zinc oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4240 1314-13-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zinc oxide
A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
  • Molecular weight: 81.38
  • Formula: OZn
  • CLOGP: -1.12
  • LIPINSKI: None
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 16, 2006 FDA DELCOR ASSET

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1615.50 10.13 3081 376163 117085 50108795
Systemic lupus erythematosus 1503.37 10.13 3279 375965 137343 50088537
Glossodynia 1295.72 10.13 2748 376496 112821 50113059
Rheumatoid arthritis 1060.52 10.13 3632 375612 198918 50026962
Hand deformity 1030.90 10.13 2302 376942 97897 50127983
Arthropathy 952.42 10.13 2972 376272 154934 50070946
Maternal exposure during pregnancy 925.88 10.13 2966 376278 156812 50069068
Alopecia 903.79 10.13 3932 375312 241115 49984765
Abdominal discomfort 883.46 10.13 3755 375489 227886 49997994
Wound 842.81 10.13 2202 377042 103592 50122288
Completed suicide 750.35 10.13 64 379180 131825 50094055
Infusion related reaction 674.08 10.13 2785 376459 166772 50059108
Synovitis 669.99 10.13 2247 376997 121618 50104262
Pericarditis 641.98 10.13 1653 377591 77036 50148844
Anti-cyclic citrullinated peptide antibody positive 630.58 10.13 1535 377709 69052 50156828
Contraindicated product administered 617.57 10.13 2479 376765 146479 50079401
Discomfort 601.95 10.13 1984 377260 106396 50119484
Joint swelling 579.00 10.13 3474 375770 241812 49984068
Swelling 578.44 10.13 3002 376242 197870 50028010
Pain 553.28 10.13 6690 372554 572213 49653667
Toxicity to various agents 550.62 10.13 470 378774 212029 50013851
Death 453.27 10.13 1115 378129 324264 49901616
Product use issue 390.51 10.13 2176 377068 147299 50078581
Rheumatoid factor positive 385.59 10.13 1027 378217 48832 50177048
Arthralgia 370.23 10.13 4958 374286 433744 49792136
Duodenal ulcer perforation 363.38 10.13 950 378294 44661 50181219
Helicobacter infection 351.72 10.13 991 378253 48711 50177169
Drug abuse 321.92 10.13 36 379208 59810 50166070
Hepatic enzyme increased 319.76 10.13 1940 377304 135440 50090440
Drug interaction 314.41 10.13 639 378605 198982 50026898
Intentional overdose 311.30 10.13 48 379196 62456 50163424
Exposure during pregnancy 280.35 10.13 1707 377537 119308 50106572
Musculoskeletal stiffness 259.24 10.13 1750 377494 126731 50099149
Drug intolerance 253.15 10.13 2632 376612 216472 50009408
Treatment failure 245.78 10.13 1820 377424 135817 50090063
Hip arthroplasty 243.56 10.13 635 378609 29794 50196086
Therapeutic product effect decreased 235.00 10.13 1785 377459 134265 50091615
Knee arthroplasty 225.07 10.13 685 378559 35161 50190719
Overdose 207.92 10.13 265 378979 99462 50126418
Febrile neutropenia 204.16 10.13 259 378985 97408 50128472
Suicide attempt 198.00 10.13 70 379174 51662 50174218
Psoriatic arthropathy 189.91 10.13 777 378467 46255 50179625
Nasopharyngitis 188.64 10.13 2243 377001 190684 50035196
Acute kidney injury 187.56 10.13 975 378269 227083 49998797
Cardiac arrest 187.45 10.13 210 379034 83441 50142439
C-reactive protein abnormal 183.63 10.13 541 378703 27268 50198612
Depressed level of consciousness 175.11 10.13 85 379159 51868 50174012
Red blood cell sedimentation rate abnormal 166.07 10.13 374 378870 15969 50209911
Hypersensitivity 161.05 10.13 2383 376861 212778 50013102
Diarrhoea 158.08 10.13 3289 375955 585187 49640693
Drug ineffective 157.61 10.13 7570 371674 811763 49414117
Malignant neoplasm progression 154.85 10.13 169 379075 67955 50157925
Disease progression 153.21 10.13 304 378940 95562 50130318
Device expulsion 146.10 10.13 21 379223 28801 50197079
Nausea 145.74 10.13 4102 375142 701296 49524584
Impaired healing 144.50 10.13 957 378287 68829 50157051
Constipation 141.05 10.13 815 378429 184893 50040987
Rheumatic fever 140.13 10.13 357 378887 16510 50209370
Swollen joint count increased 134.32 10.13 325 378919 14548 50211332
Bradycardia 133.42 10.13 172 379072 64254 50161626
Sickle cell anaemia with crisis 131.06 10.13 166 379078 4377 50221503
Lactic acidosis 129.59 10.13 44 379200 33311 50192569
Neutropenia 126.42 10.13 624 378620 147341 50078539
Cardiac failure 124.20 10.13 238 379006 75802 50150078
Drug hypersensitivity 122.80 10.13 1245 377999 249765 49976115
Asthenia 122.70 10.13 1669 377575 317373 49908507
Anxiety 119.57 10.13 809 378435 176797 50049083
Tremor 118.64 10.13 451 378793 114452 50111428
Hyponatraemia 117.97 10.13 350 378894 95789 50130091
Sedation 117.85 10.13 41 379203 30569 50195311
Electrocardiogram QT prolonged 115.41 10.13 131 379113 51755 50174125
Somnolence 111.93 10.13 691 378553 154294 50071586
Hypotension 110.63 10.13 1179 378065 234290 49991590
Dizziness 109.94 10.13 1880 377364 344489 49881391
Dyspnoea 109.62 10.13 3197 376047 544411 49681469
Pregnancy 108.78 10.13 475 378769 29102 50196778
Respiratory arrest 105.93 10.13 46 379198 29963 50195917
Agitation 104.98 10.13 148 379096 53236 50172644
Vomiting 104.05 10.13 2644 376600 458114 49767766
Renal failure 102.82 10.13 430 378814 106203 50119677
Rash 102.12 10.13 4126 375118 433345 49792535
Sleep disorder due to general medical condition, insomnia type 100.06 10.13 484 378760 30963 50194917
Psoriasis 98.85 10.13 868 378376 68132 50157748
Fatigue 98.65 10.13 6350 372894 701251 49524629
Muscle injury 98.51 10.13 543 378701 36568 50189312
Folliculitis 98.22 10.13 565 378679 38660 50187220
Live birth 96.90 10.13 307 378937 16101 50209779
Arthritis 96.72 10.13 1035 378209 85686 50140194
Multiple sclerosis relapse 96.07 10.13 108 379136 42856 50183024
Lower respiratory tract infection 93.84 10.13 1109 378135 94092 50131788
Abortion spontaneous 92.67 10.13 583 378661 41189 50184691
Sopor 90.87 10.13 19 379225 19860 50206020
Rhabdomyolysis 90.70 10.13 95 379149 38932 50186948
Intentional self-injury 90.63 10.13 30 379214 23082 50202798
Drug reaction with eosinophilia and systemic symptoms 90.58 10.13 50 379194 28374 50197506
Blister 89.53 10.13 1007 378237 84411 50141469
Hyperhidrosis 87.84 10.13 358 378886 89068 50136812
Neoplasm progression 87.67 10.13 55 379189 29102 50196778
Condition aggravated 87.06 10.13 2875 376369 294183 49931697
Osteoarthritis 85.17 10.13 837 378407 67769 50158111
Insomnia 81.89 10.13 876 378368 173989 50051891
Neuropathy peripheral 81.48 10.13 410 378834 96347 50129533
Cardio-respiratory arrest 80.93 10.13 177 379067 53715 50172165
Drug withdrawal syndrome 80.10 10.13 44 379200 25037 50200843
Injection site erythema 79.24 10.13 885 378359 74051 50151829
Blood pressure fluctuation 75.17 10.13 493 378751 35330 50190550
Myalgia 75.06 10.13 584 378660 123735 50102145
Tachycardia 74.50 10.13 440 378804 99323 50126557
Renal impairment 74.23 10.13 303 378941 75358 50150522
Product quality issue 74.12 10.13 73 379171 30785 50195095
Serotonin syndrome 73.78 10.13 47 379197 24666 50201214
Syncope 72.38 10.13 463 378781 102539 50123341
Drug dependence 71.81 10.13 29 379215 19730 50206150
Hypoglycaemia 71.70 10.13 187 379057 53394 50172486
Irritable bowel syndrome 71.54 10.13 643 378601 50798 50175082
Cognitive disorder 70.39 10.13 140 379104 43983 50181897
Joint effusion 69.15 10.13 235 379009 12786 50213094
Palmar-plantar erythrodysaesthesia syndrome 69.07 10.13 32 379212 20066 50205814
Encephalopathy 68.75 10.13 91 379153 33620 50192260
Hepatic failure 68.06 10.13 85 379159 32198 50193682
Coma 66.95 10.13 211 379033 56668 50169212
Injection site pruritus 66.75 10.13 525 378719 39886 50185994
Anaemia 66.22 10.13 1415 377829 251041 49974839
Hypoxia 65.71 10.13 182 379062 50941 50174939
Drug resistance 64.08 10.13 31 379213 18958 50206922
Hyperglycaemia 63.86 10.13 109 379135 36296 50189584
Basal cell carcinoma 63.50 10.13 344 378900 23012 50202868
Intentional product misuse 63.38 10.13 162 379082 46572 50179308
Disability assessment scale score increased 63.07 10.13 83 379161 2275 50223605
Juvenile idiopathic arthritis 63.00 10.13 92 379152 2787 50223093
Metabolic acidosis 62.96 10.13 122 379122 38703 50187177
Caesarean section 62.81 10.13 258 378986 15381 50210499
No adverse event 62.20 10.13 97 379147 33481 50192399
Sinusitis 61.81 10.13 1695 377549 168863 50057017
Asthma 61.03 10.13 405 378839 88932 50136948
Muscle spasms 60.77 10.13 624 378620 124929 50100951
Feeling abnormal 59.80 10.13 626 378618 124866 50101014
Red blood cell sedimentation rate increased 59.41 10.13 401 378843 29015 50196865
Thrombocytopenia 58.37 10.13 643 378601 127030 50098850
Cardiac failure congestive 57.91 10.13 382 378862 84000 50141880
Urticaria 57.46 10.13 657 378587 128904 50096976
Balance disorder 57.23 10.13 303 378941 70287 50155593
Respiratory failure 56.59 10.13 425 378819 90756 50135124
Foot deformity 56.39 10.13 289 378955 18921 50206959
Blood glucose increased 56.24 10.13 309 378935 71015 50154865
Contusion 56.23 10.13 1166 378078 111017 50114863
Joint laxity 55.95 10.13 79 379165 2319 50223561
Multiple organ dysfunction syndrome 55.61 10.13 192 379052 50145 50175735
Ill-defined disorder 54.86 10.13 639 378605 54015 50171865
Fluid retention 54.74 10.13 195 379049 50454 50175426
Cholestasis 54.47 10.13 66 379178 25335 50200545
Hallucination 54.26 10.13 174 379070 46483 50179397
Muscle spasticity 53.65 10.13 31 379213 17153 50208727
Hepatic function abnormal 52.73 10.13 103 379141 32578 50193302
Osteoporosis 52.54 10.13 541 378703 44338 50181542
Altered state of consciousness 52.42 10.13 52 379192 21858 50204022
Blood pressure diastolic abnormal 52.42 10.13 172 379072 9189 50216691
Seizure 52.17 10.13 598 378646 117276 50108604
Injection site swelling 52.00 10.13 510 378734 41263 50184617
Diabetic ketoacidosis 51.98 10.13 35 379209 17837 50208043
Disturbance in attention 51.44 10.13 97 379147 31089 50194791
Joint stiffness 51.30 10.13 396 378848 29912 50195968
Injection site reaction 51.12 10.13 587 378657 49445 50176435
Pulmonary embolism 50.65 10.13 502 378742 101202 50124678
Peripheral swelling 50.34 10.13 1953 377291 203983 50021897
Infection 50.32 10.13 1673 377571 171281 50054599
Chest discomfort 50.31 10.13 448 378796 92274 50133606
Injection site pain 50.21 10.13 1137 378107 109887 50115993
Emotional distress 50.10 10.13 86 379158 28577 50197303
Vision blurred 50.04 10.13 364 378880 78283 50147597
Cytomegalovirus infection 49.84 10.13 37 379207 17925 50207955
Fibromyalgia 49.74 10.13 536 378708 44442 50181438
Blood cholesterol increased 49.52 10.13 632 378612 54583 50171297
Restlessness 49.27 10.13 70 379174 25103 50200777
Type 2 diabetes mellitus 48.98 10.13 432 378812 33943 50191937
Hepatocellular injury 48.98 10.13 74 379170 25873 50200007
Foetal exposure during pregnancy 48.85 10.13 362 378882 26997 50198883
Respiratory disorder 48.85 10.13 100 379144 31087 50194793
Metastases to bone 48.74 10.13 38 379206 17957 50207923
Dehydration 48.69 10.13 826 378418 151623 50074257
Premature labour 48.22 10.13 192 379052 11284 50214596
Blood pressure systolic increased 48.21 10.13 441 378803 35008 50190872
Grip strength decreased 47.92 10.13 199 379045 11922 50213958
Sedation complication 47.82 10.13 5 379239 8761 50217119
Product use in unapproved indication 47.27 10.13 598 378646 115221 50110659
Bone erosion 47.09 10.13 193 379051 11494 50214386
Depression 46.96 10.13 915 378329 164508 50061372
Mydriasis 46.87 10.13 11 379233 10616 50215264
Mental status changes 46.70 10.13 129 379115 36143 50189737
Orthostatic hypotension 46.63 10.13 94 379150 29387 50196493
Hypokalaemia 46.50 10.13 428 378816 87564 50138316
Decreased appetite 46.23 10.13 1149 378095 199774 50026106
Dyspnoea exertional 46.08 10.13 212 379032 51021 50174859
Poisoning 45.56 10.13 18 379226 12411 50213469
Loss of personal independence in daily activities 45.49 10.13 758 378486 69292 50156588
Hyperkalaemia 45.05 10.13 196 379048 47893 50177987
Loss of consciousness 44.78 10.13 533 378711 103820 50122060
Delirium 44.71 10.13 142 379102 38050 50187830
Blood pressure systolic abnormal 44.42 10.13 143 379101 7563 50218317
Gestational diabetes 44.37 10.13 140 379104 7325 50218555
White blood cell count decreased 43.51 10.13 614 378630 116108 50109772
Neutrophil count decreased 43.47 10.13 187 379057 45839 50180041
Hospitalisation 43.42 10.13 314 378930 67623 50158257
Pulmonary arterial hypertension 43.35 10.13 53 379191 20266 50205614
Ejection fraction decreased 43.12 10.13 45 379199 18475 50207405
Neck deformity 42.98 10.13 63 379181 1915 50223965
Memory impairment 42.81 10.13 384 378860 78976 50146904
Speech disorder 42.44 10.13 131 379113 35417 50190463
Multiple fractures 42.10 10.13 127 379117 6484 50219396
Suicidal ideation 42.01 10.13 243 379001 55142 50170738
Musculoskeletal pain 41.84 10.13 767 378477 71410 50154470
Maternal drugs affecting foetus 41.69 10.13 107 379137 4970 50220910
Anaphylactic reaction 41.63 10.13 236 379008 53819 50172061
Extrapyramidal disorder 41.61 10.13 18 379226 11752 50214128
Disorientation 41.49 10.13 132 379112 35352 50190528
Product administration error 41.38 10.13 52 379192 19647 50206233
Acute hepatic failure 41.34 10.13 34 379210 15643 50210237
Myocardial infarction 41.22 10.13 447 378797 88580 50137300
Tuberculosis 41.01 10.13 167 379077 9916 50215964
Osteonecrosis of jaw 40.90 10.13 117 379127 32409 50193471
Shock 40.84 10.13 57 379187 20593 50205287
Leukopenia 40.83 10.13 317 378927 67211 50158669
Blood pressure decreased 40.45 10.13 249 378995 55660 50170220
Rheumatoid nodule 39.78 10.13 195 379049 12540 50213340
Localised infection 39.32 10.13 326 378918 25159 50200721
Weight increased 38.68 10.13 1867 377377 200024 50025856
Posterior reversible encephalopathy syndrome 38.59 10.13 33 379211 14895 50210985
