cetirizine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diphenylmethyl piperazine derivatives 581 83881-51-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cetirizine
  • cetirizine hydrochloride
  • cetirizine dihydrochloride
  • cetirizine HCl
A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
  • Molecular weight: 388.89
  • Formula: C21H25ClN2O3
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 53.01
  • ALOGS: -3.77
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 5 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.37 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.237 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.600 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 11.995 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 2.404 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 12.250 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 15.160 % High 1
herg hERG pIC50 4.701 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.259 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.258 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 13.650 % High 1
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K7,MAPK14,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1,ZAP70 29
kinase-selectivity-class AXL,GRK2 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 8.670 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.296 High 1
mh-clint Mouse hepatocyte intrinsic clearance 11.885 High 1
mppb Mouse plasma protein binding (% unbound) 17.950 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 5.888 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 Moderate 0.76
pppb Pig plasma protein binding (% unbound) 17.710 % High 1
rat-kpuu-brain Rat brain Kpuu 0.062 % High 1
rh-clint Rat hepatocyte intrinsic clearance 3.899 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 87.090 % High 1
rppb Rat plasma protein binding (% unbound) 17.410 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 912.011 uM High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 8, 1995 FDA J AND J CONSUMER INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2768.95 10.32 6490 600282 320374 89701301
Systemic lupus erythematosus 2514.02 10.32 6662 600110 355234 89666441
Glossodynia 2436.04 10.32 6119 600653 315660 89706015
Hand deformity 1931.24 10.32 5331 601441 291031 89730644
Abdominal discomfort 1690.81 10.32 6993 599779 470335 89551340
Wound 1667.06 10.32 5131 601641 297849 89723826
Swelling 1614.37 10.32 6303 600469 412755 89608920
Alopecia 1612.02 10.32 7070 599702 488001 89533674
Pericarditis 1546.70 10.32 4640 602132 265511 89756164
Anti-cyclic citrullinated peptide antibody positive 1410.27 10.32 4121 602651 232312 89789363
Discomfort 1342.76 10.32 4464 602308 269871 89751804
Contraindicated product administered 1288.79 10.32 4885 601887 315254 89706421
Arthropathy 1245.47 10.32 5302 601470 360940 89660735
Duodenal ulcer perforation 1210.84 10.32 3742 603030 217546 89804129
Helicobacter infection 1124.43 10.32 3708 603064 223142 89798533
Hypersensitivity 1119.91 10.32 5996 600776 448681 89572994
Acute kidney injury 1062.40 10.32 408 606364 319979 89701696
Death 1038.22 10.32 918 605854 455633 89566042
Infusion related reaction 1024.48 10.32 5494 601278 411286 89610389
Synovitis 1011.52 10.32 4630 602142 325122 89696553
Folliculitis 1008.73 10.32 3336 603436 201017 89820658
Hepatic enzyme increased 952.23 10.32 4851 601921 355885 89665790
Blister 948.91 10.32 3797 602975 251201 89770474
Muscle injury 929.72 10.32 2948 603824 173706 89847969
Toxicity to various agents 925.69 10.32 384 606388 287462 89734213
Irritable bowel syndrome 909.00 10.32 3255 603517 204193 89817482
Anaemia 894.04 10.32 636 606136 352166 89669509
Maternal exposure during pregnancy 766.89 10.32 4569 602203 355494 89666181
Impaired healing 762.29 10.32 3348 603424 230851 89790824
Drug interaction 746.52 10.32 464 606308 275989 89745686
Urticaria 742.25 10.32 4085 602687 308649 89713026
Neutropenia 708.58 10.32 309 606463 224595 89797080
Rheumatoid factor positive 696.74 10.32 2628 604144 169022 89852653
Sleep disorder due to general medical condition, insomnia type 675.30 10.32 2146 604626 126548 89895127
Lower respiratory tract infection 665.01 10.32 3377 603395 247282 89774393
Ill-defined disorder 654.67 10.32 2712 604060 182179 89839496
Fall 644.18 10.32 1419 605353 480391 89541284
Rheumatic fever 631.91 10.32 2357 604415 150764 89870911
Joint swelling 619.35 10.32 5602 601170 497698 89523977
Product use issue 596.97 10.32 4017 602755 325902 89695773
Type 2 diabetes mellitus 590.15 10.32 2810 603962 200434 89821241
Hypotension 583.74 10.32 795 605977 324602 89697073
Rash 579.73 10.32 7988 598784 788112 89233563
Pain 537.00 10.32 9502 597270 986839 89034836
Stomatitis 510.78 10.32 3368 603404 271330 89750345
Therapeutic product effect decreased 509.34 10.32 3392 603380 274179 89747496
Sepsis 507.51 10.32 286 606486 179528 89842147
Swollen joint count increased 505.57 10.32 1767 605005 109439 89912236
Completed suicide 484.94 10.32 182 606590 144876 89876799
Disease progression 480.92 10.32 223 606549 156392 89865283
Pruritus 470.45 10.32 5616 601156 535909 89485766
Drug intolerance 457.39 10.32 4793 601979 442798 89578877
Sinusitis 456.24 10.32 3886 602886 339202 89682473
Urinary tract infection 439.34 10.32 863 605909 304769 89716906
Malignant neoplasm progression 433.07 10.32 93 606679 106777 89914898
Psoriatic arthropathy 430.05 10.32 2809 603963 225526 89796149
Liver injury 425.70 10.32 2260 604512 168307 89853368
Febrile neutropenia 420.02 10.32 271 606501 158078 89863597
Blood cholesterol increased 397.18 10.32 2568 604204 205444 89816231
Injury 379 10.32 2440 604332 194909 89826766
Nausea 367.05 10.32 5235 601537 1105081 88916594
Pancytopenia 366.48 10.32 173 606599 120090 89901585
Hyponatraemia 365.96 10.32 220 606552 133318 89888357
Gastrointestinal disorder 359.43 10.32 2942 603830 253745 89767930
Haemoglobin decreased 357.48 10.32 334 606438 161622 89860053
Renal failure 331.63 10.32 236 606536 130771 89890904
Fibromyalgia 321.10 10.32 2423 604349 203846 89817829
Cardiac failure 314.90 10.32 170 606602 109326 89912349
Atrial fibrillation 312.38 10.32 261 606511 133350 89888325
Renal impairment 311.57 10.32 158 606614 105263 89916412
Platelet count decreased 309.97 10.32 276 606496 136693 89884982
Diarrhoea 293.97 10.32 4474 602298 934716 89086959
White blood cell count decreased 291.66 10.32 416 606356 166693 89854982
Hip arthroplasty 291.07 10.32 1145 605627 75063 89946612
Infection 286.17 10.32 3691 603081 358403 89663272
Pneumonia 285.80 10.32 2812 603960 635247 89386428
Dermatitis atopic 285.07 10.32 541 606231 22931 89998744
Sleep disorder 281.56 10.32 2278 604494 195752 89825923
Facet joint syndrome 281.41 10.32 1355 605417 97034 89924641
Dehydration 280.16 10.32 548 606224 193899 89827776
Respiratory failure 279.70 10.32 229 606543 118189 89903486
Depressed level of consciousness 277.76 10.32 72 606700 72712 89948963
Prescribed overdose 269.56 10.32 1331 605441 96294 89925381
Myelosuppression 264.65 10.32 26 606746 53565 89968110
Gastrointestinal haemorrhage 264.10 10.32 137 606635 90111 89931564
Bursitis 260.80 10.32 1641 605131 130013 89891662
Cerebrovascular accident 257.32 10.32 268 606504 123265 89898410
Blood creatinine increased 256.12 10.32 183 606589 101203 89920472
Treatment failure 255.39 10.32 3134 603638 300794 89720881
Metabolic acidosis 255.06 10.32 35 606737 55641 89966034
Lip dry 251.95 10.32 1338 605434 99617 89922058
Cardiac failure congestive 250.81 10.32 177 606595 98517 89923158
Knee arthroplasty 248.38 10.32 1160 605612 82022 89939653
Asthma 246.72 10.32 2593 604179 239567 89782108
Thrombocytopenia 245.05 10.32 657 606115 208068 89813607
Multiple organ dysfunction syndrome 243.43 10.32 77 606695 68259 89953416
Cardiac arrest 241.58 10.32 208 606564 104727 89916948
Food allergy 240.40 10.32 529 606243 24949 89996726
Nasopharyngitis 236.82 10.32 3935 602837 403169 89618506
Seizure 232.32 10.32 416 606356 152213 89869462
Contusion 231.99 10.32 2638 604134 248578 89773097
Off label use 231.95 10.32 5618 601154 1096634 88925041
Intentional overdose 229.73 10.32 175 606597 93659 89928016
Coeliac disease 228.43 10.32 738 606034 43872 89977803
Intentional product use issue 224.95 10.32 2331 604441 214561 89807114
Fatigue 222.14 10.32 9638 597134 1144385 88877290
Cardio-respiratory arrest 221.63 10.32 73 606699 63067 89958608
Weight increased 221.23 10.32 3979 602793 413948 89607727
Night sweats 217.09 10.32 1542 605230 127224 89894451
Joint range of motion decreased 215.27 10.32 1601 605171 134042 89887633
Interstitial lung disease 213.36 10.32 123 606649 76282 89945393
Wheezing 210.40 10.32 2479 604293 235601 89786074
Coma 207.03 10.32 114 606658 72518 89949157
Pulmonary embolism 203.21 10.32 352 606420 130468 89891207
General physical health deterioration 202.59 10.32 3422 603350 351693 89669982
Breast cancer stage III 198.40 10.32 1101 605671 83346 89938329
Septic shock 194.72 10.32 166 606606 83994 89937681
Obesity 189.95 10.32 1284 605488 104223 89917452
Deep vein thrombosis postoperative 189.50 10.32 957 605815 69852 89951823
Neuropathy peripheral 187.05 10.32 398 606374 136572 89885103
Hypokalaemia 186.66 10.32 372 606400 130744 89890931
Leukopenia 186.51 10.32 240 606532 100470 89921205
Somnolence 182.79 10.32 749 606023 208335 89813340
Peripheral swelling 182.23 10.32 3826 602946 409280 89612395
Premature delivery 180.83 10.32 23 606749 38739 89982936
Hyperkalaemia 180.80 10.32 105 606667 64859 89956816
Pleural effusion 180.72 10.32 294 606478 111697 89909978
Myocardial infarction 179.77 10.32 269 606503 105703 89915972
Alanine aminotransferase increased 178.76 10.32 324 606448 118014 89903661
Grip strength decreased 177.78 10.32 1145 605627 91431 89930244
Lactic acidosis 175.96 10.32 59 606713 50404 89971271
Temperature regulation disorder 173.30 10.32 333 606439 14246 90007429
Hypercholesterolaemia 172.84 10.32 1213 605559 99679 89921996
Mobility decreased 172.54 10.32 2494 604278 248240 89773435
Autoimmune disorder 170.67 10.32 986 605786 75758 89945917
Neutrophil count decreased 168.06 10.32 139 606633 71393 89950282
Confusional state 166.46 10.32 3565 603207 382640 89639035
Live birth 164.75 10.32 999 605773 78108 89943567
International normalised ratio increased 163.80 10.32 56 606716 47260 89974415
Herpes zoster 163.71 10.32 237 606535 94407 89927268
Peripheral venous disease 163.01 10.32 1041 605731 82880 89938795
Rhabdomyolysis 161.95 10.32 70 606702 51186 89970489
Adjustment disorder with depressed mood 161.08 10.32 780 605992 55973 89965702
Wound infection 161.00 10.32 1242 605530 105160 89916515
Tremor 160.88 10.32 508 606264 152665 89869010
Cellulitis 159.68 10.32 227 606545 91110 89930565
Electrocardiogram QT prolonged 159.14 10.32 150 606622 72306 89949369
Constipation 158.32 10.32 1162 605610 279233 89742442
Hypoxia 157.70 10.32 151 606621 72248 89949427
Haemorrhage 156.64 10.32 140 606632 69229 89952446
Aspartate aminotransferase increased 156.22 10.32 281 606491 102656 89919019
Drug resistance 155.11 10.32 13 606759 30436 89991239
Mucosal inflammation 154.96 10.32 97 606675 57528 89964147
Hepatic function abnormal 154.76 10.32 58 606714 46230 89975445
Hypoglycaemia 154.11 10.32 144 606628 69704 89951971
Dislocation of vertebra 153.69 10.32 762 606010 55206 89966469
Blood pressure increased 152.19 10.32 740 606032 196477 89825198
Rheumatoid arthritis 151.68 10.32 3333 603439 359281 89662394
Dry mouth 150.14 10.32 1888 604884 182171 89839504
Myalgia 148.92 10.32 634 606138 174491 89847184
Hypercalcaemia 146.68 10.32 26 606746 34214 89987461
Ascites 146.44 10.32 68 606704 47672 89974003
Product dose omission issue 145.59 10.32 1250 605522 290437 89731238
Liver function test abnormal 144.62 10.32 80 606692 50765 89970910
Cytomegalovirus infection 142.26 10.32 9 606763 26593 89995082
Pneumonia aspiration 140.78 10.32 49 606723 40891 89980784
Bone marrow failure 139.05 10.32 24 606748 32197 89989478
Immunodeficiency 138.77 10.32 616 606156 42618 89979057
Skin ulcer 137.84 10.32 82 606690 49993 89971682
Vomiting 134.60 10.32 4136 602636 784157 89237518
Cough 133.60 10.32 1705 605067 367257 89654418
Cataract 131.22 10.32 174 606598 71918 89949757
Pulmonary oedema 131.15 10.32 133 606639 61947 89959728
Blepharospasm 130.96 10.32 724 606048 54721 89966954
Musculoskeletal stiffness 130.50 10.32 2746 604026 293786 89727889
Femur fracture 130.35 10.32 73 606699 46009 89975666
Chronic kidney disease 130.18 10.32 88 606684 50103 89971572
Neoplasm progression 129.45 10.32 68 606704 44418 89977257
Hepatotoxicity 129.13 10.32 73 606699 45769 89975906
Thrombosis 129.09 10.32 181 606591 73070 89948605
Drug abuse 128.39 10.32 221 606551 82126 89939549
Syncope 128.34 10.32 456 606316 132207 89889468
Drug level increased 128.23 10.32 17 606755 27745 89993930
Encephalopathy 126.52 10.32 77 606695 46367 89975308
Shock 125.15 10.32 21 606751 28757 89992918
Bradycardia 122.69 10.32 234 606538 83613 89938062
Osteonecrosis of jaw 122.59 10.32 54 606718 39049 89982626
Hepatic cytolysis 121.02 10.32 29 606743 30887 89990788
Hypoaesthesia 119.49 10.32 2850 603922 311360 89710315
Transaminases increased 118.77 10.32 50 606722 37142 89984533
Blood bilirubin increased 118.51 10.32 72 606700 43398 89978277
Deep vein thrombosis 117.08 10.32 276 606496 91344 89930331
Cystitis 116.43 10.32 166 606606 66552 89955123
Influenza 116.05 10.32 508 606264 138756 89882919
Unresponsive to stimuli 115.84 10.32 55 606717 38066 89983609
Pneumonitis 115.15 10.32 77 606695 44093 89977582
Altered state of consciousness 115.05 10.32 34 606738 31498 89990177
Mental status changes 114.99 10.32 79 606693 44600 89977075
Road traffic accident 114.48 10.32 1163 605609 106463 89915212
Orthostatic hypotension 114.42 10.32 69 606703 41758 89979917
Loss of consciousness 114.18 10.32 516 606256 139722 89881953
Sedation 111.44 10.32 95 606677 48076 89973599
Hyperglycaemia 111.37 10.32 106 606666 50864 89970811
Hypomagnesaemia 110.23 10.32 50 606722 35538 89986137
Hepatic failure 109.43 10.32 65 606707 39663 89982012
Suicide attempt 108.95 10.32 212 606560 75187 89946488
Blood creatine phosphokinase increased 108.23 10.32 46 606726 33977 89987698
Serotonin syndrome 107.19 10.32 60 606712 37827 89983848
Chills 106.62 10.32 487 606285 131494 89890181
Cerebral haemorrhage 106.15 10.32 49 606723 34473 89987202
Influenza like illness 106.10 10.32 239 606533 80372 89941303
Gait inability 103.54 10.32 1464 605308 144992 89876683
Haematuria 102.25 10.32 53 606719 34884 89986791
Acute myocardial infarction 102.01 10.32 53 606719 34837 89986838
Rheumatoid nodule 101.65 10.32 9 606763 20157 90001518
Premature baby 101.20 10.32 22 606750 25055 89996620
Drug ineffective for unapproved indication 101.04 10.32 182 606590 66462 89955213
Lupus vulgaris 100.87 10.32 580 606192 44479 89977196
Exposure during pregnancy 100.73 10.32 2195 604577 236215 89785460
Epistaxis 100.55 10.32 267 606505 84858 89936817
Lower limb fracture 100.38 10.32 939 605833 84074 89937601
Cholestasis 99.13 10.32 60 606712 36239 89985436
Pericardial effusion 99.03 10.32 62 606710 36771 89984904
Agranulocytosis 98.21 10.32 56 606716 34946 89986729
Plasma cell myeloma 97.57 10.32 78 606694 40750 89980925
Melaena 97.17 10.32 56 606716 34741 89986934
Migraine 96.76 10.32 1802 604970 188590 89833085
Posterior reversible encephalopathy syndrome 95.61 10.32 17 606755 22322 89999353
Palmar-plantar erythrodysaesthesia syndrome 95.56 10.32 34 606738 27989 89993686
X-ray abnormal 95.43 10.32 575 606197 44849 89976826
Disseminated intravascular coagulation 95.27 10.32 15 606757 21523 90000152
Aphasia 94.75 10.32 88 606684 42724 89978951
Angina pectoris 94.60 10.32 74 606698 39086 89982589
Lung neoplasm malignant 94.56 10.32 23 606749 24250 89997425
Oxygen saturation decreased 94.53 10.32 384 606388 107099 89914576
Acute myeloid leukaemia 94.47 10.32 13 606759 20627 90001048
Weight decreased 94.40 10.32 1884 604888 378026 89643649
Localised infection 93.73 10.32 54 606718 33508 89988167
Sciatica 93.62 10.32 1065 605707 100317 89921358
Retinitis 93.38 10.32 506 606266 37952 89983723
Proteinuria 92.85 10.32 21 606751 23270 89998405
Neurotoxicity 92.61 10.32 16 606756 21451 90000224
Acute respiratory distress syndrome 92.51 10.32 38 606734 28648 89993027
Pulmonary fibrosis 92.48 10.32 1114 605658 106389 89915286
Respiratory arrest 92.46 10.32 54 606718 33257 89988418
Chronic obstructive pulmonary disease 92.27 10.32 225 606547 73604 89948071
Fracture 91.92 10.32 18 606754 22058 89999617
Hypothyroidism 91.90 10.32 133 606639 52994 89968681
Breast cancer 91.61 10.32 136 606636 53625 89968050
Basal cell carcinoma 91.44 10.32 55 606717 33334 89988341
Gamma-glutamyltransferase increased 91.33 10.32 72 606700 37880 89983795
Hypophagia 90.56 10.32 65 606707 35872 89985803
Asthenia 90.52 10.32 2802 603970 530949 89490726
Psychotic disorder 90.48 10.32 48 606724 31182 89990493
Pulmonary hypertension 89.94 10.32 91 606681 42432 89979243
Cardiac disorder 89.23 10.32 152 606620 56720 89964955
Blood lactate dehydrogenase increased 89.23 10.32 31 606741 25901 89995774
Therapy interrupted 89.10 10.32 123 606649 49985 89971690
Hip fracture 88.49 10.32 56 606716 33021 89988654
Osteomyelitis 88.01 10.32 38 606734 27808 89993867
Leukocytosis 87.79 10.32 49 606723 30941 89990734
Balance disorder 87.16 10.32 344 606428 96736 89924939
Onychomadesis 87.10 10.32 567 606205 45431 89976244
Metastases to liver 86.86 10.32 42 606730 28765 89992910
Adverse event 86.74 10.32 1183 605589 116235 89905440
Foetal exposure during pregnancy 86.38 10.32 96 606676 42879 89978796
Creatinine renal clearance decreased 86.28 10.32 12 606760 18887 90002788
Generalised tonic-clonic seizure 85.53 10.32 65 606707 34838 89986837
Metastases to central nervous system 85.34 10.32 9 606763 17533 90004142
