zinc oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4240	1314-13-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: zinc oxide	A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock. Molecular weight: 81.38 Formula: OZn CLOGP: -1.12 LIPINSKI: None HAC: 1 HDO: 0 TPSA: 17.07 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

zinc oxide

A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.

Molecular weight: 81.38
Formula: OZn
CLOGP: -1.12
LIPINSKI: None
HAC: 1
HDO: 0
TPSA: 17.07
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 16, 2006	FDA	DELCOR ASSET

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	1968.21	10.36	4403	492982	179323	62812314
Systemic lupus erythematosus	1863.95	10.36	4662	492723	204256	62787381
Glossodynia	1645.97	10.36	4040	493345	174836	62816801
Hand deformity	1355.02	10.36	3495	493890	155962	62835675
Arthropathy	1314.39	10.36	4435	492950	230357	62761280
Alopecia	1134.28	10.36	5437	491948	332099	62659538
Abdominal discomfort	1130.90	10.36	5241	492144	315644	62675993
Wound	1123.36	10.36	3313	494072	159950	62831687
Rheumatoid arthritis	1032.85	10.36	4329	493056	249490	62742147
Maternal exposure during pregnancy	1016.57	10.36	3905	493480	216157	62775480

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	613.34	10.28	823	162686	37415	34756007
Drug abuse	328.53	10.28	39	163470	99057	34694365
Foetal exposure during pregnancy	315.68	10.28	607	162902	37494	34755928
Toxicity to various agents	271.27	10.28	323	163186	200039	34593383
Arthralgia	252.37	10.28	1506	162003	168535	34624887
Completed suicide	236.35	10.28	82	163427	98086	34695336
Psoriatic arthropathy	200.23	10.28	344	163165	19454	34773968
Sickle cell anaemia with crisis	154.94	10.28	138	163371	3915	34789507
Joint swelling	144.39	10.28	609	162900	59281	34734141
Dysmorphism	140.00	10.28	117	163392	3039	34790383

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	1383.30	9.72	3629	497644	204841	79038274
Arthropathy	1106.65	9.72	3016	498257	174095	79069020
Completed suicide	1068.31	9.72	141	501132	245626	78997489
Joint swelling	1065.34	9.72	4104	497169	284542	78958573
Pemphigus	1062.69	9.72	2094	499179	97488	79145627
Systemic lupus erythematosus	1060.97	9.72	2349	498924	118800	79124315
Hand deformity	1033.49	9.72	2122	499151	101797	79141318
Synovitis	1024.84	9.72	2649	498624	148085	79095030
Toxicity to various agents	939.20	9.72	764	500509	420776	78822339
Glossodynia	925.49	9.72	2022	499251	101315	79141800

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Proctitis	indication	3951002	DOID:3127
Tinea pedis	indication	6020002	DOID:12403
Wound	indication	13924000
Burn injury	indication	48333001
Candidiasis of skin	indication	49883006
Pityriasis versicolor	indication	56454009	DOID:9060
Hemorrhoids	indication	70153002	DOID:9746
Rectal pain	indication	77880009
Tinea corporis	indication	84849002
Pruritus ani	indication	90446007

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

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Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.25%;81.35%;15%	VUSION	MYLAN	N021026	Feb. 16, 2006	RX	OINTMENT	TOPICAL	8147852	March 30, 2028	USE FOR TREATMENT OF DIAPER DERMATITIS COMPLICATED BY CANDIDIASIS

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Orange Book exclusivity data (new drug applications)

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Bioactivity Summary:

None

External reference:

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ID	Source
001922	NDDF
11423	RXNORM
14806	PUBCHEM_CID
398971002	SNOMEDCT_US
4017643	VANDF
4019034	VUID
4019034	VANDF
4019036	VANDF
42841002	SNOMEDCT_US
5049	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0194	PASTE	40 g	TOPICAL	OTC monograph final	11 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0323	CREAM	40 g	TOPICAL	OTC MONOGRAPH FINAL	12 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0324	OINTMENT	16 g	TOPICAL	OTC MONOGRAPH FINAL	12 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0333	CREAM	16 g	TOPICAL	OTC monograph final	11 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0334	CREAM	16 g	TOPICAL	OTC monograph final	11 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0557	CREAM	16 g	TOPICAL	export only	11 sections
CALENDULA DIAPER RASH CREAM	HUMAN OTC DRUG LABEL	1	0164-2189	CREAM	12 g	TOPICAL	OTC monograph final	8 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	25 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	25 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN OTC DRUG LABEL	14	0178-0829	TABLET	25 mg	ORAL	Unapproved drug other	11 sections

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