cyanocobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4196 68-19-9

Description:

MoleculeDescription

Synonyms:

  • cyanocobalamin
  • vitamin B12
  • cobamin
  • cyanocobalamine
  • Molecular weight: 1355.39
  • Formula: C63H88CoN14O14P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 512.50
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
70 mcg N
1 mg O
20 mcg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 12.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Sept. 15, 1949 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1252.20 10.29 3875 546015 153337 55588840
Systemic lupus erythematosus 1162.53 10.29 4134 545756 175944 55566233
Rheumatoid arthritis 1091.39 10.29 6923 542967 375681 55366496
Glossodynia 1036.48 10.29 3561 546329 148897 55593280
Completed suicide 985.95 10.29 87 549803 133746 55608431
Hand deformity 813.46 10.29 3024 546866 131468 55610709
Toxicity to various agents 805.23 10.29 610 549280 223954 55518223
Alopecia 776.73 10.29 5214 544676 288244 55453933
Abdominal discomfort 772.31 10.29 4990 544900 272284 55469893
Arthropathy 763.58 10.29 3919 545971 196356 55545821
Wound 676.57 10.29 2918 546972 135886 55606291
Maternal exposure during pregnancy 609.00 10.29 3541 546349 186012 55556165
Pericarditis 516.91 10.29 2272 547618 106651 55635526
Discomfort 512.16 10.29 2734 547156 139027 55603150
Synovitis 511.22 10.29 3003 546887 158302 55583875
Infusion related reaction 511.02 10.29 3643 546247 205288 55536889
Anti-cyclic citrullinated peptide antibody positive 501.21 10.29 2100 547790 96500 55645677
Drug interaction 494.26 10.29 804 549086 208951 55533226
Swelling 464.20 10.29 3960 545930 235811 55506366
Drug abuse 461.70 10.29 58 549832 67552 55674625
Pain 436.40 10.29 8980 540910 654204 55087973
Contraindicated product administered 427.18 10.29 3199 546691 183087 55559090
Joint swelling 427.08 10.29 4517 545373 285283 55456894
Death 422.29 10.29 1808 548082 339618 55402559
Intentional overdose 370.53 10.29 103 549787 68014 55674163
Product use issue 324.35 10.29 3004 546886 183037 55559140
Arthralgia 308.88 10.29 6731 543159 494938 55247239
Duodenal ulcer perforation 302.62 10.29 1397 548493 66945 55675232
Rheumatoid factor positive 302.35 10.29 1407 548483 67653 55674524
Helicobacter infection 296.35 10.29 1459 548431 71809 55670368
Overdose 276.90 10.29 377 549513 105453 55636724
Febrile neutropenia 266.17 10.29 386 549504 105159 55637018
Suicide attempt 257.69 10.29 121 549769 57715 55684462
Hepatic enzyme increased 256.98 10.29 2682 547208 168702 55573475
Acute kidney injury 248.97 10.29 1358 548532 239405 55502772
Cardiac arrest 232.38 10.29 301 549589 86013 55656164
Musculoskeletal stiffness 214.18 10.29 2399 547491 153608 55588569
Fatigue 212.26 10.29 9566 540324 778986 54963191
Depressed level of consciousness 203.58 10.29 152 549738 56281 55685896
Nasopharyngitis 201.99 10.29 3155 546735 217804 55524373
Drug hypersensitivity 195.71 10.29 1732 548158 273473 55468704
Malignant neoplasm progression 193.60 10.29 261 549629 73326 55668851
Electrocardiogram QT prolonged 184.40 10.29 157 549733 54431 55687746
Psoriatic arthropathy 177.34 10.29 1285 548605 72723 55669454
Therapeutic product effect decreased 176.91 10.29 2476 547414 166976 55575201
Hip arthroplasty 174.24 10.29 794 549096 37829 55704348
Neutropenia 168.43 10.29 883 549007 157284 55584893
Knee arthroplasty 166.70 10.29 864 549026 43395 55698782
Device expulsion 163.78 10.29 47 549843 30402 55711775
Hypotension 163.26 10.29 1611 548279 248897 55493280
Disease progression 155.58 10.29 517 549373 104656 55637521
Drug intolerance 154.35 10.29 3528 546362 261290 55480887
Lactic acidosis 154.31 10.29 76 549814 35270 55706907
Exposure during pregnancy 153.67 10.29 2020 547870 134322 55607855
Sedation 152.07 10.29 75 549815 34779 55707398
Hyponatraemia 151.15 10.29 502 549388 101637 55640540
Cardiac failure 149.02 10.29 366 549524 81727 55660450
Drug reaction with eosinophilia and systemic symptoms 146.83 10.29 56 549834 30248 55711929
Bradycardia 146.68 10.29 272 549618 67232 55674945
Treatment failure 142.90 10.29 2399 547491 167993 55574184
Cardio-respiratory arrest 132.01 10.29 210 549680 55111 55687066
Rhabdomyolysis 131.24 10.29 122 549768 40536 55701641
Hypersensitivity 127.46 10.29 3343 546547 253065 55489112
Rheumatic fever 124.40 10.29 585 549305 28242 55713935
Agitation 122.45 10.29 225 549665 55811 55686366
Red blood cell sedimentation rate abnormal 120.35 10.29 429 549461 18244 55723933
Sopor 118.78 10.29 29 549861 20893 55721284
Vomiting 118.33 10.29 3838 546052 494390 55247787
Respiratory arrest 115.01 10.29 79 549811 30546 55711631
Renal failure 113.64 10.29 624 549266 109876 55632301
Impaired healing 113.47 10.29 1323 548567 85518 55656659
Swollen joint count increased 112.69 10.29 502 549388 23682 55718495
Serotonin syndrome 111.11 10.29 60 549830 26430 55715747
Tachycardia 109.36 10.29 597 549293 105279 55636898
Intentional self-injury 108.70 10.29 54 549836 24938 55717239
Hepatic failure 103.98 10.29 104 549786 33382 55708795
Sickle cell anaemia with crisis 102.91 10.29 180 549710 4848 55737329
Metabolic acidosis 101.88 10.29 148 549742 40306 55701871
Multiple organ dysfunction syndrome 101.57 10.29 228 549662 52542 55689635
Respiratory failure 97.09 10.29 538 549352 94524 55647653
Nausea 93.70 10.29 6321 543569 757857 54984320
Sedation complication 93.39 10.29 5 549885 11667 55730510
Thrombocytopenia 93.32 10.29 865 549025 135359 55606818
Arthritis 92.30 10.29 1429 548461 98423 55643754
Drug resistance 91.45 10.29 43 549847 20499 55721678
Dyspnoea 90.58 10.29 4800 545090 587777 55154400
Sleep disorder due to general medical condition, insomnia type 89.54 10.29 727 549163 42611 55699566
Coma 89.05 10.29 292 549598 59363 55682814
Peripheral swelling 88.69 10.29 2958 546932 231768 55510409
Hepatic function abnormal 88.44 10.29 125 549765 34433 55707744
Hypoglycaemia 87.67 10.29 267 549623 55548 55686629
C-reactive protein abnormal 86.34 10.29 636 549254 36173 55706004
Somnolence 86.17 10.29 1102 548788 162311 55579866
Seizure 85.91 10.29 794 549096 124325 55617852
Blister 85.05 10.29 1516 548374 107371 55634806
Osteoarthritis 84.38 10.29 1175 548715 79121 55663056
Folliculitis 83.96 10.29 864 549026 54115 55688062
Muscle injury 83.02 10.29 831 549059 51669 55690508
Cholestasis 81.95 10.29 85 549805 26828 55715349
Pulmonary arterial hypertension 81.50 10.29 83 549807 26420 55715757
Rash 81.19 10.29 5723 544167 487324 55254853
Renal impairment 79.07 10.29 463 549427 80250 55661927
Hyperglycaemia 79.01 10.29 159 549731 38122 55704055
Drug dependence 78.32 10.29 63 549827 22470 55719707
Hepatocellular injury 78.22 10.29 86 549804 26428 55715749
Blood pressure fluctuation 78.02 10.29 667 549223 39693 55702484
Pregnancy 77.05 10.29 570 549320 32463 55709714
Fibromyalgia 76.49 10.29 905 548985 58698 55683479
Drug withdrawal syndrome 76.13 10.29 84 549806 25773 55716404
Cytomegalovirus infection 74.85 10.29 48 549842 19248 55722929
Lower respiratory tract infection 73.60 10.29 1551 548339 113243 55628934
Angioedema 73.50 10.29 187 549703 41266 55700911
Irritable bowel syndrome 73.23 10.29 1005 548885 67453 55674724
Leukopenia 72.15 10.29 402 549488 70538 55671639
Hypoxia 71.01 10.29 278 549612 53619 55688558
Cardiac failure congestive 70.93 10.29 533 549357 87187 55654990
Sinusitis 70.83 10.29 2475 547415 195106 55547071
Syncope 70.70 10.29 695 549195 107504 55634673
Constipation 70.54 10.29 1470 548420 200473 55541704
Orthostatic hypotension 70.15 10.29 136 549754 33063 55709114
Creatinine renal clearance decreased 68.73 10.29 28 549862 14531 55727646
Encephalopathy 68.49 10.29 152 549738 35173 55707004
Hyperkalaemia 67.89 10.29 261 549629 50604 55691573
Intentional product use issue 67.71 10.29 1359 548531 98374 55643803
Myalgia 67.49 10.29 896 548994 131129 55611048
Contusion 67.36 10.29 1687 548203 126743 55615434
No adverse event 66.90 10.29 161 549729 36213 55705964
Condition aggravated 66.68 10.29 4059 545831 340839 55401338
Anaphylactic reaction 66.35 10.29 323 549567 58672 55683505
Palmar-plantar erythrodysaesthesia syndrome 65.89 10.29 65 549825 21000 55721177
Poisoning 64.93 10.29 22 549868 12791 55729386
Blood cholesterol increased 64.14 10.29 1031 548859 71548 55670629
Mydriasis 63.52 10.29 15 549875 11056 55731121
Anaemia 63.47 10.29 2060 547830 265451 55476726
Shock 62.43 10.29 72 549818 21656 55720521
Hyperhidrosis 62.04 10.29 603 549287 93485 55648692
Acute hepatic failure 61.94 10.29 43 549847 16535 55725642
Metastases to bone 61.24 10.29 60 549830 19448 55722729
Respiratory depression 60.20 10.29 23 549867 12412 55729765
Loss of personal independence in daily activities 59.37 10.29 1121 548769 80248 55661929
Ejection fraction decreased 58.92 10.29 64 549826 19777 55722400
Cognitive disorder 58.79 10.29 263 549627 48870 55693307
Product use in unapproved indication 58.78 10.29 994 548896 139828 55602349
Diarrhoea 57.95 10.29 5411 544479 633096 55109081
Anxiety 57.62 10.29 1441 548449 191731 55550446
Blood glucose increased 57.31 10.29 464 549426 74687 55667490
Osteonecrosis of jaw 57.21 10.29 153 549737 33205 55708972
Schizophrenia 56.84 10.29 16 549874 10483 55731694
Neoplasm progression 56.32 10.29 145 549745 31871 55710306
Live birth 55.63 10.29 355 549535 19250 55722927
Altered state of consciousness 55.28 10.29 87 549803 22934 55719243
Hypothermia 54.14 10.29 27 549863 12443 55729734
Drug level increased 53.99 10.29 74 549816 20651 55721526
Torsade de pointes 53.91 10.29 27 549863 12413 55729764
Ascites 53.82 10.29 187 549703 37357 55704820
Myocardial infarction 53.59 10.29 614 549276 92256 55649921
Blood creatine phosphokinase increased 53.59 10.29 121 549769 27831 55714346
Hypokalaemia 53.47 10.29 627 549263 93810 55648367
Sepsis 53.00 10.29 1004 548886 138836 55603341
Weight increased 52.84 10.29 2747 547143 226956 55515221
Joint effusion 52.77 10.29 286 549604 14612 55727565
Posterior reversible encephalopathy syndrome 52.56 10.29 47 549843 15913 55726264
Unresponsive to stimuli 52.55 10.29 148 549742 31577 55710600
Urticaria 52.32 10.29 1047 548843 143629 55598548
Carpal tunnel syndrome 51.77 10.29 329 549561 17815 55724362
Anaphylactic shock 51.41 10.29 83 549807 21657 55720520
Pulmonary embolism 51.16 10.29 737 549153 106387 55635790
Blood alkaline phosphatase increased 50.59 10.29 202 549688 38743 55703434
Hepatotoxicity 50.38 10.29 147 549743 31006 55711171
Gamma-glutamyltransferase increased 50.36 10.29 146 549744 30859 55711318
Neuroleptic malignant syndrome 49.61 10.29 25 549865 11453 55730724
International normalised ratio increased 49.59 10.29 241 549649 43800 55698377
Metastases to liver 49.57 10.29 84 549806 21502 55720675
Tremor 49.46 10.29 858 549032 120231 55621946
Basal cell carcinoma 49.37 10.29 418 549472 24803 55717374
Abortion spontaneous 48.71 10.29 647 549243 43106 55699071
Injection site erythema 47.88 10.29 1041 548849 76407 55665770
Accidental overdose 47.56 10.29 79 549811 20382 55721795
Pleural effusion 47.45 10.29 570 549320 84910 55657267
Aspartate aminotransferase increased 47.31 10.29 547 549343 82055 55660122
Disability assessment scale score increased 47.04 10.29 91 549799 2653 55739524
Respiratory disorder 46.77 10.29 172 549718 33785 55708392
Foot deformity 46.71 10.29 395 549495 23430 55718747
Coagulopathy 46.60 10.29 69 549821 18647 55723530
Osteoporosis 46.58 10.29 741 549149 51311 55690866
Type 2 diabetes mellitus 46.51 10.29 679 549211 46183 55695994
Intentional product misuse 46.51 10.29 303 549587 51201 55690976
Product quality issue 46.22 10.29 157 549733 31579 55710598
Agranulocytosis 46.00 10.29 95 549795 22564 55719613
Grip strength decreased 45.90 10.29 294 549596 15962 55726215
Blood bilirubin increased 45.25 10.29 170 549720 33184 55708993
Respiratory distress 45.21 10.29 158 549732 31509 55710668
Ill-defined disorder 45.19 10.29 930 548960 67613 55674564
Sensitisation 44.91 10.29 82 549808 2286 55739891
Macular degeneration 44.89 10.29 72 549818 18836 55723341
Alanine aminotransferase increased 44.86 10.29 644 549246 93018 55649159
Disseminated intravascular coagulation 44.47 10.29 66 549824 17819 55724358
Suicidal ideation 44.26 10.29 356 549534 57386 55684791
Transplant rejection 43.90 10.29 21 549869 9913 55732264
Red blood cell sedimentation rate increased 43.90 10.29 549 549341 36074 55706103
Mental status changes 43.52 10.29 203 549687 37298 55704879
Blood calcium decreased 43.09 10.29 106 549784 23663 55718514
Injection site pruritus 42.98 10.29 611 549279 41320 55700857
Cerebral haemorrhage 42.70 10.29 140 549750 28466 55713711
Delirium 42.64 10.29 242 549648 42275 55699902
Ejection fraction 42.63 10.29 67 549823 1648 55740529
Status epilepticus 42.61 10.29 51 549839 15090 55727087
Drug ineffective for unapproved indication 42.45 10.29 120 549770 25573 55716604
Joint laxity 41.95 10.29 81 549809 2358 55739819
Akathisia 41.89 10.29 16 549874 8636 55733541
Loss of consciousness 41.76 10.29 784 549106 108565 55633612
Disorientation 41.43 10.29 200 549690 36413 55705764
Heart rate decreased 41.41 10.29 589 549301 39838 55702339
Infective pulmonary exacerbation of cystic fibrosis 41.34 10.29 14 549876 8143 55734034
Cardiogenic shock 40.83 10.29 60 549830 16265 55725912
Neutrophil count decreased 40.61 10.29 302 549588 49520 55692657
Neurotoxicity 40.54 10.29 57 549833 15738 55726439
Ventricular tachycardia 40.46 10.29 64 549826 16837 55725340
Psychotic disorder 40.44 10.29 108 549782 23450 55718727
Wrong technique in product usage process 40.39 10.29 368 549522 57800 55684377
Pancreatitis acute 40.30 10.29 119 549771 25005 55717172
Extrapyramidal disorder 39.96 10.29 37 549853 12319 55729858
Thrombotic microangiopathy 39.93 10.29 21 549869 9390 55732787
Chest discomfort 39.88 10.29 702 549188 98155 55644022
Blood pressure systolic increased 39.86 10.29 590 549300 40246 55701931
Jaundice 39.76 10.29 135 549755 27159 55715018
Cytokine release syndrome 39.59 10.29 29 549861 10846 55731331
Blood pressure diastolic abnormal 39.30 10.29 220 549670 11378 55730799
Diabetic ketoacidosis 38.41 10.29 79 549811 18792 55723385
Plasma cell myeloma 38.37 10.29 282 549608 46364 55695813
Speech disorder 38.37 10.29 212 549678 37281 55704896
Pyrexia 38.28 10.29 3546 546344 415227 55326950
Toxic skin eruption 38.14 10.29 35 549855 11704 55730473
Acute myeloid leukaemia 38.10 10.29 67 549823 16905 55725272
Mania 37.85 10.29 34 549856 11486 55730691
Disturbance in attention 37.84 10.29 176 549714 32364 55709813
Acute generalised exanthematous pustulosis 37.67 10.29 25 549865 9844 55732333
Polycystic ovaries 37.52 10.29 93 549797 3221 55738956
Deep vein thrombosis 37.31 10.29 528 549362 76449 55665728
Arrhythmia 37.21 10.29 196 549694 34887 55707290
Asphyxia 37.09 10.29 6 549884 5783 55736394
Dizziness 36.99 10.29 3167 546723 372973 55369204