Bacteraemia 85.19 10.32 22 606750 22278 89999397
Blood pressure systolic increased 84.34 10.32 164 606608 58181 89963494
Blood pressure decreased 83.92 10.32 241 606531 74654 89947021
Upper gastrointestinal haemorrhage 83.42 10.32 25 606747 22951 89998724
C-reactive protein abnormal 83.04 10.32 1256 605516 126173 89895502
Cerebral infarction 82.95 10.32 37 606735 26559 89995116
C-reactive protein 82.54 10.32 422 606350 30945 89990730
Diabetes mellitus 82.43 10.32 196 606576 64679 89956996
Thrombotic microangiopathy 82.21 10.32 6 606766 15737 90005938
Agitation 81.89 10.32 207 606565 66891 89954784
Acute respiratory failure 81.82 10.32 100 606672 42818 89978857
Lethargy 81.63 10.32 189 606583 62950 89958725
Pancreatitis acute 81.04 10.32 58 606714 32057 89989618
Abdominal pain upper 80.72 10.32 2852 603920 329822 89691853
Taste disorder 80.43 10.32 695 606077 60851 89960824
Peritonitis 80.11 10.32 17 606755 19688 90001987
Dyspnoea exertional 79.98 10.32 234 606538 72054 89949621
Hemiparesis 79.60 10.32 58 606714 31761 89989914
Diverticulitis 79.27 10.32 112 606660 45075 89976600
Skin necrosis 79.15 10.32 10 606762 16931 90004744
Wrong technique in product usage process 78.95 10.32 232 606540 71339 89950336
Haematoma 78.73 10.32 87 606685 38961 89982714
Metastases to bone 78.73 10.32 36 606736 25469 89996206
Extrapyramidal disorder 77.70 10.32 9 606763 16294 90005381
Oedema peripheral 77.69 10.32 1236 605536 256679 89764996
Vision blurred 77.62 10.32 427 606345 109866 89911809
Renal tubular necrosis 77.61 10.32 5 606767 14550 90007125
Abdominal pain 77.02 10.32 2038 604734 393683 89627992
Neoplasm malignant 76.93 10.32 68 606704 33812 89987863
Ear pain 76.67 10.32 654 606118 57048 89964627
Product prescribing error 76.65 10.32 54 606718 30091 89991584
Pain in jaw 76.43 10.32 127 606645 47858 89973817
Anti-cyclic citrullinated peptide antibody 75.71 10.32 372 606400 26849 89994826
Therapy cessation 75.56 10.32 79 606693 36282 89985393
Osteonecrosis 75.04 10.32 41 606731 26200 89995475
Tubulointerstitial nephritis 74.83 10.32 38 606734 25305 89996370
Cardiogenic shock 74.81 10.32 35 606737 24433 89997242
Blood pressure fluctuation 74.32 10.32 149 606623 52264 89969411
Haematemesis 73.84 10.32 70 606702 33656 89988019
Cholelithiasis 73.82 10.32 150 606622 52356 89969319
Blood glucose increased 73.65 10.32 357 606415 94889 89926786
Renal disorder 73.46 10.32 87 606685 37772 89983903
Acute hepatic failure 72.57 10.32 30 606742 22531 89999144
Nail disorder 72.54 10.32 658 606114 58409 89963266
Clostridium difficile colitis 71.73 10.32 45 606727 26661 89995014
Cardiomyopathy 71.54 10.32 23 606749 20183 90001492
Panniculitis 71.42 10.32 7 606765 14451 90007224
Arrhythmia 71.25 10.32 108 606664 42224 89979451
Blood potassium decreased 70.87 10.32 132 606640 47595 89974080
Blood calcium decreased 70.46 10.32 59 606713 30123 89991552
Respiratory disorder 70.15 10.32 703 606069 64113 89957562
Stress cardiomyopathy 70.00 10.32 5 606767 13350 90008325
Dysphagia 69.87 10.32 452 606320 111826 89909849
Dysarthria 69.70 10.32 164 606608 54318 89967357
Angioedema 69.42 10.32 702 606070 64174 89957501
Bone disorder 69.27 10.32 34 606738 23086 89998589
Blood parathyroid hormone decreased 68.88 10.32 3 606769 12213 90009462
Unevaluable event 68.66 10.32 167 606605 54681 89966994
Epilepsy 68.59 10.32 847 605925 81359 89940316
Respiratory tract infection 68.48 10.32 187 606585 58891 89962784
Victim of chemical submission 68.30 10.32 49 606723 690 90020985
Sedation complication 68.10 10.32 15 606757 16929 90004746
Electric shock 67.79 10.32 70 606702 1652 90020023
Haematotoxicity 67.76 10.32 4 606768 12531 90009144
Heart rate decreased 67.70 10.32 162 606610 53343 89968332
Clostridium difficile infection 67.48 10.32 86 606686 36159 89985516
Hepatic steatosis 67.40 10.32 89 606683 36856 89984819
Urticaria chronic 66.99 10.32 50 606722 751 90020924
Gangrene 66.98 10.32 5 606767 12871 90008804
Myelodysplastic syndrome 66.91 10.32 28 606744 20875 90000800
Pallor 66.84 10.32 78 606694 34087 89987588
Dyskinesia 66.66 10.32 88 606684 36446 89985229
Electrolyte imbalance 66.60 10.32 38 606734 23707 89997968
Device expulsion 66.25 10.32 107 606665 40779 89980896
Gastric ulcer 66.14 10.32 52 606720 27396 89994279
Inappropriate antidiuretic hormone secretion 65.94 10.32 24 606748 19481 90002194
Drug eruption 65.93 10.32 84 606688 35323 89986352
Status epilepticus 65.92 10.32 22 606750 18852 90002823
Shock haemorrhagic 65.91 10.32 4 606768 12241 90009434
Haematochezia 65.76 10.32 248 606524 70665 89951010
Ejection fraction decreased 65.48 10.32 48 606724 26205 89995470
Mouth ulceration 65.35 10.32 104 606668 39870 89981805
Prescribed underdose 65.22 10.32 779 605993 74240 89947435
Lymphadenopathy 65.01 10.32 130 606642 45645 89976030
Burning sensation 64.81 10.32 213 606559 63239 89958436
Exostosis 64.28 10.32 590 606182 52544 89969131
Insomnia 64.22 10.32 2788 603984 330686 89690989
Eating disorder 64.16 10.32 56 606716 28017 89993658
Accidental overdose 63.89 10.32 57 606715 28216 89993459
Transplant rejection 63.49 10.32 6 606766 12752 90008923
Cytopenia 63.32 10.32 19 606753 17430 90004245
Back pain 63.13 10.32 1628 605144 315547 89706128
Pneumocystis jirovecii pneumonia 62.95 10.32 33 606739 21583 90000092
Ischaemic stroke 62.86 10.32 35 606737 22131 89999544
Drug reaction with eosinophilia and systemic symptoms 62.83 10.32 119 606653 42639 89979036
Labelled drug-drug interaction medication error 62.62 10.32 11 606761 14571 90007104
Cardiospasm 62.53 10.32 95 606677 3351 90018324
Myoclonus 62.45 10.32 25 606747 19143 90002532
Intestinal obstruction 62.23 10.32 95 606677 37036 89984639
Respiratory distress 62.10 10.32 103 606669 38843 89982832
Treatment noncompliance 62.03 10.32 161 606611 51566 89970109
Diabetic ketoacidosis 61.69 10.32 44 606728 24363 89997312
Hypertensive crisis 61.64 10.32 21 606751 17763 90003912
Hemiplegia 61.62 10.32 16 606756 16144 90005531
Arterial occlusive disease 61.55 10.32 6 606766 12440 90009235
Colitis 61.42 10.32 250 606522 69692 89951983
Staphylococcal infection 61.02 10.32 147 606625 48292 89973383
Pain in extremity 60.94 10.32 2432 604340 448097 89573578
Cardiotoxicity 60.47 10.32 4 606768 11385 90010290
Hypertension 60.28 10.32 3689 603083 453843 89567832
Laryngitis 60.11 10.32 561 606211 50192 89971483
Rib fracture 60.09 10.32 53 606719 26382 89995293
Hypervolaemia 59.67 10.32 79 606693 32678 89988997
Bronchiectasis 59.46 10.32 38 606734 22292 89999383
Blood pressure systolic abnormal 59.34 10.32 28 606744 19450 90002225
Deafness 59.02 10.32 39 606733 22475 89999200
Granuloma skin 59.00 10.32 3 606769 10677 90010998
Left ventricular dysfunction 58.93 10.32 13 606759 14656 90007019
Oliguria 58.64 10.32 3 606769 10621 90011054
Polyneuropathy 58.62 10.32 28 606744 19313 90002362
Palmoplantar keratoderma 58.49 10.32 93 606679 3414 90018261
Schizophrenia 58.35 10.32 14 606758 14900 90006775
Haemorrhoids 57.78 10.32 56 606716 26646 89995029
Amnesia 57.20 10.32 1033 605739 107472 89914203
Subdural haematoma 57.09 10.32 20 606752 16625 90005050
Blood pressure diastolic abnormal 56.94 10.32 31 606741 19850 90001825
Device difficult to use 56.86 10.32 23 606749 17502 90004173
Full blood count decreased 56.78 10.32 69 606703 29620 89992055
Ileus 56.55 10.32 20 606752 16526 90005149
Injection site pain 56.53 10.32 820 605952 172879 89848796
Inappropriate schedule of product administration 56.37 10.32 687 606085 149246 89872429
Walking aid user 56.23 10.32 419 606353 35087 89986588
Akathisia 56.19 10.32 5 606767 11154 90010521
Bone pain 56.04 10.32 219 606553 61764 89959911
Skin laceration 55.88 10.32 55 606717 25980 89995695
Anuria 55.88 10.32 15 606757 14803 90006872
Crystal urine present 55.84 10.32 59 606713 1431 90020244
Drug withdrawal syndrome 55.74 10.32 66 606706 28657 89993018
Blood alkaline phosphatase increased 55.12 10.32 153 606619 47926 89973749
Tuberculosis 54.92 10.32 9 606763 12540 90009135
Osteoarthritis 54.59 10.32 1706 605066 194024 89827651
Sleep terror 54.33 10.32 103 606669 4361 90017314
Blood potassium increased 54.31 10.32 36 606736 20713 90000962
Seronegative arthritis 54.19 10.32 254 606518 17980 90003695
Pruritus genital 54.04 10.32 104 606668 4454 90017221
Tooth disorder 53.61 10.32 78 606694 31012 89990663
Metastases to lung 53.52 10.32 20 606752 15971 90005704
Haematocrit decreased 53.45 10.32 126 606646 41706 89979969
Febrile bone marrow aplasia 52.96 10.32 3 606769 9735 90011940
Lupus-like syndrome 52.96 10.32 530 606242 48316 89973359
Maternal exposure timing unspecified 52.69 10.32 293 606479 22190 89999485
Flatulence 52.53 10.32 125 606647 41242 89980433
Tachycardia 52.48 10.32 741 606031 156932 89864743
Motor dysfunction 52.21 10.32 32 606740 19198 90002477
Personality disorder 52.12 10.32 10 606762 12434 90009241
Surgery 52.09 10.32 142 606630 44745 89976930
Neuroleptic malignant syndrome 52.02 10.32 18 606754 15078 90006597
Toxic epidermal necrolysis 51.89 10.32 86 606686 32442 89989233
Hallucination, auditory 51.78 10.32 21 606751 15954 90005721
Coronary artery disease 51.70 10.32 91 606681 33532 89988143
Candida infection 51.63 10.32 93 606679 33964 89987711
Inflammation 51.50 10.32 1563 605209 177029 89844646
Spinal fracture 51.44 10.32 43 606729 21973 89999702
Mitral valve incompetence 51.39 10.32 45 606727 22479 89999196
Dyspepsia 51.32 10.32 1712 605060 196448 89825227
Back injury 51.10 10.32 507 606265 46115 89975560
Gastroenteritis 50.72 10.32 73 606699 29156 89992519
Haemorrhage intracranial 50.68 10.32 19 606753 15143 90006532
Red blood cell count decreased 50.58 10.32 151 606621 46200 89975475
Onychomycosis 50.38 10.32 425 606347 36951 89984724
Musculoskeletal disorder 50.27 10.32 43 606729 21726 89999949
Malnutrition 50.22 10.32 31 606741 18527 90003148
Bone erosion 49.85 10.32 559 606213 52462 89969213
Escherichia infection 49.75 10.32 22 606750 15873 90005802
Nervous system disorder 49.44 10.32 43 606729 21550 90000125
Dementia 49.40 10.32 52 606720 23809 89997866
Rash maculo-papular 49.39 10.32 127 606645 40806 89980869
Nephrolithiasis 49.28 10.32 166 606606 48919 89972756
Therapy partial responder 49.14 10.32 45 606727 21998 89999677
Feeling abnormal 49.14 10.32 805 605967 166430 89855245
Affect lability 49.12 10.32 30 606742 18033 90003642
Spinal compression fracture 49.12 10.32 20 606752 15158 90006517
Coagulopathy 49.07 10.32 50 606722 23239 89998436
Palpitations 48.96 10.32 633 606139 136095 89885580
Abdominal pain lower 48.87 10.32 79 606693 30098 89991577
Breast cancer metastatic 48.87 10.32 20 606752 15112 90006563
Pulmonary toxicity 48.86 10.32 9 606763 11522 90010153
Lung disorder 48.80 10.32 1332 605440 148551 89873124
Liver disorder 48.79 10.32 1109 605663 120160 89901515
Intestinal perforation 48.79 10.32 16 606756 13865 90007810
Product label confusion 48.47 10.32 290 606482 22560 89999115
Hypocalcaemia 48.44 10.32 135 606637 42233 89979442
Gastrointestinal toxicity 48.33 10.32 4 606768 9463 90012212
Urinary sediment present 48.33 10.32 66 606706 2108 90019567
Anticipatory anxiety 48.32 10.32 50 606722 1183 90020492
Klebsiella infection 48.29 10.32 6 606766 10291 90011384
Hallucination, visual 48.17 10.32 50 606722 23042 89998633
Macular degeneration 47.65 10.32 425 606347 37545 89984130
Sopor 47.42 10.32 57 606715 24587 89997088
Cardiac failure acute 47.06 10.32 11 606761 11918 90009757
Bone density decreased 46.90 10.32 29 606743 17316 90004359
Pulmonary mass 46.90 10.32 75 606697 28697 89992978
Right ventricular failure 46.76 10.32 36 606736 19169 90002506
Diffuse large B-cell lymphoma 46.00 10.32 3 606769 8642 90013033
Disorientation 45.80 10.32 147 606625 43967 89977708
Hepatocellular injury 45.79 10.32 77 606695 28881 89992794
Suicidal ideation 45.60 10.32 298 606474 73557 89948118
Osteopenia 45.55 10.32 52 606720 22950 89998725
Atelectasis 45.35 10.32 58 606714 24351 89997324
Oedema 45.08 10.32 1703 605069 198592 89823083
Dysgeusia 44.82 10.32 190 606582 52370 89969305
Gastric disorder 44.72 10.32 98 606674 33286 89988389
Muscle rigidity 44.48 10.32 20 606752 14289 90007386
Torsade de pointes 44.47 10.32 23 606749 15159 90006516
Immunisation 44.46 10.32 64 606708 2149 90019526
Circulatory collapse 44.41 10.32 61 606711 24843 89996832
Urinary incontinence 44.22 10.32 118 606654 37448 89984227
Acidosis 44.21 10.32 15 606757 12721 90008954
Incorrect dose administered 44.05 10.32 328 606444 78602 89943073
Troponin increased 43.80 10.32 17 606755 13264 90008411
Pyelonephritis 43.52 10.32 47 606725 21269 90000406
Renal injury 43.39 10.32 8 606764 10235 90011440
Low birth weight baby 43.24 10.32 6 606766 9461 90012214
Hepatic encephalopathy 43.20 10.32 19 606753 13753 90007922
Iron deficiency anaemia 43.16 10.32 57 606715 23605 89998070
Device malfunction 43.11 10.32 46 606726 20931 90000744
Pathogen resistance 42.64 10.32 3 606769 8112 90013563
Breast cancer stage II 42.56 10.32 392 606380 34942 89986733
Vaginal haemorrhage 42.55 10.32 91 606681 31180 89990495
Drug level decreased 42.53 10.32 7 606765 9723 90011952
Tachypnoea 42.39 10.32 48 606724 21261 90000414
Respiratory depression 42.17 10.32 26 606746 15549 90006126
Ear infection 42.11 10.32 679 606093 69096 89952579
Myocarditis 41.82 10.32 20 606752 13786 90007889
Diabetes mellitus inadequate control 41.82 10.32 38 606734 18646 90003029
Brain oedema 41.81 10.32 33 606739 17352 90004323
Eye pruritus 41.77 10.32 335 606437 28692 89992983
Enteritis 41.76 10.32 9 606763 10312 90011363
Faeces discoloured 41.36 10.32 49 606723 21271 90000404
Rash erythematous 41.36 10.32 639 606133 64465 89957210
Oral pain 41.31 10.32 99 606673 32584 89989091
Bacterial infection 41.23 10.32 58 606714 23386 89998289
Dysstasia 41.12 10.32 65 606707 24987 89996688
Hypoalbuminaemia 41.05 10.32 28 606744 15869 90005806
Device issue 40.99 10.32 85 606687 29452 89992223
Overdose 40.96 10.32 776 605996 156933 89864742
Hypothermia 40.80 10.32 27 606745 15548 90006127
Lymphoma 40.70 10.32 20 606752 13571 90008104
Encephalitis 40.63 10.32 12 606760 11122 90010553
Haemoglobin urine present 40.59 10.32 37 606735 745 90020930
Oral allergy syndrome 40.43 10.32 18 606754 91 90021584
Spinal pain 40.41 10.32 28 606744 15739 90005936
Haemophagocytic lymphohistiocytosis 40.22 10.32 27 606745 15432 90006243
Caesarean section 40.15 10.32 39 606733 18538 90003137
Second primary malignancy 40.10 10.32 10 606762 10368 90011307
Chronic spontaneous urticaria 40.08 10.32 55 606717 1765 90019910
Ventricular fibrillation 40.08 10.32 22 606750 14022 90007653
Accidental exposure to product 40.04 10.32 147 606625 42219 89979456
Tricuspid valve incompetence 39.93 10.32 32 606740 16699 90004976
Tenosynovitis 39.88 10.32 24 606748 14543 90007132
Adjustment disorder 39.85 10.32 8 606764 9634 90012041
Hypomania 39.80 10.32 6 606766 8891 90012784
Pneumothorax 39.42 10.32 42 606730 19125 90002550
Intentional self-injury 39.39 10.32 86 606686 29248 89992427
Gastritis 39.38 10.32 145 606627 41608 89980067
Adverse drug reaction 39.38 10.32 1042 605730 115659 89906016
Full blood count abnormal 39.37 10.32 120 606652 36477 89985198
Multiple sclerosis relapse 39.31 10.32 198 606574 52107 89969568
Mental disorder 39.20 10.32 100 606672 32218 89989457
Finger deformity 39.14 10.32 364 606408 32533 89989142
Fistula 39.00 10.32 16 606756 12073 90009602
Haemodynamic instability 38.75 10.32 15 606757 11724 90009951
Enthesopathy 38.46 10.32 8 606764 9396 90012279
Injection site erythema 38.30 10.32 448 606324 98054 89923621
Premature labour 38.10 10.32 21 606751 13355 90008320
Epstein-Barr virus infection 38.02 10.32 11 606761 10333 90011342
Memory impairment 37.69 10.32 1648 605124 195596 89826079
Hydronephrosis 37.52 10.32 18 606754 12384 90009291
Breast cancer female 37.41 10.32 27 606745 14859 90006816
Femoral neck fracture 37.39 10.32 11 606761 10222 90011453
Disease recurrence 37.35 10.32 128 606644 37525 89984150
Dysuria 37.05 10.32 137 606635 39264 89982411
Speech disorder 36.92 10.32 168 606604 45417 89976258
Metastases to lymph nodes 36.86 10.32 16 606756 11673 90010002
Sensory loss 36.74 10.32 40 606732 18035 90003640
Faecaloma 36.71 10.32 12 606760 10419 90011256
Vertigo 36.66 10.32 295 606477 69516 89952159
Dialysis 36.54 10.32 15 606757 11314 90010361
Pregnancy 36.40 10.32 601 606171 61446 89960229
Heart rate irregular 36.13 10.32 67 606705 24201 89997474
Parkinsonism 36.02 10.32 25 606747 14040 90007635
Anosmia 36.00 10.32 146 606626 9702 90011973
Head injury 35.94 10.32 99 606673 31089 89990586
Renal cyst 35.93 10.32 21 606751 12929 90008746
Glaucoma 35.85 10.32 52 606720 20703 90000972
Urinary retention 35.65 10.32 131 606641 37613 89984062
Nephropathy 35.49 10.32 9 606763 9226 90012449
Hypoacusis 35.49 10.32 84 606688 27766 89993909
Blood sodium decreased 35.41 10.32 83 606689 27530 89994145
Haemoptysis 35.32 10.32 110 606662 33210 89988465
Enterocolitis 35.31 10.32 13 606759 10477 90011198
Poisoning 35.21 10.32 30 606742 15187 90006488
Electrocardiogram QRS complex prolonged 35.16 10.32 4 606768 7344 90014331
Pneumonia bacterial 35.12 10.32 21 606751 12769 90008906
Cardiac murmur 35.10 10.32 42 606730 18152 90003523
Foot fracture 34.91 10.32 79 606693 26527 89995148
Humerus fracture 34.89 10.32 11 606761 9774 90011901
Kidney infection 34.78 10.32 76 606696 25840 89995835
Blood urea increased 34.70 10.32 97 606675 30316 89991359
Diarrhoea haemorrhagic 34.59 10.32 14 606758 10649 90011026
Hypernatraemia 34.47 10.32 10 606762 9377 90012298
Splenomegaly 34.40 10.32 22 606750 12902 90008773
Muscle spasticity 34.39 10.32 375 606397 34947 89986728
Arthralgia 34.32 10.32 5819 600953 772703 89248972
Impaired work ability 33.80 10.32 48 606724 19278 90002397
Peripheral sensory neuropathy 33.70 10.32 10 606762 9240 90012435
Antinuclear antibody positive 33.65 10.32 10 606762 9231 90012444
