lutein 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4145 127-40-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lutein
  • xanthophyll
A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.
  • Molecular weight: 568.89
  • Formula: C40H56O2
  • CLOGP: 11.23
  • LIPINSKI: 2
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -5.89
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 26.75 18.85 14 2833 14374 50587903
Fall 26.33 18.85 58 2789 334874 50267403

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fall 25.16 18.92 58 2945 416768 64078961
Fatigue 23.38 18.92 82 2921 748648 63747081
Macular degeneration 19.51 18.92 8 2995 5702 64490027

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77182 food coloring

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Tear film insufficiency indication 46152009
Age related macular degeneration indication 267718000 DOID:10871
Meibomian gland dysfunction indication 397549002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4024342 VUID
N0000171226 NUI
4024342 VANDF
C0043328 UMLSCUI
CHEBI:28838 CHEBI
LUT PDB_CHEM_ID
CHEMBL173929 ChEMBL_ID
D014975 MESH_DESCRIPTOR_UI
DB00137 DRUGBANK_ID
X72A60C9MT UNII
5281243 PUBCHEM_CID
11359 RXNORM
117565 MMSL
24043 MMSL
d06848 MMSL
008098 NDDF
009220 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 5 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Ocuvel HUMAN PRESCRIPTION DRUG LABEL 7 69054-210 CAPSULE 10 mg ORAL unapproved drug other 9 sections
Ocuvel HUMAN PRESCRIPTION DRUG LABEL 7 69054-211 CAPSULE 5 mg ORAL unapproved drug other 9 sections
Noon for Kids HUMAN OTC DRUG LABEL 1 82597-010 POWDER 10 mg ORAL unapproved drug other 10 sections