442122 | 12716 | 55837190 |
| Metastases to lung | 24.19 | 9.99 | 34 | 442127 | 11684 | 55838222 |
| Synovial cyst | 24.09 | 9.99 | 139 | 442022 | 9075 | 55840831 |
| Complication associated with device | 24.01 | 9.99 | 53 | 442108 | 15297 | 55834609 |
| Face oedema | 24.00 | 9.99 | 70 | 442091 | 18382 | 55831524 |
| Stevens-Johnson syndrome | 24.00 | 9.99 | 94 | 442067 | 22569 | 55827337 |
| Psychomotor hyperactivity | 23.97 | 9.99 | 25 | 442136 | 9795 | 55840111 |
| Dislocation of vertebra | 23.88 | 9.99 | 95 | 442066 | 5320 | 55844586 |
| Genital haemorrhage | 23.88 | 9.99 | 12 | 442149 | 6850 | 55843056 |
| Post transplant lymphoproliferative disorder | 23.83 | 9.99 | 4 | 442157 | 4668 | 55845238 |
| Nervousness | 23.83 | 9.99 | 132 | 442029 | 28883 | 55821023 |
| Miosis | 23.74 | 9.99 | 11 | 442150 | 6581 | 55843325 |
| Pancreatitis | 23.59 | 9.99 | 233 | 441928 | 44847 | 55805059 |
| Aphasia | 23.57 | 9.99 | 141 | 442020 | 30274 | 55819632 |
| Tachypnoea | 23.55 | 9.99 | 54 | 442107 | 15376 | 55834530 |
| Cardiac failure acute | 23.51 | 9.99 | 21 | 442140 | 8852 | 55841054 |
| Subdural haematoma | 23.34 | 9.99 | 44 | 442117 | 13455 | 55836451 |
| Proteinuria | 23.33 | 9.99 | 66 | 442095 | 17504 | 55832402 |
| Developmental hip dysplasia | 23.23 | 9.99 | 39 | 442122 | 1272 | 55848634 |
| Tumour lysis syndrome | 23.18 | 9.99 | 17 | 442144 | 7906 | 55842000 |
| Dementia | 23.12 | 9.99 | 64 | 442097 | 17094 | 55832812 |
| Urinary retention | 22.90 | 9.99 | 128 | 442033 | 27946 | 55821960 |
| Myelosuppression | 22.86 | 9.99 | 66 | 442095 | 17389 | 55832517 |
| Arthritis infective | 22.75 | 9.99 | 100 | 442061 | 5856 | 55844050 |
| Retinitis | 22.72 | 9.99 | 79 | 442082 | 4145 | 55845761 |
| Red blood cell sedimentation rate | 22.68 | 9.99 | 80 | 442081 | 4228 | 55845678 |
| Haemophagocytic lymphohistiocytosis | 22.66 | 9.99 | 25 | 442136 | 9547 | 55840359 |
| Acute graft versus host disease | 22.62 | 9.99 | 3 | 442158 | 4172 | 55845734 |
| Angina pectoris | 22.58 | 9.99 | 128 | 442033 | 27848 | 55822058 |
| Atrioventricular block | 22.56 | 9.99 | 13 | 442148 | 6874 | 55843032 |
| Muscular weakness | 22.53 | 9.99 | 636 | 441525 | 103816 | 55746090 |
| Product adhesion issue | 22.51 | 9.99 | 4 | 442157 | 4479 | 55845427 |
| Lymphocyte count decreased | 22.46 | 9.99 | 128 | 442033 | 27811 | 55822095 |
| Device related infection | 22.38 | 9.99 | 92 | 442069 | 21788 | 55828118 |
| Synovial fluid analysis | 22.35 | 9.99 | 48 | 442113 | 1890 | 55848016 |
| Muscle twitching | 22.32 | 9.99 | 60 | 442101 | 16182 | 55833724 |
| Hallucination, auditory | 22.27 | 9.99 | 35 | 442126 | 11489 | 55838417 |
| Sleep apnoea syndrome | 22.26 | 9.99 | 117 | 442044 | 25944 | 55823962 |
| Hallucination, visual | 22.19 | 9.99 | 67 | 442094 | 17401 | 55832505 |
| Cerebral infarction | 22.17 | 9.99 | 96 | 442065 | 22409 | 55827497 |
| Therapeutic response decreased | 22.15 | 9.99 | 557 | 441604 | 52201 | 55797705 |
| Infusion site pain | 21.96 | 9.99 | 47 | 442114 | 13715 | 55836191 |
| Diabetes mellitus | 21.93 | 9.99 | 287 | 441874 | 52448 | 55797458 |
| Leukocytosis | 21.93 | 9.99 | 104 | 442057 | 23687 | 55826219 |
| Body temperature decreased | 21.83 | 9.99 | 228 | 441933 | 17880 | 55832026 |
| Uterine perforation | 21.71 | 9.99 | 12 | 442149 | 6493 | 55843413 |
| Skin papilloma | 21.63 | 9.99 | 81 | 442080 | 4408 | 55845498 |
| Loose body in joint | 21.58 | 9.99 | 37 | 442124 | 1228 | 55848678 |
| Placental disorder | 21.58 | 9.99 | 40 | 442121 | 1413 | 55848493 |
| Oedema peripheral | 21.55 | 9.99 | 1112 | 441049 | 170142 | 55679764 |
| Breast cancer stage I | 21.52 | 9.99 | 11 | 442150 | 6219 | 55843687 |
| Haematoma | 21.49 | 9.99 | 155 | 442006 | 31864 | 55818042 |
| Myocarditis | 21.12 | 9.99 | 23 | 442138 | 8835 | 55841071 |
| Neck mass | 21.10 | 9.99 | 67 | 442094 | 3353 | 55846553 |
| Colitis | 21.10 | 9.99 | 218 | 441943 | 41593 | 55808313 |
| General physical health deterioration | 20.88 | 9.99 | 1578 | 440583 | 168432 | 55681474 |
| Mobility decreased | 20.80 | 9.99 | 964 | 441197 | 98027 | 55751879 |
| Myopathy | 20.72 | 9.99 | 28 | 442133 | 9784 | 55840122 |
| Haemoptysis | 20.65 | 9.99 | 123 | 442038 | 26437 | 55823469 |
| Polyhydramnios | 20.62 | 9.99 | 49 | 442112 | 2066 | 55847840 |
| Complication of device removal | 20.60 | 9.99 | 5 | 442156 | 4499 | 55845407 |
| Aspergillus infection | 20.59 | 9.99 | 17 | 442144 | 7448 | 55842458 |
| Pemphigoid | 20.49 | 9.99 | 12 | 442149 | 6288 | 55843618 |
| Erythema multiforme | 20.45 | 9.99 | 27 | 442134 | 9527 | 55840379 |
| Cholecystitis chronic | 20.40 | 9.99 | 28 | 442133 | 9720 | 55840186 |
| Clostridium difficile colitis | 20.30 | 9.99 | 77 | 442084 | 18661 | 55831245 |
| Bronchopulmonary aspergillosis | 20.22 | 9.99 | 21 | 442140 | 8243 | 55841663 |
| Acidosis | 20.19 | 9.99 | 32 | 442129 | 10469 | 55839437 |
| Paradoxical drug reaction | 20.10 | 9.99 | 3 | 442158 | 3817 | 55846089 |
| Hypertransaminasaemia | 20.06 | 9.99 | 6 | 442155 | 4701 | 55845205 |
| Facet joint syndrome | 20.02 | 9.99 | 105 | 442056 | 6612 | 55843294 |
| Lip dry | 19.92 | 9.99 | 138 | 442023 | 9602 | 55840304 |
| Hot flush | 19.91 | 9.99 | 253 | 441908 | 46473 | 55803433 |
| Hypophagia | 19.76 | 9.99 | 139 | 442022 | 28737 | 55821169 |
| Rotator cuff repair | 19.75 | 9.99 | 45 | 442116 | 1845 | 55848061 |
| Ketoacidosis | 19.69 | 9.99 | 4 | 442157 | 4071 | 55845835 |
| Malignant melanoma | 19.68 | 9.99 | 148 | 442013 | 10571 | 55839335 |
| Pulmonary congestion | 19.63 | 9.99 | 63 | 442098 | 16052 | 55833854 |
| Hereditary angioedema | 19.56 | 9.99 | 15 | 442146 | 6820 | 55843086 |
| Peripheral venous disease | 19.56 | 9.99 | 141 | 442020 | 9938 | 55839968 |
| Epilepsy | 19.53 | 9.99 | 117 | 442044 | 25114 | 55824792 |
| Salivary hypersecretion | 19.51 | 9.99 | 16 | 442145 | 7034 | 55842872 |
| Cardiomyopathy | 19.50 | 9.99 | 64 | 442097 | 16194 | 55833712 |
| Respiration abnormal | 19.42 | 9.99 | 10 | 442151 | 5631 | 55844275 |
| Mood altered | 19.38 | 9.99 | 48 | 442113 | 13307 | 55836599 |
| Swollen tongue | 19.30 | 9.99 | 149 | 442012 | 30175 | 55819731 |
| Pyrexia | 19.27 | 9.99 | 2941 | 439220 | 415832 | 55434074 |
| Rash erythematous | 19.22 | 9.99 | 193 | 441968 | 37028 | 55812878 |
| Hypophosphataemia | 19.19 | 9.99 | 29 | 442132 | 9673 | 55840233 |
| Premature delivery | 19.18 | 9.99 | 309 | 441852 | 26751 | 55823155 |
| Muscle rigidity | 19.14 | 9.99 | 34 | 442127 | 10637 | 55839269 |
| Spinal stenosis | 19.10 | 9.99 | 181 | 441980 | 13833 | 55836073 |
| Exposure to toxic agent | 19.10 | 9.99 | 3 | 442158 | 3675 | 55846231 |
| Blood glucose decreased | 19.06 | 9.99 | 81 | 442080 | 19006 | 55830900 |
| Pericardial effusion | 19.00 | 9.99 | 130 | 442031 | 27045 | 55822861 |
| Hypothyroidism | 18.93 | 9.99 | 200 | 441961 | 37996 | 55811910 |
| Toxic epidermal necrolysis | 18.81 | 9.99 | 99 | 442062 | 21943 | 55827963 |
| Body height below normal | 18.79 | 9.99 | 46 | 442115 | 1977 | 55847929 |
| Skin exfoliation | 18.78 | 9.99 | 192 | 441969 | 36708 | 55813198 |
| Infusion site erythema | 18.73 | 9.99 | 29 | 442132 | 9577 | 55840329 |
| Pathogen resistance | 18.71 | 9.99 | 12 | 442149 | 5988 | 55843918 |
| Lip swelling | 18.70 | 9.99 | 125 | 442036 | 26147 | 55823759 |
| Chills | 18.66 | 9.99 | 639 | 441522 | 101965 | 55747941 |
| Incorrect route of product administration | 18.65 | 9.99 | 95 | 442066 | 21234 | 55828672 |
| Acute chest syndrome | 18.56 | 9.99 | 25 | 442136 | 668 | 55849238 |
| Urinary incontinence | 18.53 | 9.99 | 146 | 442015 | 29439 | 55820467 |
| Mental disorder | 18.51 | 9.99 | 109 | 442052 | 23495 | 55826411 |
| Device breakage | 18.50 | 9.99 | 32 | 442129 | 10115 | 55839791 |
| Temperature regulation disorder | 18.50 | 9.99 | 6 | 442155 | 4462 | 55845444 |
| Lymphoedema | 18.49 | 9.99 | 34 | 442127 | 10496 | 55839410 |
| Infusion site swelling | 18.41 | 9.99 | 21 | 442140 | 7900 | 55842006 |
| Atrial septal defect | 18.24 | 9.99 | 100 | 442061 | 6406 | 55843500 |
| Generalised oedema | 18.15 | 9.99 | 56 | 442105 | 14445 | 55835461 |
| Delusion | 18.14 | 9.99 | 38 | 442123 | 11177 | 55838729 |
| Eating disorder | 18.08 | 9.99 | 71 | 442090 | 17034 | 55832872 |
| Bone marrow failure | 18.00 | 9.99 | 139 | 442022 | 28147 | 55821759 |
| Coronary artery disease | 17.92 | 9.99 | 155 | 442006 | 30641 | 55819265 |
| Malaise | 17.88 | 9.99 | 2575 | 439586 | 365285 | 55484621 |
| Aspiration | 17.86 | 9.99 | 30 | 442131 | 9591 | 55840315 |
| Joint noise | 17.80 | 9.99 | 68 | 442093 | 3736 | 55846170 |
| Affective disorder | 17.76 | 9.99 | 11 | 442150 | 5592 | 55844314 |
| Tubulointerstitial nephritis | 17.72 | 9.99 | 69 | 442092 | 16596 | 55833310 |
| Presyncope | 17.58 | 9.99 | 123 | 442038 | 25459 | 55824447 |
| Klebsiella infection | 17.56 | 9.99 | 21 | 442140 | 7735 | 55842171 |
| Gastroenteritis viral | 17.51 | 9.99 | 241 | 441920 | 20183 | 55829723 |
| Malignant mediastinal neoplasm | 17.49 | 9.99 | 28 | 442133 | 877 | 55849029 |
| Rash maculo-papular | 17.49 | 9.99 | 144 | 442017 | 28763 | 55821143 |
| Foetal anticonvulsant syndrome | 17.44 | 9.99 | 22 | 442139 | 550 | 55849356 |
| Congenital arterial malformation | 17.26 | 9.99 | 17 | 442144 | 320 | 55849586 |
| Wound infection | 17.24 | 9.99 | 189 | 441972 | 15004 | 55834902 |
| Cough | 17.24 | 9.99 | 1783 | 440378 | 258178 | 55591728 |
| Cushingoid | 17.15 | 9.99 | 108 | 442053 | 7276 | 55842630 |
| Cyanosis | 17.11 | 9.99 | 65 | 442096 | 15745 | 55834161 |
| Rhinitis allergic | 17.08 | 9.99 | 25 | 442136 | 8449 | 55841457 |
| Paraesthesia | 17.08 | 9.99 | 844 | 441317 | 129670 | 55720236 |
| Pulmonary tuberculosis | 16.98 | 9.99 | 75 | 442086 | 4401 | 55845505 |
| Bundle branch block left | 16.92 | 9.99 | 15 | 442146 | 6347 | 55843559 |
| Shock haemorrhagic | 16.92 | 9.99 | 28 | 442133 | 9005 | 55840901 |
| Epistaxis | 16.87 | 9.99 | 399 | 441762 | 66624 | 55783282 |
| Hyperprolactinaemia | 16.87 | 9.99 | 4 | 442157 | 3657 | 55846249 |
| Purpura | 16.86 | 9.99 | 35 | 442126 | 10327 | 55839579 |
| Fear of injection | 16.85 | 9.99 | 98 | 442063 | 6417 | 55843489 |
| Synovial disorder | 16.78 | 9.99 | 31 | 442130 | 1092 | 55848814 |
| Visual acuity reduced | 16.63 | 9.99 | 95 | 442066 | 20631 | 55829275 |
| Multiple allergies | 16.62 | 9.99 | 36 | 442125 | 10460 | 55839446 |
| Tendonitis | 16.53 | 9.99 | 216 | 441945 | 17881 | 55832025 |
| Polyuria | 16.51 | 9.99 | 21 | 442140 | 7530 | 55842376 |
| Head injury | 16.50 | 9.99 | 122 | 442039 | 24944 | 55824962 |
| Rebound effect | 16.37 | 9.99 | 5 | 442156 | 3865 | 55846041 |
| Clear cell renal cell carcinoma | 16.35 | 9.99 | 33 | 442128 | 1243 | 55848663 |
| Dermatitis atopic | 16.23 | 9.99 | 25 | 442136 | 8274 | 55841632 |
| Renal injury | 16.23 | 9.99 | 28 | 442133 | 8859 | 55841047 |
| Postoperative wound infection | 16.22 | 9.99 | 127 | 442034 | 9186 | 55840720 |
| Gastrointestinal toxicity | 16.18 | 9.99 | 93 | 442068 | 6063 | 55843843 |
| Anti-cyclic citrullinated peptide antibody | 16.16 | 9.99 | 65 | 442096 | 3658 | 55846248 |
| Anger | 16.13 | 9.99 | 43 | 442118 | 11629 | 55838277 |
| Treatment noncompliance | 16.09 | 9.99 | 171 | 441990 | 32452 | 55817454 |
| Haemorrhage in pregnancy | 16.09 | 9.99 | 40 | 442121 | 1736 | 55848170 |
| Adjustment disorder with depressed mood | 16.07 | 9.99 | 81 | 442080 | 5022 | 55844884 |
| Epstein-Barr virus infection | 16.06 | 9.99 | 21 | 442140 | 7442 | 55842464 |
| Right ventricular failure | 16.05 | 9.99 | 70 | 442091 | 16309 | 55833597 |
| Breast feeding | 16.02 | 9.99 | 26 | 442135 | 824 | 55849082 |
| Oliguria | 15.96 | 9.99 | 26 | 442135 | 8414 | 55841492 |
| Acute myocardial infarction | 15.94 | 9.99 | 157 | 442004 | 30236 | 55819670 |
| Incorrect product administration duration | 15.87 | 9.99 | 36 | 442125 | 10290 | 55839616 |
| Cardiac disorder | 15.85 | 9.99 | 259 | 441902 | 45628 | 55804278 |
| Toxic encephalopathy | 15.80 | 9.99 | 14 | 442147 | 5924 | 55843982 |
| Hyperthyroidism | 15.71 | 9.99 | 53 | 442108 | 13299 | 55836607 |
| Product prescribing error | 15.68 | 9.99 | 112 | 442049 | 23074 | 55826832 |
| Renal tubular necrosis | 15.65 | 9.99 | 39 | 442122 | 10789 | 55839117 |
| Abdominal pain upper | 15.62 | 9.99 | 1197 | 440964 | 177116 | 55672790 |
| Pseudomonas infection | 15.57 | 9.99 | 35 | 442126 | 10036 | 55839870 |
| Off label use | 15.55 | 9.99 | 4007 | 438154 | 552173 | 55297733 |
| Renal disorder | 15.50 | 9.99 | 153 | 442008 | 29452 | 55820454 |
| Scleritis | 15.48 | 9.99 | 64 | 442097 | 3647 | 55846259 |
| Obesity | 15.41 | 9.99 | 255 | 441906 | 22193 | 55827713 |
| Rectal haemorrhage | 15.35 | 9.99 | 231 | 441930 | 41236 | 55808670 |
| Fracture delayed union | 15.35 | 9.99 | 47 | 442114 | 2306 | 55847600 |
| Antibody test positive | 15.34 | 9.99 | 48 | 442113 | 2383 | 55847523 |
| Multiple-drug resistance | 15.32 | 9.99 | 6 | 442155 | 3968 | 55845938 |
| Progressive multifocal leukoencephalopathy | 15.31 | 9.99 | 46 | 442115 | 11967 | 55837939 |
| Sinus bradycardia | 15.26 | 9.99 | 55 | 442106 | 13531 | 55836375 |
| Injection site warmth | 15.18 | 9.99 | 175 | 441986 | 14068 | 55835838 |
| Colitis microscopic | 15.14 | 9.99 | 24 | 442137 | 7851 | 55842055 |
| Restless legs syndrome | 15.09 | 9.99 | 75 | 442086 | 16872 | 55833034 |
| Anuria | 15.01 | 9.99 | 45 | 442116 | 11715 | 55838191 |
| Human antichimeric antibody positive | 15.01 | 9.99 | 36 | 442125 | 1527 | 55848379 |
| Hallucinations, mixed | 15.00 | 9.99 | 8 | 442153 | 4416 | 55845490 |
| Bursitis | 14.97 | 9.99 | 302 | 441859 | 27280 | 55822626 |
| Foetal death | 14.90 | 9.99 | 117 | 442044 | 8470 | 55841436 |
| Amylase increased | 14.88 | 9.99 | 14 | 442147 | 5757 | 55844149 |
| Pulseless electrical activity | 14.88 | 9.99 | 20 | 442141 | 7004 | 55842902 |
| Hemiplegia | 14.88 | 9.99 | 27 | 442134 | 8377 | 55841529 |
| Injection site haematoma | 14.87 | 9.99 | 92 | 442069 | 6160 | 55843746 |
| Taste disorder | 14.82 | 9.99 | 34 | 442127 | 9681 | 55840225 |
| Circulatory collapse | 14.80 | 9.99 | 99 | 442062 | 20704 | 55829202 |
| Dactylitis | 14.80 | 9.99 | 43 | 442118 | 2049 | 55847857 |
| Dysuria | 14.78 | 9.99 | 162 | 441999 | 30567 | 55819339 |
| Exostosis | 14.78 | 9.99 | 181 | 441980 | 14762 | 55835144 |
| Body temperature increased | 14.74 | 9.99 | 185 | 441976 | 34057 | 55815849 |
| Device issue | 14.74 | 9.99 | 101 | 442060 | 21005 | 55828901 |
| Talipes | 14.70 | 9.99 | 34 | 442127 | 1408 | 55848498 |
| Hepatitis acute | 14.66 | 9.99 | 27 | 442134 | 8330 | 55841576 |
| Antinuclear antibody positive | 14.63 | 9.99 | 98 | 442063 | 6743 | 55843163 |
| Mouth ulceration | 14.61 | 9.99 | 320 | 441841 | 29320 | 55820586 |
| Systemic inflammatory response syndrome | 14.58 | 9.99 | 12 | 442149 | 5266 | 55844640 |
| Peripheral sensory neuropathy | 14.54 | 9.99 | 20 | 442141 | 6936 | 55842970 |
| Paranoia | 14.53 | 9.99 | 40 | 442121 | 10704 | 55839202 |
| Infusion site pruritus | 14.47 | 9.99 | 10 | 442151 | 4797 | 55845109 |
| Ankylosing spondylitis | 14.41 | 9.99 | 130 | 442031 | 9800 | 55840106 |
| Labelled drug-drug interaction medication error | 14.32 | 9.99 | 45 | 442116 | 11541 | 55838365 |
| Potentiating drug interaction | 14.31 | 9.99 | 7 | 442154 | 4059 | 55845847 |