Sinus tachycardia 36.95 10.29 105 549785 22339 55719838
Pulmonary hypertension 36.91 10.29 203 549687 35741 55706436
Asthenia 36.89 10.29 2867 547023 340106 55402071
Accidental exposure to product 36.53 10.29 121 549769 24526 55717651
Myelosuppression 36.45 10.29 72 549818 17383 55724794
Unintentional medical device removal 36.26 10.29 6 549884 5688 55736489
Multiple fractures 36.19 10.29 155 549735 7186 55734991
Injection site reaction 35.93 10.29 725 549165 52522 55689655
Product administration error 35.89 10.29 96 549794 20833 55721344
Pulmonary oedema 35.75 10.29 323 549567 50820 55691357
Breast cancer metastatic 35.70 10.29 60 549830 15409 55726768
Polyneuropathy 35.63 10.29 45 549845 13005 55729172
Febrile bone marrow aplasia 35.61 10.29 10 549880 6562 55735615
Blood pressure systolic abnormal 35.52 10.29 189 549701 9588 55732589
Abnormal behaviour 35.51 10.29 92 549798 20180 55721997
Graft versus host disease 35.49 10.29 11 549879 6770 55735407
Caesarean section 35.46 10.29 274 549616 15817 55726360
Pain in jaw 35.41 10.29 237 549653 39799 55702378
Proteinuria 35.39 10.29 74 549816 17496 55724681
Brain oedema 34.96 10.29 47 549843 13224 55728953
Asthma 34.74 10.29 837 549053 111933 55630244
Pain in extremity 34.61 10.29 3364 546526 294067 55448110
Neck deformity 34.29 10.29 67 549823 1968 55740209
Oropharyngeal pain 34.19 10.29 1066 548824 82722 55659455
Parkinsonism 34.05 10.29 26 549864 9520 55732657
Miosis 33.96 10.29 11 549879 6581 55735596
Obstructive airways disorder 33.80 10.29 74 549816 17208 55724969
Tumour lysis syndrome 33.15 10.29 18 549872 7905 55734272
Liver injury 33.13 10.29 584 549306 41264 55700913
Haemoptysis 33.10 10.29 140 549750 26420 55715757
Stevens-Johnson syndrome 33.08 10.29 112 549778 22551 55719626
Bone erosion 33.01 10.29 255 549635 14719 55727458
Haemophagocytic lymphohistiocytosis 32.97 10.29 27 549863 9545 55732632
Inflammation 32.91 10.29 896 548994 68175 55674002
Melaena 32.91 10.29 153 549737 28137 55714040
Device dislocation 32.80 10.29 112 549778 22494 55719683
Tachypnoea 32.78 10.29 63 549827 15367 55726810
Device difficult to use 32.75 10.29 34 549856 10727 55731450
Atrial fibrillation 32.53 10.29 812 549078 108085 55634092
Myoclonus 32.36 10.29 62 549828 15141 55727036
Haematotoxicity 32.32 10.29 21 549869 8362 55733815
Injection site swelling 31.99 10.29 601 549289 42977 55699200
Stress cardiomyopathy 31.97 10.29 21 549869 8315 55733862
Metastases to central nervous system 31.95 10.29 43 549847 12093 55730084
Emotional distress 31.72 10.29 166 549724 29597 55712580
Dystonia 31.71 10.29 45 549845 12376 55729801
Fear 31.55 10.29 61 549829 14847 55727330
Off label use 31.20 10.29 4864 545026 551316 55190861
Inappropriate antidiuretic hormone secretion 31.15 10.29 54 549836 13702 55728475
Bone marrow failure 31.14 10.29 156 549734 28130 55714047
Disability 31.13 10.29 262 549628 15518 55726659
Hallucination 31.13 10.29 318 549572 48831 55693346
Blood pressure diastolic decreased 31.09 10.29 307 549583 19016 55723161
Rash maculo-papular 30.94 10.29 161 549729 28746 55713431
Toxic epidermal necrolysis 30.78 10.29 111 549779 21931 55720246
Ventricular fibrillation 30.70 10.29 37 549853 10915 55731262
Face oedema 30.62 10.29 86 549804 18366 55723811
Adjustment disorder 30.43 10.29 69 549821 2254 55739923
Bronchopulmonary aspergillosis 30.13 10.29 22 549868 8242 55733935
Fluid retention 29.85 10.29 361 549529 53717 55688460
Tardive dyskinesia 29.78 10.29 21 549869 8010 55734167
Aspergillus infection 29.74 10.29 18 549872 7447 55734730
Pancreatitis 29.67 10.29 289 549601 44791 55697386
Breast cancer stage I 29.38 10.29 12 549878 6218 55735959
Ventricular septal defect 29.21 10.29 98 549792 4040 55738137
Withdrawal syndrome 29.21 10.29 88 549802 18374 55723803
Acute respiratory failure 29.18 10.29 180 549710 30814 55711363
Ischaemic stroke 29.07 10.29 77 549813 16765 55725412
Blood creatinine increased 28.77 10.29 581 549309 79610 55662567
Myopathy 28.75 10.29 32 549858 9780 55732397
Metastases to lung 28.40 10.29 44 549846 11674 55730503
Uterine perforation 28.37 10.29 14 549876 6491 55735686
Joint destruction 28.29 10.29 111 549779 4944 55737233
Complication associated with device 28.18 10.29 68 549822 15282 55726895
Insomnia 28.03 10.29 1560 548330 190300 55551877
Haemorrhage 27.98 10.29 385 549505 56012 55686165
Pulmonary fibrosis 27.90 10.29 427 549463 29331 55712846
Psoriasis 27.87 10.29 1139 548751 91553 55650624
Femur fracture 27.84 10.29 539 549351 38756 55703421
Drug ineffective 27.82 10.29 9687 540203 909302 54832875
Circulatory collapse 27.59 10.29 107 549783 20696 55721481
Injection site pain 27.58 10.29 1404 548486 115714 55626463
Bronchospasm 27.53 10.29 71 549819 15598 55726579
Acute graft versus host disease 27.50 10.29 4 549886 4171 55738006
Aggression 27.42 10.29 116 549774 21890 55720287
Enthesopathy 27.36 10.29 153 549737 7910 55734267
Gestational diabetes 27.35 10.29 153 549737 7911 55734266
Cholecystitis chronic 27.26 10.29 33 549857 9715 55732462
Gastroenteritis viral 27.03 10.29 312 549578 20112 55722065
Hypomagnesaemia 26.95 10.29 139 549751 24876 55717301
Maternal exposure before pregnancy 26.94 10.29 135 549755 6688 55735489
Dyspnoea exertional 26.90 10.29 374 549516 54315 55687862
Intestinal stenosis 26.85 10.29 71 549819 2560 55739617
Epilepsy 26.73 10.29 141 549749 25090 55717087
Gastrointestinal haemorrhage 26.73 10.29 552 549338 75399 55666778
Device use error 26.57 10.29 10 549880 5446 55736731
Depression 26.41 10.29 1464 548426 178653 55563524
Localised infection 26.34 10.29 395 549495 27017 55715160
Laryngitis 26.28 10.29 229 549661 13701 55728476
Maternal drugs affecting foetus 26.25 10.29 109 549781 4984 55737193
Substance abuse 26.22 10.29 6 549884 4519 55737658
Decreased appetite 26.20 10.29 1816 548074 217415 55524762
Drug tolerance decreased 26.10 10.29 222 549668 13189 55728988
Skin cancer 26.06 10.29 182 549708 10173 55732004
Pathogen resistance 26.04 10.29 13 549877 5987 55736190
Premature labour 26 10.29 202 549688 11680 55730497
Stomatitis 25.99 10.29 1436 548454 119374 55622803
Anuria 25.88 10.29 47 549843 11713 55730464
Blood pressure decreased 25.87 10.29 413 549477 58637 55683540
Forced expiratory volume decreased 25.42 10.29 7 549883 4653 55737524
Genital haemorrhage 25.37 10.29 18 549872 6844 55735333
Dehydration 25.34 10.29 1280 548610 157545 55584632
Restlessness 25.24 10.29 154 549736 26432 55715745
Joint range of motion decreased 24.96 10.29 367 549523 24998 55717179
Chronic kidney disease 24.66 10.29 277 549613 41779 55700398
Bone pain 24.39 10.29 344 549546 49841 55692336
Rheumatoid nodule 24.37 10.29 237 549653 14620 55727557
Pseudomonas infection 24.24 10.29 38 549852 10033 55732144
Injection site bruising 24.19 10.29 519 549371 38002 55704175
Polyarthritis 24.12 10.29 157 549733 8571 55733606
Erythema multiforme 24.00 10.29 35 549855 9519 55732658
Pemphigoid 23.99 10.29 16 549874 6284 55735893
Hypomania 23.84 10.29 9 549881 4893 55737284
Temperature regulation disorder 23.84 10.29 7 549883 4461 55737716
Platelet count decreased 23.81 10.29 825 549065 105558 55636619
Synovial cyst 23.81 10.29 163 549727 9051 55733126
Irritability 23.80 10.29 180 549710 29408 55712769
Atrioventricular block complete 23.58 10.29 23 549867 7471 55734706
Palpitations 23.47 10.29 768 549122 98904 55643273
Disease recurrence 23.29 10.29 137 549753 23723 55718454
Cerebral infarction 23.16 10.29 127 549763 22378 55719799
Nodule 23.13 10.29 281 549609 18338 55723839
Coronary artery disease 23.08 10.29 191 549699 30605 55711572
Infection 23.05 10.29 2263 547627 197943 55544234
Haematoma 22.91 10.29 201 549689 31818 55710359
Wheelchair user 22.90 10.29 110 549780 5356 55736821
Body temperature decreased 22.80 10.29 274 549616 17834 55724343
Hepatic cytolysis 22.76 10.29 45 549845 10861 55731316
Cardiomyopathy 22.62 10.29 82 549808 16176 55726001
Eosinophilia 22.52 10.29 110 549780 19967 55722210
Joint stiffness 22.47 10.29 478 549412 34947 55707230
Product complaint 22.47 10.29 51 549839 11709 55730468
Carotid artery thrombosis 22.34 10.29 60 549830 2184 55739993
Joint dislocation 22.25 10.29 244 549646 15529 55726648
Pharyngitis streptococcal 22.20 10.29 164 549726 9334 55732843
Incorrect route of product administration 22.15 10.29 120 549770 21209 55720968
Mucosal inflammation 22.05 10.29 290 549600 42520 55699657
Leukocytosis 21.97 10.29 139 549751 23652 55718525
Pulseless electrical activity 21.59 10.29 22 549868 7002 55735175
Neck mass 21.55 10.29 78 549812 3342 55738835
Skin papilloma 21.53 10.29 94 549796 4395 55737782
Haemorrhage intracranial 21.50 10.29 59 549831 12696 55729481
Juvenile idiopathic arthritis 21.43 10.29 98 549792 4675 55737502
Tenosynovitis stenosans 21.27 10.29 65 549825 2549 55739628
Bradyphrenia 21.20 10.29 20 549870 6600 55735577
Tenderness 21.18 10.29 295 549595 19860 55722317
Tuberculosis 21.17 10.29 182 549708 10847 55731330
Septic shock 21.15 10.29 443 549447 60392 55681785
Neurologic neglect syndrome 21.11 10.29 58 549832 2140 55740037
Injection site rash 21.09 10.29 256 549634 16702 55725475
Transplant dysfunction 21.02 10.29 10 549880 4736 55737441
Nightmare 20.77 10.29 89 549801 16737 55725440
Hypertransaminasaemia 20.73 10.29 10 549880 4697 55737480
Ketoacidosis 20.64 10.29 7 549883 4068 55738109
Dysphagia 20.60 10.29 626 549264 81321 55660856
Limb deformity 20.58 10.29 84 549806 3811 55738366
Cyanosis 20.53 10.29 82 549808 15728 55726449
Poor venous access 20.53 10.29 197 549693 12109 55730068
Vision blurred 20.51 10.29 635 549255 82308 55659869
Acidosis 20.50 10.29 45 549845 10456 55731721
Drug use disorder 20.44 10.29 10 549880 4659 55737518
Red blood cell count decreased 20.38 10.29 485 549405 36132 55706045
Foetal exposure during pregnancy 20.38 10.29 453 549437 33370 55708807
Paradoxical drug reaction 20.35 10.29 6 549884 3814 55738363
Spinal stenosis 20.33 10.29 218 549672 13796 55728381
Cardiotoxicity 20.24 10.29 27 549863 7623 55734554
Latent tuberculosis 20.16 10.29 62 549828 2440 55739737
Blood pressure diastolic increased 20.12 10.29 148 549742 8413 55733764
Renal injury 20.02 10.29 35 549855 8852 55733325
Hypocalcaemia 19.94 10.29 182 549708 28578 55713599
Acute myocardial infarction 19.93 10.29 195 549695 30198 55711979
Multiple-drug resistance 19.83 10.29 7 549883 3967 55738210
Smear cervix abnormal 19.75 10.29 66 549824 2715 55739462
Catatonia 19.75 10.29 7 549883 3957 55738220
C-reactive protein increased 19.71 10.29 949 548941 77735 55664442
Diabetes mellitus 19.54 10.29 380 549510 52355 55689822
Cytomegalovirus viraemia 19.50 10.29 13 549877 5107 55737070
Product substitution issue 19.42 10.29 75 549815 14524 55727653
Interstitial lung disease 19.41 10.29 417 549473 56646 55685531
Small for dates baby 19.34 10.29 77 549813 3453 55738724
Premature rupture of membranes 19.32 10.29 95 549795 4670 55737507
Nephrectomy 19.31 10.29 39 549851 1174 55741003
Glycosylated haemoglobin increased 19.30 10.29 51 549839 11114 55731063
Acute respiratory distress syndrome 19.28 10.29 130 549760 21796 55720381
Psychomotor hyperactivity 19.24 10.29 42 549848 9778 55732399
Rash erythematous 19.22 10.29 252 549638 36969 55705208
Exposure to toxic agent 19.19 10.29 6 549884 3672 55738505
Hyperprolactinaemia 19.05 10.29 6 549884 3655 55738522
Schizoaffective disorder 19.02 10.29 3 549887 2946 55739231
Acute coronary syndrome 18.96 10.29 42 549848 9726 55732451
Klebsiella infection 18.92 10.29 29 549861 7727 55734450
Pulmonary alveolar haemorrhage 18.87 10.29 9 549881 4255 55737922
Right aortic arch 18.78 10.29 17 549873 227 55741950
Dyskinesia 18.57 10.29 188 549702 28920 55713257
Hypervolaemia 18.53 10.29 167 549723 26291 55715886
Musculoskeletal pain 18.52 10.29 970 548920 80182 55661995
Vertigo 18.50 10.29 399 549491 54173 55688004
Influenza 18.50 10.29 1122 548768 94139 55648038
Neuropathy peripheral 18.44 10.29 819 549071 102074 55640103
Pre-eclampsia 18.42 10.29 144 549746 8342 55733835
Pregnancy with contraceptive device 18.37 10.29 9 549881 4190 55737987
Developmental hip dysplasia 18.36 10.29 40 549850 1271 55740906
Lethargy 18.36 10.29 373 549517 51068 55691109
Arthritis infective 18.25 10.29 110 549780 5846 55736331
Drug abuser 18.24 10.29 3 549887 2856 55739321
Adverse event 18.17 10.29 687 549203 54689 55687488
Purpura 18.17 10.29 47 549843 10315 55731862
Epstein-Barr virus infection 18.11 10.29 28 549862 7435 55734742
Dysmorphism 17.98 10.29 55 549835 2158 55740019
Blood pressure increased 17.89 10.29 1649 548241 143527 55598650
Pulmonary haemorrhage 17.89 10.29 24 549866 6759 55735418
Chest pain 17.88 10.29 1603 548287 188194 55553983
Dermatitis bullous 17.82 10.29 29 549861 7544 55734633
Cerebrovascular accident 17.82 10.29 790 549100 98480 55643697
Complication of device insertion 17.70 10.29 22 549868 6402 55735775
Device related infection 17.65 10.29 133 549757 21747 55720430
Skin ulcer 17.59 10.29 498 549392 38110 55704067
Chronic graft versus host disease 17.56 10.29 5 549885 3251 55738926
Treatment noncompliance 17.54 10.29 219 549671 32404 55709773
Hyperthermia 17.45 10.29 34 549856 8251 55733926
Vitamin B12 deficiency 17.40 10.29 87 549803 4306 55737871
Bundle branch block left 17.30 10.29 22 549868 6340 55735837
Cytopenia 17.29 10.29 44 549846 9711 55732466
Rotator cuff repair 17.29 10.29 49 549841 1841 55740336
Immune reconstitution inflammatory syndrome 17.18 10.29 18 549872 5656 55736521
Wrong product administered 17.17 10.29 18 549872 5654 55736523
Hallucinations, mixed 17.17 10.29 11 549879 4413 55737764
Surgery 17.09 10.29 427 549463 32059 55710118
Acute pulmonary oedema 17.04 10.29 30 549860 7567 55734610
Dermatitis exfoliative 16.98 10.29 16 549874 5283 55736894
Hyperammonaemia 16.93 10.29 14 549876 4926 55737251
Second primary malignancy 16.81 10.29 29 549861 7373 55734804
Intervertebral disc degeneration 16.79 10.29 213 549677 14041 55728136
Hyperbilirubinaemia 16.76 10.29 48 549842 10187 55731990
Balance disorder 16.76 10.29 595 549295 75925 55666252
Atrial septal defect 16.76 10.29 115 549775 6391 55735786
Toxic encephalopathy 16.71 10.29 20 549870 5918 55736259
Hallucination, visual 16.68 10.29 101 549789 17367 55724810
Breast cancer stage II 16.63 10.29 19 549871 5739 55736438
Malignant melanoma 16.62 10.29 169 549721 10550 55731627
Hepatitis cholestatic 16.61 10.29 23 549867 6391 55735786
Atrioventricular block 16.56 10.29 26 549864 6861 55735316
Body temperature increased 16.54 10.29 235 549655 34007 55708170
Lupus-like syndrome 16.52 10.29 190 549700 12237 55729940
Abortion incomplete 16.50 10.29 5 549885 3122 55739055
Paranoia 16.44 10.29 52 549838 10692 55731485
Labelled drug-drug interaction medication error 16.41 10.29 58 549832 11528 55730649
Myocardial ischaemia 16.27 10.29 62 549828 12054 55730123
Visual acuity reduced 16.24 10.29 127 549763 20599 55721578