Unresponsive to stimuli 38.57 10.13 110 379134 30499 50195381
Respiratory depression 38.45 10.13 21 379223 11989 50213891
Drug level increased 38.29 10.13 53 379191 19215 50206665
Pre-eclampsia 38.25 10.13 140 379104 7904 50217976
Abnormal behaviour 38.14 10.13 55 379189 19603 50206277
Angioedema 38.13 10.13 149 379095 37527 50188353
Creatinine renal clearance decreased 37.71 10.13 21 379223 11860 50214020
Blood creatine phosphokinase increased 37.63 10.13 89 379155 26278 50199602
Hypothermia 37.05 10.13 22 379222 11994 50213886
Gamma-glutamyltransferase increased 36.92 10.13 107 379137 29516 50196364
Cerebral haemorrhage 36.50 10.13 94 379150 26958 50198922
Deep vein thrombosis 35.99 10.13 363 378881 72941 50152939
Blood pressure diastolic decreased 35.84 10.13 232 379012 16549 50209331
Pain in jaw 35.76 10.13 157 379087 38271 50187609
Enthesopathy 35.75 10.13 127 379117 7066 50218814
Platelet count decreased 35.74 10.13 535 378709 100191 50125689
Palpitations 35.62 10.13 496 378748 94010 50131870
Dysgeusia 35.61 10.13 160 379084 38756 50187124
Vertigo 35.37 10.13 235 379009 51597 50174283
Dysarthria 35.30 10.13 152 379092 37251 50188629
Infective pulmonary exacerbation of cystic fibrosis 35.25 10.13 8 379236 7901 50217979
Polyarthritis 35.23 10.13 135 379109 7792 50218088
Disseminated intravascular coagulation 35.20 10.13 46 379198 17089 50208791
Inflammation 35.19 10.13 611 378633 56301 50169579
Blood alkaline phosphatase increased 35.11 10.13 153 379091 37373 50188507
Ventricular septal defect 35.10 10.13 87 379157 3954 50221926
Ascites 34.92 10.13 144 379100 35717 50190163
Torsade de pointes 34.66 10.13 23 379221 11812 50214068
Metastases to liver 34.52 10.13 61 379183 20043 50205837
Maternal exposure before pregnancy 34.22 10.13 106 379138 5491 50220389
Blood bilirubin increased 34.18 10.13 124 379120 31914 50193966
Nodule 33.86 10.13 231 379013 16772 50209108
Bone pain 33.82 10.13 211 379033 47018 50178862
Joint injury 33.76 10.13 279 378965 21510 50204370
Brain oedema 33.66 10.13 26 379218 12344 50213536
Drug ineffective for unapproved indication 33.53 10.13 68 379176 21213 50204667
Pulmonary fibrosis 33.22 10.13 304 378940 24133 50201747
Haemorrhage 33.19 10.13 249 378995 53192 50172688
Limb deformity 33.08 10.13 81 379163 3653 50222227
Intentional product use issue 32.99 10.13 782 378462 76136 50149744
Device dislocation 32.97 10.13 70 379174 21476 50204404
Injection site rash 32.95 10.13 221 379023 15956 50209924
Arrhythmia 32.91 10.13 132 379112 33000 50192880
Flushing 32.84 10.13 332 378912 66683 50159197
Dysphagia 32.84 10.13 397 378847 77121 50148759
Joint destruction 32.64 10.13 83 379161 3833 50222047
Injection site bruising 32.60 10.13 420 378824 36348 50189532
Aspartate aminotransferase increased 32.46 10.13 401 378843 77597 50148283
Tenderness 32.21 10.13 244 379000 18321 50207559
Chest pain 32.15 10.13 1045 378199 175837 50050043
Premature delivery 31.98 10.13 294 378950 23369 50202511
Wrong technique in product usage process 31.98 10.13 264 378980 55246 50170634
Disability 31.96 10.13 184 379060 12591 50213289
Akathisia 31.71 10.13 11 379233 8218 50217662
C-reactive protein increased 31.69 10.13 686 378558 65788 50160092
Ventricular fibrillation 31.63 10.13 20 379224 10539 50215341
Femur fracture 31.57 10.13 424 378820 37040 50188840
Chronic kidney disease 31.51 10.13 172 379072 39599 50186281
Accidental overdose 31.13 10.13 62 379182 19471 50206409
Premature rupture of membranes 31.09 10.13 90 379154 4490 50221390
Small for dates baby 31.01 10.13 76 379168 3429 50222451
Ventricular tachycardia 30.96 10.13 44 379200 15777 50210103
Neuroleptic malignant syndrome 30.79 10.13 23 379221 11107 50214773
Inappropriate antidiuretic hormone secretion 30.53 10.13 32 379212 13111 50212769
Blood calcium decreased 30.26 10.13 69 379175 20637 50205243
Alanine aminotransferase increased 30.09 10.13 473 378771 87886 50137994
Psychotic disorder 30.04 10.13 75 379169 21737 50204143
Tenosynovitis stenosans 29.76 10.13 57 379187 2167 50223713
Withdrawal syndrome 29.64 10.13 54 379190 17536 50208344
Diabetes mellitus inadequate control 29.43 10.13 33 379211 13112 50212768
Nightmare 29.29 10.13 47 379197 16039 50209841
Cytokine release syndrome 29.28 10.13 14 379230 8620 50217260
Cerebrovascular accident 29.24 10.13 516 378728 94164 50131716
Pleural effusion 29.11 10.13 432 378812 81022 50144858
Heart rate decreased 29.10 10.13 409 378835 36088 50189792
Dyskinesia 28.31 10.13 110 379134 27751 50198129
Schizophrenia 28.31 10.13 10 379234 7387 50218493
Atrial fibrillation 28.18 10.13 565 378679 101180 50124700
Smear cervix abnormal 28.15 10.13 63 379181 2678 50223202
Joint range of motion decreased 28.13 10.13 236 379008 18276 50207604
Pulmonary oedema 28.08 10.13 233 379011 48705 50177175
Immune reconstitution inflammatory syndrome 28.00 10.13 4 379240 5512 50220368
Anaphylactic shock 27.99 10.13 69 379175 20086 50205794
Hypomagnesaemia 27.88 10.13 85 379159 23071 50202809
Skin ulcer 27.85 10.13 395 378849 34923 50190957
Blood pressure diastolic increased 27.72 10.13 120 379124 7323 50218557
Coagulopathy 27.71 10.13 58 379186 17886 50207994
Synovial cyst 27.66 10.13 128 379116 8038 50217842
Respiratory distress 27.51 10.13 126 379118 30363 50195517
Pain in extremity 27.30 10.13 2387 376857 270478 49955402
Latent tuberculosis 27.01 10.13 55 379189 2188 50223692
Tenosynovitis 26.97 10.13 153 379091 10412 50215468
Neurotoxicity 26.90 10.13 43 379201 14697 50211183
Crying 26.74 10.13 72 379172 20344 50205536
Device difficult to use 26.62 10.13 21 379223 9865 50216015
Polyneuropathy 26.56 10.13 31 379213 12100 50213780
Acute respiratory failure 26.53 10.13 118 379126 28664 50197216
Back pain 26.47 10.13 1363 377881 218667 50007213
Obstructive airways disorder 26.42 10.13 48 379196 15604 50210276
Laryngitis 26.24 10.13 156 379088 10800 50215080
Melaena 26.08 10.13 108 379136 26756 50199124
Dysmorphism 25.93 10.13 53 379191 2114 50223766
Irritability 25.93 10.13 117 379127 28309 50197571
Bradyphrenia 25.91 10.13 7 379237 6145 50219735
Gastrointestinal haemorrhage 25.81 10.13 390 378854 72931 50152949
Atrioventricular block complete 25.80 10.13 11 379233 7244 50218636
Eosinophilia 25.79 10.13 64 379180 18588 50207292
Wheelchair user 25.76 10.13 89 379155 4883 50220997
Arthritis infective 25.71 10.13 96 379148 5473 50220407
Pulmonary hypertension 25.67 10.13 146 379098 33271 50192609
Blood creatinine increased 25.49 10.13 409 378835 75751 50150129
Asphyxia 25.19 10.13 5 379239 5422 50220458
Ischaemic stroke 25.09 10.13 51 379193 15897 50209983
Developmental hip dysplasia 25.04 10.13 39 379205 1252 50224628
Drug tolerance decreased 24.95 10.13 135 379109 9025 50216855
Skin papilloma 24.85 10.13 79 379165 4150 50221730
Bronchospasm 24.67 10.13 46 379198 14808 50211072
Jaundice 24.58 10.13 108 379136 26321 50199559
Metastases to central nervous system 24.52 10.13 29 379215 11253 50214627
Aggression 24.37 10.13 79 379165 21037 50204843
Malignant melanoma 24.26 10.13 144 379100 9964 50215916
Device use error 24.14 10.13 5 379239 5261 50220619
Acute generalised exanthematous pustulosis 24.05 10.13 19 379225 8919 50216961
Transplant rejection 23.93 10.13 22 379222 9587 50216293
Paralysis 23.84 10.13 18 379226 8646 50217234
Product dose omission issue 23.82 10.13 1130 378114 182708 50043172
Mania 23.79 10.13 28 379216 10888 50214992
Second primary malignancy 23.77 10.13 11 379233 6903 50218977
Oedema peripheral 23.76 10.13 955 378289 157006 50068874
Neck mass 23.74 10.13 67 379177 3294 50222586
Polyhydramnios 23.61 10.13 49 379195 1976 50223904
Haematotoxicity 23.59 10.13 15 379229 7880 50218000
Parkinsonism 23.56 10.13 19 379225 8828 50217052
Stress cardiomyopathy 23.54 10.13 15 379229 7872 50218008
Hypomania 23.50 10.13 3 379241 4502 50221378
Placental disorder 23.40 10.13 40 379204 1390 50224490
Febrile bone marrow aplasia 23.37 10.13 9 379235 6302 50219578
Fear 23.34 10.13 46 379198 14503 50211377
Toxic skin eruption 23.32 10.13 30 379214 11221 50214659
Thrombotic microangiopathy 23.26 10.13 19 379225 8772 50217108
Hypervolaemia 23.23 10.13 105 379139 25394 50200486
Synovial fluid analysis 23.18 10.13 43 379201 1595 50224285
Abdominal pain 23.06 10.13 1493 377751 234735 49991145
Myoclonus 23.00 10.13 46 379198 14424 50211456
Pancreatitis acute 22.94 10.13 96 379148 23716 50202164
Spinal stenosis 22.90 10.13 177 379067 13373 50212507
Depressed mood 22.84 10.13 155 379089 33868 50192012
Abdominal distension 22.61 10.13 397 378847 72506 50153374
Panic attack 22.58 10.13 72 379172 19270 50206610
Graft versus host disease 22.49 10.13 9 379235 6157 50219723
Hemiparesis 22.46 10.13 76 379168 19972 50205908
Pancreatitis 22.19 10.13 208 379036 42406 50183474
Oropharyngeal pain 21.94 10.13 750 378494 77051 50148829
Unevaluable event 21.84 10.13 230 379014 45836 50180044
Rotator cuff repair 21.77 10.13 43 379201 1673 50224207
Headache 21.74 10.13 3399 375845 503136 49722744
Complication of device insertion 21.74 10.13 9 379235 6032 50219848
Agranulocytosis 21.49 10.13 85 379159 21336 50204544
Loose body in joint 21.49 10.13 35 379209 1168 50224712
Muscular weakness 21.37 10.13 545 378699 94468 50131412
Stomatitis 21.27 10.13 946 378298 100398 50125482
Anhedonia 21.22 10.13 24 379220 9500 50216380
Blood potassium decreased 21.15 10.13 176 379068 36769 50189111
Substance abuse 20.91 10.13 3 379241 4121 50221759
Pulmonary tuberculosis 20.85 10.13 75 379169 4198 50221682
Cytopenia 20.79 10.13 21 379223 8754 50217126
Dystonia 20.64 10.13 36 379208 11890 50213990
Confusional state 20.63 10.13 1161 378083 184767 50041113
Lethargy 20.61 10.13 254 378990 49178 50176702
Postoperative wound infection 20.51 10.13 121 379123 8354 50217526
Product adhesion issue 20.49 10.13 4 379240 4388 50221492
Cardiogenic shock 20.44 10.13 55 379189 15544 50210336
Cardiac failure acute 20.41 10.13 19 379225 8231 50217649
Herpes zoster 20.37 10.13 684 378560 70102 50155778
Genital haemorrhage 20.32 10.13 12 379232 6562 50219318
Glycosylated haemoglobin increased 20.26 10.13 30 379214 10576 50215304
Metastases to lung 20.25 10.13 32 379212 10988 50214892
Miosis 20.25 10.13 11 379233 6299 50219581
Therapeutic response decreased 20.19 10.13 480 378764 46751 50179129
Tardive dyskinesia 20.19 10.13 15 379229 7264 50218616
COVID-19 20.13 10.13 238 379006 46424 50179456
Sepsis 20.12 10.13 803 378441 132122 50093758
Psychomotor hyperactivity 20.12 10.13 24 379220 9277 50216603
Nervousness 20.07 10.13 123 379121 27528 50198352
Haemorrhage intracranial 19.96 10.13 39 379205 12335 50213545
Disease recurrence 19.95 10.13 80 379164 20001 50205879
Plasma cell myeloma 19.90 10.13 145 379099 31177 50194703
Body temperature decreased 19.83 10.13 199 379045 16196 50209684
Hyperlipidaemia 19.80 10.13 66 379178 17424 50208456
Acute graft versus host disease 19.79 10.13 3 379241 3955 50221925
Atrial septal defect 19.74 10.13 97 379147 6244 50219636
Pyrexia 19.71 10.13 2522 376722 377681 49848199
Tumour lysis syndrome 19.68 10.13 16 379228 7405 50218475
Gastroenteritis viral 19.45 10.13 221 379023 18565 50207315
Uterine perforation 19.42 10.13 12 379232 6403 50219477
Status epilepticus 19.33 10.13 45 379199 13361 50212519
Post transplant lymphoproliferative disorder 19.25 10.13 4 379240 4200 50221680
Accidental exposure to product 19.22 10.13 98 379146 22959 50202921
Joint dislocation 19.15 10.13 158 379086 12175 50213705
Body height below normal 19.13 10.13 44 379200 1905 50223975
Acute myeloid leukaemia 19.11 10.13 54 379190 15020 50210860
Injection site warmth 19.10 10.13 173 379071 13693 50212187
Face oedema 19.06 10.13 69 379175 17770 50208110
International normalised ratio increased 19.04 10.13 219 379025 42933 50182947
Haemophagocytic lymphohistiocytosis 18.97 10.13 22 379222 8611 50217269
Acute chest syndrome 18.94 10.13 24 379220 633 50225247
Sinus tachycardia 18.82 10.13 89 379155 21265 50204615
Foetal death 18.65 10.13 115 379129 8065 50217815
Tachypnoea 18.65 10.13 52 379192 14525 50211355
Atrioventricular block 18.42 10.13 13 379231 6465 50219415
Red blood cell sedimentation rate 18.41 10.13 64 379180 3522 50222358
Infusion site erythema 18.37 10.13 23 379221 8704 50217176
Dementia 18.36 10.13 60 379184 15937 50209943
Foetal anticonvulsant syndrome 18.27 10.13 22 379222 550 50225330
Subdural haematoma 18.24 10.13 44 379200 12903 50212977
Complication associated with device 18.22 10.13 53 379191 14602 50211278
Cushingoid 18.15 10.13 98 379146 6547 50219333
Maternal exposure timing unspecified 18.06 10.13 64 379180 3556 50222324
Pemphigoid 17.95 10.13 11 379233 5896 50219984
Congenital arterial malformation 17.94 10.13 17 379227 320 50225560
Cholecystitis chronic 17.84 10.13 28 379216 9641 50216239
Stevens-Johnson syndrome 17.83 10.13 93 379151 21659 50204221
Exposure to toxic agent 17.78 10.13 3 379241 3655 50222225
Lupus-like syndrome 17.76 10.13 127 379117 9364 50216516
Salivary hypersecretion 17.75 10.13 14 379230 6577 50219303
Urinary retention 17.74 10.13 119 379125 26071 50199809
Off label use 17.72 10.13 3208 376036 471218 49754662
Paradoxical drug reaction 17.70 10.13 3 379241 3644 50222236
Clear cell renal cell carcinoma 17.55 10.13 32 379212 1171 50224709
Shock haemorrhagic 17.55 10.13 22 379222 8322 50217558
Joint noise 17.54 10.13 63 379181 3524 50222356
Mood altered 17.53 10.13 44 379200 12729 50213151
Antinuclear antibody positive 17.47 10.13 93 379151 6179 50219701
Hypertransaminasaemia 17.46 10.13 3 379241 3608 50222272
Crohn's disease 17.39 10.13 76 379168 4657 50221223
Device related infection 17.36 10.13 88 379156 20647 50205233
Infusion site pain 17.36 10.13 42 379202 12304 50213576