| Tumour marker increased | 14.21 | 9.99 | 8 | 442153 | 4285 | 55845621 |
| Catheter site pain | 14.21 | 9.99 | 8 | 442153 | 4285 | 55845621 |
| Gestational hypertension | 14.15 | 9.99 | 45 | 442116 | 2254 | 55847652 |
| Bundle branch block right | 14.13 | 9.99 | 10 | 442151 | 4737 | 55845169 |
| Transplant dysfunction | 14.12 | 9.99 | 10 | 442151 | 4736 | 55845170 |
| Schizoaffective disorder | 14.03 | 9.99 | 3 | 442158 | 2946 | 55846960 |
| Polydipsia | 14.02 | 9.99 | 4 | 442157 | 3231 | 55846675 |
| Pulmonary toxicity | 14.00 | 9.99 | 108 | 442053 | 7775 | 55842131 |
| Personality disorder | 14.00 | 9.99 | 12 | 442149 | 5161 | 55844745 |
| Immunodeficiency | 14.00 | 9.99 | 191 | 441970 | 15966 | 55833940 |
| Product substitution issue | 13.94 | 9.99 | 63 | 442098 | 14536 | 55835370 |
| Vascular device infection | 13.91 | 9.99 | 14 | 442147 | 5576 | 55844330 |
| Stillbirth | 13.88 | 9.99 | 90 | 442071 | 6124 | 55843782 |
| Abnormal dreams | 13.75 | 9.99 | 35 | 442126 | 9614 | 55840292 |
| Visual impairment | 13.75 | 9.99 | 461 | 441700 | 73741 | 55776165 |
| Skin cancer | 13.74 | 9.99 | 133 | 442028 | 10222 | 55839684 |
| Pregnancy with contraceptive device | 13.65 | 9.99 | 8 | 442153 | 4191 | 55845715 |
| Respiratory acidosis | 13.62 | 9.99 | 17 | 442144 | 6146 | 55843760 |
| Product complaint | 13.62 | 9.99 | 47 | 442114 | 11713 | 55838193 |
| Laryngospasm | 13.59 | 9.99 | 3 | 442158 | 2881 | 55847025 |
| Pneumonia viral | 13.58 | 9.99 | 22 | 442139 | 7136 | 55842770 |
| Acute coronary syndrome | 13.49 | 9.99 | 36 | 442125 | 9732 | 55840174 |
| Affect lability | 13.47 | 9.99 | 38 | 442123 | 10087 | 55839819 |
| Herpes zoster | 13.44 | 9.99 | 727 | 441434 | 75162 | 55774744 |
| Drug abuser | 13.42 | 9.99 | 3 | 442158 | 2856 | 55847050 |
| Exomphalos | 13.38 | 9.99 | 19 | 442142 | 534 | 55849372 |
| Trigeminal neuralgia | 13.37 | 9.99 | 5 | 442156 | 3402 | 55846504 |
| Food allergy | 13.37 | 9.99 | 31 | 442130 | 8793 | 55841113 |
| Therapy change | 13.36 | 9.99 | 14 | 442147 | 5474 | 55844432 |
| Oropharyngeal pain | 13.36 | 9.99 | 795 | 441366 | 82993 | 55766913 |
| Troponin increased | 13.36 | 9.99 | 30 | 442131 | 8605 | 55841301 |
| Full blood count abnormal | 13.34 | 9.99 | 138 | 442023 | 26324 | 55823582 |
| Sexual dysfunction | 13.25 | 9.99 | 5 | 442156 | 3383 | 55846523 |
| Fracture | 13.24 | 9.99 | 207 | 441954 | 17811 | 55832095 |
| Middle insomnia | 13.20 | 9.99 | 43 | 442118 | 10907 | 55838999 |
| Ileus | 13.20 | 9.99 | 60 | 442101 | 13822 | 55836084 |
| Catheter management | 13.19 | 9.99 | 3 | 442158 | 2823 | 55847083 |
| Cardiotoxicity | 13.17 | 9.99 | 25 | 442136 | 7625 | 55842281 |
| Haemodialysis | 13.16 | 9.99 | 30 | 442131 | 8561 | 55841345 |
| Bone lesion | 13.06 | 9.99 | 14 | 442147 | 5416 | 55844490 |
| Tinnitus | 13.05 | 9.99 | 162 | 441999 | 29880 | 55820026 |
| Hepatic cytolysis | 13.03 | 9.99 | 43 | 442118 | 10863 | 55839043 |
| Ageusia | 12.96 | 9.99 | 52 | 442109 | 12399 | 55837507 |
| Sleep disorder due to a general medical condition | 12.93 | 9.99 | 33 | 442128 | 9057 | 55840849 |
| Catheter site erythema | 12.89 | 9.99 | 8 | 442153 | 4062 | 55845844 |
| Tongue disorder | 12.88 | 9.99 | 128 | 442033 | 9908 | 55839998 |
| Hepatitis cholestatic | 12.85 | 9.99 | 19 | 442142 | 6395 | 55843511 |
| Plasma cell myeloma recurrent | 12.84 | 9.99 | 3 | 442158 | 2771 | 55847135 |
| Speech disorder developmental | 12.83 | 9.99 | 20 | 442141 | 612 | 55849294 |
| Granuloma skin | 12.75 | 9.99 | 97 | 442064 | 6954 | 55842952 |
| Neonatal respiratory distress syndrome | 12.70 | 9.99 | 49 | 442112 | 2705 | 55847201 |
| Foetal distress syndrome | 12.70 | 9.99 | 30 | 442131 | 1260 | 55848646 |
| Pulmonary alveolar haemorrhage | 12.67 | 9.99 | 9 | 442152 | 4255 | 55845651 |
| Prescribed underdose | 12.64 | 9.99 | 230 | 441931 | 20387 | 55829519 |
| Neutropenic colitis | 12.63 | 9.99 | 3 | 442158 | 2740 | 55847166 |
| Pharyngitis streptococcal | 12.61 | 9.99 | 122 | 442039 | 9376 | 55840530 |
| Cytomegalovirus viraemia | 12.54 | 9.99 | 13 | 442148 | 5107 | 55844799 |
| Atrial flutter | 12.50 | 9.99 | 34 | 442127 | 9135 | 55840771 |
| Ear infection | 12.43 | 9.99 | 328 | 441833 | 30967 | 55818939 |
| Embedded device | 12.43 | 9.99 | 4 | 442157 | 2989 | 55846917 |
| Graft versus host disease in skin | 12.39 | 9.99 | 3 | 442158 | 2704 | 55847202 |
| Somnambulism | 12.39 | 9.99 | 13 | 442148 | 5079 | 55844827 |
| Dermatitis exfoliative | 12.37 | 9.99 | 14 | 442147 | 5285 | 55844621 |
| Ileus paralytic | 12.27 | 9.99 | 9 | 442152 | 4186 | 55845720 |
| Bradykinesia | 12.26 | 9.99 | 12 | 442149 | 4842 | 55845064 |
| Onychomycosis | 12.21 | 9.99 | 91 | 442070 | 6481 | 55843425 |
| Cholestasis of pregnancy | 12.21 | 9.99 | 28 | 442133 | 1153 | 55848753 |
| Rheumatoid lung | 12.21 | 9.99 | 53 | 442108 | 3087 | 55846819 |
| Blood urea increased | 12.18 | 9.99 | 128 | 442033 | 24345 | 55825561 |
| Autism spectrum disorder | 12.17 | 9.99 | 22 | 442139 | 762 | 55849144 |
| Hypocalcaemia | 12.15 | 9.99 | 156 | 442005 | 28604 | 55821302 |
| Inadequate analgesia | 12.15 | 9.99 | 3 | 442158 | 2668 | 55847238 |
| Poor venous access | 12.14 | 9.99 | 149 | 442012 | 12157 | 55837749 |
| Drug screen positive | 12.14 | 9.99 | 6 | 442155 | 3458 | 55846448 |
| Lymphatic fistula | 12.13 | 9.99 | 22 | 442139 | 764 | 55849142 |
| Lung transplant | 12.13 | 9.99 | 4 | 442157 | 2943 | 55846963 |
| Ataxia | 12.11 | 9.99 | 65 | 442096 | 14338 | 55835568 |
| Cervical incompetence | 12.11 | 9.99 | 19 | 442142 | 585 | 55849321 |
| Full blood count decreased | 12.08 | 9.99 | 121 | 442040 | 23228 | 55826678 |
| Graft versus host disease in gastrointestinal tract | 12.07 | 9.99 | 4 | 442157 | 2935 | 55846971 |
| Throat tightness | 12.07 | 9.99 | 115 | 442046 | 22292 | 55827614 |
| Human anti-human antibody test | 12.06 | 9.99 | 16 | 442145 | 421 | 55849485 |
| Induced labour | 12.05 | 9.99 | 24 | 442137 | 895 | 55849011 |
| Acute respiratory distress syndrome | 12.04 | 9.99 | 112 | 442049 | 21814 | 55828092 |
| Chronic obstructive pulmonary disease | 12.02 | 9.99 | 351 | 441810 | 57064 | 55792842 |
| Deep vein thrombosis postoperative | 11.93 | 9.99 | 63 | 442098 | 3978 | 55845928 |
| Colorectal cancer | 11.93 | 9.99 | 6 | 442155 | 3423 | 55846483 |
| Blood parathyroid hormone decreased | 11.89 | 9.99 | 109 | 442052 | 8255 | 55841651 |
| Oral herpes | 11.88 | 9.99 | 249 | 441912 | 22641 | 55827265 |
| Embolism | 11.87 | 9.99 | 25 | 442136 | 7339 | 55842567 |
| Blood iron increased | 11.84 | 9.99 | 31 | 442130 | 1389 | 55848517 |
| Femoral hernia incarcerated | 11.83 | 9.99 | 22 | 442139 | 779 | 55849127 |
| Dialysis | 11.77 | 9.99 | 38 | 442123 | 9664 | 55840242 |
| Electrolyte imbalance | 11.76 | 9.99 | 88 | 442073 | 17945 | 55831961 |
| Intracranial pressure increased | 11.75 | 9.99 | 11 | 442150 | 4534 | 55845372 |
| Lipase increased | 11.72 | 9.99 | 34 | 442127 | 8945 | 55840961 |
| Hypertelorism | 11.69 | 9.99 | 16 | 442145 | 434 | 55849472 |
| Occult blood | 11.65 | 9.99 | 28 | 442133 | 1189 | 55848717 |
| Abortion incomplete | 11.60 | 9.99 | 5 | 442156 | 3122 | 55846784 |
| Eosinophil count increased | 11.51 | 9.99 | 38 | 442123 | 9599 | 55840307 |
| Mental impairment | 11.50 | 9.99 | 56 | 442105 | 12666 | 55837240 |
| Motor dysfunction | 11.50 | 9.99 | 37 | 442124 | 9420 | 55840486 |
| Ear pain | 11.46 | 9.99 | 172 | 441989 | 30718 | 55819188 |
| Immunosuppression | 11.43 | 9.99 | 104 | 442057 | 7860 | 55842046 |
| Post procedural haemorrhage | 11.42 | 9.99 | 26 | 442135 | 7423 | 55842483 |
| Haematemesis | 11.42 | 9.99 | 158 | 442003 | 28600 | 55821306 |
| Forceps delivery | 11.39 | 9.99 | 11 | 442150 | 202 | 55849704 |
| Sickle cell anaemia | 11.36 | 9.99 | 18 | 442143 | 559 | 55849347 |
| Lymphopenia | 11.35 | 9.99 | 81 | 442080 | 16693 | 55833213 |
| Feeling hot | 11.30 | 9.99 | 246 | 441915 | 41541 | 55808365 |
| Wound infection pseudomonas | 11.27 | 9.99 | 29 | 442132 | 1286 | 55848620 |
| Acute pulmonary oedema | 11.26 | 9.99 | 27 | 442134 | 7570 | 55842336 |
| Metabolic encephalopathy | 11.22 | 9.99 | 15 | 442146 | 5265 | 55844641 |
| Joint warmth | 11.22 | 9.99 | 31 | 442130 | 1435 | 55848471 |
| Extra dose administered | 11.18 | 9.99 | 16 | 442145 | 5457 | 55844449 |
| Wrong product administered | 11.17 | 9.99 | 17 | 442144 | 5655 | 55844251 |
| Ulcer | 11.16 | 9.99 | 243 | 441918 | 22242 | 55827664 |
| Coordination abnormal | 11.15 | 9.99 | 56 | 442105 | 12565 | 55837341 |
| Blood phosphorus decreased | 11.15 | 9.99 | 9 | 442152 | 3988 | 55845918 |
| Joint lock | 11.15 | 9.99 | 40 | 442121 | 2132 | 55847774 |
| Blood loss anaemia | 11.14 | 9.99 | 31 | 442130 | 8266 | 55841640 |
| Multiple drug therapy | 11.13 | 9.99 | 4 | 442157 | 2788 | 55847118 |
| Hyperthermia | 11.09 | 9.99 | 31 | 442130 | 8254 | 55841652 |
| Pleuritic pain | 11.08 | 9.99 | 94 | 442067 | 6963 | 55842943 |
| Blood sodium decreased | 11.04 | 9.99 | 117 | 442044 | 22217 | 55827689 |
| Endodontic procedure | 10.99 | 9.99 | 49 | 442112 | 2887 | 55847019 |
| Catatonia | 10.97 | 9.99 | 9 | 442152 | 3955 | 55845951 |
| Nystagmus | 10.96 | 9.99 | 18 | 442143 | 5807 | 55844099 |
| Pulmonary haemorrhage | 10.96 | 9.99 | 23 | 442138 | 6760 | 55843146 |
| Intervertebral disc degeneration | 10.95 | 9.99 | 165 | 441996 | 14089 | 55835817 |
| Hypoventilation | 10.93 | 9.99 | 11 | 442150 | 4381 | 55845525 |
| Macular degeneration | 10.92 | 9.99 | 209 | 441952 | 18699 | 55831207 |
| Chronic graft versus host disease | 10.88 | 9.99 | 6 | 442155 | 3250 | 55846656 |
| Madarosis | 10.87 | 9.99 | 4 | 442157 | 2749 | 55847157 |
| Nail injury | 10.87 | 9.99 | 17 | 442144 | 522 | 55849384 |
| Thrombosis | 10.82 | 9.99 | 370 | 441791 | 59057 | 55790849 |
| Product physical issue | 10.81 | 9.99 | 12 | 442149 | 4570 | 55845336 |
| Erythema | 10.81 | 9.99 | 1066 | 441095 | 154873 | 55695033 |
| Anterior chamber cleavage syndrome | 10.79 | 9.99 | 10 | 442151 | 174 | 55849732 |
| Prescribed overdose | 10.76 | 9.99 | 240 | 441921 | 22056 | 55827850 |
| Therapeutic response unexpected | 10.73 | 9.99 | 84 | 442077 | 16960 | 55832946 |
| Breast cancer stage II | 10.64 | 9.99 | 18 | 442143 | 5740 | 55844166 |
| Bone disorder | 10.61 | 9.99 | 214 | 441947 | 19329 | 55830577 |
| Coronary arterial stent insertion | 10.60 | 9.99 | 4 | 442157 | 2706 | 55847200 |
| Diabetes insipidus | 10.58 | 9.99 | 3 | 442158 | 2434 | 55847472 |
| Abortion threatened | 10.54 | 9.99 | 17 | 442144 | 536 | 55849370 |
| Hyperammonaemia | 10.53 | 9.99 | 14 | 442147 | 4926 | 55844980 |
| Blood pressure inadequately controlled | 10.51 | 9.99 | 12 | 442149 | 4512 | 55845394 |
| Pneumonia | 10.50 | 9.99 | 2943 | 439218 | 404155 | 55445751 |
| Squamous cell carcinoma | 10.49 | 9.99 | 104 | 442057 | 8044 | 55841862 |
| End stage renal disease | 10.49 | 9.99 | 20 | 442141 | 6091 | 55843815 |
| Hepatic necrosis | 10.41 | 9.99 | 16 | 442145 | 5300 | 55844606 |
| Retrognathia | 10.40 | 9.99 | 15 | 442146 | 428 | 55849478 |
| Bacteraemia | 10.33 | 9.99 | 76 | 442085 | 15555 | 55834351 |
| Device deployment issue | 10.31 | 9.99 | 8 | 442153 | 3616 | 55846290 |
| Lupus vulgaris | 10.31 | 9.99 | 36 | 442125 | 1893 | 55848013 |
| Learning disorder | 10.30 | 9.99 | 18 | 442143 | 607 | 55849299 |
| Incoherent | 10.27 | 9.99 | 11 | 442150 | 4258 | 55845648 |
| Tendon disorder | 10.22 | 9.99 | 76 | 442085 | 5409 | 55844497 |
| Breast cancer female | 10.20 | 9.99 | 56 | 442105 | 12282 | 55837624 |
| Hyperuricaemia | 10.19 | 9.99 | 15 | 442146 | 5058 | 55844848 |
| Abortion missed | 10.19 | 9.99 | 32 | 442129 | 1592 | 55848314 |
| Facial paralysis | 10.16 | 9.99 | 62 | 442099 | 13249 | 55836657 |
| Immune thrombocytopenia | 10.14 | 9.99 | 40 | 442121 | 9585 | 55840321 |
| Hypoglycaemic coma | 10.12 | 9.99 | 3 | 442158 | 2364 | 55847542 |
| Panniculitis | 10.07 | 9.99 | 120 | 442041 | 9722 | 55840184 |
| Transaminases increased | 10.06 | 9.99 | 162 | 441999 | 28608 | 55821298 |
| Pancreatic steatosis | 10.06 | 9.99 | 23 | 442138 | 945 | 55848961 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Rheumatoid arthritis | 492.50 | 10.20 | 837 | 147454 | 46972 | 31502081 |
| Foetal exposure during pregnancy | 339.67 | 10.20 | 652 | 147639 | 40224 | 31508829 |
| Drug abuse | 318.92 | 10.20 | 24 | 148267 | 87734 | 31461319 |
| Arthralgia | 236.86 | 10.20 | 1360 | 146931 | 150064 | 31398989 |
| Toxicity to various agents | 235.89 | 10.20 | 302 | 147989 | 181185 | 31367868 |
| Completed suicide | 212.68 | 10.20 | 81 | 148210 | 91433 | 31457620 |
| Psoriatic arthropathy | 159.98 | 10.20 | 313 | 147978 | 19570 | 31529483 |
| Dysmorphism | 136.49 | 10.20 | 114 | 148177 | 2958 | 31546095 |
| Joint swelling | 125.41 | 10.20 | 539 | 147752 | 52892 | 31496161 |
| Drug interaction | 118.65 | 10.20 | 537 | 147754 | 208006 | 31341047 |
| Sickle cell anaemia with crisis | 117.15 | 10.20 | 102 | 148189 | 2805 | 31546248 |
| Premature baby | 102.49 | 10.20 | 247 | 148044 | 17819 | 31531234 |
| Intentional overdose | 92.22 | 10.20 | 39 | 148252 | 41350 | 31507703 |
| Musculoskeletal stiffness | 90.96 | 10.20 | 409 | 147882 | 40916 | 31508137 |
| Enthesopathy | 88.90 | 10.20 | 105 | 148186 | 4182 | 31544871 |
| Exposure during pregnancy | 82.48 | 10.20 | 146 | 148145 | 8452 | 31540601 |
| Blood pressure fluctuation | 82.44 | 10.20 | 264 | 148027 | 22472 | 31526581 |
| Tenosynovitis | 78.96 | 10.20 | 98 | 148193 | 4112 | 31544941 |
| Speech disorder developmental | 75.59 | 10.20 | 69 | 148222 | 2022 | 31547031 |
| Acute kidney injury | 73.42 | 10.20 | 897 | 147394 | 278817 | 31270236 |
| Synovitis | 71.90 | 10.20 | 170 | 148121 | 12113 | 31536940 |
| Neonatal respiratory distress syndrome | 70.58 | 10.20 | 89 | 148202 | 3796 | 31545257 |
| Death | 67.80 | 10.20 | 1234 | 147057 | 359335 | 31189718 |
| Atrial septal defect | 66.93 | 10.20 | 118 | 148173 | 6809 | 31542244 |
| Pain | 66.21 | 10.20 | 1234 | 147057 | 185525 | 31363528 |
| Product use in unapproved indication | 65.93 | 10.20 | 240 | 148051 | 98931 | 31450122 |
| Hypospadias | 64.09 | 10.20 | 76 | 148215 | 3040 | 31546013 |
| Foetal anticonvulsant syndrome | 63.92 | 10.20 | 49 | 148242 | 1120 | 31547933 |
| Nasopharyngitis | 63.16 | 10.20 | 509 | 147782 | 62736 | 31486317 |
| Suicide attempt | 63.14 | 10.20 | 49 | 148242 | 37199 | 31511854 |
| C-reactive protein abnormal | 60.90 | 10.20 | 121 | 148170 | 7648 | 31541405 |
| Overdose | 59.55 | 10.20 | 200 | 148091 | 84464 | 31464589 |
| Arthropathy | 58.22 | 10.20 | 245 | 148046 | 23806 | 31525247 |
| Maternal exposure during pregnancy | 58.07 | 10.20 | 89 | 148202 | 4567 | 31544486 |
| Maternal drugs affecting foetus | 57.94 | 10.20 | 81 | 148210 | 3822 | 31545231 |
| Cryptorchism | 57.50 | 10.20 | 58 | 148233 | 1929 | 31547124 |
| Autism spectrum disorder | 56.19 | 10.20 | 60 | 148231 | 2135 | 31546918 |
| Small for dates baby | 54.48 | 10.20 | 76 | 148215 | 3579 | 31545474 |
| Serotonin syndrome | 53.99 | 10.20 | 11 | 148280 | 18762 | 31530291 |
| Hypoglycaemia neonatal | 53.37 | 10.20 | 53 | 148238 | 1729 | 31547324 |
| Blood pressure systolic increased | 53.24 | 10.20 | 206 | 148085 | 19264 | 31529789 |
| Arthritis | 52.90 | 10.20 | 261 | 148030 | 27124 | 31521929 |
