isopropanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4215 67-63-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isopropyl alcohol
  • 2-Propanol
  • iso-Propanol
  • isopropanol
An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
  • Molecular weight: 60.10
  • Formula: C3H8O
  • CLOGP: 0.07
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: 0.80
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,MAP2K6,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK 38
kinase-selectivity-class IRAK3,PDK2 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 4234.10 24.90 2821 156571 142237 90326818
Toxicity to various agents 1771.49 24.90 2348 157044 285498 90183557
Drug abuse 1382.86 24.90 1151 158241 81196 90387859
Irritable bowel syndrome 673.99 24.90 1264 158128 206184 90262871
Cardio-respiratory arrest 666.14 24.90 681 158711 62459 90406596
Folliculitis 658.73 24.90 1241 158151 203112 90265943
Injury 602.21 24.90 1171 158221 196178 90272877
Muscle injury 600.82 24.90 1098 158294 175556 90293499
Helicobacter infection 598.39 24.90 1267 158125 225583 90243472
Ill-defined disorder 589.81 24.90 1118 158274 183773 90285282
Impaired healing 559.60 24.90 1257 158135 232942 90236113
Rheumatic fever 514.57 24.90 947 158445 152174 90316881
Cough 512.90 24.90 35 159357 368927 90100128
Duodenal ulcer perforation 510.03 24.90 1171 158221 220117 90248938
Drug ineffective 492.52 24.90 1068 158324 1383230 89085825
Anaemia 471.88 24.90 40 159352 352762 90116293
Type 2 diabetes mellitus 468.83 24.90 1076 158316 202168 90266887
Sleep disorder 456.33 24.90 1048 158344 196982 90272073
Joint range of motion decreased 455.81 24.90 839 158553 134804 90334251
Alcohol interaction 443.56 24.90 152 159240 1602 90467453
Pericarditis 442.02 24.90 1256 158136 268895 90200160
Liver injury 425.76 24.90 932 158460 169635 90299420
Intentional overdose 424.81 24.90 663 158729 93171 90375884
Urinary tract infection 413.24 24.90 33 159359 305599 90163456
Hand deformity 408.50 24.90 1297 158095 295065 90173990
Product dose omission issue 407.25 24.90 27 159365 291660 90177395
Suspected suicide 398.93 24.90 234 159158 9334 90459721
Sleep disorder due to general medical condition, insomnia type 398.80 24.90 769 158623 127925 90341130
Swollen joint count increased 392.79 24.90 703 158689 110503 90358552
Constipation 371.57 24.90 33 159359 280362 90188693
Hypercholesterolaemia 364.28 24.90 644 158748 100248 90368807
Adjustment disorder with depressed mood 360.03 24.90 471 158921 56282 90412773
Glossodynia 356.34 24.90 1309 158083 320470 90148585
Dislocation of vertebra 352.74 24.90 463 158929 55505 90413550
Wound 347.71 24.90 1247 158145 301733 90167322
Pemphigus 340.59 24.90 1304 158088 325560 90143495
Lip dry 338.47 24.90 624 158768 100331 90368724
Blister 337.65 24.90 1101 158291 253897 90215158
Lower respiratory tract infection 337.07 24.90 1088 158304 249571 90219484
Fibromyalgia 336.17 24.90 958 158434 205311 90263744
Facet joint syndrome 336.00 24.90 613 158779 97776 90371279
Lupus vulgaris 333.63 24.90 404 158988 44655 90424400
Anti-cyclic citrullinated peptide antibody positive 333.20 24.90 1043 158349 235390 90233665
Psoriatic arthropathy 325.19 24.90 1011 158381 227324 90241731
Rheumatoid factor positive 319.34 24.90 837 158555 170813 90298242
Grip strength decreased 316.39 24.90 577 158815 91999 90377056
Back pain 315.50 24.90 84 159308 317091 90151964
Exposure to toxic agent 311.66 24.90 187 159205 7780 90461275
Neutropenia 310.42 24.90 22 159370 224882 90244173
Road traffic accident 309.05 24.90 623 158769 107003 90362052
Wound infection 308.02 24.90 618 158774 105784 90363271
Acute kidney injury 307.26 24.90 91 159301 320296 90148759
Amnesia 306.71 24.90 624 158768 107881 90361174
Suicide attempt 291.34 24.90 496 158896 74903 90394152
Deep vein thrombosis postoperative 289.85 24.90 478 158914 70331 90398724
Erythema 285.53 24.90 34 159358 229212 90239843
Stomatitis 279.54 24.90 1088 158304 273610 90195445
Victim of crime 278.05 24.90 90 159302 782 90468273
Alcohol poisoning 273.57 24.90 109 159283 1803 90467252
C-reactive protein abnormal 271.10 24.90 654 158738 126775 90342280
Blood cholesterol increased 268.83 24.90 891 158501 207121 90261934
Breast cancer stage III 264.41 24.90 507 158885 83940 90385115
Fall 257.22 24.90 281 159111 481529 89987526
X-ray abnormal 250.14 24.90 352 159040 45072 90423983
Synovitis 249.35 24.90 1194 158198 328558 90140497
Hepatic enzyme increased 247.83 24.90 1271 158121 359465 90109590
Pulmonary fibrosis 244.12 24.90 566 158826 106937 90362118
Discomfort 242.21 24.90 1040 158352 273295 90195760
Systemic lupus erythematosus 241.62 24.90 1265 158127 360631 90108424
Gait inability 234.38 24.90 676 158716 145780 90323275
Lower limb fracture 233.24 24.90 483 158909 84530 90384525
Injection site pain 231.22 24.90 20 159372 173679 90295376
Sepsis 230.63 24.90 24 159368 179790 90289265
Confusional state 230.26 24.90 1309 158083 384896 90084159
Diarrhoea 224.66 24.90 872 158520 938318 89530737
Autoimmune disorder 223.55 24.90 447 158945 76297 90392758
COVID-19 223.24 24.90 20 159372 168823 90300232
Blood pressure increased 222.92 24.90 39 159353 197178 90271877
White blood cell count decreased 220.39 24.90 20 159372 167089 90301966
Febrile neutropenia 219.89 24.90 15 159377 158334 90310721
Mobility decreased 216.29 24.90 944 158448 249790 90219265
Overdose 214.00 24.90 687 158705 157022 90312033
Contusion 213.03 24.90 941 158451 250275 90218780
Nausea 211.21 24.90 1122 158270 1109194 89359861
Dehydration 208.04 24.90 44 159348 194403 90274652
Liver disorder 207.96 24.90 574 158818 120695 90348360
Haemoglobin decreased 206.72 24.90 22 159370 161934 90307121
Off label use 204.03 24.90 1124 158268 1101128 89367927
Delirium 200.23 24.90 515 158877 103844 90365211
Retinitis 199.95 24.90 290 159102 38168 90430887
Wheezing 199.74 24.90 889 158503 237191 90231864
Gastrointestinal disorder 198.68 24.90 936 158456 255751 90213304
Peripheral venous disease 198.42 24.90 449 158943 83472 90385583
Anti-cyclic citrullinated peptide antibody 196.50 24.90 241 159151 26980 90442075
Disease progression 195.54 24.90 23 159369 156592 90312463
Walking aid user 193.79 24.90 274 159118 35232 90433823
Porphyria acute 189.67 24.90 194 159198 17781 90451274
Neuropathy peripheral 187.22 24.90 14 159378 136956 90332099
Oedema 178.72 24.90 762 158630 199533 90269522
Influenza 177.52 24.90 19 159373 139245 90329810
Prescribed overdose 174.26 24.90 469 158923 97156 90371899
Bone erosion 174.19 24.90 325 159067 52696 90416359
Substance use disorder 172.72 24.90 80 159312 1940 90467115
Cerebrovascular accident 167.78 24.90 13 159379 123520 90345535
Infusion related reaction 167.50 24.90 1280 158112 415500 90053555
Sciatica 167.04 24.90 473 158919 100909 90368146
Feeling abnormal 166.73 24.90 44 159348 167191 90301864
Exostosis 166.27 24.90 319 159073 52815 90416240
Hyponatraemia 165.74 24.90 20 159372 133518 90335537
Lupus-like syndrome 164.98 24.90 303 159089 48543 90420512
Obesity 163.94 24.90 482 158910 105025 90364030
Bursitis 163.81 24.90 557 158835 131097 90337958
Chest discomfort 161.61 24.90 25 159367 138340 90330715
Pulmonary embolism 161.36 24.90 20 159372 130800 90338255
Dyspepsia 160.20 24.90 732 158660 197428 90271627
Ulcer haemorrhage 160.02 24.90 214 159178 26107 90442948
Platelet count decreased 159.40 24.90 25 159367 136944 90332111
Rheumatoid arthritis 156.64 24.90 1133 158259 361481 90107574
General physical health deterioration 155.95 24.90 1114 158278 354001 90115054
Pancytopenia 154.32 24.90 16 159376 120247 90348808
Chills 153.80 24.90 24 159368 131957 90337098
Subcutaneous drug absorption impaired 153.57 24.90 152 159240 13393 90455662
Fatigue 152.63 24.90 1299 158093 1152724 89316331
Oropharyngeal pain 151.29 24.90 14 159378 115173 90353882
Laryngitis 150.64 24.90 298 159094 50455 90418600
Night sweats 149.97 24.90 533 158859 128233 90340822
Malignant neoplasm progression 148.72 24.90 10 159382 106860 90362195
Onychomycosis 148.47 24.90 249 159143 37127 90431928
Myalgia 148.42 24.90 61 159331 175064 90293991
Respiratory arrest 147.35 24.90 233 159159 33078 90435977
Hepatic cirrhosis 146.81 24.90 336 159056 62917 90406138
Renal impairment 143.43 24.90 11 159381 105410 90363645
Infection 142.59 24.90 1107 158285 360987 90108068
Renal failure 141.43 24.90 29 159363 130978 90338077
Vision blurred 140.68 24.90 15 159377 110278 90358777
Herpes zoster 140.60 24.90 6 159386 94638 90374417
Palpitations 140.09 24.90 34 159358 136694 90332361
Syncope 137.87 24.90 32 159360 132631 90336424
Arthropathy 135.63 24.90 1104 158288 365138 90103917
Injection site erythema 134.80 24.90 10 159382 98492 90370563
Onychomadesis 132.82 24.90 267 159125 45731 90423324
Prescribed underdose 132.45 24.90 359 159033 74660 90394395
Dysphagia 131.77 24.90 20 159372 112258 90356797
Memory impairment 131.75 24.90 690 158702 196554 90272501
Alcohol use 131.42 24.90 63 159329 1654 90467401
General symptom 131.18 24.90 145 159247 14523 90454532
Urticaria 128.63 24.90 966 158426 311768 90157287
Drug use disorder 128.31 24.90 111 159281 8232 90460823
Myocardial infarction 126.39 24.90 18 159374 105954 90363101
Swelling 126.11 24.90 1207 158185 417851 90051204
Cardiac failure congestive 124.41 24.90 14 159378 98680 90370375
Alcohol abuse 124.21 24.90 64 159328 1969 90467086
Disability 123.05 24.90 241 159151 40504 90428551
Atrial fibrillation 122.52 24.90 41 159351 133570 90335485
Hypotension 122.34 24.90 242 159150 325155 90143900
