lutein 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4145	127-40-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

lutein
xanthophyll

A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.

Molecular weight: 568.89
Formula: C40H56O2
CLOGP: 11.23
LIPINSKI: 2
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS: -5.89
ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fall	27.31	19.37	60	3087	392274	63093601
Macular degeneration	21.53	19.37	14	3133	24362	63461513

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	122.78	33.05	37	2012	8564	34946318
Blood phosphorus increased	117.93	33.05	35	2014	7686	34947196
Appendicitis	103.03	33.05	37	2012	14770	34940112
Ventricular fibrillation	87.28	33.05	37	2012	22917	34931965
Stress	83.54	33.05	39	2010	30308	34924574
Cardiogenic shock	82.01	33.05	37	2012	26581	34928301
Dry mouth	71.53	33.05	35	2014	30130	34924752
Ascites	65.10	33.05	38	2011	46533	34908349
Myasthenia gravis	62.33	33.05	21	2028	6919	34947963
Blood uric acid increased	59.28	33.05	22	2027	9602	34945280
Abdominal distension	57.13	33.05	38	2011	58454	34896428
Constipation	49.91	33.05	50	1999	136932	34817950
Hyponatraemia	47.46	33.05	39	2010	82652	34872230
Multiple organ dysfunction syndrome	45.80	33.05	37	2012	76529	34878353
Blood cholesterol increased	40.33	33.05	21	2028	20522	34934360
Somnolence	35.78	33.05	38	2011	111078	34843804
Incorrect route of product administration	34.46	33.05	17	2032	14828	34940054
Sepsis	33.83	33.05	45	2004	166516	34788366

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	126.63	21.15	37	4174	8514	79731663
Blood phosphorus increased	111.28	21.15	35	4176	10312	79729865
Appendicitis	97.93	21.15	38	4173	20756	79719421
Ventricular fibrillation	85.36	21.15	39	4172	31887	79708290
Cardiogenic shock	69.57	21.15	37	4174	41877	79698300
Stress	68.47	21.15	46	4165	79566	79660611
Myasthenia gravis	59.79	21.15	22	4189	10377	79729800
Blood uric acid increased	54.44	21.15	22	4189	13338	79726839
Abdominal distension	53.83	21.15	47	4164	119603	79620574
Dry mouth	50.90	21.15	40	4171	87979	79652198
Ascites	49.52	21.15	37	4174	75525	79664652
Hyponatraemia	36.64	21.15	46	4165	177802	79562375
Multiple organ dysfunction syndrome	34.67	21.15	37	4174	120209	79619968
Constipation	30.49	21.15	54	4157	282996	79457181
Incorrect route of product administration	24.88	21.15	18	4193	34911	79705266
Somnolence	23.69	21.15	44	4167	238937	79501240
Sepsis	23.52	21.15	47	4164	269381	79470796

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77182	food coloring

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Tear film insufficiency	indication	46152009
Age related macular degeneration	indication	267718000	DOID:10871
Meibomian gland dysfunction	indication	397549002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4024342	VUID
N0000171226	NUI
4024342	VANDF
C0043328	UMLSCUI
CHEBI:28838	CHEBI
LUT	PDB_CHEM_ID
CHEMBL173929	ChEMBL_ID
D014975	MESH_DESCRIPTOR_UI
DB00137	DRUGBANK_ID
X72A60C9MT	UNII
5281243	PUBCHEM_CID
11359	RXNORM
117565	MMSL
24043	MMSL
d06848	MMSL
008098	NDDF
009220	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	5 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	5 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Ocuvel	HUMAN PRESCRIPTION DRUG LABEL	7	69054-210	CAPSULE	10 mg	ORAL	unapproved drug other	9 sections
Ocuvel	HUMAN PRESCRIPTION DRUG LABEL	7	69054-211	CAPSULE	5 mg	ORAL	unapproved drug other	9 sections
Vista Advanced Carotenoid Formula	HUMAN OTC DRUG LABEL	7	77790-007	CAPSULE	5 mg	ORAL	unapproved drug other	10 sections
Noon for Kids	HUMAN OTC DRUG LABEL	1	82597-010	POWDER	10 mg	ORAL	unapproved drug other	10 sections
Furryden Dental Easy Green	HUMAN OTC DRUG LABEL	2	83332-401	GUM, CHEWING	0.01 g	ORAL	unapproved drug other	11 sections