| Low birth weight baby | 51.59 | 10.20 | 106 | 148185 | 6864 | 31542189 |
| Drug resistance | 50.81 | 10.20 | 23 | 148268 | 23430 | 31525623 |
| Coma | 50.74 | 10.20 | 71 | 148220 | 41079 | 31507974 |
| Learning disorder | 50.71 | 10.20 | 41 | 148250 | 1015 | 31548038 |
| Tongue disorder | 50.47 | 10.20 | 87 | 148204 | 4930 | 31544123 |
| Psoriasis | 49.94 | 10.20 | 382 | 147909 | 46337 | 31502716 |
| Alanine aminotransferase abnormal | 48.31 | 10.20 | 75 | 148216 | 3892 | 31545161 |
| Ventricular septal defect | 48.29 | 10.20 | 72 | 148219 | 3605 | 31545448 |
| Maternal exposure during breast feeding | 48.12 | 10.20 | 47 | 148244 | 1502 | 31547551 |
| Rheumatoid nodule | 46.46 | 10.20 | 60 | 148231 | 2621 | 31546432 |
| Rhabdomyolysis | 46.22 | 10.20 | 148 | 148143 | 63433 | 31485620 |
| Hepatic function abnormal | 45.20 | 10.20 | 77 | 148214 | 41145 | 31507908 |
| Palmar-plantar erythrodysaesthesia syndrome | 44.68 | 10.20 | 9 | 148282 | 15474 | 31533579 |
| Syndactyly | 44.56 | 10.20 | 35 | 148256 | 830 | 31548223 |
| Foot deformity | 44.45 | 10.20 | 74 | 148217 | 4075 | 31544978 |
| Drug intolerance | 43.17 | 10.20 | 402 | 147889 | 51631 | 31497422 |
| Infusion related reaction | 42.79 | 10.20 | 377 | 147914 | 47678 | 31501375 |
| Pulmonary fibrosis | 42.12 | 10.20 | 172 | 148119 | 16488 | 31532565 |
| Febrile neutropenia | 42.02 | 10.20 | 366 | 147925 | 121483 | 31427570 |
| Drug reaction with eosinophilia and systemic symptoms | 42.02 | 10.20 | 47 | 148244 | 29971 | 31519082 |
| Blood pressure diastolic abnormal | 41.34 | 10.20 | 70 | 148221 | 3909 | 31545144 |
| Bradycardia | 40.82 | 10.20 | 176 | 148115 | 69151 | 31479902 |
| Drug dependence | 40.48 | 10.20 | 28 | 148263 | 22551 | 31526502 |
| Lower respiratory tract infection | 40.35 | 10.20 | 248 | 148043 | 27989 | 31521064 |
| Developmental delay | 40.08 | 10.20 | 55 | 148236 | 2550 | 31546503 |
| Basal cell carcinoma | 39.29 | 10.20 | 179 | 148112 | 18000 | 31531053 |
| Blood pressure systolic abnormal | 38.49 | 10.20 | 59 | 148232 | 3028 | 31546025 |
| Osteoarthritis | 37.02 | 10.20 | 182 | 148109 | 18885 | 31530168 |
| Pancytopenia | 37.01 | 10.20 | 594 | 147697 | 86722 | 31462331 |
| C-reactive protein increased | 36.97 | 10.20 | 369 | 147922 | 48281 | 31500772 |
| Talipes | 36.28 | 10.20 | 44 | 148247 | 1802 | 31547251 |
| Exposure via breast milk | 36.02 | 10.20 | 44 | 148247 | 1816 | 31547237 |
| Joint laxity | 36.00 | 10.20 | 23 | 148268 | 388 | 31548665 |
| Intellectual disability | 35.79 | 10.20 | 36 | 148255 | 1193 | 31547860 |
| Blood pressure increased | 35.36 | 10.20 | 546 | 147745 | 79087 | 31469966 |
| Tendonitis | 35.33 | 10.20 | 104 | 148187 | 8454 | 31540599 |
| Pain in extremity | 35.13 | 10.20 | 750 | 147541 | 115453 | 31433600 |
| Hand deformity | 34.88 | 10.20 | 56 | 148235 | 2991 | 31546062 |
| Angioedema | 33.99 | 10.20 | 66 | 148225 | 33552 | 31515501 |
| Haemoglobin decreased | 33.98 | 10.20 | 727 | 147564 | 111948 | 31437105 |
| Renal failure | 33.96 | 10.20 | 391 | 147900 | 122939 | 31426114 |
| Suicidal ideation | 33.84 | 10.20 | 75 | 148216 | 36331 | 31512722 |
| Disease progression | 33.78 | 10.20 | 266 | 148025 | 90198 | 31458855 |
| Cytomegalovirus infection | 33.16 | 10.20 | 40 | 148251 | 24667 | 31524386 |
| Foetal growth restriction | 33.06 | 10.20 | 62 | 148229 | 3753 | 31545300 |
| Joint effusion | 32.93 | 10.20 | 69 | 148222 | 4530 | 31544523 |
| Congenital hand malformation | 32.85 | 10.20 | 25 | 148266 | 565 | 31548488 |
| Heart rate decreased | 32.39 | 10.20 | 235 | 148056 | 28031 | 31521022 |
| Jaundice neonatal | 32.34 | 10.20 | 35 | 148256 | 1265 | 31547788 |
| Peripheral swelling | 31.94 | 10.20 | 470 | 147821 | 67395 | 31481658 |
| Blood pressure diastolic decreased | 31.77 | 10.20 | 96 | 148195 | 7917 | 31541136 |
| Hypermobility syndrome | 31.17 | 10.20 | 20 | 148271 | 340 | 31548713 |
| Cardiac failure | 31.04 | 10.20 | 255 | 148036 | 85698 | 31463355 |
| Plagiocephaly | 30.64 | 10.20 | 23 | 148268 | 509 | 31548544 |
| Lactic acidosis | 30.34 | 10.20 | 65 | 148226 | 31872 | 31517181 |
| Language disorder | 29.95 | 10.20 | 43 | 148248 | 2080 | 31546973 |
| Polyarthritis | 29.53 | 10.20 | 63 | 148228 | 4189 | 31544864 |
| Knee arthroplasty | 29.30 | 10.20 | 82 | 148209 | 6476 | 31542577 |
| Psychotic disorder | 28.97 | 10.20 | 37 | 148254 | 22256 | 31526797 |
| Drug withdrawal syndrome | 28.92 | 10.20 | 27 | 148264 | 18723 | 31530330 |
| Respiratory arrest | 28.82 | 10.20 | 49 | 148242 | 26208 | 31522845 |
| Intentional product misuse | 28.52 | 10.20 | 87 | 148204 | 37864 | 31511189 |
| Body temperature decreased | 27.78 | 10.20 | 119 | 148172 | 11651 | 31537402 |
| Large for dates baby | 27.64 | 10.20 | 27 | 148264 | 863 | 31548190 |
| Immune reconstitution inflammatory syndrome | 27.63 | 10.20 | 3 | 148288 | 8175 | 31540878 |
| Dysgraphia | 27.61 | 10.20 | 42 | 148249 | 2141 | 31546912 |
| Selective eating disorder | 27.50 | 10.20 | 37 | 148254 | 1683 | 31547370 |
| Astigmatism | 27.16 | 10.20 | 29 | 148262 | 1032 | 31548021 |
| Delirium | 27.00 | 10.20 | 101 | 148190 | 41320 | 31507733 |
| Knee deformity | 26.04 | 10.20 | 22 | 148269 | 580 | 31548473 |
| Hyperbilirubinaemia neonatal | 25.88 | 10.20 | 24 | 148267 | 718 | 31548335 |
| Agitation | 25.86 | 10.20 | 148 | 148143 | 54021 | 31495032 |
| Hypoglycaemia | 25.52 | 10.20 | 137 | 148154 | 50809 | 31498244 |
| Hypotonia neonatal | 25.40 | 10.20 | 31 | 148260 | 1278 | 31547775 |
| Inflammation | 25.09 | 10.20 | 203 | 148088 | 25038 | 31524015 |
| Red blood cell sedimentation rate increased | 25.05 | 10.20 | 91 | 148200 | 8255 | 31540798 |
| Anal fistula | 24.60 | 10.20 | 63 | 148228 | 4720 | 31544333 |
| Off label use | 24.53 | 10.20 | 1352 | 146939 | 345922 | 31203131 |
| Serum ferritin increased | 24.50 | 10.20 | 71 | 148220 | 5721 | 31543332 |
| Poisoning | 24.44 | 10.20 | 9 | 148282 | 10382 | 31538671 |
| Altered state of consciousness | 24.31 | 10.20 | 38 | 148253 | 21013 | 31528040 |
| Motor developmental delay | 24.29 | 10.20 | 22 | 148269 | 638 | 31548415 |
| Grip strength decreased | 24.18 | 10.20 | 44 | 148247 | 2602 | 31546451 |
| Caesarean section | 24.13 | 10.20 | 37 | 148254 | 1899 | 31547154 |
| Somnolence | 24.08 | 10.20 | 324 | 147967 | 99121 | 31449932 |
| Cardiac arrest | 23.86 | 10.20 | 284 | 148007 | 88778 | 31460275 |
| Hyperglycaemia | 23.73 | 10.20 | 89 | 148202 | 36387 | 31512666 |
| Musculoskeletal pain | 23.51 | 10.20 | 228 | 148063 | 29600 | 31519453 |
| Strabismus | 23.35 | 10.20 | 33 | 148258 | 1573 | 31547480 |
| Substance abuse | 23.25 | 10.20 | 3 | 148288 | 7155 | 31541898 |
| Pathogen resistance | 23.22 | 10.20 | 6 | 148285 | 8695 | 31540358 |
| Sedation | 23.10 | 10.20 | 33 | 148258 | 18932 | 31530121 |
| Nasal disorder | 22.82 | 10.20 | 34 | 148257 | 1701 | 31547352 |
| Depressed level of consciousness | 22.71 | 10.20 | 98 | 148193 | 38503 | 31510550 |
| Loss of personal independence in daily activities | 22.68 | 10.20 | 217 | 148074 | 28071 | 31520982 |
| Blood creatine phosphokinase increased | 22.65 | 10.20 | 110 | 148181 | 41864 | 31507189 |
| Rash maculo-papular | 22.28 | 10.20 | 55 | 148236 | 25664 | 31523389 |
| Drug withdrawal syndrome neonatal | 22.27 | 10.20 | 50 | 148241 | 3442 | 31545611 |
| Skin cancer | 22.24 | 10.20 | 95 | 148196 | 9290 | 31539763 |
| Diaphragmatic disorder | 22.11 | 10.20 | 27 | 148264 | 1114 | 31547939 |
| Hydrocele | 22.09 | 10.20 | 36 | 148255 | 1947 | 31547106 |
| Otitis media | 22.03 | 10.20 | 42 | 148249 | 2574 | 31546479 |
| Urticaria | 21.98 | 10.20 | 168 | 148123 | 57349 | 31491704 |
| Dyspraxia | 21.68 | 10.20 | 17 | 148274 | 402 | 31548651 |
| Acute hepatic failure | 21.68 | 10.20 | 17 | 148274 | 12842 | 31536211 |
| Shock | 21.58 | 10.20 | 46 | 148245 | 22599 | 31526454 |
| Therapeutic product effect decreased | 21.26 | 10.20 | 234 | 148057 | 31388 | 31517665 |
| Joint stiffness | 21.15 | 10.20 | 98 | 148193 | 9923 | 31539130 |
| Neuroleptic malignant syndrome | 20.90 | 10.20 | 29 | 148262 | 16840 | 31532213 |
| Cleft lip | 20.82 | 10.20 | 15 | 148276 | 311 | 31548742 |
| Intentional self-injury | 20.74 | 10.20 | 19 | 148272 | 13296 | 31535757 |
| Plasma cell myeloma | 20.73 | 10.20 | 167 | 148124 | 56364 | 31492689 |
| Blood pressure diastolic increased | 20.66 | 10.20 | 55 | 148236 | 4218 | 31544835 |
| Dyslexia | 20.49 | 10.20 | 15 | 148276 | 319 | 31548734 |
| Foetal disorder | 20.49 | 10.20 | 22 | 148269 | 788 | 31548265 |
| Blood parathyroid hormone decreased | 20.47 | 10.20 | 28 | 148263 | 1294 | 31547759 |
| Poor venous access | 20.22 | 10.20 | 53 | 148238 | 4027 | 31545026 |
| Bronchiolitis | 20.13 | 10.20 | 43 | 148248 | 2861 | 31546192 |
| Behaviour disorder | 20.06 | 10.20 | 55 | 148236 | 4292 | 31544761 |
| Multiple organ dysfunction syndrome | 20.03 | 10.20 | 213 | 148078 | 67990 | 31481063 |
| Agitation neonatal | 19.97 | 10.20 | 25 | 148266 | 1058 | 31547995 |
| Weight decreased | 19.92 | 10.20 | 927 | 147364 | 159025 | 31390028 |
| Vitamin D deficiency | 19.81 | 10.20 | 67 | 148224 | 5865 | 31543188 |
| Post procedural infection | 19.67 | 10.20 | 56 | 148235 | 4467 | 31544586 |
| Medical device implantation | 19.61 | 10.20 | 19 | 148272 | 601 | 31548452 |
| Red blood cell sedimentation rate | 19.24 | 10.20 | 24 | 148267 | 1012 | 31548041 |
| Arthritis bacterial | 19.16 | 10.20 | 56 | 148235 | 4534 | 31544519 |
| Umbilical hernia | 19.13 | 10.20 | 53 | 148238 | 4161 | 31544892 |
| Haematocrit decreased | 19.10 | 10.20 | 220 | 148071 | 29841 | 31519212 |
| Radiation inflammation | 19.09 | 10.20 | 18 | 148273 | 550 | 31548503 |
| Microcephaly | 18.96 | 10.20 | 21 | 148270 | 779 | 31548274 |
| Congenital anomaly | 18.77 | 10.20 | 27 | 148264 | 1308 | 31547745 |
| Wound | 18.75 | 10.20 | 114 | 148177 | 12814 | 31536239 |
| Lacrimal disorder | 18.68 | 10.20 | 14 | 148277 | 309 | 31548744 |
| Joint range of motion decreased | 18.63 | 10.20 | 71 | 148220 | 6590 | 31542463 |
| No adverse event | 18.59 | 10.20 | 40 | 148251 | 19585 | 31529468 |
| Oxygen saturation decreased | 18.55 | 10.20 | 328 | 147963 | 48787 | 31500266 |
| Oropharyngeal pain | 18.50 | 10.20 | 227 | 148064 | 31256 | 31517797 |
| Patent ductus arteriosus | 18.47 | 10.20 | 44 | 148247 | 3149 | 31545904 |
| Congenital bladder anomaly | 18.44 | 10.20 | 13 | 148278 | 260 | 31548793 |
| Limb reduction defect | 18.40 | 10.20 | 13 | 148278 | 261 | 31548792 |
| Infective pulmonary exacerbation of cystic fibrosis | 18.23 | 10.20 | 4 | 148287 | 6480 | 31542573 |
| Weight decrease neonatal | 18.22 | 10.20 | 14 | 148277 | 321 | 31548732 |
| Ear infection | 18.12 | 10.20 | 86 | 148205 | 8795 | 31540258 |
| Drug ineffective for unapproved indication | 17.92 | 10.20 | 35 | 148256 | 17755 | 31531298 |
| Ear disorder | 17.84 | 10.20 | 27 | 148264 | 1370 | 31547683 |
| Respiratory disorder neonatal | 17.84 | 10.20 | 28 | 148263 | 1467 | 31547586 |
| Congenital foot malformation | 17.80 | 10.20 | 15 | 148276 | 394 | 31548659 |
| Multiple congenital abnormalities | 17.78 | 10.20 | 17 | 148274 | 529 | 31548524 |
| Vitamin B12 deficiency | 17.73 | 10.20 | 46 | 148245 | 3473 | 31545580 |
| Constipation | 17.71 | 10.20 | 443 | 147848 | 123548 | 31425505 |
| Renal aplasia | 17.64 | 10.20 | 19 | 148272 | 683 | 31548370 |
| Granuloma skin | 17.58 | 10.20 | 24 | 148267 | 1107 | 31547946 |
| Hallucination | 17.52 | 10.20 | 136 | 148155 | 46274 | 31502779 |
| Lung neoplasm malignant | 17.49 | 10.20 | 133 | 148158 | 16097 | 31532956 |
| Electrocardiogram QT prolonged | 17.48 | 10.20 | 105 | 148186 | 37882 | 31511171 |
| Scoliosis | 17.46 | 10.20 | 38 | 148253 | 2561 | 31546492 |
| Ankyloglossia congenital | 17.46 | 10.20 | 13 | 148278 | 284 | 31548769 |
| Juvenile idiopathic arthritis | 17.36 | 10.20 | 30 | 148261 | 1703 | 31547350 |
| Attention deficit hyperactivity disorder | 17.20 | 10.20 | 36 | 148255 | 2362 | 31546691 |
| Neurotoxicity | 17.16 | 10.20 | 31 | 148260 | 16195 | 31532858 |
| Haemangioma congenital | 17.13 | 10.20 | 16 | 148275 | 483 | 31548570 |
| Infection | 17.05 | 10.20 | 503 | 147788 | 81428 | 31467625 |
| Hepatic failure | 16.90 | 10.20 | 87 | 148204 | 32615 | 31516438 |
| Psychomotor retardation | 16.89 | 10.20 | 43 | 148248 | 3209 | 31545844 |
| Septic arthritis staphylococcal | 16.86 | 10.20 | 16 | 148275 | 493 | 31548560 |
| Haemangioma | 16.75 | 10.20 | 30 | 148261 | 1752 | 31547301 |
| Malignant melanoma | 16.73 | 10.20 | 76 | 148215 | 7631 | 31541422 |
| Polydactyly | 16.57 | 10.20 | 24 | 148267 | 1170 | 31547883 |
| Spinal disorder | 16.53 | 10.20 | 48 | 148243 | 3872 | 31545181 |
| Pharyngeal disorder | 16.44 | 10.20 | 18 | 148273 | 659 | 31548394 |
| Diabetic ketoacidosis | 16.39 | 10.20 | 34 | 148257 | 16871 | 31532182 |
| Respiratory rate increased | 16.37 | 10.20 | 86 | 148205 | 9159 | 31539894 |
| C-reactive protein decreased | 16.36 | 10.20 | 30 | 148261 | 1785 | 31547268 |
| Arthrodesis | 16.28 | 10.20 | 15 | 148276 | 445 | 31548608 |
| Back disorder | 16.27 | 10.20 | 64 | 148227 | 6029 | 31543024 |
| Renal impairment | 16.27 | 10.20 | 295 | 147996 | 86054 | 31462999 |
| Pyrexia | 16.24 | 10.20 | 1213 | 147078 | 302627 | 31246426 |
| Finger deformity | 16.10 | 10.20 | 24 | 148267 | 1201 | 31547852 |
| Bradycardia neonatal | 16.06 | 10.20 | 21 | 148270 | 929 | 31548124 |
| Arnold-Chiari malformation | 15.97 | 10.20 | 13 | 148278 | 325 | 31548728 |
| Toxic epidermal necrolysis | 15.95 | 10.20 | 43 | 148248 | 19481 | 31529572 |
| Foetal distress syndrome | 15.93 | 10.20 | 22 | 148269 | 1026 | 31548027 |
| Pectus excavatum | 15.78 | 10.20 | 11 | 148280 | 216 | 31548837 |
| Tuberculosis | 15.75 | 10.20 | 79 | 148212 | 8262 | 31540791 |
| Neck mass | 15.57 | 10.20 | 27 | 148264 | 1537 | 31547516 |
| Immunodeficiency | 15.56 | 10.20 | 53 | 148238 | 4656 | 31544397 |
| Hypertelorism | 15.52 | 10.20 | 16 | 148275 | 546 | 31548507 |
| Localised infection | 15.30 | 10.20 | 123 | 148168 | 15142 | 31533911 |
| Oesophageal fibrosis | 15.29 | 10.20 | 10 | 148281 | 176 | 31548877 |
| Tooth malformation | 15.05 | 10.20 | 10 | 148281 | 181 | 31548872 |
| Foetal heart rate deceleration abnormality | 15.01 | 10.20 | 15 | 148276 | 493 | 31548560 |
| Venoocclusive liver disease | 14.95 | 10.20 | 8 | 148283 | 7404 | 31541649 |
| Cerebral haemorrhage | 14.94 | 10.20 | 91 | 148200 | 32721 | 31516332 |
| Maternal exposure timing unspecified | 14.79 | 10.20 | 13 | 148278 | 362 | 31548691 |
| Hepatic enzyme increased | 14.71 | 10.20 | 243 | 148048 | 35665 | 31513388 |
| Aggression | 14.68 | 10.20 | 108 | 148183 | 37183 | 31511870 |
| Inguinal hernia | 14.56 | 10.20 | 68 | 148223 | 6907 | 31542146 |
| Malignant neoplasm progression | 14.54 | 10.20 | 271 | 148020 | 78727 | 31470326 |
| Cellulitis | 14.51 | 10.20 | 310 | 147981 | 47708 | 31501345 |
| Proteinuria | 14.40 | 10.20 | 36 | 148255 | 16727 | 31532326 |
| Upper respiratory tract infection | 14.32 | 10.20 | 205 | 148086 | 29217 | 31519836 |
| Unresponsive to stimuli | 14.27 | 10.20 | 67 | 148224 | 25733 | 31523320 |
| Hepatitis E antibody positive | 14.18 | 10.20 | 11 | 148280 | 256 | 31548797 |
| Arthritis infective | 14.17 | 10.20 | 38 | 148253 | 2927 | 31546126 |