Nasal congestion 121.59 24.90 6 159386 83408 90385647
Rhinorrhoea 120.76 24.90 9 159383 88307 90380748
Inappropriate schedule of product administration 119.52 24.90 57 159335 149876 90319179
Pustular psoriasis 119.18 24.90 155 159237 18401 90450654
Chemical submission 118.87 24.90 42 159350 488 90468567
Cellulitis 117.58 24.90 12 159380 91325 90377730
Dry skin 117.56 24.90 10 159382 88063 90380992
Septic shock 116.73 24.90 8 159384 84152 90384903
Intentional product use issue 116.66 24.90 716 158676 216176 90252879
Lung disorder 115.44 24.90 546 158846 149337 90319718
Hip arthroplasty 115.36 24.90 345 159047 75863 90393192
Rash vesicular 115.31 24.90 151 159241 18046 90451009
Inflammation 114.64 24.90 618 158774 177974 90291081
Respiratory failure 114.57 24.90 33 159359 118385 90350670
Hypoaesthesia 114.04 24.90 943 158449 313267 90155788
Hypersensitivity 113.23 24.90 1260 158132 453417 90015638
Epistaxis 112.71 24.90 10 159382 85115 90383940
Dry mouth 111.51 24.90 627 158765 183432 90285623
Gastrointestinal haemorrhage 110.80 24.90 14 159378 90234 90378821
Haematochezia 110.58 24.90 3 159389 70910 90398145
Headache 108.08 24.90 984 158408 861762 89607293
Thrombosis 107.63 24.90 5 159387 73246 90395809
Hyperhidrosis 106.85 24.90 53 159339 136252 90332803
Interstitial lung disease 106.74 24.90 7 159385 76398 90392657
Intentional product misuse 105.24 24.90 372 159020 89232 90379823
Medication error 105.12 24.90 358 159034 84294 90384761
Osteoarthritis 104.53 24.90 645 158747 195085 90273970
Nasopharyngitis 104.46 24.90 1135 158257 405969 90063086
Blood creatinine increased 104.27 24.90 25 159367 101361 90367694
Anaphylactic reaction 104.07 24.90 15 159377 87509 90381546
Joint dislocation 103.64 24.90 237 159155 44345 90424710
Maternal exposure timing unspecified 103.24 24.90 160 159232 22323 90446732
Grip strength 102.37 24.90 101 159291 8864 90460191
Balance disorder 101.70 24.90 23 159369 97057 90371998
Insomnia 100.49 24.90 961 158431 332513 90136542
Illness 99.94 24.90 13 159379 81956 90387099
Sinusitis 99.61 24.90 981 158411 342107 90126948
Heart rate increased 99.48 24.90 37 159355 112865 90356190
Deep vein thrombosis 99.47 24.90 20 159372 91600 90377455
Pleural effusion 98.18 24.90 37 159355 111954 90357101
C-reactive protein 97.73 24.90 188 159204 31179 90437876
Weight increased 97.19 24.90 1143 158249 416784 90052271
Productive cough 96.96 24.90 11 159381 77052 90392003
Cataract 96.73 24.90 8 159384 72084 90396971
Tremor 96.08 24.90 77 159315 153096 90315959
Influenza like illness 95.41 24.90 14 159378 80597 90388458
Breast cancer stage II 94.81 24.90 199 159193 35135 90433920
Dyspnoea exertional 94.35 24.90 9 159383 72279 90396776
Back disorder 94.22 24.90 165 159227 25466 90443589
Eye injury 93.51 24.90 106 159286 10914 90458141
Colitis 93.19 24.90 8 159384 69934 90399121
Neutrophil count decreased 93.11 24.90 9 159383 71523 90397532
Thrombocytopenia 92.30 24.90 140 159252 208585 90260470
Hypokalaemia 91.27 24.90 59 159333 131057 90337998
Incorrect dose administered 90.49 24.90 15 159377 78915 90390140
Angioedema 90.47 24.90 6 159386 64870 90404185
Skin exfoliation 89.85 24.90 8 159384 67905 90401150
Chronic obstructive pulmonary disease 89.31 24.90 12 159380 73817 90395238
Foot deformity 89.29 24.90 269 159123 59382 90409673
Blood pressure systolic increased 89.05 24.90 3 159389 58342 90410713
Migraine 88.56 24.90 606 158786 189786 90279269
Blood glucose increased 87.71 24.90 29 159363 95217 90373838
Asthenia 87.32 24.90 565 158827 533186 89935869
Flushing 86.82 24.90 24 159368 88467 90380588
Cardiac failure 85.18 24.90 43 159349 109453 90359602
Musculoskeletal stiffness 85.12 24.90 846 158546 295686 90173369
Dysphonia 84.64 24.90 7 159385 63077 90405978
Myositis 84.41 24.90 152 159240 23976 90445079
Alanine aminotransferase increased 84.08 24.90 52 159340 118286 90350769
Stress 83.84 24.90 20 159372 81375 90387680
Rash erythematous 82.65 24.90 9 159383 65095 90403960
Swelling face 81.83 24.90 21 159371 81331 90387724
Musculoskeletal pain 80.78 24.90 547 158845 170704 90298351
Drug interaction 80.55 24.90 235 159157 276218 90192837
Bone pain 80.15 24.90 8 159384 61975 90407080
Joint swelling 80.01 24.90 1286 158106 502014 89967041
Poisoning deliberate 79.47 24.90 120 159272 16366 90452689
Injection site swelling 79.30 24.90 7 159385 59832 90409223
Substance abuse 79.27 24.90 70 159322 5336 90463719
Knee arthroplasty 78.43 24.90 322 159070 82860 90386195
Mucosal inflammation 78.42 24.90 6 159386 57619 90411436
Pneumonia 78.35 24.90 731 158661 637328 89831727
Injection site pruritus 78.05 24.90 4 159388 53830 90415225
Hyperkalaemia 77.54 24.90 11 159381 64953 90404102
Burning sensation 77.51 24.90 10 159382 63442 90405613
Diabetes mellitus 77.40 24.90 11 159381 64864 90404191
Blood pressure fluctuation 75.66 24.90 4 159388 52409 90416646
Therapy interrupted 75.01 24.90 3 159389 50105 90418950
Bradycardia 74.67 24.90 27 159365 83820 90385235
Adverse event 74.42 24.90 405 158987 117013 90352042
Multiple sclerosis relapse 72.45 24.90 5 159387 52300 90416755
Nail disorder 71.75 24.90 248 159144 58819 90410236
Dysgeusia 70.05 24.90 6 159386 52554 90416501
Cardiac disorder 69.38 24.90 9 159383 56863 90412192
Ear infection 68.88 24.90 274 159118 69501 90399554
Vertigo 68.36 24.90 19 159373 69792 90399263
Pain in jaw 68.22 24.90 4 159388 47981 90421074
Lymphadenopathy 67.66 24.90 3 159389 45772 90423283
Victim of sexual abuse 67.24 24.90 30 159362 665 90468390
Aspartate aminotransferase increased 66.76 24.90 50 159342 102887 90366168
Live birth 66.67 24.90 296 159096 78811 90390244
Dry eye 66.43 24.90 11 159381 57920 90411135
Chronic kidney disease 66.16 24.90 6 159386 50185 90418870
Drug-induced liver injury 65.88 24.90 324 159068 89994 90379061
Drug ineffective for unapproved indication 65.52 24.90 18 159374 66626 90402429
Peripheral swelling 65.40 24.90 1055 158337 412051 90057004
Eczema 65.38 24.90 8 159384 52862 90416193
Wrong technique in product usage process 63.81 24.90 23 159369 71548 90397507
Throat irritation 63.71 24.90 6 159386 48689 90420366
Pain 63.32 24.90 1305 158087 995036 89474019
Blood alcohol increased 62.97 24.90 27 159365 542 90468513
Red blood cell count decreased 62.58 24.90 5 159387 46346 90422709
Drug reaction with eosinophilia and systemic symptoms 62.55 24.90 3 159389 42755 90426300
Cholelithiasis 62.41 24.90 9 159383 52497 90416558
Swollen tongue 61.93 24.90 5 159387 45951 90423104
Hypocalcaemia 61.89 24.90 3 159389 42365 90426690
Pneumonitis 61.84 24.90 4 159388 44166 90424889
Hypothyroidism 61.11 24.90 10 159382 53117 90415938
Skin ulcer 60.90 24.90 8 159384 50067 90418988
Diverticulitis 60.66 24.90 5 159387 45182 90423873
Hot flush 60.51 24.90 15 159377 59473 90409582
Fungal infection 59.32 24.90 4 159388 42657 90426398
Cognitive disorder 59.06 24.90 24 159368 69383 90399672
Poisoning 58.60 24.90 100 159292 15117 90453938
Mydriasis 58.26 24.90 99 159293 14913 90454142
Mouth ulceration 57.86 24.90 3 159389 39971 90429084
Unevaluable event 57.43 24.90 13 159379 54835 90414220
Ascites 57.17 24.90 8 159384 47732 90421323
Dysuria 56.89 24.90 3 159389 39398 90429657
Swollen joint count 56.69 24.90 73 159319 8580 90460475
Postmortem blood drug level abnormal 56.63 24.90 20 159372 232 90468823
Rash maculo-papular 56.44 24.90 4 159388 40929 90428126
Hyperglycaemia 55.59 24.90 11 159381 50959 90418096
C-reactive protein increased 54.69 24.90 523 158869 180866 90288189
Blood pressure decreased 54.47 24.90 32 159360 74863 90394192
Abdominal pain 54.42 24.90 440 158952 395281 90073774
Flatulence 54.38 24.90 5 159387 41362 90427693
Skin discolouration 54.08 24.90 7 159385 44308 90424747
Breast cancer 53.83 24.90 14 159378 53747 90415308
Oxygen saturation decreased 53.63 24.90 66 159326 107417 90361638
Heart rate decreased 53.45 24.90 14 159378 53491 90415564
Coma 53.29 24.90 261 159131 72371 90396684
Methaemoglobinaemia 52.99 24.90 49 159343 3966 90465089
Orthostatic hypotension 52.54 24.90 6 159386 41821 90427234
Transient ischaemic attack 52.26 24.90 7 159385 43169 90425886
Limb discomfort 51.68 24.90 4 159388 38056 90430999
Contraindicated product administered 51.53 24.90 820 158572 319319 90149736
Adverse reaction 50.25 24.90 140 159252 29572 90439483
Alcoholism 49.88 24.90 34 159358 1766 90467289
Acute myocardial infarction 49.32 24.90 3 159389 34887 90434168
Leukopenia 49.04 24.90 63 159329 100647 90368408
Pulmonary hypertension 48.92 24.90 8 159384 42515 90426540
Abortion spontaneous 48.83 24.90 17 159375 54039 90415016
Therapeutic product effect decreased 48.51 24.90 721 158671 276850 90192205
Angina pectoris 48.24 24.90 6 159386 39154 90429901
Hypercalcaemia 48.23 24.90 3 159389 34237 90434818
International normalised ratio increased 47.99 24.90 12 159380 47304 90421751
Abdominal discomfort 47.38 24.90 1136 158256 476192 89992863
Blepharospasm 47.12 24.90 208 159184 55237 90413818
Red blood cell sedimentation rate increased 47.11 24.90 277 159115 82318 90386737
Finger deformity 47.02 24.90 146 159246 32751 90436304
Nephrolithiasis 46.88 24.90 14 159378 49071 90419984
Hypertension 46.66 24.90 1093 158299 456439 90012616
Agranulocytosis 46.64 24.90 4 159388 34998 90434057
Cardiac arrest 46.40 24.90 330 159062 104605 90364450
Drug tolerance decreased 46.30 24.90 143 159249 31987 90437068
Haematocrit decreased 45.68 24.90 9 159383 41823 90427232
Tinnitus 45.56 24.90 10 159382 43092 90425963
Hypophagia 45.53 24.90 5 159387 35932 90433123
