spaglumic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4050 4910-46-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • spaglumic acid
  • beta-NAAG
  • Molecular weight: 304.26
  • Formula: C11H16N2O8
  • CLOGP: -2.11
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 5
  • TPSA: 170.10
  • ALOGS: -1.97
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01AC05 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Antiallergic agents, excl. corticosteroids
ATC S01GX03 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Other antiallergics

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.98 acidic
pKa2 4.19 acidic
pKa3 5.16 acidic
pKa4 12.86 acidic
pKa5 13.92 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Metabotropic glutamate receptor 3 GPCR AGONIST Ki 4.70 IUPHAR

External reference:

IDSource
D07374 KEGG_DRUG
C3657199 UMLSCUI
CHEBI:135289 CHEBI
CHEMBL2105616 ChEMBL_ID
210320 PUBCHEM_CID
4308 INN_ID
DB08835 DRUGBANK_ID
X81L78B3RB UNII

Pharmaceutical products:

None