| Crohn's disease | 14.16 | 10.20 | 47 | 148244 | 4074 | 31544979 |
| Blood folate decreased | 14.16 | 10.20 | 17 | 148274 | 689 | 31548364 |
| Haemolysis | 14.09 | 10.20 | 69 | 148222 | 7147 | 31541906 |
| Hernia pain | 13.96 | 10.20 | 11 | 148280 | 262 | 31548791 |
| Respiratory failure | 13.80 | 10.20 | 365 | 147926 | 101084 | 31447969 |
| Injection site pain | 13.69 | 10.20 | 233 | 148058 | 34401 | 31514652 |
| Synovial cyst | 13.66 | 10.20 | 30 | 148261 | 2035 | 31547018 |
| Colorectal cancer | 13.54 | 10.20 | 3 | 148288 | 4826 | 31544227 |
| Irritability | 13.53 | 10.20 | 58 | 148233 | 22831 | 31526222 |
| Vascular insufficiency | 13.51 | 10.20 | 12 | 148279 | 339 | 31548714 |
| Cholelithiasis | 13.49 | 10.20 | 145 | 148146 | 19334 | 31529719 |
| Spina bifida | 13.42 | 10.20 | 12 | 148279 | 342 | 31548711 |
| Blood insulin increased | 13.28 | 10.20 | 12 | 148279 | 347 | 31548706 |
| Anaphylactic shock | 13.26 | 10.20 | 29 | 148262 | 14116 | 31534937 |
| Anal atresia | 13.21 | 10.20 | 11 | 148280 | 284 | 31548769 |
| Hepatitis E virus test positive | 13.21 | 10.20 | 11 | 148280 | 284 | 31548769 |
| Aspergillus infection | 13.13 | 10.20 | 21 | 148270 | 11507 | 31537546 |
| Abnormal behaviour | 13.11 | 10.20 | 62 | 148229 | 23766 | 31525287 |
| Nodule | 13.02 | 10.20 | 57 | 148234 | 5633 | 31543420 |
| Neutropenia neonatal | 13.01 | 10.20 | 16 | 148275 | 665 | 31548388 |
| Panniculitis | 12.92 | 10.20 | 27 | 148264 | 1769 | 31547284 |
| Wrong technique in product usage process | 12.92 | 10.20 | 97 | 148194 | 33246 | 31515807 |
| Osteonecrosis of jaw | 12.92 | 10.20 | 39 | 148252 | 17032 | 31532021 |
| Developmental coordination disorder | 12.90 | 10.20 | 9 | 148282 | 177 | 31548876 |
| Mouth ulceration | 12.89 | 10.20 | 91 | 148200 | 10757 | 31538296 |
| Pleural fibrosis | 12.88 | 10.20 | 23 | 148268 | 1340 | 31547713 |
| Ear malformation | 12.77 | 10.20 | 11 | 148280 | 298 | 31548755 |
| Sexual dysfunction | 12.70 | 10.20 | 6 | 148285 | 5962 | 31543091 |
| Contraindicated product administered | 12.69 | 10.20 | 145 | 148146 | 19627 | 31529426 |
| Heart rate irregular | 12.66 | 10.20 | 112 | 148179 | 14177 | 31534876 |
| Low set ears | 12.65 | 10.20 | 13 | 148278 | 442 | 31548611 |
| Maternal exposure before pregnancy | 12.64 | 10.20 | 16 | 148275 | 685 | 31548368 |
| Respiratory depression | 12.59 | 10.20 | 31 | 148260 | 14479 | 31534574 |
| Steatorrhoea | 12.58 | 10.20 | 16 | 148275 | 688 | 31548365 |
| Emphysema | 12.53 | 10.20 | 78 | 148213 | 8840 | 31540213 |
| Gastrointestinal infection | 12.48 | 10.20 | 50 | 148241 | 4750 | 31544303 |
| Injection site haemorrhage | 12.48 | 10.20 | 79 | 148212 | 9006 | 31540047 |
| Palindromic rheumatism | 12.47 | 10.20 | 9 | 148282 | 187 | 31548866 |
| Educational problem | 12.39 | 10.20 | 14 | 148277 | 531 | 31548522 |
| Hypermetropia | 12.39 | 10.20 | 13 | 148278 | 453 | 31548600 |
| Congenital hydronephrosis | 12.32 | 10.20 | 16 | 148275 | 703 | 31548350 |
| Hypertriglyceridaemia | 12.30 | 10.20 | 11 | 148280 | 7787 | 31541266 |
| Peripheral artery thrombosis | 12.28 | 10.20 | 30 | 148261 | 2182 | 31546871 |
| Gangrene neonatal | 12.27 | 10.20 | 9 | 148282 | 192 | 31548861 |
| Blood test abnormal | 12.19 | 10.20 | 59 | 148232 | 6082 | 31542971 |
| Asthma | 12.14 | 10.20 | 134 | 148157 | 42477 | 31506576 |
| Lung cancer metastatic | 12.05 | 10.20 | 33 | 148258 | 2573 | 31546480 |
| Product quality issue | 12.05 | 10.20 | 37 | 148254 | 16074 | 31532979 |
| Ankylosing spondylitis | 12.03 | 10.20 | 57 | 148234 | 5824 | 31543229 |
| Drug level increased | 12.02 | 10.20 | 51 | 148240 | 20135 | 31528918 |
| Neonatal seizure | 11.98 | 10.20 | 13 | 148278 | 471 | 31548582 |
| Pulmonary artery stenosis congenital | 11.94 | 10.20 | 13 | 148278 | 473 | 31548580 |
| Respiratory tract infection viral | 11.92 | 10.20 | 28 | 148263 | 1986 | 31547067 |
| Hepatocellular injury | 11.89 | 10.20 | 56 | 148235 | 21488 | 31527565 |
| Tooth injury | 11.85 | 10.20 | 20 | 148271 | 1114 | 31547939 |
| Chronic graft versus host disease | 11.78 | 10.20 | 3 | 148288 | 4389 | 31544664 |
| Neonatal infection | 11.75 | 10.20 | 12 | 148279 | 405 | 31548648 |
| Cystitis haemorrhagic | 11.75 | 10.20 | 5 | 148286 | 5284 | 31543769 |
| Akathisia | 11.72 | 10.20 | 10 | 148281 | 7243 | 31541810 |
| Meningeal disorder | 11.70 | 10.20 | 11 | 148280 | 335 | 31548718 |
| Cholestasis | 11.70 | 10.20 | 69 | 148222 | 25006 | 31524047 |
| Fine motor skill dysfunction | 11.69 | 10.20 | 25 | 148266 | 1665 | 31547388 |
| Diverticular perforation | 11.67 | 10.20 | 37 | 148254 | 3132 | 31545921 |
| Vomiting | 11.65 | 10.20 | 896 | 147395 | 223077 | 31325976 |
| Nephrolithiasis | 11.57 | 10.20 | 186 | 148105 | 27153 | 31521900 |
| Acute chest syndrome | 11.46 | 10.20 | 11 | 148280 | 344 | 31548709 |
| Metabolic acidosis | 11.45 | 10.20 | 124 | 148167 | 39453 | 31509600 |
| Excessive cerumen production | 11.45 | 10.20 | 10 | 148281 | 276 | 31548777 |
| Kidney infection | 11.42 | 10.20 | 49 | 148242 | 4801 | 31544252 |
| Pharyngitis | 11.39 | 10.20 | 66 | 148225 | 7292 | 31541761 |
| Adenovirus infection | 11.38 | 10.20 | 4 | 148287 | 4750 | 31544303 |
| Injection site bruising | 11.36 | 10.20 | 70 | 148221 | 7905 | 31541148 |
| Myopia | 11.31 | 10.20 | 19 | 148272 | 1054 | 31547999 |
| Scrotal infection | 11.31 | 10.20 | 14 | 148277 | 586 | 31548467 |
| Gross motor delay | 11.30 | 10.20 | 10 | 148281 | 281 | 31548772 |
| Myoclonus | 11.29 | 10.20 | 31 | 148260 | 13959 | 31535094 |
| Progressive multifocal leukoencephalopathy | 11.25 | 10.20 | 16 | 148275 | 9197 | 31539856 |
| Major depression | 11.22 | 10.20 | 3 | 148288 | 4250 | 31544803 |
| Psychomotor skills impaired | 11.05 | 10.20 | 36 | 148255 | 3091 | 31545962 |
| Dermatitis psoriasiform | 11.02 | 10.20 | 20 | 148271 | 1180 | 31547873 |
| End stage renal disease | 11.02 | 10.20 | 13 | 148278 | 8096 | 31540957 |
| Folate deficiency | 11 | 10.20 | 20 | 148271 | 1182 | 31547871 |
| Withdrawal syndrome | 11.00 | 10.20 | 24 | 148267 | 11693 | 31537360 |
| Second primary malignancy | 10.99 | 10.20 | 10 | 148281 | 7022 | 31542031 |
| Mobility decreased | 10.93 | 10.20 | 185 | 148106 | 27284 | 31521769 |
| Neck pain | 10.90 | 10.20 | 159 | 148132 | 22751 | 31526302 |
| Pyelocaliectasis | 10.83 | 10.20 | 19 | 148272 | 1092 | 31547961 |
| Anal fissure | 10.81 | 10.20 | 38 | 148253 | 3391 | 31545662 |
| Cleft palate | 10.80 | 10.20 | 14 | 148277 | 614 | 31548439 |
| Cerebral ventricle dilatation | 10.77 | 10.20 | 17 | 148274 | 895 | 31548158 |
| Lung neoplasm | 10.75 | 10.20 | 45 | 148246 | 4361 | 31544692 |
| Latent tuberculosis | 10.74 | 10.20 | 20 | 148271 | 1204 | 31547849 |
| Foetal hypokinesia | 10.73 | 10.20 | 11 | 148280 | 373 | 31548680 |
| Pneumonia | 10.65 | 10.20 | 1754 | 146537 | 333558 | 31215495 |
| Suspected suicide | 10.64 | 10.20 | 3 | 148288 | 4104 | 31544949 |
| Erectile dysfunction | 10.61 | 10.20 | 50 | 148241 | 19185 | 31529868 |
| Ulna fracture | 10.61 | 10.20 | 11 | 148280 | 378 | 31548675 |
| Pancreatic duct stenosis | 10.58 | 10.20 | 8 | 148283 | 179 | 31548874 |
| Non-Hodgkin's lymphoma | 10.55 | 10.20 | 23 | 148268 | 1552 | 31547501 |
| Acute graft versus host disease | 10.54 | 10.20 | 8 | 148283 | 6145 | 31542908 |
| Hepatic encephalopathy | 10.51 | 10.20 | 31 | 148260 | 13640 | 31535413 |
| Obsessive-compulsive disorder | 10.45 | 10.20 | 5 | 148286 | 4932 | 31544121 |
| Oesophageal atresia | 10.40 | 10.20 | 12 | 148279 | 466 | 31548587 |
| Weight increased | 10.37 | 10.20 | 481 | 147810 | 82466 | 31466587 |
| Haematochezia | 10.29 | 10.20 | 255 | 148036 | 40209 | 31508844 |
| Nail pitting | 10.26 | 10.20 | 9 | 148282 | 250 | 31548803 |
| Nose deformity | 10.21 | 10.20 | 8 | 148283 | 189 | 31548864 |
| Pleuritic pain | 10.21 | 10.20 | 35 | 148256 | 3085 | 31545968 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Rheumatoid arthritis | 1785.89 | 9.94 | 4908 | 438308 | 286897 | 70198331 |
| Arthropathy | 998.60 | 9.94 | 2606 | 440610 | 147451 | 70337777 |
| Joint swelling | 980.49 | 9.94 | 3641 | 439575 | 249570 | 70235658 |
| Pemphigus | 972.21 | 9.94 | 1810 | 441406 | 81226 | 70404002 |
| Completed suicide | 956.89 | 9.94 | 140 | 443076 | 226995 | 70258233 |
| Systemic lupus erythematosus | 940.53 | 9.94 | 2011 | 441205 | 99891 | 70385337 |
| Hand deformity | 937.10 | 9.94 | 1824 | 441392 | 84658 | 70400570 |
| Synovitis | 918.50 | 9.94 | 2301 | 440915 | 126927 | 70358301 |
| Glossodynia | 847.15 | 9.94 | 1749 | 441467 | 84738 | 70400490 |
| Toxicity to various agents | 828.63 | 9.94 | 703 | 442513 | 381469 | 70103759 |
| Arthralgia | 784.68 | 9.94 | 5604 | 437612 | 497786 | 69987442 |
| Infusion related reaction | 729.72 | 9.94 | 2799 | 440417 | 194735 | 70290493 |
| Anti-cyclic citrullinated peptide antibody positive | 722.44 | 9.94 | 1449 | 441767 | 68736 | 70416492 |
| Maternal exposure during pregnancy | 702.31 | 9.94 | 1939 | 441277 | 113406 | 70371822 |
| Wound | 700.24 | 9.94 | 1757 | 441459 | 96975 | 70388253 |
| Pericarditis | 690.56 | 9.94 | 1591 | 441625 | 83114 | 70402114 |
| Drug abuse | 681.09 | 9.94 | 66 | 443150 | 147190 | 70338038 |
| Abdominal discomfort | 571.50 | 9.94 | 2755 | 440461 | 211903 | 70273325 |
| Pain | 556.92 | 9.94 | 6187 | 437029 | 622629 | 69862599 |
| Therapeutic product effect decreased | 538.89 | 9.94 | 2040 | 441176 | 140978 | 70344250 |
| Alopecia | 534.46 | 9.94 | 2556 | 440660 | 195934 | 70289294 |
| Discomfort | 531.18 | 9.94 | 1657 | 441559 | 103779 | 70381449 |
| Swelling | 522.28 | 9.94 | 2448 | 440768 | 186091 | 70299137 |
| Contraindicated product administered | 502.09 | 9.94 | 1914 | 441302 | 132698 | 70352530 |
| Drug intolerance | 450.18 | 9.94 | 2676 | 440540 | 223011 | 70262217 |
| Duodenal ulcer perforation | 445.36 | 9.94 | 986 | 442230 | 50126 | 70435102 |
| Helicobacter infection | 442.07 | 9.94 | 1035 | 442181 | 54621 | 70430607 |
| Nasopharyngitis | 437.61 | 9.94 | 2626 | 440590 | 219580 | 70265648 |
| Drug interaction | 427.09 | 9.94 | 1110 | 442106 | 380331 | 70104897 |
| Musculoskeletal stiffness | 421.90 | 9.94 | 1936 | 441280 | 145824 | 70339404 |
| Death | 420 | 9.94 | 1702 | 441514 | 508359 | 69976869 |
| Rheumatoid factor positive | 419.81 | 9.94 | 932 | 442284 | 47468 | 70437760 |
| Hepatic enzyme increased | 411.85 | 9.94 | 2007 | 441209 | 154983 | 70330245 |
| Intentional overdose | 358.25 | 9.94 | 87 | 443129 | 98348 | 70386880 |
| Exposure during pregnancy | 339.98 | 9.94 | 1263 | 441953 | 86454 | 70398774 |
| Acute kidney injury | 326.04 | 9.94 | 1692 | 441524 | 472932 | 70012296 |
| Impaired healing | 297.55 | 9.94 | 1082 | 442134 | 73292 | 70411936 |
| C-reactive protein abnormal | 296.08 | 9.94 | 708 | 442508 | 37871 | 70447357 |
| Treatment failure | 283.83 | 9.94 | 1704 | 441512 | 142438 | 70342790 |
| Psoriatic arthropathy | 281.18 | 9.94 | 968 | 442248 | 63803 | 70421425 |
| Hypersensitivity | 267.62 | 9.94 | 2396 | 440820 | 227416 | 70257812 |
| Febrile neutropenia | 264.16 | 9.94 | 550 | 442666 | 203768 | 70281460 |
| Sinusitis | 262.45 | 9.94 | 1884 | 441332 | 167311 | 70317917 |
| Lower respiratory tract infection | 261.97 | 9.94 | 1386 | 441830 | 110527 | 70374701 |
| Muscle injury | 256.07 | 9.94 | 669 | 442547 | 37825 | 70447403 |
| Peripheral swelling | 255.58 | 9.94 | 2427 | 440789 | 234136 | 70251092 |
| Folliculitis | 242.54 | 9.94 | 699 | 442517 | 41871 | 70443357 |
| Product use issue | 242.22 | 9.94 | 1938 | 441278 | 177999 | 70307229 |
| Irritable bowel syndrome | 236.66 | 9.94 | 778 | 442438 | 50072 | 70435156 |
| Overdose | 227.86 | 9.94 | 447 | 442769 | 169298 | 70315930 |
| Cardiac arrest | 225.90 | 9.94 | 408 | 442808 | 159426 | 70325802 |
| Sleep disorder due to general medical condition, insomnia type | 222.51 | 9.94 | 606 | 442610 | 35126 | 70450102 |
| Red blood cell sedimentation rate abnormal | 219.74 | 9.94 | 416 | 442800 | 18887 | 70466341 |
| Blister | 217.07 | 9.94 | 1218 | 441998 | 99308 | 70385920 |
| Suicide attempt | 216.67 | 9.94 | 113 | 443103 | 79397 | 70405831 |
| Depressed level of consciousness | 206.54 | 9.94 | 147 | 443069 | 87284 | 70397944 |
| Arthritis | 201.61 | 9.94 | 1172 | 442044 | 96808 | 70388420 |
| Blood pressure fluctuation | 192.44 | 9.94 | 805 | 442411 | 58207 | 70427021 |
| Bradycardia | 191.85 | 9.94 | 301 | 442915 | 124314 | 70360914 |
| Knee arthroplasty | 189.41 | 9.94 | 557 | 442659 | 33744 | 70451484 |
| Weight increased | 183.51 | 9.94 | 2317 | 440899 | 240014 | 70245214 |
| Sickle cell anaemia with crisis | 181.41 | 9.94 | 205 | 443011 | 5773 | 70479455 |
| Hip arthroplasty | 180.06 | 9.94 | 481 | 442735 | 27559 | 70457669 |
| Infection | 169.32 | 9.94 | 2038 | 441178 | 208747 | 70276481 |
| Osteoarthritis | 167.81 | 9.94 | 910 | 442306 | 73237 | 70411991 |
| Drug ineffective | 164.87 | 9.94 | 7307 | 435909 | 932445 | 69552783 |
| Rhabdomyolysis | 162.45 | 9.94 | 216 | 443000 | 95544 | 70389684 |
| Pregnancy | 161.95 | 9.94 | 417 | 442799 | 23364 | 70461864 |
| Renal failure | 158.84 | 9.94 | 625 | 442591 | 188445 | 70296783 |
| Cardiac failure | 157.78 | 9.94 | 421 | 442795 | 143120 | 70342108 |
| Lactic acidosis | 155.32 | 9.94 | 108 | 443108 | 64916 | 70420312 |
| Disease progression | 155.04 | 9.94 | 483 | 442733 | 156189 | 70329039 |
| Respiratory arrest | 152.43 | 9.94 | 73 | 443143 | 53860 | 70431368 |
| Ill-defined disorder | 142.75 | 9.94 | 699 | 442517 | 54042 | 70431186 |
| Rheumatic fever | 141.89 | 9.94 | 330 | 442886 | 17330 | 70467898 |
| Drug reaction with eosinophilia and systemic symptoms | 141.71 | 9.94 | 94 | 443122 | 57919 | 70427309 |
| Malignant neoplasm progression | 140.75 | 9.94 | 348 | 442868 | 121391 | 70363837 |
| Sedation | 140.33 | 9.94 | 58 | 443158 | 46673 | 70438555 |
| Neutropenia | 135.41 | 9.94 | 995 | 442221 | 256161 | 70229067 |
| Sopor | 134.49 | 9.94 | 18 | 443198 | 31249 | 70453979 |
| Red blood cell sedimentation rate increased | 132.97 | 9.94 | 536 | 442680 | 38106 | 70447122 |
| Blood pressure systolic increased | 131.09 | 9.94 | 705 | 442511 | 56554 | 70428674 |
| Serotonin syndrome | 130.18 | 9.94 | 50 | 443166 | 42064 | 70443164 |
| Condition aggravated | 130.01 | 9.94 | 3545 | 439671 | 424090 | 70061138 |
| Abortion spontaneous | 128.48 | 9.94 | 411 | 442805 | 26068 | 70459160 |
| Constipation | 128.04 | 9.94 | 987 | 442229 | 251451 | 70233777 |
| Contusion | 125.14 | 9.94 | 1287 | 441929 | 126749 | 70358479 |
| Hypotension | 121.40 | 9.94 | 1787 | 441429 | 402594 | 70082634 |
| Hepatic function abnormal | 120.89 | 9.94 | 148 | 443068 | 67848 | 70417380 |
| Blood pressure diastolic abnormal | 117.29 | 9.94 | 283 | 442933 | 15221 | 70470007 |
| Drug resistance | 116.95 | 9.94 | 46 | 443170 | 38144 | 70447084 |
| Agitation | 116.70 | 9.94 | 256 | 442960 | 93119 | 70392109 |
| Rash | 116.03 | 9.94 | 4085 | 439131 | 506477 | 69978751 |
| Swollen joint count increased | 115.59 | 9.94 | 261 | 442955 | 13439 | 70471789 |
| Fibromyalgia | 113.38 | 9.94 | 595 | 442621 | 47279 | 70437949 |
| Hypoglycaemia | 112.83 | 9.94 | 265 | 442951 | 94099 | 70391129 |
| Drug dependence | 109.37 | 9.94 | 48 | 443168 | 37273 | 70447955 |
| Respiratory failure | 108.60 | 9.94 | 614 | 442602 | 168121 | 70317107 |