Viral infection 45.03 24.90 9 159383 41405 90427650
Neoplasm malignant 44.79 24.90 4 159388 33876 90435179
Joint stiffness 44.69 24.90 262 159130 77780 90391275
Alopecia 44.32 24.90 1162 158230 493909 89975146
Skin disorder 44.31 24.90 6 159386 36700 90432355
Presyncope 44.17 24.90 3 159389 31802 90437253
Pregnancy 44.12 24.90 221 159171 61826 90407229
Gastric disorder 43.98 24.90 4 159388 33380 90435675
Haemoptysis 43.87 24.90 4 159388 33316 90435739
Limb injury 43.67 24.90 3 159389 31505 90437550
Blood alkaline phosphatase increased 43.63 24.90 15 159377 48064 90420991
Device dislocation 43.63 24.90 3 159389 31479 90437576
Back injury 43.56 24.90 180 159212 46442 90422613
Seronegative arthritis 43.56 24.90 98 159294 18136 90450919
Disease recurrence 43.50 24.90 7 159385 37646 90431409
Hip fracture 43.48 24.90 4 159388 33073 90435982
Haemorrhage 43.32 24.90 35 159357 69334 90399721
Premature delivery 43.04 24.90 8 159384 38754 90430301
Liver function test increased 42.99 24.90 276 159116 84579 90384476
Lip swelling 42.81 24.90 8 159384 38602 90430453
Dyspnoea 42.61 24.90 1202 158190 879753 89589302
Hypomagnesaemia 42.53 24.90 6 159386 35582 90433473
Candida infection 42.49 24.90 5 159387 34052 90435003
Drug resistance 41.91 24.90 3 159389 30446 90438609
Rash macular 41.63 24.90 3 159389 30277 90438778
Oral herpes 41.63 24.90 5 159387 33519 90435536
Gastritis 41.56 24.90 11 159381 41742 90427313
Cholestasis 41.38 24.90 7 159385 36292 90432763
Melaena 41.27 24.90 6 159386 34791 90434264
Cerebral haemorrhage 40.84 24.90 6 159386 34516 90434539
Staphylococcal infection 40.81 24.90 17 159375 48422 90420633
Respiratory tract infection 40.54 24.90 27 159365 59051 90410004
Hypervolaemia 40.40 24.90 5 159387 32752 90436303
Tooth disorder 40.23 24.90 4 159388 31086 90437969
Eye swelling 40.15 24.90 3 159389 29383 90439672
Eye irritation 39.98 24.90 6 159386 33972 90435083
Blood potassium decreased 39.81 24.90 17 159375 47710 90421345
Renal disorder 39.58 24.90 9 159383 37850 90431205
Aphasia 39.47 24.90 13 159379 42799 90426256
Coronary artery disease 39.42 24.90 6 159386 33617 90435438
Localised infection 39.32 24.90 6 159386 33556 90435499
Product label confusion 38.97 24.90 108 159284 22742 90446313
Skin lesion 38.83 24.90 9 159383 37356 90431699
Acne 38.70 24.90 3 159389 28504 90440551
Neuralgia 38.38 24.90 5 159387 31495 90437560
Injection site haemorrhage 38.38 24.90 3 159389 28315 90440740
Eye pain 38.02 24.90 15 159377 44153 90424902
Emotional distress 37.77 24.90 9 159383 36653 90432402
Haematemesis 37.37 24.90 7 159385 33719 90435336
Sleep disorder due to a general medical condition 36.64 24.90 166 159226 44572 90424483
Frequent bowel movements 36.47 24.90 197 159195 56738 90412317
Lacrimation increased 36.31 24.90 3 159389 27059 90441996
Anaphylactic shock 36.26 24.90 6 159386 31611 90437444
Product prescribing error 36.22 24.90 5 159387 30140 90438915
Tenderness 35.99 24.90 3 159389 26865 90442190
Haematoma 35.75 24.90 12 159380 39036 90430019
Vaginal haemorrhage 35.71 24.90 6 159386 31265 90437790
Liver function test abnormal 35.21 24.90 23 159369 50822 90418233
Immunodeficiency 35.11 24.90 16 159376 43218 90425837
Colitis ulcerative 34.94 24.90 203 159189 60063 90408992
Feeling cold 34.35 24.90 4 159388 27461 90441594
Device related infection 34.21 24.90 3 159389 25783 90443272
Paraesthesia oral 34.17 24.90 7 159385 31652 90437403
Multiple organ dysfunction syndrome 34.05 24.90 42 159350 68294 90400761
Diplopia 33.94 24.90 5 159387 28709 90440346
Blood bilirubin increased 33.91 24.90 17 159375 43453 90425602
Bronchitis 33.81 24.90 146 159246 152781 90316274
Metastases to bone 33.75 24.90 3 159389 25502 90443553
Food allergy 33.70 24.90 3 159389 25475 90443580
Victim of chemical submission 33.26 24.90 19 159373 720 90468335
Conjunctivitis 33.12 24.90 4 159388 26702 90442353
Blindness 32.90 24.90 4 159388 26564 90442491
Pancreatitis acute 32.85 24.90 8 159384 32107 90436948
Speech disorder 32.42 24.90 20 159372 45565 90423490
Hemiparesis 32.41 24.90 8 159384 31811 90437244
Gastroenteritis viral 32.17 24.90 7 159385 30348 90438707
Diabetic ketoacidosis 31.95 24.90 3 159389 24404 90444651
Urinary incontinence 31.94 24.90 13 159379 37553 90431502
Metastases to liver 31.87 24.90 6 159386 28801 90440254
Kidney infection 31.85 24.90 4 159388 25912 90443143
Obstructive airways disorder 31.78 24.90 4 159388 25865 90443190
Joint injury 31.77 24.90 9 159383 32655 90436400
Intervertebral disc protrusion 31.55 24.90 5 159387 27191 90441864
Haematuria 31.53 24.90 11 159381 34926 90434129
Blood pressure diastolic decreased 30.96 24.90 5 159387 26821 90442234
Nodule 30.74 24.90 5 159387 26681 90442374
Surgery 30.15 24.90 21 159371 44866 90424189
Incorrect route of product administration 29.65 24.90 171 159221 50455 90418600
Upper gastrointestinal haemorrhage 29.61 24.90 3 159389 22973 90446082
Head injury 29.59 24.90 9 159383 31179 90437876
Gamma-glutamyltransferase increased 29.36 24.90 15 159377 37937 90431118
Hepatic function abnormal 29.35 24.90 23 159369 46265 90422790
Disturbance in attention 29.13 24.90 24 159368 47085 90421970
Depression 29.04 24.90 713 158679 299888 90169167
Throat tightness 28.91 24.90 8 159384 29476 90439579
Epilepsy 28.83 24.90 245 159147 81961 90387094
Hypoxia 28.78 24.90 52 159340 72347 90396708
Hiatus hernia 28.67 24.90 5 159387 25356 90443699
Posterior reversible encephalopathy syndrome 28.58 24.90 3 159389 22336 90446719
Bronchiectasis 28.56 24.90 3 159389 22327 90446728
Osteoporosis 28.42 24.90 277 159115 96254 90372801
Multiple sclerosis 28.35 24.90 7 159385 27833 90441222
Iron deficiency anaemia 28.25 24.90 4 159388 23658 90445397
Premature baby 28.22 24.90 5 159387 25072 90443983
Rib fracture 28.21 24.90 6 159386 26429 90442626
Fracture 28.15 24.90 3 159389 22073 90446982
Dermatitis atopic 27.95 24.90 4 159388 23468 90445587
Osteonecrosis 27.92 24.90 6 159386 26235 90442820
Bacterial infection 27.91 24.90 4 159388 23440 90445615
Hepatic cytolysis 27.45 24.90 10 159382 30906 90438149
Therapy non-responder 27.44 24.90 364 159028 136340 90332715
Dizziness 27.42 24.90 808 158584 588476 89880579
Upper limb fracture 27.34 24.90 3 159389 21575 90447480
Osteopenia 27.20 24.90 4 159388 22998 90446057
Sleep apnoea syndrome 26.97 24.90 11 159381 31736 90437319
Faeces discoloured 26.92 24.90 3 159389 21317 90447738
Blood urea increased 26.73 24.90 10 159382 30403 90438652
Ocular hyperaemia 26.69 24.90 13 159379 33785 90435270
Arthralgia 26.68 24.90 1109 158283 777413 89691642
Foot fracture 26.50 24.90 7 159385 26599 90442456
Cerebral infarction 26.48 24.90 7 159385 26589 90442466
Musculoskeletal discomfort 26.39 24.90 3 159389 20988 90448067
Bacteraemia 26.09 24.90 4 159388 22296 90446759
Blood potassium increased 26 24.90 3 159389 20746 90448309
Protein C increased 25.75 24.90 8 159384 60 90468995
Heavy menstrual bleeding 25.65 24.90 3 159389 20527 90448528
Pollakiuria 25.60 24.90 13 159379 32992 90436063
Blood lactate dehydrogenase increased 25.49 24.90 7 159385 25925 90443130
Hypoglycaemia 25.31 24.90 53 159339 69795 90399260
Acute respiratory failure 25.16 24.90 23 159369 42895 90426160
Blood ethanol increased 25.06 24.90 9 159383 110 90468945
Seasonal allergy 24.98 24.90 5 159387 22978 90446077

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 7610.25 18.39 2895 30656 101876 42485908
Completed suicide 5271.90 18.39 2177 31374 94288 42493496
Toxicity to various agents 4621.44 18.39 2605 30946 226531 42361253
Cardio-respiratory arrest 1041.65 18.39 620 32931 58016 42529768
Intentional overdose 876.96 18.39 530 33021 50926 42536858
Substance use disorder 735.54 18.39 240 33311 5105 42582679
Overdose 692.75 18.39 609 32942 104655 42483129
Drug use disorder 649.89 18.39 260 33291 10073 42577711
Alcohol abuse 610.93 18.39 195 33356 3854 42583930
Alcohol interaction 593.90 18.39 165 33386 1970 42585814
Intentional product misuse 574.84 18.39 438 33113 61462 42526322
Suicide attempt 564.75 18.39 386 33165 45714 42542070
Suspected suicide 551.81 18.39 201 33350 5998 42581786
Coma 512.70 18.39 386 33165 53168 42534616
Drug dependence 444.88 18.39 280 33271 28814 42558970
Substance abuse 398.71 18.39 176 33375 8729 42579055
Exposure to toxic agent 392.94 18.39 148 33403 4856 42582928
Poisoning 353.77 18.39 190 33361 14509 42573275
Alcohol poisoning 333.61 18.39 148 33403 7426 42580358
Asphyxia 323.31 18.39 149 33402 8177 42579607
Aggression 288.62 18.39 255 33296 43908 42543876
Respiratory arrest 283.13 18.39 210 33341 28214 42559570
Poisoning deliberate 249.44 18.39 133 33418 10001 42577783
Respiratory depression 240.26 18.39 162 33389 18706 42569078
Miosis 240.14 18.39 143 33408 13303 42574481
Off label use 202.94 18.39 127 33424 638208 41949576
Drug ineffective 192.66 18.39 131 33420 630066 41957718
Alcohol use 190.58 18.39 75 33476 2773 42585011
Agitation 164.70 18.39 227 33324 64087 42523697
Prescription drug used without a prescription 158.82 18.39 65 33486 2665 42585119
Diarrhoea 158.53 18.39 83 33468 460766 42127018
Cardiac arrest 157.63 18.39 297 33254 109023 42478761
Suicidal ideation 146.48 18.39 185 33366 47976 42539808
Fatigue 137.58 18.39 87 33464 435554 42152230
Death 136.44 18.39 729 32822 470456 42117328
Tachycardia 131.48 18.39 263 33288 100824 42486960
Pneumonia 123.02 18.39 92 33459 422057 42165727
Blood alcohol increased 120.50 18.39 36 33515 564 42587220
Pyrexia 119.87 18.39 82 33469 393960 42193824
Mydriasis 118.10 18.39 78 33473 8692 42579092