Intestinal ischaemia 33.48 10.32 9 606763 8874 90012801
Immune reconstitution inflammatory syndrome 33.14 10.32 4 606768 7015 90014660
Lymphocyte percentage decreased 33.05 10.32 68 606704 3059 90018616
Fungal infection 32.92 10.32 160 606612 42501 89979174
Mental impairment 32.89 10.32 38 606734 16682 90004993
Hot flush 32.82 10.32 248 606524 59240 89962435
White blood cells urine positive 32.80 10.32 107 606665 6391 90015284
Visual acuity reduced 32.80 10.32 67 606705 23343 89998332
Drug tolerance 32.80 10.32 219 606553 17697 90003978
Sudden death 32.75 10.32 16 606756 10893 90010782
Device related infection 32.68 10.32 78 606694 25708 89995967
Skin discolouration 32.60 10.32 169 606603 44146 89977529
Pulmonary arterial hypertension 32.56 10.32 80 606692 26107 89995568
Tumour lysis syndrome 32.51 10.32 17 606755 11135 90010540
Hyperthyroidism 32.50 10.32 45 606727 18265 90003410
Toxic encephalopathy 32.44 10.32 9 606763 8690 90012985
Restlessness 32.42 10.32 126 606646 35594 89986081
Cyanosis 32.39 10.32 50 606722 19405 90002270
Ataxia 32.36 10.32 44 606728 17998 90003677
Sleep disorder due to a general medical condition 32.31 10.32 449 606323 44289 89977386
Drug dose omission by device 32.27 10.32 14 606758 10217 90011458
Auditory neuropathy spectrum disorder 32.21 10.32 11 606761 22 90021653
Aphthous ulcer 32.20 10.32 41 606731 17246 90004429
Mixed liver injury 32.19 10.32 6 606766 7617 90014058
Blood immunoglobulin E increased 32.13 10.32 83 606689 4342 90017333
Multiple fractures 31.93 10.32 12 606760 9550 90012125
Device dislocation 31.93 10.32 106 606666 31376 89990299
Restrictive pulmonary disease 31.90 10.32 57 606715 2305 90019370
Cholangitis 31.77 10.32 5 606767 7177 90014498
Hospitalisation 31.53 10.32 636 606136 127464 89894211
Abnormal behaviour 31.50 10.32 65 606707 22563 89999112
Limb injury 31.33 10.32 107 606665 31401 89990274
Gastric haemorrhage 31.30 10.32 5 606767 7098 90014577
Blood albumin decreased 31.14 10.32 40 606732 16763 90004912
Dysphonia 31.13 10.32 271 606501 62813 89958862
Joint destruction 31.03 10.32 173 606599 13114 90008561
Oesophagitis 31.01 10.32 42 606730 17207 90004468
Enterococcal infection 31.00 10.32 14 606758 9977 90011698
Tendonitis 30.95 10.32 60 606712 21312 90000363
Vascular device infection 30.93 10.32 21 606751 11931 90009744
Haemodialysis 30.89 10.32 10 606762 8737 90012938
Pollakiuria 30.88 10.32 115 606657 32890 89988785
Unintentional medical device removal 30.86 10.32 5 606767 7025 90014650
Generalised oedema 30.74 10.32 50 606722 19003 90002672
Multiple drug therapy 30.73 10.32 5 606767 7004 90014671
Euglycaemic diabetic ketoacidosis 30.64 10.32 3 606769 6198 90015477
Cytokine release syndrome 30.61 10.32 91 606681 27882 89993793
Product quality issue 30.53 10.32 721 606051 78604 89943071
Apathy 30.49 10.32 18 606754 11022 90010653
Ankylosing spondylitis 30.25 10.32 26 606746 13107 90008568
Hyperlipidaemia 30.10 10.32 68 606704 22848 89998827
Systemic inflammatory response syndrome 30.07 10.32 4 606768 6512 90015163
Atrioventricular block complete 30.05 10.32 14 606758 9797 90011878
Cachexia 29.95 10.32 5 606767 6873 90014802
Skin disorder 29.89 10.32 135 606637 36571 89985104
Prothrombin time prolonged 29.84 10.32 14 606758 9758 90011917
Hepatic cirrhosis 29.82 10.32 592 606180 62661 89959014
Lung infiltration 29.77 10.32 35 606737 15247 90006428
Infusion site reaction 29.76 10.32 224 606548 18815 90002860
Jaundice cholestatic 29.74 10.32 15 606757 10028 90011647
Perfume sensitivity 29.73 10.32 35 606737 960 90020715
Foot deformity 29.72 10.32 563 606209 59088 89962587
Atrial tachycardia 29.67 10.32 98 606674 5892 90015783
Glomerular filtration rate decreased 29.66 10.32 42 606730 16890 90004785
Renal function test abnormal 29.65 10.32 6 606766 7185 90014490
Injection site haemorrhage 29.65 10.32 94 606678 28224 89993451
Joint dislocation 29.64 10.32 441 606331 44141 89977534
Granulocytopenia 29.61 10.32 4 606768 6437 90015238
Sinus tachycardia 29.61 10.32 95 606677 28418 89993257
Body height decreased 29.60 10.32 22 606750 11927 90009748
Small intestinal obstruction 29.56 10.32 61 606711 21173 90000502
Body temperature decreased 29.42 10.32 73 606699 23743 89997932
Drug tolerance decreased 29.41 10.32 337 606435 31793 89989882
Aspergillus infection 29.40 10.32 18 606754 10805 90010870
Hypovolaemia 29.39 10.32 24 606748 12407 90009268
Neonatal hypoacusis 29.28 10.32 10 606762 20 90021655
Cyst 29.09 10.32 41 606731 16520 90005155
Failure to thrive 29.03 10.32 10 606762 8401 90013274
Joint effusion 28.83 10.32 55 606717 19655 90002020
Spinal stenosis 28.80 10.32 45 606727 17379 90004296
Escherichia urinary tract infection 28.72 10.32 30 606742 13785 90007890
Myocardial ischaemia 28.71 10.32 30 606742 13784 90007891
Head deformity 28.71 10.32 16 606756 140 90021535
Neuralgia 28.66 10.32 111 606661 31389 89990286
Pulmonary congestion 28.63 10.32 54 606718 19379 90002296
Lymphoedema 28.44 10.32 30 606742 13723 90007952
Cardiovascular disorder 28.39 10.32 29 606743 13463 90008212
Lymphopenia 28.37 10.32 70 606702 22811 89998864
Toothache 28.36 10.32 67 606705 22163 89999512
Presyncope 28.35 10.32 113 606659 31692 89989983
Hyperthermia 28.33 10.32 17 606755 10318 90011357
COVID-19 28.13 10.32 888 605884 167955 89853720
COVID-19 pneumonia 28.13 10.32 49 606723 18128 90003547
Large intestine perforation 28.03 10.32 15 606757 9697 90011978
Acute coronary syndrome 27.98 10.32 19 606753 10794 90010881
Ulcer 27.95 10.32 119 606653 32763 89988912
Post procedural infection 27.94 10.32 20 606752 11054 90010621
Neutropenic sepsis 27.94 10.32 49 606723 18081 90003594
Eye pain 27.88 10.32 177 606595 43991 89977684
Urine output decreased 27.77 10.32 26 606746 12577 90009098
Metastasis 27.77 10.32 4 606768 6133 90015542
Ulcer haemorrhage 27.76 10.32 284 606488 26037 89995638
Blood pressure abnormal 27.72 10.32 56 606716 19589 90002086
Decubitus ulcer 27.69 10.32 23 606749 11790 90009885
Anal abscess 27.58 10.32 3 606769 5705 90015970
Upper limb fracture 27.56 10.32 65 606707 21513 90000162
Lung opacity 27.56 10.32 4 606768 6098 90015577
Carpal tunnel syndrome 27.53 10.32 76 606696 23852 89997823
Urine leukocyte esterase positive 27.47 10.32 65 606707 3217 90018458
Metabolic disorder 27.35 10.32 8 606764 7462 90014213
Uveitis 27.32 10.32 40 606732 15863 90005812
Colon cancer 27.31 10.32 20 606752 10924 90010751
Hypogammaglobulinaemia 27.30 10.32 19 606753 10655 90011020
Suspected suicide 27.29 10.32 15 606757 9553 90012122
Dystonia 27.26 10.32 44 606728 16775 90004900
Poor venous access 27.26 10.32 56 606716 19471 90002204
Supraventricular tachycardia 27.18 10.32 42 606730 16294 90005381
Haemolytic anaemia 27.14 10.32 23 606749 11674 90010001
Chronic sinusitis 27.14 10.32 261 606511 23541 89998134
Cardiac tamponade 27.11 10.32 3 606769 5629 90016046
Urosepsis 27.08 10.32 64 606708 21168 90000507
Nail operation 27.04 10.32 47 606725 1859 90019816
Amylase increased 26.97 10.32 7 606765 7065 90014610
Polyuria 26.85 10.32 17 606755 10023 90011652
Neutrophil percentage increased 26.81 10.32 61 606711 2942 90018733
Abortion spontaneous 26.77 10.32 232 606540 53824 89967851
Stress 26.55 10.32 384 606388 81011 89940664
Crepitations 26.55 10.32 13 606759 8839 90012836
Pre-eclampsia 26.53 10.32 21 606751 11027 90010648
Malignant melanoma 26.49 10.32 27 606745 12549 90009126
Cognitive disorder 26.47 10.32 317 606455 69090 89952585
Pelvic fracture 26.42 10.32 38 606734 15181 90006494
Atrioventricular block 26.35 10.32 13 606759 8802 90012873
Atrioventricular block first degree 26.29 10.32 12 606760 8499 90013176
Subcutaneous drug absorption impaired 26.27 10.32 168 606604 13377 90008298
Necrosis 26.27 10.32 6 606766 6604 90015071
Musculoskeletal chest pain 26.18 10.32 77 606695 23673 89998002
Hyperbilirubinaemia 26.01 10.32 33 606739 13903 90007772
Injection site extravasation 25.92 10.32 14 606758 9005 90012670
Disability 25.91 10.32 400 606372 40345 89981330
Postoperative wound infection 25.89 10.32 31 606741 13395 90008280
Hypotonia 25.86 10.32 23 606749 11403 90010272
Muscle atrophy 25.71 10.32 12 606760 8389 90013286
Neurological symptom 25.69 10.32 7 606765 6840 90014835
Tension headache 25.63 10.32 109 606663 7400 90014275
Carotid artery occlusion 25.60 10.32 97 606675 6245 90015430
Arteriosclerosis 25.60 10.32 21 606751 10832 90010843
Delusion 25.59 10.32 33 606739 13807 90007868
Lipase increased 25.59 10.32 22 606750 11089 90010586
Pancreatic carcinoma 25.58 10.32 12 606760 8365 90013310
Stillbirth 25.43 10.32 9 606763 7434 90014241
Vocal cord dysfunction 25.42 10.32 31 606741 883 90020792
Complication associated with device 25.31 10.32 58 606714 19391 90002284
Urticaria thermal 25.31 10.32 24 606748 509 90021166
Product use in unapproved indication 25.26 10.32 2596 604176 333640 89688035
Myopathy 25.24 10.32 32 606740 13486 90008189
Ovarian cancer 25.24 10.32 7 606765 6760 90014915
Heparin-induced thrombocytopenia 25.15 10.32 3 606769 5309 90016366
End stage renal disease 25.08 10.32 13 606759 8558 90013117
Poisoning deliberate 25.00 10.32 45 606727 16441 90005234
Red blood cells urine positive 24.99 10.32 62 606710 3163 90018512
Pleuritic pain 24.97 10.32 20 606752 10441 90011234
Pathological fracture 24.96 10.32 17 606755 9643 90012032
Congestive cardiomyopathy 24.94 10.32 9 606763 7345 90014330
Dissociation 24.94 10.32 7 606765 6708 90014967
Nephrotic syndrome 24.86 10.32 9 606763 7330 90014345
Mast cell activation syndrome 24.86 10.32 41 606731 1553 90020122
Injection site bruising 24.80 10.32 227 606545 52080 89969595
Haemolysis 24.77 10.32 13 606759 8497 90013178
Tardive dyskinesia 24.74 10.32 22 606750 10908 90010767
Post cholecystectomy syndrome 24.69 10.32 30 606742 851 90020824
Blood lactic acid increased 24.69 10.32 14 606758 8764 90012911
Aortic stenosis 24.69 10.32 6 606766 6330 90015345
Bedridden 24.56 10.32 27 606745 12121 90009554
Transfusion 24.55 10.32 50 606722 17438 90004237
Porphyria acute 24.54 10.32 205 606567 17770 90003905
Cholecystitis 24.53 10.32 48 606724 16992 90004683
Hyper IgE syndrome 24.48 10.32 23 606749 482 90021193
Pancreatitis 24.35 10.32 325 606447 69501 89952174
Nystagmus 24.25 10.32 9 606763 7218 90014457
Aggression 24.25 10.32 94 606678 26574 89995101
Skin cancer 24.22 10.32 33 606739 13486 90008189
Electrocardiogram abnormal 24.20 10.32 20 606752 10278 90011397
Venous thrombosis 24.17 10.32 4 606768 5533 90016142
Blood pressure diastolic decreased 24.11 10.32 95 606677 26731 89994944
Oropharyngeal pain 24.02 10.32 587 606185 114600 89907075
Product substitution issue 24.01 10.32 53 606719 17955 90003720
Stevens-Johnson syndrome 23.95 10.32 108 606664 29268 89992407
Heart rate increased 23.92 10.32 574 606198 112328 89909347
Lower gastrointestinal haemorrhage 23.86 10.32 15 606757 8877 90012798
Post procedural complication 23.81 10.32 58 606714 18984 90002691
Pulmonary haemorrhage 23.68 10.32 12 606760 8001 90013674
Body temperature increased 23.67 10.32 426 606346 44284 89977391
Drug level below therapeutic 23.67 10.32 5 606767 5809 90015866
Paronychia 23.64 10.32 12 606760 7994 90013681
Foetal growth restriction 23.59 10.32 17 606755 9363 90012312
Alanine aminotransferase abnormal 23.50 10.32 4 606768 5422 90016253
Skin toxicity 23.50 10.32 8 606764 6771 90014904
Facial pain 23.45 10.32 160 606612 13022 90008653
Sinus node dysfunction 23.42 10.32 4 606768 5408 90016267
Spinal osteoarthritis 23.42 10.32 59 606713 19089 90002586
Bronchopulmonary aspergillosis 23.42 10.32 25 606747 11373 90010302
Lip swelling 23.40 10.32 376 606396 38234 89983441
Victim of sexual abuse 23.39 10.32 26 606746 669 90021006
Compression fracture 23.34 10.32 15 606757 8774 90012901
Intervertebral discitis 23.33 10.32 75 606697 4445 90017230
Erysipelas 23.30 10.32 16 606756 9036 90012639
Amyloid arthropathy 23.28 10.32 41 606731 1639 90020036
Nerve injury 23.22 10.32 24 606748 11082 90010593
Post-traumatic stress disorder 23.22 10.32 99 606673 6729 90014946
Hyperuricaemia 23.17 10.32 8 606764 6711 90014964
Urine abnormality 23.15 10.32 108 606664 7629 90014046
Irritability 22.98 10.32 142 606630 35520 89986155
Genital haemorrhage 22.91 10.32 15 606757 8687 90012988
Incontinence 22.87 10.32 34 606738 13401 90008274
Mastocytosis 22.75 10.32 30 606742 926 90020749
Urine odour abnormal 22.71 10.32 10 606762 7234 90014441
Activated partial thromboplastin time prolonged 22.71 10.32 12 606760 7813 90013862
Cardiomegaly 22.61 10.32 59 606713 18866 90002809
Device use error 22.59 10.32 10 606762 7211 90014464
Bronchitis 22.50 10.32 817 605955 152110 89869565
Abscess 22.49 10.32 59 606713 18832 90002843
Oligohydramnios 22.48 10.32 10 606762 7191 90014484
Leukoencephalopathy 22.47 10.32 3 606769 4870 90016805
Diverticulum intestinal 22.43 10.32 17 606755 9125 90012550
Hepatomegaly 22.42 10.32 34 606738 13292 90008383
Rash pustular 22.41 10.32 13 606759 8036 90013639
Ketoacidosis 22.39 10.32 5 606767 5590 90016085
Arthritis 22.39 10.32 904 605868 166411 89855264
Sarcoidosis 22.39 10.32 23 606749 10650 90011025
Lumbar vertebral fracture 22.29 10.32 11 606761 7447 90014228
Anal incontinence 22.28 10.32 47 606725 16183 90005492
Spondylitis 22.27 10.32 167 606605 14011 90007664
Colitis ischaemic 22.26 10.32 30 606742 12316 90009359
Ovarian cyst 22.25 10.32 52 606720 17266 90004409
Product administration error 22.23 10.32 96 606676 26327 89995348
Hypophosphataemia 22.12 10.32 41 606731 14813 90006862
Blood calcium increased 22.04 10.32 29 606743 12029 90009646
Acute pulmonary oedema 22.03 10.32 19 606753 9561 90012114
Schizoaffective disorder 21.85 10.32 4 606768 5143 90016532
Gastric cancer 21.78 10.32 4 606768 5132 90016543
Thirst 21.69 10.32 48 606724 16247 90005428
Bronchial neoplasm 21.69 10.32 22 606750 508 90021167
Diastolic dysfunction 21.64 10.32 11 606761 7322 90014353
Congenital genital malformation female 21.64 10.32 10 606762 56 90021619
Thyroid disorder 21.59 10.32 55 606717 17730 90003945
Rales 21.58 10.32 46 606726 15781 90005894
Hyperprolactinaemia 21.45 10.32 5 606767 5428 90016247
Product storage error 21.33 10.32 67 606705 20174 90001501
Intervertebral disc degeneration 21.30 10.32 53 606719 17221 90004454
Neoplasm 21.28 10.32 17 606755 8886 90012789
Apnoea 21.25 10.32 19 606753 9395 90012280
Hallucination 21.23 10.32 312 606460 65647 89956028
Therapeutic product effect incomplete 21.19 10.32 1071 605701 192825 89828850
Tenderness 21.18 10.32 100 606672 26768 89994907
Anal fissure 21.18 10.32 5 606767 5380 90016295
Cushingoid 21.13 10.32 23 606749 10372 90011303
Foetal death 21.10 10.32 222 606550 20501 90001174
Salivary hypersecretion 20.94 10.32 18 606754 9074 90012601
Autoimmune hepatitis 20.94 10.32 23 606749 10328 90011347
Wrist fracture 20.82 10.32 46 606726 15578 90006097
Post procedural haemorrhage 20.78 10.32 17 606755 8781 90012894
Arthritis bacterial 20.76 10.32 12 606760 7433 90014242
Mouth haemorrhage 20.61 10.32 16 606756 8485 90013190
Atrial flutter 20.57 10.32 25 606747 10733 90010942
Cystic fibrosis pancreatic 20.29 10.32 9 606763 45 90021630
Ventricular extrasystoles 20.25 10.32 36 606736 13214 90008461
Colitis microscopic 20.23 10.32 27 606745 11132 90010543
Nervousness 20.22 10.32 139 606633 33917 89987758
Immunosuppression 20.14 10.32 31 606741 12046 90009629
Pneumonia fungal 20.08 10.32 11 606761 7020 90014655
Nocturnal fear 19.96 10.32 6 606766 6 90021669
Escherichia sepsis 19.93 10.32 7 606765 5809 90015866
Drug level above therapeutic 19.89 10.32 7 606765 5802 90015873
Intestinal haemorrhage 19.89 10.32 3 606769 4444 90017231
Hypertonia 19.86 10.32 5 606767 5150 90016525
Partial seizures 19.82 10.32 12 606760 7248 90014427
Immobile 19.80 10.32 9 606763 6389 90015286
Hernia 19.71 10.32 41 606731 14190 90007485
Coronary artery occlusion 19.62 10.32 17 606755 8537 90013138
Pseudomonas infection 19.61 10.32 44 606728 14821 90006854
Normochromic normocytic anaemia 19.55 10.32 5 606767 5097 90016578
Cerebral ischaemia 19.50 10.32 12 606760 7184 90014491
Device occlusion 19.47 10.32 20 606752 9262 90012413
Sinus bradycardia 19.39 10.32 54 606718 16898 90004777
Mechanical urticaria 19.31 10.32 22 606750 582 90021093
Uterine cancer 19.30 10.32 6 606766 5379 90016296
Pulmonary alveolar haemorrhage 19.25 10.32 8 606764 5990 90015685
Embolism 19.25 10.32 21 606751 9460 90012215
Dizziness 19.18 10.32 3564 603208 585720 89435955
Eye injury 19.15 10.32 133 606639 10887 90010788
Hepatic lesion 19.14 10.32 7 606765 5666 90016009
Eye haemorrhage 19.11 10.32 24 606748 10156 90011519
Immunosuppressant drug level increased 19.10 10.32 4 606768 4676 90016999
Drug effective for unapproved indication 19.08 10.32 15 606757 7903 90013772
Amniotic fluid index increased 19.02 10.32 11 606761 104 90021571
Retinal detachment 19.02 10.32 11 606761 6811 90014864
Gingival bleeding 18.95 10.32 45 606727 14858 90006817
Hypertriglyceridaemia 18.94 10.32 15 606757 7874 90013801
Blood loss anaemia 18.94 10.32 24 606748 10116 90011559
Vitamin D decreased 18.80 10.32 32 606740 11947 90009728
Concomitant disease aggravated 18.79 10.32 30 606742 11488 90010187
Bacterial sepsis 18.71 10.32 5 606767 4950 90016725
Blood magnesium decreased 18.69 10.32 49 606723 15644 90006031
Sickle cell anaemia with crisis 18.65 10.32 13 606759 7284 90014391
Pneumonia viral 18.52 10.32 19 606753 8804 90012871
Diverticulum 18.43 10.32 33 606739 12080 90009595
Tooth infection 18.40 10.32 71 606701 20099 90001576
Blood creatine increased 18.35 10.32 12 606760 6955 90014720
Wound dehiscence 18.31 10.32 8 606764 5814 90015861
Scleritis 18.31 10.32 6 606766 5202 90016473
Device leakage 18.29 10.32 24 606748 9967 90011708
Pelvic pain 18.26 10.32 48 606724 15309 90006366
Aplasia pure red cell 18.23 10.32 6 606766 5188 90016487
Tumour marker increased 18.23 10.32 8 606764 5799 90015876
Breast cancer recurrent 18.22 10.32 7 606765 5496 90016179
Eye disorder 18.21 10.32 108 606664 27282 89994393