| Cytomegalovirus infection | 106.10 | 9.94 | 58 | 443158 | 39700 | 70445528 |
| Joint effusion | 106.01 | 9.94 | 272 | 442944 | 15205 | 70470023 |
| Coma | 105.80 | 9.94 | 263 | 442953 | 91581 | 70393647 |
| Enthesopathy | 105.34 | 9.94 | 219 | 442997 | 10650 | 70474578 |
| Osteoporosis | 105.13 | 9.94 | 592 | 442624 | 48315 | 70436913 |
| Renal impairment | 104.86 | 9.94 | 502 | 442714 | 143435 | 70341793 |
| Somnolence | 104.66 | 9.94 | 853 | 442363 | 214753 | 70270475 |
| Blood pressure systolic abnormal | 104.56 | 9.94 | 242 | 442974 | 12667 | 70472561 |
| C-reactive protein increased | 102.85 | 9.94 | 1100 | 442116 | 109417 | 70375811 |
| Injection site erythema | 102.15 | 9.94 | 793 | 442423 | 72131 | 70413097 |
| Hyponatraemia | 101.70 | 9.94 | 585 | 442631 | 159502 | 70325726 |
| Product use in unapproved indication | 101.55 | 9.94 | 819 | 442397 | 206659 | 70278569 |
| Fatigue | 101.48 | 9.94 | 6200 | 437016 | 818119 | 69667109 |
| Multiple organ dysfunction syndrome | 100.76 | 9.94 | 344 | 442872 | 108171 | 70377057 |
| Inflammation | 100.71 | 9.94 | 838 | 442378 | 77827 | 70407401 |
| Grip strength decreased | 100.63 | 9.94 | 269 | 442947 | 15416 | 70469812 |
| Joint stiffness | 100.31 | 9.94 | 461 | 442755 | 34715 | 70450513 |
| Foot deformity | 99.66 | 9.94 | 320 | 442896 | 20335 | 70464893 |
| Musculoskeletal pain | 99.49 | 9.94 | 931 | 442285 | 89396 | 70395832 |
| Electrocardiogram QT prolonged | 99.48 | 9.94 | 235 | 442981 | 83282 | 70401946 |
| Hepatic failure | 98.72 | 9.94 | 129 | 443087 | 57496 | 70427732 |
| Cardio-respiratory arrest | 98.42 | 9.94 | 312 | 442904 | 100365 | 70384863 |
| Intentional self-injury | 97.12 | 9.94 | 38 | 443178 | 31612 | 70453616 |
| Plasma cell myeloma | 95.39 | 9.94 | 196 | 443020 | 73005 | 70412223 |
| Hyperglycaemia | 95.02 | 9.94 | 161 | 443055 | 64511 | 70420717 |
| Stomatitis | 94.28 | 9.94 | 1222 | 441994 | 127289 | 70357939 |
| Rheumatoid nodule | 94.25 | 9.94 | 256 | 442960 | 14811 | 70470417 |
| Pain in extremity | 94.06 | 9.94 | 2700 | 440516 | 325382 | 70159846 |
| Blood pressure diastolic decreased | 93.05 | 9.94 | 363 | 442853 | 25417 | 70459811 |
| Gastrointestinal disorder | 92.42 | 9.94 | 1037 | 442179 | 104390 | 70380838 |
| Live birth | 89.10 | 9.94 | 237 | 442979 | 13542 | 70471686 |
| Tenosynovitis | 85.97 | 9.94 | 236 | 442980 | 13740 | 70471488 |
| Injection site pruritus | 85.85 | 9.94 | 477 | 442739 | 38733 | 70446495 |
| Neoplasm progression | 85.18 | 9.94 | 94 | 443122 | 45134 | 70440094 |
| Disability assessment scale score increased | 83.61 | 9.94 | 98 | 443118 | 2873 | 70482355 |
| Bone erosion | 83.38 | 9.94 | 246 | 442970 | 14927 | 70470301 |
| Hypoxia | 81.93 | 9.94 | 303 | 442913 | 93041 | 70392187 |
| Intentional product misuse | 81.83 | 9.94 | 241 | 442975 | 79354 | 70405874 |
| Palmar-plantar erythrodysaesthesia syndrome | 80.90 | 9.94 | 44 | 443172 | 30203 | 70455025 |
| Heart rate decreased | 80.64 | 9.94 | 663 | 442553 | 61352 | 70423876 |
| Poisoning | 80.33 | 9.94 | 21 | 443195 | 22601 | 70462627 |
| Device expulsion | 80.25 | 9.94 | 20 | 443196 | 22226 | 70463002 |
| Cardiac failure congestive | 79.21 | 9.94 | 508 | 442708 | 134949 | 70350279 |
| Altered state of consciousness | 78.94 | 9.94 | 80 | 443136 | 39942 | 70445286 |
| Tachycardia | 77.95 | 9.94 | 625 | 442591 | 157921 | 70327307 |
| Syncope | 77.94 | 9.94 | 661 | 442555 | 165048 | 70320180 |
| Injection site reaction | 77.69 | 9.94 | 556 | 442660 | 49296 | 70435932 |
| Shock | 77.26 | 9.94 | 83 | 443133 | 40342 | 70444886 |
| Drug withdrawal syndrome | 77.25 | 9.94 | 55 | 443161 | 32660 | 70452568 |
| Metabolic acidosis | 77.24 | 9.94 | 224 | 442992 | 74122 | 70411106 |
| Hyperhidrosis | 73.65 | 9.94 | 500 | 442716 | 131086 | 70354142 |
| Neuropathy peripheral | 73.63 | 9.94 | 477 | 442739 | 126419 | 70358809 |
| Angioedema | 71.92 | 9.94 | 197 | 443019 | 66413 | 70418815 |
| Localised infection | 71.68 | 9.94 | 402 | 442814 | 32756 | 70452472 |
| Thrombocytopenia | 71.51 | 9.94 | 1057 | 442159 | 238053 | 70247175 |
| Loss of personal independence in daily activities | 71.17 | 9.94 | 828 | 442388 | 84082 | 70401146 |
| Injection site pain | 71.17 | 9.94 | 1081 | 442135 | 116538 | 70368690 |
| Disseminated intravascular coagulation | 69.94 | 9.94 | 64 | 443152 | 33534 | 70451694 |
| Blood cholesterol increased | 69.20 | 9.94 | 662 | 442554 | 63942 | 70421286 |
| Tremor | 69.10 | 9.94 | 630 | 442586 | 154994 | 70330234 |
| Pulmonary arterial hypertension | 69.09 | 9.94 | 62 | 443154 | 32793 | 70452435 |
| Cholestasis | 68.66 | 9.94 | 121 | 443095 | 47751 | 70437477 |
| Caesarean section | 68.43 | 9.94 | 193 | 443023 | 11414 | 70473814 |
| Respiratory depression | 68.06 | 9.94 | 35 | 443181 | 24796 | 70460432 |
| Blood creatine phosphokinase increased | 67.79 | 9.94 | 179 | 443037 | 61084 | 70424144 |
| Seizure | 67.57 | 9.94 | 748 | 442468 | 177214 | 70308014 |
| Joint laxity | 67.24 | 9.94 | 78 | 443138 | 2261 | 70482967 |
| Psoriasis | 66.40 | 9.94 | 922 | 442294 | 97511 | 70387717 |
| Acute hepatic failure | 66.02 | 9.94 | 46 | 443170 | 27626 | 70457602 |
| Cognitive disorder | 66.02 | 9.94 | 180 | 443036 | 60776 | 70424452 |
| Mydriasis | 65.56 | 9.94 | 11 | 443205 | 16142 | 70469086 |
| Immune reconstitution inflammatory syndrome | 65.14 | 9.94 | 4 | 443212 | 12986 | 70472242 |
| Joint range of motion decreased | 64.76 | 9.94 | 328 | 442888 | 25698 | 70459530 |
| Polyarthritis | 64.55 | 9.94 | 180 | 443036 | 10576 | 70474652 |
| Vomiting | 64.13 | 9.94 | 3041 | 440175 | 590070 | 69895158 |
| Blood pressure increased | 63.86 | 9.94 | 1586 | 441630 | 186931 | 70298297 |
| Injection site swelling | 63.05 | 9.94 | 474 | 442742 | 42683 | 70442545 |
| Cerebral haemorrhage | 63.00 | 9.94 | 153 | 443063 | 53711 | 70431517 |
| Hepatocellular injury | 62.98 | 9.94 | 120 | 443096 | 45971 | 70439257 |
| Encephalopathy | 62.44 | 9.94 | 188 | 443028 | 61473 | 70423755 |
| Basal cell carcinoma | 62.21 | 9.94 | 392 | 442824 | 33306 | 70451922 |
| Pulmonary fibrosis | 62.03 | 9.94 | 397 | 442819 | 33913 | 70451315 |
| Sedation complication | 61.98 | 9.94 | 6 | 443210 | 13404 | 70471824 |
| Delirium | 61.74 | 9.94 | 248 | 442968 | 74366 | 70410862 |
| Anxiety | 61.45 | 9.94 | 987 | 442229 | 219343 | 70265885 |
| Intentional product use issue | 61.44 | 9.94 | 1074 | 442142 | 119068 | 70366160 |
| Myocardial infarction | 61.44 | 9.94 | 731 | 442485 | 170914 | 70314314 |
| Juvenile idiopathic arthritis | 61.12 | 9.94 | 121 | 443095 | 5679 | 70479549 |
| Gestational diabetes | 60.62 | 9.94 | 123 | 443093 | 5878 | 70479350 |
| Asthma | 60.37 | 9.94 | 474 | 442742 | 120319 | 70364909 |
| Joint destruction | 59.79 | 9.94 | 106 | 443110 | 4572 | 70480656 |
| Tendonitis | 59.47 | 9.94 | 285 | 442931 | 21837 | 70463391 |
| Tongue disorder | 59.40 | 9.94 | 200 | 443016 | 13027 | 70472201 |
| Hallucination | 59.06 | 9.94 | 260 | 442956 | 76000 | 70409228 |
| Dehydration | 57.87 | 9.94 | 1029 | 442187 | 225113 | 70260115 |
| Myalgia | 57.44 | 9.94 | 722 | 442494 | 167170 | 70318058 |
| Neuroleptic malignant syndrome | 57.22 | 9.94 | 47 | 443169 | 25960 | 70459268 |
| Hyperkalaemia | 57.19 | 9.94 | 410 | 442806 | 106181 | 70379047 |
| Blood pressure diastolic increased | 57.11 | 9.94 | 189 | 443027 | 12202 | 70473026 |
| Disability | 56.55 | 9.94 | 214 | 443002 | 14769 | 70470459 |
| Body temperature decreased | 56.37 | 9.94 | 339 | 442877 | 28333 | 70456895 |
| Joint injury | 55.90 | 9.94 | 323 | 442893 | 26609 | 70458619 |
| Disturbance in attention | 55.75 | 9.94 | 115 | 443101 | 42779 | 70442449 |
| Femur fracture | 55.15 | 9.94 | 401 | 442815 | 35731 | 70449497 |
| Ventricular tachycardia | 55.05 | 9.94 | 89 | 443127 | 36334 | 70448894 |
| Asthenia | 54.20 | 9.94 | 2323 | 440893 | 455343 | 70029885 |
| Abnormal behaviour | 54.18 | 9.94 | 83 | 443133 | 34626 | 70450602 |
| Red blood cell sedimentation rate | 53.64 | 9.94 | 104 | 443112 | 4806 | 70480422 |
| Nodule | 53.49 | 9.94 | 257 | 442959 | 19712 | 70465516 |
| Injection site bruising | 53.48 | 9.94 | 414 | 442802 | 37618 | 70447610 |
| Dyspnoea | 53.02 | 9.94 | 4119 | 439097 | 765941 | 69719287 |
| Diabetic ketoacidosis | 52.49 | 9.94 | 72 | 443144 | 31440 | 70453788 |
| Restlessness | 52.21 | 9.94 | 116 | 443100 | 42012 | 70443216 |
| Diarrhoea | 51.78 | 9.94 | 4204 | 439012 | 779137 | 69706091 |
| Orthostatic hypotension | 51.51 | 9.94 | 159 | 443057 | 51584 | 70433644 |
| Laryngitis | 50.88 | 9.94 | 194 | 443022 | 13437 | 70471791 |
| Mental status changes | 50.79 | 9.94 | 212 | 443004 | 62889 | 70422339 |
| Post transplant lymphoproliferative disorder | 50.69 | 9.94 | 4 | 443212 | 10541 | 70474687 |
| Leukopenia | 50.56 | 9.94 | 424 | 442792 | 106136 | 70379092 |
| Alanine aminotransferase abnormal | 50.48 | 9.94 | 137 | 443079 | 7922 | 70477306 |
| Anaemia | 50.00 | 9.94 | 2037 | 441179 | 401386 | 70083842 |
| Infective pulmonary exacerbation of cystic fibrosis | 49.97 | 9.94 | 8 | 443208 | 12150 | 70473078 |
| Nausea | 49.95 | 9.94 | 4616 | 438600 | 847472 | 69637756 |
| Disorientation | 49.53 | 9.94 | 190 | 443026 | 57733 | 70427495 |
| Myoclonus | 49.38 | 9.94 | 55 | 443161 | 26300 | 70458928 |
| Unresponsive to stimuli | 49.30 | 9.94 | 163 | 443053 | 51768 | 70433460 |
| Mobility decreased | 48.87 | 9.94 | 910 | 442306 | 102089 | 70383139 |
| Drug ineffective for unapproved indication | 48.68 | 9.94 | 105 | 443111 | 38433 | 70446795 |
| Psychotic disorder | 48.22 | 9.94 | 102 | 443114 | 37599 | 70447629 |
| Suicidal ideation | 48.20 | 9.94 | 247 | 442969 | 69349 | 70415879 |
| Multiple sclerosis relapse | 48.12 | 9.94 | 125 | 443091 | 42892 | 70442336 |
| Atrial fibrillation | 48.06 | 9.94 | 836 | 442380 | 183512 | 70301716 |
| Neutrophil count decreased | 47.99 | 9.94 | 315 | 442901 | 83241 | 70401987 |
| Speech disorder | 47.85 | 9.94 | 159 | 443057 | 50421 | 70434807 |
| Oropharyngeal pain | 47.83 | 9.94 | 857 | 442359 | 95453 | 70389775 |
| Tenderness | 47.75 | 9.94 | 260 | 442956 | 20950 | 70464278 |
| Cytokine release syndrome | 47.68 | 9.94 | 57 | 443159 | 26410 | 70458818 |
| Drug level increased | 47.21 | 9.94 | 98 | 443118 | 36371 | 70448857 |
| Hypothermia | 46.84 | 9.94 | 36 | 443180 | 20558 | 70464670 |
| Synovial cyst | 46.39 | 9.94 | 140 | 443076 | 8602 | 70476626 |
| Blood glucose increased | 46.09 | 9.94 | 416 | 442800 | 102566 | 70382662 |
| Skin ulcer | 46.07 | 9.94 | 482 | 442734 | 47663 | 70437565 |
| Hypokalaemia | 46.06 | 9.94 | 561 | 442655 | 130627 | 70354601 |
| Irritability | 45.95 | 9.94 | 107 | 443109 | 38118 | 70447110 |
| Neurotoxicity | 45.91 | 9.94 | 72 | 443144 | 29754 | 70455474 |
| Extrapyramidal disorder | 45.03 | 9.94 | 38 | 443178 | 20712 | 70464516 |
| Anaphylactic shock | 44.91 | 9.94 | 84 | 443132 | 32406 | 70452822 |
| Ejection fraction decreased | 44.80 | 9.94 | 77 | 443139 | 30685 | 70454543 |
| Neck deformity | 44.51 | 9.94 | 55 | 443161 | 1706 | 70483522 |
| Adverse event | 44.46 | 9.94 | 489 | 442727 | 48972 | 70436256 |
| Balance disorder | 44.41 | 9.94 | 355 | 442861 | 89773 | 70395455 |
| Maternal exposure before pregnancy | 44.37 | 9.94 | 83 | 443133 | 3733 | 70481495 |
| Melaena | 44.33 | 9.94 | 191 | 443025 | 56164 | 70429064 |
| Venoocclusive liver disease | 43.95 | 9.94 | 7 | 443209 | 10671 | 70474557 |
| Substance abuse | 43.93 | 9.94 | 5 | 443211 | 9832 | 70475396 |
| Pulmonary embolism | 43.51 | 9.94 | 698 | 442518 | 155169 | 70330059 |
| Multiple fractures | 43.37 | 9.94 | 116 | 443100 | 6649 | 70478579 |
| Respiratory distress | 43.12 | 9.94 | 185 | 443031 | 54465 | 70430763 |
| Aggression | 42.67 | 9.94 | 157 | 443059 | 48289 | 70436939 |
| Arrhythmia | 42.52 | 9.94 | 193 | 443023 | 55950 | 70429278 |
| Pre-eclampsia | 42.39 | 9.94 | 112 | 443104 | 6373 | 70478855 |
| Aspergillus infection | 42.24 | 9.94 | 30 | 443186 | 17838 | 70467390 |
| Dizziness | 42.07 | 9.94 | 2422 | 440794 | 461719 | 70023509 |
| Torsade de pointes | 42.06 | 9.94 | 31 | 443185 | 18085 | 70467143 |
| No adverse event | 41.96 | 9.94 | 86 | 443130 | 32067 | 70453161 |
| Psychomotor hyperactivity | 41.93 | 9.94 | 22 | 443194 | 15411 | 70469817 |
| Fracture | 41.92 | 9.94 | 240 | 442976 | 19704 | 70465524 |
| Herpes zoster | 41.81 | 9.94 | 757 | 442459 | 84478 | 70400750 |
| Product quality issue | 41.38 | 9.94 | 80 | 443136 | 30481 | 70454747 |
| Blood creatinine increased | 41.05 | 9.94 | 637 | 442579 | 142364 | 70342864 |
| Inappropriate antidiuretic hormone secretion | 41.01 | 9.94 | 51 | 443165 | 23225 | 70462003 |
| Injection site rash | 40.96 | 9.94 | 207 | 443009 | 16203 | 70469025 |
| Ear infection | 40.70 | 9.94 | 310 | 442906 | 28026 | 70457202 |
| Pathogen resistance | 40.65 | 9.94 | 16 | 443200 | 13263 | 70471965 |
| Brain oedema | 40.54 | 9.94 | 52 | 443164 | 23366 | 70461862 |
| Therapeutic response decreased | 40.42 | 9.94 | 550 | 442666 | 57903 | 70427325 |
| Latent tuberculosis | 40.25 | 9.94 | 71 | 443145 | 3050 | 70482178 |
| Type 2 diabetes mellitus | 40.17 | 9.94 | 437 | 442779 | 43643 | 70441585 |
| Depression | 39.99 | 9.94 | 942 | 442274 | 198032 | 70287196 |
| Asphyxia | 39.92 | 9.94 | 8 | 443208 | 10334 | 70474894 |
| Vision blurred | 39.80 | 9.94 | 390 | 442826 | 94594 | 70390634 |
| Proteinuria | 39.68 | 9.94 | 77 | 443139 | 29297 | 70455931 |
| Poor venous access | 39.61 | 9.94 | 192 | 443024 | 14779 | 70470449 |
| Premature labour | 39.56 | 9.94 | 125 | 443091 | 7875 | 70477353 |
| Premature rupture of membranes | 39.50 | 9.94 | 80 | 443136 | 3818 | 70481410 |
| Gastrointestinal haemorrhage | 39.47 | 9.94 | 612 | 442604 | 136796 | 70348432 |
| Premature delivery | 39.43 | 9.94 | 248 | 442968 | 21056 | 70464172 |
| Posterior reversible encephalopathy syndrome | 39.41 | 9.94 | 57 | 443159 | 24345 | 70460883 |
| Fluid retention | 38.96 | 9.94 | 234 | 442982 | 63151 | 70422077 |
| Joint dislocation | 38.91 | 9.94 | 187 | 443029 | 14344 | 70470884 |
| Limb deformity | 38.60 | 9.94 | 74 | 443142 | 3391 | 70481837 |
| Withdrawal syndrome | 38.45 | 9.94 | 60 | 443156 | 24844 | 70460384 |
| Loss of consciousness | 38.10 | 9.94 | 714 | 442502 | 155002 | 70330226 |
| Bronchopulmonary aspergillosis | 38.08 | 9.94 | 45 | 443171 | 20957 | 70464271 |
| Second primary malignancy | 37.90 | 9.94 | 17 | 443199 | 13034 | 70472194 |
| Cerebrovascular accident | 37.58 | 9.94 | 650 | 442566 | 142820 | 70342408 |
| Blood parathyroid hormone decreased | 37.52 | 9.94 | 133 | 443083 | 8891 | 70476337 |
| Fear of injection | 37.45 | 9.94 | 109 | 443107 | 6563 | 70478665 |
| Maternal exposure timing unspecified | 37.43 | 9.94 | 84 | 443132 | 4307 | 70480921 |
| Akathisia | 37.32 | 9.94 | 15 | 443201 | 12278 | 70472950 |
| Coronary artery disease | 37.31 | 9.94 | 234 | 442982 | 62502 | 70422726 |
| Cardiogenic shock | 37.26 | 9.94 | 110 | 443106 | 36197 | 70449031 |
| Agranulocytosis | 37.22 | 9.94 | 128 | 443088 | 40170 | 70445058 |
| Cerebral infarction | 36.82 | 9.94 | 141 | 443075 | 42868 | 70442360 |
| Drug use disorder | 36.76 | 9.94 | 4 | 443212 | 8147 | 70477081 |
| Creatinine renal clearance decreased | 36.72 | 9.94 | 32 | 443184 | 17168 | 70468060 |