Depressed level of consciousness 114.85 18.39 164 33387 47806 42539978
Anaemia 109.44 18.39 42 33509 280236 42307548
Neutropenia 102.49 18.39 17 33534 199414 42388370
Accidental death 100.71 18.39 49 33502 3034 42584750
Drug withdrawal syndrome 96.26 18.39 101 33450 21448 42566336
Incorrect route of product administration 94.72 18.39 106 33445 24199 42563585
Dyspnoea 91.97 18.39 129 33422 442492 42145292
Cough 89.70 18.39 16 33535 178087 42409697
Intentional self-injury 87.86 18.39 82 33469 15120 42572664
Febrile neutropenia 86.64 18.39 20 33531 185683 42402101
Rash 84.94 18.39 57 33494 276897 42310887
Alcohol withdrawal syndrome 82.53 18.39 34 33517 1417 42586367
Bradypnoea 81.75 18.39 48 33503 4345 42583439
Intentional product use issue 80.60 18.39 176 33375 71657 42516127
Drug screen positive 79.15 18.39 46 33505 4085 42583699
Altered state of consciousness 77.42 18.39 105 33446 29154 42558630
Withdrawal syndrome 72.77 18.39 73 33478 14702 42573082
Methaemoglobinaemia 72.08 18.39 49 33502 5725 42582059
Impaired driving ability 70.49 18.39 38 33513 2917 42584867
Arthralgia 70.26 18.39 37 33514 205201 42382583
Somnolence 69.98 18.39 257 33294 140848 42446936
Condition aggravated 66.98 18.39 64 33487 260690 42327094
Loss of consciousness 66.40 18.39 191 33360 92163 42495621
Pain 65.36 18.39 58 33493 244790 42342994
Disease progression 64.01 18.39 17 33534 143639 42444145
Abnormal behaviour 61.18 18.39 89 33462 26362 42561422
Road traffic accident 60.64 18.39 75 33476 19018 42568766
Alcohol intolerance 60.58 18.39 19 33532 353 42587431
Alcoholism 59.80 18.39 34 33517 2896 42584888
Sepsis 59.75 18.39 42 33509 199292 42388492
Product dose omission issue 58.73 18.39 24 33527 154341 42433443
Amnesia 57.68 18.39 90 33461 28347 42559437
Pruritus 56.28 18.39 40 33511 188731 42399053
Drug interaction 56.25 18.39 381 33170 266618 42321166
Decreased appetite 56.19 18.39 42 33509 193095 42394689
Constipation 55.90 18.39 29 33522 162262 42425522
Nausea 54.22 18.39 148 33403 396651 42191133
Pain in extremity 53.23 18.39 26 33525 150578 42437206
COVID-19 53.03 18.39 13 33538 115935 42471849
Pulmonary oedema 52.47 18.39 124 33427 53148 42534636
Malignant neoplasm progression 51.88 18.39 11 33540 108389 42479395
Medication error 51.34 18.39 93 33458 33061 42554723
Ex-drug abuser 50.77 18.39 12 33539 70 42587714
Pancytopenia 50.46 18.39 15 33536 117728 42470056
Cerebrovascular accident 48.29 18.39 9 33542 97151 42490633
General physical health deterioration 47.83 18.39 30 33521 151216 42436568
Platelet count decreased 47.36 18.39 25 33526 138556 42449228
Behavioural addiction 44.94 18.39 11 33540 76 42587708
Hypothermia 44.39 18.39 52 33499 12463 42575321
Asthenia 44.38 18.39 97 33454 280696 42307088
Thrombocytopenia 43.99 18.39 51 33500 190228 42397556
Urinary tract infection 43.74 18.39 12 33539 99272 42488512
Nasopharyngitis 43.45 18.39 7 33544 83989 42503795
Brain oedema 42.28 18.39 58 33493 16269 42571515
Sopor 42.15 18.39 52 33499 13150 42574634
Neuropathy peripheral 41.81 18.39 14 33537 101839 42485945
Drug abuser 41.80 18.39 29 33522 3502 42584282
Back pain 40.99 18.39 31 33520 141745 42446039
Weight decreased 40.69 18.39 63 33488 207885 42379899
White blood cell count decreased 40.63 18.39 18 33533 110378 42477406
Peripheral swelling 39.59 18.39 11 33540 90259 42497525
Blood ethanol 39.35 18.39 10 33541 82 42587702
Opiates positive 38.69 18.39 15 33536 532 42587252
Haemoglobin decreased 38.25 18.39 29 33522 132442 42455342
Hepatic fibrosis 37.63 18.39 31 33520 4841 42582943
Renal impairment 37.49 18.39 20 33531 110208 42477576
Septic shock 36.93 18.39 13 33538 91659 42496125
Behaviour disorder 36.86 18.39 36 33515 7018 42580766
Malaise 36.28 18.39 70 33481 212086 42375698
Infection 35.73 18.39 22 33529 112046 42475738
Interstitial lung disease 35.47 18.39 9 33542 78453 42509331
Oedema peripheral 35.35 18.39 33 33518 136043 42451741
Inappropriate schedule of product administration 34.72 18.39 16 33535 95886 42491898
Foetal alcohol syndrome 34.48 18.39 9 33542 83 42587701
Joint swelling 34.45 18.39 6 33545 68016 42519768
Homicide 34.34 18.39 16 33535 899 42586885
Unresponsive to stimuli 34.12 18.39 76 33475 31327 42556457
Adulterated product 33.82 18.39 15 33536 751 42587033
Blood ethanol increased 33.64 18.39 13 33538 457 42587327
Pulmonary embolism 33.50 18.39 27 33524 119585 42468199
Delirium tremens 33.22 18.39 14 33537 618 42587166
Metabolic acidosis 33.21 18.39 103 33448 51755 42536029
Postmortem blood drug level increased 32.34 18.39 13 33538 508 42587276
Myocardial fibrosis 32.11 18.39 17 33534 1258 42586526
Physical assault 31.78 18.39 16 33535 1066 42586718
Atrial fibrillation 31.61 18.39 38 33513 139555 42448229
Cardiac failure congestive 31.43 18.39 14 33537 85588 42502196
Drug intolerance 31.39 18.39 12 33539 80412 42507372
Pleural effusion 31.08 18.39 19 33532 97147 42490637
Treatment failure 30.69 18.39 6 33545 62618 42525166
Urticaria 30.69 18.39 10 33541 74026 42513758
Rhabdomyolysis 29.73 18.39 131 33420 77888 42509896
Product use in unapproved indication 29.70 18.39 63 33488 184393 42403391
Dysarthria 29.23 18.39 83 33468 39724 42548060
Neutrophil count decreased 29.20 18.39 7 33544 63408 42524376
Acute kidney injury 29.07 18.39 170 33381 367167 42220617
Postmortem blood drug level 28.96 18.39 9 33542 162 42587622
Stomatitis 28.90 18.39 3 33548 50326 42537458
Dehydration 28.63 18.39 42 33509 141725 42446059
Loss of personal independence in daily activities 28.52 18.39 3 33548 49813 42537971
Dizziness 28.28 18.39 101 33450 249153 42338631
Weight increased 28.26 18.39 26 33525 107957 42479827
Headache 27.15 18.39 97 33454 239272 42348512
Dextrocardia 26.97 18.39 7 33544 63 42587721
Somnambulism 26.94 18.39 22 33529 3393 42584391
Plasma cell myeloma 26.90 18.39 3 33548 47575 42540209
Sensorimotor disorder 26.87 18.39 11 33540 451 42587333
Potentiating drug interaction 26.55 18.39 29 33522 6439 42581345
Accidental poisoning 26.34 18.39 15 33536 1281 42586503
Dyspnoea exertional 26.34 18.39 4 33547 50144 42537640
Cellulitis 26.09 18.39 8 33543 61577 42526207
Toxicologic test abnormal 26.03 18.39 11 33540 489 42587295
Drug ineffective for unapproved indication 25.87 18.39 3 33548 46160 42541624
Disorientation 25.87 18.39 75 33476 36314 42551470
Muscular weakness 25.78 18.39 17 33534 83481 42504303
Analgesic drug level increased 25.74 18.39 14 33537 1094 42586690
Pupil fixed 25.68 18.39 17 33534 1900 42585884
Alcoholic coma 25.62 18.39 7 33544 78 42587706
Thrombosis 25.47 18.39 11 33540 68500 42519284
Pneumonia aspiration 25.43 18.39 92 33459 49986 42537798
Respiratory acidosis 25.32 18.39 28 33523 6303 42581481
Coma scale abnormal 25.17 18.39 24 33527 4541 42583243
Prostate cancer 24.78 18.39 3 33548 44640 42543144
Influenza 24.73 18.39 9 33542 62166 42525618
Suicidal behaviour 23.90 18.39 15 33536 1531 42586253
Gastrointestinal disorder 23.87 18.39 4 33547 46649 42541135
Infusion related reaction 23.85 18.39 9 33542 60797 42526987
Gun shot wound 23.80 18.39 13 33538 1024 42586760
Shock 23.64 18.39 63 33488 29058 42558726
Amphetamines positive 23.35 18.39 8 33543 198 42587586
Deep vein thrombosis 23.31 18.39 16 33535 76941 42510843
Cardiac failure 23.23 18.39 30 33521 106826 42480958
Hospitalisation 23.12 18.39 15 33536 74315 42513469
Chills 23.05 18.39 24 33527 94042 42493742
Substance-induced mood disorder 23.02 18.39 6 33545 55 42587729
Upper respiratory tract infection 23 18.39 3 33548 42170 42545614
Therapeutic product effect incomplete 22.50 18.39 14 33537 70925 42516859
C-reactive protein increased 22.39 18.39 11 33540 63549 42524235
Visceral oedema 22.28 18.39 6 33545 63 42587721
Sinusitis 22.21 18.39 5 33546 47287 42540497
Substance use 22.19 18.39 15 33536 1736 42586048
Toxic leukoencephalopathy 22.09 18.39 11 33540 716 42587068
Hypersensitivity 21.98 18.39 15 33536 72355 42515429
Wheezing 21.66 18.39 8 33543 54773 42533011
Restlessness 21.48 18.39 61 33490 29188 42558596
Chemical submission 21.04 18.39 6 33545 79 42587705
Abdominal discomfort 21.04 18.39 17 33534 75238 42512546
Dysphagia 20.87 18.39 16 33535 72703 42515081
Leukopenia 20.76 18.39 17 33534 74729 42513055
Chronic obstructive pulmonary disease 20.66 18.39 12 33539 63102 42524682
Abdominal distension 20.32 18.39 16 33535 71719 42516065
Bronchitis 20.23 18.39 6 33545 47195 42540589
Sudden death 20.07 18.39 42 33509 16587 42571197
Paranoia 20.02 18.39 38 33513 13988 42573796
Psychiatric disorder prophylaxis 20.01 18.39 5 33546 38 42587746
Patient uncooperative 19.94 18.39 10 33541 661 42587123
Chemical poisoning 19.63 18.39 6 33545 102 42587682
Productive cough 19.62 18.39 8 33543 51559 42536225
Acute hepatic failure 19.31 18.39 42 33509 17031 42570753
Haematochezia 19.28 18.39 11 33540 58425 42529359
Sinus tachycardia 19.17 18.39 47 33504 20606 42567178
Electrocardiogram repolarisation abnormality 18.99 18.39 11 33540 970 42586814
Blood glucose increased 18.97 18.39 18 33533 73681 42514103
Drug diversion 18.93 18.39 11 33540 976 42586808
Injection site pain 18.90 18.39 11 33540 57787 42529997
Musculoskeletal stiffness 18.88 18.39 11 33540 57754 42530030
Drug reaction with eosinophilia and systemic symptoms 18.68 18.39 5 33546 42070 42545714
Postmortem blood drug level abnormal 18.51 18.39 8 33543 376 42587408
Erythema 18.48 18.39 36 33515 108757 42479027
Pneumonitis 18.44 18.39 5 33546 41713 42546071

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 8681.34 20.00 4944 150810 237437 110196108
Drug abuse 7192.76 20.00 3930 151824 173481 110260064
