acetic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4211 64-19-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetic acid
  • acetic acid, glacial
  • ethanoic acid
  • ethylic acid
  • vinegar acid
Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
  • Molecular weight: 60.05
  • Formula: C2H4O2
  • CLOGP: -0.19
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: 0.73
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 17, 1960 FDA HI TECH PHARMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 20.08 0 4 6 21030 2337045

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC G01AD02 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Organic acids
ATC S02AA10 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D007202 Indicators and Reagents
CHEBI has role CHEBI:64049 food acidity regulator
CHEBI has role CHEBI:48356 protic solvent
CHEBI has role CHEBI:65256 antimicrobial food preservative

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Otalgia off-label use 16001004
Impacted cerumen off-label use 18070006
Otitis Externa Eczema off-label use
Otitis Externa Seborrhea off-label use
Herpes zoster auricularis contraindication 21954000 DOID:9210
Perforation of tympanic membrane contraindication 60442001
Herpes simplex contraindication 88594005 DOID:8566
Tuberculosis of ear contraindication 186269001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Infective otitis media contraindication 312218008
Porphyria contraindication 418470004
Sensation Disturbance of Genitals contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosine-protein kinase Fyn Kinase Kd 6.05 CHEMBL
Tyrosine-protein kinase Lck Kinase Kd 6.19 CHEMBL
Free fatty acid receptor 2 GPCR AGONIST EC50 4.60 IUPHAR

External reference:

IDSource
4018456 VUID
N0000146780 NUI
C0000983 UMLSCUI
D00010 KEGG_DRUG
326289007 SNOMEDCT_US
772941001 SNOMEDCT_US
786281009 SNOMEDCT_US
d04228 MMSL
11539 MMSL
4017443 VANDF
4018456 VANDF
422082008 SNOMEDCT_US
002875 NDDF
822 MMSL
168 RXNORM
4122 MMSL
2869004 SNOMEDCT_US
9812 MMSL
002917 NDDF
CHEMBL539 ChEMBL_ID
Q40Q9N063P UNII
ACY PDB_CHEM_ID
DB03166 DRUGBANK_ID
CHEBI:15366 CHEBI
1058 IUPHAR_LIGAND_ID
D019342 MESH_DESCRIPTOR_UI
176 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0264-2304 IRRIGANT 0.25 g IRRIGATION NDA 13 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0338-0656 IRRIGANT 250 mg IRRIGATION NDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0409-6143 IRRIGANT 250 mg IRRIGATION NDA 12 sections
Fem pH HUMAN PRESCRIPTION DRUG LABEL 2 0813-0799 JELLY 0.01 g VAGINAL unapproved drug other 12 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0990-6143 IRRIGANT 250 mg IRRIGATION NDA 12 sections
acetic acid HUMAN PRESCRIPTION DRUG LABEL 1 21695-222 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
acetic acid HUMAN PRESCRIPTION DRUG LABEL 1 50090-0351 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50383-889 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
hydrocortisone and acetic acid HUMAN PRESCRIPTION DRUG LABEL 2 50383-901 SOLUTION 20.75 mg AURICULAR (OTIC) NDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50436-4600 SOLUTION 20 mg AURICULAR (OTIC) ANDA 10 sections
Hydrocortisone and Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 2 51672-3007 SOLUTION 20.80 mg AURICULAR (OTIC) ANDA 11 sections
RELEGARD HUMAN PRESCRIPTION DRUG LABEL 2 51674-0130 GEL 0.90 mg TOPICAL unapproved drug other 2 sections
acetic acid HUMAN PRESCRIPTION DRUG LABEL 1 55045-1243 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
acetic acid HUMAN PRESCRIPTION DRUG LABEL 1 55700-424 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 10 sections
ACETIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 60432-741 SOLUTION 20 mg AURICULAR (OTIC) ANDA 10 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 64980-424 SOLUTION 20 mg AURICULAR (OTIC) ANDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68071-1739 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68071-3304 SOLUTION 20 mg AURICULAR (OTIC) ANDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68788-7231 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
ICEKING Skin Expert Anti-onychomycosis Gel HUMAN OTC DRUG LABEL 2 72501-072 GEL 2 g CUTANEOUS Export only 7 sections