Delirium 18.19 10.32 864 605908 103495 89918180
Transient ischaemic attack 18.11 10.32 193 606579 42983 89978692
Neutropenic colitis 18.07 10.32 3 606769 4140 90017535
Aortic valve incompetence 18.01 10.32 11 606761 6613 90015062
Hypokinesia 17.96 10.32 50 606722 15647 90006028
Groin pain 17.93 10.32 34 606738 12179 90009496
Metastatic neoplasm 17.92 10.32 5 606767 4810 90016865
Swollen joint count 17.83 10.32 109 606663 8544 90013131
Erythema nodosum 17.79 10.32 8 606764 5716 90015959
Serum ferritin increased 17.76 10.32 14 606758 7367 90014308
Squamous cell carcinoma 17.75 10.32 25 606747 10076 90011599
Staphylococcal sepsis 17.74 10.32 22 606750 9361 90012314
Jaundice 17.73 10.32 136 606636 32381 89989294
Hypovolaemic shock 17.65 10.32 13 606759 7081 90014594
Blood glucose fluctuation 17.62 10.32 6 606766 5077 90016598
Breath sounds abnormal 17.61 10.32 49 606723 15337 90006338
Nasal turbinate hypertrophy 17.58 10.32 26 606746 895 90020780
Organising pneumonia 17.55 10.32 15 606757 7582 90014093
Central nervous system lesion 17.47 10.32 32 606740 11614 90010061
Personality change 17.47 10.32 14 606758 7307 90014368
Renal cancer 17.42 10.32 9 606763 5936 90015739
Blood pressure inadequately controlled 17.40 10.32 10 606762 6214 90015461
Blood immunoglobulin A increased 17.38 10.32 31 606741 1252 90020423
Blood iron abnormal 17.33 10.32 3 606769 4017 90017658
Portal hypertension 17.28 10.32 5 606767 4696 90016979
Infective pulmonary exacerbation of cystic fibrosis 17.25 10.32 123 606649 10156 90011519
Eosinophilic colitis 17.21 10.32 14 606758 240 90021435
Lung neoplasm 17.21 10.32 12 606760 6723 90014952
Endophthalmitis 17.19 10.32 5 606767 4680 90016995
Gastrointestinal perforation 17.08 10.32 4 606768 4328 90017347
Withdrawal syndrome 17.07 10.32 85 606687 22439 89999236
Hospice care 17.07 10.32 24 606748 9680 90011995
Feeding disorder 17.05 10.32 60 606712 17452 90004223
Inflammatory marker increased 17.01 10.32 22 606750 9192 90012483
Staphylococcal bacteraemia 16.95 10.32 15 606757 7454 90014221
Hypercapnia 16.92 10.32 12 606760 6665 90015010
Clostridial infection 16.91 10.32 5 606767 4631 90017044
Supraventricular extrasystoles 16.89 10.32 7 606765 5250 90016425
Hereditary angioedema 16.86 10.32 114 606658 9251 90012424
Soft tissue disorder 16.84 10.32 4 606768 4286 90017389
Adenovirus infection 16.83 10.32 5 606767 4617 90017058
Toxic skin eruption 16.77 10.32 52 606720 15722 90005953
Tibia fracture 16.71 10.32 10 606762 6077 90015598
Coronavirus infection 16.69 10.32 8 606764 5507 90016168
Iron deficiency 16.68 10.32 24 606748 9588 90012087
Gastrointestinal pain 16.63 10.32 31 606741 11175 90010500
No adverse event 16.58 10.32 338 606434 67644 89954031
Cestode infection 16.58 10.32 15 606757 299 90021376
Upper respiratory tract infection 16.54 10.32 1033 605739 127285 89894390
Oral herpes 16.54 10.32 144 606628 33380 89988295
Ankle fracture 16.54 10.32 75 606697 20295 90001380
Hepatic cancer 16.51 10.32 6 606766 4875 90016800
Endocarditis 16.48 10.32 14 606758 7099 90014576
Varicella zoster virus infection 16.48 10.32 3 606769 3874 90017801
Monocyte count abnormal 16.47 10.32 14 606758 256 90021419
Urine analysis abnormal 16.46 10.32 74 606698 5147 90016528
Haemoglobin abnormal 16.42 10.32 14 606758 7086 90014589
Bronchial haemorrhage 16.33 10.32 21 606751 632 90021043
Rhinorrhoea 16.31 10.32 458 606314 87858 89933817
Rash vesicular 16.27 10.32 190 606582 18007 90003668
Cardiopulmonary failure 16.25 10.32 4 606768 4184 90017491
Sensory disturbance 16.25 10.32 51 606721 15362 90006313
Respiratory tract congestion 16.21 10.32 112 606660 27298 89994377
Breast pain 16.20 10.32 28 606744 10390 90011285
Eosinophilia 16.19 10.32 118 606654 28415 89993260
Fine motor skill dysfunction 16.19 10.32 8 606764 5411 90016264
Oral pruritus 16.18 10.32 50 606722 2901 90018774
Tongue disorder 16.15 10.32 30 606742 10830 90010845
Hyperpathia 16.13 10.32 6 606766 17 90021658
Clostridium test positive 16.09 10.32 8 606764 5393 90016282
Deformity 16.08 10.32 36 606736 12134 90009541
Haemorrhagic stroke 16.04 10.32 12 606760 6484 90015191
Lichen sclerosus 16.04 10.32 31 606741 1332 90020343
Musculoskeletal discomfort 16.04 10.32 79 606693 20912 90000763
Movement disorder 15.99 10.32 121 606651 28898 89992777
Ileus paralytic 15.97 10.32 7 606765 5078 90016597
Chest X-ray abnormal 15.96 10.32 7 606765 5075 90016600
Thrombocytosis 15.96 10.32 14 606758 6987 90014688
Hyperpyrexia 15.86 10.32 6 606766 4755 90016920
Immune-mediated enterocolitis 15.83 10.32 6 606766 4751 90016924
Hiatus hernia 15.82 10.32 102 606670 25259 89996416
Pulseless electrical activity 15.80 10.32 22 606750 8910 90012765
Left ventricular failure 15.76 10.32 13 606759 6687 90014988
Arteriosclerosis coronary artery 15.68 10.32 25 606747 9578 90012097
Metastases to meninges 15.65 10.32 3 606769 3732 90017943
Application site pain 15.63 10.32 6 606766 4714 90016961
Gastric ulcer haemorrhage 15.63 10.32 8 606764 5303 90016372
Aortic arteriosclerosis 15.62 10.32 17 606755 7667 90014008
Phlebitis 15.60 10.32 16 606756 7414 90014261
Immune thrombocytopenia 15.58 10.32 42 606730 13284 90008391
Catheter site pain 15.54 10.32 9 606763 5570 90016105
Lung adenocarcinoma 15.47 10.32 9 606763 5556 90016119
Angina unstable 15.43 10.32 15 606757 7128 90014547
Dermatitis acneiform 15.36 10.32 12 606760 6342 90015333
General symptom 15.34 10.32 158 606614 14510 90007165
Odynophagia 15.28 10.32 23 606749 9020 90012655
Herpes simplex 15.25 10.32 28 606744 10153 90011522
Blood glucose decreased 15.25 10.32 93 606679 23336 89998339
Low density lipoprotein increased 15.24 10.32 19 606753 8066 90013609
Emphysema 15.22 10.32 37 606735 12118 90009557
Pulse absent 15.19 10.32 11 606761 6044 90015631
Intervertebral disc protrusion 15.18 10.32 113 606659 27083 89994592
Neutrophilia 15.16 10.32 10 606762 5768 90015907
Blood phosphorus increased 15.14 10.32 5 606767 4313 90017362
Epigastric discomfort 15.10 10.32 17 606755 7551 90014124
Retinal haemorrhage 15.09 10.32 10 606762 5754 90015921
Stupor 15.05 10.32 9 606763 5473 90016202
Pseudomonal sepsis 15.05 10.32 5 606767 4297 90017378
Peptic ulcer 15.02 10.32 9 606763 5466 90016209
Cold urticaria 14.96 10.32 14 606758 292 90021383
Incorrect dose administered by device 14.95 10.32 10 606762 5727 90015948
Bladder disorder 14.95 10.32 31 606741 10741 90010934
Fibrin D dimer increased 14.94 10.32 9 606763 5451 90016224
Bronchial secretion retention 14.94 10.32 3 606769 3612 90018063
Anaemia macrocytic 14.83 10.32 6 606766 4566 90017109
Pleural fibrosis 14.83 10.32 3 606769 3593 90018082
Tooth abscess 14.83 10.32 58 606714 16355 90005320
Purpura 14.82 10.32 50 606722 14728 90006947
Chemical submission 14.78 10.32 18 606754 512 90021163
Temperature intolerance 14.76 10.32 134 606638 11896 90009779
Streptococcal sepsis 14.76 10.32 3 606769 3581 90018094
Product adhesion issue 14.75 10.32 8 606764 5134 90016541
Injection site mass 14.74 10.32 87 606685 22003 89999672
Schizophreniform disorder 14.73 10.32 9 606763 95 90021580
Hysterectomy 14.71 10.32 35 606737 11549 90010126
Glycosylated haemoglobin increased 14.70 10.32 54 606718 15508 90006167
Fibrosis 14.69 10.32 11 606761 5941 90015734
Hyperaesthesia 14.68 10.32 31 606741 10671 90011004
Condition aggravated 14.67 10.32 4333 602439 591212 89430463
Hepatitis B 14.55 10.32 6 606766 4513 90017162
Eructation 14.53 10.32 32 606740 10850 90010825
Decreased appetite 14.50 10.32 2256 604516 374284 89647391
Autoimmune haemolytic anaemia 14.50 10.32 10 606762 5635 90016040
Psychomotor retardation 14.41 10.32 7 606765 4782 90016893
Subcutaneous abscess 14.40 10.32 14 606758 6652 90015023
Blood culture positive 14.39 10.32 8 606764 5064 90016611
Polyp 14.37 10.32 18 606754 7626 90014049
Urticaria pressure 14.36 10.32 8 606764 70 90021605
Pharyngitis 14.34 10.32 87 606685 21860 89999815
Periodontitis 14.34 10.32 4 606768 3849 90017826
Tongue ulceration 14.31 10.32 5 606767 4163 90017512
Flank pain 14.31 10.32 73 606699 19149 90002526
Skin plaque 14.29 10.32 115 606657 9860 90011815
Abortion induced 14.25 10.32 37 606735 11851 90009824
Eczema 14.24 10.32 459 606313 52411 89969264
Aspartate aminotransferase 14.18 10.32 21 606751 724 90020951
Foreign body in reproductive tract 14.13 10.32 27 606745 1150 90020525
Hydrocephalus 14.12 10.32 12 606760 6082 90015593
Ischaemia 14.11 10.32 9 606763 5286 90016389
Gastrointestinal motility disorder 14.10 10.32 12 606760 6079 90015596
Needle issue 14.07 10.32 47 606725 13887 90007788
Mood altered 13.99 10.32 63 606709 17081 90004594
Nephrogenic systemic fibrosis 13.98 10.32 5 606767 4103 90017572
Adverse reaction 13.97 10.32 278 606494 29434 89992241
Hepatic cyst 13.95 10.32 14 606758 6554 90015121
Flushing 13.88 10.32 469 606303 88022 89933653
Laryngitis bacterial 13.83 10.32 4 606768 3 90021672
Paraesthesia oral 13.83 10.32 293 606479 31366 89990309
Nocturia 13.82 10.32 30 606742 10225 90011450
Embolic stroke 13.78 10.32 5 606767 4067 90017608
Aortic aneurysm 13.78 10.32 6 606766 4369 90017306
Eye infection 13.77 10.32 49 606723 14205 90007470
Blindness unilateral 13.74 10.32 19 606753 7717 90013958
Ankle arthroplasty 13.74 10.32 46 606726 2785 90018890
Scratch 13.73 10.32 113 606659 9753 90011922
Chronic gastritis 13.71 10.32 4 606768 3737 90017938
Pulmonary thrombosis 13.70 10.32 28 606744 9754 90011921
Duodenal ulcer 13.67 10.32 27 606745 9525 90012150
Escherichia bacteraemia 13.65 10.32 11 606761 5724 90015951
Cytomegalovirus colitis 13.60 10.32 3 606769 3383 90018292
Long QT syndrome 13.59 10.32 5 606767 4032 90017643
Spinal cord compression 13.57 10.32 8 606764 4903 90016772
Respiratory rate increased 13.54 10.32 58 606714 15943 90005732
Peripheral arterial occlusive disease 13.54 10.32 7 606765 4614 90017061
Squamous cell carcinoma of skin 13.53 10.32 18 606754 7431 90014244
Blood triglycerides increased 13.50 10.32 47 606725 13714 90007961
Peritonitis bacterial 13.50 10.32 9 606763 5162 90016513
Pregnancy on contraceptive 13.50 10.32 28 606744 1267 90020408
Bundle branch block left 13.38 10.32 20 606752 7865 90013810
Haemarthrosis 13.36 10.32 5 606767 3989 90017686
Hyperkeratosis 13.36 10.32 16 606756 6912 90014763
Peripheral vascular disorder 13.33 10.32 14 606758 6417 90015258
Joint injury 13.30 10.32 147 606625 32517 89989158
Swollen tongue 13.23 10.32 222 606550 45734 89975941
Blood test abnormal 13.20 10.32 84 606688 20868 90000807
Eye swelling 13.18 10.32 273 606499 29113 89992562
Coma scale abnormal 13.13 10.32 11 606761 5615 90016060
Electrocardiogram ST segment depression 13.12 10.32 3 606769 3300 90018375
Pain of skin 13.11 10.32 165 606607 15917 90005758
Anaphylactic reaction 13.08 10.32 714 606058 86810 89934865
Azotaemia 13.05 10.32 10 606762 5338 90016337
Embolism venous 13.03 10.32 4 606768 3616 90018059
Vitamin B12 increased 13.00 10.32 34 606738 1792 90019883
Meningitis 13.00 10.32 23 606749 8458 90013217
Sacroiliitis 12.95 10.32 6 606766 4213 90017462
Orthopnoea 12.95 10.32 16 606756 6819 90014856
Large intestinal ulcer 12.94 10.32 5 606767 3912 90017763
Pulmonary arterial pressure increased 12.93 10.32 5 606767 3911 90017764
Ligament sprain 12.93 10.32 52 606720 14547 90007128
Malaise 12.85 10.32 3611 603161 582375 89439300
Brain herniation 12.85 10.32 6 606766 4194 90017481
Endometrial ablation 12.84 10.32 24 606748 1005 90020670
Pleural thickening 12.80 10.32 3 606769 3245 90018430
Adrenal insufficiency 12.78 10.32 276 606496 29645 89992030
Uterine haemorrhage 12.77 10.32 8 606764 4744 90016931
White blood cell count abnormal 12.77 10.32 19 606753 7485 90014190
Injury associated with device 12.73 10.32 7 606765 4457 90017218
Illness 12.72 10.32 435 606337 81534 89940141
Sensitisation 12.72 10.32 6 606766 4169 90017506
Atrioventricular block second degree 12.67 10.32 7 606765 4445 90017230
Prevertebral soft tissue swelling of cervical space 12.64 10.32 6 606766 36 90021639
International normalised ratio decreased 12.63 10.32 8 606764 4716 90016959
Aspiration 12.61 10.32 58 606714 15635 90006040
Blood creatinine decreased 12.61 10.32 15 606757 6500 90015175
Metabolic encephalopathy 12.59 10.32 16 606756 6736 90014939
Polymyalgia rheumatica 12.54 10.32 9 606763 4968 90016707
Incoherent 12.54 10.32 9 606763 4968 90016707
Thrombotic thrombocytopenic purpura 12.53 10.32 6 606766 4132 90017543
Dental caries 12.53 10.32 37 606735 11360 90010315
Forced expiratory volume decreased 12.50 10.32 74 606698 5734 90015941
Tendon rupture 12.49 10.32 27 606745 9216 90012459
Hyperammonaemia 12.43 10.32 15 606757 6460 90015215
Intracranial aneurysm 12.39 10.32 7 606765 4391 90017284
Gastrointestinal inflammation 12.35 10.32 16 606756 6680 90014995
Mycobacterium avium complex infection 12.32 10.32 6 606766 4092 90017583
Bundle branch block right 12.31 10.32 11 606761 5442 90016233
Non-small cell lung cancer 12.30 10.32 7 606765 4374 90017301
Total lung capacity decreased 12.28 10.32 5 606767 3790 90017885
Histamine level increased 12.25 10.32 6 606766 39 90021636
Musculoskeletal pain 12.25 10.32 1318 605454 169933 89851742
Macular oedema 12.21 10.32 9 606763 4900 90016775
Hypoproteinaemia 12.19 10.32 3 606769 3139 90018536
Injection site swelling 12.19 10.32 306 606466 59533 89962142
Gingivitis 12.14 10.32 28 606744 9341 90012334
Immune system disorder 12.13 10.32 40 606732 11865 90009810
Grip strength 12.11 10.32 102 606670 8863 90012812
Ulcerative keratitis 12.10 10.32 4 606768 3449 90018226
Hepatic enzyme 12.10 10.32 69 606703 5275 90016400
Platelet count abnormal 12.07 10.32 7 606765 4328 90017347
Asphyxia 12.07 10.32 18 606754 7085 90014590
Tympanic membrane hyperaemia 12.05 10.32 4 606768 7 90021668
Blood disorder 12.05 10.32 21 606751 7769 90013906
Scoliosis 12.05 10.32 26 606746 8881 90012794
Atrial septal defect 12.02 10.32 23 606749 8211 90013464
Autoimmune thyroiditis 12.02 10.32 13 606759 5880 90015795
Gout 12.00 10.32 65 606707 16794 90004881
Poor peripheral circulation 11.94 10.32 6 606766 4019 90017656
Chest discomfort 11.90 10.32 782 605990 137583 89884092
Paraplegia 11.88 10.32 4 606768 3408 90018267
Blood iron decreased 11.84 10.32 71 606701 17888 90003787
Retroperitoneal haemorrhage 11.84 10.32 3 606769 3077 90018598
Hyperphosphataemia 11.83 10.32 5 606767 3706 90017969
Acute psychosis 11.83 10.32 3 606769 3075 90018600
Blood glucose abnormal 11.80 10.32 29 606743 9463 90012212
Spinal fusion surgery 11.77 10.32 130 606642 12153 90009522
Atopy 11.73 10.32 12 606760 280 90021395
Productive cough 11.72 10.32 410 606362 76653 89945022
Cells in urine 11.67 10.32 10 606762 185 90021490
Premature rupture of membranes 11.63 10.32 12 606760 5546 90016129
Arteriospasm coronary 11.63 10.32 10 606762 5040 90016635
Urinary tract infection bacterial 11.61 10.32 15 606757 6270 90015405
Gastritis erosive 11.59 10.32 17 606755 6738 90014937
Aortic valve stenosis 11.59 10.32 7 606765 4233 90017442
Pulmonary pain 11.56 10.32 66 606706 5048 90016627
Therapeutic reaction time decreased 11.55 10.32 5 606767 3653 90018022
Abdominal wall haematoma 11.54 10.32 4 606768 3348 90018327
Fungaemia 11.53 10.32 4 606768 3346 90018329
Areflexia 11.52 10.32 5 606767 3648 90018027
Muscle haemorrhage 11.51 10.32 4 606768 3342 90018333
Photopsia 11.51 10.32 10 606762 5014 90016661
Allergy test positive 11.46 10.32 19 606753 723 90020952
Respirovirus test positive 11.44 10.32 5 606767 24 90021651
Thyroiditis 11.44 10.32 5 606767 3632 90018043
Blood pressure diastolic increased 11.41 10.32 46 606726 12860 90008815
Visual field defect 11.38 10.32 19 606753 7147 90014528
Granulocyte count increased 11.37 10.32 29 606743 1505 90020170
Bradyphrenia 11.35 10.32 21 606751 7591 90014084
Internal haemorrhage 11.33 10.32 15 606757 6205 90015470
Ammonia increased 11.33 10.32 10 606762 4976 90016699
Hypersomnia 11.29 10.32 91 606681 21440 90000235
Abdominal distension 11.25 10.32 738 606034 129863 89891812
Bone lesion 11.24 10.32 16 606756 6421 90015254
Metastases to peritoneum 11.16 10.32 7 606765 4148 90017527
Varicose vein 11.11 10.32 20 606752 7307 90014368
Lichen nitidus 11.07 10.32 8 606764 114 90021561
Pyelonephritis acute 11.06 10.32 12 606760 5420 90016255
Exposure via body fluid 11.04 10.32 17 606755 607 90021068
Renal cell carcinoma 11.04 10.32 6 606766 3845 90017830
Skin hyperpigmentation 11.03 10.32 18 606754 6833 90014842
International normalised ratio abnormal 11.01 10.32 6 606766 3839 90017836
Potentiating drug interaction 11.00 10.32 13 606759 5649 90016026
Hepatitis C 10.99 10.32 13 606759 5647 90016028
Listless 10.98 10.32 4 606768 3245 90018430
Osteolysis 10.97 10.32 5 606767 3545 90018130
Vertigo CNS origin 10.97 10.32 5 606767 27 90021648
Faeces soft 10.95 10.32 21 606751 7490 90014185
Optic neuritis 10.94 10.32 31 606741 9647 90012028
Red cell distribution width decreased 10.94 10.32 36 606736 2160 90019515
Cerebral atrophy 10.93 10.32 13 606759 5633 90016042
Poor quality sleep 10.92 10.32 109 606663 24584 89997091
Bile duct stone 10.92 10.32 7 606765 4100 90017575
Amino acid level decreased 10.91 10.32 7 606765 81 90021594
Oesophageal pain 10.90 10.32 8 606764 4366 90017309
Inadequate analgesia 10.84 10.32 4 606768 3220 90018455
Stab wound 10.84 10.32 7 606765 82 90021593
Oral discomfort 10.83 10.32 35 606737 10448 90011227
Nasal polyps 10.78 10.32 37 606735 10843 90010832
Diabetes insipidus 10.78 10.32 4 606768 3208 90018467
Bradykinesia 10.78 10.32 18 606754 6770 90014905
Mouth breathing 10.75 10.32 9 606763 161 90021514
Neurological decompensation 10.72 10.32 5 606767 3496 90018179
Dyspnoea 10.71 10.32 5548 601224 875407 89146268
Therapy change 10.68 10.32 25 606747 8297 90013378
Lung consolidation 10.65 10.32 10 606762 4830 90016845
Eosinophilic oesophagitis 10.65 10.32 20 606752 841 90020834
Disease complication 10.63 10.32 6 606766 3766 90017909
Bronchopulmonary aspergillosis allergic 10.60 10.32 6 606766 3760 90017915