Fear of injection 17.34 10.13 91 379153 6012 50219868
Ketoacidosis 17.24 10.13 4 379240 3891 50221989
Haemorrhage in pregnancy 17.24 10.13 39 379205 1670 50224210
Proteinuria 17.20 10.13 65 379179 16532 50209348
Synovial disorder 17.20 10.13 27 379217 873 50225007
Dactylitis 17.16 10.13 41 379203 1820 50224060
Hallucination, auditory 17.14 10.13 34 379210 10694 50215186
Complication of device removal 17.05 10.13 5 379239 4159 50221721
Wheezing 17.04 10.13 345 378899 61702 50164178
Gestational hypertension 17.03 10.13 45 379199 2128 50223752
Breast feeding 16.99 10.13 26 379218 822 50225058
Incorrect route of product administration 16.92 10.13 77 379167 18589 50207291
Scleritis 16.92 10.13 58 379186 3169 50222711
Erythema multiforme 16.90 10.13 26 379218 9024 50216856
Hypophosphataemia 16.86 10.13 23 379221 8391 50217489
Oral herpes 16.82 10.13 233 379011 20492 50205388
Acidosis 16.70 10.13 32 379212 10195 50215685
Myocarditis 16.67 10.13 21 379223 7926 50217954
Aphasia 16.64 10.13 135 379109 28359 50197521
Dislocation of vertebra 16.64 10.13 56 379188 3031 50222849
Leukocytosis 16.62 10.13 100 379144 22479 50203401
Skin cancer 16.60 10.13 124 379120 9270 50216610
Dry skin 16.51 10.13 226 379018 42965 50182915
Stillbirth 16.40 10.13 88 379156 5864 50220016
Sleep apnoea syndrome 16.39 10.13 108 379136 23760 50202120
Myopathy 16.36 10.13 27 379217 9112 50216768
Muscle twitching 16.28 10.13 60 379184 15371 50210509
Cerebral infarction 16.26 10.13 95 379149 21509 50204371
Antibody test positive 16.26 10.13 46 379198 2265 50223615
Talipes 16.24 10.13 34 379210 1380 50224500
Respiration abnormal 16.22 10.13 9 379235 5093 50220787
Diabetes mellitus 16.18 10.13 264 378980 48769 50177111
Lymphocyte count decreased 16.13 10.13 123 379121 26184 50199696
Labelled drug-drug interaction medication error 16.06 10.13 34 379210 10443 50215437
Multiple sclerosis 16.03 10.13 89 379155 20404 50205476
Hallucination, visual 15.88 10.13 67 379177 16515 50209365
Hyperprolactinaemia 15.83 10.13 3 379241 3362 50222518
Fracture delayed union 15.71 10.13 45 379199 2231 50223649
Temperature regulation disorder 15.70 10.13 6 379238 4221 50221659
Oedema 15.66 10.13 403 378841 69778 50156102
Rash maculo-papular 15.66 10.13 126 379118 26515 50199365
Fracture 15.65 10.13 194 379050 16639 50209241
Cardiomyopathy 15.54 10.13 62 379182 15524 50210356
Haemoptysis 15.48 10.13 120 379124 25453 50200427
Haematoma 15.42 10.13 150 379094 30360 50195520
Pathogen resistance 15.42 10.13 12 379232 5677 50220203
Aspergillus infection 15.40 10.13 17 379227 6804 50219076
Product prescribing error 15.34 10.13 93 379151 20868 50205012
Malaise 15.20 10.13 2244 377000 333288 49892592
Immunodeficiency 15.15 10.13 174 379070 14654 50211226
Multiple allergies 15.15 10.13 25 379219 8438 50217442
Aspiration 15.11 10.13 29 379215 9235 50216645
Neonatal respiratory distress syndrome 15.07 10.13 49 379195 2605 50223275
Human antichimeric antibody positive 15.04 10.13 34 379210 1455 50224425
Infusion site swelling 15.01 10.13 19 379225 7157 50218723
Colitis microscopic 15.00 10.13 16 379228 6504 50219376
Injection site haematoma 14.97 10.13 87 379157 5973 50219907
Bronchopulmonary aspergillosis 14.97 10.13 21 379223 7571 50218309
Mouth ulceration 14.93 10.13 294 378950 27730 50198150
Tendonitis 14.88 10.13 191 379053 16514 50209366
Tubulointerstitial nephritis 14.86 10.13 61 379183 15150 50210730
Pharyngitis streptococcal 14.85 10.13 115 379129 8693 50217187
Abdominal pain upper 14.83 10.13 1011 378233 158298 50067582
Delusion 14.82 10.13 36 379208 10533 50215347
Poor venous access 14.75 10.13 130 379114 10210 50215670
Polyuria 14.75 10.13 19 379225 7102 50218778
Generalised oedema 14.74 10.13 53 379191 13678 50212202
Bone marrow failure 14.74 10.13 134 379110 27490 50198390
Therapy non-responder 14.67 10.13 493 378751 50529 50175351
Bundle branch block left 14.66 10.13 15 379229 6215 50219665
Device breakage 14.62 10.13 31 379213 9516 50216364
Rash erythematous 14.56 10.13 179 379065 34673 50191207
Bone disorder 14.49 10.13 209 379035 18543 50207337
Clostridium difficile colitis 14.46 10.13 76 379168 17666 50208214
Angina pectoris 14.43 10.13 126 379118 26062 50199818
Toxic epidermal necrolysis 14.41 10.13 95 379149 20897 50204983
Pulmonary congestion 14.36 10.13 62 379182 15185 50210695
Blood glucose decreased 14.29 10.13 79 379165 18132 50207748
Speech disorder developmental 14.22 10.13 20 379224 585 50225295
Muscle rigidity 14.17 10.13 33 379211 9796 50216084
Squamous cell carcinoma 14.16 10.13 103 379141 7636 50218244
Hypophagia 14.15 10.13 136 379108 27592 50198288
Exomphalos 14.08 10.13 19 379225 534 50225346
Anger 14.08 10.13 41 379203 11292 50214588
Oliguria 14.04 10.13 25 379219 8191 50217689
Affective disorder 13.96 10.13 11 379233 5170 50220710
Cholestasis of pregnancy 13.94 10.13 28 379216 1103 50224777
Pericardial effusion 13.71 10.13 124 379120 25465 50200415
Lip swelling 13.63 10.13 119 379125 24617 50201263
Blood iron increased 13.55 10.13 31 379213 1337 50224543
Cyanosis 13.55 10.13 63 379181 15121 50210759
Hot flush 13.54 10.13 241 379003 43928 50181952
Skin exfoliation 13.53 10.13 174 379070 33438 50192442
Paraesthesia 13.48 10.13 750 378494 119493 50106387
Joint lock 13.46 10.13 40 379204 2025 50223855
Coronary artery disease 13.45 10.13 150 379094 29576 50196304
Hallucinations, mixed 13.39 10.13 7 379237 4096 50221784
Tumour marker increased 13.37 10.13 6 379238 3834 50222046
Myelosuppression 13.33 10.13 54 379190 13463 50212417
Autism spectrum disorder 13.31 10.13 21 379223 682 50225198
Hypertelorism 13.26 10.13 16 379228 401 50225479
Gastrointestinal disorder 13.24 10.13 849 378395 93607 50132273
Foetal distress syndrome 13.22 10.13 29 379215 1216 50224664
Renal injury 13.16 10.13 28 379216 8583 50217297
Klebsiella infection 13.12 10.13 21 379223 7173 50218707
Immunosuppression 13.11 10.13 98 379146 7328 50218552
Wound infection 13.07 10.13 144 379100 12004 50213876
Right ventricular failure 13.00 10.13 68 379176 15825 50210055
Therapy change 12.97 10.13 12 379232 5213 50220667
Induced labour 12.94 10.13 24 379220 890 50224990
Purpura 12.94 10.13 35 379209 9876 50216004
Mental disorder 12.93 10.13 104 379140 21887 50203993
Surgery 12.92 10.13 307 378937 29898 50195982
Catheter site pain 12.91 10.13 6 379238 3756 50222124
Urinary incontinence 12.90 10.13 142 379102 28066 50197814
Visual acuity reduced 12.90 10.13 93 379151 20046 50205834
Cervical incompetence 12.83 10.13 19 379225 583 50225297
Sinus bradycardia 12.79 10.13 53 379191 13130 50212750
Tongue disorder 12.70 10.13 115 379129 9101 50216779
Occult blood 12.68 10.13 28 379216 1179 50224701
Influenza 12.59 10.13 805 378439 88733 50137147
Transplant dysfunction 12.55 10.13 10 379234 4674 50221206
Treatment noncompliance 12.54 10.13 155 379089 29995 50195885
Maternal exposure during breast feeding 12.53 10.13 53 379191 3201 50222679
Visual impairment 12.47 10.13 403 378841 67872 50158008
Pulseless electrical activity 12.44 10.13 20 379224 6821 50219059
Pneumonia viral 12.41 10.13 20 379224 6814 50219066
Pleuritic pain 12.37 10.13 87 379157 6379 50219501
Swollen tongue 12.36 10.13 146 379098 28484 50197396
Polydipsia 12.35 10.13 4 379240 3120 50222760
Bundle branch block right 12.34 10.13 10 379234 4635 50221245
Anuria 12.34 10.13 43 379201 11201 50214679
Ankylosing spondylitis 12.33 10.13 94 379150 7071 50218809
Drug abuser 12.33 10.13 3 379241 2825 50223055
Malignant mediastinal neoplasm 12.31 10.13 18 379226 546 50225334
Joint warmth 12.31 10.13 30 379214 1349 50224531
Lymphatic fistula 12.30 10.13 21 379223 729 50225151
Epstein-Barr virus infection 12.22 10.13 21 379223 6976 50218904
Colitis 12.20 10.13 209 379035 38320 50187560
Vascular device infection 12.20 10.13 9 379235 4375 50221505
Toxic encephalopathy 12.18 10.13 14 379230 5501 50220379
Product substitution issue 12.15 10.13 59 379185 13998 50211882
Arthritis bacterial 12.13 10.13 78 379166 5551 50220329
Femoral hernia incarcerated 12.08 10.13 21 379223 740 50225140
Systemic inflammatory response syndrome 12.06 10.13 12 379232 5037 50220843
Eating disorder 12.01 10.13 67 379177 15342 50210538
Human anti-human antibody test 12.00 10.13 15 379229 390 50225490
Food allergy 11.98 10.13 27 379217 8110 50217770
Pregnancy with contraceptive device 11.85 10.13 8 379236 4071 50221809
Hepatic cytolysis 11.84 10.13 27 379217 8076 50217804
Product complaint 11.82 10.13 45 379199 11421 50214459
Multiple-drug resistance 11.82 10.13 5 379239 3309 50222571
Ulcer 11.82 10.13 215 379029 19985 50205895
Hereditary angioedema 11.82 10.13 14 379230 5428 50220452
Progressive multifocal leukoencephalopathy 11.79 10.13 45 379199 11412 50214468
Cardiac disorder 11.79 10.13 239 379005 42740 50183140
Serum ferritin increased 11.78 10.13 73 379171 5129 50220751
Injection site irritation 11.77 10.13 64 379180 4286 50221594
Renal tubular necrosis 11.76 10.13 38 379206 10130 50215750
Amylase increased 11.76 10.13 14 379230 5416 50220464
Potentiating drug interaction 11.75 10.13 7 379237 3809 50222071
Sexual dysfunction 11.69 10.13 5 379239 3287 50222593
Wound infection pseudomonas 11.69 10.13 28 379216 1245 50224635
Tendon disorder 11.62 10.13 74 379170 5248 50220632
Abnormal dreams 11.59 10.13 34 379210 9343 50216537
Affect lability 11.58 10.13 32 379212 8966 50216914
Endodontic procedure 11.58 10.13 46 379198 2700 50223180
Patent ductus arteriosus 11.58 10.13 58 379186 3762 50222118
Respiratory acidosis 11.56 10.13 17 379227 6011 50219869
Abortion missed 11.55 10.13 32 379212 1556 50224324
Bone lesion 11.55 10.13 13 379231 5157 50220723
Fall 11.54 10.13 2274 376970 332658 49893222
Foot fracture 11.46 10.13 213 379031 19878 50206002
Somnambulism 11.42 10.13 12 379232 4912 50220968
Dermatitis exfoliative 11.41 10.13 13 379231 5129 50220751
Presyncope 11.39 10.13 121 379123 24077 50201803
Abortion threatened 11.38 10.13 17 379227 526 50225354
Head injury 11.35 10.13 120 379124 23900 50201980
Lymphoedema 11.33 10.13 33 379211 9089 50216791
Haemodialysis 11.32 10.13 29 379215 8333 50217547
Peripheral sensory neuropathy 11.31 10.13 20 379224 6571 50219309
Bronchitis 11.31 10.13 917 378327 103242 50122638
Bone density abnormal 11.27 10.13 49 379195 2996 50222884
Hepatitis acute 11.26 10.13 27 379217 7934 50217946
Acute myocardial infarction 11.25 10.13 153 379091 29120 50196760
Ingrown hair 11.25 10.13 16 379228 473 50225407
Plasma cell myeloma recurrent 11.24 10.13 3 379241 2655 50223225
Catheter site erythema 11.20 10.13 8 379236 3954 50221926
Intervertebral disc degeneration 11.20 10.13 152 379092 13309 50212571
Anterior chamber cleavage syndrome 11.19 10.13 10 379234 174 50225706
Pancytopenia 11.19 10.13 752 378492 83278 50142602
Drug-induced liver injury 11.10 10.13 146 379098 27949 50197931
Bradykinesia 11.10 10.13 8 379236 3935 50221945
Coronary arterial stent insertion 11.09 10.13 3 379241 2631 50223249
Pseudomonas infection 11.08 10.13 35 379209 9395 50216485
Paranoia 11.07 10.13 40 379204 10308 50215572
Learning disorder 11.07 10.13 18 379226 600 50225280
Infusion site pruritus 11.06 10.13 8 379236 3929 50221951
Crystal nephropathy 11.04 10.13 21 379223 794 50225086
Carpal tunnel syndrome 11.03 10.13 183 379061 16710 50209170
Rheumatoid lung 10.97 10.13 42 379202 2423 50223457
Restless legs syndrome 10.88 10.13 72 379172 15825 50210055
Pulmonary haemorrhage 10.87 10.13 20 379224 6472 50219408
Acute coronary syndrome 10.87 10.13 35 379209 9339 50216541
Renal disorder 10.85 10.13 143 379101 27362 50198518
Drug screen positive 10.82 10.13 6 379238 3396 50222484
Knee operation 10.79 10.13 68 379176 4805 50221075
Forceps delivery 10.78 10.13 10 379234 183 50225697
Ataxia 10.71 10.13 60 379184 13726 50212154
Abortion incomplete 10.71 10.13 5 379239 3121 50222759
Circulatory collapse 10.68 10.13 97 379147 19903 50205977
Adverse event 10.65 10.13 415 378829 43348 50182532
Trigeminal neuralgia 10.64 10.13 5 379239 3110 50222770
Lung adenocarcinoma 10.64 10.13 60 379184 4074 50221806
Cardiotoxicity 10.61 10.13 23 379221 7004 50218876
Inadequate analgesia 10.61 10.13 3 379241 2555 50223325
Device issue 10.60 10.13 97 379147 19875 50206005
Graft versus host disease in skin 10.59 10.13 3 379241 2553 50223327
Body temperature increased 10.59 10.13 168 379076 31173 50194707
Embedded device 10.58 10.13 4 379240 2833 50223047
Hyperthyroidism 10.58 10.13 51 379193 12124 50213756
Myofascial pain syndrome 10.54 10.13 37 379207 2046 50223834
Placental insufficiency 10.52 10.13 27 379217 1254 50224626
Rhinitis allergic 10.52 10.13 24 379220 7176 50218704
Lung transplant 10.51 10.13 4 379240 2821 50223059
Incorrect product administration duration 10.50 10.13 35 379209 9240 50216640
Alanine aminotransferase abnormal 10.49 10.13 60 379184 4096 50221784
Chills 10.48 10.13 605 378639 96082 50129798
Ileus paralytic 10.41 10.13 9 379235 4041 50221839
Stress at work 10.40 10.13 24 379220 1041 50224839
Nail injury 10.40 10.13 15 379229 449 50225431
Chondropathy 10.37 10.13 37 379207 2063 50223817
Nystagmus 10.36 10.13 16 379228 5545 50220335
Lymphadenectomy 10.36 10.13 22 379222 902 50224978
Troponin increased 10.35 10.13 29 379215 8089 50217791
Threatened labour 10.32 10.13 20 379224 767 50225113
Inflammatory marker increased 10.31 10.13 75 379169 5559 50220321
Ankyloglossia congenital 10.31 10.13 10 379234 194 50225686
Vacuum extractor delivery 10.29 10.13 9 379235 152 50225728
Pulmonary alveolar haemorrhage 10.29 10.13 9 379235 4018 50221862
Pancreatic steatosis 10.28 10.13 22 379222 907 50224973
Dysuria 10.24 10.13 151 379093 28353 50197527
Graft versus host disease in gastrointestinal tract 10.24 10.13 4 379240 2777 50223103