Catheter site pain 16.22 10.29 11 549879 4282 55737895
Hepatitis acute 16.16 10.29 36 549854 8321 55733856
Tubulointerstitial nephritis 16.10 10.29 96 549794 16569 55725608
Product administered to patient of inappropriate age 16.06 10.29 4 549886 2844 55739333
Respiratory acidosis 16.06 10.29 22 549868 6141 55736036
Hospitalisation 16.01 10.29 585 549305 74415 55667762
Pulmonary congestion 16.01 10.29 92 549798 16023 55726154
Colitis microscopic 16.00 10.29 33 549857 7842 55734335
Catheter site erythema 15.96 10.29 10 549880 4060 55738117
Loose body in joint 15.94 10.29 37 549853 1228 55740949
Intestinal resection 15.93 10.29 58 549832 2492 55739685
Frequent bowel movements 15.91 10.29 237 549653 16187 55725990
Paralysis 15.81 10.29 41 549849 8991 55733186
Swollen tongue 15.77 10.29 205 549685 30119 55712058
Cardiac failure acute 15.75 10.29 40 549850 8833 55733344
Angina pectoris 15.73 10.29 186 549704 27790 55714387
Placental disorder 15.64 10.29 40 549850 1413 55740764
Synovial fluid analysis 15.59 10.29 48 549842 1890 55740287
Tendonitis 15.58 10.29 256 549634 17841 55724336
Muscle twitching 15.46 10.29 94 549796 16148 55726029
Generalised oedema 15.38 10.29 81 549809 14420 55727757
Colitis 15.27 10.29 302 549588 41509 55700668
Urinary retention 15.27 10.29 188 549702 27886 55714291
Metastases to lymph nodes 15.17 10.29 31 549859 7392 55734785
Peripheral sensory neuropathy 15.13 10.29 28 549862 6928 55735249
Hyperlipidaemia 15.12 10.29 109 549781 18000 55724177
Aspiration 15.12 10.29 46 549844 9575 55732602
Shock haemorrhagic 15.06 10.29 42 549848 8991 55733186
Oliguria 15.02 10.29 38 549852 8402 55733775
Hypernatraemia 14.98 10.29 26 549864 6594 55735583
Graft versus host disease in skin 14.89 10.29 4 549886 2703 55739474
Benign neoplasm of adrenal gland 14.87 10.29 7 549883 26 55742151
Hepatic necrosis 14.86 10.29 18 549872 5298 55736879
Joint noise 14.83 10.29 75 549815 3729 55738448
Dialysis 14.81 10.29 47 549843 9655 55732522
Renal tubular necrosis 14.81 10.29 55 549835 10773 55731404
Abdominal pain 14.70 10.29 2261 547629 256544 55485633
Potentiating drug interaction 14.60 10.29 11 549879 4055 55738122
Diabetes insipidus 14.59 10.29 3 549887 2434 55739743
Subdural haematoma 14.55 10.29 75 549815 13424 55728753
Hepatitis B reactivation 14.48 10.29 3 549887 2421 55739756
Flushing 14.47 10.29 549 549341 69551 55672626
Right ventricular failure 14.46 10.29 97 549793 16282 55725895
Acute chest syndrome 14.43 10.29 25 549865 668 55741509
Sleep disorder due to a general medical condition 14.42 10.29 144 549746 8946 55733231
Muscle spasticity 14.41 10.29 125 549765 19835 55722342
Breast feeding 14.34 10.29 28 549862 822 55741355
Prescribed underdose 14.33 10.29 282 549608 20335 55721842
Polyuria 14.22 10.29 33 549857 7518 55734659
Congenital arterial malformation 14.20 10.29 17 549873 320 55741857
Breast cancer female 14.19 10.29 67 549823 12271 55729906
Myocarditis 14.17 10.29 42 549848 8816 55733361
Tenosynovitis 14.17 10.29 185 549705 12276 55729901
Drug-induced liver injury 14.12 10.29 244 549646 34218 55707959
Injection site haematoma 14.08 10.29 107 549783 6145 55736032
Ear infection 14.07 10.29 403 549487 30892 55711285
Transaminases increased 14.05 10.29 197 549693 28573 55713604
Maternal exposure timing unspecified 14.05 10.29 96 549794 5327 55736850
Activated partial thromboplastin time prolonged 14.04 10.29 27 549863 6585 55735592
Colorectal cancer 14.04 10.29 8 549882 3421 55738756
Postoperative wound infection 14.04 10.29 146 549744 9167 55733010
Pericardial effusion 14.03 10.29 184 549706 26991 55715186
Herpes zoster 14.02 10.29 890 549000 74999 55667178
Hypoglycaemic coma 14.00 10.29 3 549887 2364 55739813
Polyhydramnios 13.98 10.29 49 549841 2066 55740111
Oedema peripheral 13.93 10.29 1462 548428 169792 55572385
Therapy partial responder 13.89 10.29 35 549855 7750 55734427
Adenovirus infection 13.89 10.29 8 549882 3400 55738777
Hepatitis fulminant 13.82 10.29 7 549883 3197 55738980
Blood test abnormal 13.79 10.29 188 549702 12596 55729581
Electrocardiogram QRS complex prolonged 13.76 10.29 20 549870 5447 55736730
Foot fracture 13.74 10.29 294 549596 21515 55720662
Foetal anticonvulsant syndrome 13.74 10.29 22 549868 550 55741627
Cystitis haemorrhagic 13.69 10.29 11 549879 3926 55738251
Affective disorder 13.62 10.29 21 549869 5582 55736595
Retinitis 13.57 10.29 79 549811 4145 55738032
Therapeutic reaction time decreased 13.55 10.29 43 549847 1721 55740456
Dislocation of vertebra 13.52 10.29 95 549795 5320 55736857
Purging 13.50 10.29 8 549882 52 55742125
Red blood cell sedimentation rate 13.48 10.29 80 549810 4228 55737949
Muscle rigidity 13.45 10.29 56 549834 10615 55731562
Faecal calprotectin increased 13.44 10.29 57 549833 2631 55739546
Neutropenic colitis 13.40 10.29 5 549885 2738 55739439
Ileus 13.39 10.29 80 549810 13802 55728375
Generalised tonic-clonic seizure 13.38 10.29 189 549701 27377 55714800
Therapeutic response decreased 13.36 10.29 637 549253 52121 55690056
Sinus bradycardia 13.26 10.29 78 549812 13508 55728669
Cerebral haematoma 13.26 10.29 8 549882 3315 55738862
Clostridium difficile colitis 13.24 10.29 118 549772 18620 55723557
Synovial disorder 13.23 10.29 32 549858 1091 55741086
Burning sensation 13.20 10.29 592 549298 48104 55694073
Gastrointestinal toxicity 13.19 10.29 25 549865 6131 55736046
Joint injury 13.14 10.29 336 549554 25318 55716859
Malignant mediastinal neoplasm 13.12 10.29 28 549862 877 55741300
Jaundice cholestatic 13.11 10.29 21 549869 5498 55736679
Wound infection 13.10 10.29 215 549675 14978 55727199
Left ventricular dysfunction 13.03 10.29 60 549830 11063 55731114
Gastrointestinal disorder 12.97 10.29 1274 548616 111428 55630749
Haemodynamic instability 12.96 10.29 40 549850 8289 55733888
Hernia 12.96 10.29 161 549729 10562 55731615
Drug screen positive 12.92 10.29 9 549881 3455 55738722
Peripheral venous disease 12.91 10.29 153 549737 9926 55732251
Squamous cell carcinoma 12.89 10.29 129 549761 8019 55734158
Cartilage injury 12.79 10.29 43 549847 1775 55740402
Skin toxicity 12.78 10.29 13 549877 4140 55738037
Device deployment issue 12.76 10.29 10 549880 3614 55738563
Fracture delayed union 12.63 10.29 51 549839 2302 55739875
Body height below normal 12.63 10.29 46 549844 1977 55740200
Systemic inflammatory response syndrome 12.62 10.29 20 549870 5258 55736919
Cyst 12.62 10.29 185 549705 12593 55729584
Bone lesion 12.59 10.29 21 549869 5409 55736768
Clear cell renal cell carcinoma 12.58 10.29 34 549856 1242 55740935
Bone density abnormal 12.53 10.29 64 549826 3195 55738982
Soft tissue disorder 12.51 10.29 14 549876 4268 55737909
Hallucination, auditory 12.43 10.29 64 549826 11460 55730717
Sexual dysfunction 12.38 10.29 9 549881 3379 55738798
Hyperuricaemia 12.34 10.29 19 549871 5054 55737123
Hyperthyroidism 12.33 10.29 78 549812 13274 55728903
Erythema 12.31 10.29 1334 548556 154605 55587572
Multiple sclerosis relapse 12.30 10.29 339 549551 44564 55697613
Metabolic surgery 12.24 10.29 32 549858 1146 55741031
Blood iron increased 12.21 10.29 36 549854 1384 55740793
Haemodialysis 12.17 10.29 43 549847 8548 55733629
Pulmonary toxicity 12.17 10.29 38 549852 7845 55734332
Weight decreased 12.16 10.29 2594 547296 238120 55504057
Granulocytopenia 12.08 10.29 21 549869 5323 55736854
Intracranial pressure increased 12.07 10.29 16 549874 4529 55737648
Kidney transplant rejection 12.06 10.29 14 549876 4199 55737978
Osteonecrosis 12.05 10.29 157 549733 23058 55719119
Persecutory delusion 12.04 10.29 5 549885 2565 55739612
Haematemesis 11.98 10.29 203 549687 28555 55713622
Hypophagia 11.97 10.29 204 549686 28672 55713505
Lung transplant 11.89 10.29 7 549883 2940 55739237
Copper deficiency 11.86 10.29 8 549882 67 55742110
Mobility decreased 11.83 10.29 1122 548768 97869 55644308
Complication of device removal 11.81 10.29 16 549874 4488 55737689
Tonsillar inflammation 11.80 10.29 9 549881 93 55742084
Progressive multifocal leukoencephalopathy 11.71 10.29 69 549821 11944 55730233
Hepatitis C 11.70 10.29 23 549867 5563 55736614
Scleritis 11.66 10.29 69 549821 3642 55738535
Stress 11.65 10.29 695 549195 58215 55683962
Immunodeficiency 11.57 10.29 222 549668 15935 55726242
Coronary arterial stent insertion 11.57 10.29 6 549884 2704 55739473
Mouth ulceration 11.53 10.29 375 549515 29265 55712912
Ankylosing spondylitis 11.53 10.29 148 549742 9782 55732395
Pulmonary tuberculosis 11.46 10.29 79 549811 4397 55737780
Blood urea increased 11.45 10.29 169 549721 24304 55717873
Immunosuppressant drug level increased 11.42 10.29 9 549881 3244 55738933
Lip swelling 11.42 10.29 184 549706 26088 55716089
Post procedural infection 11.35 10.29 128 549762 8204 55733973
Bundle branch block right 11.34 10.29 18 549872 4729 55737448
Discoloured vomit 11.30 10.29 24 549866 749 55741428
Polydipsia 11.30 10.29 9 549881 3226 55738951
Inadequate analgesia 11.27 10.29 6 549884 2665 55739512
Neoplasm recurrence 11.21 10.29 5 549885 2459 55739718
Immunosuppression 11.14 10.29 123 549767 7841 55734336
Enterocolitis 11.14 10.29 34 549856 7070 55735107
Crying 11.13 10.29 145 549745 21295 55720882
Ingrown hair 11.09 10.29 19 549871 503 55741674
Panic attack 11.09 10.29 137 549753 20310 55721867
Lymphoedema 11.07 10.29 59 549831 10471 55731706
Liver transplant 11.05 10.29 4 549886 2232 55739945
Catheter management 11.00 10.29 7 549883 2819 55739358
Hepatic encephalopathy 10.99 10.29 56 549834 10054 55732123
Antibody test positive 10.98 10.29 50 549840 2381 55739796
Liver function test abnormal 10.96 10.29 351 549539 45320 55696857
Dactylitis 10.96 10.29 45 549845 2047 55740130
Talipes 10.94 10.29 35 549855 1407 55740770
Facet joint syndrome 10.94 10.29 107 549783 6610 55735567
Exostosis 10.94 10.29 206 549684 14737 55727440
Rebound effect 10.93 10.29 13 549877 3857 55738320
Myringitis 10.92 10.29 3 549887 0 55742177
Vasa praevia 10.92 10.29 3 549887 0 55742177
Red blood cell count 10.92 10.29 3 549887 0 55742177
Alcoholic seizure 10.92 10.29 3 549887 0 55742177
Thrombosis in device 10.89 10.29 7 549883 2803 55739374
Arnold-Chiari malformation 10.84 10.29 21 549869 613 55741564
Skin plaque 10.81 10.29 34 549856 7004 55735173
Hypoalbuminaemia 10.80 10.29 60 549830 10539 55731638
Mycobacterium tuberculosis complex test positive 10.79 10.29 43 549847 1929 55740248
Eye infection 10.79 10.29 150 549740 10094 55732083
Haemorrhage in pregnancy 10.76 10.29 40 549850 1736 55740441
Hypercapnia 10.66 10.29 21 549869 5075 55737102
Injection site warmth 10.65 10.29 197 549693 14046 55728131
Subarachnoid haemorrhage 10.63 10.29 66 549824 11281 55730896
Prothrombin time prolonged 10.54 10.29 49 549841 9011 55733166
Carcinoma in situ of skin 10.44 10.29 12 549878 216 55741961
Blood bicarbonate decreased 10.42 10.29 7 549883 2739 55739438
Knee operation 10.42 10.29 88 549802 5217 55736960
Lip dry 10.41 10.29 143 549747 9597 55732580
Feeling abnormal 10.40 10.29 1144 548746 132458 55609719
Bacteraemia 10.37 10.29 100 549790 15531 55726646
Rectal haemorrhage 10.36 10.29 317 549573 41150 55701027
Mixed liver injury 10.36 10.29 14 549876 3930 55738247
Hyperpyrexia 10.32 10.29 10 549880 3258 55738919
Anaemia vitamin B12 deficiency 10.31 10.29 15 549875 344 55741833
Rectal abscess 10.31 10.29 29 549861 1085 55741092
Exomphalos 10.30 10.29 19 549871 534 55741643

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 415.08 10.53 36 198065 87722 31411521
Rheumatoid arthritis 369.11 10.53 879 197222 46930 31452313
Toxicity to various agents 356.90 10.53 365 197736 181122 31318121
Completed suicide 316.10 10.53 90 198011 91424 31407819
Foetal exposure during pregnancy 238.71 10.53 677 197424 40199 31459044
Drug interaction 236.04 10.53 604 197497 207939 31291304
Arthralgia 231.92 10.53 1680 196421 149744 31349499
Psoriatic arthropathy 119.62 10.53 333 197768 19550 31479693
Acute kidney injury 117.87 10.53 1149 196952 278565 31220678
Intentional overdose 112.57 10.53 59 198042 41330 31457913
Dysmorphism 108.29 10.53 114 197987 2958 31496285
Joint swelling 106.63 10.53 634 197467 52797 31446446
Blood pressure fluctuation 95.36 10.53 336 197765 22400 31476843
Sickle cell anaemia with crisis 92.17 10.53 102 197999 2805 31496438
Overdose 91.88 10.53 250 197851 84414 31414829
Coma 86.20 10.53 78 198023 41072 31458171
Fatigue 84.56 10.53 2714 195387 332492 31166751
Pain 83.13 10.53 1633 196468 185126 31314117
Enthesopathy 82.28 10.53 117 197984 4170 31495073
Drug reaction with eosinophilia and systemic symptoms 81.31 10.53 43 198058 29975 31469268
Musculoskeletal stiffness 78.39 10.53 484 197617 40841 31458402
Product use in unapproved indication 75.84 10.53 340 197761 98831 31400412
Suicide attempt 75.20 10.53 73 198028 37175 31462068
Serotonin syndrome 71.50 10.53 15 198086 18758 31480485
Rhabdomyolysis 71.05 10.53 185 197916 63396 31435847
Nasopharyngitis 68.75 10.53 650 197451 62595 31436648
Premature baby 66.52 10.53 256 197845 17810 31481433
Multiple organ dysfunction syndrome 63.54 10.53 216 197885 67987 31431256
Peripheral swelling 63.40 10.53 676 197425 67189 31432054
Speech disorder developmental 62.24 10.53 71 198030 2020 31497223
Blood pressure systolic increased 59.90 10.53 261 197840 19209 31480034
Exposure during pregnancy 58.77 10.53 151 197950 8447 31490796
Drug dependence 58.75 10.53 34 198067 22545 31476698
Febrile neutropenia 57.45 10.53 486 197615 121363 31377880
Tenosynovitis 57.19 10.53 98 198003 4112 31495131
Blood pressure increased 56.25 10.53 752 197349 78881 31420362
Arthritis 54.63 10.53 325 197776 27060 31472183
Bradycardia 54.61 10.53 235 197866 69092 31430151
Respiratory arrest 53.53 10.53 51 198050 26206 31473037
Neonatal respiratory distress syndrome 53.52 10.53 91 198010 3794 31495449
Foetal anticonvulsant syndrome 51.56 10.53 49 198052 1120 31498123
Drug resistance 50.87 10.53 43 198058 23410 31475833
Atrial septal defect 50.85 10.53 125 197976 6802 31492441
Cardiac arrest 50.63 10.53 337 197764 88725 31410518
Weight decreased 50.54 10.53 1333 196768 158619 31340624
Sopor 48.87 10.53 7 198094 11545 31487698
Renal failure 48.69 10.53 514 197587 122816 31376427
Pain in extremity 48.58 10.53 1007 197094 115196 31384047
Hepatic function abnormal 48.33 10.53 117 197984 41105 31458138
Cytomegalovirus infection 48.06 10.53 50 198051 24657 31474586
Arthropathy 47.05 10.53 284 197817 23767 31475476
Hypospadias 46.97 10.53 76 198025 3040 31496203
Synovitis 46.82 10.53 176 197925 12107 31487136
Fall 44.98 10.53 1500 196601 184589 31314654
Haemoglobin decreased 44.69 10.53 969 197132 111706 31387537
Heart rate decreased 44.47 10.53 316 197785 27950 31471293
Small for dates baby 44.38 10.53 81 198020 3574 31495669
Maternal exposure during pregnancy 44.17 10.53 93 198008 4563 31494680
Maternal drugs affecting foetus 43.04 10.53 83 198018 3820 31495423
Autism spectrum disorder 42.26 10.53 60 198041 2135 31497108
Osteoarthritis 41.76 10.53 232 197869 18835 31480408