Toxicity to various agents 5376.95 20.00 4821 150933 475734 109957811
Cardio-respiratory arrest 1544.65 20.00 1290 154464 114546 110318999
Intentional overdose 1005.31 20.00 1080 154674 131421 110302124
Alcohol interaction 841.42 20.00 280 155474 3414 110430131
Suspected suicide 837.21 20.00 415 155339 14784 110418761
Substance use disorder 784.30 20.00 318 155436 6972 110426573
Exposure to toxic agent 655.03 20.00 333 155421 12525 110421020
Overdose 642.41 20.00 1168 154586 232626 110200919
Drug use disorder 635.48 20.00 366 155388 17708 110415837
Suicide attempt 534.68 20.00 693 155061 102701 110330844
Anaemia 534.20 20.00 70 155684 547016 109886529
Irritable bowel syndrome 532.60 20.00 883 154871 163332 110270213
Ill-defined disorder 532.48 20.00 861 154893 155992 110277553
Rheumatic fever 512.16 20.00 741 155013 121838 110311707
Intentional product misuse 511.55 20.00 773 154981 132131 110301414
Folliculitis 498.10 20.00 867 154887 166786 110266759
Helicobacter infection 483.41 20.00 896 154858 180981 110252564
Cough 480.87 20.00 47 155707 461594 109971951
Alcohol abuse 475.85 20.00 199 155555 4730 110428815
Muscle injury 456.33 20.00 757 154997 140050 110293495
Lip dry 450.51 20.00 627 155127 99456 110334089
Drug ineffective 444.81 20.00 925 154829 1519615 108913930
Facet joint syndrome 440.92 20.00 610 155144 96218 110337327
Injury 439.73 20.00 848 154906 176417 110257128
Type 2 diabetes mellitus 423.99 20.00 835 154919 176397 110257148
Joint range of motion decreased 410.96 20.00 667 155087 121165 110312380
Alcohol poisoning 408.85 20.00 216 155538 8804 110424741
Hand deformity 408.60 20.00 931 154823 217575 110215970
Duodenal ulcer perforation 406.84 20.00 822 154932 176878 110256667
Glossodynia 404.21 20.00 936 154818 221068 110212477
Neutropenia 398.44 20.00 35 155719 374585 110058960
Pemphigus 387.72 20.00 902 154852 213668 110219877
Impaired healing 386.62 20.00 855 154899 195862 110237683
Sleep disorder 384.35 20.00 858 154896 197786 110235759
Wound 376.95 20.00 942 154812 233495 110200050
Respiratory arrest 372.79 20.00 435 155319 57864 110375681
Sleep disorder due to general medical condition, insomnia type 366.69 20.00 586 155168 105057 110328488
Coma 363.64 20.00 620 155134 117249 110316296
Liver injury 362.55 20.00 711 155043 149702 110283843
C-reactive protein abnormal 358.43 20.00 650 155104 129045 110304500
Road traffic accident 358.15 20.00 585 155169 106813 110326732
Systemic lupus erythematosus 351.72 20.00 966 154788 253372 110180173
Pericarditis 350.73 20.00 879 154875 218235 110215310
Urinary tract infection 340.21 20.00 33 155721 326249 110107296
Substance abuse 338.84 20.00 214 155540 12249 110421296
Acute kidney injury 337.82 20.00 242 155512 635188 109798357
Constipation 334.46 20.00 52 155702 357734 110075811
Febrile neutropenia 333.02 20.00 31 155723 316736 110116809
Swollen joint count increased 332.34 20.00 494 155260 83167 110350378
Rheumatoid factor positive 327.88 20.00 631 155123 131009 110302536
Off label use 327.39 20.00 1057 154697 1499128 108934417
Psoriatic arthropathy 325.07 20.00 799 154955 195962 110237583
Diarrhoea 325.06 20.00 702 155052 1138803 109294742
Product dose omission issue 319.09 20.00 39 155715 321743 110111802
Fibromyalgia 315.84 20.00 725 155029 170184 110263361
Breast cancer stage III 304.03 20.00 460 155294 78657 110354888
Poisoning 301.10 20.00 281 155473 28824 110404721
Drug dependence 284.98 20.00 352 155402 49668 110383877
Sepsis 279.20 20.00 60 155694 327286 110106259
Peripheral venous disease 269.39 20.00 450 155304 83667 110349878
Deep vein thrombosis postoperative 266.04 20.00 371 155383 58920 110374625
Amnesia 265.81 20.00 508 155246 104900 110328645
Adjustment disorder with depressed mood 261.65 20.00 316 155438 43567 110389978
Victim of crime 260.79 20.00 91 155663 1292 110432253
Lupus vulgaris 259.80 20.00 278 155476 33605 110399940
Poisoning deliberate 258.58 20.00 247 155507 26084 110407461
Anti-cyclic citrullinated peptide antibody positive 256.22 20.00 696 155058 181288 110252257
X-ray abnormal 254.72 20.00 291 155463 37826 110395719
Dislocation of vertebra 254.44 20.00 311 155443 43410 110390135
Back pain 252.81 20.00 103 155651 370893 110062652
Synovitis 249.56 20.00 901 154853 273191 110160354
Erythema 247.35 20.00 54 155700 291393 110142152
COVID-19 247.14 20.00 28 155726 245032 110188513
Alcohol use 246.27 20.00 119 155635 4003 110429542
Hypercholesterolaemia 240.48 20.00 447 155307 90390 110343155
Bursitis 238.72 20.00 550 155204 129368 110304177
Lower respiratory tract infection 238.40 20.00 819 154935 242287 110191258
Lower limb fracture 235.83 20.00 399 155355 74949 110358596
Porphyria acute 229.14 20.00 199 155555 18581 110414964
Disease progression 229.05 20.00 35 155719 243999 110189546
Grip strength decreased 226.75 20.00 406 155348 79768 110353777
Nausea 221.56 20.00 943 154811 1234747 109198798
Night sweats 221.09 20.00 544 155210 133439 110300106
Wound infection 220.32 20.00 446 155308 96019 110337526
Blister 219.43 20.00 762 154992 226614 110206931
Asphyxia 218.02 20.00 172 155582 14043 110419502
Haemoglobin decreased 213.26 20.00 45 155709 248682 110184863
Obesity 212.81 20.00 484 155270 112867 110320678
White blood cell count decreased 210.55 20.00 35 155719 229355 110204190
Dehydration 210.14 20.00 66 155688 279445 110154100
Pancytopenia 206.28 20.00 26 155728 209587 110223958
Stomatitis 205.46 20.00 839 154915 269403 110164142
Pneumonia 200.15 20.00 604 155150 876110 109557435
Blood cholesterol increased 194.80 20.00 638 155116 184147 110249398
Sciatica 194.36 20.00 413 155341 91986 110341559
Onychomycosis 193.97 20.00 255 155499 38276 110395269
Autoimmune disorder 193.42 20.00 338 155416 65145 110368400
Platelet count decreased 190.90 20.00 45 155709 230398 110203147
Mobility decreased 190.78 20.00 750 155004 236672 110196873
Fatigue 189.53 20.00 976 154778 1214982 109218563
Cerebrovascular accident 187.14 20.00 19 155735 181265 110252280
Discomfort 187.09 20.00 696 155058 214011 110219534
Blood pressure increased 185.50 20.00 66 155688 258307 110175238
Liver disorder 185.34 20.00 529 155225 141714 110291831
Hepatic enzyme increased 185.17 20.00 918 154836 319974 110113571
Malignant neoplasm progression 183.61 20.00 17 155737 174550 110258995
Onychomadesis 183.25 20.00 271 155483 45392 110388153
Medication error 180.41 20.00 434 155320 104932 110328613
Pulmonary embolism 179.40 20.00 41 155713 214433 110219112
Intentional product use issue 179.28 20.00 758 154996 247148 110186397
Neuropathy peripheral 176.98 20.00 22 155732 179255 110254290
Retinitis 175.35 20.00 222 155532 32105 110401440
Renal impairment 174.61 20.00 28 155726 188417 110245128
Inflammation 169.67 20.00 628 155126 192610 110240935
Injection site pain 168.13 20.00 25 155729 177897 110255648
Fall 166.38 20.00 378 155376 603104 109830441
Rheumatoid arthritis 165.71 20.00 847 154907 298766 110134779
Dry mouth 160.90 20.00 632 155122 199316 110234229
Gait inability 160.32 20.00 489 155265 135887 110297658
Influenza 159.23 20.00 24 155730 169077 110264468
Septic shock 156.30 20.00 19 155735 157509 110276036
Hyponatraemia 155.54 20.00 56 155698 217597 110215948
Chills 152.44 20.00 40 155714 190540 110243005
Swelling 151.35 20.00 928 154826 350113 110083432
Blood alcohol increased 150.26 20.00 56 155698 970 110432575
Bone erosion 149.66 20.00 249 155505 46122 110387423
Lupus-like syndrome 149.37 20.00 232 155522 40560 110392985
Pulmonary fibrosis 148.28 20.00 395 155359 101647 110331898
Cardiac arrest 146.42 20.00 607 155147 196146 110237399
Aggression 146.32 20.00 283 155471 58927 110374618
Exostosis 145.95 20.00 245 155509 45711 110387834
Oropharyngeal pain 145.45 20.00 12 155742 135264 110298281
Interstitial lung disease 145.38 20.00 14 155740 139320 110294225
Chemical submission 144.29 20.00 47 155707 533 110433012
Miosis 143.78 20.00 166 155588 21817 110411728
Chest discomfort 141.90 20.00 35 155719 173813 110259732
Renal failure 141.60 20.00 71 155683 226503 110207042
Dyspnoea 141.10 20.00 947 154807 1105925 109327620
Mydriasis 141.04 20.00 165 155589 21992 110411553
Lung disorder 140.74 20.00 564 155190 179483 110254062
Herpes zoster 137.93 20.00 3 155751 108376 110325169
Cardiac failure congestive 136.42 20.00 24 155730 150976 110282569
Inappropriate schedule of product administration 134.68 20.00 59 155695 203578 110229967
Atrial fibrillation 133.27 20.00 79 155675 229563 110203982
Maternal exposure timing unspecified 132.96 20.00 156 155598 20857 110412688
Musculoskeletal pain 131.00 20.00 558 155196 182465 110251080
Prescribed overdose 130.27 20.00 342 155412 87239 110346306
Osteoarthritis 130.11 20.00 556 155198 182067 110251478
Laryngitis 129.26 20.00 222 155532 42189 110391356
C-reactive protein 128.94 20.00 185 155569 30146 110403399
Anti-cyclic citrullinated peptide antibody 127.63 20.00 149 155605 19815 110413730
Myocardial infarction 126.48 20.00 56 155698 192027 110241518
Grip strength 126.17 20.00 104 155650 9037 110424508
Syncope 125.76 20.00 64 155690 202472 110231073
Memory impairment 125.51 20.00 580 155174 196364 110237181
Pleural effusion 124.81 20.00 47 155707 177662 110255883
Thrombocytopenia 124.01 20.00 187 155567 348698 110084847
Haematochezia 122.14 20.00 11 155743 115513 110318032
Myalgia 121.48 20.00 82 155672 222299 110211246
Dysphagia 119.52 20.00 34 155720 153566 110279979
Colitis 119.10 20.00 6 155748 102317 110331228
Cardiac failure 118.43 20.00 58 155696 187568 110245977