Eosinophil count increased 10.22 10.13 33 379211 8797 50217083
Congenital hydronephrosis 10.20 10.13 14 379230 400 50225480

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 517.89 10.03 691 136695 31461 29405680
Drug abuse 305.25 10.03 16 137370 79867 29357274
Foetal exposure during pregnancy 300.04 10.03 553 136833 33314 29403827
Toxicity to various agents 226.18 10.03 285 137101 173376 29263765
Arthralgia 207.64 10.03 1231 136155 138386 29298755
Completed suicide 205.49 10.03 81 137305 90165 29346976
Psoriatic arthropathy 152.15 10.03 257 137129 14434 29422707
Dysmorphism 130.09 10.03 109 137277 2862 29434279
Drug interaction 107.77 10.03 511 136875 196874 29240267
Sickle cell anaemia with crisis 106.65 10.03 92 137294 2516 29434625
Joint swelling 105.73 10.03 484 136902 49146 29387995
Premature baby 101.03 10.03 238 137148 17042 29420099
Psoriasis 89.55 10.03 341 137045 31886 29405255
Enthesopathy 87.15 10.03 97 137289 3646 29433495
Intentional overdose 85.32 10.03 36 137350 38492 29398649
Exposure during pregnancy 83.77 10.03 146 137240 8408 29428733
Speech disorder developmental 77.43 10.03 67 137319 1840 29435301
Neonatal respiratory distress syndrome 72.46 10.03 89 137297 3721 29433420
Tenosynovitis 72.29 10.03 88 137298 3645 29433496
Blood pressure fluctuation 69.48 10.03 227 137159 19667 29417474
Acute kidney injury 69.40 10.03 844 136542 264423 29172718
Musculoskeletal stiffness 67.32 10.03 348 137038 37110 29400031
Atrial septal defect 65.34 10.03 115 137271 6674 29430467
Hypospadias 65.13 10.03 75 137311 2927 29434214
Foetal anticonvulsant syndrome 64.41 10.03 49 137337 1115 29436026
Death 61.85 10.03 1169 136217 340915 29096226
Overdose 61.57 10.03 179 137207 79640 29357501
Nasopharyngitis 59.82 10.03 478 136908 59187 29377954
Maternal drugs affecting foetus 58.55 10.03 81 137305 3812 29433329
Pain 56.99 10.03 1115 136271 170317 29266824
Autism spectrum disorder 56.75 10.03 58 137328 1974 29435167
Maternal exposure during pregnancy 56.42 10.03 82 137304 4041 29433100
Synovitis 56.21 10.03 143 137243 10747 29426394
Cryptorchism 55.27 10.03 56 137330 1886 29435255
Product use in unapproved indication 54.58 10.03 213 137173 86662 29350479
Low birth weight baby 53.62 10.03 104 137282 6504 29430637
Suicide attempt 53.18 10.03 48 137338 34062 29403079
Small for dates baby 51.64 10.03 73 137313 3506 29433635
C-reactive protein abnormal 50.77 10.03 101 137285 6435 29430706
Learning disorder 50.00 10.03 40 137346 982 29436159
Hypoglycaemia neonatal 49.59 10.03 50 137336 1674 29435467
Drug reaction with eosinophilia and systemic symptoms 49.13 10.03 35 137351 27957 29409184
Serotonin syndrome 48.36 10.03 11 137375 17501 29419640
Tongue disorder 46.53 10.03 80 137306 4556 29432585
Drug resistance 46.30 10.03 21 137365 21519 29415622
Coma 45.94 10.03 70 137316 39380 29397761
Arthritis 45.33 10.03 233 137153 24786 29412355
Ventricular septal defect 45.14 10.03 68 137318 3461 29433680
Maternal exposure during breast feeding 44.41 10.03 44 137342 1442 29435699
Rhabdomyolysis 42.20 10.03 143 137243 60665 29376476
Hepatic function abnormal 41.67 10.03 74 137312 39185 29397956
Palmar-plantar erythrodysaesthesia syndrome 41.30 10.03 9 137377 14750 29422391
Foot deformity 41.24 10.03 70 137316 3945 29433196
Syndactyly 39.35 10.03 31 137355 744 29436397
Haemoglobin decreased 38.73 10.03 713 136673 107662 29329479
Arthropathy 38.54 10.03 200 137186 21354 29415787
Pulmonary fibrosis 38.53 10.03 159 137227 15423 29421718
Basal cell carcinoma 38.29 10.03 168 137218 16742 29420399
Lower respiratory tract infection 38.16 10.03 232 137154 26270 29410871
Blood pressure systolic increased 37.88 10.03 167 137219 16678 29420463
Rheumatoid nodule 37.85 10.03 48 137338 2074 29435067
Developmental delay 37.28 10.03 52 137334 2466 29434675
Pancytopenia 36.60 10.03 566 136820 82602 29354539
Febrile neutropenia 36.58 10.03 339 137047 111901 29325240
Drug intolerance 35.85 10.03 363 137023 48016 29389125
Exposure via breast milk 35.85 10.03 42 137344 1670 29435471
Intentional product misuse 35.30 10.03 67 137319 34594 29402547
Osteoarthritis 35.20 10.03 172 137214 17931 29419210
Intellectual disability 34.60 10.03 34 137352 1103 29436038
Drug dependence 34.56 10.03 28 137358 20953 29416188
Bradycardia 34.49 10.03 172 137214 65457 29371684
Joint laxity 34.43 10.03 22 137364 374 29436767
Congenital hand malformation 33.35 10.03 25 137361 556 29436585
Infusion related reaction 33.34 10.03 331 137055 43555 29393586
Talipes 32.70 10.03 41 137345 1751 29435390
Foetal growth restriction 32.69 10.03 61 137325 3705 29433436
Tendonitis 32.57 10.03 96 137290 7865 29429276
Alanine aminotransferase abnormal 32.31 10.03 53 137333 2904 29434237
Angioedema 32.23 10.03 62 137324 31853 29405288
Jaundice neonatal 31.76 10.03 34 137352 1222 29435919
Hypermobility syndrome 31.41 10.03 20 137366 338 29436803
Blood pressure systolic abnormal 31.06 10.03 44 137342 2117 29435024
Blood pressure increased 30.47 10.03 497 136889 73306 29363835
Renal failure 29.90 10.03 380 137006 118219 29318922
Off label use 29.83 10.03 1120 136266 299680 29137461
Language disorder 29.82 10.03 41 137345 1918 29435223
Drug withdrawal syndrome 29.62 10.03 24 137362 17960 29419181
Cytomegalovirus infection 29.19 10.03 39 137347 23176 29413965
Suicidal ideation 28.88 10.03 75 137311 34641 29402500
Joint effusion 28.21 10.03 61 137325 4123 29433018
Pain in extremity 27.94 10.03 691 136695 109742 29327399
Large for dates baby 27.88 10.03 27 137359 860 29436281
Plagiocephaly 27.49 10.03 21 137365 481 29436660
Polyarthritis 27.15 10.03 58 137328 3887 29433254
Respiratory arrest 27.13 10.03 49 137337 25784 29411357
Hyperglycaemia 27.07 10.03 76 137310 34211 29402930
Lactic acidosis 27.00 10.03 63 137323 30184 29406957
Agitation 26.64 10.03 135 137251 51169 29385972
Serum ferritin increased 26.41 10.03 71 137315 5517 29431624
Hyperbilirubinaemia neonatal 26.02 10.03 24 137362 718 29436423
Immune reconstitution inflammatory syndrome 25.77 10.03 3 137383 7799 29429342
Selective eating disorder 25.61 10.03 35 137351 1628 29435513
Knee deformity 25.43 10.03 21 137365 540 29436601
Sedation 25.37 10.03 26 137360 17379 29419762
Cardiac failure 25.16 10.03 241 137145 79046 29358095
Peripheral swelling 24.76 10.03 425 136961 63314 29373827
Knee arthroplasty 24.68 10.03 71 137315 5738 29431403
Skin cancer 24.67 10.03 91 137295 8377 29428764
Hypoglycaemia 24.66 10.03 128 137258 48218 29388923
Caesarean section 24.52 10.03 37 137349 1886 29435255
Loss of personal independence in daily activities 24.49 10.03 202 137184 25238 29411903
Delirium 24.46 10.03 97 137289 39300 29397841
Motor developmental delay 24.42 10.03 22 137364 638 29436503
Hand deformity 24.39 10.03 39 137347 2091 29435050
Musculoskeletal pain 24.28 10.03 223 137163 28730 29408411
Dysgraphia 24.28 10.03 38 137348 2000 29435141
Astigmatism 23.95 10.03 26 137360 950 29436191
Psychotic disorder 23.80 10.03 36 137350 20318 29416823
Strabismus 23.64 10.03 31 137355 1385 29435756
Behaviour disorder 23.56 10.03 52 137334 3564 29433577
Drug withdrawal syndrome neonatal 23.47 10.03 50 137336 3345 29433796
Body temperature decreased 23.43 10.03 105 137281 10559 29426582
Somnolence 23.31 10.03 302 137084 93653 29343488
Constipation 23.08 10.03 382 137004 113778 29323363
Disease progression 22.72 10.03 257 137129 81659 29355482
Hydrocele 22.69 10.03 36 137350 1917 29435224
Poisoning 22.66 10.03 9 137377 9984 29427157
Otitis media 22.55 10.03 42 137344 2547 29434594
C-reactive protein increased 22.52 10.03 309 137077 43954 29393187
Hypotonia neonatal 22.05 10.03 28 137358 1211 29435930
Urticaria 21.96 10.03 156 137230 54504 29382637
Blood pressure diastolic decreased 21.76 10.03 77 137309 6945 29430196
Blood pressure diastolic abnormal 21.74 10.03 41 137345 2510 29434631
Cardiac arrest 21.64 10.03 274 137112 85317 29351824
Anal fistula 21.56 10.03 55 137331 4140 29433001
Substance abuse 21.48 10.03 3 137383 6784 29430357
Medical device implantation 20.95 10.03 19 137367 556 29436585
Cleft lip 20.91 10.03 15 137371 311 29436830
Pathogen resistance 20.68 10.03 6 137380 8110 29429031
Dyslexia 20.67 10.03 15 137371 317 29436824
Altered state of consciousness 20.64 10.03 38 137348 19851 29417290
Agitation neonatal 20.62 10.03 25 137361 1031 29436110
Depressed level of consciousness 20.45 10.03 95 137291 36847 29400294
Crohn's disease 20.44 10.03 44 137342 2965 29434176
Dyspraxia 20.27 10.03 16 137370 385 29436756
Blood creatine phosphokinase increased 19.95 10.03 109 137277 40535 29396606
Heart rate decreased 19.95 10.03 190 137196 24722 29412419
Arthritis bacterial 19.78 10.03 55 137331 4358 29432783
Wound 19.57 10.03 109 137277 11954 29425187
Bronchiolitis 19.54 10.03 41 137345 2714 29434427
Juvenile idiopathic arthritis 19.47 10.03 28 137358 1366 29435775
Foetal disorder 19.46 10.03 21 137365 762 29436379
Neuroleptic malignant syndrome 19.43 10.03 28 137358 16120 29421021
Attention deficit hyperactivity disorder 19.36 10.03 36 137350 2181 29434960
Patent ductus arteriosus 19.25 10.03 44 137342 3087 29434054
Colitis ulcerative 19.16 10.03 113 137273 12656 29424485
Congenital anomaly 19.03 10.03 27 137359 1301 29435840
Lacrimal disorder 18.77 10.03 14 137372 309 29436832
Shock 18.77 10.03 45 137341 21359 29415782
Multiple organ dysfunction syndrome 18.70 10.03 195 137191 62921 29374220
Post procedural infection 18.66 10.03 53 137333 4252 29432889
Renal aplasia 18.58 10.03 19 137367 647 29436494
Congenital bladder anomaly 18.52 10.03 13 137373 260 29436881
Psychomotor retardation 18.50 10.03 42 137344 2934 29434207
Limb reduction defect 18.48 10.03 13 137373 261 29436880
Malignant melanoma 18.44 10.03 74 137312 7087 29430054
Microcephaly 18.44 10.03 20 137366 730 29436411
Acute hepatic failure 18.41 10.03 17 137369 11935 29425206
Weight decrease neonatal 18.39 10.03 14 137372 319 29436822
Haematocrit decreased 18.35 10.03 211 137175 28811 29408330
Vitamin D deficiency 18.33 10.03 62 137324 5467 29431674
Rash maculo-papular 18.32 10.03 55 137331 24234 29412907
Tuberculosis 18.24 10.03 74 137312 7122 29430019
Congenital foot malformation 18.15 10.03 15 137371 386 29436755
Renal impairment 17.83 10.03 268 137118 81065 29356076
Lung neoplasm malignant 17.78 10.03 121 137265 14236 29422905
Intentional self-injury 17.73 10.03 19 137367 12442 29424699
Septic arthritis staphylococcal 17.68 10.03 16 137370 467 29436674
Blood pressure diastolic increased 17.58 10.03 47 137339 3639 29433502
Polydactyly 17.57 10.03 24 137362 1116 29436025
Ankyloglossia congenital 17.54 10.03 13 137373 284 29436857
Back disorder 17.24 10.03 64 137322 5909 29431232
Nasal disorder 17.24 10.03 27 137359 1422 29435719
Haemangioma congenital 17.23 10.03 16 137370 483 29436658
Scoliosis 17.22 10.03 35 137351 2265 29434876
Cellulitis 17.20 10.03 304 137082 45536 29391605
Diaphragmatic disorder 17.18 10.03 22 137364 960 29436181
Electrocardiogram QT prolonged 17.14 10.03 98 137288 36039 29401102
Grip strength decreased 17.14 10.03 35 137351 2272 29434869
Infective pulmonary exacerbation of cystic fibrosis 17.05 10.03 4 137382 6232 29430909
Joint range of motion decreased 16.75 10.03 64 137322 5990 29431151
Inflammation 16.57 10.03 170 137216 22558 29414583
Multiple congenital abnormalities 16.56 10.03 16 137370 508 29436633
Arthrodesis 16.42 10.03 15 137371 443 29436698
Diabetic ketoacidosis 16.42 10.03 31 137355 16042 29421099
Bradycardia neonatal 16.35 10.03 21 137365 919 29436222
Hallucination 16.35 10.03 131 137255 44581 29392560
Joint stiffness 16.31 10.03 87 137299 9386 29427755
Injection site pain 16.29 10.03 226 137160 32220 29404921
Umbilical hernia 16.20 10.03 46 137340 3689 29433452
Respiratory disorder neonatal 16.19 10.03 26 137360 1399 29435742
Pectus excavatum 16.03 10.03 11 137375 212 29436929
Neurotoxicity 16.00 10.03 27 137359 14586 29422555
Pneumonia 15.94 10.03 1709 135677 318463 29118678
No adverse event 15.92 10.03 36 137350 17442 29419699
Vitamin B12 deficiency 15.90 10.03 42 137344 3229 29433912
C-reactive protein decreased 15.88 10.03 27 137359 1524 29435617
Status epilepticus 15.87 10.03 16 137370 10778 29426363
Hepatic failure 15.74 10.03 84 137302 31428 29405713
Respiratory rate increased 15.70 10.03 81 137305 8627 29428514
Hypertelorism 15.69 10.03 16 137370 543 29436598
Spinal disorder 15.54 10.03 45 137341 3650 29433491
Ear disorder 15.52 10.03 24 137362 1250 29435891
Weight decreased 15.48 10.03 853 136533 150052 29287089
Neck mass 15.45 10.03 26 137360 1455 29435686
Haemangioma 15.41 10.03 28 137358 1666 29435475
Oesophageal fibrosis 15.35 10.03 10 137376 176 29436965
Red blood cell sedimentation rate increased 15.30 10.03 72 137314 7389 29429752
Immunodeficiency 14.90 10.03 50 137336 4390 29432751
Maternal exposure timing unspecified 14.90 10.03 13 137373 361 29436780
Ankylosing spondylitis 14.89 10.03 48 137338 4128 29433013
Poor venous access 14.77 10.03 40 137346 3121 29434020
Oropharyngeal pain 14.71 10.03 204 137182 29081 29408060
Arnold-Chiari malformation 14.55 10.03 12 137374 308 29436833
Therapeutic product effect decreased 14.33 10.03 204 137182 29247 29407894
Hernia pain 14.29 10.03 11 137375 255 29436886
Prostate cancer 14.14 10.03 181 137205 25346 29411795
Oxygen saturation decreased 14.11 10.03 290 137096 44647 29392494
Inguinal hernia 14.06 10.03 65 137321 6623 29430518
Proteinuria 14.03 10.03 33 137353 15771 29421370
Infection 14.03 10.03 461 136925 76290 29360851
Drug ineffective for unapproved indication 14.01 10.03 28 137358 14186 29422955
Contraindicated product administered 13.98 10.03 138 137248 18128 29419013
Cerebral haemorrhage 13.97 10.03 87 137299 31339 29405802