Platelet count increased 10.56 10.32 89 606683 20770 90000905
Bladder cancer 10.55 10.32 14 606758 5787 90015888
Type 1 diabetes mellitus 10.52 10.32 10 606762 4802 90016873
Thymus disorder 10.52 10.32 12 606760 318 90021357
Venous thrombosis limb 10.51 10.32 5 606767 3457 90018218
Tendon pain 10.51 10.32 6 606766 3742 90017933
Injection site pruritus 10.51 10.32 277 606495 53557 89968118
Impaired gastric emptying 10.49 10.32 47 606725 12762 90008913
Oxygen saturation abnormal 10.49 10.32 8 606764 4280 90017395
Middle insomnia 10.48 10.32 164 606608 16587 90005088
Coronary arterial stent insertion 10.48 10.32 3 606769 2837 90018838
Electrocardiogram ST segment elevation 10.47 10.32 7 606765 4009 90017666
Seasonal allergy 10.46 10.32 214 606558 22769 89998906
Hypoventilation 10.46 10.32 12 606760 5284 90016391
Rectal haemorrhage 10.44 10.32 450 606322 82294 89939381
Rash pruritic 10.40 10.32 447 606325 81767 89939908
Somatic symptom disorder 10.40 10.32 5 606767 3436 90018239
Urinary casts 10.38 10.32 19 606753 783 90020892
Portal vein thrombosis 10.38 10.32 4 606768 3134 90018541
Meniscus injury 10.37 10.32 25 606747 8212 90013463
Synovial fluid analysis 10.35 10.32 3 606769 2815 90018860
Terminal state 10.35 10.32 3 606769 2815 90018860
Systemic infection 10.35 10.32 10 606762 4765 90016910
Sputum discoloured 10.32 10.32 87 606685 20304 90001371

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dermatitis atopic 518.89 10.48 319 85552 12085 42523379
Pruritus 423.04 10.48 1073 84798 187698 42347766
Asthma 393.54 10.48 553 85318 61761 42473703
Urticaria 352.44 10.48 576 85295 73460 42462004
Sleep terror 259.70 10.48 124 85747 2802 42532662
Dry skin 233.85 10.48 379 85492 47959 42487505
Eye pruritus 203.31 10.48 175 85696 11237 42524227
Rash 174.50 10.48 1052 84819 275902 42259562
Lip swelling 167.01 10.48 199 85672 18854 42516610
Pruritus genital 153.19 10.48 84 85787 2555 42532909
Cardiospasm 151.73 10.48 75 85796 1832 42533632
Death 149.54 10.48 471 85400 470714 42064750
Facial pain 146.85 10.48 97 85774 4163 42531301
Eczema 136.74 10.48 246 85625 33840 42501624
Palmoplantar keratoderma 134.31 10.48 73 85798 2181 42533283
Tension headache 118.32 10.48 78 85793 3336 42532128
Anaemia 112.39 10.48 249 85622 280029 42255435
Anosmia 112.29 10.48 89 85782 5087 42530377
Angioedema 110.26 10.48 256 85615 42221 42493243
Sleep disorder due to a general medical condition 110.18 10.48 155 85716 17298 42518166
Atrial tachycardia 106.98 10.48 79 85792 4061 42531403
Carotid artery occlusion 99.42 10.48 76 85795 4118 42531346
Immunisation 98.68 10.48 49 85822 1209 42534255
Pain of skin 94.24 10.48 98 85773 7982 42527482
Sinusitis 92.45 10.48 256 85615 47036 42488428
Disturbance in attention 92.21 10.48 193 85678 29673 42505791
Multiple organ dysfunction syndrome 90.60 10.48 41 85830 96994 42438470
Migraine 87.70 10.48 172 85699 25242 42510222
Product dose omission issue 85.50 10.48 568 85303 153797 42381667
Illness 85.15 10.48 168 85703 24762 42510702
General physical health deterioration 76.90 10.48 116 85755 151130 42384334
Cough 76.65 10.48 617 85254 177486 42357978
Erythema 76.52 10.48 426 85445 108367 42427097
Injection site pain 75.34 10.48 272 85599 57526 42477938
Disease progression 75.16 10.48 108 85763 143548 42391916
Muscle twitching 74.91 10.48 105 85766 11675 42523789
Headache 73.98 10.48 772 85099 238597 42296867
Acute kidney injury 73.93 10.48 436 85435 366901 42168563
Wheezing 72.42 10.48 259 85612 54522 42480942
Infective pulmonary exacerbation of cystic fibrosis 72.39 10.48 84 85787 7734 42527730
Hypersensitivity 70.55 10.48 311 85560 72059 42463405
Impaired quality of life 68.28 10.48 111 85760 14066 42521398
Eye disorder 65.81 10.48 98 85773 11514 42523950
Renal impairment 62.59 10.48 78 85793 110150 42425314
Renal failure 62.28 10.48 122 85749 143604 42391860
Nasal congestion 61.95 10.48 164 85707 29337 42506127
Rash papular 61.73 10.48 96 85775 11715 42523749
Ocular hyperaemia 61.20 10.48 113 85758 15850 42519614
Dry eye 61.01 10.48 111 85760 15395 42520069
Influenza 59.69 10.48 266 85605 61909 42473555
Heart rate increased 57.42 10.48 236 85635 53019 42482445
Anxiety 56.65 10.48 421 85450 118139 42417325
Malignant neoplasm progression 56.18 10.48 82 85789 108318 42427146
Anaphylactic reaction 54.72 10.48 200 85671 42543 42492921
Toxicity to various agents 54.36 10.48 257 85614 228879 42306585
Injection site swelling 53.92 10.48 111 85760 16862 42518602
Skin fissures 53.89 10.48 81 85790 9595 42525869
Monocyte chemotactic protein-1 increased 53.33 10.48 22 85849 346 42535118
Alpha tumour necrosis factor increased 53.04 10.48 22 85849 351 42535113
Fixed eruption 52.81 10.48 42 85829 2412 42533052
Vital capacity decreased 52.34 10.48 24 85847 493 42534971
Accident 52.22 10.48 65 85806 6438 42529026
Feeling abnormal 52.22 10.48 278 85593 69508 42465956
Parathyroid gland enlargement 52.17 10.48 18 85853 167 42535297
Skin exfoliation 51.99 10.48 193 85678 41360 42494104
Anal inflammation 51.97 10.48 40 85831 2189 42533275
Upper respiratory fungal infection 51.33 10.48 18 85853 176 42535288
Myelosuppression 50.57 10.48 10 85861 40451 42495013
Aplastic anaemia 50.44 10.48 90 85781 12294 42523170
Ascites 49.76 10.48 26 85845 56652 42478812
Upper respiratory tract infection 49.56 10.48 192 85679 41981 42493483
Drug interaction 49.43 10.48 325 85546 266674 42268790
Cardiac failure 48.65 10.48 88 85783 106768 42428696
Throat irritation 48.37 10.48 91 85780 12945 42522519
Sepsis 48.20 10.48 222 85649 199112 42336352
Chest discomfort 47.31 10.48 253 85618 63363 42472101
Insomnia 46.71 10.48 402 85469 117851 42417613
Malaise 46.45 10.48 641 85230 211515 42323949
Cardiogenic shock 46.27 10.48 8 85863 35632 42499832
Pericarditis 45.18 10.48 90 85781 13354 42522110
Amnesia 45.13 10.48 143 85728 28294 42507170
Eye irritation 44.50 10.48 81 85790 11237 42524227
Thrombocytopenia 44.19 10.48 215 85656 190064 42345400
Palpitations 41.92 10.48 208 85663 50589 42484875
Potassium wasting nephropathy 41.90 10.48 13 85858 83 42535381
SARS-CoV-2 test negative 41.71 10.48 32 85839 1743 42533721
Drug resistance 41.69 10.48 9 85862 34239 42501225
Skin haemorrhage 41.08 10.48 64 85807 7821 42527643
Throat tightness 40.69 10.48 71 85800 9528 42525936
Discomfort 40.19 10.48 127 85744 25092 42510372
Interstitial lung disease 40.01 10.48 60 85811 78402 42457062
Scratch 39.73 10.48 51 85820 5210 42530254
Swelling face 39.63 10.48 134 85737 27420 42508044
Radiation inflammation 38.90 10.48 25 85846 1023 42534441
COVID-19 38.62 10.48 380 85491 115568 42419896
Forced expiratory volume 38.42 10.48 13 85858 113 42535351
Subarachnoid haemorrhage 38.39 10.48 88 85783 14384 42521080
Product dose omission in error 38.33 10.48 64 85807 8290 42527174
Platelet count decreased 37.37 10.48 148 85723 138433 42397031
Gastrointestinal haemorrhage 37.29 10.48 89 85782 97637 42437827
Fatigue 37.26 10.48 1144 84727 434497 42100967
No adverse event 36.73 10.48 166 85705 38855 42496609
Pancytopenia 36.21 10.48 119 85752 117624 42417840
Pulmonary pain 36.10 10.48 28 85843 1550 42533914
Visual impairment 35.90 10.48 177 85694 42936 42492528
Tinnitus 35.85 10.48 134 85737 28804 42506660
Interleukin level increased 34.50 10.48 22 85849 888 42534576
Eosinophilic oesophagitis 34.14 10.48 20 85851 692 42534772
Tendon disorder 34.06 10.48 38 85833 3351 42532113
Oral pruritus 33.79 10.48 18 85853 516 42534948
Lower respiratory tract infection 33.48 10.48 168 85703 41038 42494426
Alopecia 33.35 10.48 132 85739 29144 42506320
Therapeutic response shortened 33.31 10.48 80 85791 13474 42521990
Respiratory failure 33.18 10.48 139 85732 127993 42407471
Forced expiratory volume decreased 33.08 10.48 57 85814 7573 42527891
Septic shock 33.02 10.48 86 85785 91586 42443878
Diplopia 33.01 10.48 103 85768 20213 42515251
Pleural effusion 32.87 10.48 94 85777 97072 42438392
Blindness 32.84 10.48 95 85776 17883 42517581
Conjunctivitis 32.48 10.48 77 85794 12862 42522602
Flushing 32.26 10.48 154 85717 36874 42498590
Seasonal allergy 32.11 10.48 58 85813 7997 42527467
Proctalgia 32.09 10.48 54 85817 7039 42528425
Rhinorrhoea 32.00 10.48 138 85733 31656 42503808
Ear infection 31.93 10.48 76 85795 12728 42522736
Sinus congestion 31.39 10.48 53 85818 6927 42528537
Neurotoxicity 31.39 10.48 5 85866 23646 42511818
Mydriasis 31.03 10.48 60 85811 8710 42526754
Skin discomfort 30.94 10.48 19 85852 717 42534747
Dysmetropsia 30.89 10.48 8 85863 23 42535441
Crystal urine present 30.51 10.48 16 85855 444 42535020
Phonophobia 30.25 10.48 14 85857 294 42535170
Rash pruritic 30.18 10.48 141 85730 33462 42502002
Infusion site pain 29.81 10.48 45 85826 5350 42530114
Sudden infant death syndrome 29.74 10.48 14 85857 306 42535158
Rash macular 29.65 10.48 88 85783 16803 42518661
Arthralgia 29.24 10.48 578 85293 204660 42330804
Disseminated intravascular coagulation 29.21 10.48 7 85864 24787 42510677
Serotonin syndrome 29.10 10.48 8 85863 25837 42509627
Hypotension 28.59 10.48 357 85514 257274 42278190
Sleep disorder 28.41 10.48 180 85691 47915 42487549
Hyperhidrosis 28.37 10.48 293 85578 90219 42445245
Deep vein thrombosis 27.86 10.48 72 85799 76885 42458579
Cardiac arrest 27.44 10.48 120 85751 109200 42426264
Prostate cancer 27.03 10.48 30 85841 44613 42490851
Therapeutic response decreased 26.69 10.48 146 85725 36866 42498598
Cerebral infarction 26.33 10.48 15 85856 31154 42504310
Penis injury 26.15 10.48 12 85859 247 42535217
Vasculitis 26.05 10.48 89 85782 18305 42517159
Injection site reaction 25.81 10.48 80 85791 15641 42519823
Hepatic function abnormal 25.74 10.48 40 85831 51527 42483937
Completed suicide 25.37 10.48 104 85767 96361 42439103
Rheumatoid arthritis 25.17 10.48 29 85842 42411 42493053
Oropharyngeal pain 25.05 10.48 159 85712 42351 42493113
Mood altered 25.00 10.48 62 85809 10656 42524808
Sinus disorder 24.81 10.48 52 85819 7998 42527466
Abdominal pain upper 24.75 10.48 265 85606 82344 42453120
Shock 24.62 10.48 14 85857 29107 42506357
Neutropenia 24.57 10.48 270 85601 199161 42336303
C-reactive protein increased 24.15 10.48 58 85813 63502 42471962
Bone marrow failure 23.84 10.48 19 85852 33074 42502390
Pulmonary function test decreased 23.78 10.48 42 85829 5690 42529774
Drug intolerance 23.55 10.48 83 85788 80341 42455123
Drug ineffective 23.28 10.48 1036 84835 629161 41906303
Treatment failure 23.12 10.48 58 85813 62566 42472898
Croup infectious 22.98 10.48 14 85857 521 42534943
Pulmonary embolism 22.89 10.48 144 85727 119468 42415996
Cognitive disorder 22.79 10.48 132 85739 34040 42501424
Encephalopathy 22.66 10.48 30 85841 41303 42494161
Nasal oedema 22.62 10.48 12 85859 341 42535123
Shock haemorrhagic 22.56 10.48 3 85868 16239 42519225
International normalised ratio increased 22.51 10.48 39 85832 48129 42487335
Peritonitis 22.47 10.48 5 85866 18628 42516836
Mastocytosis 22.39 10.48 7 85864 46 42535418
Blood creatinine increased 22.33 10.48 130 85741 109873 42425591
Middle insomnia 22.30 10.48 49 85822 7784 42527680
Peripheral swelling 21.89 10.48 278 85593 89992 42445472
Chronic spontaneous urticaria 21.80 10.48 11 85860 281 42535183
Rash erythematous 21.43 10.48 124 85747 31967 42503497
Leukopenia 21.31 10.48 78 85793 74668 42460796
Sinus operation 21.30 10.48 16 85855 844 42534620
Skin irritation 21.14 10.48 47 85824 7527 42527937
Congenital genital malformation 21.02 10.48 9 85862 156 42535308
Tonsillitis 20.99 10.48 27 85844 2764 42532700
Ventricular fibrillation 20.82 10.48 18 85853 30105 42505359
Penile haemorrhage 20.72 10.48 17 85854 1021 42534443
Infusion related reaction 20.57 10.48 200 85671 60606 42474858
Hyperkalaemia 20.38 10.48 88 85783 80370 42455094
Off label use 20.29 10.48 1066 84805 637269 41898195
Bronchial disorder 20.09 10.48 19 85852 1379 42534085
Pulmonary alveolar haemorrhage 19.96 10.48 3 85868 14813 42520651
Memory impairment 19.94 10.48 171 85700 50051 42485413
Intentional dose omission 19.93 10.48 51 85820 8935 42526529
Thrombotic microangiopathy 19.90 10.48 3 85868 14779 42520685
Gastroenteritis viral 19.73 10.48 48 85823 8151 42527313
Activated partial thromboplastin time prolonged 19.72 10.48 4 85867 15899 42519565
Pharyngeal swelling 19.66 10.48 29 85842 3378 42532086
Nasopharyngitis 19.65 10.48 257 85614 83739 42451725
Depressed mood 19.46 10.48 96 85775 23288 42512176
Tic 19.42 10.48 24 85847 2359 42533105
Differentiation syndrome 19.38 10.48 21 85850 1792 42533672
Anger 19.33 10.48 64 85807 12954 42522510
Anomalous pulmonary venous connection 19.15 10.48 8 85863 130 42535334
Food allergy 19.13 10.48 23 85848 2198 42533266
Hyponatraemia 18.98 10.48 123 85748 101339 42434125
Infusion site pruritus 18.91 10.48 17 85854 1156 42534308
Neutrophil count decreased 18.86 10.48 65 85806 63350 42472114
Injection related reaction 18.78 10.48 13 85858 603 42534861
Tachycardia 18.76 10.48 297 85574 100790 42434674
Pneumocystis jirovecii pneumonia 18.72 10.48 14 85857 25167 42510297
Neuroleptic malignant syndrome 18.62 10.48 10 85861 21462 42514002
Arrhythmia 18.52 10.48 33 85838 40284 42495180
Viral infection 18.50 10.48 92 85779 22391 42513073
Hallucination 18.41 10.48 187 85684 57320 42478144
Blood pressure increased 18.37 10.48 298 85573 101630 42433834
Nasal polyps 18.33 10.48 30 85841 3821 42531643
Blood immunoglobulin E increased 18.30 10.48 29 85842 3596 42531868
Aspirin-exacerbated respiratory disease 18.27 10.48 10 85861 303 42535161
Oral allergy syndrome 18.24 10.48 5 85866 19 42535445
Gastric ulcer perforation 18.24 10.48 16 85855 1053 42534411
Haemoglobin decreased 18.08 10.48 175 85696 132296 42403168
Anticholinergic syndrome 18.04 10.48 19 85852 1570 42533894
Neurodermatitis 17.91 10.48 14 85857 784 42534680
Reflux nephropathy 17.85 10.48 5 85866 21 42535443
Poverty of speech 17.76 10.48 9 85862 232 42535232
Nephropathy toxic 17.54 10.48 6 85865 16832 42518632
Transient ischaemic attack 17.35 10.48 122 85749 33617 42501847
Lymphocyte percentage decreased 17.22 10.48 22 85849 2237 42533227
Labelled drug-drug interaction medication error 17.21 10.48 5 85866 15577 42519887
Pulmonary fibrosis 17.19 10.48 17 85854 26664 42508800
Sensorimotor disorder 17.10 10.48 11 85860 451 42535013
Bronchospasm 17.08 10.48 61 85810 12824 42522640
End stage renal disease 17.07 10.48 6 85865 16552 42518912
Specific gravity urine increased 17.07 10.48 8 85863 173 42535291
Rhinitis allergic 17.05 10.48 29 85842 3813 42531651
Acute myeloid leukaemia 17.03 10.48 12 85859 22244 42513220
Metabolic acidosis 16.92 10.48 51 85820 51807 42483657
Injection 16.81 10.48 4 85867 7 42535457
Lacrimation increased 16.74 10.48 57 85814 11701 42523763
Adenoidal hypertrophy 16.70 10.48 8 85863 182 42535282
Abdominal discomfort 16.67 10.48 228 85643 75027 42460437
Swelling of eyelid 16.66 10.48 21 85850 2107 42533357
Lactic acidosis 16.64 10.48 42 85829 45219 42490245
Haematochezia 16.64 10.48 61 85810 58375 42477089
Upper gastrointestinal haemorrhage 16.60 10.48 22 85849 30277 42505187
Cerebral dysgenesis 16.52 10.48 5 85866 29 42535435
Nasal pruritus 16.50 10.48 8 85863 187 42535277
Rhabdomyolysis 16.48 10.48 91 85780 77928 42457536
Neutrophil percentage increased 16.36 10.48 20 85851 1945 42533519
Dizziness 16.30 10.48 635 85236 248619 42286845
Respiratory muscle weakness 16.26 10.48 7 85864 123 42535341
Cytomegalovirus infection 16.18 10.48 25 85846 32281 42503183
Enlarged uvula 16.11 10.48 9 85862 284 42535180
Cerebral haemorrhage 16.07 10.48 34 85837 38932 42496532
Exposure via skin contact 16.06 10.48 33 85838 5005 42530459
Phlebotomy 15.79 10.48 6 85865 75 42535389
Chest pain 15.71 10.48 380 85491 139150 42396314
Pharyngitis streptococcal 15.44 10.48 28 85843 3872 42531592
Hypoglycaemia 15.44 10.48 65 85806 59789 42475675
Eye swelling 15.43 10.48 56 85815 11864 42523600
Haematuria 15.39 10.48 62 85809 57737 42477727
Coronary artery disease 15.35 10.48 56 85815 53664 42481800
Rectal haemorrhage 15.33 10.48 50 85821 49556 42485908
Eye discharge 15.17 10.48 24 85847 2971 42532493
Post-tussive vomiting 15.14 10.48 5 85866 40 42535424
Pseudohallucination 15.14 10.48 5 85866 40 42535424
Sneezing 15.04 10.48 37 85834 6326 42529138
Urticaria chronic 14.95 10.48 7 85864 151 42535313
Growth accelerated 14.85 10.48 4 85867 14 42535450
Frenulum breve 14.85 10.48 4 85867 14 42535450
Swollen tongue 14.80 10.48 83 85788 21148 42514316
Pneumonia acinetobacter 14.78 10.48 8 85863 237 42535227
Hyperleukocytosis 14.76 10.48 22 85849 2586 42532878
Neuralgia 14.70 10.48 18 85853 25629 42509835
Appendicitis 14.64 10.48 12 85859 20601 42514863
Serum sickness-like reaction 14.63 10.48 8 85863 242 42535222
Urine analysis abnormal 14.61 10.48 20 85851 2174 42533290
Patient elopement 14.50 10.48 7 85864 162 42535302
Blister 14.48 10.48 100 85771 27390 42508074
Victim of chemical submission 14.46 10.48 7 85864 163 42535301
Postmortem blood drug level 14.43 10.48 7 85864 164 42535300
Injection site urticaria 14.31 10.48 25 85846 3358 42532106
Genital pain 14.30 10.48 13 85858 897 42534567
Suicidal ideation 14.19 10.48 154 85717 48007 42487457
Eyelid margin crusting 14.18 10.48 11 85860 609 42534855
Food poisoning 14.15 10.48 22 85849 2684 42532780
Agranulocytosis 14.11 10.48 25 85846 30587 42504877
Product administration interrupted 14.07 10.48 31 85840 4935 42530529
Inappropriate antidiuretic hormone secretion 13.91 10.48 8 85863 16533 42518931
Blood phosphorus increased 13.87 10.48 4 85867 12521 42522943
Synovitis 13.87 10.48 7 85864 15560 42519904
Hereditary angioedema 13.86 10.48 16 85855 1465 42533999
Bradycardia 13.85 10.48 108 85763 85376 42450088
Ileus 13.77 10.48 11 85860 19128 42516336
Seizure 13.77 10.48 329 85542 120232 42415232
Micropenis 13.73 10.48 5 85866 55 42535409
Amino acid level increased 13.73 10.48 10 85861 503 42534961
Corneal leukoma 13.71 10.48 4 85867 20 42535444
Depressed level of consciousness 13.71 10.48 50 85821 47920 42487544