Vitamin B12 deficiency 41.49 10.53 77 198024 3442 31495801
Intentional product misuse 41.19 10.53 112 197989 37839 31461404
Hypoglycaemia neonatal 40.82 10.53 53 198048 1729 31497514
Cryptorchism 40.77 10.53 56 198045 1931 31497312
Learning disorder 40.49 10.53 41 198060 1015 31498228
Respiratory failure 40.35 10.53 422 197679 101027 31398216
Maternal exposure during breast feeding 40.15 10.53 49 198052 1500 31497743
C-reactive protein abnormal 38.97 10.53 122 197979 7647 31491596
Angioedema 38.95 10.53 96 198005 33522 31465721
Lactic acidosis 38.75 10.53 89 198012 31848 31467395
Suicidal ideation 38.35 10.53 109 197992 36297 31462946
Altered state of consciousness 38.31 10.53 45 198056 21006 31478237
Palmar-plantar erythrodysaesthesia syndrome 37.94 10.53 25 198076 15458 31483785
Basal cell carcinoma 37.06 10.53 217 197884 17962 31481281
Alanine aminotransferase abnormal 36.20 10.53 78 198023 3889 31495354
Depressed level of consciousness 36.10 10.53 122 197979 38479 31460764
Rheumatoid nodule 35.88 10.53 62 198039 2619 31496624
Syndactyly 35.78 10.53 35 198066 830 31498413
Drug intolerance 35.75 10.53 489 197612 51544 31447699
Blood pressure systolic abnormal 35.71 10.53 67 198034 3020 31496223
Ventricular septal defect 35.52 10.53 74 198027 3603 31495640
Blood pressure diastolic abnormal 34.90 10.53 77 198024 3902 31495341
Off label use 34.87 10.53 1795 196306 345479 31153764
Drug withdrawal syndrome 34.20 10.53 40 198061 18710 31480533
Tongue disorder 34.18 10.53 88 198013 4929 31494314
Sedation 34.02 10.53 41 198060 18924 31480319
Hepatic failure 33.65 10.53 99 198002 32603 31466640
Low birth weight baby 33.63 10.53 108 197993 6862 31492381
Pathogen resistance 33.03 10.53 7 198094 8694 31490549
Skin cancer 32.93 10.53 131 197970 9254 31489989
Agitation 32.80 10.53 201 197900 53968 31445275
Cardiac failure 32.78 10.53 361 197740 85592 31413651
Foot deformity 32.74 10.53 77 198024 4072 31495171
Psoriasis 32.47 10.53 440 197661 46279 31452964
Toxic epidermal necrolysis 32.15 10.53 45 198056 19479 31479764
Developmental delay 31.97 10.53 58 198043 2547 31496696
Body temperature decreased 31.89 10.53 152 197949 11618 31487625
Pyrexia 31.73 10.53 1564 196537 302276 31196967
Infusion related reaction 31.15 10.53 447 197654 47608 31451635
Substance abuse 31.08 10.53 4 198097 7154 31492089
Hypoglycaemia 30.87 10.53 189 197912 50757 31448486
Hyperbilirubinaemia neonatal 30.65 10.53 30 198071 712 31498531
Joint laxity 29.99 10.53 23 198078 388 31498855
Acute hepatic failure 29.87 10.53 22 198079 12837 31486406
Blood pressure diastolic decreased 29.87 10.53 114 197987 7899 31491344
Back pain 29.54 10.53 894 197207 108519 31390724
Poisoning 29.47 10.53 14 198087 10377 31488866
Talipes 29.16 10.53 46 198055 1800 31497443
Vitamin B12 decreased 29.05 10.53 35 198066 1057 31498186
Pulmonary fibrosis 29.02 10.53 191 197910 16469 31482774
Hypermobility syndrome 28.16 10.53 21 198080 339 31498904
Delirium 28.15 10.53 148 197953 41273 31457970
Psychotic disorder 27.96 10.53 61 198040 22232 31477011
Intellectual disability 27.30 10.53 36 198065 1193 31498050
Somnolence 27.26 10.53 447 197654 98998 31400245
Jaundice neonatal 27.22 10.53 37 198064 1263 31497980
Asthenia 27.22 10.53 1689 196412 223066 31276177
Rash maculo-papular 27.09 10.53 77 198024 25642 31473601
Joint range of motion decreased 26.69 10.53 97 198004 6564 31492679
Congenital hand malformation 26.54 10.53 25 198076 565 31498678
Immune reconstitution inflammatory syndrome 26.48 10.53 9 198092 8169 31491074
Electrocardiogram QT prolonged 26.23 10.53 135 197966 37852 31461391
Poor venous access 26.19 10.53 70 198031 4010 31495233
Exposure via breast milk 26.19 10.53 44 198057 1816 31497427
Hyperglycaemia 26.11 10.53 128 197973 36348 31462895
Shock 25.97 10.53 65 198036 22580 31476663
Death 25.79 10.53 1923 196178 358646 31140597
Neck pain 25.64 10.53 237 197864 22673 31476570
Cataract 25.50 10.53 244 197857 23563 31475680
Musculoskeletal pain 25.49 10.53 292 197809 29536 31469707
Appendicolith 25.38 10.53 3 198098 5728 31493515
Infective pulmonary exacerbation of cystic fibrosis 25.06 10.53 5 198096 6479 31492764
Plagiocephaly 24.81 10.53 23 198078 509 31498734
Back disorder 24.64 10.53 89 198012 6004 31493239
Hand deformity 24.54 10.53 57 198044 2990 31496253
Proteinuria 24.39 10.53 42 198059 16721 31482522
Nasal disorder 24.38 10.53 41 198060 1694 31497549
Full blood count decreased 24.34 10.53 182 197919 16358 31482885
Tendonitis 24.27 10.53 112 197989 8446 31490797
Haemangioma congenital 24.10 10.53 22 198079 477 31498766
Aspergillus infection 23.96 10.53 22 198079 11506 31487737
Joint effusion 23.79 10.53 73 198028 4526 31494717
Astigmatism 23.44 10.53 31 198070 1030 31498213
Knee arthroplasty 23.38 10.53 92 198009 6466 31492777
Language disorder 23.23 10.53 45 198056 2078 31497165
Localised infection 23.05 10.53 169 197932 15096 31484147
Lower respiratory tract infection 23.05 10.53 274 197827 27963 31471280
Malignant neoplasm progression 23.02 10.53 351 197750 78647 31420596
Venoocclusive liver disease 22.58 10.53 9 198092 7403 31491840
Renal impairment 22.40 10.53 392 197709 85957 31413286
Respiratory depression 22.37 10.53 35 198066 14475 31484768
Dysgraphia 22.35 10.53 45 198056 2138 31497105
Anal fistula 22.08 10.53 73 198028 4710 31494533
Vomiting 21.97 10.53 1160 196941 222813 31276430
Anaphylactic shock 21.92 10.53 34 198067 14111 31485132
Large for dates baby 21.22 10.53 27 198074 863 31498380
Disease progression 21.19 10.53 418 197683 90046 31409197
Congenital oesophageal anomaly 21.07 10.53 11 198090 90 31499153
Grip strength decreased 20.77 10.53 49 198052 2597 31496646
Ear infection 20.75 10.53 110 197991 8771 31490472
Knee deformity 20.62 10.53 22 198079 580 31498663
Stevens-Johnson syndrome 20.60 10.53 49 198052 17323 31481920
Loss of personal independence in daily activities 20.30 10.53 268 197833 28020 31471223
Colorectal cancer 20.26 10.53 3 198098 4826 31494417
Vitamin D deficiency 20.17 10.53 82 198019 5850 31493393
Cardiogenic shock 20.16 10.53 72 198029 22336 31476907
Joint stiffness 20.02 10.53 119 197982 9902 31489341
Finger deformity 20.01 10.53 31 198070 1194 31498049
Blood creatine phosphokinase increased 19.93 10.53 167 197934 41807 31457436
Neurotoxicity 19.85 10.53 45 198056 16181 31483062
Polyarthritis 19.72 10.53 65 198036 4187 31495056
Intentional self-injury 19.70 10.53 33 198068 13282 31485961
Selective eating disorder 19.49 10.53 37 198064 1683 31497560
Metabolic acidosis 19.46 10.53 156 197945 39421 31459822
Neck mass 19.42 10.53 35 198066 1529 31497714
Dyspraxia 19.32 10.53 18 198083 401 31498842
Foetal growth restriction 19.22 10.53 60 198041 3755 31495488
Faecal calprotectin increased 19.14 10.53 39 198062 1869 31497374
Post procedural infection 19.09 10.53 67 198034 4456 31494787
Seizure 19.07 10.53 476 197625 99292 31399951
Ankylosing spondylitis 18.98 10.53 80 198021 5801 31493442
Motor developmental delay 18.95 10.53 22 198079 638 31498605
Gait disturbance 18.75 10.53 625 197476 76870 31422373
Blood test abnormal 18.64 10.53 82 198019 6059 31493184
Cardio-respiratory arrest 18.63 10.53 220 197881 51506 31447737
Hypotonia neonatal 18.48 10.53 31 198070 1278 31497965
Medical device implantation 18.37 10.53 21 198080 599 31498644
Wound 18.32 10.53 141 197960 12787 31486456
Hepatocellular injury 18.22 10.53 71 198030 21473 31477770
Incorrect route of product administration 18.15 10.53 28 198073 11645 31487598
Influenza 18.12 10.53 383 197718 43942 31455301
Osteonecrosis of jaw 18.06 10.53 51 198050 17020 31482223
Ventricular fibrillation 18.01 10.53 59 198042 18789 31480454
Otitis media 17.94 10.53 46 198055 2570 31496673
Aggression 17.87 10.53 148 197953 37143 31462100
Urinary tract infection 17.85 10.53 617 197484 76252 31422991
Disseminated intravascular coagulation 17.81 10.53 67 198034 20470 31478773
Blood pressure diastolic increased 17.78 10.53 63 198038 4210 31495033
Kyphosis 17.69 10.53 28 198073 1099 31498144
Hypoaesthesia 17.67 10.53 467 197634 55555 31443688
Throat lesion 17.65 10.53 12 198089 166 31499077
Acute respiratory distress syndrome 17.63 10.53 86 198015 24454 31474789
Caesarean section 17.59 10.53 38 198063 1898 31497345
Nephrolithiasis 17.59 10.53 254 197847 27085 31472158
Hepatic encephalopathy 17.48 10.53 37 198064 13634 31485609
Pancytopenia 17.41 10.53 689 197412 86627 31412616
Spinal disorder 17.36 10.53 59 198042 3861 31495382
Kidney infection 17.26 10.53 68 198033 4782 31494461
Lacrimal disorder 17.10 10.53 15 198086 308 31498935
Brain oedema 17.03 10.53 34 198067 12798 31486445
C-reactive protein increased 16.95 10.53 411 197690 48239 31451004
Diabetic ketoacidosis 16.80 10.53 52 198049 16853 31482390
Dyslexia 16.67 10.53 15 198086 319 31498924
Akinesia 16.65 10.53 38 198063 1970 31497273
Sinusitis 16.63 10.53 322 197779 36374 31462869
Serum ferritin increased 16.57 10.53 76 198025 5716 31493527
Pernicious anaemia 16.52 10.53 9 198092 81 31499162
Pulmonary alveolar haemorrhage 16.48 10.53 11 198090 6755 31492488
No adverse event 16.39 10.53 65 198036 19560 31479683
Acute graft versus host disease 16.39 10.53 9 198092 6144 31493099
Transplant rejection 16.36 10.53 22 198079 9686 31489557
Heart rate 16.33 10.53 4 198097 0 31499243
Strabismus 16.32 10.53 33 198068 1573 31497670
Maternal exposure before pregnancy 16.29 10.53 21 198080 680 31498563
Cholestasis 16.26 10.53 91 198010 24984 31474259
Suspected suicide 16.23 10.53 3 198098 4104 31495139
Drug level increased 16.14 10.53 68 198033 20118 31479125
Tachycardia 16.12 10.53 358 197743 75849 31423394
Intestinal stenosis 16.11 10.53 37 198064 1926 31497317
Akathisia 16.10 10.53 13 198088 7240 31492003
Diaphragmatic disorder 16.08 10.53 27 198074 1114 31498129
Red blood cell sedimentation rate increased 15.97 10.53 98 198003 8248 31490995
Product dose omission issue 15.97 10.53 810 197291 104776 31394467
Urticaria 15.92 10.53 258 197843 57259 31441984
Ear disorder 15.76 10.53 30 198071 1367 31497876
Chronic graft versus host disease 15.75 10.53 4 198097 4388 31494855
Umbilical hernia 15.74 10.53 60 198041 4154 31495089
Bronchopulmonary aspergillosis 15.73 10.53 39 198062 13595 31485648
Thrombocytopenia 15.58 10.53 731 197370 142016 31357227
Heart rate irregular 15.58 10.53 147 197954 14142 31485101
Hypoxia 15.53 10.53 221 197880 50092 31449151
Agranulocytosis 15.53 10.53 74 198027 21173 31478070
Behaviour disorder 15.51 10.53 61 198040 4286 31494957
Pancreatitis acute 15.49 10.53 95 198006 25505 31473738
Bradycardia neonatal 15.46 10.53 24 198077 926 31498317
Progressive multifocal leukoencephalopathy 15.40 10.53 21 198080 9192 31490051
Foetal disorder 15.39 10.53 22 198079 788 31498455
Ventricular tachycardia 15.38 10.53 86 198015 23615 31475628
Cerebral haemorrhage 15.38 10.53 131 197970 32681 31466562
Pneumonia 15.36 10.53 2353 195748 332959 31166284
Inguinal hernia 15.36 10.53 85 198016 6890 31492353
Multiple congenital abnormalities 15.35 10.53 18 198083 528 31498715
Attention deficit hyperactivity disorder 15.25 10.53 41 198060 2357 31496886
Cystitis haemorrhagic 15.19 10.53 7 198094 5282 31493961
Second primary malignancy 15.12 10.53 13 198088 7019 31492224
Scoliosis 15.11 10.53 43 198058 2556 31496687
Congenital bladder anomaly 15.11 10.53 13 198088 260 31498983
Limb reduction defect 15.06 10.53 13 198088 261 31498982
Cleft lip 15.02 10.53 14 198087 312 31498931
Drug withdrawal syndrome neonatal 14.97 10.53 52 198049 3440 31495803
Gamma-glutamyltransferase increased 14.95 10.53 107 197994 27718 31471525
Hydrocele 14.78 10.53 36 198065 1947 31497296
Radiation inflammation 14.77 10.53 18 198083 550 31498693
Weight decrease neonatal 14.70 10.53 14 198087 321 31498922
Neuroleptic malignant syndrome 14.65 10.53 55 198046 16814 31482429
Ascites 14.55 10.53 175 197926 40838 31458405
Blood iron decreased 14.52 10.53 63 198038 4627 31494616
Low set ears 14.48 10.53 16 198085 439 31498804
Blood parathyroid hormone decreased 14.44 10.53 28 198073 1294 31497949
Agitation neonatal 14.43 10.53 25 198076 1058 31498185
Accessory spleen 14.43 10.53 10 198091 143 31499100
Infection 14.40 10.53 638 197463 81293 31417950
Haematocrit decreased 14.38 10.53 266 197835 29795 31469448
Weight increased 14.38 10.53 645 197456 82302 31416941
Arthritis infective 14.36 10.53 46 198055 2919 31496324
Irritability 14.34 10.53 84 198017 22805 31476438
Polyhydramnios 14.28 10.53 12 198089 232 31499011
BK virus infection 14.24 10.53 7 198094 5088 31494155
Cellulitis 14.21 10.53 397 197704 47621 31451622
Drug ineffective for unapproved indication 14.18 10.53 60 198041 17730 31481513
Ankyloglossia congenital 14.16 10.53 13 198088 284 31498959
Intestinal resection 14.13 10.53 31 198070 1565 31497678
Adenovirus infection 14.11 10.53 6 198095 4748 31494495
Congenital foot malformation 14.10 10.53 15 198086 394 31498849
Thrombotic microangiopathy 14.00 10.53 23 198078 9328 31489915
Hyperkalaemia 13.98 10.53 301 197800 64050 31435193
Skin injury 13.92 10.53 33 198068 1754 31497489
Red blood cell sedimentation rate 13.92 10.53 24 198077 1012 31498231
Polydactyly 13.92 10.53 26 198075 1168 31498075
Blood insulin increased 13.88 10.53 14 198087 345 31498898
Hypertriglyceridaemia 13.83 10.53 17 198084 7781 31491462
Cytomegalovirus viraemia 13.78 10.53 13 198088 6712 31492531
Injection site pain 13.75 10.53 298 197803 34336 31464907
Inflammation 13.74 10.53 228 197873 25013 31474230
Arthritis bacterial 13.71 10.53 61 198040 4529 31494714
Increased tendency to bruise 13.70 10.53 52 198049 3593 31495650
Endophthalmitis 13.54 10.53 3 198098 3613 31495630
Hyperammonaemia 13.52 10.53 10 198091 5823 31493420
Obsessive-compulsive disorder 13.47 10.53 7 198094 4930 31494313
Neutropenia 13.35 10.53 729 197372 139635 31359608
Cholelithiasis 13.34 10.53 183 197918 19296 31479947
Rheumatoid lung 13.30 10.53 20 198081 750 31498493
Saliva altered 13.28 10.53 10 198091 164 31499079
Abdominal discomfort 13.27 10.53 419 197682 51148 31448095
Renal aplasia 13.24 10.53 19 198082 683 31498560
Dermatitis acneiform 13.22 10.53 10 198091 5757 31493486
Malignant melanoma 13.21 10.53 88 198013 7619 31491624
Acute generalised exanthematous pustulosis 13.19 10.53 11 198090 6029 31493214
Blood folate decreased 13.15 10.53 19 198082 687 31498556
Potentiating drug interaction 13.12 10.53 6 198095 4547 31494696
Red blood cell count decreased 13.10 10.53 238 197863 26569 31472674
Congenital anomaly 13.05 10.53 27 198074 1308 31497935
Mouth ulceration 13.05 10.53 114 197987 10734 31488509
Mydriasis 13.04 10.53 13 198088 6539 31492704
Septic arthritis staphylococcal 13.03 10.53 16 198085 493 31498750
Gastrointestinal infection 13.01 10.53 62 198039 4738 31494505
Acute graft versus host disease in skin 12.97 10.53 7 198094 4825 31494418
Nocardiosis 12.95 10.53 3 198098 3504 31495739
Pectus excavatum 12.95 10.53 11 198090 216 31499027