Pharyngeal disorder 13.96 10.03 16 137370 621 29436520
Mouth ulceration 13.87 10.03 89 137297 10266 29426875
Foetal distress syndrome 13.86 10.03 20 137366 979 29436162
Emphysema 13.83 10.03 78 137308 8593 29428548
Toxic epidermal necrolysis 13.77 10.03 41 137345 18112 29419029
Vascular insufficiency 13.73 10.03 12 137374 334 29436807
Foetal heart rate deceleration abnormality 13.73 10.03 14 137372 475 29436666
Lung cancer metastatic 13.72 10.03 33 137353 2394 29434747
Blood parathyroid hormone decreased 13.69 10.03 18 137368 806 29436335
Ear infection 13.68 10.03 74 137312 8026 29429115
Pyrexia 13.59 10.03 1151 136235 286471 29150670
Anal atresia 13.51 10.03 11 137375 277 29436864
Spina bifida 13.50 10.03 12 137374 342 29436799
Arthritis infective 13.46 10.03 36 137350 2788 29434353
Tooth malformation 13.41 10.03 9 137377 167 29436974
Radiation inflammation 13.36 10.03 10 137376 222 29436919
Blood insulin increased 13.35 10.03 12 137374 347 29436794
Pleural fibrosis 13.35 10.03 23 137363 1312 29435829
Injection site bruising 13.31 10.03 70 137316 7510 29429631
Peripheral artery thrombosis 13.25 10.03 30 137356 2092 29435049
Finger deformity 13.23 10.03 21 137365 1119 29436022
Diverticular perforation 13.19 10.03 37 137349 2947 29434194
Unresponsive to stimuli 13.10 10.03 66 137320 25060 29412081
Venoocclusive liver disease 13.01 10.03 8 137378 6909 29430232
Developmental coordination disorder 13.00 10.03 9 137377 176 29436965
Steatorrhoea 12.86 10.03 16 137370 678 29436463
Ear malformation 12.84 10.03 11 137375 298 29436843
Haemolysis 12.75 10.03 65 137321 6891 29430250
Osteonecrosis of jaw 12.73 10.03 37 137349 16473 29420668
Congenital hydronephrosis 12.69 10.03 16 137370 687 29436454
Palindromic rheumatism 12.57 10.03 9 137377 186 29436955
Gangrene neonatal 12.33 10.03 9 137377 192 29436949
Red blood cell sedimentation rate 12.29 10.03 14 137372 540 29436601
Excessive cerumen production 12.08 10.03 10 137376 258 29436883
Neonatal seizure 12.06 10.03 13 137373 471 29436670
Pulmonary artery stenosis congenital 12.02 10.03 13 137373 473 29436668
Sexual dysfunction 11.98 10.03 6 137380 5808 29431333
Neutropenia neonatal 11.94 10.03 15 137371 642 29436499
Neonatal infection 11.92 10.03 12 137374 401 29436740
Dermatitis psoriasiform 11.90 10.03 20 137366 1118 29436023
Malignant neoplasm progression 11.87 10.03 257 137129 73602 29363539
Meningeal disorder 11.85 10.03 11 137375 332 29436809
Decreased appetite 11.84 10.03 553 136833 144789 29292352
Kidney infection 11.74 10.03 48 137338 4635 29432506
Aggression 11.71 10.03 107 137279 35434 29401707
Cleft palate 11.69 10.03 14 137372 570 29436571
Irritability 11.66 10.03 58 137328 22094 29415047
Progressive multifocal leukoencephalopathy 11.63 10.03 14 137372 8705 29428436
Vomiting 11.63 10.03 839 136547 211421 29225720
Hypermetropia 11.61 10.03 12 137374 414 29436727
Lipase increased 11.54 10.03 13 137373 8324 29428817
Hepatocellular injury 11.54 10.03 55 137331 21188 29415953
Wrong technique in product usage process 11.52 10.03 92 137294 31336 29405805
Non-Hodgkin's lymphoma 11.47 10.03 23 137363 1474 29435667
Neck pain 11.43 10.03 151 137235 21296 29415845
Abnormal behaviour 11.36 10.03 62 137324 23065 29414076
Low set ears 11.35 10.03 12 137374 425 29436716
Product quality issue 11.28 10.03 37 137349 15858 29421283
Pharyngitis 11.26 10.03 63 137323 6920 29430221
Educational problem 11.15 10.03 13 137373 514 29436627
Hypertriglyceridaemia 11.08 10.03 11 137375 7464 29429677
Cholelithiasis 11.03 10.03 134 137252 18538 29418603
Nephrolithiasis 10.97 10.03 172 137214 25162 29411979
Pyelocaliectasis 10.95 10.03 19 137367 1090 29436051
Synovial cyst 10.94 10.03 26 137360 1871 29435270
Anaphylactic shock 10.94 10.03 29 137357 13307 29423834
Foetal hypokinesia 10.94 10.03 11 137375 367 29436774
Fine motor skill dysfunction 10.90 10.03 23 137363 1528 29435613
Hepatic enzyme increased 10.90 10.03 219 137167 33580 29403561
Incorrect route of product administration 10.89 10.03 21 137365 10780 29426361
Glycosylated haemoglobin increased 10.71 10.03 17 137369 9409 29427732
Pulmonary tuberculosis 10.64 10.03 44 137342 4271 29432870
Pancreatic duct stenosis 10.63 10.03 8 137378 179 29436962
Tonsil cancer 10.60 10.03 17 137369 914 29436227
Oesophageal atresia 10.57 10.03 12 137374 461 29436680
Chronic obstructive pulmonary disease 10.56 10.03 257 137129 40698 29396443
Granuloma skin 10.53 10.03 14 137372 634 29436507
Acute chest syndrome 10.52 10.03 10 137376 311 29436830
Lung neoplasm 10.50 10.03 44 137342 4296 29432845
Tachycardia 10.50 10.03 256 137130 72154 29364987
Upper respiratory tract infection 10.48 10.03 182 137204 27167 29409974
Joint instability 10.44 10.03 11 137375 388 29436753
Localised infection 10.39 10.03 104 137282 13712 29423429
Nose deformity 10.37 10.03 8 137378 186 29436955
Moaning 10.37 10.03 15 137371 736 29436405
Maternal exposure before pregnancy 10.35 10.03 12 137374 472 29436669
Cerebral ventricle dilatation 10.34 10.03 16 137370 834 29436307
Aspergillus infection 10.30 10.03 21 137365 10560 29426581
Back pain 10.25 10.03 577 136809 101707 29335434
Chronic graft versus host disease 10.23 10.03 3 137383 4026 29433115
Suspected suicide 10.19 10.03 3 137383 4017 29433124
Transfusion-related circulatory overload 10.19 10.03 8 137378 191 29436950
Respiratory failure 10.17 10.03 359 137027 96772 29340369
Mean cell volume increased 10.17 10.03 30 137356 2459 29434682
Myoclonus 10.14 10.03 30 137356 13279 29423862
Retinopathy hypertensive 10.14 10.03 9 137377 256 29436885
Mesothelioma 10.13 10.03 11 137375 402 29436739
Skin graft failure 10.11 10.03 7 137379 137 29437004
Adenovirus infection 10.09 10.03 4 137382 4443 29432698
Hyperammonaemia 10.04 10.03 7 137379 5656 29431485
Blood test abnormal 10.03 10.03 53 137333 5696 29431445

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1283.64 9.90 2954 383094 161340 63951344
Completed suicide 888.51 9.90 140 385908 224274 63888410
Pemphigus 819.68 9.90 1375 384673 59326 64053358
Arthropathy 817.20 9.90 2057 383991 118910 63993774
Systemic lupus erythematosus 793.46 9.90 1558 384490 76054 64036630
Joint swelling 790.66 9.90 2957 383091 212425 63900259
Hand deformity 758.79 9.90 1354 384694 61417 64051267
Synovitis 736.20 9.90 1748 384300 97342 64015342
Toxicity to various agents 730.24 9.90 661 385387 362852 63749832
Glossodynia 692.09 9.90 1324 384724 63372 64049312
Arthralgia 678.35 9.90 4747 381301 437513 63675171
Maternal exposure during pregnancy 638.52 9.90 1622 384426 94262 64018422
Drug abuse 618.96 9.90 45 386003 132329 63980355
Infusion related reaction 614.83 9.90 2272 383776 162195 63950489
Anti-cyclic citrullinated peptide antibody positive 570.79 9.90 1047 385001 48515 64064169
Wound 559.15 9.90 1341 384707 75136 64037548
Pericarditis 537.68 9.90 1169 384879 61347 64051337
Pain 493.77 9.90 5269 380779 548242 63564442
Abdominal discomfort 454.50 9.90 2227 383821 180095 63932589
Alopecia 425.26 9.90 2041 384007 163649 63949035
Swelling 397.79 9.90 1955 384093 158263 63954421
Therapeutic product effect decreased 394.88 9.90 1550 384498 113801 63998883
Nasopharyngitis 393.49 9.90 2256 383792 193817 63918867
Contraindicated product administered 392.11 9.90 1477 384571 106352 64006332
Discomfort 382.35 9.90 1209 384839 79669 64033015
Drug interaction 363.06 9.90 1043 385005 361040 63751644
Death 344.01 9.90 1603 384445 481102 63631582
Rheumatoid factor positive 340.75 9.90 688 385360 34250 64078434
Drug intolerance 332.41 9.90 2093 383955 185899 63926785
Duodenal ulcer perforation 329.58 9.90 675 385373 33950 64078734
Exposure during pregnancy 329.33 9.90 1119 384929 76556 64036128
Helicobacter infection 328.22 9.90 716 385332 37646 64075038
Musculoskeletal stiffness 309.69 9.90 1509 384539 121697 63990987
Intentional overdose 306.10 9.90 80 385968 89864 64022820
Hepatic enzyme increased 296.03 9.90 1548 384500 128395 63984289
Acute kidney injury 258.26 9.90 1603 384445 447637 63665047
C-reactive protein abnormal 255.17 9.90 548 385500 28499 64084185
Psoriatic arthropathy 247.22 9.90 692 385356 42589 64070095
Sinusitis 225.89 9.90 1572 384476 144356 63968328
Impaired healing 220.23 9.90 829 385219 59644 64053040
Overdose 218.88 9.90 387 385661 159179 63953505
Febrile neutropenia 209.45 9.90 512 385536 187145 63925539
Lower respiratory tract infection 204.38 9.90 1111 384937 93503 64019181
Product use issue 195.49 9.90 1565 384483 150150 63962534
Red blood cell sedimentation rate abnormal 194.66 9.90 350 385698 15956 64096728
Cardiac arrest 194.31 9.90 393 385655 153671 63959013
Treatment failure 193.64 9.90 1280 384768 115536 63997148
Hypersensitivity 191.18 9.90 1906 384142 194546 63918138
Peripheral swelling 189.62 9.90 2000 384048 207153 63905531
Blood pressure fluctuation 179.77 9.90 700 385348 51171 64061513
Muscle injury 178.67 9.90 450 385598 25987 64086697
Arthritis 172.20 9.90 971 385077 82843 64029841
Suicide attempt 171.94 9.90 106 385942 70901 64041783
Depressed level of consciousness 171.69 9.90 141 385907 81295 64031389
Sickle cell anaemia with crisis 170.29 9.90 184 385864 5148 64107536
Drug ineffective 165.85 9.90 6365 379683 833882 63278802
Folliculitis 164.06 9.90 473 385575 29604 64083080
Bradycardia 160.03 9.90 289 385759 117930 63994754
Sleep disorder due to general medical condition, insomnia type 157.92 9.90 428 385620 25842 64086842
Hip arthroplasty 156.56 9.90 375 385673 20976 64091708
Knee arthroplasty 156.46 9.90 434 385614 26565 64086119
Irritable bowel syndrome 154.50 9.90 534 385514 36835 64075849
Psoriasis 146.17 9.90 829 385219 70874 64041810
Weight increased 141.79 9.90 1923 384125 211425 63901259
Pregnancy 140.83 9.90 355 385693 20510 64092174
Respiratory arrest 139.95 9.90 71 385977 52914 64059770
Rhabdomyolysis 134.49 9.90 213 385835 91513 64021171
Blister 134.01 9.90 887 385161 80080 64032604
Lactic acidosis 133.62 9.90 103 385945 61307 64051377
Drug reaction with eosinophilia and systemic symptoms 132.56 9.90 80 385968 54137 64058547
Abortion spontaneous 130.04 9.90 388 385660 24755 64087929
Osteoarthritis 129.57 9.90 733 385315 62603 64050081
Renal failure 129.19 9.90 603 385445 181085 63931599
Cardiac failure 126.79 9.90 389 385659 131984 63980700
Injection site erythema 124.13 9.90 787 385261 70013 64042671
Infection 123.46 9.90 1668 384380 183212 63929472
Sopor 120.68 9.90 17 386031 29644 64083040
Sedation 114.95 9.90 52 385996 41410 64071274
Malignant neoplasm progression 111.46 9.90 327 385721 112544 64000140
Hepatic function abnormal 109.62 9.90 134 385914 64179 64048505
Disease progression 108.69 9.90 457 385591 141223 63971461
Serotonin syndrome 107.76 9.90 50 385998 39232 64073452
Blood pressure systolic increased 107.61 9.90 582 385466 48871 64063813
Ill-defined disorder 107.32 9.90 535 385513 43517 64069167
Contusion 105.61 9.90 1095 384953 112870 63999814
Red blood cell sedimentation rate increased 105.36 9.90 418 385630 30817 64081867
Enthesopathy 105.13 9.90 199 385849 9439 64103245
Drug resistance 100.52 9.90 42 386006 35060 64077624
Neutropenia 99.53 9.90 935 385113 238689 63873995
Agitation 99.37 9.90 240 385808 88127 64024557
Constipation 99.09 9.90 886 385162 228451 63884233
Injection site pruritus 97.59 9.90 467 385581 37359 64075325
Injection site pain 96.03 9.90 1055 384993 110353 64002331
Hypoglycaemia 95.76 9.90 251 385797 89641 64023043
Joint effusion 92.78 9.90 231 385817 13242 64099442
Cytomegalovirus infection 92.19 9.90 54 385994 37145 64075539
Product use in unapproved indication 91.71 9.90 649 385399 175969 63936715
Condition aggravated 90.87 9.90 2893 383155 369533 63743151
Juvenile idiopathic arthritis 90.64 9.90 114 385934 3765 64108919
Blood pressure diastolic abnormal 90.29 9.90 212 385836 11705 64100979
Fatigue 89.97 9.90 5403 380645 743327 63369357
Hypotension 89.04 9.90 1675 384373 379299 63733385
Live birth 88.93 9.90 203 385845 11001 64101683
Intentional product misuse 88.90 9.90 187 385861 72108 64040576
Renal impairment 87.95 9.90 462 385586 134555 63978129
Drug dependence 87.43 9.90 45 386003 33267 64079417
Rash 86.72 9.90 3460 382588 455089 63657595
Blood pressure systolic abnormal 86.65 9.90 187 385861 9755 64102929
Rheumatic fever 85.85 9.90 179 385869 9115 64103569
Coma 85.65 9.90 255 385793 87360 64025324
Osteoporosis 85.39 9.90 486 385562 41594 64071090
Pain in extremity 85.14 9.90 2396 383652 300689 63811995
Hyponatraemia 85.10 9.90 529 385519 147810 63964874
Respiratory failure 84.80 9.90 590 385458 160593 63952091
Hepatic failure 84.67 9.90 125 385923 55269 64057415
Cardio-respiratory arrest 84.66 9.90 303 385745 98090 64014594
Hyperglycaemia 84.32 9.90 147 385901 60821 64051863
Multiple organ dysfunction syndrome 84.17 9.90 317 385731 101096 64011588
Rheumatoid nodule 83.04 9.90 213 385835 12438 64100246
Musculoskeletal pain 82.99 9.90 797 385251 80497 64032187
Injection site reaction 82.58 9.90 520 385528 46144 64066540
Disability assessment scale score increased 82.01 9.90 88 385960 2442 64110242
Somnolence 80.57 9.90 804 385244 202841 63909843
Electrocardiogram QT prolonged 80.01 9.90 228 385820 79220 64033464
Injection site swelling 79.62 9.90 471 385577 40882 64071802
Tenosynovitis 78.47 9.90 200 385848 11633 64101051
Intentional self-injury 78.08 9.90 38 386010 29006 64083678
Swollen joint count increased 78.05 9.90 154 385894 7535 64105149
Grip strength decreased 77.58 9.90 198 385850 11526 64101158
Fibromyalgia 76.71 9.90 419 385629 35312 64077372
Blood pressure diastolic decreased 76.47 9.90 300 385748 22001 64090683
Caesarean section 76.27 9.90 192 385856 11082 64101602
Joint stiffness 75.29 9.90 371 385677 30033 64082651