Cellulitis 118.37 20.00 18 155736 125998 110307547
Ulcer haemorrhage 117.68 20.00 152 155602 22419 110411126
Neutrophil count decreased 116.57 20.00 16 155738 120925 110312620
Arthropathy 116.34 20.00 748 155006 286774 110146771
Gastrointestinal haemorrhage 115.87 20.00 44 155710 165474 110268071
Respiratory failure 115.50 20.00 81 155673 215251 110218294
Wheezing 114.56 20.00 682 155072 254548 110178997
Incorrect route of product administration 114.10 20.00 268 155486 63793 110369752
Gastrointestinal disorder 113.43 20.00 654 155100 241298 110192247
Nasal congestion 110.59 20.00 7 155747 98275 110335270
Blood creatinine increased 110.29 20.00 60 155694 182829 110250716
Live birth 110.22 20.00 278 155476 69206 110364339
Infusion related reaction 110.21 20.00 915 154839 380247 110053298
Contusion 110.19 20.00 632 155122 232729 110200816
Thrombosis 108.05 20.00 13 155741 108649 110324896
Prescription drug used without a prescription 107.65 20.00 77 155677 5419 110428126
Methaemoglobinaemia 107.53 20.00 95 155659 9073 110424472
Nail disorder 107.16 20.00 246 155508 57689 110375856
Productive cough 105.84 20.00 17 155737 114288 110319257
Dyspnoea exertional 104.59 20.00 12 155742 104048 110329497
Dry skin 104.33 20.00 14 155740 107639 110325906
Vision blurred 103.31 20.00 27 155727 128995 110304550
Feeling abnormal 102.28 20.00 64 155690 180647 110252898
Confusional state 102.20 20.00 1059 154695 467621 109965924
Deep vein thrombosis 101.62 20.00 35 155719 139852 110293693
Chronic obstructive pulmonary disease 101.60 20.00 16 155738 109142 110324403
Headache 101.54 20.00 777 154977 881600 109551945
Epistaxis 101.17 20.00 29 155725 130343 110303202
Respiratory depression 100.81 20.00 170 155584 31831 110401714
Maternal exposure during pregnancy 99.98 20.00 658 155096 254225 110179320
Injection site erythema 99.47 20.00 9 155745 94167 110339378
Contraindicated product administered 98.03 20.00 642 155112 247625 110185920
Dyspepsia 97.33 20.00 528 155226 190437 110243108
Palpitations 96.33 20.00 52 155702 159160 110274385
Rhinorrhoea 95.66 20.00 15 155739 102651 110330894
Accidental death 95.42 20.00 69 155685 4940 110428605
Hyperkalaemia 95.21 20.00 36 155718 135760 110297785
Delirium 94.54 20.00 409 155345 134616 110298929
Blood pressure systolic increased 93.11 20.00 6 155748 82985 110350560
Hypoaesthesia 92.77 20.00 758 154996 313465 110120080
Agitation 92.23 20.00 359 155395 112692 110320853
Blood pressure fluctuation 91.74 20.00 3 155751 74821 110358724
Cataract 91.44 20.00 5 155749 79480 110354065
Anaphylactic reaction 91.36 20.00 24 155730 114276 110319269
Therapeutic product effect decreased 91.18 20.00 623 155131 243693 110189852
Stress 90.38 20.00 19 155735 105329 110328216
Pyrexia 89.76 20.00 821 154933 897444 109536101
Insomnia 89.39 20.00 837 154917 359753 110073792
Drug ineffective for unapproved indication 89.35 20.00 18 155736 102820 110330725
Adverse event 89.15 20.00 346 155408 108463 110325082
Drug reaction with eosinophilia and systemic symptoms 89.03 20.00 7 155747 82088 110351457
Migraine 88.42 20.00 476 155278 171176 110262369
Angioedema 88.22 20.00 16 155738 98484 110335061
Walking aid user 88.18 20.00 140 155614 24935 110408610
Mucosal inflammation 87.45 20.00 15 155739 96126 110337419
Pregnancy 87.00 20.00 210 155544 50857 110382688
Hepatic cirrhosis 85.61 20.00 249 155505 67377 110366168
Subcutaneous drug absorption impaired 85.14 20.00 77 155677 7582 110425963
Skin exfoliation 83.52 20.00 12 155742 87639 110345906
Sinusitis 83.46 20.00 708 155046 295980 110137565
Rash maculo-papular 81.42 20.00 6 155748 74216 110359329
Cystitis 79.73 20.00 3 155751 66033 110367512
Prescribed underdose 79.66 20.00 237 155517 64937 110368608
Illness 78.88 20.00 11 155743 82160 110351385
Eczema 78.86 20.00 6 155748 72287 110361258
Dysgeusia 78.69 20.00 5 155749 69980 110363565
Blood glucose increased 77.67 20.00 45 155709 132451 110301094
Ascites 77.07 20.00 18 155736 92790 110340755
Death 77.02 20.00 1397 154357 697472 109736073
Pneumonitis 76.47 20.00 9 155745 76522 110357023
Blepharospasm 75.32 20.00 208 155546 54643 110378902
Alopecia 74.22 20.00 813 154941 363940 110069605
Adverse reaction 73.78 20.00 142 155612 29452 110404093
Chronic kidney disease 73.74 20.00 10 155744 76281 110357264
Cardiac disorder 73.72 20.00 10 155744 76270 110357275
Diabetes mellitus 73.69 20.00 24 155730 99357 110334188
Back injury 73.46 20.00 188 155566 47211 110386334
Plasma cell myeloma 72.27 20.00 4 155750 62932 110370613
Acute myocardial infarction 72.09 20.00 15 155739 83762 110349783
Hypothyroidism 71.79 20.00 9 155745 72890 110360655
Oedema 71.08 20.00 523 155231 209453 110224092
Dysphonia 70.95 20.00 11 155743 75918 110357627
Urticaria 70.62 20.00 723 155031 318134 110115411
Hypersensitivity 70.43 20.00 874 154880 403124 110030421
Swollen joint count 69.73 20.00 73 155681 8601 110424944
Foot deformity 69.73 20.00 187 155567 48293 110385252
Postmortem blood drug level abnormal 69.11 20.00 28 155726 612 110432933
Bone marrow failure 68.59 20.00 3 155751 57845 110375700
Leukopenia 68.54 20.00 65 155689 148726 110284819
Finger deformity 68.50 20.00 147 155607 32945 110400600
Asthenia 67.75 20.00 632 155122 688367 109745178
Rash erythematous 67.69 20.00 16 155738 81816 110351729
Haemoptysis 67.45 20.00 10 155744 71344 110362201
Bronchitis 67.32 20.00 73 155681 156959 110276586
Hip arthroplasty 66.36 20.00 201 155553 55612 110377933
Influenza like illness 66.18 20.00 21 155733 88391 110345154
Heart rate increased 66.06 20.00 63 155691 143771 110289774
Incorrect dose administered 65.45 20.00 32 155722 103609 110329936
General symptom 65.03 20.00 71 155683 8775 110424770
Hypocalcaemia 64.54 20.00 8 155746 65358 110368187
Alcohol withdrawal syndrome 64.04 20.00 39 155715 2091 110431454
Toxic epidermal necrolysis 63.94 20.00 4 155750 56723 110376822
Alanine aminotransferase increased 63.81 20.00 100 155654 183673 110249872
Alcoholism 63.72 20.00 48 155706 3659 110429886
Flushing 63.66 20.00 34 155720 104702 110328843
Abdominal pain 63.06 20.00 443 155311 512546 109920999
Drug eruption 62.91 20.00 3 155751 53656 110379889
Haemorrhage 62.87 20.00 36 155718 106656 110326889
Drug tolerance decreased 62.45 20.00 127 155627 27413 110406132
Injection site swelling 62.40 20.00 7 155747 61783 110371762
Agranulocytosis 62.37 20.00 7 155747 61753 110371792
Injection site pruritus 59.67 20.00 3 155751 51255 110382290
Diverticulitis 59.65 20.00 4 155750 53518 110380027
Victim of sexual abuse 59.65 20.00 24 155730 515 110433030
Weight decreased 59.60 20.00 400 155354 467657 109965888
Lymphocyte count decreased 59.05 20.00 6 155748 57237 110376308
Arthralgia 58.39 20.00 761 154993 778871 109654674
Angina pectoris 58.26 20.00 9 155745 62286 110371259
Cytomegalovirus infection 58.04 20.00 5 155749 54439 110379106
Heart rate decreased 57.90 20.00 22 155732 82734 110350811
Bone pain 57.42 20.00 11 155743 65122 110368423
Product label confusion 56.76 20.00 109 155645 22568 110410977
Product prescribing error 56.73 20.00 4 155750 51327 110382218
Pain 56.44 20.00 976 154778 953979 109479566
Red blood cell count decreased 56.32 20.00 12 155742 65911 110367634
Hyperhidrosis 55.92 20.00 112 155642 187186 110246359
Dysuria 55.66 20.00 9 155745 60222 110373323
Musculoskeletal stiffness 55.20 20.00 620 155134 279202 110154343
Haematuria 54.93 20.00 24 155730 82981 110350564
Balance disorder 54.76 20.00 50 155704 116510 110317035
Orthostatic hypotension 54.70 20.00 13 155741 66236 110367309
Dry eye 54.67 20.00 7 155747 55786 110377759
Nephrolithiasis 54.66 20.00 13 155741 66199 110367346
Suicidal ideation 54.25 20.00 269 155485 93668 110339877
Joint swelling 54.00 20.00 900 154854 441945 109991600
Stevens-Johnson syndrome 53.79 20.00 3 155751 46898 110386647
Pain in jaw 53.75 20.00 5 155749 51172 110382373
Swollen tongue 53.63 20.00 10 155744 60352 110373193
Skin ulcer 53.53 20.00 12 155742 63633 110369912
Presyncope 53.48 20.00 4 155750 48883 110384662
Hypercalcaemia 53.46 20.00 3 155751 46654 110386891
Ear infection 53.44 20.00 202 155552 62530 110371015
Hypotension 52.97 20.00 477 155277 523372 109910173
Hypokalaemia 52.86 20.00 111 155643 182337 110251208
Burning sensation 52.59 20.00 16 155738 69196 110364349
Breast cancer stage II 52.57 20.00 118 155636 27257 110406288
Blood pressure decreased 52.16 20.00 51 155703 115040 110318505
Pustular psoriasis 52.08 20.00 79 155675 13526 110420019
Disease recurrence 52.06 20.00 11 155743 60773 110372772
Upper respiratory tract infection 52.03 20.00 65 155689 131263 110302282
Transient ischaemic attack 51.96 20.00 13 155741 63969 110369576
Lymphadenopathy 51.79 20.00 13 155741 63822 110369723
Infection 51.33 20.00 755 154999 361445 110072100
Oral candidiasis 50.92 20.00 3 155751 44757 110388788
Fungal infection 50.70 20.00 6 155748 50800 110382745
Hot flush 50.66 20.00 15 155739 66021 110367524
Vertigo 50.21 20.00 30 155724 86840 110346705
Drug screen positive 49.84 20.00 53 155701 6357 110427188
Therapy interrupted 49.43 20.00 6 155748 49816 110383729
Anaphylactic shock 49.24 20.00 7 155747 51539 110382006
Blood ethanol increased 49.16 20.00 22 155732 619 110432926
Bradycardia 49.04 20.00 90 155664 155427 110278118
Melaena 48.57 20.00 18 155736 68739 110364806
Aspartate aminotransferase increased 48.29 20.00 95 155659 159841 110273704
Abdominal discomfort 48.21 20.00 801 154953 393057 110040488
Swelling face 47.82 20.00 36 155718 92285 110341260
Blood ethanol 47.66 20.00 14 155740 109 110433436