Status epilepticus 12.93 10.53 36 198065 12070 31487173
Hypotension 12.91 10.53 1102 196999 203516 31295727
Immunodeficiency 12.89 10.53 61 198040 4648 31494595
Sexual dysfunction 12.87 10.53 11 198090 5957 31493286
Dystonia 12.80 10.53 28 198073 10197 31489046
Arnold-Chiari malformation 12.74 10.53 13 198088 325 31498918
Sacroiliitis 12.74 10.53 27 198074 1331 31497912
Cytokine release syndrome 12.73 10.53 57 198044 16585 31482658
Contusion 12.73 10.53 283 197818 32745 31466498
Microcephaly 12.73 10.53 20 198081 780 31498463
Nephrotic syndrome 12.71 10.53 15 198086 6988 31492255
Gait apraxia 12.70 10.53 4 198097 6 31499237
Oesophageal fibrosis 12.68 10.53 10 198091 176 31499067
Haematochezia 12.67 10.53 337 197764 40127 31459116
Arthrodesis 12.66 10.53 15 198086 445 31498798
Tubulointerstitial nephritis 12.61 10.53 66 198035 18430 31480813
Extrapyramidal disorder 12.59 10.53 35 198066 11743 31487500
Folate deficiency 12.57 10.53 25 198076 1177 31498066
C-reactive protein decreased 12.53 10.53 32 198069 1783 31497460
Cytomegalovirus chorioretinitis 12.53 10.53 3 198098 3425 31495818
Vitamin D decreased 12.49 10.53 45 198056 3032 31496211
Hip fracture 12.47 10.53 114 197987 10872 31488371
Tooth malformation 12.45 10.53 10 198091 181 31499062
Granuloma skin 12.41 10.53 24 198077 1107 31498136
Balance disorder 12.40 10.53 314 197787 37108 31462135
Withdrawal syndrome 12.39 10.53 35 198066 11682 31487561
Stoma site inflammation 12.37 10.53 15 198086 456 31498787
Hepatitis fulminant 12.35 10.53 4 198097 3742 31495501
Vascular insufficiency 12.33 10.53 13 198088 338 31498905
Posterior reversible encephalopathy syndrome 12.27 10.53 25 198076 9342 31489901
Injection site haemorrhage 12.27 10.53 98 198003 8987 31490256
Magnetic resonance imaging spinal abnormal 12.22 10.53 7 198094 70 31499173
Pulmonary arterial hypertension 12.21 10.53 27 198074 9794 31489449
Therapeutic product effect decreased 12.20 10.53 271 197830 31351 31467892
Peripheral coldness 12.17 10.53 76 198025 6436 31492807
Weight fluctuation 12.16 10.53 59 198042 4543 31494700
Cyst 12.14 10.53 55 198046 4115 31495128
Hypokalaemia 12.10 10.53 249 197852 53325 31445918
Hepatotoxicity 12.08 10.53 70 198031 19056 31480187
Respiratory disorder neonatal 12.08 10.53 28 198073 1467 31497776
Chest expansion decreased 12.03 10.53 9 198092 146 31499097
Septic shock 12.01 10.53 318 197783 65840 31433403
Pneumonia aspiration 11.99 10.53 170 197931 38556 31460687
Renal injury 11.93 10.53 31 198070 10634 31488609
Complications of transplanted kidney 11.90 10.53 6 198095 4299 31494944
Psychomotor retardation 11.90 10.53 46 198055 3206 31496037
Oropharyngeal pain 11.90 10.53 269 197832 31214 31468029
Oxygen saturation decreased 11.84 10.53 396 197705 48719 31450524
Product quality issue 11.84 10.53 56 198045 16055 31483188
Therapeutic reaction time decreased 11.84 10.53 21 198080 906 31498337
Frequent bowel movements 11.83 10.53 106 197995 10053 31489190
Ileal stenosis 11.80 10.53 25 198076 1232 31498011
Hypertelorism 11.77 10.53 16 198085 546 31498697
Mobility decreased 11.76 10.53 239 197862 27230 31472013
Blood magnesium decreased 11.75 10.53 69 198032 5717 31493526
Alcohol abuse 11.69 10.53 7 198094 4557 31494686
Unresponsive to stimuli 11.65 10.53 104 197997 25696 31473547
Lordosis 11.63 10.53 11 198090 250 31498993
Maternal exposure timing unspecified 11.62 10.53 13 198088 362 31498881
Pleural fibrosis 11.53 10.53 26 198075 1337 31497906
Acoustic neuroma 11.53 10.53 9 198092 156 31499087
Foetal heart rate deceleration abnormality 11.47 10.53 15 198086 493 31498750
Hepatic cyst 11.43 10.53 37 198064 2361 31496882
Hepatitis E antibody positive 11.41 10.53 11 198090 256 31498987
Juvenile idiopathic arthritis 11.40 10.53 30 198071 1703 31497540
Bronchiolitis 11.39 10.53 42 198059 2862 31496381
Ulna fracture 11.23 10.53 13 198088 376 31498867
Nephropathy toxic 11.22 10.53 35 198066 11318 31487925
Hernia pain 11.21 10.53 11 198090 262 31498981
Foetal distress syndrome 11.21 10.53 22 198079 1026 31498217
Graft versus host disease 11.20 10.53 31 198070 10416 31488827
Hypothyroidism 11.17 10.53 66 198035 17881 31481362
Cardiotoxicity 11.17 10.53 9 198092 5018 31494225
Cardiac flutter 11.08 10.53 30 198071 1732 31497511
Prominent epicanthal folds 11.06 10.53 9 198092 166 31499077
Erythema multiforme 11.04 10.53 21 198080 8050 31491193
Dysstasia 10.96 10.53 112 197989 11006 31488237
Fracture 10.94 10.53 72 198029 6208 31493035
Porphyria acute 10.90 10.53 12 198089 328 31498915
Pharyngeal disorder 10.87 10.53 17 198084 660 31498583
Haemangioma 10.87 10.53 30 198071 1752 31497491
Fistula 10.83 10.53 67 198034 5654 31493589
Benign abdominal neoplasm 10.80 10.53 7 198094 89 31499154
Mania 10.79 10.53 26 198075 9151 31490092
Excessive cerumen production 10.78 10.53 11 198090 275 31498968
Patent ductus arteriosus 10.75 10.53 44 198057 3149 31496094
Cholangitis 10.73 10.53 21 198080 7965 31491278
Anaemia vitamin B12 deficiency 10.64 10.53 12 198089 337 31498906
Abscess intestinal 10.62 10.53 27 198074 1500 31497743
Developmental coordination disorder 10.58 10.53 9 198092 177 31499066
Abdominal hernia 10.55 10.53 38 198063 2560 31496683

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1238.39 10.24 173 566829 226962 70134480
Rheumatoid arthritis 1233.52 10.24 5106 561896 286699 70074743
Toxicity to various agents 1100.32 10.24 867 566135 381305 69980137
Drug abuse 883.12 10.24 80 566922 147176 70214266
Arthropathy 694.50 10.24 2703 564299 147354 70214088
Pemphigus 675.62 10.24 1815 565187 81221 70280221
Joint swelling 674.46 10.24 3884 563118 249327 70112115
Arthralgia 662.85 10.24 6534 560468 496856 69864586
Drug interaction 653.12 10.24 1289 565713 380152 69981290
Systemic lupus erythematosus 648.66 10.24 2040 564962 99862 70261580
Hand deformity 642.91 10.24 1829 565173 84653 70276789
Synovitis 620.18 10.24 2355 564647 126873 70234569
Glossodynia 593.85 10.24 1778 565224 84709 70276733
Infusion related reaction 501.03 10.24 2992 564010 194542 70166900
Anti-cyclic citrullinated peptide antibody positive 487.57 10.24 1449 565553 68736 70292706
Wound 481.62 10.24 1809 565193 96923 70264519
Abdominal discomfort 474.48 10.24 3139 563863 211519 70149923
Pain 470.57 10.24 7341 559661 621475 69739967
Maternal exposure during pregnancy 467.79 10.24 1995 565007 113350 70248092
Pericarditis 465.84 10.24 1614 565388 83091 70278351
Alopecia 438.27 10.24 2902 564100 195588 70165854
Nasopharyngitis 419.92 10.24 3128 563874 219078 70142364
Acute kidney injury 391.40 10.24 2211 564791 472413 69889029
Intentional overdose 378.80 10.24 156 566846 98279 70263163
Discomfort 373.56 10.24 1752 565250 103684 70257758
Swelling 354.35 10.24 2651 564351 185888 70175554
Therapeutic product effect decreased 342.59 10.24 2135 564867 140883 70220559
Musculoskeletal stiffness 315.56 10.24 2143 564859 145617 70215825
Overdose 306.33 10.24 555 566447 169190 70192252
Duodenal ulcer perforation 293.26 10.24 988 566014 50124 70311318
Helicobacter infection 290.84 10.24 1043 565959 54613 70306829
Febrile neutropenia 290.26 10.24 763 566239 203555 70157887
Contraindicated product administered 287.23 10.24 1952 565050 132660 70228782
Rheumatoid factor positive 286.96 10.24 946 566056 47454 70313988
Cardiac arrest 282.72 10.24 529 566473 159305 70202137
Peripheral swelling 264.17 10.24 2973 564029 233590 70127852
Death 263.65 10.24 2706 564296 507355 69854087
Fatigue 257.51 10.24 8503 558499 815816 69545626
Hepatic enzyme increased 257.23 10.24 2139 564863 154851 70206591
Drug intolerance 250.02 10.24 2832 564170 222855 70138587
Sinusitis 241.27 10.24 2236 564766 166959 70194483
Suicide attempt 238.98 10.24 172 566830 79338 70282104
Drug reaction with eosinophilia and systemic symptoms 223.06 10.24 92 566910 57921 70303521
Psoriatic arthropathy 217.50 10.24 1060 565942 63711 70297731
Depressed level of consciousness 211.27 10.24 232 566770 87199 70274243
Rhabdomyolysis 208.16 10.24 276 566726 95484 70265958
Exposure during pregnancy 207.76 10.24 1306 565696 86411 70275031
Impaired healing 204.16 10.24 1151 565851 73223 70288219
Blood pressure fluctuation 201.92 10.24 971 566031 58041 70303401
Bradycardia 196.90 10.24 440 566562 124175 70237267
Arthritis 186.88 10.24 1383 565619 96597 70264845
Multiple organ dysfunction syndrome 181.57 10.24 371 566631 108144 70253298
Respiratory arrest 180.77 10.24 103 566899 53830 70307612
Product use issue 177.17 10.24 2208 564794 177729 70183713
Weight increased 174.90 10.24 2815 564187 239516 70121926
Lower respiratory tract infection 173.81 10.24 1507 565495 110406 70251036
Renal failure 172 10.24 851 566151 188219 70173223
Lactic acidosis 171.39 10.24 160 566842 64864 70296578
C-reactive protein abnormal 168.58 10.24 683 566319 37896 70323546
Serotonin syndrome 168.14 10.24 63 566939 42051 70319391
Hypersensitivity 162.26 10.24 2660 564342 227152 70134290
Sedation 161.33 10.24 86 566916 46645 70314797
Muscle injury 160.71 10.24 672 566330 37822 70323620
Cardiac failure 160.66 10.24 597 566405 142944 70218498
Irritable bowel syndrome 158.57 10.24 815 566187 50035 70311407
Malignant neoplasm progression 158.42 10.24 474 566528 121265 70240177
Respiratory failure 156.63 10.24 754 566248 167981 70193461
Osteoarthritis 153.77 10.24 1068 565934 73079 70288363
Red blood cell sedimentation rate abnormal 152.92 10.24 418 566584 18885 70342557
Hepatic function abnormal 150.83 10.24 193 566809 67803 70293639
Hypotension 149.83 10.24 2302 564700 402079 69959363
Drug resistance 149.36 10.24 59 566943 38131 70323311
Sleep disorder due to general medical condition, insomnia type 149.34 10.24 624 566378 35108 70326334
Folliculitis 148.91 10.24 705 566297 41865 70319577
Cardio-respiratory arrest 148.23 10.24 369 566633 100308 70261134
Sopor 148.16 10.24 34 566968 31233 70330209
Coma 146.13 10.24 323 566679 91521 70269921
Neutropenia 145.30 10.24 1334 565668 255822 70105620
Blister 141.93 10.24 1326 565676 99200 70262242
Sickle cell anaemia with crisis 141.34 10.24 205 566797 5773 70355669
Electrocardiogram QT prolonged 141.01 10.24 284 566718 83233 70278209
Cytomegalovirus infection 140.46 10.24 71 566931 39687 70321755
Hepatic failure 136.91 10.24 155 566847 57470 70303972
Knee arthroplasty 135.62 10.24 589 566413 33712 70327730
Treatment failure 132.62 10.24 1747 565255 142395 70219047
Agitation 129.98 10.24 352 566650 93023 70268419
Contusion 129.36 10.24 1579 565423 126457 70234985
Hip arthroplasty 127.78 10.24 503 566499 27537 70333905
Hyponatraemia 127.10 10.24 754 566248 159333 70202109
Fibromyalgia 125.53 10.24 732 566270 47142 70314300
Pain in extremity 121.69 10.24 3459 563543 324623 70036819
Renal impairment 119.59 10.24 668 566334 143269 70218173
Product use in unapproved indication 119.03 10.24 1072 565930 206406 70155036
Hypoglycaemia 118.78 10.24 373 566629 93991 70267451
Blood pressure systolic increased 113.60 10.24 816 566186 56443 70304999
Drug dependence 113.09 10.24 80 566922 37241 70324201
Disease progression 113.01 10.24 760 566242 155912 70205530
Pregnancy 112.76 10.24 432 566570 23349 70338093
Metabolic acidosis 109.03 10.24 273 566729 74073 70287369
Thrombocytopenia 108.33 10.24 1306 565696 237804 70123638
Blood pressure increased 104.46 10.24 2101 564901 186416 70175026
Ill-defined disorder 102.25 10.24 769 566233 53972 70307470
Respiratory depression 99.37 10.24 37 566965 24794 70336648
Poisoning 98.78 10.24 29 566973 22593 70338849
Tachycardia 98.59 10.24 802 566200 157744 70203698
Heart rate decreased 98.29 10.24 839 566163 61176 70300266
Enthesopathy 94.85 10.24 244 566758 10625 70350817
Infection 92.69 10.24 2273 564729 208512 70152930
Rheumatic fever 92.26 10.24 331 566671 17329 70344113
Angioedema 92.02 10.24 252 566750 66358 70295084
Abortion spontaneous 91.50 10.24 437 566565 26042 70335400
Hyperglycaemia 91.36 10.24 242 566760 64430 70297012
Red blood cell sedimentation rate increased 90.62 10.24 574 566428 38068 70323374
Loss of personal independence in daily activities 90.49 10.24 1058 565944 83852 70277590
Condition aggravated 90.07 10.24 4230 562772 423405 69938037
Cholestasis 88.55 10.24 154 566848 47718 70313724
Shock 88.35 10.24 116 566886 40309 70321133
Intentional self-injury 88.07 10.24 74 566928 31576 70329866
Seizure 88.01 10.24 953 566049 177009 70184433
Hepatocellular injury 86.42 10.24 147 566855 45944 70315498
Injection site erythema 85.12 10.24 925 566077 71999 70289443
Blood pressure diastolic abnormal 84.79 10.24 295 566707 15209 70346233
Disseminated intravascular coagulation 84.67 10.24 86 566916 33512 70327930
Acute hepatic failure 84.26 10.24 59 566943 27613 70333829
Somnolence 82.57 10.24 1219 565783 214387 70147055
Osteoporosis 82.48 10.24 671 566331 48236 70313206
Altered state of consciousness 82.30 10.24 120 566882 39902 70321540
Grip strength decreased 81.95 10.24 294 566708 15391 70346051
Intentional product use issue 81.88 10.24 1383 565619 118759 70242683
Rash 81.79 10.24 4922 562080 505640 69855802
Hyperkalaemia 80.93 10.24 509 566493 106082 70255360
Hypoxia 79.82 10.24 429 566573 92915 70268527
Blood pressure systolic abnormal 78.90 10.24 255 566747 12654 70348788
Sedation complication 78.45 10.24 8 566994 13402 70348040
Leukopenia 78.28 10.24 514 566488 106046 70255396
Mydriasis 77.67 10.24 17 566985 16136 70345306
Intentional product misuse 77.16 10.24 350 566652 79245 70282197
Joint effusion 76.56 10.24 285 566717 15192 70346250
Blood creatine phosphokinase increased 76.49 10.24 243 566759 61020 70300422
Injection site pruritus 76.17 10.24 556 566446 38654 70322788
Blood pressure diastolic decreased 76.09 10.24 407 566595 25373 70336069
Swollen joint count increased 76.07 10.24 262 566740 13438 70348004
Oropharyngeal pain 75.15 10.24 1134 565868 95176 70266266
Device expulsion 72.40 10.24 44 566958 22202 70339240
Cardiac failure congestive 71.19 10.24 715 566287 134742 70226700
Encephalopathy 70.56 10.24 254 566748 61407 70300035
Ascites 70.38 10.24 289 566713 67258 70294184
Pulmonary arterial hypertension 70.05 10.24 96 566906 32759 70328683
Cardiogenic shock 69.73 10.24 114 566888 36193 70325249
Injection site pain 69.54 10.24 1324 565678 116295 70245147
Delirium 69.43 10.24 333 566669 74281 70287161
Drug withdrawal syndrome 69.34 10.24 96 566906 32619 70328823
Inflammation 69.24 10.24 946 566056 77719 70283723
Palmar-plantar erythrodysaesthesia syndrome 69.01 10.24 84 566918 30163 70331279
Post transplant lymphoproliferative disorder 68.11 10.24 4 566998 10541 70350901
Hypothermia 68.05 10.24 40 566962 20554 70340888
Musculoskeletal pain 67.20 10.24 1055 565947 89272 70272170
Injection site reaction 67.06 10.24 651 566351 49201 70312241
Myocardial infarction 66.90 10.24 967 566035 170678 70190764
Vomiting 66.27 10.24 3974 563028 589137 69772305
Anaphylactic shock 66.23 10.24 98 566904 32392 70329050