Palmar-plantar erythrodysaesthesia syndrome 74.06 9.90 40 386008 28779 64083905
Poisoning 73.39 9.90 20 386028 21859 64090825
Foot deformity 72.75 9.90 241 385807 16263 64096421
Localised infection 71.14 9.90 363 385685 29798 64082886
Heart rate decreased 69.72 9.90 566 385482 54501 64058183
Device expulsion 69.63 9.90 20 386028 21116 64091568
Joint laxity 68.95 9.90 77 385971 2237 64110447
Drug withdrawal syndrome 68.68 9.90 52 385996 31239 64081445
Neoplasm progression 68.08 9.90 87 385961 40877 64071807
C-reactive protein increased 67.75 9.90 867 385181 94042 64018642
Blood pressure increased 67.36 9.90 1427 384621 171125 63941559
Hypoxia 67.16 9.90 285 385763 87864 64024820
Tachycardia 66.27 9.90 574 385474 149005 63963679
Disseminated intravascular coagulation 65.72 9.90 58 385990 32290 64080394
Altered state of consciousness 65.61 9.90 78 385970 37824 64074860
Inflammation 65.56 9.90 638 385410 64662 64048022
Shock 64.82 9.90 80 385968 38160 64074524
Injection site bruising 62.92 9.90 403 385645 35970 64076714
Delirium 62.27 9.90 209 385839 68985 64043699
Basal cell carcinoma 61.80 9.90 355 385693 30483 64082201
Gastrointestinal disorder 61.31 9.90 813 385235 88896 64023788
Bone erosion 60.97 9.90 180 385868 11415 64101269
Loss of personal independence in daily activities 60.07 9.90 681 385367 71773 64040911
Metabolic acidosis 60.05 9.90 220 385828 70738 64041946
Respiratory depression 59.57 9.90 33 386015 23410 64089274
Gestational diabetes 59.22 9.90 114 385934 5476 64107208
Polyarthritis 59.10 9.90 159 385889 9556 64103128
Immune reconstitution inflammatory syndrome 58.94 9.90 4 386044 12466 64100218
Femur fracture 58.92 9.90 378 385670 33757 64078927
Encephalopathy 58.34 9.90 170 385878 58649 64054035
Cardiac failure congestive 58.32 9.90 500 385548 130080 63982604
Thrombocytopenia 58.24 9.90 965 385083 222836 63889848
Cholestasis 57.78 9.90 113 385935 44759 64067925
Tongue disorder 57.41 9.90 181 385867 11899 64100785
Mydriasis 57.34 9.90 11 386037 15301 64097383
Angioedema 56.13 9.90 186 385862 61635 64051049
Neuropathy peripheral 55.68 9.90 443 385605 117082 63995602
Blood creatine phosphokinase increased 55.39 9.90 173 385875 58385 64054299
Oropharyngeal pain 55.29 9.90 792 385256 88075 64024609
Syncope 55.22 9.90 640 385408 156995 63955689
Cerebral haemorrhage 54.90 9.90 142 385906 50948 64061736
Blood pressure diastolic increased 54.72 9.90 165 385883 10587 64102097
Hyperhidrosis 54.16 9.90 482 385566 124438 63988246
Acute hepatic failure 54.04 9.90 46 386002 26066 64086618
Hepatocellular injury 53.95 9.90 119 385929 45116 64067568
Stomatitis 53.51 9.90 938 385110 108667 64004017
Tendonitis 53.47 9.90 252 385796 20030 64092654
Cognitive disorder 53.34 9.90 161 385887 54926 64057758
Tremor 53.02 9.90 599 385449 147631 63965053
Body temperature decreased 51.65 9.90 298 385750 25630 64087054
Premature delivery 51.25 9.90 234 385814 18355 64094329
Anaemia 50.83 9.90 1805 384243 376875 63735809
Neuroleptic malignant syndrome 50.56 9.90 45 386003 24951 64087733
Diabetic ketoacidosis 49.99 9.90 63 385985 29782 64082902
Pulmonary fibrosis 49.82 9.90 328 385720 29550 64083134
Injection site rash 48.60 9.90 205 385843 15537 64097147
Hallucination 48.54 9.90 247 385801 72541 64040143
Joint injury 48.52 9.90 268 385780 22679 64090005
Pre-eclampsia 48.46 9.90 112 385936 6119 64106565
Disturbance in attention 48.21 9.90 109 385939 40965 64071719
Nodule 48.06 9.90 224 385824 17723 64094961
Herpes zoster 47.78 9.90 702 385346 78485 64034199
Vomiting 47.69 9.90 2756 383292 548361 63564323
Joint destruction 45.91 9.90 80 385968 3556 64109128
Synovial cyst 45.75 9.90 125 385923 7582 64105102
Tenderness 45.58 9.90 235 385813 19367 64093317
Restlessness 45.55 9.90 107 385941 39678 64073006
Post transplant lymphoproliferative disorder 45.29 9.90 3 386045 9541 64103143
Infective pulmonary exacerbation of cystic fibrosis 45.19 9.90 8 386040 11788 64100896
Myocardial infarction 44.78 9.90 710 385338 165111 63947573
Abnormal behaviour 44.75 9.90 83 385965 33539 64079145
Maternal exposure before pregnancy 44.46 9.90 77 385971 3406 64109278
Fracture 44.42 9.90 226 385822 18529 64094155
Ventricular tachycardia 44.37 9.90 86 385962 34179 64078505
Neck deformity 44.35 9.90 53 385995 1659 64111025
Myalgia 44.24 9.90 675 385373 157942 63954742
Anxiety 44.20 9.90 901 385147 201748 63910936
Disability 43.57 9.90 166 385882 12006 64100678
Skin ulcer 43.33 9.90 428 385620 43546 64069138
Asthenia 42.52 9.90 2111 383937 425933 63686751
Speech disorder 42.44 9.90 148 385900 48293 64064391
Dyspnoea 42.24 9.90 3716 382332 714958 63397726
Hyperkalaemia 42.18 9.90 394 385654 100735 64011949
Alanine aminotransferase abnormal 42.17 9.90 113 385935 6775 64105909
Red blood cell sedimentation rate 42.15 9.90 78 385970 3636 64109048
Myoclonus 42.09 9.90 53 385995 25065 64087619
Brain oedema 42.00 9.90 42 386006 22033 64090651
Sedation complication 41.97 9.90 6 386042 10348 64102336
Premature labour 41.70 9.90 120 385928 7500 64105184
Dizziness 41.66 9.90 2127 383921 428036 63684648
Joint range of motion decreased 41.63 9.90 227 385821 19116 64093568
Laryngitis 40.78 9.90 152 385896 10879 64101805
Mental status changes 40.53 9.90 208 385840 60954 64051730
Premature rupture of membranes 40.46 9.90 77 385971 3667 64109017
Unresponsive to stimuli 40.21 9.90 160 385888 50233 64062451
Limb deformity 39.93 9.90 72 385976 3289 64109395
Leukopenia 39.88 9.90 400 385648 100842 64011842
Hypothermia 39.86 9.90 36 386012 19820 64092864
Neurotoxicity 39.80 9.90 64 385984 27340 64085344
Disorientation 39.80 9.90 185 385863 55643 64057041
Hypokalaemia 39.61 9.90 503 385545 121400 63991284
Decreased appetite 39.50 9.90 1333 384715 279956 63832728
Poor venous access 39.35 9.90 163 385885 12254 64100430
Multiple sclerosis relapse 39.27 9.90 121 385927 41014 64071670
Seizure 39.12 9.90 733 385315 166159 63946525
Orthostatic hypotension 38.83 9.90 146 385902 46592 64066092
Irritability 38.82 9.90 103 385945 36643 64076041
Arthritis infective 38.76 9.90 111 385937 6919 64105765
Neck mass 38.66 9.90 79 385969 3965 64108719
Substance abuse 38.57 9.90 5 386043 9287 64103397
Dehydration 38.47 9.90 995 385053 215768 63896916
Bronchitis 38.19 9.90 886 385162 107857 64004827
Venoocclusive liver disease 37.92 9.90 7 386041 10008 64102676
Diarrhoea 37.87 9.90 3769 382279 718935 63393749
Smear cervix abnormal 37.79 9.90 58 385990 2316 64110368
Extrapyramidal disorder 37.43 9.90 37 386011 19515 64093169
Oral herpes 37.43 9.90 244 385804 21908 64090776
Tuberculosis 37.34 9.90 166 385882 12872 64099812
Blood glucose increased 37.18 9.90 391 385657 97682 64015002
Influenza 37.11 9.90 867 385181 105664 64007020
Posterior reversible encephalopathy syndrome 36.83 9.90 50 385998 22896 64089788
Spinal stenosis 36.66 9.90 173 385875 13758 64098926
Psychotic disorder 36.47 9.90 97 385951 34481 64078203
Nausea 36.36 9.90 4134 381914 781666 63331018
Suicidal ideation 36.24 9.90 241 385807 66301 64046383
Melaena 36.11 9.90 181 385867 53367 64059317
Drug level increased 36.01 9.90 96 385952 34100 64078584
Status epilepticus 36.00 9.90 46 386002 21617 64091067
Multiple fractures 35.89 9.90 98 385950 5942 64106742
Pulmonary embolism 35.81 9.90 638 385410 145718 63966966
Urticaria 35.79 9.90 643 385405 146674 63966010
Psychomotor hyperactivity 35.77 9.90 21 386027 14430 64098254
Fluid retention 35.50 9.90 210 385838 59396 64053288
Aggression 35.50 9.90 149 385899 46083 64066601
Torsade de pointes 35.43 9.90 31 386017 17332 64095352
Inappropriate antidiuretic hormone secretion 35.34 9.90 49 385999 22240 64090444
Latent tuberculosis 35.26 9.90 61 385987 2696 64109988
Respiratory distress 35.22 9.90 177 385871 52154 64060530
Pulmonary arterial hypertension 35.22 9.90 61 385987 25306 64087378
Product quality issue 35.04 9.90 79 385969 29720 64082964
Bone disorder 34.95 9.90 195 385853 16564 64096120
Ejection fraction decreased 34.66 9.90 75 385973 28632 64084052
Pathogen resistance 34.35 9.90 16 386032 12527 64100157
Neutrophil count decreased 34.27 9.90 296 385752 76900 64035784
Fear of injection 34.21 9.90 95 385953 5817 64106867
Pancytopenia 33.99 9.90 1110 384938 142199 63970485
Arrhythmia 33.99 9.90 182 385866 52762 64059922
Immunodeficiency 33.88 9.90 188 385860 15936 64096748
Therapeutic response decreased 33.61 9.90 468 385580 51720 64060964
Anaphylactic shock 33.59 9.90 83 385965 30245 64082439
Asphyxia 33.51 9.90 8 386040 9558 64103126
Blood creatinine increased 33.50 9.90 591 385457 135191 63977493
Ventricular fibrillation 33.47 9.90 57 385991 23803 64088881
Cardiogenic shock 33.42 9.90 92 385956 32335 64080349
Skin cancer 33.21 9.90 151 385897 11823 64100861
Wheelchair user 33.11 9.90 81 385967 4591 64108093
Drug ineffective for unapproved indication 33.09 9.90 87 385961 31046 64081638
Mouth ulceration 33.05 9.90 318 385730 32126 64080558
Tenosynovitis stenosans 32.78 9.90 49 385999 1911 64110773
Bradyphrenia 32.69 9.90 8 386040 9398 64103286
Aspergillus infection 32.52 9.90 30 386018 16349 64096335
Proteinuria 32.19 9.90 74 385974 27649 64085035
Ear infection 32.06 9.90 245 385803 23159 64089525
Surgery 32.01 9.90 283 385765 27930 64084754
Second primary malignancy 31.88 9.90 17 386031 12320 64100364
No adverse event 31.76 9.90 78 385970 28483 64084201
Gastrointestinal haemorrhage 31.66 9.90 579 385469 131733 63980951
Haematotoxicity 31.56 9.90 19 386029 12877 64099807
Skin papilloma 31.49 9.90 85 385963 5118 64107566
Balance disorder 31.24 9.90 336 385712 83590 64029094
Bronchopulmonary aspergillosis 31.23 9.90 41 386007 19044 64093640
Cerebral infarction 31.07 9.90 133 385915 40911 64071773
Akathisia 31.03 9.90 15 386033 11495 64101189
Atrial fibrillation 30.97 9.90 783 385265 170306 63942378
Emotional distress 30.97 9.90 111 385937 35927 64076757
Ischaemic stroke 30.96 9.90 81 385967 28954 64083730
Cytokine release syndrome 30.86 9.90 48 386000 20781 64091903
Gastroenteritis viral 30.74 9.90 213 385835 19516 64093168
Agranulocytosis 30.74 9.90 121 385927 38108 64074576
Blood cholesterol increased 30.65 9.90 445 385603 49621 64063063
Malignant melanoma 30.55 9.90 156 385892 12808 64099876
Accidental overdose 30.43 9.90 101 385947 33456 64079228
Withdrawal syndrome 30.38 9.90 59 385989 23433 64089251
Injection site warmth 30.34 9.90 160 385888 13302 64099382
Asthma 30.16 9.90 395 385653 94830 64017854
Rash maculo-papular 29.99 9.90 162 385886 46864 64065820
Transplant rejection 29.91 9.90 36 386012 17365 64095319
Joint noise 29.84 9.90 62 385986 3149 64109535
Unintentional medical device removal 29.51 9.90 3 386045 6731 64105953
Vision blurred 29.21 9.90 373 385675 89943 64022741
Acute graft versus host disease 29.19 9.90 9 386039 9075 64103609
Miosis 29.17 9.90 22 386026 13244 64099440
Coronary artery disease 28.98 9.90 227 385821 60206 64052478
Foot fracture 28.87 9.90 197 385851 17960 64094724
Synovial fluid analysis 28.82 9.90 41 386007 1528 64111156
Rotator cuff repair 28.76 9.90 40 386008 1459 64111225
Muscle spasms 28.69 9.90 634 385414 140389 63972295
Shock haemorrhagic 28.59 9.90 35 386013 16756 64095928
Coagulopathy 28.31 9.90 97 385951 31823 64080861
Ascites 28.30 9.90 236 385812 61765 64050919
Mobility decreased 28.19 9.90 693 385355 85147 64027537
Gamma-glutamyltransferase increased 27.79 9.90 173 385875 48337 64064347
Forced expiratory volume decreased 27.78 9.90 4 386044 6863 64105821
Blood parathyroid hormone decreased 27.65 9.90 102 385946 7264 64105420
Intentional product use issue 27.57 9.90 757 385291 94607 64018077
Foetal death 27.40 9.90 88 385960 5842 64106842
Loss of consciousness 27.39 9.90 677 385371 147688 63964996
Hypertransaminasaemia 27.28 9.90 5 386043 7186 64105498
Eosinophilia 27.24 9.90 126 385922 37950 64074734
Maternal exposure timing unspecified 27.21 9.90 54 385994 2653 64110031
Osteonecrosis of jaw 27.20 9.90 134 385914 39691 64072993
Loose body in joint 27.20 9.90 35 386013 1183 64111501
Thrombotic microangiopathy 27.03 9.90 36 386012 16619 64096065
Tachypnoea 26.93 9.90 76 385972 26495 64086189
Ulcer 26.80 9.90 232 385816 22758 64089926
Rhinorrhoea 26.72 9.90 506 385542 59463 64053221
Graft versus host disease 26.60 9.90 26 386022 13787 64098897
Haemoptysis 26.53 9.90 178 385870 48870 64063814
Acute chest syndrome 26.47 9.90 30 386018 886 64111798
Subdural haematoma 26.44 9.90 83 385965 27971 64084713
BK virus infection 26.36 9.90 6 386042 7406 64105278
Dysarthria 26.27 9.90 228 385820 59178 64053506
Pulmonary oedema 26.16 9.90 323 385725 78351 64034333
Respiratory disorder 26.13 9.90 119 385929 35992 64076692
Oxygen saturation decreased 25.89 9.90 832 385216 106344 64006340
Cerebrovascular accident 25.89 9.90 626 385422 136957 63975727
Fear 25.79 9.90 51 385997 20120 64092564
Acute respiratory failure 25.64 9.90 184 385864 49750 64062934
Dystonia 25.61 9.90 46 386002 18819 64093865
Blood alkaline phosphatase increased 25.33 9.90 215 385833 56064 64056620
Chronic kidney disease 25.30 9.90 223 385825 57696 64054988
Granuloma skin 25.27 9.90 87 385961 5987 64106697
Post procedural infection 25.12 9.90 119 385929 9478 64103206
Tumour lysis syndrome 24.99 9.90 49 385999 19391 64093293
Hyperthermia 24.84 9.90 34 386014 15516 64097168
Antinuclear antibody positive 24.69 9.90 88 385960 6162 64106522
Leukocytosis 24.63 9.90 129 385919 37611 64075073
Polyhydramnios 24.62 9.90 37 386011 1450 64111234
Glycosylated haemoglobin increased 24.62 9.90 36 386012 15983 64096701
Haemorrhage 24.45 9.90 331 385717 79020 64033664
Haemorrhage intracranial 24.44 9.90 68 385980 23816 64088868
Dysgeusia 24.33 9.90 173 385875 46874 64065810
Anaphylactic reaction 24.33 9.90 278 385770 68386 64044298