Infusion site urticaria 13.62 10.48 7 85864 186 42535278
Craniofacial fracture 13.59 10.48 9 85862 388 42535076
Parenteral nutrition 13.57 10.48 11 85860 649 42534815
Abdominoplasty 13.55 10.48 3 85868 3 42535461
Hepatic failure 13.51 10.48 36 85835 38064 42497400
Cardiac failure congestive 13.48 10.48 109 85762 85493 42449971
Ocular discomfort 13.47 10.48 23 85848 3034 42532430
Skin swelling 13.34 10.48 22 85849 2820 42532644
Respiratory arrest 13.29 10.48 23 85848 28401 42507063
Dystonia 13.24 10.48 56 85815 12734 42522730
Periorbital swelling 13.24 10.48 16 85855 1537 42533927
Incorrect dose administered 13.20 10.48 164 85707 52810 42482654
Attention deficit hyperactivity disorder 13.19 10.48 23 85848 3085 42532379
Social (pragmatic) communication disorder 13.14 10.48 6 85865 122 42535342
Infusion site extravasation 13.09 10.48 32 85839 5449 42530015
Cerebrovascular accident 12.98 10.48 129 85742 97031 42438433
Dermatitis exfoliative 12.97 10.48 37 85834 6910 42528554
Confusional state 12.87 10.48 249 85622 167348 42368116
Hyperventilation 12.80 10.48 23 85848 3159 42532305
Decreased appetite 12.76 10.48 294 85577 192843 42342621
Back pain 12.76 10.48 375 85496 141401 42394063
Skin plaque 12.72 10.48 33 85838 5830 42529634
Melaena 12.72 10.48 38 85833 38708 42496756
Metastases to bone 12.69 10.48 7 85864 14802 42520662
Genital ulceration 12.59 10.48 12 85859 879 42534585
Cardio-respiratory arrest 12.59 10.48 68 85803 58568 42476896
Parkinsonism 12.51 10.48 3 85868 10620 42524844
Haemophagocytic lymphohistiocytosis 12.46 10.48 11 85860 18211 42517253
Blood uric acid increased 12.41 10.48 8 85863 15539 42519925
Pharyngeal paraesthesia 12.39 10.48 12 85859 897 42534567
Transplant rejection 12.27 10.48 6 85865 13582 42521882
Neoplasm progression 12.21 10.48 25 85846 28975 42506489
Progressive multifocal leukoencephalopathy 12.21 10.48 4 85867 11532 42523932
Throat clearing 12.09 10.48 10 85861 607 42534857
Incorrect route of product administration 11.99 10.48 19 85852 24286 42511178
Myelodysplastic syndrome 11.97 10.48 17 85854 22728 42512736
Dermatitis allergic 11.97 10.48 41 85830 8442 42527022
Mental status changes 11.97 10.48 44 85827 42071 42493393
Noninfective gingivitis 11.94 10.48 9 85862 477 42534987
Cardiovascular disorder 11.92 10.48 6 85865 13359 42522105
Hypocalcaemia 11.88 10.48 27 85844 30146 42505318
Crying 11.88 10.48 34 85837 6360 42529104
Oropharyngeal discomfort 11.86 10.48 26 85845 4123 42531341
Pseudoporphyria 11.81 10.48 9 85862 485 42534979
Sluggishness 11.81 10.48 25 85846 3871 42531593
Urethritis noninfective 11.75 10.48 3 85868 8 42535456
Complex regional pain syndrome 11.71 10.48 10 85861 635 42534829
Myocardial oedema 11.67 10.48 7 85864 253 42535211
Mycobacterial infection 11.66 10.48 20 85851 2648 42532816
Periorbital discomfort 11.60 10.48 4 85867 37 42535427
Blood urea nitrogen/creatinine ratio decreased 11.56 10.48 5 85866 89 42535375
Administration site reaction 11.56 10.48 5 85866 89 42535375
Liver disorder 11.54 10.48 41 85830 39603 42495861
Therapy partial responder 11.53 10.48 14 85857 20007 42515457
Orthostatic hypotension 11.53 10.48 28 85843 30542 42504922
Aspergillus infection 11.52 10.48 9 85862 15828 42519636
Temperature intolerance 11.49 10.48 28 85843 4760 42530704
Renal tubular necrosis 11.48 10.48 12 85859 18342 42517122
Blood lactate dehydrogenase increased 11.40 10.48 22 85849 26059 42509405
Multiple allergies 11.39 10.48 24 85847 3704 42531760
Amino acid level decreased 11.39 10.48 6 85865 168 42535296
Psychomotor hyperactivity 11.36 10.48 48 85823 10910 42524554
Proteinuria 11.30 10.48 18 85853 22965 42512499
Blood glucose increased 11.30 10.48 210 85661 73489 42461975
Haematotoxicity 11.29 10.48 4 85867 10981 42524483
Coagulopathy 11.24 10.48 17 85854 22145 42513319
Injection site rash 11.23 10.48 31 85840 5681 42529783
Cystic fibrosis 11.15 10.48 17 85854 2038 42533426
Status epilepticus 11.15 10.48 9 85862 15569 42519895
Hypercapnic coma 11.02 10.48 6 85865 180 42535284
Infusion site swelling 11.01 10.48 22 85849 3270 42532194
Metastases to liver 10.99 10.48 10 85861 16316 42519148
Blood creatine phosphokinase increased 10.97 10.48 55 85816 48283 42487181
Feeling hot 10.97 10.48 83 85788 23399 42512065
Increased upper airway secretion 10.96 10.48 19 85852 2537 42532927
Brugada syndrome 10.92 10.48 12 85859 1041 42534423
Secretion discharge 10.86 10.48 37 85834 7598 42527866
Asthenia 10.83 10.48 459 85412 280334 42255130
Atrial fibrillation 10.83 10.48 207 85664 139386 42396078
Bladder cancer 10.82 10.48 11 85860 17036 42518428
Injection site hypersensitivity 10.75 10.48 8 85863 416 42535048
Tongue spasm 10.75 10.48 4 85867 47 42535417
Obstructive airways disorder 10.73 10.48 86 85785 24673 42510791
Second primary malignancy 10.71 10.48 3 85868 9572 42525892
Injection site discolouration 10.55 10.48 16 85855 1910 42533554

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2058.46 10.51 3732 537230 210838 109837499
Glossodynia 1905.90 10.51 3682 537280 218322 109830015
Systemic lupus erythematosus 1886.37 10.51 3969 536993 250369 109797968
Hand deformity 1802.75 10.51 3564 537398 214942 109833395
Pericarditis 1714.45 10.51 3496 537466 215618 109832719
Anti-cyclic citrullinated peptide antibody positive 1529.35 10.51 2992 537970 178992 109869345
Wound 1471.84 10.51 3423 537539 231014 109817323
Duodenal ulcer perforation 1409.50 10.51 2852 538110 174848 109873489
Helicobacter infection 1325.23 10.51 2819 538143 179058 109869279
Swelling 1314.66 10.51 4239 536723 346802 109701535
Alopecia 1290.23 10.51 4320 536642 360433 109687904
Urticaria 1257.49 10.51 3920 537042 314937 109733400
Acute kidney injury 1245.27 10.51 787 540175 634643 109413694
Hypersensitivity 1238.59 10.51 4564 536398 399434 109648903
Synovitis 1198.62 10.51 3495 537467 270597 109777740
Abdominal discomfort 1156.88 10.51 4389 536573 389469 109658868
Discomfort 1155.44 10.51 2955 538007 211752 109836585
Folliculitis 1133.96 10.51 2522 538440 165131 109883206
Arthropathy 1098.70 10.51 3497 537465 284025 109764312
Irritable bowel syndrome 1057.85 10.51 2423 538539 161792 109886545
Blister 1053.68 10.51 2961 538001 224415 109823922
Death 1038.11 10.51 1134 539828 697735 109350602
Muscle injury 1035.29 10.51 2191 538771 138616 109909721
Infusion related reaction 1008.64 10.51 4111 536851 377051 109671286
Hepatic enzyme increased 992.77 10.51 3637 537325 317255 109731082
Anaemia 961.59 10.51 761 540201 546325 109502012
Toxicity to various agents 912.53 10.51 616 540346 479939 109568398
Contraindicated product administered 899.73 10.51 2966 537996 245301 109803036
Drug interaction 867.29 10.51 705 540257 499478 109548859
Impaired healing 850.39 10.51 2499 538463 194218 109854119
Sleep disorder due to general medical condition, insomnia type 847.19 10.51 1704 539258 103939 109944398
Pruritus 798.02 10.51 5219 535743 576341 109471996
Lower respiratory tract infection 797.99 10.51 2810 538152 240296 109808041
Rheumatoid factor positive 774.28 10.51 1875 539087 129765 109918572
Rheumatic fever 771.92 10.51 1793 539169 120786 109927551
Maternal exposure during pregnancy 733.94 10.51 2824 538138 252059 109796278
Ill-defined disorder 726.57 10.51 2043 538919 154810 109893527
Type 2 diabetes mellitus 717.30 10.51 2200 538762 175032 109873305
Joint swelling 700.96 10.51 4124 536838 438721 109609616
Neutropenia 673.10 10.51 509 540453 374111 109674226
Sinusitis 651.06 10.51 3026 537936 293662 109754675
Rash 636.22 10.51 6468 534494 814496 109233841
Sepsis 595.42 10.51 439 540523 326907 109721430
Hypotension 594.98 10.51 1031 539931 522818 109525519
Swollen joint count increased 573.64 10.51 1266 539696 82395 109965942
Therapeutic product effect decreased 573.28 10.51 2542 538420 241774 109806563
Fibromyalgia 561.79 10.51 1977 538985 168932 109879405
Stomatitis 559.83 10.51 2711 538251 267531 109780806
Drug intolerance 534.28 10.51 3611 537351 402901 109645436
Asthma 529.34 10.51 2526 538436 247765 109800572
Psoriatic arthropathy 520.17 10.51 2123 538839 194638 109853699
Facet joint syndrome 519.58 10.51 1332 539630 95496 109952841
Bursitis 514.63 10.51 1601 539361 128317 109920020
Completed suicide 503.74 10.51 279 540683 242102 109806235
Disease progression 496.98 10.51 288 540674 243746 109804591
Lip dry 485.44 10.51 1326 539636 98757 109949580
Dermatitis atopic 477.65 10.51 607 540355 24934 110023403
Injury 475.96 10.51 1922 539040 175343 109872994
Malignant neoplasm progression 441.76 10.51 151 540811 174416 109873921
Febrile neutropenia 437.02 10.51 544 540418 316223 109732114
Multiple organ dysfunction syndrome 436.09 10.51 103 540859 151607 109896730
Blood cholesterol increased 428.29 10.51 1916 539046 182869 109865468
Renal failure 424.79 10.51 294 540668 226280 109822057
Pancytopenia 421.66 10.51 251 540711 209362 109838975
Renal impairment 416.68 10.51 200 540762 188245 109860092
Liver injury 399.07 10.51 1625 539337 148788 109899549
Fall 398.20 10.51 1561 539401 601921 109446416
Wheezing 387.85 10.51 2353 538609 252877 109795460
Pain 386.19 10.51 6685 534277 948270 109100067
Night sweats 380.76 10.51 1479 539483 132504 109915833
Joint range of motion decreased 378.64 10.51 1384 539578 120448 109927889
Cardiac failure 374.11 10.51 227 540735 187399 109860938
Breast cancer stage III 372.50 10.51 1037 539925 78080 109970257
Gastrointestinal disorder 370.42 10.51 2235 538727 239717 109808620
Thrombocytopenia 368.75 10.51 717 540245 348168 109700169
Platelet count decreased 368.44 10.51 350 540612 230093 109818244
Hyponatraemia 365.36 10.51 316 540646 217337 109831000
Coeliac disease 362.15 10.51 710 540252 42477 110005860
Respiratory failure 359.79 10.51 314 540648 215018 109833319
Nasopharyngitis 339.02 10.51 3178 537784 391183 109657154
Gastrointestinal haemorrhage 331.74 10.51 199 540763 165319 109883018
Haemoglobin decreased 329.71 10.51 440 540522 248287 109800050
Myelosuppression 328.76 10.51 38 540924 94302 109954035
Cardiac arrest 324.98 10.51 290 540672 196463 109851874
Obesity 322.65 10.51 1252 539710 112099 109936238
Peripheral venous disease 322.35 10.51 1025 539937 83092 109965245
Sleep disorder 320.76 10.51 1861 539101 196783 109851554
Atrial fibrillation 312.85 10.51 398 540564 229244 109819093
Dry mouth 312.37 10.51 1857 539105 198091 109850246
Peripheral swelling 299.27 10.51 3157 537805 400877 109647460
Interstitial lung disease 298.76 10.51 154 540808 139180 109909157
Weight increased 296.92 10.51 3249 537713 416395 109631942
Off label use 288.41 10.51 5391 535571 1494794 108553543
Product use issue 287.65 10.51 2551 538411 309144 109739193
Blood creatinine increased 287.40 10.51 282 540680 182607 109865730
Pneumonia 286.28 10.51 2825 538137 873889 109174448
Grip strength decreased 284.74 10.51 952 540010 79222 109969115
Septic shock 283.97 10.51 213 540749 157315 109891022
Deep vein thrombosis postoperative 279.94 10.51 778 540184 58513 109989824
Live birth 278.49 10.51 860 540102 68624 109979713
Food allergy 277.66 10.51 411 540551 19537 110028800
Contusion 273.41 10.51 2017 538945 231344 109816993
Prescribed overdose 273.00 10.51 996 539966 86585 109961752
Wound infection 272.50 10.51 1063 539899 95402 109952935
Mobility decreased 269.62 10.51 2037 538925 235385 109812952
Infection 267.63 10.51 2829 538133 359371 109688966
Hypoaesthesia 265.80 10.51 2524 538438 311699 109736638
Treatment failure 265.14 10.51 2287 538675 274947 109773390
Metabolic acidosis 259.82 10.51 82 540880 99662 109948675
Autoimmune disorder 256.44 10.51 804 540158 64679 109983658
Hip arthroplasty 253.34 10.51 722 540240 55091 109993246
Depressed level of consciousness 249.93 10.51 118 540844 112160 109936177
Migraine 244.62 10.51 1557 539405 170095 109878242
Hyperkalaemia 244.27 10.51 184 540778 135612 109912725
Ascites 244.07 10.51 75 540887 92733 109955604
Blepharospasm 240.70 10.51 701 540261 54150 109994187
Cardio-respiratory arrest 239.59 10.51 134 540828 115702 109932635
Rhabdomyolysis 238.11 10.51 147 540815 120254 109928083
Pulmonary embolism 237.74 10.51 428 540534 214046 109834291
Knee arthroplasty 232.22 10.51 773 540189 64175 109984162
Cardiac failure congestive 230.19 10.51 239 540723 150761 109897576
Temperature regulation disorder 229.10 10.51 298 540664 12528 110035809
Cerebrovascular accident 224.97 10.51 336 540626 180948 109867389
Pleural effusion 224.81 10.51 325 540637 177384 109870953
Sleep terror 224.69 10.51 215 540747 6395 110041942
Hepatic function abnormal 221.12 10.51 80 540882 89215 109959122
Adjustment disorder with depressed mood 220.31 10.51 589 540373 43294 110005043
White blood cell count decreased 216.66 10.51 502 540460 228888 109819449
C-reactive protein abnormal 214.46 10.51 1223 539739 128472 109919865
Urinary tract infection 214.20 10.51 845 540117 325437 109722900
Hypercholesterolaemia 211.91 10.51 944 540018 89893 109958444
Drug resistance 211.46 10.51 17 540945 56357 109991980
International normalised ratio increased 211.06 10.51 80 540882 86692 109961645
Abdominal pain upper 209.89 10.51 2620 538342 346491 109701846
Road traffic accident 208.99 10.51 1059 539903 106339 109941998
Lactic acidosis 208.96 10.51 96 540866 92715 109955622
Sciatica 207.89 10.51 950 540012 91449 109956888
Dislocation of vertebra 205.70 10.51 573 540389 43148 110005189
Lower limb fracture 201.29 10.51 816 540146 74532 109973805
Osteoarthritis 200.08 10.51 1554 539408 181069 109867268
Neutrophil count decreased 185.95 10.51 190 540772 120751 109927586
Inflammation 183.54 10.51 1592 539370 191646 109856691
Cytomegalovirus infection 179.88 10.51 26 540936 54418 109993919
Fatigue 179.83 10.51 7460 533502 1208498 108839839
Exposure during pregnancy 179.72 10.51 1418 539544 166006 109882331
Intentional product use issue 179.08 10.51 1928 539034 245978 109802359
Haematuria 179.03 10.51 91 540871 82914 109965423
Myocardial infarction 178.46 10.51 424 540538 191659 109856678
Onychomadesis 178.18 10.51 560 540402 45103 110003234
Gait inability 177.25 10.51 1209 539753 135167 109913170
Hypoglycaemia 176.69 10.51 184 540778 115920 109932417
Nail disorder 176.44 10.51 654 540308 57281 109991056
Musculoskeletal stiffness 176.35 10.51 2119 538843 277703 109770634
Leukopenia 175.80 10.51 285 540677 148506 109899831
Bone marrow failure 174.88 10.51 35 540927 57813 109990524
Dehydration 173.33 10.51 740 540222 278771 109769566
Cardiospasm 169.67 10.51 162 540800 4805 110043532
Pneumonia aspiration 167.94 10.51 94 540868 81139 109967198
Thrombosis 166.72 10.51 171 540791 108491 109939846
Shock 165.00 10.51 31 540931 53557 109994780
Cardiogenic shock 164.59 10.51 39 540923 57299 109991038
Bradycardia 163.80 10.51 320 540642 155197 109893140
Pruritus genital 161.64 10.51 179 540783 6343 110041994
Insomnia 158.80 10.51 2562 538400 358028 109690309
Haemorrhage 157.99 10.51 173 540789 106519 109941818
Encephalopathy 157.45 10.51 101 540861 80954 109967383
Blood creatine phosphokinase increased 153.34 10.51 83 540879 72994 109975343
Retinitis 152.39 10.51 424 540538 31903 110016434
C-reactive protein 152.14 10.51 407 540555 29924 110018413
Palmoplantar keratoderma 151.36 10.51 158 540804 5229 110043108
Hypoxia 151.21 10.51 250 540712 129265 109919072
Coma 147.64 10.51 217 540745 117652 109930685
Taste disorder 147.61 10.51 673 540289 64714 109983623
Eye pruritus 145.84 10.51 421 540541 32354 110015983
Hypokalaemia 145.05 10.51 435 540527 182013 109866324
Neuropathy peripheral 145.02 10.51 424 540538 178853 109869484
Acute myocardial infarction 142.50 10.51 120 540842 83657 109964680
Adverse event 141.61 10.51 965 539997 107844 109940493
Somnolence 141.54 10.51 863 540099 296586 109751751
Diarrhoea 140.21 10.51 4377 536585 1135128 108913209
Hepatic failure 140.01 10.51 81 540881 68658 109979679
Intentional overdose 139.23 10.51 273 540689 132228 109916109
X-ray abnormal 138.33 10.51 456 540506 37661 110010676
Disseminated intravascular coagulation 138.08 10.51 19 540943 41267 110007070
Blood bilirubin increased 137.82 10.51 102 540860 75870 109972467
Alanine aminotransferase increased 137.75 10.51 450 540512 183323 109865014
Neurotoxicity 137.50 10.51 21 540941 42186 110006151
Mental status changes 135.78 10.51 104 540858 76018 109972319
Lupus vulgaris 134.47 10.51 418 540544 33465 110014872
Pulmonary oedema 134.39 10.51 177 540785 100482 109947855
Immunodeficiency 134.18 10.51 457 540505 38381 110009956
Deep vein thrombosis 132.15 10.51 306 540656 139581 109908756
Aspartate aminotransferase increased 131.74 10.51 375 540587 159561 109888776
Cerebral haemorrhage 131.70 10.51 77 540885 64891 109983446
Memory impairment 130.93 10.51 1507 539455 195437 109852900
Orthostatic hypotension 130.81 10.51 81 540881 66168 109982169
Amnesia 130.79 10.51 924 540038 104484 109943853
Serotonin syndrome 130.36 10.51 63 540899 59090 109989247
Syncope 129.38 10.51 530 540432 202006 109846331
Acute myeloid leukaemia 128.74 10.51 17 540945 38093 110010244
Melaena 127.74 10.51 90 540872 68667 109979670
Hypercalcaemia 127.64 10.51 35 540927 46622 110001715
Nausea 127.13 10.51 4854 536108 1230836 108817501
Drug abuse 127.11 10.51 443 540519 176968 109871369
Epilepsy 127.01 10.51 883 540079 99326 109949011
Lung disorder 126.62 10.51 1393 539569 178654 109869683
Ear pain 126.28 10.51 556 540406 52670 109995667
Arthralgia 126.22 10.51 4832 536130 774800 109273537
Upper gastrointestinal haemorrhage 125.53 10.51 44 540918 50052 109998285
Cerebral infarction 124.06 10.51 49 540913 51789 109996548
Cellulitis 123.65 10.51 270 540692 125746 109922591
Hepatotoxicity 123.14 10.51 79 540883 63321 109985016
Back injury 122.38 10.51 508 540454 46891 110001446
Altered state of consciousness 121.57 10.51 65 540897 57561 109990776
Lip swelling 121.52 10.51 531 540431 50136 109998201
Neoplasm progression 120.74 10.51 84 540878 64511 109983826
Pregnancy 120.06 10.51 532 540430 50535 109997802
Anosmia 119.38 10.51 217 540745 12255 110036082