Disability assessment scale score increased 66.08 10.24 99 566903 2872 70358570
Localised infection 66.03 10.24 473 566529 32685 70328757
Foot deformity 65.74 10.24 333 566669 20322 70341120
Weight decreased 65.66 10.24 3073 563929 307415 70054027
Neuroleptic malignant syndrome 65.05 10.24 67 566935 25940 70335502
Aspergillus infection 64.49 10.24 31 566971 17837 70343605
Ventricular tachycardia 63.94 10.24 121 566881 36302 70325140
Rheumatoid nodule 63.64 10.24 264 566738 14803 70346639
Agranulocytosis 63.03 10.24 143 566859 40155 70321287
Respiratory distress 61.95 10.24 226 566776 54424 70307018
Torsade de pointes 61.56 10.24 34 566968 18082 70343360
Proteinuria 61.45 10.24 87 566915 29287 70332155
Ventricular fibrillation 61.10 10.24 76 566926 27035 70334407
Cerebral haemorrhage 60.90 10.24 223 566779 53641 70307801
Venoocclusive liver disease 60.86 10.24 7 566995 10671 70350771
Carpal tunnel syndrome 60.75 10.24 284 566718 16773 70344669
Sepsis 60.73 10.24 1489 565513 243056 70118386
Gastrointestinal disorder 60.36 10.24 1181 565821 104246 70257196
Body temperature decreased 60.01 10.24 414 566588 28258 70333184
Transplant rejection 59.05 10.24 36 566966 18135 70343307
Stomatitis 58.62 10.24 1393 565609 127118 70234324
Injection site swelling 58.26 10.24 564 566438 42593 70318849
Infective pulmonary exacerbation of cystic fibrosis 58.05 10.24 13 566989 12145 70349297
Joint stiffness 57.37 10.24 479 566523 34697 70326745
Psoriasis 57.15 10.24 1105 565897 97328 70264114
Live birth 57.08 10.24 240 566762 13539 70347903
Ejection fraction decreased 56.86 10.24 99 566903 30663 70330779
Posterior reversible encephalopathy syndrome 56.48 10.24 67 566935 24335 70337107
Pathogen resistance 56.22 10.24 18 566984 13261 70348181
Blood cholesterol increased 56.07 10.24 775 566227 63829 70297613
Status epilepticus 56.07 10.24 68 566934 24458 70336984
Neurotoxicity 56.03 10.24 95 566907 29731 70331711
Suicidal ideation 55.62 10.24 327 566675 69269 70292173
Poor venous access 55.34 10.24 252 566750 14719 70346723
Tenosynovitis 55.24 10.24 240 566762 13736 70347706
Toxic epidermal necrolysis 55.12 10.24 149 566853 39408 70322034
Drug level increased 54.97 10.24 132 566870 36337 70325105
Bronchopulmonary aspergillosis 54.95 10.24 52 566950 20950 70340492
Cytokine release syndrome 52.82 10.24 81 566921 26386 70335056
Rash maculo-papular 52.81 10.24 216 566786 50329 70311113
Caesarean section 52.70 10.24 208 566794 11399 70350043
Immune reconstitution inflammatory syndrome 52.58 10.24 19 566983 12971 70348471
Hypokalaemia 52.55 10.24 735 566267 130453 70230989
Basal cell carcinoma 52.39 10.24 454 566548 33244 70328198
Substance abuse 52.36 10.24 8 566994 9829 70351613
C-reactive protein increased 52.26 10.24 1204 565798 109313 70252129
Joint laxity 52.11 10.24 78 566924 2261 70359181
Polycystic ovaries 51.86 10.24 87 566915 2785 70358657
Thrombotic microangiopathy 51.82 10.24 40 566962 17808 70343634
Sensitisation 51.61 10.24 80 566922 2393 70359049
Aggression 51.27 10.24 206 566796 48240 70313202
Accidental overdose 50.68 10.24 130 566872 34991 70326451
Bone erosion 50.68 10.24 248 566754 14925 70346517
Femur fracture 50.66 10.24 476 566526 35656 70325786
Creatinine renal clearance decreased 50.64 10.24 38 566964 17162 70344280
Unresponsive to stimuli 50.54 10.24 228 566774 51703 70309739
Coagulopathy 50.38 10.24 120 566882 33129 70328313
Brain oedema 50.35 10.24 68 566934 23350 70338092
Injection site bruising 50.34 10.24 495 566507 37537 70323905
Psychotic disorder 50.32 10.24 145 566857 37556 70323886
Gamma-glutamyltransferase increased 50.25 10.24 221 566781 50464 70310978
Syncope 50.04 10.24 978 566024 164731 70196711
Ejection fraction 50.03 10.24 66 566936 1696 70359746
Drug ineffective 49.40 10.24 8384 558618 931368 69430074
Joint range of motion decreased 49.37 10.24 367 566635 25659 70335783
Mucormycosis 48.97 10.24 4 566998 8010 70353432
Pancreatitis acute 48.68 10.24 191 566811 45033 70316409
Miosis 48.59 10.24 26 566976 14075 70347367
Graft versus host disease 48.49 10.24 30 566972 14993 70346449
Extrapyramidal disorder 48.00 10.24 57 566945 20693 70340749
Influenza 47.82 10.24 1219 565783 112481 70248961
Acute respiratory distress syndrome 47.16 10.24 170 566832 41084 70320358
Orthostatic hypotension 46.93 10.24 233 566769 51510 70309932
Synovial cyst 46.65 10.24 165 566837 8577 70352865
Tendonitis 46.64 10.24 320 566682 21802 70339640
Coronary artery disease 46.37 10.24 302 566700 62434 70299008
Acute graft versus host disease 46.10 10.24 10 566992 9552 70351890
Haemoptysis 45.92 10.24 233 566769 51219 70310223
Laryngitis 45.68 10.24 223 566779 13408 70348034
Asphyxia 45.63 10.24 13 566989 10329 70351113
Hyperhidrosis 45.60 10.24 758 566244 130828 70230614
Constipation 45.40 10.24 1606 565396 250832 70110610
Blood pressure diastolic increased 45.37 10.24 208 566794 12183 70349259
Joint destruction 45.01 10.24 109 566893 4569 70356873
Tumour lysis syndrome 44.95 10.24 63 566939 21297 70340145
Osteonecrosis of jaw 44.88 10.24 172 566830 40830 70320612
Anaphylactic reaction 44.88 10.24 383 566619 74591 70286851
Tachypnoea 44.48 10.24 102 566900 28536 70332906
Polyarthritis 44.28 10.24 187 566815 10569 70350873
Acute myeloid leukaemia 44.28 10.24 115 566887 30825 70330617
Hepatotoxicity 44.08 10.24 191 566811 43795 70317647
Diabetic ketoacidosis 43.68 10.24 119 566883 31393 70330049
Gestational diabetes 43.65 10.24 126 566876 5875 70355567
Akathisia 43.35 10.24 22 566980 12271 70349171
Myoclonus 43.30 10.24 91 566911 26264 70335178
Fear 43.18 10.24 62 566940 20749 70340693
Septic shock 43.17 10.24 634 566368 111624 70249818
Disturbance in attention 43.15 10.24 186 566816 42708 70318734
Haemophagocytic lymphohistiocytosis 43.14 10.24 56 566946 19556 70341886
Stevens-Johnson syndrome 43.04 10.24 145 566857 35762 70325680
International normalised ratio increased 42.86 10.24 425 566577 80301 70281141
Pulmonary fibrosis 42.74 10.24 441 566561 33869 70327573
Drug ineffective for unapproved indication 42.61 10.24 161 566841 38377 70323065
Ear infection 42.61 10.24 379 566623 27957 70333485
Drug hypersensitivity 42.48 10.24 1691 565311 260768 70100674
Cerebral infarction 42.35 10.24 188 566814 42821 70318621
Haematotoxicity 41.84 10.24 29 566973 13645 70347797
Melaena 41.80 10.24 271 566731 56084 70305358
Pyrexia 41.76 10.24 4232 562770 602720 69758722
Acute generalised exanthematous pustulosis 41.62 10.24 37 566965 15360 70346082
Mental status changes 41.61 10.24 314 566688 62787 70298655
Juvenile idiopathic arthritis 41.44 10.24 121 566881 5679 70355763
Neoplasm progression 41.40 10.24 203 566799 45025 70316417
BK virus infection 41.39 10.24 7 566995 7982 70353460
Sinus tachycardia 41.30 10.24 136 566866 33777 70327665
Plasma cell myeloma 41.15 10.24 380 566622 72821 70288621
Skin cancer 40.84 10.24 215 566787 13321 70348121
Psychomotor hyperactivity 40.63 10.24 38 566964 15395 70346047
Dystonia 40.60 10.24 59 566943 19647 70341795
Pulmonary alveolar haemorrhage 40.58 10.24 16 566986 10353 70351089
Tongue disorder 40.53 10.24 211 566791 13016 70348426
Injection site rash 40.50 10.24 247 566755 16163 70345279
Irritability 40.15 10.24 163 566839 38062 70323380
Arrhythmia 40.12 10.24 273 566729 55870 70305572
Myalgia 40.11 10.24 1028 565974 166864 70194578
Disability 39.85 10.24 230 566772 14753 70346689
Neck mass 39.70 10.24 97 566905 4089 70357353
Blood alkaline phosphatase increased 39.65 10.24 289 566713 58232 70303210
Inappropriate antidiuretic hormone secretion 39.40 10.24 79 566923 23197 70338245
Aspartate aminotransferase increased 39.07 10.24 747 566255 126231 70235211
Colorectal cancer 38.59 10.24 10 566992 8460 70352982
Joint injury 38.35 10.24 356 566646 26576 70334866
Rhinorrhoea 38.15 10.24 744 566258 65627 70295815
Speech disorder 38.14 10.24 242 566760 50338 70311104
Toxic skin eruption 38.07 10.24 64 566938 20098 70341344
Maternal exposure before pregnancy 37.88 10.24 90 566912 3726 70357716
Mania 37.81 10.24 49 566953 17125 70344317
Pleural effusion 37.76 10.24 792 566210 132072 70229370
Abnormal behaviour 37.74 10.24 146 566856 34563 70326879
Disorientation 37.37 10.24 290 566712 57633 70303809
Febrile bone marrow aplasia 37.26 10.24 25 566977 11966 70349476
Neutrophil count decreased 37.16 10.24 458 566544 83098 70278344
Jaundice 37.14 10.24 241 566761 49867 70311575
Cytomegalovirus viraemia 36.80 10.24 24 566978 11661 70349781
Neck deformity 36.79 10.24 57 566945 1704 70359738
Herpes zoster 36.77 10.24 917 566085 84318 70277124
Blood bilirubin increased 36.75 10.24 304 566698 59597 70301845
Erythema multiforme 36.74 10.24 47 566955 16517 70344925
Red blood cell sedimentation rate 36.60 10.24 104 566898 4806 70356636
Fracture 36.57 10.24 279 566723 19665 70341777
Nodule 36.42 10.24 279 566723 19690 70341752
No adverse event 36.42 10.24 133 566869 32020 70329422
Multiple fractures 36.37 10.24 128 566874 6637 70354805
Intestinal stenosis 36.27 10.24 82 566920 3285 70358157
Hyperthermia 36.26 10.24 48 566954 16623 70344819
Atrial fibrillation 36.13 10.24 1160 565842 183188 70178254
Frequent bowel movements 36.08 10.24 291 566711 20862 70340580
Interstitial lung disease 35.95 10.24 604 566398 104081 70257361
Myelosuppression 35.95 10.24 122 566880 30023 70331419
Blood creatinine increased 35.94 10.24 869 566133 142132 70219310
Ischaemic stroke 35.90 10.24 126 566876 30694 70330748
Schizophrenia 35.74 10.24 49 566953 16719 70344723
Blood glucose increased 35.42 10.24 594 566408 102388 70259054
Adverse event 35.38 10.24 574 566428 48887 70312555
Mobility decreased 35.10 10.24 1075 565927 101924 70259518
Gastroenteritis viral 34.90 10.24 292 566710 21163 70340279
Pulmonary embolism 34.71 10.24 964 566038 154903 70206539
Spinal stenosis 34.56 10.24 218 566784 14435 70347007
Blood test abnormal 34.37 10.24 217 566785 14373 70347069
Appendicolith 34.26 10.24 3 566999 5677 70355765
Fall 33.87 10.24 4050 562952 440046 69921396
Alanine aminotransferase abnormal 33.87 10.24 141 566861 7918 70353524
Hyperbilirubinaemia 33.76 10.24 82 566920 22486 70338956
Tenderness 33.62 10.24 287 566715 20923 70340519
Surgery 33.43 10.24 377 566625 29612 70331830
Hypoaesthesia 33.38 10.24 1526 565476 152213 70209229
Hepatic encephalopathy 33.38 10.24 80 566922 22038 70339404
Klebsiella infection 33.34 10.24 39 566963 14253 70347189
Foot fracture 33.09 10.24 269 566733 19331 70342111
Anuria 33.01 10.24 67 566935 19586 70341856
Leukocytosis 32.97 10.24 184 566818 39484 70321958
Polyneuropathy 32.68 10.24 77 566925 21338 70340104
Hyperammonaemia 32.61 10.24 21 566981 10272 70351170
Burning sensation 32.56 10.24 599 566403 52271 70309171
Pseudomonas infection 32.55 10.24 64 566938 18930 70342512
Intestinal resection 32.48 10.24 78 566924 3252 70358190
Adjustment disorder 32.13 10.24 75 566927 3069 70358373
Metastases to liver 32.05 10.24 103 566899 25775 70335667
Eosinophilia 31.91 10.24 190 566812 40129 70321313
Cognitive disorder 31.90 10.24 322 566680 60634 70300808
Acidosis 31.77 10.24 61 566941 18202 70343240
Withdrawal syndrome 31.63 10.24 98 566904 24806 70336636
Red blood cell count decreased 31.44 10.24 589 566413 51572 70309870
Acute graft versus host disease in skin 31.43 10.24 9 566993 7128 70354314
Vitamin B12 deficiency 31.25 10.24 112 566890 5860 70355582
Wheelchair user 30.97 10.24 102 566900 5112 70356330
Bronchitis 30.96 10.24 1188 565814 116055 70245387
Pneumatosis intestinalis 30.85 10.24 5 566997 5882 70355560
Chronic graft versus host disease 30.83 10.24 8 566994 6762 70354680
Acute myocardial infarction 30.75 10.24 404 566598 72483 70288959
Anaemia 30.63 10.24 2792 564210 400631 69960811
Alanine aminotransferase increased 30.60 10.24 921 566081 146559 70214883
Face oedema 30.41 10.24 104 566898 25535 70335907
Adenovirus infection 30.37 10.24 12 566990 7756 70353686
Latent tuberculosis 30.33 10.24 73 566929 3048 70358394
Mouth ulceration 30.18 10.24 413 566589 33936 70327506
Nocardiosis 30.16 10.24 3 566999 5126 70356316
Hypertransaminasaemia 30.08 10.24 17 566985 8926 70352516
Gastrointestinal haemorrhage 30.04 10.24 852 566150 136556 70224886
Second primary malignancy 30.03 10.24 36 566966 13015 70348427
Faecal calprotectin increased 29.86 10.24 91 566911 4374 70357068
Arthritis infective 29.85 10.24 128 566874 7284 70354158
Epstein-Barr virus infection 29.74 10.24 37 566965 13161 70348281
Wrong technique in product usage process 29.64 10.24 379 566623 68319 70293123
Drug use disorder 29.63 10.24 14 566988 8137 70353305
Pancreatitis 29.60 10.24 339 566663 62329 70299113
Cystitis haemorrhagic 29.38 10.24 16 566986 8577 70352865
Hepatitis B reactivation 29.33 10.24 4 566998 5351 70356091
Neck pain 29.31 10.24 719 566283 65938 70295504
Bradyphrenia 29.25 10.24 22 566980 9924 70351518
Acute coronary syndrome 29.22 10.24 74 566928 20005 70341437
Tardive dyskinesia 29.15 10.24 22 566980 9907 70351535
Pulmonary oedema 29.14 10.24 472 566530 81806 70279636
Skin ulcer 29.14 10.24 544 566458 47601 70313841
Clostridium difficile colitis 29.00 10.24 126 566876 28870 70332572
Pemphigoid 28.87 10.24 42 566960 13980 70347462
Off label use 28.87 10.24 5367 561635 737693 69623749
Exostosis 28.77 10.24 205 566797 14140 70347302
Restlessness 28.56 10.24 208 566794 41920 70319522
Pre-eclampsia 28.47 10.24 115 566887 6370 70355072
Electrocardiogram QRS complex prolonged 28.44 10.24 22 566980 9784 70351658
Potentiating drug interaction 28.21 10.24 15 566987 8149 70353293
Breast cancer stage I 28.19 10.24 7 566995 6095 70355347
Pulmonary hypertension 28.17 10.24 237 566765 46299 70315143
Pulmonary haemorrhage 28.10 10.24 41 566961 13632 70347810
Tooth disorder 28.08 10.24 304 566698 23634 70337808
Skin papilloma 27.96 10.24 101 566901 5305 70356137
Unintentional medical device removal 27.86 10.24 11 566991 7113 70354329
Metastases to bone 27.76 10.24 89 566913 22287 70339155
Shock haemorrhagic 27.71 10.24 65 566937 18041 70343401
Loss of consciousness 27.66 10.24 992 566010 154724 70206718
Post procedural infection 27.58 10.24 159 566843 10194 70351248
Myopathy 27.55 10.24 68 566934 18544 70342898
Premature rupture of membranes 27.54 10.24 81 566921 3817 70357625
Stress cardiomyopathy 27.51 10.24 23 566979 9839 70351603
Myocardial ischaemia 27.48 10.24 100 566902 24100 70337342
Forced expiratory volume decreased 27.47 10.24 12 566990 7302 70354140
Limb deformity 27.41 10.24 75 566927 3390 70358052
Tubulointerstitial nephritis 27.18 10.24 154 566848 32922 70328520
Upper respiratory tract infection 27.17 10.24 828 566174 78446 70282996
Haemorrhage intracranial 27.08 10.24 104 566898 24673 70336769
Hepatocellular carcinoma 27.03 10.24 25 566977 10183 70351259
Exposure to toxic agent 26.93 10.24 8 566994 6186 70355256
Renal injury 26.92 10.24 55 566947 16039 70345403
Joint noise 26.88 10.24 74 566928 3357 70358085
Bone marrow failure 26.86 10.24 256 566746 48754 70312688