Upper gastrointestinal haemorrhage 47.40 20.00 7 155747 50089 110383456
Pulmonary hypertension 47.28 20.00 10 155744 55210 110378335
Muscle spasms 47.24 20.00 599 155155 277558 110155987
Clostridium difficile colitis 46.73 20.00 4 155750 43774 110389771
Joint dislocation 46.29 20.00 129 155625 34061 110399484
Limb discomfort 45.69 20.00 3 155751 40851 110392694
Intentional self-injury 45.63 20.00 136 155618 37293 110396252
Skin disorder 45.59 20.00 4 155750 42909 110390636
Therapy cessation 45.51 20.00 5 155749 44852 110388693
Coronary artery disease 45.47 20.00 22 155732 71668 110361877
Victim of chemical submission 45.45 20.00 23 155731 856 110432689
Multiple sclerosis relapse 45.33 20.00 8 155746 50232 110383313
Wrong technique in product usage process 45.32 20.00 34 155720 87314 110346231
Postmortem blood drug level 45.17 20.00 17 155737 303 110433242
Multiple organ dysfunction syndrome 45.04 20.00 91 155663 151619 110281926
Lymphopenia 44.77 20.00 3 155751 40167 110393378
Weight increased 44.08 20.00 833 154921 418811 110014734
Hypomagnesaemia 44.02 20.00 15 155739 60355 110373190
Opiates positive 44.01 20.00 23 155731 916 110432629
Lip swelling 43.74 20.00 9 155745 50658 110382887
Rash vesicular 43.73 20.00 76 155678 14576 110418969
Ischaemic stroke 43.42 20.00 4 155750 41259 110392286
Throat irritation 43.26 20.00 11 155743 53541 110380004
Bradypnoea 43.15 20.00 57 155697 8592 110424953
Haematocrit decreased 42.37 20.00 20 155734 66097 110367448
Bacteraemia 42.31 20.00 5 155749 42385 110391160
Respiratory tract infection 41.01 20.00 25 155729 71592 110361953
Abdominal pain lower 40.93 20.00 3 155751 37280 110396265
Viral infection 40.89 20.00 12 155742 53127 110380418
Nasopharyngitis 40.79 20.00 781 154973 393580 110039965
Localised infection 40.76 20.00 6 155748 43042 110390503
Mouth ulceration 40.64 20.00 9 155745 48129 110385416
Behavioural addiction 40.50 20.00 11 155743 62 110433483
Knee arthroplasty 40.39 20.00 190 155564 64758 110368787
Hypervolaemia 40.26 20.00 10 155744 49450 110384095
Frequent bowel movements 40.21 20.00 203 155551 71187 110362358
Gastroenteritis 40.20 20.00 4 155750 38796 110394749
Bacterial infection 40.11 20.00 8 155746 46028 110387517
Disability 39.91 20.00 113 155641 30110 110403435
Electrocardiogram QRS complex prolonged 39.46 20.00 68 155686 12953 110420592
Cerebral infarction 39.35 20.00 12 155742 51826 110381719
Withdrawal syndrome 39.19 20.00 115 155639 31265 110402280
Skin lesion 39.11 20.00 12 155742 51619 110381926
Neuralgia 39.08 20.00 10 155744 48468 110385077
Vasculitis 39.06 20.00 3 155751 35870 110397675
Amphetamines positive 38.82 20.00 15 155739 288 110433257
Haemorrhoids 38.79 20.00 3 155751 35669 110397876
Tubulointerstitial nephritis 38.70 20.00 14 155740 54270 110379275
Limb injury 38.68 20.00 4 155750 37632 110395913
Ulcer 38.61 20.00 7 155747 43109 110390436
Neoplasm malignant 38.04 20.00 4 155750 37139 110396406
COVID-19 pneumonia 38.04 20.00 4 155750 37139 110396406
Flatulence 37.95 20.00 13 155741 52136 110381409
Therapy partial responder 37.93 20.00 4 155750 37057 110396488
Homicide 37.81 20.00 22 155732 1084 110432461
Tinnitus 37.75 20.00 19 155735 60521 110373024
Red blood cell sedimentation rate increased 37.53 20.00 213 155541 78089 110355456
Neurotoxicity 37.48 20.00 7 155747 42200 110391345
Osteomyelitis 37.33 20.00 4 155750 36596 110396949
Diabetic ketoacidosis 37.29 20.00 7 155747 42051 110391494
Drug-induced liver injury 37.21 20.00 293 155461 119774 110313771
Diplopia 37.09 20.00 7 155747 41887 110391658
Hyperglycaemia 37.08 20.00 39 155715 85051 110348494
Movement disorder 37.08 20.00 4 155750 36400 110397145
Heart rate irregular 36.94 20.00 3 155751 34271 110399274
Exposure during pregnancy 36.72 20.00 379 155375 167045 110266500
Oral herpes 36.66 20.00 4 155750 36076 110397469
Candida infection 36.65 20.00 11 155743 47998 110385547
Hepatic function abnormal 36.64 20.00 43 155711 89252 110344293
Cholelithiasis 36.51 20.00 22 155732 63400 110370145
Epilepsy 36.43 20.00 254 155500 99955 110333590
Inappropriate antidiuretic hormone secretion 36.39 20.00 3 155751 33848 110399697
Lung neoplasm malignant 36.37 20.00 3 155751 33839 110399706
Unevaluable event 36.32 20.00 19 155735 59208 110374337
Urinary retention 36.31 20.00 27 155727 69656 110363889
Device related infection 36.30 20.00 6 155748 39513 110394032
Skin discolouration 36.08 20.00 12 155742 49034 110384511
Dizziness 36.07 20.00 730 155024 697463 109736082
Acne 35.95 20.00 3 155751 33517 110400028
Pulmonary mass 35.78 20.00 5 155749 37296 110396249
Drug abuser 35.63 20.00 41 155713 5368 110428177
Back disorder 35.59 20.00 86 155668 20836 110412709
Weight fluctuation 35.52 20.00 89 155665 22056 110411489
Tachycardia 35.52 20.00 481 155273 226164 110207381
Haematoma 35.50 20.00 19 155735 58457 110375088
Condition aggravated 35.42 20.00 777 154977 734059 109699486
Cerebral haemorrhage 35.40 20.00 24 155730 64944 110368601
Rash macular 35.26 20.00 6 155748 38680 110394865
Hypophagia 35.17 20.00 15 155739 52611 110380934
Gastritis 34.79 20.00 16 155738 53683 110379862
Taste disorder 34.79 20.00 183 155571 65204 110368341
Joint injury 34.74 20.00 7 155747 39987 110393558
Obstructive airways disorder 34.47 20.00 11 155743 46138 110387407
C-reactive protein increased 34.36 20.00 463 155291 217456 110216089
Oxygen saturation decreased 34.34 20.00 110 155644 156872 110276673
Laboratory test abnormal 34.34 20.00 138 155616 43941 110389604
Colitis ulcerative 34.19 20.00 206 155548 77157 110356388
Staphylococcal infection 34.06 20.00 29 155725 69915 110363630
Blood pressure diastolic decreased 33.98 20.00 5 155749 35880 110397665
Polyneuropathy 33.96 20.00 3 155751 32009 110401536
Eye pain 33.93 20.00 14 155740 50085 110383460
Device dislocation 33.56 20.00 3 155751 31701 110401844
Iron deficiency anaemia 33.37 20.00 3 155751 31556 110401989
International normalised ratio increased 33.28 20.00 44 155710 86728 110346817
Alcohol intolerance 33.19 20.00 15 155739 432 110433113
Metastases to bone 33.12 20.00 3 155751 31369 110402176
Normal newborn 33.05 20.00 86 155668 21810 110411735
Proteinuria 32.75 20.00 8 155746 40010 110393535
Gastric ulcer 32.52 20.00 8 155746 39819 110393726
Generalised oedema 32.24 20.00 3 155751 30701 110402844
Nodule 32.20 20.00 4 155750 32627 110400918
Peritonitis 32.17 20.00 4 155750 32603 110400942
Blood calcium decreased 31.71 20.00 6 155748 35839 110397706
Small intestinal obstruction 31.66 20.00 4 155750 32209 110401336
Depressed level of consciousness 31.56 20.00 268 155486 112010 110321535
Posterior reversible encephalopathy syndrome 31.42 20.00 5 155749 33856 110399689
Conjunctivitis 31.33 20.00 5 155749 33787 110399758
Eye injury 31.07 20.00 46 155708 7709 110425836
Eye irritation 30.90 20.00 5 155749 33447 110400098
Hypoacusis 30.90 20.00 6 155748 35185 110398360
Hip fracture 30.85 20.00 6 155748 35145 110398400
Gastric disorder 30.78 20.00 5 155749 33352 110400193
Gout 30.54 20.00 7 155747 36559 110396986
Bronchiectasis 30.45 20.00 7 155747 36486 110397059
Gastroenteritis viral 30.39 20.00 4 155750 31222 110402323
Blood urea increased 30.35 20.00 20 155734 54937 110378608
Renal disorder 30.15 20.00 16 155738 49463 110384082
Pericardial effusion 30.03 20.00 22 155732 57195 110376350
Treatment failure 30.01 20.00 553 155201 276681 110156864
Tumour lysis syndrome 29.85 20.00 4 155750 30797 110402748
Neutropenic sepsis 29.78 20.00 4 155750 30742 110402803
Analgesic drug level increased 29.58 20.00 32 155722 3914 110429631
Toxicologic test abnormal 29.55 20.00 20 155734 1287 110432258
Blood alkaline phosphatase increased 29.27 20.00 34 155720 70901 110362644
Breast cancer 29.12 20.00 9 155745 38533 110395012
General physical health deterioration 28.61 20.00 793 154961 424502 110009043
Blindness 28.36 20.00 8 155746 36351 110397194
Toxic skin eruption 28.08 20.00 3 155751 27512 110406033
Coeliac disease 28.08 20.00 128 155626 43059 110390486
Labelled drug-drug interaction medication error 27.94 20.00 4 155750 29298 110404247
Premature delivery 27.37 20.00 5 155749 30627 110402918
Impaired driving ability 27.29 20.00 39 155715 6331 110427214
Body temperature decreased 27.24 20.00 9 155745 36926 110396619
Metastases to liver 27.21 20.00 8 155746 35378 110398167
Drug withdrawal syndrome 27.18 20.00 116 155638 37938 110395607
Tremor 27.13 20.00 170 155584 202062 110231483
Jaundice 27.13 20.00 26 155728 59210 110374335
Osteonecrosis 27.12 20.00 7 155747 33734 110399811
Blood test abnormal 26.99 20.00 4 155750 28550 110404995
Blood potassium decreased 26.89 20.00 22 155732 54092 110379453
Blood bilirubin increased 26.68 20.00 41 155713 75931 110357614
Cholestasis 26.54 20.00 31 155723 64487 110369058
Hypophosphataemia 26.45 20.00 7 155747 33175 110400370
Diabetes mellitus inadequate control 26.31 20.00 5 155749 29770 110403775
Eye swelling 26.29 20.00 7 155747 33041 110400504
Behaviour disorder 26.17 20.00 48 155706 9599 110423946
Tooth disorder 25.98 20.00 5 155749 29504 110404041
Delirium tremens 25.84 20.00 15 155739 736 110432809
Depression 25.83 20.00 607 155147 316728 110116817
Sleep disorder due to a general medical condition 25.79 20.00 143 155611 51969 110381576
Product use issue 25.61 20.00 597 155157 311098 110122447
Feeling cold 25.56 20.00 8 155746 33979 110399566
Device malfunction 25.55 20.00 3 155751 25555 110407990
Cognitive disorder 25.54 20.00 53 155701 87458 110346087
Underdose 25.44 20.00 165 155589 63389 110370156