Transaminases increased 119.06 10.51 82 540880 63308 109985029
Skin ulcer 118.65 10.51 83 540879 63562 109984775
Seizure 118.61 10.51 617 540345 220568 109827769
Angioedema 117.89 10.51 856 540106 97644 109950693
Facial pain 117.62 10.51 243 540719 15096 110033241
Respiratory arrest 115.50 10.51 71 540891 58228 109990109
Chronic kidney disease 114.84 10.51 122 540840 76169 109972168
Agranulocytosis 114.53 10.51 81 540881 61679 109986658
Constipation 114.22 10.51 1158 539804 356628 109691709
Prostate cancer 113.31 10.51 23 540939 37618 110010719
Onychomycosis 113.20 10.51 430 540532 38101 110010236
Immunisation 112.90 10.51 106 540856 3077 110045260
Thrombotic microangiopathy 111.56 10.51 8 540954 29141 110019196
Respiratory disorder 111.38 10.51 663 540299 70719 109977618
Hyperglycaemia 111.18 10.51 152 540810 84938 109963399
Nephropathy toxic 109.77 10.51 6 540956 27472 110020865
Laryngitis 109.07 10.51 454 540508 41957 110006380
Sedation 107.64 10.51 109 540853 69574 109978763
Maternal exposure timing unspecified 107.45 10.51 284 540678 20729 110027608
Loss of consciousness 106.72 10.51 545 540417 195761 109852576
Pneumocystis jirovecii pneumonia 106.28 10.51 38 540924 42697 110005640
Product quality issue 106.26 10.51 695 540267 76604 109971733
Diabetes mellitus 105.93 10.51 203 540759 99178 109949159
Ventricular fibrillation 105.75 10.51 35 540927 41278 110007059
Shock haemorrhagic 105.67 10.51 7 540955 27240 110021097
Tension headache 104.59 10.51 177 540785 9441 110038896
Renal tubular necrosis 104.38 10.51 13 540949 30462 110017875
Liver function test abnormal 104.08 10.51 110 540852 68840 109979497
Tremor 104.06 10.51 572 540390 201660 109846677
Electrocardiogram QT prolonged 104.00 10.51 237 540725 108723 109939614
Psychotic disorder 103.77 10.51 60 540902 50877 109997460
Acute respiratory distress syndrome 103.72 10.51 66 540896 53132 109995205
Exostosis 103.71 10.51 473 540489 45483 110002854
Headache 102.67 10.51 5287 535675 877090 109171247
Epistaxis 102.06 10.51 313 540649 130059 109918278
Product label confusion 101.58 10.51 292 540670 22385 110025952
Osteonecrosis of jaw 101.53 10.51 54 540908 47963 110000374
Lupus-like syndrome 101.27 10.51 432 540530 40360 110007977
Anti-cyclic citrullinated peptide antibody 101.25 10.51 269 540693 19695 110028642
Blood lactate dehydrogenase increased 101.13 10.51 45 540917 44289 110004048
Arrhythmia 100.61 10.51 115 540847 69460 109978877
Atrial tachycardia 99.93 10.51 169 540793 9009 110039328
Pericardial effusion 98.49 10.51 81 540881 57136 109991201
Bacteraemia 98.32 10.51 42 540920 42348 110005989
Ear infection 98.10 10.51 583 540379 62149 109986188
Neuroleptic malignant syndrome 98.08 10.51 23 540939 34036 110014301
Peritonitis 97.99 10.51 20 540942 32587 110015750
Coronary artery disease 97.82 10.51 124 540838 71566 109976771
Victim of chemical submission 97.21 10.51 58 540904 821 110047516
Unresponsive to stimuli 96.03 10.51 102 540860 63688 109984649
Premature delivery 95.86 10.51 17 540945 30615 110017722
Adverse drug reaction 95.69 10.51 861 540101 104698 109943639
Leukocytosis 95.42 10.51 74 540888 53754 109994583
Posterior reversible encephalopathy syndrome 95.29 10.51 24 540938 33837 110014500
Labelled drug-drug interaction medication error 94.49 10.51 15 540947 29287 110019050
Proteinuria 93.86 10.51 39 540923 39979 110008358
Hypothyroidism 93.46 10.51 132 540830 72767 109975570
Angina pectoris 93.34 10.51 100 540862 62195 109986142
Plasma cell myeloma 93.22 10.51 102 540860 62834 109985503
Drug ineffective for unapproved indication 92.34 10.51 231 540731 102607 109945730
Hepatic cytolysis 92.23 10.51 80 540882 54973 109993364
Musculoskeletal pain 91.47 10.51 1329 539633 181694 109866643
Palmar-plantar erythrodysaesthesia syndrome 91.46 10.51 43 540919 40982 110007355
Finger deformity 91.26 10.51 362 540600 32730 110015607
Mucosal inflammation 91.04 10.51 210 540752 95931 109952406
Drug level increased 90.59 10.51 61 540901 47658 110000679
Basal cell carcinoma 89.86 10.51 55 540907 45215 110003122
Carotid artery occlusion 89.75 10.51 165 540797 9400 110038937
Haematemesis 89.55 10.51 94 540868 59014 109989323
Blood pressure decreased 88.89 10.51 278 540684 114813 109933524
Crystal urine present 88.40 10.51 75 540887 1899 110046438
Herpes zoster 87.86 10.51 256 540706 108123 109940214
Inappropriate antidiuretic hormone secretion 87.84 10.51 28 540934 33823 110014514
Cholestasis 87.61 10.51 112 540850 64406 109983931
Tubulointerstitial nephritis 86.05 10.51 83 540879 54201 109994136
Myelodysplastic syndrome 85.57 10.51 38 540924 37446 110010891
Haematochezia 85.09 10.51 285 540677 115239 109933098
Suicide attempt 84.71 10.51 243 540719 103151 109945186
Bone erosion 82.42 10.51 446 540516 45925 110002412
Ileus 82.30 10.51 24 540938 30705 110017632
Extrapyramidal disorder 82.13 10.51 20 540942 28847 110019490
Electric shock 80.94 10.51 69 540893 1759 110046578
Transplant rejection 80.54 10.51 12 540950 24555 110023782
Cataract 79.88 10.51 168 540794 79317 109969020
Gamma-glutamyltransferase increased 79.61 10.51 110 540852 61199 109987138
Status epilepticus 78.64 10.51 28 540934 31543 110016794
Dry skin 77.54 10.51 837 540125 106816 109941521
Metastases to central nervous system 77.50 10.51 10 540952 22807 110025530
Pancreatitis acute 77.41 10.51 109 540853 60165 109988172
Haematotoxicity 77.30 10.51 7 540955 21075 110027262
Bacterial infection 76.99 10.51 67 540895 45969 110002368
Coagulopathy 76.72 10.51 53 540909 40858 110007479
Chronic obstructive pulmonary disease 76.55 10.51 275 540687 108883 109939454
Cardiomyopathy 76.51 10.51 34 540928 33491 110014846
Cytomegalovirus infection reactivation 76.49 10.51 3 540959 18330 110030007
Rheumatoid nodule 76.45 10.51 6 540956 20290 110028047
Confusional state 76.17 10.51 2907 538055 465773 109582564
General physical health deterioration 75.94 10.51 2666 538296 422629 109625708
Sleep disorder due to a general medical condition 75.60 10.51 475 540487 51637 109996700
Liver disorder 75.52 10.51 1044 539918 141199 109907138
Pain of skin 74.82 10.51 242 540720 19787 110028550
Cytopenia 74.52 10.51 27 540935 30089 110018248
Blood pressure fluctuation 74.48 10.51 159 540803 74665 109973672
Foot deformity 74.17 10.51 448 540514 48032 110000305
Ischaemic stroke 74.06 10.51 56 540906 41207 110007130
Acute respiratory failure 74.03 10.51 161 540801 75099 109973238
Respiratory distress 74.00 10.51 140 540822 68734 109979603
Myalgia 73.74 10.51 713 540249 221668 109826669
Seronegative arthritis 73.48 10.51 184 540778 12993 110035344
Dysarthria 73.17 10.51 192 540770 83929 109964408
Metastases to liver 73.06 10.51 41 540921 35345 110012992
Blood pressure increased 72.15 10.51 862 540100 257511 109790826
Electrolyte imbalance 72.10 10.51 46 540916 36982 110011355
Hypophagia 71.82 10.51 91 540871 52535 109995802
Femur fracture 71.65 10.51 67 540895 44402 110003935
Metastases to bone 71.31 10.51 32 540930 31340 110016997
Hypocalcaemia 71.00 10.51 132 540830 65234 109983103
Haematoma 70.95 10.51 110 540852 58366 109989971
Creatinine renal clearance decreased 70.73 10.51 11 540951 21804 110026533
Haemoptysis 70.72 10.51 152 540810 71202 109977135
Diabetic ketoacidosis 70.59 10.51 61 540901 41997 110006340
Acute hepatic failure 70.06 10.51 46 540916 36422 110011915
Pulmonary hypertension 69.79 10.51 101 540861 55119 109993218
Agitation 69.59 10.51 300 540662 112751 109935586
Left ventricular dysfunction 69.39 10.51 15 540947 23478 110024859
Haemophagocytic lymphohistiocytosis 68.95 10.51 34 540928 31525 110016812
Oedema 68.83 10.51 1425 539537 208551 109839786
Activated partial thromboplastin time prolonged 68.73 10.51 13 540949 22355 110025982
Dyspepsia 68.28 10.51 1313 539649 189652 109858685
Cardiac failure acute 67.89 10.51 17 540945 24061 110024276
Pneumonitis 67.86 10.51 173 540789 76358 109971979
Product prescribing error 67.76 10.51 91 540871 51240 109997097
Walking aid user 67.30 10.51 272 540690 24803 110023534
Clostridium difficile colitis 67.02 10.51 69 540893 43709 110004628
Therapy partial responder 66.90 10.51 50 540912 37011 110011326
Localised infection 66.87 10.51 67 540895 42981 110005356
Osteomyelitis 66.56 10.51 49 540913 36551 110011786
Subdural haematoma 66.04 10.51 49 540913 36405 110011932
Pulmonary alveolar haemorrhage 65.69 10.51 10 540952 20140 110028197
Myoclonus 65.62 10.51 40 540922 32958 110015379
Lethargy 65.44 10.51 236 540726 93340 109954997
Ejection fraction decreased 65.38 10.51 62 540900 40818 110007519
Hypervolaemia 64.96 10.51 88 540874 49372 109998965
Gastric ulcer 64.17 10.51 60 540902 39767 110008570
Hemiparesis 64.09 10.51 72 540890 43831 110004506
Gangrene 63.96 10.51 4 540958 16337 110032000
Injection site reaction 63.90 10.51 692 540270 88378 109959959
Oliguria 63.80 10.51 8 540954 18649 110029688
Hypomagnesaemia 63.74 10.51 124 540838 60246 109988091
Troponin increased 63.63 10.51 33 540929 29733 110018604
White blood cells urine positive 63.43 10.51 124 540838 7400 110040937
Anuria 63.40 10.51 20 540942 24321 110024016
Oxygen saturation decreased 63.38 10.51 478 540484 156504 109891833
Overdose 63.00 10.51 786 540176 233008 109815329
Oral allergy syndrome 62.88 10.51 22 540940 75 110048262
Cystitis 62.71 10.51 144 540818 65892 109982445
Hepatic encephalopathy 62.40 10.51 30 540932 28226 110020111
Urinary sediment present 61.99 10.51 69 540893 2459 110045878
Generalised tonic-clonic seizure 61.55 10.51 108 540854 54572 109993765
Skin necrosis 61.02 10.51 15 540947 21497 110026840
Anticipatory anxiety 60.97 10.51 50 540912 1206 110047131
Treatment noncompliance 60.19 10.51 171 540791 72819 109975518
Blood calcium decreased 60.15 10.51 52 540910 35793 110012544
Metastases to lung 59.98 10.51 19 540943 23044 110025293
Cytomegalovirus viraemia 59.82 10.51 8 540954 17756 110030581
Graft versus host disease 59.81 10.51 10 540952 18796 110029541
Neoplasm malignant 59.80 10.51 56 540906 37087 110011250
Heart rate decreased 59.69 10.51 206 540756 82550 109965787
Renal injury 59.40 10.51 10 540952 18703 110029634
Haemodynamic instability 59.27 10.51 19 540943 22869 110025468
Haemorrhage intracranial 59.19 10.51 34 540928 28935 110019402
Intestinal obstruction 59.13 10.51 106 540856 53121 109995216
Circulatory collapse 59.03 10.51 74 540888 42919 110005418
Hip fracture 58.98 10.51 51 540911 35100 110013237
Joint dislocation 58.85 10.51 326 540636 33864 110014473
Hemiplegia 58.84 10.51 19 540943 22763 110025574
Drug hypersensitivity 58.72 10.51 2750 538212 451340 109596997
Eczema 58.68 10.51 576 540386 71717 109976620
Klebsiella infection 58.64 10.51 13 540949 19996 110028341
Aspergillus infection 58.42 10.51 26 540936 25590 110022747
Renal disorder 58.21 10.51 95 540867 49384 109998953
Tachypnoea 58.18 10.51 64 540898 39331 110009006
Respiratory depression 57.99 10.51 43 540919 31958 110016379
Toxic epidermal necrolysis 57.76 10.51 119 540843 56608 109991729
Tumour lysis syndrome 57.63 10.51 40 540922 30761 110017576
Chronic sinusitis 57.21 10.51 259 540703 24825 110023512
Pathogen resistance 57.09 10.51 9 540953 17663 110030674
Hypophosphataemia 57.08 10.51 47 540915 33135 110015202
Oedema peripheral 56.87 10.51 1200 539762 327460 109720877
Hallucination, auditory 56.82 10.51 29 540933 26368 110021969
Breast cancer stage II 56.82 10.51 275 540687 27100 110021237
Arteriosclerosis 56.71 10.51 25 540937 24742 110023595
Infusion site reaction 56.69 10.51 203 540759 17479 110030858
Dyspnoea exertional 56.48 10.51 289 540673 103771 109944566
Myocarditis 56.28 10.51 39 540923 30016 110018321
Urticaria chronic 56.02 10.51 39 540923 729 110047608
Stress cardiomyopathy 55.99 10.51 6 540956 15800 110032537
Cardiotoxicity 55.91 10.51 8 540954 16873 110031464
Pneumothorax 55.87 10.51 54 540908 35231 110013106
Haemoglobin urine present 55.82 10.51 42 540920 890 110047447
Candida infection 55.71 10.51 93 540869 47916 110000421
Porphyria acute 55.50 10.51 210 540752 18570 110029767
Immune reconstitution inflammatory syndrome 55.38 10.51 7 540955 16219 110032118
Chronic spontaneous urticaria 55.18 10.51 58 540904 1935 110046402
Panniculitis 54.98 10.51 6 540956 15576 110032761
Balance disorder 54.96 10.51 339 540623 116221 109932116
Cardiac disorder 54.93 10.51 190 540772 76090 109972247
Diverticulitis 54.73 10.51 112 540850 53410 109994927
Weight decreased 53.66 10.51 1813 539149 466244 109582093
Blood phosphorus increased 53.52 10.51 8 540954 16332 110032005
Hallucination, visual 53.51 10.51 69 540893 39536 110008801
Escherichia infection 53.03 10.51 25 540937 23791 110024546
Therapy cessation 52.89 10.51 86 540876 44771 110003566
Hepatic steatosis 52.69 10.51 99 540863 48732 109999605
Second primary malignancy 52.43 10.51 12 540950 18056 110030281
Paraesthesia 52.23 10.51 1745 539217 274776 109773561
Fracture 52.22 10.51 28 540934 24760 110023577
Adverse reaction 52.16 10.51 284 540678 29310 110019027
Pallor 52.13 10.51 125 540837 56342 109991995
Blood parathyroid hormone decreased 51.85 10.51 3 540959 13086 110035251
Diffuse large B-cell lymphoma 51.58 10.51 8 540954 15890 110032447
Staphylococcal infection 51.19 10.51 173 540789 69771 109978566
Aphasia 51.05 10.51 135 540827 58862 109989475
Intestinal ischaemia 50.58 10.51 9 540953 16170 110032167
Bladder cancer 50.53 10.51 18 540944 20274 110028063
Cholelithiasis 50.53 10.51 151 540811 63271 109985066
Akathisia 50.39 10.51 11 540951 17102 110031235
Lymphocyte percentage decreased 50.33 10.51 92 540870 5218 110043119
Rash erythematous 50.30 10.51 617 540345 81215 109967122
End stage renal disease 50.24 10.51 21 540941 21452 110026885
Urinary retention 49.89 10.51 174 540788 69509 109978828
Hyperbilirubinaemia 49.66 10.51 46 540916 30625 110017712
Foetal death 49.57 10.51 182 540780 15863 110032474
Drug ineffective 49.49 10.51 6602 534360 1513938 108534399
Muscle rigidity 49.39 10.51 28 540934 24003 110024334
Pulmonary toxicity 49.13 10.51 13 540949 17733 110030604
Colitis 49.08 10.51 296 540666 102027 109946310
Haemodialysis 49.02 10.51 13 540949 17706 110030631
Dysphagia 49.01 10.51 497 540465 153103 109895234
Arterial occlusive disease 48.99 10.51 8 540954 15300 110033037
Lung neoplasm malignant 48.86 10.51 56 540906 33786 110014551
Drug level decreased 48.74 10.51 15 540947 18533 110029804
Depression 48.61 10.51 1956 539006 315379 109732958
Enterocolitis 48.59 10.51 16 540946 18933 110029404
Osteonecrosis 48.53 10.51 56 540906 33685 110014652
Urine leukocyte esterase positive 48.42 10.51 75 540887 3711 110044626
Encephalitis 48.15 10.51 16 540946 18823 110029514
Hypertensive crisis 47.83 10.51 30 540932 24342 110023995
Hypertension 47.81 10.51 2998 537964 507086 109541251
Prescribed underdose 47.52 10.51 508 540454 64666 109983671
Blood urea increased 47.37 10.51 126 540836 54831 109993506
Blood potassium increased 46.95 10.51 56 540906 33193 110015144
Blood alkaline phosphatase increased 46.93 10.51 183 540779 70752 109977585
Appendicitis 46.91 10.51 42 540920 28422 110019915
Clostridium difficile infection 46.86 10.51 117 540845 52012 109996325
Neuralgia 46.61 10.51 105 540857 48373 109999964
Oesophagitis 46.57 10.51 43 540919 28672 110019665
Mastocytosis 46.55 10.51 36 540926 796 110047541
Chills 46.48 10.51 654 540308 189926 109858411
Toxic encephalopathy 46.41 10.51 9 540953 15205 110033132
Drug eruption 46.27 10.51 123 540839 53536 109994801
Dialysis 46.20 10.51 19 540943 19600 110028737
Polyneuropathy 46.18 10.51 53 540909 31959 110016378
Febrile bone marrow aplasia 46.12 10.51 14 540948 17451 110030886
Epstein-Barr virus infection 46.02 10.51 17 540945 18721 110029616
Infective pulmonary exacerbation of cystic fibrosis 46.02 10.51 168 540794 14603 110033734
Dyskinesia 45.83 10.51 116 540846 51330 109997007
Duodenal ulcer 45.79 10.51 19 540943 19495 110028842
Urine abnormality 45.56 10.51 122 540840 8974 110039363
Hydronephrosis 45.54 10.51 22 540940 20643 110027694
Pneumonia bacterial 45.41 10.51 37 540925 26224 110022113
Parkinsonism 45.39 10.51 26 540936 22161 110026176
Hyperphosphataemia 45.35 10.51 12 540950 16369 110031968
Gastric haemorrhage 45.33 10.51 11 540951 15904 110032433
Motor dysfunction 45.26 10.51 32 540930 24374 110023963
Pulmonary fibrosis 45.19 10.51 726 540236 101316 109947021
Throat irritation 45.09 10.51 430 540532 53122 109995215
Bronchopulmonary aspergillosis 44.67 10.51 48 540914 29815 110018522
Therapy interrupted 44.65 10.51 112 540850 49710 109998627
Drug reaction with eosinophilia and systemic symptoms 44.55 10.51 228 540734 81867 109966470
Enterococcal infection 44.40 10.51 22 540940 20344 110027993
Enteritis 44.39 10.51 19 540943 19137 110029200
Brain oedema 44.31 10.51 52 540910 31046 110017291
Torsade de pointes 44.11 10.51 28 540934 22572 110025765
Neutrophil percentage increased 43.91 10.51 83 540879 4830 110043507
Acidosis 43.85 10.51 28 540934 22503 110025834
Nephrolithiasis 43.68 10.51 171 540791 66041 109982296
Unevaluable event 43.68 10.51 146 540816 59081 109989256
Intestinal perforation 43.62 10.51 24 540938 20920 110027417
Catatonia 43.54 10.51 3 540959 11297 110037040
Granuloma skin 43.46 10.51 3 540959 11280 110037057
Deafness 43.31 10.51 40 540922 26669 110021668
Drug withdrawal syndrome 42.98 10.51 75 540887 37979 110010358
Malnutrition 42.90 10.51 42 540920 27237 110021100
Device related infection 42.74 10.51 80 540882 39439 110008898
Blood pressure systolic increased 42.52 10.51 235 540727 82756 109965581
Cardiac failure chronic 42.49 10.51 8 540954 13803 110034534
Blood immunoglobulin E increased 42.27 10.51 105 540857 7377 110040960
Paraesthesia oral 42.24 10.51 296 540666 33375 110014962
Tuberculosis 42.20 10.51 17 540945 17757 110030580
Ataxia 42.20 10.51 51 540911 30057 110018280
Mitral valve incompetence 42.08 10.51 61 540901 33268 110015069
Bronchiectasis 42.06 10.51 71 540891 36422 110011915
Dysstasia 42.01 10.51 60 540902 32926 110015411