| Decreased appetite | 36.44 | 9.94 | 1545 | 441671 | 303235 | 70181993 |
| Transplant rejection | 36.20 | 9.94 | 36 | 443180 | 18135 | 70467093 |
| Gamma-glutamyltransferase increased | 36.17 | 9.94 | 178 | 443038 | 50507 | 70434721 |
| Granuloma skin | 36.14 | 9.94 | 118 | 443098 | 7564 | 70477664 |
| Pulmonary oedema | 36.10 | 9.94 | 334 | 442882 | 81944 | 70403284 |
| Bursitis | 35.66 | 9.94 | 287 | 442929 | 26386 | 70458842 |
| Ascites | 35.66 | 9.94 | 261 | 442955 | 67286 | 70417942 |
| Miosis | 35.59 | 9.94 | 22 | 443194 | 14079 | 70471149 |
| Neck mass | 35.59 | 9.94 | 80 | 443136 | 4106 | 70481122 |
| Smear cervix abnormal | 35.52 | 9.94 | 58 | 443158 | 2338 | 70482890 |
| Coagulopathy | 35.39 | 9.94 | 99 | 443117 | 33150 | 70452078 |
| Rash maculo-papular | 35.22 | 9.94 | 179 | 443037 | 50366 | 70434862 |
| Lupus-like syndrome | 35.14 | 9.94 | 154 | 443062 | 11361 | 70473867 |
| Arthritis infective | 35.00 | 9.94 | 114 | 443102 | 7298 | 70477930 |
| Haematotoxicity | 34.98 | 9.94 | 21 | 443195 | 13653 | 70471575 |
| Thrombotic microangiopathy | 34.83 | 9.94 | 36 | 443180 | 17812 | 70467416 |
| Emotional distress | 34.43 | 9.94 | 118 | 443098 | 37070 | 70448158 |
| Sepsis | 34.18 | 9.94 | 1217 | 441999 | 243328 | 70241900 |
| Deep vein thrombosis | 34.16 | 9.94 | 488 | 442728 | 110554 | 70374674 |
| Chronic kidney disease | 34.15 | 9.94 | 232 | 442984 | 60825 | 70424403 |
| Osteonecrosis of jaw | 34.09 | 9.94 | 136 | 443080 | 40866 | 70444362 |
| Wheelchair user | 34.03 | 9.94 | 90 | 443126 | 5124 | 70480104 |
| Eosinophilia | 33.99 | 9.94 | 133 | 443083 | 40186 | 70445042 |
| Acute graft versus host disease | 33.72 | 9.94 | 9 | 443207 | 9553 | 70475675 |
| Subdural haematoma | 33.64 | 9.94 | 84 | 443132 | 29214 | 70456014 |
| Immunodeficiency | 33.52 | 9.94 | 206 | 443010 | 17349 | 70467879 |
| Accidental overdose | 33.50 | 9.94 | 110 | 443106 | 35011 | 70450217 |
| Unintentional medical device removal | 33.43 | 9.94 | 3 | 443213 | 7121 | 70478107 |
| Mouth ulceration | 33.39 | 9.94 | 345 | 442871 | 34004 | 70451224 |
| Status epilepticus | 33.38 | 9.94 | 64 | 443152 | 24462 | 70460766 |
| Graft versus host disease | 33.24 | 9.94 | 27 | 443189 | 14996 | 70470232 |
| Exostosis | 33.07 | 9.94 | 177 | 443039 | 14168 | 70471060 |
| Oral herpes | 32.75 | 9.94 | 261 | 442955 | 23925 | 70461303 |
| Wrong technique in product usage process | 32.74 | 9.94 | 273 | 442943 | 68425 | 70416803 |
| Haemoptysis | 32.65 | 9.94 | 188 | 443028 | 51264 | 70433964 |
| Ischaemic stroke | 32.63 | 9.94 | 92 | 443124 | 30728 | 70454500 |
| Tenosynovitis stenosans | 32.61 | 9.94 | 55 | 443161 | 2278 | 70482950 |
| Dysarthria | 32.31 | 9.94 | 242 | 442974 | 62071 | 70423157 |
| Bradyphrenia | 32.11 | 9.94 | 11 | 443205 | 9935 | 70475293 |
| Tuberculosis | 32.08 | 9.94 | 180 | 443036 | 14668 | 70470560 |
| Forced expiratory volume decreased | 31.96 | 9.94 | 4 | 443212 | 7310 | 70477918 |
| Blood alkaline phosphatase increased | 31.92 | 9.94 | 224 | 442992 | 58297 | 70426931 |
| Urticaria | 31.91 | 9.94 | 775 | 442441 | 162274 | 70322954 |
| Spinal stenosis | 31.90 | 9.94 | 178 | 443038 | 14475 | 70470753 |
| White blood cell count decreased | 31.86 | 9.94 | 814 | 442402 | 169327 | 70315901 |
| Dystonia | 31.85 | 9.94 | 46 | 443170 | 19660 | 70465568 |
| Platelet count decreased | 31.71 | 9.94 | 859 | 442357 | 177363 | 70307865 |
| Acute respiratory failure | 31.48 | 9.94 | 201 | 443015 | 53464 | 70431764 |
| Tachypnoea | 31.43 | 9.94 | 84 | 443132 | 28554 | 70456674 |
| Fear | 31.31 | 9.94 | 51 | 443165 | 20760 | 70464468 |
| Panniculitis | 31.24 | 9.94 | 141 | 443075 | 10535 | 70474693 |
| Dyskinesia | 31.22 | 9.94 | 141 | 443075 | 40933 | 70444295 |
| BK virus infection | 31.21 | 9.94 | 6 | 443210 | 7983 | 70477245 |
| Leukocytosis | 30.86 | 9.94 | 135 | 443081 | 39533 | 70445695 |
| Joint noise | 30.79 | 9.94 | 67 | 443149 | 3364 | 70481864 |
| Lip dry | 30.73 | 9.94 | 132 | 443084 | 9653 | 70475575 |
| Toxic epidermal necrolysis | 30.54 | 9.94 | 135 | 443081 | 39422 | 70445806 |
| Blood bilirubin increased | 30.41 | 9.94 | 234 | 442982 | 59667 | 70425561 |
| Bone disorder | 30.16 | 9.94 | 200 | 443016 | 17290 | 70467938 |
| Haemorrhage intracranial | 30.07 | 9.94 | 69 | 443147 | 24708 | 70460520 |
| Gastroenteritis viral | 29.86 | 9.94 | 233 | 442983 | 21222 | 70464006 |
| Ulcer | 29.63 | 9.94 | 268 | 442948 | 25486 | 70459742 |
| Foot fracture | 29.61 | 9.94 | 217 | 442999 | 19383 | 70465845 |
| Bronchitis | 29.52 | 9.94 | 950 | 442266 | 116293 | 70368935 |
| Retinitis | 29.41 | 9.94 | 74 | 443142 | 4086 | 70481142 |
| Ventricular fibrillation | 29.40 | 9.94 | 80 | 443136 | 27031 | 70458197 |
| Acute respiratory distress syndrome | 29.37 | 9.94 | 145 | 443071 | 41109 | 70444119 |
| Skin papilloma | 29.09 | 9.94 | 87 | 443129 | 5319 | 70479909 |
| Hyperthermia | 28.88 | 9.94 | 37 | 443179 | 16634 | 70468594 |
| Mania | 28.85 | 9.94 | 39 | 443177 | 17135 | 70468093 |
| Tumour lysis syndrome | 28.84 | 9.94 | 56 | 443160 | 21304 | 70463924 |
| Synovial fluid analysis | 28.74 | 9.94 | 46 | 443170 | 1823 | 70483405 |
| Rotator cuff repair | 28.70 | 9.94 | 43 | 443173 | 1608 | 70483620 |
| Hypertransaminasaemia | 28.68 | 9.94 | 10 | 443206 | 8933 | 70476295 |
| Hallucination, visual | 28.60 | 9.94 | 91 | 443125 | 29246 | 70455982 |
| Haemorrhage | 28.44 | 9.94 | 361 | 442855 | 83454 | 70401774 |
| Peripheral venous disease | 28.23 | 9.94 | 137 | 443079 | 10550 | 70474678 |
| Dysgeusia | 28.23 | 9.94 | 187 | 443029 | 49315 | 70435913 |
| Pleural effusion | 28.10 | 9.94 | 624 | 442592 | 132240 | 70352988 |
| Colorectal cancer | 27.98 | 9.94 | 9 | 443207 | 8461 | 70476767 |
| Acute generalised exanthematous pustulosis | 27.91 | 9.94 | 33 | 443183 | 15364 | 70469864 |
| Loose body in joint | 27.65 | 9.94 | 37 | 443179 | 1244 | 70483984 |
| Shock haemorrhagic | 27.59 | 9.94 | 44 | 443172 | 18062 | 70467166 |
| Acute chest syndrome | 27.52 | 9.94 | 32 | 443184 | 930 | 70484298 |
| Influenza | 27.51 | 9.94 | 917 | 442299 | 112783 | 70372445 |
| Chest discomfort | 27.50 | 9.94 | 580 | 442636 | 123801 | 70361427 |
| Aphasia | 27.46 | 9.94 | 158 | 443058 | 43091 | 70442137 |
| Muscle spasms | 27.26 | 9.94 | 743 | 442473 | 153303 | 70331925 |
| Acidosis | 27.25 | 9.94 | 45 | 443171 | 18218 | 70467010 |
| Jaundice | 27.23 | 9.94 | 192 | 443024 | 49916 | 70435312 |
| Skin cancer | 27.22 | 9.94 | 161 | 443055 | 13375 | 70471853 |
| Pancytopenia | 27.09 | 9.94 | 1179 | 442037 | 149928 | 70335300 |
| Facet joint syndrome | 27.07 | 9.94 | 92 | 443124 | 6021 | 70479207 |
| Respiratory disorder | 27.00 | 9.94 | 139 | 443077 | 38984 | 70446244 |
| Pulmonary hypertension | 26.94 | 9.94 | 175 | 443041 | 46361 | 70438867 |
| Clostridium difficile colitis | 26.85 | 9.94 | 92 | 443124 | 28904 | 70456324 |
| Acute myeloid leukaemia | 26.77 | 9.94 | 101 | 443115 | 30839 | 70454389 |
| Polyneuropathy | 26.51 | 9.94 | 59 | 443157 | 21356 | 70463872 |
| Pulmonary alveolar haemorrhage | 26.42 | 9.94 | 16 | 443200 | 10353 | 70474875 |
| Injection site warmth | 26.25 | 9.94 | 162 | 443054 | 13663 | 70471565 |
| Therapy non-responder | 25.98 | 9.94 | 647 | 442569 | 76268 | 70408960 |
| Haemophagocytic lymphohistiocytosis | 25.98 | 9.94 | 52 | 443164 | 19560 | 70465668 |
| Glycosylated haemoglobin increased | 25.81 | 9.94 | 43 | 443173 | 17348 | 70467880 |
| Pancreatitis acute | 25.71 | 9.94 | 171 | 443045 | 45053 | 70440175 |
| Sciatica | 25.69 | 9.94 | 251 | 442965 | 24376 | 70460852 |
| Angina pectoris | 25.51 | 9.94 | 187 | 443029 | 48196 | 70437032 |
| Dyspnoea exertional | 25.43 | 9.94 | 341 | 442875 | 78089 | 70407139 |
| Anaphylactic reaction | 25.40 | 9.94 | 323 | 442893 | 74651 | 70410577 |
| Scleritis | 25.16 | 9.94 | 64 | 443152 | 3558 | 70481670 |
| Product administration error | 25.14 | 9.94 | 97 | 443119 | 29426 | 70455802 |
| Respiration abnormal | 25.09 | 9.94 | 6 | 443210 | 6858 | 70478370 |
| Dysphagia | 24.99 | 9.94 | 526 | 442690 | 112308 | 70372920 |
| Aspartate aminotransferase increased | 24.99 | 9.94 | 603 | 442613 | 126375 | 70358853 |
| Surgery | 24.92 | 9.94 | 292 | 442924 | 29697 | 70455531 |
| Hallucination, auditory | 24.79 | 9.94 | 48 | 443168 | 18280 | 70466948 |
| Potentiating drug interaction | 24.72 | 9.94 | 10 | 443206 | 8154 | 70477074 |
| Acute graft versus host disease in skin | 24.64 | 9.94 | 7 | 443209 | 7130 | 70478098 |
| Dislocation of vertebra | 24.63 | 9.94 | 77 | 443139 | 4823 | 70480405 |
| Malignant melanoma | 24.61 | 9.94 | 160 | 443056 | 13740 | 70471488 |
| Stevens-Johnson syndrome | 24.54 | 9.94 | 128 | 443088 | 35779 | 70449449 |
| Klebsiella infection | 24.47 | 9.94 | 32 | 443184 | 14260 | 70470968 |
| Cardiac failure acute | 24.35 | 9.94 | 45 | 443171 | 17442 | 70467786 |
| Foetal death | 24.28 | 9.94 | 90 | 443126 | 6149 | 70479079 |
| Vertigo | 24.27 | 9.94 | 262 | 442954 | 62381 | 70422847 |
| Graft versus host disease in gastrointestinal tract | 24.23 | 9.94 | 4 | 443212 | 5940 | 70479288 |
| Oxygen saturation decreased | 24.22 | 9.94 | 923 | 442293 | 115506 | 70369722 |
| Fracture delayed union | 24.21 | 9.94 | 45 | 443171 | 2014 | 70483214 |
| Blood pressure decreased | 24.15 | 9.94 | 414 | 442802 | 91101 | 70394127 |
| Flushing | 23.92 | 9.94 | 365 | 442851 | 81807 | 70403421 |
| Pneumatosis intestinalis | 23.91 | 9.94 | 4 | 443212 | 5883 | 70479345 |
| Drug tolerance decreased | 23.82 | 9.94 | 123 | 443093 | 9710 | 70475518 |
| Endophthalmitis | 23.81 | 9.94 | 5 | 443211 | 6250 | 70478978 |
| Nightmare | 23.56 | 9.94 | 66 | 443150 | 22090 | 70463138 |
| Delusion | 23.56 | 9.94 | 53 | 443163 | 19112 | 70466116 |
| Schizophrenia | 23.49 | 9.94 | 43 | 443173 | 16725 | 70468503 |
| Cytomegalovirus viraemia | 23.45 | 9.94 | 23 | 443193 | 11662 | 70473566 |
| Post procedural infection | 23.36 | 9.94 | 127 | 443089 | 10226 | 70475002 |
| Bone pain | 23.30 | 9.94 | 204 | 443012 | 50618 | 70434610 |
| Face oedema | 23.30 | 9.94 | 82 | 443134 | 25557 | 70459671 |
| Hypomagnesaemia | 23.24 | 9.94 | 154 | 443062 | 40610 | 70444618 |
| Hepatitis B reactivation | 23.23 | 9.94 | 3 | 443213 | 5352 | 70479876 |
| Rhinorrhoea | 23.23 | 9.94 | 561 | 442655 | 65810 | 70419418 |
| Anhedonia | 23.15 | 9.94 | 33 | 443183 | 14180 | 70471048 |
| Sinus tachycardia | 23.12 | 9.94 | 121 | 443095 | 33792 | 70451436 |
| Polyhydramnios | 23.07 | 9.94 | 37 | 443179 | 1469 | 70483759 |
| Tardive dyskinesia | 23.04 | 9.94 | 17 | 443199 | 9912 | 70475316 |
| Toxic skin eruption | 23 | 9.94 | 58 | 443158 | 20104 | 70465124 |
| Hemiplegia | 22.89 | 9.94 | 32 | 443184 | 13863 | 70471365 |
| Cytopenia | 22.89 | 9.94 | 46 | 443170 | 17277 | 70467951 |
| Pancreatitis | 22.74 | 9.94 | 266 | 442950 | 62402 | 70422826 |
| Stress cardiomyopathy | 22.73 | 9.94 | 17 | 443199 | 9845 | 70475383 |
| Hyperbilirubinaemia | 22.71 | 9.94 | 69 | 443147 | 22499 | 70462729 |
| Hepatic encephalopathy | 22.70 | 9.94 | 67 | 443149 | 22051 | 70463177 |
| Anti-cyclic citrullinated peptide antibody | 22.68 | 9.94 | 59 | 443157 | 3326 | 70481902 |
| Muscle rigidity | 22.58 | 9.94 | 52 | 443164 | 18598 | 70466630 |
| Device use error | 22.33 | 9.94 | 7 | 443209 | 6689 | 70478539 |
| Urinary retention | 22.27 | 9.94 | 215 | 443001 | 52305 | 70432923 |
| Cardiomyopathy | 22.23 | 9.94 | 87 | 443129 | 26286 | 70458942 |
| Device difficult to use | 22.19 | 9.94 | 21 | 443195 | 10828 | 70474400 |
| Hyperammonaemia | 22.15 | 9.94 | 19 | 443197 | 10274 | 70474954 |
| Antinuclear antibody positive | 22.10 | 9.94 | 93 | 443123 | 6740 | 70478488 |
| Therapeutic product effect incomplete | 22.07 | 9.94 | 938 | 442278 | 118944 | 70366284 |
| Disease recurrence | 21.97 | 9.94 | 141 | 443075 | 37462 | 70447766 |
| Nocardiosis | 21.95 | 9.94 | 3 | 443213 | 5126 | 70480102 |
| Blood calcium decreased | 21.94 | 9.94 | 99 | 443117 | 28747 | 70456481 |
| Cyanosis | 21.91 | 9.94 | 73 | 443143 | 23133 | 70462095 |
| Malignant mediastinal neoplasm | 21.59 | 9.94 | 27 | 443189 | 848 | 70484380 |
| Exposure to toxic agent | 21.52 | 9.94 | 6 | 443210 | 6188 | 70479040 |
| Muscle spasticity | 21.42 | 9.94 | 58 | 443158 | 19631 | 70465597 |
| Febrile bone marrow aplasia | 21.41 | 9.94 | 26 | 443190 | 11965 | 70473263 |
| Metastases to bone | 21.40 | 9.94 | 70 | 443146 | 22306 | 70462922 |
| Progressive multifocal leukoencephalopathy | 21.36 | 9.94 | 56 | 443160 | 19158 | 70466070 |
| Pleuritic pain | 21.35 | 9.94 | 111 | 443105 | 8786 | 70476442 |
| Chest pain | 21.31 | 9.94 | 1319 | 441897 | 249941 | 70235287 |
| Adenovirus infection | 21.21 | 9.94 | 11 | 443205 | 7757 | 70477471 |
| Epstein-Barr virus infection | 21.14 | 9.94 | 31 | 443185 | 13167 | 70472061 |
| Pain in jaw | 21.04 | 9.94 | 168 | 443048 | 42501 | 70442727 |
| Breast cancer stage I | 21.04 | 9.94 | 6 | 443210 | 6096 | 70479132 |
| Synovial disorder | 21.02 | 9.94 | 30 | 443186 | 1073 | 70484155 |
| Postoperative wound infection | 20.99 | 9.94 | 132 | 443084 | 11206 | 70474022 |
| Chronic graft versus host disease | 20.98 | 9.94 | 8 | 443208 | 6762 | 70478466 |
| Polyuria | 20.98 | 9.94 | 32 | 443184 | 13374 | 70471854 |
| Adjustment disorder with depressed mood | 20.89 | 9.94 | 66 | 443150 | 4157 | 70481071 |
| Cystitis haemorrhagic | 20.88 | 9.94 | 14 | 443202 | 8579 | 70476649 |
| Cardiac failure chronic | 20.86 | 9.94 | 20 | 443196 | 10249 | 70474979 |
| Haematoma | 20.62 | 9.94 | 198 | 443018 | 48220 | 70437008 |
| Lipase increased | 20.56 | 9.94 | 40 | 443176 | 15206 | 70470022 |
| Hemiparesis | 20.50 | 9.94 | 114 | 443102 | 31355 | 70453873 |
| Dactylitis | 20.49 | 9.94 | 44 | 443172 | 2189 | 70483039 |
| Acute coronary syndrome | 20.48 | 9.94 | 61 | 443155 | 20018 | 70465210 |
| Hyperuricaemia | 20.42 | 9.94 | 23 | 443193 | 10943 | 70474285 |
| Rebound effect | 20.35 | 9.94 | 6 | 443210 | 5965 | 70479263 |
| Pulseless electrical activity | 20.24 | 9.94 | 32 | 443184 | 13183 | 70472045 |
| Hypervolaemia | 20.20 | 9.94 | 155 | 443061 | 39551 | 70445677 |
| Atrioventricular block | 20.13 | 9.94 | 30 | 443186 | 12658 | 70472570 |
| Acute myocardial infarction | 20.13 | 9.94 | 327 | 442889 | 72560 | 70412668 |
| Musculoskeletal disorder | 20.08 | 9.94 | 202 | 443014 | 19769 | 70465459 |
| Bronchospasm | 19.98 | 9.94 | 74 | 443142 | 22718 | 70462510 |
| Endodontic procedure | 19.93 | 9.94 | 47 | 443169 | 2490 | 70482738 |
| Rheumatoid lung | 19.89 | 9.94 | 57 | 443159 | 3402 | 70481826 |
| Sinus bradycardia | 19.86 | 9.94 | 78 | 443138 | 23545 | 70461683 |
| Peripheral sensory neuropathy | 19.84 | 9.94 | 28 | 443188 | 12082 | 70473146 |
| Affective disorder | 19.82 | 9.94 | 11 | 443205 | 7468 | 70477760 |
| Myelosuppression | 19.75 | 9.94 | 109 | 443107 | 30036 | 70455192 |
| Pyrexia | 19.73 | 9.94 | 3414 | 439802 | 603538 | 69881690 |
| Feeling abnormal | 19.70 | 9.94 | 709 | 442507 | 141610 | 70343618 |
| Cushingoid | 19.68 | 9.94 | 104 | 443112 | 8284 | 70476944 |
| Palpitations | 19.64 | 9.94 | 534 | 442682 | 110219 | 70375009 |
| Breast feeding | 19.63 | 9.94 | 23 | 443193 | 674 | 70484554 |
| Pemphigoid | 19.60 | 9.94 | 36 | 443180 | 13986 | 70471242 |
| Weight decreased | 19.50 | 9.94 | 2221 | 440995 | 308267 | 70176961 |
| Foetal distress syndrome | 19.48 | 9.94 | 19 | 443197 | 449 | 70484779 |