Paraesthesia oral 25.19 20.00 8 155746 33663 110399882
Progressive multifocal leukoencephalopathy 24.77 20.00 3 155751 24953 110408592
Appendicitis 24.68 20.00 5 155749 28459 110405086
Hepatocellular injury 24.66 20.00 21 155733 50621 110382924
Aphasia 24.65 20.00 28 155726 58969 110374576
Pallor 24.47 20.00 26 155728 56441 110377104
Injection site haemorrhage 24.44 20.00 8 155746 33020 110400525
Dysstasia 24.39 20.00 8 155746 32978 110400567
Troponin increased 24.26 20.00 6 155748 29760 110403785
Aplastic anaemia 23.94 20.00 3 155751 24305 110409240
Faeces discoloured 23.79 20.00 9 155745 33939 110399606
Intervertebral disc protrusion 23.74 20.00 5 155749 27693 110405852
Postmortem blood drug level increased 23.72 20.00 17 155737 1200 110432345
Hyperthyroidism 23.65 20.00 6 155748 29255 110404290
Hiatus hernia 23.63 20.00 5 155749 27601 110405944
Hypothermia 23.49 20.00 86 155668 26216 110407329
Protein C increased 23.34 20.00 7 155747 59 110433486
Hypoalbuminaemia 23.31 20.00 6 155748 28968 110404577
Cardiomyopathy 23.30 20.00 9 155745 33516 110400029
Escherichia infection 23.30 20.00 3 155751 23813 110409732
Glomerular filtration rate decreased 23.29 20.00 6 155748 28950 110404595
Kidney infection 23.26 20.00 4 155750 25595 110407950
Dermatitis atopic 23.19 20.00 4 155750 25537 110408008
Injection site reaction 23.15 20.00 209 155545 88861 110344684
Hemiparesis 22.89 20.00 17 155737 43886 110389659
Surgery 22.83 20.00 15 155739 41268 110392277
Injection site rash 22.79 20.00 3 155751 23416 110410129
Pancreatitis acute 22.67 20.00 31 155723 60243 110373302
Blood sodium decreased 22.47 20.00 13 155741 38306 110395239
Metastases to lung 22.34 20.00 3 155751 23060 110410485
Liver function test increased 22.12 20.00 206 155548 88342 110345203
Pneumothorax 22.11 20.00 11 155743 35274 110398271
Ocular hyperaemia 22.10 20.00 14 155740 39272 110394273
Altered state of consciousness 22.09 20.00 148 155606 57478 110376067
Pancreatitis 22.08 20.00 215 155539 93318 110340227
Myocardial fibrosis 22.06 20.00 20 155734 1975 110431570
Sleep apnoea syndrome 21.96 20.00 15 155739 40432 110393113
Paraesthesia 21.91 20.00 527 155227 275994 110157551
Feeling hot 21.79 20.00 210 155544 90896 110342649
Hypertensive crisis 21.73 20.00 4 155750 24368 110409177
Glaucoma 21.64 20.00 3 155751 22514 110411031
Gamma-glutamyltransferase increased 21.62 20.00 33 155721 61276 110372269
Right ventricular failure 21.61 20.00 5 155749 25949 110407596
Acute respiratory failure 21.61 20.00 46 155708 75214 110358331
Atrial flutter 21.59 20.00 4 155750 24258 110409287
Photophobia 21.39 20.00 5 155749 25766 110407779
Adverse drug reaction 21.29 20.00 235 155519 105324 110328221
Hyperlipidaemia 21.25 20.00 12 155742 35836 110397709
Shock haemorrhagic 21.24 20.00 6 155748 27241 110406304
Abortion spontaneous 21.02 20.00 11 155743 34271 110399274
Blood lactate dehydrogenase increased 20.84 20.00 19 155735 44315 110389230
Alcoholic coma 20.84 20.00 7 155747 88 110433457
Neuroleptic malignant syndrome 20.77 20.00 11 155743 34048 110399497
Haematemesis 20.66 20.00 32 155722 59076 110374469
Vaginal haemorrhage 20.54 20.00 5 155749 25069 110408476
Peripheral swelling 20.46 20.00 728 155026 403306 110030239
Rib fracture 20.46 20.00 11 155743 33759 110399786
Drug interaction 20.45 20.00 542 155212 499641 109933904
Poor quality sleep 20.43 20.00 7 155747 28070 110405475
Substance abuser 20.43 20.00 11 155743 466 110433079
Petechiae 20.42 20.00 4 155750 23313 110410232
Product quality issue 20.41 20.00 182 155572 77117 110356428
Lacrimation increased 20.40 20.00 9 155745 30941 110402604
Blood uric acid increased 20.38 20.00 3 155751 21526 110412019
Immunodeficiency 20.30 20.00 15 155739 38823 110394722
Impaired work ability 20.26 20.00 6 155748 26413 110407132
Chromaturia 20.21 20.00 8 155746 29352 110404193
Fracture 20.20 20.00 5 155749 24783 110408762
Emotional distress 20.17 20.00 20 155734 44827 110388718
Ileus 20.15 20.00 9 155745 30720 110402825
Cardiac murmur 20.00 20.00 5 155749 24623 110408922

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AX05 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Other antiseptics and disinfectants
MeSH PA D012997 Solvents
CHEBI has role CHEBI:48356 protogenic solvent

Related Drugs by ATC class:

D08AX Other antiseptics and disinfectants 7 drugs
eosinethanolhydrogen peroxidepotassium permanganatepropanolsodium hypochloritetosylchloramide sodium

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004
Nausea and vomiting off-label use 16932000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
2%;70% (10.5ML) CHLORAPREP WITH TINT BECTON DICKINSON CO N020832 April 3, 2006 OTC SPONGE TOPICAL 7422388 April 25, 2027 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (26ML) CHLORAPREP WITH TINT BECTON DICKINSON CO N020832 May 3, 2005 OTC SPONGE TOPICAL 7422388 April 25, 2027 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (3ML) CHLORAPREP WITH TINT BECTON DICKINSON CO N020832 Oct. 10, 2006 OTC SPONGE TOPICAL 7422388 April 25, 2027 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 OTC SOLUTION TOPICAL 9629368 May 23, 2028 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 OTC SOLUTION TOPICAL 8389583 Aug. 9, 2029 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 OTC SOLUTION TOPICAL 10688291 Dec. 20, 2034 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 OTC SOLUTION TOPICAL 9844654 April 24, 2036 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2%;70% SOLUPREP S SOLVENTUM N208288 Aug. 8, 2018 OTC SOLUTION TOPICAL Jan. 20, 2026 REVISIONS TO THE LABELING TO DESCRIBE MODIFIED FORMULATION BASED ON RESULTS OF STUDIES EM-05-014624 AND EM-05-014815

Bioactivity Summary:

None

External reference:

IDSource
4018437 VUID
N0000146763 NUI
D00137 KEGG_DRUG
4017589 VANDF
4018437 VANDF
CHEBI:17824 CHEBI
IPA PDB_CHEM_ID
CHEMBL582 ChEMBL_ID
DB02325 DRUGBANK_ID
797541 RXNORM
11314 MMSL
4930 MMSL
002465 NDDF
259268001 SNOMEDCT_US
414547000 SNOMEDCT_US
C0022237 UMLSCUI
D019840 MESH_DESCRIPTOR_UI
3776 PUBCHEM_CID
ND2M416302 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Swim-EAR HUMAN OTC DRUG LABEL 1 0168-0126 SOLUTION 950 mg AURICULAR (OTIC) OTC Monograph Drug 12 sections
Hibistat HUMAN OTC DRUG LABEL 2 0234-0587 SOLUTION 70 g TOPICAL NDA 13 sections
Isopropyl alcohol70 percent HUMAN OTC DRUG LABEL 1 0363-0275 LIQUID 70 mL TOPICAL OTC Monograph Drug 13 sections
Isopropyl alcohol91 percent HUMAN OTC DRUG LABEL 1 0363-0277 LIQUID 91 mL TOPICAL OTC Monograph Drug 12 sections
Walgreens 70% Isopropyl Alcohol HUMAN OTC DRUG LABEL 1 0363-0380 LIQUID 0.70 mL TOPICAL OTC Monograph Drug 14 sections
Walgreens 91% Isopropyl Alcohol HUMAN OTC DRUG LABEL 1 0363-0381 LIQUID 0.91 mL TOPICAL OTC Monograph Drug 13 sections
Isopropyl alcohol70 percent HUMAN OTC DRUG LABEL 1 0363-0472 LIQUID 70 mL TOPICAL OTC Monograph Drug 12 sections
Isopropyl Alcohol HUMAN OTC DRUG LABEL 1 0363-0804 LIQUID 91 mL TOPICAL OTC Monograph Drug 16 sections
Walgreen Alcohol HUMAN OTC DRUG LABEL 1 0363-0809 SWAB 70 mL TOPICAL OTC Monograph Drug 13 sections
70% HUMAN OTC DRUG LABEL 1 0363-0810 LIQUID 70 mL TOPICAL OTC Monograph Drug 16 sections
70% Rubbing HUMAN OTC DRUG LABEL 1 0363-0845 LIQUID 70 mL TOPICAL OTC Monograph Drug 15 sections
EAR DRY DROPSWELL AT WALGREENS HUMAN OTC DRUG LABEL 1 0363-3019 LIQUID 95.00 1 AURICULAR (OTIC) OTC monograph final 11 sections
Walgreens Swimmers Ear HUMAN OTC DRUG LABEL 1 0363-6107 LIQUID 95 g TOPICAL OTC Monograph Drug 8 sections
Walgreens 70% Isopropyl Alcohol Wipes HUMAN OTC DRUG LABEL 1 0363-6505 CLOTH 70 mL TOPICAL OTC Monograph Drug 13 sections
HUMCO Ear Drops for Swimmers HUMAN OTC DRUG LABEL 1 0395-0098 LIQUID 950 mg AURICULAR (OTIC) OTC Monograph Drug 14 sections
HUMCO 1 Percent Iodine HUMAN OTC DRUG LABEL 1 0395-1211 LIQUID 700 mg TOPICAL OTC Monograph Drug 11 sections
HUMCO Isopropyl Rubbing Alcohol 70% HUMAN OTC DRUG LABEL 1 0395-1249 LIQUID 700 mg TOPICAL OTC Monograph Drug 13 sections
HUMCO Isopropyl Rubbing Alcohol 70% Professional Pack HUMAN OTC DRUG LABEL 1 0395-4202 LIQUID 700 mg TOPICAL OTC Monograph Drug 13 sections
Ear Drops for Swimmers HUMAN OTC DRUG LABEL 1 0395-9103 LIQUID 950 mg AURICULAR (OTIC) OTC monograph final 15 sections
Isopropyl Alcohol 91 Percent HUMAN OTC DRUG LABEL 1 0395-9119 LIQUID 910 mg TOPICAL OTC monograph not final 13 sections
Isopropyl Rubbing Alcohol 70 Percent HUMAN OTC DRUG LABEL 1 0395-9120 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
Isopropyl Alcohol 70 Percent With Wintergreen Oil HUMAN OTC DRUG LABEL 1 0395-9121 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
Isopropyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0404-0002 SOLUTION 700 mg TOPICAL OTC Monograph Drug 14 sections
Alcohol Prep Pads HUMAN OTC DRUG LABEL 1 0404-0007 SWAB 70 mL TOPICAL OTC Monograph Drug 11 sections
Alcohol Prep Pads HUMAN OTC DRUG LABEL 1 0404-0007 SWAB 70 mL TOPICAL OTC Monograph Drug 11 sections
Alcohol Prep Pads HUMAN OTC DRUG LABEL 1 0404-0103 SWAB 70 mL TOPICAL OTC Monograph Drug 9 sections
Alcohol Prep Pads HUMAN OTC DRUG LABEL 1 0404-0103 SWAB 70 mL TOPICAL OTC Monograph Drug 9 sections
Alcohol Prep Pad Large Pad HUMAN OTC DRUG LABEL 1 0404-9406 CLOTH 0.70 mL TOPICAL OTC Monograph Drug 10 sections
Alcohol Prep Pad Medium Pad HUMAN OTC DRUG LABEL 1 0404-9407 CLOTH 0.70 mL TOPICAL OTC Monograph Drug 10 sections
Alcohol Prep Pad Medium Pad HUMAN OTC DRUG LABEL 1 0404-9408 CLOTH 70 mL TOPICAL OTC Monograph Drug 10 sections