Fracture delayed union 24.19 9.90 43 386005 1942 64110742
Postoperative wound infection 24.09 9.90 124 385924 10212 64102472
Blood bilirubin increased 24.09 9.90 224 385824 57329 64055355
Mania 23.69 9.90 38 386010 16248 64096436
Creatinine renal clearance decreased 23.57 9.90 31 386017 14390 64098294
Drug use disorder 23.42 9.90 4 386044 6050 64106634
Dyskinesia 23.33 9.90 139 385909 39249 64073435
Product administration error 23.19 9.90 86 385962 27557 64085127
Toxic epidermal necrolysis 23.17 9.90 129 385919 37037 64075647
Panniculitis 23.17 9.90 110 385938 8769 64103915
Deep vein thrombosis 23.10 9.90 467 385581 104715 64007969
Acute respiratory distress syndrome 22.75 9.90 138 385910 38797 64073887
Acidosis 22.74 9.90 45 386003 17750 64094934
Scleritis 22.72 9.90 53 385995 2913 64109771
Wrong technique in product usage process 22.65 9.90 264 385784 64710 64047974
Bursitis 22.59 9.90 212 385836 21273 64091411
Acute generalised exanthematous pustulosis 22.19 9.90 31 386017 14027 64098657
Hypomagnesaemia 22.08 9.90 132 385916 37244 64075440
Toxic skin eruption 21.97 9.90 52 385996 19232 64093452
Pleural effusion 21.89 9.90 583 385465 125976 63986708
White blood cell count decreased 21.89 9.90 749 385299 157088 63955596
Adverse event 21.85 9.90 345 385703 39144 64073540
Joint dislocation 21.69 9.90 130 385918 11335 64101349
Acute graft versus host disease in skin 21.65 9.90 7 386041 6848 64105836
Stillbirth 21.64 9.90 59 385989 3574 64109110
Pharyngitis streptococcal 21.62 9.90 106 385942 8562 64104122
Pulmonary alveolar haemorrhage 21.60 9.90 16 386032 9722 64102962
Jaundice 21.54 9.90 186 385862 48326 64064358
Potentiating drug interaction 21.52 9.90 10 386038 7842 64104842
Lipase increased 21.52 9.90 33 386015 14369 64098315
Aphasia 21.36 9.90 150 385898 40756 64071928
Hyperbilirubinaemia 21.23 9.90 61 385987 21144 64091540
Weight decreased 21.22 9.90 1986 384062 283753 63828931
Dactylitis 21.12 9.90 40 386008 1898 64110786
Graft versus host disease in gastrointestinal tract 21.08 9.90 4 386044 5608 64107076
Vertigo 20.87 9.90 239 385809 58772 64053912
Stress cardiomyopathy 20.81 9.90 15 386033 9242 64103442
Hepatic encephalopathy 20.80 9.90 61 385987 21005 64091679
Dyspnoea exertional 20.80 9.90 313 385735 73417 64039267
Synovial disorder 20.79 9.90 27 386021 921 64111763
Respiration abnormal 20.76 9.90 6 386042 6309 64106375
Depression 20.75 9.90 891 385157 182400 63930284
Endodontic procedure 20.59 9.90 44 386004 2279 64110405
Hallucination, visual 20.58 9.90 91 385957 27743 64084941
Pulmonary tuberculosis 20.57 9.90 92 385956 7152 64105532
Cyanosis 20.56 9.90 66 385982 22089 64090595
Pancreatitis 20.47 9.90 243 385805 59364 64053320
Breast feeding 20.44 9.90 23 386025 674 64112010
Normal newborn 20.43 9.90 77 385971 5540 64107144
Haemoglobin decreased 20.38 9.90 1392 384656 193671 63919013
Cardiac failure acute 20.32 9.90 42 386006 16302 64096382
Lupus-like syndrome 20.17 9.90 105 385943 8686 64103998
Clostridium difficile colitis 20.12 9.90 89 385959 27134 64085550
Platelet count decreased 20.10 9.90 810 385238 166901 63945783
Polyneuropathy 20.09 9.90 57 385991 19837 64092847
Exposure to toxic agent 19.97 9.90 6 386042 6153 64106531
Hyperammonaemia 19.83 9.90 18 386030 9886 64102798
Endophthalmitis 19.78 9.90 4 386044 5361 64107323
Device use error 19.76 9.90 7 386041 6464 64106220
Cushingoid 19.70 9.90 94 385954 7509 64105175
Febrile bone marrow aplasia 19.65 9.90 23 386025 11232 64101452
Haemophagocytic lymphohistiocytosis 19.65 9.90 48 386000 17561 64095123
Rebound effect 19.58 9.90 3 386045 4914 64107770
Pleuritic pain 19.48 9.90 98 385950 7998 64104686
Dry eye 19.40 9.90 262 385786 28757 64083927
Exostosis 19.33 9.90 126 385922 11312 64101372
Muscle rigidity 19.21 9.90 48 386000 17425 64095259
Pneumatosis intestinalis 19.07 9.90 4 386044 5225 64107459
Human antichimeric antibody positive 18.99 9.90 32 386016 1384 64111300
Anhedonia 18.99 9.90 33 386015 13673 64099011
Sepsis 18.93 9.90 1157 384891 229184 63883500
Face oedema 18.89 9.90 80 385968 24681 64088003
Sinus tachycardia 18.85 9.90 114 385934 32074 64080610
Foetal distress syndrome 18.82 9.90 18 386030 434 64112250
Pyrexia 18.79 9.90 2997 383051 555647 63557037
Nocardiosis 18.78 9.90 3 386045 4764 64107920
Delusion 18.64 9.90 51 385997 17963 64094721
Haemorrhage in pregnancy 18.61 9.90 30 386018 1250 64111434
Nightmare 18.48 9.90 64 385984 20929 64091755
Tooth infection 18.43 9.90 150 385898 14451 64098233
Induced labour 18.41 9.90 24 386024 822 64111862
Klebsiella infection 18.38 9.90 32 386016 13249 64099435
Labelled drug-drug interaction medication error 18.27 9.90 69 385979 21993 64090691
Hallucination, auditory 18.26 9.90 47 386001 16892 64095792
Mass 18.25 9.90 155 385893 15121 64097563
Chest discomfort 18.25 9.90 542 385506 115564 63997120
Ingrown hair 18.16 9.90 20 386028 572 64112112
Cellulitis 18.14 9.90 709 385339 92948 64019736
Chest pain 18.07 9.90 1193 384855 234787 63877897
Tardive dyskinesia 18.00 9.90 17 386031 9161 64103523
Colitis ulcerative 17.99 9.90 214 385834 22814 64089870
Cytomegalovirus viraemia 17.99 9.90 23 386025 10805 64101879
Incorrect route of product administration 17.94 9.90 75 385973 23223 64089461
Polyuria 17.92 9.90 30 386018 12613 64100071
Drug hypersensitivity 17.92 9.90 1204 384844 236611 63876073
Aspartate aminotransferase increased 17.89 9.90 563 385485 119225 63993459
Placental disorder 17.88 9.90 24 386024 846 64111838
Dislocation of vertebra 17.88 9.90 50 385998 3074 64109610
Haematocrit decreased 17.87 9.90 441 385607 54214 64058470
Spinal disorder 17.86 9.90 101 385947 8621 64104063
Progressive multifocal leukoencephalopathy 17.85 9.90 53 385995 18179 64094505
Stevens-Johnson syndrome 17.68 9.90 126 385922 34123 64078561
Cyst 17.66 9.90 128 385920 11899 64100785
Hyperuricaemia 17.61 9.90 21 386027 10170 64102514
Lacrimal disorder 17.56 9.90 18 386030 473 64112211
Metastases to bone 17.52 9.90 63 385985 20372 64092312
Musculoskeletal disorder 17.50 9.90 174 385874 17732 64094952
Cardiomyopathy 17.50 9.90 85 385963 25271 64087413
Frequent bowel movements 17.47 9.90 177 385871 18128 64094556
Pancreatitis acute 17.42 9.90 168 385880 42687 64069997
Cytopenia 17.40 9.90 42 386006 15429 64097255
Muscle spasticity 17.40 9.90 47 386001 16622 64096062
Pemphigoid 17.33 9.90 32 386016 12954 64099730
Adenovirus infection 17.32 9.90 11 386037 7244 64105440
Heart rate irregular 17.31 9.90 245 385803 27168 64085516
Upper respiratory tract infection 17.31 9.90 564 385484 72221 64040463
Off label use 17.30 9.90 3433 382615 629373 63483311
Acute myeloid leukaemia 17.30 9.90 95 385953 27368 64085316
Chronic graft versus host disease 17.19 9.90 8 386040 6268 64106416
Hyperlactacidaemia 17.07 9.90 4 386044 4840 64107844
Sciatica 17.03 9.90 191 385857 20073 64092611
Injection site urticaria 17.00 9.90 120 385928 11061 64101623
Angina pectoris 16.97 9.90 180 385868 44901 64067783
Acute coronary syndrome 16.91 9.90 59 385989 19251 64093433
Pain in jaw 16.89 9.90 159 385889 40596 64072088
Arthritis bacterial 16.87 9.90 92 385956 7747 64104937
Body height below normal 16.77 9.90 35 386013 1783 64110901
Bone density abnormal 16.77 9.90 45 386003 2700 64109984
Bone pain 16.69 9.90 193 385855 47379 64065305
Polydipsia 16.61 9.90 7 386041 5814 64106870
Sexual dysfunction 16.60 9.90 9 386039 6462 64106222
Hemiplegia 16.57 9.90 32 386016 12736 64099948
Blood pressure decreased 16.54 9.90 391 385657 85808 64026876
Maternal exposure during breast feeding 16.53 9.90 37 386011 1979 64110705
Cystitis haemorrhagic 16.48 9.90 14 386034 7942 64104742
Pulseless electrical activity 16.47 9.90 32 386016 12707 64099977
Epstein-Barr virus infection 16.47 9.90 31 386017 12457 64100227
Gastric haemorrhage 16.46 9.90 35 386013 13446 64099238
Drug-induced liver injury 16.44 9.90 194 385854 47449 64065235
Flushing 16.44 9.90 352 385696 78296 64034388
Insomnia 16.38 9.90 993 385055 196843 63915841
Tooth abscess 16.37 9.90 140 385908 13686 64098998
Urinary retention 16.35 9.90 202 385846 48999 64063685
Placental insufficiency 16.35 9.90 25 386023 995 64111689
Pulmonary hypertension 16.34 9.90 172 385876 42967 64069717
Antibody test positive 16.29 9.90 41 386007 2366 64110318
Gestational hypertension 16.26 9.90 33 386015 1648 64111036
Sinus bradycardia 16.23 9.90 76 385972 22817 64089867
Peripheral sensory neuropathy 16.12 9.90 27 386021 11351 64101333
Device difficult to use 16.08 9.90 21 386027 9777 64102907
Oliguria 16.05 9.90 40 386008 14536 64098148
Electrocardiogram QRS complex prolonged 16.02 9.90 19 386029 9225 64103459
Coronary arterial stent insertion 15.99 9.90 7 386041 5685 64106999
Metastases to lung 15.96 9.90 43 386005 15221 64097463
Wound infection pseudomonas 15.92 9.90 31 386017 1502 64111182
Obstructive airways disorder 15.84 9.90 78 385970 23107 64089577
Toothache 15.80 9.90 167 385881 17292 64095392
Therapy non-responder 15.76 9.90 511 385537 65388 64047296
Hypophosphataemia 15.74 9.90 41 386007 14679 64098005
Renal injury 15.73 9.90 44 386004 15385 64097299
Lymphatic fistula 15.72 9.90 21 386027 737 64111947
Cystitis 15.69 9.90 350 385698 42325 64070359
Atrioventricular block 15.69 9.90 30 386018 11985 64100699
Nephropathy toxic 15.68 9.90 53 385995 17461 64095223
Femoral hernia incarcerated 15.65 9.90 21 386027 740 64111944
Immunosuppression 15.57 9.90 114 385934 10632 64102052
Atrioventricular block complete 15.54 9.90 40 386008 14378 64098306
Tuberculin test positive 15.54 9.90 47 386001 3021 64109663
Type 2 diabetes mellitus 15.48 9.90 288 385760 33732 64078952
Hypoalbuminaemia 15.48 9.90 54 385994 17620 64095064
Visual acuity reduced 15.44 9.90 97 385951 27044 64085640
Bronchospasm 15.36 9.90 72 385976 21610 64091074
Pharyngitis 15.35 9.90 178 385870 18861 64093823
Injection site haemorrhage 15.34 9.90 217 385831 24061 64088623
Tubulointerstitial nephritis 15.33 9.90 115 385933 30794 64081890
Wound infection 15.29 9.90 146 385902 14718 64097966
Tooth disorder 15.28 9.90 203 385845 22199 64090485
Disease recurrence 15.27 9.90 118 385930 31392 64081292
Alcohol abuse 15.25 9.90 5 386043 4847 64107837
Anger 15.24 9.90 46 386002 15695 64096989
Dysphagia 15.24 9.90 505 385543 106307 64006377
Cardiac failure chronic 15.23 9.90 19 386029 9022 64103662
Arthropod bite 15.23 9.90 80 385968 6641 64106043
Cervical incompetence 15.19 9.90 17 386031 495 64112189
Hypervolaemia 15.18 9.90 151 385897 38134 64074550
Toxic encephalopathy 15.14 9.90 22 386026 9793 64102891
Labyrinthitis 15.03 9.90 42 386006 2581 64110103
Dermatitis acneiform 15.02 9.90 17 386031 8426 64104258
Joint lock 14.93 9.90 44 386004 2787 64109897
Kidney infection 14.93 9.90 168 385880 17670 64095014
Injection site extravasation 14.86 9.90 91 385957 7995 64104689
Myopathy 14.83 9.90 55 385993 17625 64095059
Iodine allergy 14.76 9.90 17 386031 511 64112173
Palpitations 14.67 9.90 495 385553 103993 64008691
Clear cell renal cell carcinoma 14.62 9.90 37 386011 2142 64110542
Malignant mediastinal neoplasm 14.61 9.90 17 386031 517 64112167
Sickle cell anaemia 14.56 9.90 18 386030 584 64112100
Abortion threatened 14.52 9.90 15 386033 398 64112286
Rheumatoid lung 14.51 9.90 40 386008 2439 64110245
Blood lactic acid increased 14.45 9.90 25 386023 10376 64102308
Metastases to liver 14.44 9.90 84 385964 23857 64088827
Aphthous ulcer 14.40 9.90 129 385919 12777 64099907
Affective disorder 14.36 9.90 11 386037 6569 64106115
Eye infection 14.34 9.90 100 385948 9181 64103503
Injection site discolouration 14.34 9.90 80 385968 6795 64105889
Hepatitis fulminant 14.32 9.90 10 386038 6264 64106420
Hemiparesis 14.31 9.90 112 385936 29715 64082969
Acute myocardial infarction 14.29 9.90 313 385735 69405 64043279
Ankle arthroplasty 14.23 9.90 22 386026 884 64111800
Haematoma 14.22 9.90 193 385855 46057 64066627
Muscle twitching 14.11 9.90 62 385986 18936 64093748
Product prescribing error 14.02 9.90 139 385909 35130 64077554
Feeling abnormal 13.98 9.90 655 385393 132947 63979737
Red blood cell count decreased 13.95 9.90 384 385664 48002 64064682
Joint warmth 13.94 9.90 28 386020 1388 64111296
Cholestasis of pregnancy 13.89 9.90 22 386026 903 64111781
Temperature regulation disorder 13.84 9.90 4 386044 4207 64108477
End stage renal disease 13.81 9.90 26 386022 10449 64102235
Knee operation 13.80 9.90 59 385989 4498 64108186
Small for dates baby 13.76 9.90 15 386033 424 64112260
Adjustment disorder with depressed mood 13.74 9.90 39 386009 2418 64110266
Transaminases increased 13.74 9.90 186 385862 44408 64068276
Anal fistula 13.65 9.90 65 385983 5188 64107496
Drug abuser 13.60 9.90 9 386039 5799 64106885
Coordination abnormal 13.59 9.90 45 386003 14919 64097765
Foetal exposure during pregnancy 13.59 9.90 58 385990 4418 64108266
Plasma cell myeloma 13.55 9.90 194 385854 45881 64066803
Bradypnoea 13.49 9.90 7 386041 5152 64107532
Human anti-human antibody test 13.47 9.90 14 386034 374 64112310
Palindromic rheumatism 13.47 9.90 13 386035 317 64112367
Drug specific antibody 13.47 9.90 35 386013 2060 64110624
Breast abscess 13.42 9.90 24 386024 1089 64111595
Anuria 13.42 9.90 63 385985 18901 64093783
Paralysis 13.42 9.90 31 386017 11564 64101120
Tendon disorder 13.42 9.90 74 385974 6258 64106426
Respiratory acidosis 13.41 9.90 24 386024 9831 64102853
Finger deformity 13.35 9.90 64 385984 5122 64107562
Lung transplant 13.33 9.90 4 386044 4104 64108580
Drug screen positive 13.25 9.90 9 386039 5720 64106964
Presyncope 13.25 9.90 140 385908 34949 64077735
Pulmonary congestion 13.25 9.90 86 385962 23794 64088890
C-reactive protein decreased 13.24 9.90 35 386013 2081 64110603
Pneumothorax 13.23 9.90 88 385960 24210 64088474