| Hepatocellular carcinoma | 19.46 | 9.94 | 21 | 443195 | 10187 | 70475041 |
| Hyperlactacidaemia | 19.42 | 9.94 | 4 | 443212 | 5068 | 70480160 |
| Visual acuity reduced | 19.41 | 9.94 | 99 | 443117 | 27831 | 70457397 |
| Renal injury | 19.38 | 9.94 | 45 | 443171 | 16049 | 70469179 |
| Myopathy | 19.38 | 9.94 | 56 | 443160 | 18556 | 70466672 |
| Human antichimeric antibody positive | 19.35 | 9.94 | 34 | 443182 | 1456 | 70483772 |
| Tubulointerstitial nephritis | 19.34 | 9.94 | 124 | 443092 | 32952 | 70452276 |
| Stillbirth | 19.32 | 9.94 | 60 | 443156 | 3745 | 70481483 |
| Ingrown hair | 19.18 | 9.94 | 22 | 443194 | 630 | 70484598 |
| Blood lactic acid increased | 19.15 | 9.94 | 25 | 443191 | 11148 | 70474080 |
| Oliguria | 19.01 | 9.94 | 41 | 443175 | 15010 | 70470218 |
| Muscle twitching | 18.98 | 9.94 | 62 | 443154 | 19765 | 70465463 |
| Metastases to liver | 18.97 | 9.94 | 90 | 443126 | 25788 | 70459440 |
| Sexual dysfunction | 18.94 | 9.94 | 9 | 443207 | 6672 | 70478556 |
| Electrocardiogram QRS complex prolonged | 18.88 | 9.94 | 20 | 443196 | 9786 | 70475442 |
| Labelled drug-drug interaction medication error | 18.83 | 9.94 | 82 | 443134 | 24045 | 70461183 |
| Pharyngitis streptococcal | 18.76 | 9.94 | 112 | 443104 | 9336 | 70475892 |
| Interstitial lung disease | 18.75 | 9.94 | 504 | 442712 | 104181 | 70381047 |
| Polydipsia | 18.69 | 9.94 | 7 | 443209 | 5981 | 70479247 |
| Lymphocyte count decreased | 18.56 | 9.94 | 178 | 443038 | 43361 | 70441867 |
| Gastric haemorrhage | 18.46 | 9.94 | 38 | 443178 | 14147 | 70471081 |
| Wound infection | 18.40 | 9.94 | 179 | 443037 | 17363 | 70467865 |
| Incorrect route of product administration | 18.35 | 9.94 | 94 | 443122 | 26398 | 70458830 |
| Pulmonary congestion | 18.14 | 9.94 | 88 | 443128 | 25066 | 70460162 |
| Bacteraemia | 18.11 | 9.94 | 108 | 443108 | 29201 | 70456027 |
| End stage renal disease | 17.98 | 9.94 | 26 | 443190 | 11107 | 70474121 |
| Anger | 17.95 | 9.94 | 47 | 443169 | 16085 | 70469143 |
| Ileus | 17.94 | 9.94 | 84 | 443132 | 24153 | 70461075 |
| Hyperprolactinaemia | 17.92 | 9.94 | 3 | 443213 | 4410 | 70480818 |
| Onychomycosis | 17.89 | 9.94 | 88 | 443128 | 6813 | 70478415 |
| Hyperthyroidism | 17.76 | 9.94 | 65 | 443151 | 20026 | 70465202 |
| Foetal exposure during pregnancy | 17.61 | 9.94 | 76 | 443140 | 5569 | 70479659 |
| Induced labour | 17.51 | 9.94 | 24 | 443192 | 826 | 70484402 |
| Skin necrosis | 17.47 | 9.94 | 167 | 443049 | 16124 | 70469104 |
| Haematocrit decreased | 17.41 | 9.94 | 475 | 442741 | 56783 | 70428445 |
| Multiple sclerosis | 17.36 | 9.94 | 90 | 443126 | 25195 | 70460033 |
| Toxic encephalopathy | 17.11 | 9.94 | 24 | 443192 | 10382 | 70474846 |
| Anuria | 17.10 | 9.94 | 64 | 443152 | 19589 | 70465639 |
| Heart rate irregular | 17.07 | 9.94 | 271 | 442945 | 29472 | 70455756 |
| Body height below normal | 17.00 | 9.94 | 37 | 443179 | 1858 | 70483370 |
| Hepatitis fulminant | 16.98 | 9.94 | 10 | 443206 | 6571 | 70478657 |
| Coordination abnormal | 16.98 | 9.94 | 48 | 443168 | 16018 | 70469210 |
| Nephropathy toxic | 16.96 | 9.94 | 59 | 443157 | 18455 | 70466773 |
| Lacrimal disorder | 16.92 | 9.94 | 18 | 443198 | 473 | 70484755 |
| Paralysis | 16.87 | 9.94 | 31 | 443185 | 12041 | 70473187 |
| Presyncope | 16.84 | 9.94 | 151 | 443065 | 37287 | 70447941 |
| Device leakage | 16.82 | 9.94 | 20 | 443196 | 9288 | 70475940 |
| Hypoalbuminaemia | 16.82 | 9.94 | 62 | 443154 | 19060 | 70466168 |
| Haemorrhage in pregnancy | 16.80 | 9.94 | 30 | 443186 | 1301 | 70483927 |
| Cholangitis | 16.73 | 9.94 | 29 | 443187 | 11520 | 70473708 |
| Placental disorder | 16.66 | 9.94 | 24 | 443192 | 866 | 70484362 |
| Respiratory acidosis | 16.61 | 9.94 | 24 | 443192 | 10257 | 70474971 |
| Deep vein thrombosis postoperative | 16.60 | 9.94 | 55 | 443161 | 3552 | 70481676 |
| Coronary arterial stent insertion | 16.58 | 9.94 | 8 | 443208 | 5879 | 70479349 |
| Metastases to central nervous system | 16.57 | 9.94 | 44 | 443172 | 14990 | 70470238 |
| Ankle arthroplasty | 16.56 | 9.94 | 28 | 443188 | 1162 | 70484066 |
| Obesity | 16.55 | 9.94 | 247 | 442969 | 26524 | 70458704 |
| Off label use | 16.52 | 9.94 | 4259 | 438957 | 738801 | 69746427 |
| Persecutory delusion | 16.41 | 9.94 | 4 | 443212 | 4513 | 70480715 |
| Dermatitis acneiform | 16.40 | 9.94 | 19 | 443197 | 8926 | 70476302 |
| Upper respiratory tract infection | 16.38 | 9.94 | 628 | 442588 | 78646 | 70406582 |
| Hypophosphataemia | 16.36 | 9.94 | 50 | 443166 | 16276 | 70468952 |
| Catatonia | 16.33 | 9.94 | 16 | 443200 | 8117 | 70477111 |
| Tuberculin test positive | 16.31 | 9.94 | 51 | 443165 | 3195 | 70482033 |
| Lethargy | 16.31 | 9.94 | 352 | 442864 | 74898 | 70410330 |
| Frequent bowel movements | 16.28 | 9.94 | 203 | 443013 | 20950 | 70464278 |
| Septic shock | 16.28 | 9.94 | 556 | 442660 | 111702 | 70373526 |
| Erectile dysfunction | 16.27 | 9.94 | 38 | 443178 | 13524 | 70471704 |
| Spinal disorder | 16.24 | 9.94 | 106 | 443110 | 9114 | 70476114 |
| Enterocolitis | 16.17 | 9.94 | 36 | 443180 | 13030 | 70472198 |
| General physical health deterioration | 16.14 | 9.94 | 1698 | 441518 | 234333 | 70250895 |
| Myocardial ischaemia | 16.13 | 9.94 | 87 | 443129 | 24113 | 70461115 |
| Hepatitis C | 16.08 | 9.94 | 35 | 443181 | 12772 | 70472456 |
| Bradypnoea | 16.03 | 9.94 | 7 | 443209 | 5452 | 70479776 |
| Temperature regulation disorder | 16.02 | 9.94 | 4 | 443212 | 4440 | 70480788 |
| Purpura | 15.99 | 9.94 | 58 | 443158 | 17917 | 70467311 |
| Dyslipidaemia | 15.95 | 9.94 | 23 | 443193 | 9837 | 70475391 |
| Alcohol abuse | 15.89 | 9.94 | 6 | 443210 | 5101 | 70480127 |
| Myocarditis | 15.84 | 9.94 | 62 | 443154 | 18731 | 70466497 |
| Tooth infection | 15.83 | 9.94 | 165 | 443051 | 16298 | 70468930 |
| Antibody test positive | 15.83 | 9.94 | 43 | 443173 | 2488 | 70482740 |
| Sickle cell anaemia | 15.82 | 9.94 | 20 | 443196 | 635 | 70484593 |
| Heparin-induced thrombocytopenia | 15.71 | 9.94 | 20 | 443196 | 9017 | 70476211 |
| Alanine aminotransferase increased | 15.69 | 9.94 | 757 | 442459 | 146723 | 70338505 |
| Lymphatic fistula | 15.60 | 9.94 | 22 | 443194 | 778 | 70484450 |
| Mass | 15.59 | 9.94 | 161 | 443055 | 15865 | 70469363 |
| Cyst | 15.48 | 9.94 | 134 | 443082 | 12585 | 70472643 |
| Metastases to lung | 15.46 | 9.94 | 52 | 443164 | 16432 | 70468796 |
| Product prescribing error | 15.46 | 9.94 | 162 | 443054 | 38790 | 70446438 |
| Femoral hernia incarcerated | 15.45 | 9.94 | 22 | 443194 | 785 | 70484443 |
| Wound infection pseudomonas | 15.45 | 9.94 | 32 | 443184 | 1552 | 70483676 |
| Normal newborn | 15.39 | 9.94 | 79 | 443137 | 6221 | 70479007 |
| Prostatic specific antigen increased | 15.39 | 9.94 | 22 | 443194 | 9444 | 70475784 |
| Labyrinthitis | 15.36 | 9.94 | 45 | 443171 | 2719 | 70482509 |
| Intracranial pressure increased | 15.32 | 9.94 | 14 | 443202 | 7342 | 70477886 |
| Memory impairment | 15.32 | 9.94 | 451 | 442765 | 92190 | 70393038 |
| Hepatitis acute | 15.29 | 9.94 | 41 | 443175 | 13921 | 70471307 |
| Paranoia | 15.24 | 9.94 | 56 | 443160 | 17232 | 70467996 |
| Lung transplant | 15.20 | 9.94 | 4 | 443212 | 4286 | 70480942 |
| Troponin increased | 15.19 | 9.94 | 53 | 443163 | 16561 | 70468667 |
| Hypothyroidism | 15.17 | 9.94 | 198 | 443018 | 45557 | 70439671 |
| Pseudomonas infection | 15.17 | 9.94 | 64 | 443152 | 18930 | 70466298 |
| Incoherent | 15.11 | 9.94 | 14 | 443202 | 7292 | 70477936 |
| Aphthous ulcer | 15.11 | 9.94 | 149 | 443067 | 14507 | 70470721 |
| Pneumothorax | 15.06 | 9.94 | 97 | 443119 | 25749 | 70459479 |
| Erythema multiforme | 15.03 | 9.94 | 53 | 443163 | 16511 | 70468717 |
| Finger deformity | 15.03 | 9.94 | 77 | 443139 | 6059 | 70479169 |
| Drug abuser | 15.01 | 9.94 | 9 | 443207 | 5855 | 70479373 |
| Pulmonary tuberculosis | 14.94 | 9.94 | 92 | 443124 | 7753 | 70477475 |
| Hypocalcaemia | 14.92 | 9.94 | 194 | 443022 | 44665 | 70440563 |
| Unevaluable event | 14.90 | 9.94 | 232 | 442984 | 51831 | 70433397 |
| Drug screen positive | 14.90 | 9.94 | 9 | 443207 | 5831 | 70479397 |
| Right ventricular failure | 14.89 | 9.94 | 80 | 443136 | 22194 | 70463034 |
| Acute lymphocytic leukaemia recurrent | 14.86 | 9.94 | 6 | 443210 | 4898 | 70480330 |
| Ankylosing spondylitis | 14.86 | 9.94 | 124 | 443092 | 11522 | 70473706 |
| Foot operation | 14.85 | 9.94 | 65 | 443151 | 4792 | 70480436 |
| Virologic failure | 14.81 | 9.94 | 3 | 443213 | 3847 | 70481381 |
| Haematemesis | 14.81 | 9.94 | 215 | 443001 | 48582 | 70436646 |
| Atrioventricular block complete | 14.80 | 9.94 | 47 | 443169 | 15116 | 70470112 |
| Radiation inflammation | 14.78 | 9.94 | 18 | 443198 | 550 | 70484678 |
| Hepatitis cholestatic | 14.73 | 9.94 | 36 | 443180 | 12614 | 70472614 |
| Placental insufficiency | 14.64 | 9.94 | 25 | 443191 | 1046 | 70484182 |
| Transplant dysfunction | 14.57 | 9.94 | 13 | 443203 | 6896 | 70478332 |
| Cervical incompetence | 14.54 | 9.94 | 17 | 443199 | 497 | 70484731 |
| Amylase increased | 14.46 | 9.94 | 26 | 443190 | 10182 | 70475046 |
| Injection site haemorrhage | 14.43 | 9.94 | 232 | 442984 | 25295 | 70459933 |
| Taste disorder | 14.39 | 9.94 | 31 | 443185 | 11354 | 70473874 |
| Pulmonary haemorrhage | 14.34 | 9.94 | 41 | 443175 | 13632 | 70471596 |
| Knee operation | 14.28 | 9.94 | 66 | 443150 | 4981 | 70480247 |
| Obstructive airways disorder | 14.21 | 9.94 | 100 | 443116 | 26013 | 70459215 |
| Hyperlipidaemia | 14.19 | 9.94 | 89 | 443127 | 23774 | 70461454 |
| Anal fistula | 14.19 | 9.94 | 75 | 443141 | 5975 | 70479253 |
| Glomerular filtration rate decreased | 14.18 | 9.94 | 74 | 443142 | 20682 | 70464546 |
| Cardiotoxicity | 14.11 | 9.94 | 30 | 443186 | 11040 | 70474188 |
| Left ventricular dysfunction | 14.03 | 9.94 | 61 | 443155 | 17896 | 70467332 |
| Bone density abnormal | 14.03 | 9.94 | 45 | 443171 | 2858 | 70482370 |
| Mental disorder | 14.01 | 9.94 | 111 | 443105 | 28129 | 70457099 |
| Red blood cell count decreased | 14.00 | 9.94 | 426 | 442790 | 51735 | 70433493 |
| Transaminases increased | 13.98 | 9.94 | 208 | 443008 | 46810 | 70438418 |
| Breast cancer stage II | 13.97 | 9.94 | 8 | 443208 | 5338 | 70479890 |
| Type 1 diabetes mellitus | 13.96 | 9.94 | 11 | 443205 | 6203 | 70479025 |
| Hydrocephalus | 13.95 | 9.94 | 18 | 443198 | 8067 | 70477161 |
| Generalised tonic-clonic seizure | 13.92 | 9.94 | 180 | 443036 | 41481 | 70443747 |
| Complication of device insertion | 13.91 | 9.94 | 8 | 443208 | 5324 | 70479904 |
| Motor dysfunction | 13.85 | 9.94 | 39 | 443177 | 13031 | 70472197 |
| Injection site urticaria | 13.84 | 9.94 | 122 | 443094 | 11516 | 70473712 |
| Abortion threatened | 13.83 | 9.94 | 15 | 443201 | 403 | 70484825 |
| Human anti-human antibody test | 13.77 | 9.94 | 15 | 443201 | 405 | 70484823 |
| Lip swelling | 13.77 | 9.94 | 141 | 443075 | 33913 | 70451315 |
| Gestational hypertension | 13.77 | 9.94 | 33 | 443183 | 1767 | 70483461 |
| Cytomegalovirus chorioretinitis | 13.75 | 9.94 | 8 | 443208 | 5290 | 70479938 |
| Respiratory tract infection viral | 13.71 | 9.94 | 51 | 443165 | 3490 | 70481738 |
| Joint warmth | 13.71 | 9.94 | 30 | 443186 | 1512 | 70483716 |
| Eosinophil count increased | 13.62 | 9.94 | 49 | 443167 | 15173 | 70470055 |
| Haemodynamic instability | 13.62 | 9.94 | 51 | 443165 | 15607 | 70469621 |
| COVID-19 pneumonia | 13.55 | 9.94 | 81 | 443135 | 21888 | 70463340 |
| Kidney transplant rejection | 13.55 | 9.94 | 26 | 443190 | 9935 | 70475293 |
| Epilepsy | 13.54 | 9.94 | 166 | 443050 | 38618 | 70446610 |
| Device related infection | 13.54 | 9.94 | 132 | 443084 | 32053 | 70453175 |
| Arthritis bacterial | 13.51 | 9.94 | 93 | 443123 | 8140 | 70477088 |
| Haemoglobin decreased | 13.47 | 9.94 | 1472 | 441744 | 203687 | 70281541 |
| Tooth abscess | 13.46 | 9.94 | 145 | 443071 | 14444 | 70470784 |
| Drug tolerance | 13.45 | 9.94 | 86 | 443130 | 7342 | 70477886 |
| Spinal osteoarthritis | 13.45 | 9.94 | 151 | 443065 | 15197 | 70470031 |
| Joint lock | 13.44 | 9.94 | 45 | 443171 | 2922 | 70482306 |
| Kidney infection | 13.42 | 9.94 | 183 | 443033 | 19272 | 70465956 |
| Generalised oedema | 13.41 | 9.94 | 80 | 443136 | 21628 | 70463600 |
| Panic attack | 13.41 | 9.94 | 82 | 443134 | 22037 | 70463191 |
| Tooth disorder | 13.32 | 9.94 | 217 | 442999 | 23721 | 70461507 |
| Injection site extravasation | 13.31 | 9.94 | 97 | 443119 | 8649 | 70476579 |
| Brain natriuretic peptide increased | 13.28 | 9.94 | 19 | 443197 | 8152 | 70477076 |
| Iodine allergy | 13.28 | 9.94 | 17 | 443199 | 547 | 70484681 |
| Pulmonary toxicity | 13.26 | 9.94 | 114 | 443102 | 10684 | 70474544 |
| Clear cell renal cell carcinoma | 13.22 | 9.94 | 38 | 443178 | 2272 | 70482956 |
| Bladder cancer | 13.21 | 9.94 | 59 | 443157 | 17183 | 70468045 |
| Blood folate increased | 13.21 | 9.94 | 16 | 443200 | 486 | 70484742 |
| Accidental death | 13.18 | 9.94 | 4 | 443212 | 3904 | 70481324 |
| Oesophageal carcinoma | 13.13 | 9.94 | 24 | 443192 | 9342 | 70475886 |
| Multiple-drug resistance | 13.08 | 9.94 | 16 | 443200 | 7339 | 70477889 |
| Atrial flutter | 13.04 | 9.94 | 74 | 443142 | 20253 | 70464975 |
| Diaphragmatic disorder | 13.01 | 9.94 | 30 | 443186 | 1566 | 70483662 |
| Toothache | 12.98 | 9.94 | 174 | 443042 | 18256 | 70466972 |
| Haemodialysis | 12.97 | 9.94 | 60 | 443156 | 17306 | 70467922 |
| Small for dates baby | 12.95 | 9.94 | 15 | 443201 | 434 | 70484794 |
| Ventricular arrhythmia | 12.93 | 9.94 | 18 | 443198 | 7812 | 70477416 |
| Drug specific antibody | 12.93 | 9.94 | 38 | 443178 | 2301 | 70482927 |
| Immunosuppression | 12.92 | 9.94 | 119 | 443097 | 11373 | 70473855 |
| Hypercapnia | 12.92 | 9.94 | 20 | 443196 | 8309 | 70476919 |
| Breast abscess | 12.91 | 9.94 | 26 | 443190 | 1236 | 70483992 |
| Dry eye | 12.89 | 9.94 | 278 | 442938 | 32004 | 70453224 |
| Hypoxic-ischaemic encephalopathy | 12.89 | 9.94 | 16 | 443200 | 7292 | 70477936 |
| Hypernatraemia | 12.85 | 9.94 | 39 | 443177 | 12722 | 70472506 |
| Arthropod bite | 12.83 | 9.94 | 84 | 443132 | 7231 | 70477997 |
| Insomnia | 12.79 | 9.94 | 1179 | 442037 | 216627 | 70268601 |
| Renal disorder | 12.78 | 9.94 | 164 | 443052 | 37845 | 70447383 |
| Hypertriglyceridaemia | 12.69 | 9.94 | 35 | 443181 | 11776 | 70473452 |
| Ileus paralytic | 12.69 | 9.94 | 22 | 443194 | 8739 | 70476489 |
| Oesophageal fibrosis | 12.68 | 9.94 | 10 | 443206 | 176 | 70485052 |
| Pharyngitis | 12.67 | 9.94 | 188 | 443028 | 20163 | 70465065 |
| Salivary hypersecretion | 12.66 | 9.94 | 40 | 443176 | 12885 | 70472343 |
| Bradykinesia | 12.64 | 9.94 | 17 | 443199 | 7485 | 70477743 |
| Osteoporotic fracture | 12.63 | 9.94 | 52 | 443164 | 3732 | 70481496 |
| Maternal exposure during breast feeding | 12.62 | 9.94 | 37 | 443179 | 2237 | 70482991 |
| Delivery | 12.60 | 9.94 | 17 | 443199 | 576 | 70484652 |
| Cellulitis | 12.60 | 9.94 | 747 | 442469 | 98181 | 70387047 |
| Hepatic cancer | 12.55 | 9.94 | 26 | 443190 | 9657 | 70475571 |
| Uterine perforation | 12.53 | 9.94 | 11 | 443205 | 5880 | 70479348 |
| Epistaxis | 12.50 | 9.94 | 519 | 442697 | 102108 | 70383120 |
| Dementia | 12.49 | 9.94 | 85 | 443131 | 22280 | 70462948 |
| Renal tubular necrosis | 12.48 | 9.94 | 89 | 443127 | 23082 | 70462146 |