Dyspnoea 26.84 10.24 5593 561409 764467 69596975
Neurologic neglect syndrome 26.78 10.24 59 566943 2322 70359120
Urticaria 26.68 10.24 1049 565953 162000 70199442
Respiratory disorder 26.60 10.24 193 566809 38930 70322512
Therapeutic reaction time decreased 26.60 10.24 62 566940 2535 70358907
Catatonia 26.59 10.24 16 566986 8117 70353325
Smear cervix abnormal 26.53 10.24 59 566943 2337 70359105
Subdural haematoma 26.53 10.24 132 566870 29166 70332276
Cyst 26.23 10.24 183 566819 12536 70348906
Premature labour 26.18 10.24 130 566872 7870 70353572
Blood calcium decreased 26.10 10.24 130 566872 28716 70332726
Incorrect route of product administration 25.96 10.24 116 566886 26376 70335066
Cyanosis 25.62 10.24 97 566905 23109 70338333
Immunodeficiency 25.48 10.24 233 566769 17322 70344120
Nephrectomy 25.37 10.24 49 566953 1754 70359688
Bronchospasm 25.34 10.24 95 566907 22697 70338745
Generalised tonic-clonic seizure 25.30 10.24 212 566790 41449 70319993
Carotid artery thrombosis 25.22 10.24 60 566942 2486 70358956
Urinary tract infection 25.21 10.24 2313 564689 246456 70114986
Emotional distress 25.02 10.24 184 566818 37004 70324438
Blood parathyroid hormone decreased 24.97 10.24 140 566862 8884 70352558
Hepatic cytolysis 24.75 10.24 75 566927 19117 70342325
Metastases to lung 24.57 10.24 60 566942 16424 70345018
Gait disturbance 24.56 10.24 1757 565245 183349 70178093
Ulcer 24.43 10.24 314 566688 25440 70336002
Maternal exposure timing unspecified 24.40 10.24 84 566918 4307 70357135
Hepatitis fulminant 24.40 10.24 11 566991 6570 70354872
Joint dislocation 24.29 10.24 199 566803 14332 70347110
Tenosynovitis stenosans 24.22 10.24 56 566946 2277 70359165
Peripheral sensory neuropathy 24.22 10.24 37 566965 12073 70349369
Epilepsy 24.17 10.24 196 566806 38588 70322854
Cardiotoxicity 23.95 10.24 32 566970 11038 70350404
Acute respiratory failure 23.92 10.24 294 566708 53371 70308071
Pharyngitis streptococcal 23.82 10.24 143 566859 9305 70352137
Fear of injection 23.69 10.24 111 566891 6561 70354881
Pneumothorax 23.66 10.24 116 566886 25730 70335712
Device use error 23.59 10.24 12 566990 6684 70354758
Product administration error 23.43 10.24 139 566863 29384 70332058
Transplant dysfunction 23.43 10.24 13 566989 6896 70354546
Oral herpes 23.42 10.24 296 566706 23890 70337552
Rotator cuff repair 23.40 10.24 45 566957 1606 70359836
Paradoxical drug reaction 23.21 10.24 12 566990 6624 70354818
Hypomagnesaemia 23.17 10.24 211 566791 40553 70320889
Hepatitis cholestatic 23.11 10.24 41 566961 12609 70348833
Hyperlactacidaemia 23.08 10.24 6 566996 5066 70356376
Respiratory acidosis 22.98 10.24 29 566973 10252 70351190
Cardiac failure chronic 22.92 10.24 29 566973 10240 70351202
Haemoglobin decreased 22.87 10.24 1921 565081 203238 70158204
Bone disorder 22.83 10.24 227 566775 17263 70344179
Hyperthyroidism 22.82 10.24 83 566919 20008 70341434
Kidney infection 22.79 10.24 247 566755 19208 70342234
Temperature regulation disorder 22.79 10.24 4 566998 4440 70357002
Cytomegalovirus chorioretinitis 22.75 10.24 7 566995 5291 70356151
Therapeutic response decreased 22.63 10.24 620 566382 57833 70303609
Granuloma skin 22.48 10.24 121 566881 7561 70353881
Hyperuricaemia 22.42 10.24 33 566969 10933 70350509
Dermatitis acneiform 22.42 10.24 23 566979 8922 70352520
Enterocolitis 22.41 10.24 44 566958 13022 70348420
Angina pectoris 22.35 10.24 263 566739 48120 70313322
Endophthalmitis 22.35 10.24 11 566991 6244 70355198
Hepatitis acute 22.28 10.24 49 566953 13913 70347529
Hypocalcaemia 22.24 10.24 240 566762 44619 70316823
Headache 22.20 10.24 5099 561903 575306 69786136
Lupus-like syndrome 22.20 10.24 163 566839 11352 70350090
Progressive multifocal leukoencephalopathy 22.08 10.24 79 566923 19135 70342307
Acute lymphocytic leukaemia recurrent 21.94 10.24 6 566996 4898 70356544
Hypoalbuminaemia 21.72 10.24 79 566923 19043 70342399
Sinus bradycardia 21.64 10.24 106 566896 23517 70337925
Increased tendency to bruise 21.62 10.24 142 566860 9533 70351909
Bursitis 21.55 10.24 316 566686 26357 70335085
Hallucination 21.54 10.24 455 566547 75805 70285637
Graft versus host disease in skin 21.52 10.24 9 566993 5621 70355821
Drug abuser 21.43 10.24 10 566992 5854 70355588
Pulseless electrical activity 21.40 10.24 46 566956 13169 70348273
Cardiac failure acute 21.38 10.24 70 566932 17417 70344025
Chronic kidney disease 21.38 10.24 351 566651 60706 70300736
Oesophageal carcinoma 21.37 10.24 26 566976 9340 70352102
Breast cancer stage II 21.33 10.24 8 566994 5338 70356104
Acute chest syndrome 21.32 10.24 32 566970 930 70360512
Persecutory delusion 21.22 10.24 5 566997 4512 70356930
Hepatitis C 21.22 10.24 44 566958 12763 70348679
Sleep disorder due to a general medical condition 21.18 10.24 150 566852 10326 70351116
Product quality issue 21.15 10.24 150 566852 30411 70331031
Haemodynamic instability 21.05 10.24 60 566942 15598 70345844
Compartment syndrome 21.01 10.24 5 566997 4481 70356961
Deep vein thrombosis 20.96 10.24 702 566300 110340 70251102
Transaminases increased 20.80 10.24 258 566744 46760 70314682
Virologic failure 20.79 10.24 3 566999 3847 70357595
Loose body in joint 20.77 10.24 37 566965 1244 70360198
Heparin-induced thrombocytopenia 20.72 10.24 25 566977 9012 70352430
Multiple-drug resistance 20.70 10.24 17 566985 7338 70354104
Synovial fluid analysis 20.67 10.24 46 566956 1823 70359619
Metastases to central nervous system 20.67 10.24 57 566945 14977 70346465
Nephrolithiasis 20.66 10.24 510 566492 46813 70314629
Renal tubular necrosis 20.63 10.24 105 566897 23066 70338376
Toxic encephalopathy 20.62 10.24 32 566970 10374 70351068
Blood lactic acid increased 20.61 10.24 36 566966 11137 70350305
Haemorrhage 20.59 10.24 511 566491 83304 70278138
Purpura 20.59 10.24 74 566928 17901 70343541
Hyperprolactinaemia 20.51 10.24 5 566997 4408 70357034
Anxiety 20.48 10.24 1500 565502 218830 70142612
Circulatory collapse 20.43 10.24 183 566819 35291 70326151
Bradypnoea 20.43 10.24 9 566993 5450 70355992
Malignant melanoma 20.43 10.24 185 566817 13715 70347727
Bladder cancer 20.41 10.24 70 566932 17172 70344270
Sciatica 20.38 10.24 293 566709 24334 70337108
Tremor 20.38 10.24 1026 565976 154598 70206844
Pernicious anaemia 20.26 10.24 24 566978 551 70360891
Pulmonary congestion 20.19 10.24 118 566884 25036 70336406
Nephropathy toxic 20.05 10.24 78 566924 18436 70343006
Haematemesis 20.02 10.24 272 566730 48525 70312917
Paranoia 19.92 10.24 71 566931 17217 70344225
Postoperative wound infection 19.90 10.24 157 566845 11181 70350261
Premature delivery 19.90 10.24 259 566743 21045 70340397
Nephrotic syndrome 19.88 10.24 34 566968 10606 70350836
Fracture delayed union 19.83 10.24 48 566954 2011 70359431
Type 2 diabetes mellitus 19.83 10.24 477 566525 43603 70317839
Ingrown hair 19.41 10.24 25 566977 627 70360815
Cytopenia 19.39 10.24 72 566930 17251 70344191
Kidney transplant rejection 19.39 10.24 31 566971 9930 70351512
Sexual dysfunction 19.36 10.24 15 566987 6666 70354776
Peripheral venous disease 19.31 10.24 149 566853 10538 70350904
Injection site warmth 19.31 10.24 182 566820 13643 70347799
Cataract 19.28 10.24 582 566420 55063 70306379
Retinitis 19.25 10.24 75 566927 4085 70357357
Bacteraemia 19.25 10.24 146 566856 29163 70332279
Ankylosing spondylitis 19.21 10.24 159 566843 11487 70349955
Sudden death 19.01 10.24 95 566907 20969 70340473
Scleritis 19.01 10.24 68 566934 3554 70357888
Hernia 18.98 10.24 192 566810 14668 70346774
Therapeutic product effect incomplete 18.96 10.24 1155 565847 118727 70242715
Hydrocephalus 18.93 10.24 22 566980 8063 70353379
Osteonecrosis 18.80 10.24 146 566856 29014 70332428
Inappropriate schedule of product administration 18.68 10.24 1045 565957 106510 70254932
Coronary arterial stent insertion 18.66 10.24 12 566990 5875 70355567
Vitamin B12 decreased 18.46 10.24 59 566943 2910 70358532
Full blood count decreased 18.40 10.24 281 566721 23637 70337805
Hypertriglyceridaemia 18.40 10.24 42 566960 11769 70349673
Glycosylated haemoglobin increased 18.37 10.24 74 566928 17317 70344125
Intracranial pressure increased 18.34 10.24 19 566983 7337 70354105
Acute pulmonary oedema 18.33 10.24 51 566951 13361 70348081
Panniculitis 18.28 10.24 147 566855 10529 70350913
Dry eye 18.25 10.24 361 566641 31921 70329521
Ileus 18.25 10.24 116 566886 24121 70337321
Cystitis 18.20 10.24 498 566504 46443 70314999
Breast feeding 18.10 10.24 25 566977 672 70360770
Left ventricular dysfunction 17.98 10.24 78 566924 17879 70343563
Visual acuity reduced 17.93 10.24 140 566862 27790 70333652
Affective disorder 17.89 10.24 20 566982 7459 70353983
Aplasia 17.77 10.24 19 566983 7232 70354210
Strongyloidiasis 17.74 10.24 4 566998 3719 70357723
Polyhydramnios 17.72 10.24 38 566964 1468 70359974
Nasal congestion 17.70 10.24 667 566335 65005 70296437
Heart rate irregular 17.63 10.24 335 566667 29408 70332034
Parkinsonism 17.61 10.24 63 566939 15262 70346180
Complications of transplanted kidney 17.61 10.24 13 566989 5921 70355521
Drug-induced liver injury 17.59 10.24 329 566673 55784 70305658
Immune effector cell-associated neurotoxicity syndrome 17.55 10.24 5 566997 3973 70357469
Hallucination, visual 17.49 10.24 150 566852 29187 70332255
Jaundice cholestatic 17.48 10.24 29 566973 9155 70352287
Lip dry 17.45 10.24 136 566866 9649 70351793
Haematoma 17.40 10.24 277 566725 48141 70313301
Accidental exposure to product 17.37 10.24 142 566860 27909 70333533
Uterine perforation 17.36 10.24 13 566989 5878 70355564
Cerebral haematoma 17.35 10.24 20 566982 7358 70354084
Cholangitis 17.25 10.24 42 566960 11507 70349935
Endodontic procedure 17.24 10.24 52 566950 2485 70358957
Knee operation 17.22 10.24 83 566919 4964 70356478
Oliguria 17.22 10.24 62 566940 14989 70346453
Obstructive airways disorder 17.19 10.24 130 566872 25983 70335459
Tuberculosis 17.16 10.24 188 566814 14660 70346782
Eye infection 17.15 10.24 139 566863 9979 70351463
Spinal osteoarthritis 17.13 10.24 193 566809 15155 70346287
Hypercapnia 17.10 10.24 25 566977 8304 70353138
Accidental death 17.08 10.24 5 566997 3903 70357539
Facet joint syndrome 17.02 10.24 95 566907 6018 70355424
Alcohol interaction 16.90 10.24 8 566994 4645 70356797
Polyuria 16.85 10.24 53 566949 13353 70348089
Pneumonia bacterial 16.83 10.24 72 566930 16569 70344873
Epstein-Barr virus associated lymphoproliferative disorder 16.78 10.24 3 566999 3286 70358156
Alcohol abuse 16.76 10.24 10 566992 5097 70356345
Therapy partial responder 16.63 10.24 48 566954 12426 70349016
Rebound effect 16.56 10.24 14 566988 5957 70355485
Device difficult to use 16.56 10.24 39 566963 10810 70350632
Bone density abnormal 16.54 10.24 56 566946 2847 70358595
Intervertebral disc degeneration 16.53 10.24 177 566825 13723 70347719
Purging 16.53 10.24 8 566994 41 70361401
Product dose omission issue 16.50 10.24 1983 565019 215485 70145957
Lacrimal disorder 16.49 10.24 20 566982 471 70360971
Acute graft versus host disease in intestine 16.46 10.24 5 566997 3811 70357631
Malignant mediastinal neoplasm 16.46 10.24 27 566975 848 70360594
Muscle twitching 16.46 10.24 92 566910 19735 70341707
Labelled drug-drug interaction medication error 16.41 10.24 119 566883 24008 70337434
Blood urea increased 16.38 10.24 263 566739 45646 70315796
Cytomegalovirus infection reactivation 16.36 10.24 18 566984 6763 70354679
Hallucination, auditory 16.35 10.24 83 566919 18245 70343197
Dyslipidaemia 16.24 10.24 34 566968 9826 70351616
Anal fistula 16.17 10.24 93 566909 5957 70355485
Lung transplant 16.17 10.24 7 566995 4283 70357159
Tooth infection 16.16 10.24 202 566800 16261 70345181
Blood folate increased 16.14 10.24 20 566982 482 70360960
COVID-19 pneumonia 16.11 10.24 106 566896 21863 70339579
Congestive cardiomyopathy 16.11 10.24 40 566962 10886 70350556
Vitamin D decreased 16.08 10.24 119 566883 8308 70353134
Haematocrit decreased 16.02 10.24 584 566418 56674 70304768
Foot operation 15.95 10.24 79 566923 4778 70356664
Gastric haemorrhage 15.85 10.24 59 566943 14126 70347316
Blood iron decreased 15.83 10.24 169 566833 13092 70348350
Drug screen positive 15.83 10.24 14 566988 5826 70355616
Iodine allergy 15.82 10.24 21 566981 543 70360899
Haematuria 15.78 10.24 387 566615 63186 70298256
Dyskinesia 15.77 10.24 232 566770 40842 70320600
Rheumatoid lung 15.72 10.24 62 566940 3397 70358045
Hyperpyrexia 15.66 10.24 12 566990 5362 70356080
Foetal distress syndrome 15.62 10.24 19 566983 449 70360993
Gingival pain 15.61 10.24 100 566902 6657 70354785
Nausea 15.56 10.24 6359 560643 845729 69515713
Synovial disorder 15.55 10.24 30 566972 1073 70360369
Toothache 15.55 10.24 220 566782 18210 70343232
Palindromic rheumatism 15.51 10.24 18 566984 404 70361038
Benign neoplasm of adrenal gland 15.44 10.24 7 566995 30 70361412
Dactylitis 15.40 10.24 46 566956 2187 70359255
Anhedonia 15.31 10.24 60 566942 14153 70347289
Asthma 15.31 10.24 799 566203 119994 70241448
Haemodialysis 15.29 10.24 79 566923 17287 70344155
Spinal disorder 15.27 10.24 126 566876 9094 70352348
Mean cell volume increased 15.25 10.24 87 566915 5557 70355885
Aspiration 15.23 10.24 81 566921 17594 70343848
Abortion incomplete 15.18 10.24 3 566999 3059 70358383
Product administered to patient of inappropriate age 15.18 10.24 10 566992 4833 70356609
Coronary artery bypass 15.09 10.24 15 566987 5905 70355537
Immunosuppressant drug level increased 15.02 10.24 25 566977 7882 70353560
Illness 14.91 10.24 346 566656 31445 70329997
Dislocation of vertebra 14.90 10.24 78 566924 4822 70356620
Fungaemia 14.86 10.24 7 566995 4075 70357367
Anti-cyclic citrullinated peptide antibody 14.84 10.24 60 566942 3325 70358117
Foetal death 14.82 10.24 93 566909 6146 70355296
Depression 14.78 10.24 1379 565623 197595 70163847
Tonsillar inflammation 14.78 10.24 11 566991 136 70361306
Disturbance in social behaviour 14.76 10.24 7 566995 4060 70357382
Ketoacidosis 14.74 10.24 22 566980 7247 70354195
Decreased appetite 14.73 10.24 2174 564828 302606 70058836
Muscle rigidity 14.70 10.24 88 566914 18562 70342880
Musculoskeletal discomfort 14.70 10.24 212 566790 17620 70343822
Anticholinergic syndrome 14.61 10.24 3 566999 2977 70358465
Antinuclear antibody positive 14.50 10.24 99 566903 6734 70354708
Atrioventricular block complete 14.49 10.24 67 566935 15096 70346346
Type 1 diabetes mellitus 14.45 10.24 17 566985 6197 70355245
Sleep apnoea syndrome 14.42 10.24 353 566649 32360 70329082
Induced labour 14.36 10.24 25 566977 825 70360617
Arthropod bite 14.36 10.24 104 566898 7211 70354231
Polydipsia 14.34 10.24 16 566986 5972 70355470
Hypernatraemia 14.31 10.24 53 566949 12708 70348734
Dermatitis bullous 14.29 10.24 53 566949 12704 70348738
Hepatitis B 14.20 10.24 27 566975 8087 70353355
Angina unstable 14.16 10.24 72 566930 15821 70345621
Pseudomembranous colitis 14.16 10.24 12 566990 5099 70356343
Sinus congestion 14.10 10.24 206 566796 17167 70344275