Metastases to central nervous system 13.22 9.90 41 386007 13871 64098813
Hypercapnia 13.14 9.90 16 386032 7678 64105006
Erythema multiforme 13.07 9.90 49 385999 15652 64097032
Oesophageal fibrosis 13.07 9.90 10 386038 176 64112508
Hepatitis acute 13.05 9.90 39 386009 13350 64099334
Bradykinesia 13.04 9.90 12 386036 6548 64106136
Hernia 13.04 9.90 131 385917 13387 64099297
Dyslipidaemia 13.03 9.90 22 386026 9220 64103464
Incoherent 13.02 9.90 14 386034 7104 64105580
Delivery 12.99 9.90 16 386032 517 64112167
Nephrolithiasis 12.97 9.90 348 385700 43335 64069349
Foot operation 12.95 9.90 55 385993 4180 64108504
Pulmonary haemorrhage 12.91 9.90 38 386010 13071 64099613
Hepatitis cholestatic 12.89 9.90 34 386014 12121 64100563
Chondropathy 12.86 9.90 37 386011 2312 64110372
Catatonia 12.85 9.90 16 386032 7604 64105080
Ileus paralytic 12.85 9.90 19 386029 8396 64104288
Osteoporotic fracture 12.82 9.90 49 385999 3549 64109135
Taste disorder 12.81 9.90 23 386025 9410 64103274
Interstitial lung disease 12.80 9.90 467 385581 97265 64015419
Stress at work 12.80 9.90 22 386026 967 64111717
Mean cell volume increased 12.80 9.90 62 385986 4984 64107700
Memory impairment 12.72 9.90 403 385645 85279 64027405
Lip swelling 12.58 9.90 126 385922 31781 64080903
Myofascial pain syndrome 12.56 9.90 31 386017 1767 64110917
Retinitis 12.56 9.90 34 386014 2051 64110633
Blood folate increased 12.54 9.90 15 386033 470 64112214
Therapeutic product effect incomplete 12.54 9.90 748 385300 102734 64009950
Abortion missed 12.54 9.90 24 386024 1148 64111536
Intracranial pressure increased 12.51 9.90 14 386034 6975 64105709
Pancreatic steatosis 12.50 9.90 22 386026 986 64111698
Transplant dysfunction 12.49 9.90 13 386035 6695 64105989
Bacteraemia 12.48 9.90 102 385946 26809 64085875
Cholangitis 12.41 9.90 29 386019 10773 64101911
Purpura 12.38 9.90 57 385991 17189 64095495
Serum ferritin increased 12.36 9.90 90 385958 8378 64104306
Postpartum haemorrhage 12.36 9.90 27 386021 1420 64111264
Cytomegalovirus chorioretinitis 12.36 9.90 7 386041 4905 64107779
Skin ulcer haemorrhage 12.32 9.90 15 386033 479 64112205
Hepatitis C 12.31 9.90 30 386018 10985 64101699
Skin laceration 12.28 9.90 210 385838 24207 64088477
Threatened labour 12.25 9.90 16 386032 549 64112135
Hypocalcaemia 12.21 9.90 176 385872 41577 64071107
Increased tendency to bruise 12.18 9.90 96 385952 9159 64103525
Erectile dysfunction 12.15 9.90 37 386011 12590 64100094
Myelosuppression 12.14 9.90 88 385960 23742 64088942
Heparin-induced thrombocytopenia 12.13 9.90 20 386028 8459 64104225
Colitis microscopic 12.12 9.90 16 386032 7416 64105268
Peritoneal dialysis complication 12.11 9.90 35 386013 2193 64110491
Ileus 12.09 9.90 84 385964 22882 64089802
Right ventricular failure 12.08 9.90 77 385971 21394 64091290
Unevaluable event 12.05 9.90 221 385827 50268 64062416
Schizophrenia 12.03 9.90 31 386017 11137 64101547
Generalised tonic-clonic seizure 12.01 9.90 167 385881 39690 64072994
Osteopenia 11.96 9.90 144 385904 15396 64097288
Virologic failure 11.95 9.90 3 386045 3463 64109221
Hyperthyroidism 11.94 9.90 62 385986 18117 64094567
Sudden death 11.86 9.90 71 385977 20025 64092659
Hepatocellular carcinoma 11.85 9.90 20 386028 8383 64104301
Skin neoplasm excision 11.85 9.90 20 386028 866 64111818
Myocarditis 11.84 9.90 57 385991 16986 64095698
Hospitalisation 11.83 9.90 351 385697 74856 64037828
Septic shock 11.83 9.90 513 385535 104924 64007760
Lip blister 11.81 9.90 35 386013 2224 64110460
Blood loss anaemia 11.80 9.90 43 386005 13849 64098835
Blood calcium decreased 11.78 9.90 97 385951 25457 64087227
Myocardial ischaemia 11.78 9.90 86 385962 23165 64089519
Eosinophil count increased 11.77 9.90 44 386004 14068 64098616
Lymphocyte count decreased 11.74 9.90 172 385876 40527 64072157
Ankylosing spondylitis 11.73 9.90 87 385961 8147 64104537
Skin necrosis 11.56 9.90 134 385914 14195 64098489
Spinal osteoarthritis 11.52 9.90 134 385914 14207 64098477
Oligohydramnios 11.51 9.90 43 386005 3081 64109603
Bundle branch block left 11.47 9.90 27 386021 10007 64102677
Cardiotoxicity 11.47 9.90 28 386020 10246 64102438
Complication of device insertion 11.43 9.90 8 386040 5004 64107680
Accidental death 11.42 9.90 4 386044 3721 64108963
Skin infection 11.42 9.90 139 385909 14898 64097786
Sinus congestion 11.42 9.90 142 385906 15297 64097387
Abdominal distension 11.41 9.90 464 385584 95530 64017154
Catheter management 11.38 9.90 3 386045 3352 64109332
Vacuum extractor delivery 11.37 9.90 8 386040 123 64112561
Device leakage 11.36 9.90 20 386028 8246 64104438
Skin graft failure 11.36 9.90 10 386038 216 64112468
Swollen joint count 11.33 9.90 16 386032 592 64112092
Prostatic specific antigen increased 11.33 9.90 22 386026 8738 64103946
Mesothelioma 11.27 9.90 12 386036 330 64112354
Nail injury 11.21 9.90 14 386034 459 64112225
Pneumonia bacterial 11.21 9.90 49 385999 14986 64097698
Uterine perforation 11.16 9.90 11 386037 5809 64106875
Radiation inflammation 11.13 9.90 10 386038 222 64112462
Amylase increased 11.12 9.90 26 386022 9659 64103025
Cataract 11.12 9.90 393 385655 50869 64061815
Lower respiratory tract congestion 11.11 9.90 41 386007 2920 64109764
Glomerular filtration rate decreased 11.10 9.90 70 385978 19502 64093182
Genital haemorrhage 11.10 9.90 10 386038 5512 64107172
Ventricular arrhythmia 11.07 9.90 17 386031 7398 64105286
Hypoxic-ischaemic encephalopathy 11.06 9.90 16 386032 7136 64105548
Carpal tunnel syndrome 11.04 9.90 144 385904 15684 64097000
Gastroenteritis 11.02 9.90 244 385804 29467 64083217
Medical device site joint infection 11.02 9.90 10 386038 225 64112459
Enterocolitis 11.01 9.90 36 386012 11982 64100702
Intestinal ischaemia 11.00 9.90 34 386014 11515 64101169
Inflammatory bowel disease 10.97 9.90 55 385993 4483 64108201
Brain natriuretic peptide increased 10.92 9.90 18 386030 7615 64105069
Pancreatic duct stenosis 10.88 9.90 10 386038 229 64112455
Speech disorder developmental 10.85 9.90 15 386033 544 64112140
Crying 10.82 9.90 73 385975 20017 64092667
Benign ovarian tumour 10.80 9.90 11 386037 287 64112397
Haemodialysis 10.79 9.90 59 385989 17018 64095666
Hydrocephalus 10.77 9.90 18 386030 7573 64105111
Failed induction of labour 10.77 9.90 10 386038 232 64112452
Sensitivity to weather change 10.76 9.90 73 385975 6641 64106043
Nephrotic syndrome 10.74 9.90 26 386022 9541 64103143
Diabetes mellitus inadequate control 10.73 9.90 79 385969 21242 64091442
Type 1 diabetes mellitus 10.69 9.90 11 386037 5694 64106990
Hypotonia 10.69 9.90 33 386015 11179 64101505
Hypertriglyceridaemia 10.67 9.90 33 386015 11172 64101512
Paranoia 10.61 9.90 56 385992 16296 64096388
Alanine aminotransferase increased 10.61 9.90 703 385345 138328 63974356
Hyperhomocysteinaemia 10.60 9.90 13 386035 418 64112266
Vascular insufficiency 10.59 9.90 14 386034 486 64112198
Drug tolerance decreased 10.58 9.90 75 385973 6923 64105761
Kidney transplant rejection 10.55 9.90 26 386022 9485 64103199
Vascular rupture 10.54 9.90 24 386024 1298 64111386
Hiatus hernia 10.53 9.90 173 385875 19784 64092900
COVID-19 pneumonia 10.44 9.90 57 385991 16447 64096237
Troponin increased 10.41 9.90 52 385996 15347 64097337
Lethargy 10.40 9.90 343 385705 72251 64040433
Hernia pain 10.39 9.90 13 386035 427 64112257
Diaphragmatic disorder 10.38 9.90 25 386023 1403 64111281
Panic attack 10.37 9.90 78 385970 20875 64091809
Decreased insulin requirement 10.35 9.90 8 386040 143 64112541
Cartilage injury 10.34 9.90 24 386024 1315 64111369
Aspiration 10.31 9.90 59 385989 16826 64095858
Photophobia 10.30 9.90 153 385895 17140 64095544
Haemodynamic instability 10.28 9.90 50 385998 14862 64097822
Hyperlipidaemia 10.24 9.90 88 385960 22888 64089796
Haematemesis 10.22 9.90 209 385839 46790 64065894
Peripheral venous disease 10.21 9.90 69 385979 6269 64106415
Mental disorder 10.19 9.90 105 385943 26340 64086344
Complication of pregnancy 10.17 9.90 11 386037 308 64112376
Hypernatraemia 10.17 9.90 38 386010 12151 64100533
Generalised oedema 10.15 9.90 78 385970 20775 64091909
Neck pain 10.14 9.90 458 385590 61075 64051609
Pseudomonas infection 10.12 9.90 64 385984 17819 64094865
Musculoskeletal discomfort 10.09 9.90 145 385903 16132 64096552
Device related infection 10.08 9.90 126 385922 30500 64082184
Alcohol interaction 10.07 9.90 7 386041 4394 64108290
Laryngospasm 10.06 9.90 4 386044 3441 64109243
Thiopurine methyltransferase decreased 10.06 9.90 11 386037 312 64112372
Mental impairment 10.04 9.90 57 385991 16286 64096398
Intestinal stenosis 10.03 9.90 42 386006 3172 64109512
Mycobacterium tuberculosis complex test positive 10.03 9.90 31 386017 2016 64110668
Coronary artery bypass 10.03 9.90 12 386036 5803 64106881
Renal disorder 10.02 9.90 150 385898 35215 64077469
Impaired work ability 10.01 9.90 137 385911 15082 64097602
Ketoacidosis 9.99 9.90 16 386032 6847 64105837
Tooth fracture 9.96 9.90 97 385951 9830 64102854
Salivary hypersecretion 9.95 9.90 38 386010 12075 64100609
Dementia 9.95 9.90 78 385970 20688 64091996
Left ventricular dysfunction 9.95 9.90 60 385988 16894 64095790
Lung neoplasm malignant 9.91 9.90 182 385866 21266 64091418

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Proctitis indication 3951002 DOID:3127
Tinea pedis indication 6020002 DOID:12403
Wound indication 13924000
Burn injury indication 48333001
Candidiasis of skin indication 49883006
Pityriasis versicolor indication 56454009 DOID:9060
Hemorrhoids indication 70153002 DOID:9746
Rectal pain indication 77880009
Tinea corporis indication 84849002
Pruritus ani indication 90446007
Diaper rash indication 91487003
Eruption of skin indication 271807003 DOID:0050486
Skin irritation indication 367466007
Tinea cruris indication 399029005
Arthropod bite wound indication 409985002
Itching of skin indication 418363000
Minor Bacterial Skin Infections indication
Paronychia off-label use 71906005 DOID:13117
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Anxiety contraindication 48694002
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Open wound contraindication 125643001
Hb SS disease contraindication 127040003 DOID:10923
Benign prostatic hyperplasia contraindication 266569009
Hemochromatosis contraindication 399187006 DOID:2352
Disorder of coronary artery contraindication 414024009
Denuded skin contraindication 418242004
Nervousness contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.25%;81.35%;15% VUSION MYLAN N021026 Feb. 16, 2006 RX OINTMENT TOPICAL 8147852 March 30, 2028 USE FOR TREATMENT OF DIAPER DERMATITIS COMPLICATED BY CANDIDIASIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
SOI2LOH54Z UNII
4019034 VUID
N0000147305 NUI
D01170 KEGG_DRUG
4017643 VANDF
4019034 VANDF
4019036 VANDF
C0043491 UMLSCUI
CHEBI:36560 CHEBI
CHEMBL3988900 ChEMBL_ID
14806 PUBCHEM_CID
DB09321 DRUGBANK_ID
D015034 MESH_DESCRIPTOR_UI
11423 RXNORM
5049 MMSL
5709 MMSL
001922 NDDF
398971002 SNOMEDCT_US
42841002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 80 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 80 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 10 mg TOPICAL OTC monograph not final 8 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 60 mg TOPICAL OTC monograph not final 8 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5703 LOTION 60 mg TOPICAL OTC monograph not final 7 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5738 LOTION 120 mg TOPICAL OTC monograph not final 8 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 1 TOPICAL OTC monograph final 8 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0194 PASTE 40 g TOPICAL OTC monograph final 11 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0323 CREAM 40 g TOPICAL OTC MONOGRAPH FINAL 12 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0324 OINTMENT 16 g TOPICAL OTC MONOGRAPH FINAL 12 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0333 CREAM 16 g TOPICAL OTC monograph final 11 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0334 CREAM 16 g TOPICAL OTC monograph final 11 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0557 CREAM 16 g TOPICAL export only 11 sections
Selan Plus Zinc Oxide HUMAN OTC DRUG LABEL 2 0159-2200 CREAM 2 g TOPICAL OTC monograph final 11 sections
CALENDULA DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2189 CREAM 12 g TOPICAL OTC monograph final 8 sections
WHITE MALLOW DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2207 CREAM 14 g TOPICAL OTC monograph final 8 sections
ZINC OXIDE HUMAN OTC DRUG LABEL 1 0168-0062 OINTMENT 200 mg TOPICAL OTC monograph final 9 sections
Dr. Smiths Rash and Skin HUMAN OTC DRUG LABEL 1 0178-0370 OINTMENT 10 g TOPICAL OTC monograph not final 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 25 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 25 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 25 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 25 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 25 mg ORAL Unapproved drug other 11 sections
Caladryl HUMAN OTC DRUG LABEL 3 0187-5465 LOTION 78.65 mg TOPICAL OTC monograph final 14 sections
Calcemin Advance HUMAN OTC DRUG LABEL 5 0280-0272 TABLET, FILM COATED 7.50 mg ORAL Export only 2 sections
Calcemin Silver HUMAN OTC DRUG LABEL 3 0280-0273 TABLET, FILM COATED 7.50 mg ORAL Export only 2 sections
Cetaphil Sheer Mineral Sunscreen Stick SPF 50 HUMAN OTC DRUG LABEL 2 0299-4108 STICK 47 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Face Liquid Sunscreen SPF 50 HUMAN OTC DRUG LABEL 1 0299-4110 LOTION 120 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Face Liquid Sunscreen SPF 50 HUMAN OTC DRUG LABEL 1 0299-4110 LOTION 120 mg TOPICAL OTC monograph final 11 sections