| Cholestasis of pregnancy | 12.44 | 9.94 | 22 | 443194 | 947 | 70484281 |
| Peritoneal dialysis complication | 12.40 | 9.94 | 37 | 443179 | 2259 | 70482969 |
| Hepatic cirrhosis | 12.39 | 9.94 | 265 | 442951 | 30466 | 70454762 |
| International normalised ratio increased | 12.37 | 9.94 | 397 | 442819 | 80329 | 70404899 |
| Metastasis | 12.31 | 9.94 | 12 | 443204 | 6102 | 70479126 |
| Pancreatic steatosis | 12.26 | 9.94 | 23 | 443193 | 1037 | 70484191 |
| Electrolyte imbalance | 12.23 | 9.94 | 108 | 443108 | 26753 | 70458475 |
| Strongyloidiasis | 12.22 | 9.94 | 4 | 443212 | 3719 | 70481509 |
| Haematuria | 12.20 | 9.94 | 303 | 442913 | 63270 | 70421958 |
| Hospitalisation | 12.19 | 9.94 | 408 | 442808 | 82160 | 70403068 |
| Ligament rupture | 12.13 | 9.94 | 43 | 443173 | 2874 | 70482354 |
| Pneumonia bacterial | 12.13 | 9.94 | 58 | 443158 | 16583 | 70468645 |
| Alcohol interaction | 12.11 | 9.94 | 7 | 443209 | 4646 | 70480582 |
| C-reactive protein decreased | 12.10 | 9.94 | 38 | 443178 | 2386 | 70482842 |
| Nail injury | 12.09 | 9.94 | 16 | 443200 | 532 | 70484696 |
| Systemic inflammatory response syndrome | 12.08 | 9.94 | 31 | 443185 | 10681 | 70474547 |
| Stress at work | 12.06 | 9.94 | 23 | 443193 | 1050 | 70484178 |
| Mycobacterium tuberculosis complex test positive | 12.04 | 9.94 | 37 | 443179 | 2296 | 70482932 |
| Hernia | 12.04 | 9.94 | 144 | 443072 | 14716 | 70470512 |
| Dry skin | 12.01 | 9.94 | 262 | 442954 | 55669 | 70429559 |
| Lower respiratory tract congestion | 12.00 | 9.94 | 47 | 443169 | 3297 | 70481931 |
| Tendon disorder | 11.96 | 9.94 | 76 | 443140 | 6475 | 70478753 |
| Renal cancer | 11.91 | 9.94 | 36 | 443180 | 11760 | 70473468 |
| Defaecation disorder | 11.87 | 9.94 | 17 | 443199 | 610 | 70484618 |
| Immune thrombocytopenia | 11.84 | 9.94 | 57 | 443159 | 16267 | 70468961 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 11.82 | 9.94 | 3 | 443213 | 3294 | 70481934 |
| COVID-19 | 11.81 | 9.94 | 540 | 442676 | 105217 | 70380011 |
| Liver injury | 11.79 | 9.94 | 338 | 442878 | 40697 | 70444531 |
| Breast cancer metastatic | 11.72 | 9.94 | 29 | 443187 | 10117 | 70475111 |
| Ketoacidosis | 11.72 | 9.94 | 17 | 443199 | 7252 | 70477976 |
| Hepatic cytolysis | 11.71 | 9.94 | 71 | 443145 | 19121 | 70466107 |
| Blood urea increased | 11.69 | 9.94 | 209 | 443007 | 45700 | 70439528 |
| Injection site discolouration | 11.57 | 9.94 | 80 | 443136 | 7012 | 70478216 |
| Complications of transplanted kidney | 11.54 | 9.94 | 12 | 443204 | 5922 | 70479306 |
| Blood potassium increased | 11.53 | 9.94 | 112 | 443104 | 27214 | 70458014 |
| Blood glucose decreased | 11.51 | 9.94 | 96 | 443120 | 24063 | 70461165 |
| Photophobia | 11.50 | 9.94 | 172 | 443044 | 18478 | 70466750 |
| Skin ulcer haemorrhage | 11.49 | 9.94 | 15 | 443201 | 492 | 70484736 |
| Coronary artery bypass | 11.48 | 9.94 | 12 | 443204 | 5908 | 70479320 |
| Skin neoplasm excision | 11.47 | 9.94 | 21 | 443195 | 929 | 70484299 |
| Abortion missed | 11.41 | 9.94 | 24 | 443192 | 1177 | 70484051 |
| Accidental exposure to product | 11.40 | 9.94 | 116 | 443100 | 27935 | 70457293 |
| Graft versus host disease in skin | 11.39 | 9.94 | 11 | 443205 | 5619 | 70479609 |
| Threatened labour | 11.38 | 9.94 | 16 | 443200 | 564 | 70484664 |
| Hepatitis E antibody positive | 11.38 | 9.94 | 11 | 443205 | 257 | 70484971 |
| Intestinal ischaemia | 11.36 | 9.94 | 38 | 443178 | 12026 | 70473202 |
| Lymphoedema | 11.34 | 9.94 | 34 | 443182 | 11135 | 70474093 |
| Blood loss anaemia | 11.32 | 9.94 | 49 | 443167 | 14392 | 70470836 |
| Investigation abnormal | 11.28 | 9.94 | 31 | 443185 | 1806 | 70483422 |
| Multiple drug therapy | 11.26 | 9.94 | 3 | 443213 | 3189 | 70482039 |
| Myofascial pain syndrome | 11.22 | 9.94 | 31 | 443185 | 1811 | 70483417 |
| Sensitivity to weather change | 11.19 | 9.94 | 82 | 443134 | 7323 | 70477905 |
| Lymphopenia | 11.18 | 9.94 | 113 | 443103 | 27246 | 70457982 |
| Ataxia | 11.18 | 9.94 | 92 | 443124 | 23125 | 70462103 |
| Chondropathy | 11.14 | 9.94 | 37 | 443179 | 2393 | 70482835 |
| Post procedural haemorrhage | 11.13 | 9.94 | 42 | 443174 | 12824 | 70472404 |
| Umbilical hernia | 11.11 | 9.94 | 63 | 443153 | 5153 | 70480075 |
| Swollen joint count | 11.11 | 9.94 | 21 | 443195 | 952 | 70484276 |
| Vacuum extractor delivery | 11.06 | 9.94 | 8 | 443208 | 123 | 70485105 |
| Bundle branch block left | 11.04 | 9.94 | 31 | 443185 | 10368 | 70474860 |
| Acute graft versus host disease in intestine | 11.04 | 9.94 | 5 | 443211 | 3811 | 70481417 |
| Sinus congestion | 11.01 | 9.94 | 161 | 443055 | 17212 | 70468016 |
| Depressed mood | 11.00 | 9.94 | 200 | 443016 | 43620 | 70441608 |
| Colitis microscopic | 10.99 | 9.94 | 25 | 443191 | 8980 | 70476248 |
| Hypophagia | 10.98 | 9.94 | 188 | 443028 | 41382 | 70443846 |
| Mental impairment | 10.97 | 9.94 | 63 | 443153 | 17192 | 70468036 |
| Metastases to meninges | 10.97 | 9.94 | 3 | 443213 | 3133 | 70482095 |
| Cross sensitivity reaction | 10.96 | 9.94 | 4 | 443212 | 3474 | 70481754 |
| Cystitis | 10.95 | 9.94 | 377 | 442839 | 46564 | 70438664 |
| Tooth fracture | 10.93 | 9.94 | 108 | 443108 | 10519 | 70474709 |
| Capillary leak syndrome | 10.88 | 9.94 | 4 | 443212 | 3458 | 70481770 |
| Catheter management | 10.87 | 9.94 | 4 | 443212 | 3455 | 70481773 |
| Immune-mediated myositis | 10.86 | 9.94 | 3 | 443213 | 3113 | 70482115 |
| Postpartum haemorrhage | 10.81 | 9.94 | 27 | 443189 | 1484 | 70483744 |
| Skin graft failure | 10.80 | 9.94 | 10 | 443206 | 221 | 70485007 |
| Hypotonia | 10.74 | 9.94 | 38 | 443178 | 11827 | 70473401 |
| Aplasia | 10.69 | 9.94 | 18 | 443198 | 7233 | 70477995 |
| Plasmacytoma | 10.69 | 9.94 | 6 | 443210 | 4048 | 70481180 |
| Skin exfoliation | 10.67 | 9.94 | 227 | 442989 | 48399 | 70436829 |
| Plasma cell myeloma recurrent | 10.67 | 9.94 | 7 | 443209 | 4339 | 70480889 |
| Crying | 10.67 | 9.94 | 83 | 443133 | 21116 | 70464112 |
| Hepatitis E virus test positive | 10.62 | 9.94 | 11 | 443205 | 280 | 70484948 |
| Chills | 10.59 | 9.94 | 770 | 442446 | 144016 | 70341212 |
| Anal fissure | 10.58 | 9.94 | 71 | 443145 | 6162 | 70479066 |
| Abortion incomplete | 10.58 | 9.94 | 3 | 443213 | 3059 | 70482169 |
| Drooling | 10.57 | 9.94 | 11 | 443205 | 5425 | 70479803 |
| Sleep disorder due to a general medical condition | 10.56 | 9.94 | 32 | 443184 | 10444 | 70474784 |
| Mesothelioma | 10.50 | 9.94 | 12 | 443204 | 342 | 70484886 |
| Device dislocation | 10.47 | 9.94 | 90 | 443126 | 22417 | 70462811 |
| Aspiration | 10.47 | 9.94 | 66 | 443150 | 17609 | 70467619 |
| Musculoskeletal discomfort | 10.43 | 9.94 | 163 | 443053 | 17669 | 70467559 |
| Abdominal distension | 10.40 | 9.94 | 541 | 442675 | 104128 | 70381100 |
| Benign ovarian tumour | 10.40 | 9.94 | 11 | 443205 | 287 | 70484941 |
| Pericardial effusion | 10.38 | 9.94 | 191 | 443025 | 41585 | 70443643 |
| Palindromic rheumatism | 10.38 | 9.94 | 13 | 443203 | 409 | 70484819 |
| Nephrotic syndrome | 10.37 | 9.94 | 33 | 443183 | 10607 | 70474621 |
| Hepatitis B | 10.34 | 9.94 | 22 | 443194 | 8092 | 70477136 |
| Short stature | 10.33 | 9.94 | 13 | 443203 | 411 | 70484817 |
| Pseudomembranous colitis | 10.33 | 9.94 | 10 | 443206 | 5101 | 70480127 |
| Hyperpyrexia | 10.31 | 9.94 | 11 | 443205 | 5363 | 70479865 |
| Liver transplant | 10.30 | 9.94 | 7 | 443209 | 4259 | 70480969 |
| Pancreatic duct stenosis | 10.30 | 9.94 | 10 | 443206 | 235 | 70484993 |
| Parkinsonism | 10.27 | 9.94 | 55 | 443161 | 15270 | 70469958 |
| Cerebral haematoma | 10.26 | 9.94 | 19 | 443197 | 7359 | 70477869 |
| Anal skin tags | 10.23 | 9.94 | 13 | 443203 | 415 | 70484813 |
| Faecal calprotectin increased | 10.23 | 9.94 | 55 | 443161 | 4410 | 70480818 |
| Embolism | 10.22 | 9.94 | 44 | 443172 | 12944 | 70472284 |
| Acute pulmonary oedema | 10.22 | 9.94 | 46 | 443170 | 13366 | 70471862 |
| Laryngospasm | 10.19 | 9.94 | 5 | 443211 | 3638 | 70481590 |
| Excessive cerumen production | 10.16 | 9.94 | 16 | 443200 | 625 | 70484603 |
| Head injury | 10.16 | 9.94 | 151 | 443065 | 33990 | 70451238 |
| Renal tubular disorder | 10.14 | 9.94 | 14 | 443202 | 6096 | 70479132 |
| Angina unstable | 10.12 | 9.94 | 58 | 443158 | 15835 | 70469393 |
| Hyperhomocysteinaemia | 10.11 | 9.94 | 13 | 443203 | 420 | 70484808 |
| Osteonecrosis | 10.11 | 9.94 | 125 | 443091 | 29035 | 70456193 |
| Hereditary angioedema | 10.10 | 9.94 | 10 | 443206 | 5049 | 70480179 |
| Lower limb fracture | 10.08 | 9.94 | 154 | 443062 | 16618 | 70468610 |
| Decreased insulin requirement | 10.04 | 9.94 | 8 | 443208 | 143 | 70485085 |
| Jaundice cholestatic | 10.03 | 9.94 | 27 | 443189 | 9157 | 70476071 |
| Mood altered | 10.03 | 9.94 | 61 | 443155 | 16414 | 70468814 |
| Mean cell volume increased | 10.01 | 9.94 | 65 | 443151 | 5579 | 70479649 |
| Vascular insufficiency | 9.99 | 9.94 | 14 | 443202 | 492 | 70484736 |
| Device breakage | 9.99 | 9.94 | 28 | 443188 | 9370 | 70475858 |
| Genital haemorrhage | 9.98 | 9.94 | 13 | 443203 | 5802 | 70479426 |
| Vascular rupture | 9.94 | 9.94 | 26 | 443190 | 1470 | 70483758 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003358 | Cosmetics |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D011837 | Radiation-Protective Agents |
| MeSH PA | D013473 | Sunscreening Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Proctitis | indication | 3951002 | DOID:3127 |
| Tinea pedis | indication | 6020002 | DOID:12403 |
| Wound | indication | 13924000 | |
| Burn injury | indication | 48333001 | |
| Candidiasis of skin | indication | 49883006 | |
| Pityriasis versicolor | indication | 56454009 | DOID:9060 |
| Hemorrhoids | indication | 70153002 | DOID:9746 |
| Rectal pain | indication | 77880009 | |
| Tinea corporis | indication | 84849002 | |
| Pruritus ani | indication | 90446007 | |
| Diaper rash | indication | 91487003 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Skin irritation | indication | 367466007 | |
| Tinea cruris | indication | 399029005 | |
| Arthropod bite wound | indication | 409985002 | |
| Itching of skin | indication | 418363000 | |
| Minor Bacterial Skin Infections | indication | ||
| Paronychia | off-label use | 71906005 | DOID:13117 |
| Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Anxiety | contraindication | 48694002 | |
| Wilson's disease | contraindication | 88518009 | |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Open wound | contraindication | 125643001 | |
| Hb SS disease | contraindication | 127040003 | DOID:10923 |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Hemochromatosis | contraindication | 399187006 | DOID:2352 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Denuded skin | contraindication | 418242004 | |
| Nervousness | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 0.25%;81.35%;15% | VUSION | MYLAN | N021026 | Feb. 16, 2006 | RX | OINTMENT | TOPICAL | 8147852 | March 30, 2028 | USE FOR TREATMENT OF DIAPER DERMATITIS COMPLICATED BY CANDIDIASIS |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| SOI2LOH54Z | UNII |
| 4019034 | VUID |
| N0000147305 | NUI |
| D01170 | KEGG_DRUG |
| 4017643 | VANDF |
| 4019034 | VANDF |
| 4019036 | VANDF |
| C0043491 | UMLSCUI |
| CHEBI:36560 | CHEBI |
| CHEMBL3988900 | ChEMBL_ID |
| DB09321 | DRUGBANK_ID |
| D015034 | MESH_DESCRIPTOR_UI |
| 11423 | RXNORM |
| 5049 | MMSL |
| 5709 | MMSL |
| 001922 | NDDF |
| 398971002 | SNOMEDCT_US |
| 42841002 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen | HUMAN OTC DRUG LABEL | 3 | 0023-5494 | LOTION | 80 mg | TOPICAL | OTC monograph not final | 12 sections |
| TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) | HUMAN OTC DRUG LABEL | 4 | 0023-5497 | LOTION | 80 mg | TOPICAL | OTC monograph not final | 12 sections |
| TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen | HUMAN OTC DRUG LABEL | 4 | 0023-5501 | LOTION | 10 mg | TOPICAL | OTC monograph not final | 8 sections |
| Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0023-5675 | LOTION | 60 mg | TOPICAL | OTC monograph not final | 8 sections |
| Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0023-5703 | LOTION | 60 mg | TOPICAL | OTC monograph not final | 7 sections |
| Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0023-5738 | LOTION | 120 mg | TOPICAL | OTC monograph not final | 8 sections |
| Solbar Shield SPF40 | HUMAN OTC DRUG LABEL | 2 | 0096-0682 | CREAM | 0.08 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Shield SPF40 | HUMAN OTC DRUG LABEL | 2 | 0096-0682 | CREAM | 0.08 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Zinc SPF38 | HUMAN OTC DRUG LABEL | 3 | 0096-0688 | CREAM | 0.08 1 | TOPICAL | OTC monograph final | 8 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0194 | PASTE | 40 g | TOPICAL | OTC monograph final | 11 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0323 | CREAM | 40 g | TOPICAL | OTC MONOGRAPH FINAL | 12 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0324 | OINTMENT | 16 g | TOPICAL | OTC MONOGRAPH FINAL | 12 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0333 | CREAM | 16 g | TOPICAL | OTC monograph final | 11 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0334 | CREAM | 16 g | TOPICAL | OTC monograph final | 11 sections |
| Boudreauxs | HUMAN OTC DRUG LABEL | 1 | 0132-0557 | CREAM | 16 g | TOPICAL | export only | 11 sections |
| Selan Plus Zinc Oxide | HUMAN OTC DRUG LABEL | 2 | 0159-2200 | CREAM | 2 g | TOPICAL | OTC monograph final | 11 sections |
| CALENDULA DIAPER RASH CREAM | HUMAN OTC DRUG LABEL | 1 | 0164-2189 | CREAM | 12 g | TOPICAL | OTC monograph final | 8 sections |
| WHITE MALLOW DIAPER RASH CREAM | HUMAN OTC DRUG LABEL | 1 | 0164-2207 | CREAM | 14 g | TOPICAL | OTC monograph final | 8 sections |
| ZINC OXIDE | HUMAN OTC DRUG LABEL | 1 | 0168-0062 | OINTMENT | 200 mg | TOPICAL | OTC monograph final | 9 sections |
| Dr. Smiths Rash and Skin | HUMAN OTC DRUG LABEL | 1 | 0178-0370 | OINTMENT | 10 g | TOPICAL | OTC monograph not final | 12 sections |
| CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 25 mg | ORAL | unapproved drug other | 11 sections |
| CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 25 mg | ORAL | unapproved drug other | 11 sections |
| CitraNatal 90 DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0829 | TABLET | 25 mg | ORAL | Unapproved drug other | 11 sections |
| CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0178-0858 | TABLET | 25 mg | ORAL | Unapproved drug other | 12 sections |
| CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 14 | 0178-0859 | TABLET | 25 mg | ORAL | Unapproved drug other | 9 sections |
| CitraNatal DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0898 | TABLET | 25 mg | ORAL | Unapproved drug other | 11 sections |
| Caladryl | HUMAN OTC DRUG LABEL | 3 | 0187-5465 | LOTION | 78.65 mg | TOPICAL | OTC monograph final | 14 sections |
| Calcemin Advance | HUMAN OTC DRUG LABEL | 5 | 0280-0272 | TABLET, FILM COATED | 7.50 mg | ORAL | Export only | 2 sections |
| Calcemin Silver | HUMAN OTC DRUG LABEL | 3 | 0280-0273 | TABLET, FILM COATED | 7.50 mg | ORAL | Export only | 2 sections |
| Cetaphil Sheer Mineral Sunscreen Stick SPF 50 | HUMAN OTC DRUG LABEL | 2 | 0299-4108 | STICK | 47 mg | TOPICAL | OTC monograph final | 11 sections |