Adjustment disorder with depressed mood 14.09 10.24 69 566933 4154 70357288
Hepatic necrosis 14.08 10.24 30 566972 8616 70352826
Dysstasia 14.04 10.24 281 566721 24898 70336544
Drug tolerance decreased 14.01 10.24 130 566872 9703 70351739
End stage renal disease 14.01 10.24 44 566958 11089 70350353
Musculoskeletal disorder 14.00 10.24 231 566771 19740 70341702
Human herpesvirus 6 infection 13.97 10.24 11 566991 4848 70356594
Metabolic surgery 13.96 10.24 28 566974 1031 70360411
Disease recurrence 13.89 10.24 214 566788 37389 70324053
Wound infection 13.85 10.24 207 566795 17335 70344107
Mass 13.80 10.24 192 566810 15834 70345608
Bacterial sepsis 13.78 10.24 25 566977 7622 70353820
Metastases to meninges 13.73 10.24 4 566998 3132 70358310
Intervertebral disc protrusion 13.72 10.24 245 566757 21258 70340184
Device related infection 13.72 10.24 178 566824 32007 70329435
Hypoglycaemic coma 13.68 10.24 9 566993 4352 70357090
Lower respiratory tract congestion 13.66 10.24 58 566944 3286 70358156
Acoustic neuroma 13.66 10.24 14 566988 272 70361170
Lipase increased 13.63 10.24 69 566933 15177 70346265
Aphthous ulcer 13.61 10.24 178 566824 14478 70346964
Fluid retention 13.59 10.24 394 566608 62991 70298451
Wrong product administered 13.58 10.24 29 566973 8322 70353120
Human antichimeric antibody positive 13.57 10.24 34 566968 1456 70359986
Metastases to lymph nodes 13.48 10.24 34 566968 9204 70352238
Cellulitis 13.45 10.24 941 566061 97987 70263455
Tooth fracture 13.43 10.24 137 566865 10490 70350952
Sickle cell anaemia 13.40 10.24 21 566981 634 70360808
Hypervolaemia 13.33 10.24 230 566772 39476 70321966
Lymphopenia 13.31 10.24 147 566855 27212 70334230
Oxygen saturation decreased 13.25 10.24 1092 565910 115337 70246105
Viral upper respiratory tract infection 13.23 10.24 115 566887 8427 70353015
Dehydration 13.21 10.24 1594 565408 224548 70136894
Inflammatory bowel disease 13.12 10.24 77 566925 4969 70356473
Platelet count decreased 13.12 10.24 1236 565766 176986 70184456
Pain in jaw 13.12 10.24 251 566751 42418 70319024
Liver transplant 13.11 10.24 9 566993 4257 70357185
Cardiomyopathy 13.11 10.24 141 566861 26232 70335210
Amylase increased 13.09 10.24 40 566962 10168 70351274
Hypoxic-ischaemic encephalopathy 13.07 10.24 24 566978 7284 70354158
Dermatitis exfoliative 13.06 10.24 42 566960 10509 70350933
Metabolic disorder 13.01 10.24 28 566974 8012 70353430
Onychomycosis 12.91 10.24 97 566905 6804 70354638
Nightmare 12.89 10.24 114 566888 22042 70339400
Diabetes mellitus 12.87 10.24 457 566545 71367 70290075
Hypertonia 12.86 10.24 20 566982 6478 70354964
Hypotonia 12.84 10.24 50 566952 11815 70349627
Rhinitis allergic 12.80 10.24 122 566880 9173 70352269
Right ventricular failure 12.79 10.24 115 566887 22159 70339283
Granulocytopenia 12.76 10.24 43 566959 10604 70350838
Osteoporotic fracture 12.75 10.24 62 566940 3722 70357720
Ileal stenosis 12.70 10.24 42 566960 2109 70359333
Fistula 12.68 10.24 138 566864 10743 70350699
Oculogyric crisis 12.65 10.24 3 566999 2695 70358747
Tooth abscess 12.65 10.24 175 566827 14414 70347028
Intestinal obstruction 12.63 10.24 403 566599 38422 70323020
Blood pressure decreased 12.63 10.24 600 566402 90915 70270527
Mucosal inflammation 12.56 10.24 430 566572 67420 70294022
Akinesia 12.55 10.24 54 566948 3077 70358365
Upper respiratory tract inflammation 12.55 10.24 8 566994 3934 70357508
Joint lock 12.54 10.24 52 566950 2915 70358527
Capillary leak syndrome 12.50 10.24 6 566996 3456 70357986
Sensory loss 12.48 10.24 143 566859 11276 70350166
Anal fissure 12.46 10.24 89 566913 6144 70355298
Genital haemorrhage 12.39 10.24 17 566985 5798 70355644
Placental disorder 12.30 10.24 24 566978 866 70360576
Intercepted product preparation error 12.27 10.24 3 566999 2639 70358803
Benign abdominal neoplasm 12.26 10.24 12 566990 220 70361222
Acrochordon 12.24 10.24 25 566977 933 70360509
Pneumonia aspiration 12.18 10.24 392 566610 61897 70299545
Atrioventricular block 12.17 10.24 56 566946 12632 70348810
Myocarditis 12.16 10.24 94 566908 18699 70342743
Ventricular hypokinesia 12.16 10.24 30 566972 8182 70353260
Activated partial thromboplastin time prolonged 12.14 10.24 61 566941 13444 70347998
Delivery 12.12 10.24 19 566983 574 70360868
Ventricular arrhythmia 12.07 10.24 28 566974 7802 70353640
Injection site haemorrhage 12.02 10.24 278 566724 25249 70336193
Osteopenia 12.02 10.24 194 566808 16503 70344939
Antibody test positive 12.02 10.24 46 566956 2485 70358957
Rash erythematous 11.98 10.24 318 566684 51400 70310042
Brain natriuretic peptide increased 11.98 10.24 30 566972 8141 70353301
Renal cancer 11.95 10.24 51 566951 11745 70349697
Psychomotor skills impaired 11.94 10.24 10 566992 4274 70357168
Pneumocystis jirovecii pneumonia 11.87 10.24 169 566833 29913 70331529
Ejection fraction abnormal 11.86 10.24 36 566966 1727 70359715
Cholecystitis chronic 11.83 10.24 37 566965 9339 70352103
Joint warmth 11.82 10.24 33 566969 1509 70359933
Impaired work ability 11.82 10.24 190 566812 16150 70345292
Candida infection 11.80 10.24 199 566803 34274 70327168
Anaemia vitamin B12 deficiency 11.79 10.24 20 566982 646 70360796
Ankle arthroplasty 11.74 10.24 28 566974 1162 70360280
Haemorrhage in pregnancy 11.74 10.24 30 566972 1301 70360141
Product prescribing error 11.71 10.24 230 566772 38722 70322720
Skin toxicity 11.70 10.24 25 566977 7173 70354269
Myringotomy 11.70 10.24 5 566997 18 70361424
Limb injury 11.69 10.24 279 566723 25473 70335969
Hepatic cancer 11.67 10.24 39 566963 9644 70351798
Spinal operation 11.62 10.24 96 566906 6932 70354510
Lymphatic fistula 11.58 10.24 22 566980 778 70360664
Rash morbilliform 11.57 10.24 16 566986 5439 70356003
Cryptococcosis 11.56 10.24 6 566996 3304 70358138
Acute lung injury 11.56 10.24 4 566998 2805 70358637
Vasa praevia 11.51 10.24 3 566999 0 70361442
Red blood cell count 11.51 10.24 3 566999 0 70361442
Injection site urticaria 11.51 10.24 143 566859 11495 70349947
Acute myeloid leukaemia recurrent 11.49 10.24 5 566997 3049 70358393
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.48 10.24 6 566996 3291 70358151
Normal newborn 11.48 10.24 88 566914 6212 70355230
Ileus paralytic 11.47 10.24 34 566968 8727 70352715
Vascular rupture 11.46 10.24 32 566970 1464 70359978
Benign ovarian tumour 11.44 10.24 13 566989 285 70361157
Femoral hernia incarcerated 11.44 10.24 22 566980 785 70360657
Stress 11.34 10.24 658 566344 67308 70294134
Throat lesion 11.34 10.24 13 566989 288 70361154
Radiation inflammation 11.33 10.24 18 566984 550 70360892
Brain injury 11.32 10.24 45 566957 10572 70350870
Blood lactate dehydrogenase increased 11.31 10.24 205 566797 34922 70326520
Hyperlipidaemia 11.30 10.24 129 566873 23734 70337708
Wound infection pseudomonas 11.27 10.24 33 566969 1551 70359891
Malaise 11.27 10.24 3743 563259 429189 69932253
Cervical incompetence 11.25 10.24 17 566985 497 70360945
Metamyelocyte count increased 11.22 10.24 19 566983 613 70360829
Erectile dysfunction 11.22 10.24 63 566939 13499 70347943
Faeces soft 11.21 10.24 94 566908 6816 70354626
Bronchial secretion retention 11.21 10.24 5 566997 3005 70358437
Body height below normal 11.19 10.24 37 566965 1858 70359584
Stillbirth 11.18 10.24 60 566942 3745 70357697
Copper deficiency 11.17 10.24 9 566993 126 70361316
Appendicitis 11.16 10.24 83 566919 16650 70344792
Menstruation delayed 11.15 10.24 28 566974 1201 70360241
Pulmonary pain 11.15 10.24 56 566946 3406 70358036
Vascular purpura 11.14 10.24 4 566998 2742 70358700
Neuropathy peripheral 11.13 10.24 868 566134 126028 70235414
On and off phenomenon 11.13 10.24 48 566954 2738 70358704
Rash pruritic 11.13 10.24 613 566389 62378 70299064
Intestinal ischaemia 11.13 10.24 54 566948 12010 70349432
Diaphragmatic disorder 11.12 10.24 33 566969 1563 70359879
Hypertensive emergency 11.05 10.24 3 566999 2460 70358982
Colitis microscopic 11.04 10.24 36 566966 8969 70352473
Skin laceration 11.03 10.24 278 566724 25600 70335842
Cushingoid 11.01 10.24 109 566893 8279 70353163
Back disorder 10.97 10.24 131 566871 10433 70351009
Skin fissures 10.94 10.24 138 566864 11132 70350310
Cerebellar haemorrhage 10.94 10.24 4 566998 2711 70358731
Dental caries 10.94 10.24 137 566865 11034 70350408
Pleuritic pain 10.91 10.24 114 566888 8783 70352659
Extradural haematoma 10.87 10.24 4 566998 2701 70358741
Abortion threatened 10.87 10.24 15 566987 403 70361039
Immunosuppression 10.85 10.24 140 566862 11352 70350090
Hiatus hernia 10.85 10.24 233 566769 20901 70340541
Gastric cancer 10.84 10.24 36 566966 8919 70352523
Arthritis bacterial 10.82 10.24 107 566895 8126 70353316
Generalised oedema 10.81 10.24 116 566886 21592 70339850
Human anti-human antibody test 10.81 10.24 15 566987 405 70361037
Hypomania 10.81 10.24 20 566982 6052 70355390
Vitamin B complex deficiency 10.80 10.24 18 566984 573 70360869
Tuberculin test positive 10.80 10.24 53 566949 3193 70358249
Retinal haemorrhage 10.77 10.24 29 566973 7681 70353761
Mixed liver injury 10.76 10.24 21 566981 6228 70355214
Mycobacterium tuberculosis complex test positive 10.75 10.24 42 566960 2291 70359151
Umbilical hernia 10.73 10.24 75 566927 5141 70356301
Lower limb fracture 10.67 10.24 191 566811 16581 70344861
Linear IgA disease 10.66 10.24 5 566997 2919 70358523
Walking aid user 10.62 10.24 104 566898 7877 70353565
Vision blurred 10.62 10.24 636 566366 94348 70267094
Accessory spleen 10.59 10.24 10 566992 175 70361267
Paralysis 10.58 10.24 55 566947 12017 70349425
Tendon disorder 10.57 10.24 89 566913 6462 70354980
Hysterectomy 10.57 10.24 79 566923 5533 70355909
Oesophageal fibrosis 10.55 10.24 10 566992 176 70361266
Pancreatic steatosis 10.52 10.24 25 566977 1035 70360407
Pneumomediastinum 10.51 10.24 7 566995 3363 70358079
Gastrooesophageal reflux disease 10.50 10.24 853 566149 89986 70271456
Quadriparesis 10.47 10.24 6 566996 3127 70358315
Systemic inflammatory response syndrome 10.44 10.24 47 566955 10665 70350777
Hypogammaglobulinaemia 10.44 10.24 52 566950 11486 70349956
Intra-abdominal haemorrhage 10.40 10.24 11 566991 4207 70357235
Conduction disorder 10.38 10.24 6 566996 3112 70358330
Skin abrasion 10.38 10.24 147 566855 12170 70349272
Obesity 10.37 10.24 284 566718 26487 70334955
Body temperature fluctuation 10.37 10.24 56 566946 3503 70357939
Placental insufficiency 10.35 10.24 25 566977 1046 70360396
Chronic disease 10.35 10.24 8 566994 105 70361337
Drug level below therapeutic 10.33 10.24 111 566891 8612 70352830
Prostate cancer 10.31 10.24 181 566821 30982 70330460
Stoma site inflammation 10.28 10.24 18 566984 597 70360845

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03BA01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
ATC B03BA51 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
FDA CS M0022794 Vitamin B 12
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
FDA EPC N0000175951 Vitamin B12
CHEBI has role CHEBI:33229 vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pernicious anemia indication 84027009 DOID:13381
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Cobalamin deficiency indication 190634004
Prevention of Vitamin B12 Deficiency indication
Vitamin Deficiency Prevention indication
Homocystinuria off-label use 11282001 DOID:9263
Methylmalonic acidemia off-label use 42393006
Homocystinemia off-label use 52311001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 8940714 Feb. 26, 2024 CYANOCOBALAMIN ADMINISTRATION THROUGH NASAL INFUSION
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 9415007 July 28, 2024 SUPPLEMENT FOR VITAMIN B12 DEFICIENCIES
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 7229636 Aug. 1, 2024 NASAL ADMINISTRATION OF CYANOCOBALAMIN
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 7879349 Aug. 1, 2024 CYANOCOBALAMIN ADMINISTRATION THROUGH NASAL INFUSION
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 8003353 Aug. 1, 2024 NASAL ADMINISTRATION OF CYANOCOBALAMIN

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Methionine synthase Enzyme WOMBAT-PK
Methionine synthase reductase Enzyme WOMBAT-PK
Protein amnionless Unclassified WOMBAT-PK
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial Enzyme WOMBAT-PK
Methylmalonic aciduria type A protein, mitochondrial Enzyme WOMBAT-PK
Transcobalamin-2 Secreted WOMBAT-PK
Transcobalamin-1 Secreted WOMBAT-PK

External reference:

IDSource
4021085 VUID
N0000148543 NUI
D00166 KEGG_DRUG
4017441 VANDF
4017907 VANDF
4021085 VANDF
4021896 VANDF
C0042845 UMLSCUI
CHEBI:17439 CHEBI
CNC PDB_CHEM_ID
CHEMBL2110563 ChEMBL_ID
CHEMBL2375172 ChEMBL_ID
DB00115 DRUGBANK_ID
1369 INN_ID
P6YC3EG204 UNII
54605677 PUBCHEM_CID
11248 RXNORM
213062 MMSL
257021 MMSL
4514 MMSL
5682 MMSL
6832 MMSL
6837 MMSL
8312 MMSL
d00413 MMSL
001043 NDDF
30010009 SNOMEDCT_US
304111003 SNOMEDCT_US
419382002 SNOMEDCT_US
D014805 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9619 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9619 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9620 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9620 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9621 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9621 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 12 ug ORAL unapproved drug other 17 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 12 ug ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 12 ug ORAL Unapproved drug other 12 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 16.80 ug ORAL unapproved drug other 15 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 16.80 ug ORAL unapproved drug other 15 sections
CYANOCOBALAMIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9840 INJECTION 1000 ug INTRAMUSCULAR ANDA 11 sections
CYANOCOBALAMIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9840 INJECTION 1000 ug INTRAMUSCULAR ANDA 11 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0031 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0031 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0032 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0032 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0130 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0130 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 0.01 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 5 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 12 ug ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 12 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 12 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 12 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 50 ug ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 50 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 0.01 mg ORAL unapproved drug other 7 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 12 ug ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 25 ug ORAL UNAPPROVED DRUG OTHER 14 sections