Generalised oedema 42.00 10.51 53 540909 30651 110017686
Perfume sensitivity 41.93 10.51 38 540924 1053 110047284
Hyperthyroidism 41.62 10.51 49 540913 29212 110019125
Peripheral sensory neuropathy 41.19 10.51 15 540947 16665 110031672
Faecaloma 41.12 10.51 11 540951 14897 110033440
Faeces discoloured 41.05 10.51 64 540898 33884 110014453
Sedation complication 41.00 10.51 23 540939 19832 110028505
Acute graft versus host disease in skin 40.95 10.51 3 540959 10737 110037600
Upper respiratory tract infection 40.66 10.51 884 540078 130444 109917893
Muscle spasms 40.64 10.51 1706 539256 276451 109771886
Muscle spasticity 40.62 10.51 308 540654 35607 110012730
Pulmonary pain 40.61 10.51 93 540869 6200 110042137
Pneumonia fungal 40.48 10.51 11 540951 14743 110033594
Urine analysis abnormal 40.24 10.51 98 540864 6799 110041538
Asthenia 40.17 10.51 2865 538097 686134 109362203
Wrong technique in product usage process 40.17 10.51 256 540706 87092 109961245
Lymphadenopathy 40.14 10.51 168 540794 63667 109984670
Hepatic cancer 40.12 10.51 4 540958 11152 110037185
Oral pruritus 40.01 10.51 64 540898 3256 110045081
Joint destruction 39.78 10.51 131 540831 10812 110037525
Mast cell activation syndrome 39.71 10.51 43 540919 1485 110046852
Euglycaemic diabetic ketoacidosis 39.70 10.51 5 540957 11618 110036719
Right ventricular failure 39.62 10.51 41 540921 25913 110022424
Cardiovascular disorder 39.44 10.51 32 540930 22728 110025609
Red blood cell count decreased 39.32 10.51 177 540785 65746 109982591
Oesophageal carcinoma 39.26 10.51 5 540957 11519 110036818
Influenza like illness 39.19 10.51 262 540700 88150 109960187
Arteriosclerosis coronary artery 39.12 10.51 39 540923 25079 110023258
Pulmonary mass 39.04 10.51 77 540885 37224 110011113
Cachexia 39.03 10.51 8 540954 12997 110035340
Anaphylactic reaction 38.85 10.51 780 540182 113520 109934817
Heparin-induced thrombocytopenia 38.82 10.51 5 540957 11419 110036918
Accidental overdose 38.76 10.51 127 540835 51707 109996630
Myocardial ischaemia 38.69 10.51 44 540918 26640 110021697
Pulmonary haemorrhage 38.65 10.51 16 540946 16440 110031897
Myopathy 38.59 10.51 39 540923 24921 110023416
Glomerular filtration rate decreased 38.55 10.51 51 540911 28905 110019432
Eating disorder 38.44 10.51 57 540905 30801 110017536
Red blood cells urine positive 38.42 10.51 81 540881 5104 110043233
Skin plaque 37.87 10.51 142 540820 12503 110035834
Impaired work ability 37.83 10.51 44 540918 26375 110021962
Immunosuppressant drug level increased 37.81 10.51 6 540956 11718 110036619
COVID-19 pneumonia 37.74 10.51 78 540884 37065 110011272
Rheumatoid arthritis 37.52 10.51 1809 539153 297804 109750533
Systemic candida 37.42 10.51 3 540959 9971 110038366
Full blood count decreased 37.41 10.51 62 540900 32037 110016300
Atelectasis 37.39 10.51 77 540885 36635 110011702
Haematocrit decreased 37.38 10.51 181 540781 65936 109982401
Lower gastrointestinal haemorrhage 37.33 10.51 22 540940 18464 110029873
Normochromic normocytic anaemia 37.24 10.51 9 540953 13048 110035289
Mixed liver injury 37.16 10.51 7 540955 12072 110036265
Neurological symptom 36.94 10.51 15 540947 15593 110032744
Restrictive pulmonary disease 36.80 10.51 61 540901 3198 110045139
Abdominal pain 36.79 10.51 2093 538869 510896 109537441
Kidney transplant rejection 36.76 10.51 7 540955 11980 110036357
Parathyroid gland enlargement 36.63 10.51 19 540943 201 110048136
Scratch 36.61 10.51 143 540819 12836 110035501
Hypoalbuminaemia 36.61 10.51 53 540909 28921 110019416
Blood albumin decreased 36.52 10.51 49 540913 27603 110020734
Pain in jaw 36.49 10.51 128 540834 51049 109997288
Benign prostatic hyperplasia 36.40 10.51 22 540940 18212 110030125
Temperature intolerance 36.39 10.51 150 540812 13800 110034537
Hypernatraemia 36.33 10.51 21 540941 17812 110030525
Metastases to lymph nodes 36.31 10.51 14 540948 15018 110033319
Personality disorder 36.31 10.51 9 540953 12828 110035509
Swollen joint count 36.28 10.51 109 540853 8565 110039772
Neutropenic sepsis 36.20 10.51 59 540903 30687 110017650
Renal cyst 36.18 10.51 22 540940 18150 110030187
Diabetes mellitus inadequate control 36.13 10.51 56 540906 29719 110018618
Ulcer haemorrhage 36.08 10.51 211 540751 22360 110025977
Neck pain 35.97 10.51 822 540140 122308 109926029
Rib fracture 35.96 10.51 69 540893 33701 110014636
Splenomegaly 35.95 10.51 40 540922 24458 110023879
Skin toxicity 35.88 10.51 7 540955 11776 110036561
Gastroenteritis 35.73 10.51 86 540876 38714 110009623
Pancreatic carcinoma 35.68 10.51 14 540948 14858 110033479
Dysgeusia 35.40 10.51 199 540763 69786 109978551
Red blood cell sedimentation rate increased 35.38 10.51 559 540403 77743 109970594
Ventricular arrhythmia 35.29 10.51 4 540958 10083 110038254
Nephropathy 35.19 10.51 11 540951 13456 110034881
Head deformity 35.03 10.51 14 540948 75 110048262
Eye swelling 34.93 10.51 279 540683 32769 110015568
Visual acuity reduced 34.91 10.51 65 540897 32108 110016229
Monocyte chemotactic protein-1 increased 34.87 10.51 22 540940 346 110047991
Abdominal pain lower 34.84 10.51 82 540880 37201 110011136
Enthesopathy 34.81 10.51 9 540953 12469 110035868
Acute coronary syndrome 34.73 10.51 37 540925 23075 110025262
Lymphopenia 34.69 10.51 92 540870 40078 110008259
Post-traumatic stress disorder 34.59 10.51 90 540872 6506 110041831
Spinal compression fracture 34.26 10.51 24 540938 18368 110029969
Fistula 34.16 10.51 16 540946 15283 110033054
Iron deficiency anaemia 34.03 10.51 64 540898 31495 110016842
Disease recurrence 34.01 10.51 167 540795 60617 109987720
Granulocytopenia 33.92 10.51 10 540952 12705 110035632
Schizophrenia 33.87 10.51 34 540928 21792 110026545
Atrioventricular block complete 33.86 10.51 29 540933 20053 110028284
Cardiac tamponade 33.84 10.51 7 540955 11300 110037037
Blood pressure diastolic abnormal 33.83 10.51 46 540916 25769 110022568
Hypomania 33.44 10.51 5 540957 10205 110038132
Vomiting 33.34 10.51 3923 537039 906752 109141585
Device difficult to use 33.14 10.51 26 540936 18779 110029558
Amyloid arthropathy 33.12 10.51 41 540921 1639 110046698
Blood calcium increased 33.00 10.51 24 540938 18016 110030321
Lymphoma 32.96 10.51 30 540932 20141 110028196
Gout 32.92 10.51 82 540880 36484 110011853
Pleuritic pain 32.89 10.51 19 540943 16121 110032216
Sopor 32.87 10.51 82 540880 36464 110011873
Blood pressure systolic abnormal 32.85 10.51 44 540918 24806 110023531
Prothrombin time prolonged 32.85 10.51 22 540940 17239 110031098
Nail operation 32.85 10.51 41 540921 1653 110046684
Gastrooesophageal reflux disease 32.76 10.51 1131 539831 178845 109869492
Liver function test increased 32.72 10.51 612 540350 87936 109960401
Alpha tumour necrosis factor increased 32.60 10.51 22 540940 390 110047947
Hyperlipidaemia 32.58 10.51 80 540882 35768 110012569
Gastric cancer 32.57 10.51 7 540955 11001 110037336
Body temperature increased 32.53 10.51 410 540552 54303 109994034
Supraventricular tachycardia 32.53 10.51 43 540919 24379 110023958
Metabolic disorder 32.52 10.51 6 540956 10504 110037833
Diarrhoea haemorrhagic 32.46 10.51 18 540944 15621 110032716
Blood potassium decreased 32.45 10.51 145 540817 53969 109994368
Restlessness 32.39 10.51 153 540809 56106 109992231
Hypothermia 32.36 10.51 49 540913 26253 110022084
Dysuria 32.27 10.51 168 540794 60063 109988274
Cholangitis 32.21 10.51 20 540942 16315 110032022
Iron deficiency 31.99 10.51 26 540936 18450 110029887
Urticaria thermal 31.96 10.51 24 540938 507 110047830
Mouth ulceration 31.96 10.51 124 540838 48014 110000323
Large intestine perforation 31.91 10.51 21 540941 16608 110031729
Hepatic cirrhosis 31.78 10.51 486 540476 67140 109981197
Pulse absent 31.78 10.51 8 540954 11284 110037053
Flatulence 31.71 10.51 139 540823 52010 109996327
Blood lactic acid increased 31.71 10.51 19 540943 15802 110032535
Victim of sexual abuse 31.64 10.51 24 540938 515 110047822
Disorientation 31.54 10.51 209 540753 70462 109977875
Anxiety 31.53 10.51 2024 538938 343054 109705283
Drug level below therapeutic 31.47 10.51 9 540953 11664 110036673
Hypogammaglobulinaemia 31.46 10.51 31 540931 20045 110028292
Post cholecystectomy syndrome 31.43 10.51 29 540933 823 110047514
Respiratory tract infection 31.36 10.51 213 540749 71404 109976933
Affect lability 31.32 10.51 27 540935 18610 110029727
Type I hypersensitivity 31.27 10.51 85 540877 6308 110042029
Sinus tachycardia 31.25 10.51 112 540850 44381 110003956
Spondylitis 31.24 10.51 124 540838 11214 110037123
Lung infiltration 31.16 10.51 45 540917 24583 110023754
Skin laceration 30.93 10.51 75 540887 33678 110014659
Haemolytic anaemia 30.87 10.51 34 540928 20886 110027451
Acute pulmonary oedema 30.59 10.51 23 540939 16973 110031364
Bundle branch block right 30.44 10.51 11 540951 12280 110036057
Visual impairment 30.33 10.51 867 540095 133561 109914776
Hypertriglyceridaemia 30.19 10.51 21 540941 16133 110032204
Aortic stenosis 30.19 10.51 13 540949 13046 110035291
Hepatocellular injury 30.18 10.51 136 540826 50506 109997831
Malaise 30.16 10.51 3740 537222 668079 109380258
Renal cancer 30.09 10.51 13 540949 13021 110035316
Hypovolaemia 30.08 10.51 37 540925 21637 110026700
Feeling hot 30.06 10.51 619 540343 90487 109957850
Hypovolaemic shock 29.96 10.51 17 540945 14566 110033771
Ileus paralytic 29.94 10.51 10 540952 11727 110036610
Pulseless electrical activity 29.74 10.51 23 540939 16734 110031603
Vaginal flatulence 29.67 10.51 128 540834 12016 110036321
Urine output decreased 29.67 10.51 32 540930 19844 110028493
Tachyarrhythmia 29.61 10.51 3 540959 8258 110040079
Alanine aminotransferase abnormal 29.60 10.51 5 540957 9329 110039008
Lung opacity 29.60 10.51 10 540952 11642 110036695
Squamous cell carcinoma 29.53 10.51 28 540934 18435 110029902
Neonatal hypoacusis 29.46 10.51 9 540953 17 110048320
Escherichia sepsis 29.45 10.51 7 540955 10265 110038072
Grip strength 29.35 10.51 105 540857 9036 110039301
Gastrointestinal toxicity 29.32 10.51 9 540953 11139 110037198
Nystagmus 29.29 10.51 10 540952 11567 110036770
Inappropriate schedule of product administration 29.22 10.51 765 540197 202872 109845465
Device malfunction 29.20 10.51 50 540912 25508 110022829
Small intestinal obstruction 29.19 10.51 72 540890 32141 110016196
Tricuspid valve incompetence 28.87 10.51 45 540917 23828 110024509
Pulmonary tuberculosis 28.75 10.51 5 540957 9134 110039203
Vocal cord dysfunction 28.75 10.51 29 540933 921 110047416
Pseudomonas infection 28.72 10.51 58 540904 27795 110020542
Organising pneumonia 28.69 10.51 17 540945 14226 110034111
Adenovirus infection 28.69 10.51 9 540953 10985 110037352
Ketoacidosis 28.67 10.51 7 540955 10080 110038257
Nephrotic syndrome 28.59 10.51 16 540946 13815 110034522
Systemic inflammatory response syndrome 28.57 10.51 14 540948 13029 110035308
Rash maculo-papular 28.55 10.51 229 540733 73993 109974344
Delusion 28.52 10.51 45 540917 23710 110024627
Auditory neuropathy spectrum disorder 28.49 10.51 9 540953 20 110048317
Electrocardiogram QRS complex prolonged 28.49 10.51 14 540948 13007 110035330
Seasonal allergy 28.12 10.51 179 540783 19543 110028794
Suspected suicide 28.09 10.51 20 540942 15179 110033158
Tenosynovitis 28.08 10.51 23 540939 16260 110032077
Blood sodium decreased 27.89 10.51 95 540867 38224 110010113
Adjustment disorder 27.88 10.51 9 540953 10786 110037551
Mechanical urticaria 27.87 10.51 23 540939 560 110047777
Poisoning deliberate 27.87 10.51 54 540908 26277 110022060
Unintentional medical device removal 27.82 10.51 5 540957 8918 110039419
Heart rate irregular 27.74 10.51 81 540881 34193 110014144
Drug level above therapeutic 27.65 10.51 11 540951 11577 110036760
Vision blurred 27.60 10.51 454 540508 128568 109919769
Pulmonary congestion 27.45 10.51 70 540892 30896 110017441
Colon cancer 27.41 10.51 24 540938 16419 110031918
Pyelonephritis 27.41 10.51 51 540911 25199 110023138
Cardiac murmur 27.40 10.51 49 540913 24579 110023758
Angina unstable 27.37 10.51 24 540938 16408 110031929
Staphylococcal sepsis 27.30 10.51 27 540935 17427 110030910
Hyperlactacidaemia 27.27 10.51 4 540958 8282 110040055
Body temperature decreased 27.27 10.51 91 540871 36844 110011493
Salivary hypersecretion 27.19 10.51 27 540935 17394 110030943
Muscle twitching 27.03 10.51 244 540718 29691 110018646
Speech disorder 27.02 10.51 183 540779 61386 109986951
Electrocardiogram abnormal 26.96 10.51 31 540931 18678 110029659
Necrosis 26.93 10.51 11 540951 11395 110036942
Endophthalmitis 26.83 10.51 4 540958 8183 110040154
Osteopenia 26.73 10.51 42 540920 22167 110026170
Disability 26.61 10.51 245 540717 29978 110018359
Blood uric acid increased 26.59 10.51 40 540922 21489 110026848
Decubitus ulcer 26.52 10.51 30 540932 18206 110030131
Sensory loss 26.38 10.51 40 540922 21417 110026920
Hepatitis fulminant 26.25 10.51 5 540957 8555 110039782
Anal abscess 26.25 10.51 12 540950 11626 110036711
Failure to thrive 26.24 10.51 17 540945 13557 110034780
Uveitis 26.18 10.51 41 540921 21669 110026668
Spinal fracture 26.12 10.51 44 540918 22589 110025748
Venous thrombosis 26.01 10.51 5 540957 8500 110039837
Muscular weakness 26.00 10.51 1475 539487 246993 109801344
Jaundice cholestatic 25.99 10.51 20 540942 14588 110033749
Polyuria 25.99 10.51 29 540933 17709 110030628
Nasal turbinate hypertrophy 25.97 10.51 26 540936 818 110047519
Hepatic lesion 25.96 10.51 5 540957 8488 110039849
Urosepsis 25.93 10.51 71 540891 30604 110017733
Tooth disorder 25.93 10.51 67 540895 29442 110018895
Forced expiratory volume 25.90 10.51 12 540950 97 110048240
Staphylococcal bacteraemia 25.89 10.51 26 540936 16662 110031675
Sudden death 25.84 10.51 50 540912 24345 110023992
Drug tolerance 25.84 10.51 154 540808 16431 110031906
Vaginal discharge 25.82 10.51 163 540799 17745 110030592
Ankylosing spondylitis 25.77 10.51 23 540939 15589 110032748
Middle insomnia 25.58 10.51 180 540782 20322 110028015
Bone disorder 25.58 10.51 40 540922 21152 110027185
Ulcer 25.57 10.51 116 540846 43000 110005337
Normal newborn 25.45 10.51 189 540773 21707 110026630
Head injury 25.35 10.51 116 540846 42901 110005436
Femoral neck fracture 25.32 10.51 15 540947 12552 110035785
Bronchial neoplasm 25.32 10.51 21 540941 515 110047822
Spinal pain 25.28 10.51 32 540930 18483 110029854
Escherichia urinary tract infection 25.28 10.51 25 540937 16137 110032200
Blood glucose increased 25.23 10.51 476 540486 132020 109916317
Ankle arthroplasty 25.20 10.51 45 540917 2506 110045831
Partial seizures 25.14 10.51 12 540950 11337 110037000
Peritonitis bacterial 25.13 10.51 10 540952 10523 110037814
Hypoacusis 25.10 10.51 88 540874 35103 110013234
Erythema 25.10 10.51 1701 539261 289746 109758591
Hiccups 25.04 10.51 16 540946 12853 110035484
Cardiomegaly 24.94 10.51 67 540895 29063 110019274
Clostridium test positive 24.93 10.51 11 540951 10882 110037455
Nervous system disorder 24.93 10.51 76 540886 31645 110016692
Lymphoproliferative disorder 24.91 10.51 3 540959 7215 110041122
Poisoning 24.88 10.51 67 540895 29038 110019299
Fungal infection 24.87 10.51 146 540816 50660 109997677
Liver abscess 24.87 10.51 4 540958 7735 110040602
Hereditary angioedema 24.82 10.51 84 540878 7030 110041307
Hyper IgE syndrome 24.77 10.51 23 540939 658 110047679
Atrioventricular block first degree 24.65 10.51 20 540942 14205 110034132
Gastritis erosive 24.63 10.51 14 540948 11986 110036351
Colorectal cancer 24.62 10.51 7 540955 9107 110039230
Intentional self-injury 24.48 10.51 97 540865 37332 110011005
Retinal haemorrhage 24.40 10.51 8 540954 9493 110038844
Hepatitis cholestatic 24.36 10.51 30 540932 17536 110030801
Subarachnoid haemorrhage 24.27 10.51 237 540725 29465 110018872
Squamous cell carcinoma of skin 24.26 10.51 29 540933 17174 110031163
Eosinophilic oesophagitis 24.24 10.51 31 540931 1281 110047056
Cholecystitis 24.12 10.51 57 540905 25825 110022512
Aspiration 24.10 10.51 73 540889 30460 110017877
Haemothorax 24.08 10.51 3 540959 7028 110041309
Immunosuppression 23.93 10.51 31 540931 17728 110030609
Multiple fractures 23.91 10.51 7 540955 8933 110039404
Multiple drug therapy 23.91 10.51 5 540957 8009 110040328
Gastritis 23.87 10.51 159 540803 53540 109994797
Apnoea 23.86 10.51 19 540943 13620 110034717
Mental disorder 23.83 10.51 103 540859 38688 110009649
Immune-mediated enterocolitis 23.76 10.51 10 540952 10175 110038162
Hypopnoea 23.76 10.51 13 540949 11367 110036970
Blood loss anaemia 23.74 10.51 32 540930 17993 110030344
Prostatic specific antigen increased 23.74 10.51 16 540946 12495 110035842
Penis injury 23.71 10.51 12 540950 120 110048217
Autoimmune haemolytic anaemia 23.67 10.51 11 540951 10556 110037781
Gastrointestinal perforation 23.63 10.51 4 540958 7452 110040885
Cerebral ischaemia 23.62 10.51 15 540947 12089 110036248
Brain herniation 23.59 10.51 7 540955 8856 110039481
Urinary incontinence 23.59 10.51 140 540822 48447 109999890
Substance abuse 23.56 10.51 16 540946 12447 110035890
Diastolic dysfunction 23.35 10.51 16 540946 12388 110035949
Atrioventricular block 23.22 10.51 29 540933 16848 110031489
Crepitations 23.18 10.51 12 540950 10823 110037514
Haemorrhagic stroke 23.14 10.51 20 540942 13769 110034568
Intercepted product preparation error 23.14 10.51 3 540959 6817 110041520
Aggression 23.09 10.51 182 540780 59028 109989309
Cystic fibrosis pancreatic 23.02 10.51 9 540953 45 110048292
Subcutaneous drug absorption impaired 22.93 10.51 86 540876 7573 110040764
Abscess 22.90 10.51 64 540898 27405 110020932
Coronary artery occlusion 22.87 10.51 26 540936 15746 110032591
Blood pressure abnormal 22.86 10.51 47 540915 22377 110025960
Upper respiratory fungal infection 22.86 10.51 18 540944 409 110047928
Musculoskeletal disorder 22.69 10.51 48 540914 22616 110025721
Neoplasm 22.67 10.51 13 540949 11074 110037263
Paronychia 22.64 10.51 13 540949 11068 110037269
Pseudomonal sepsis 22.57 10.51 8 540954 9038 110039299
Potassium wasting nephropathy 22.55 10.51 13 540949 172 110048165
Proctitis 22.53 10.51 151 540811 16776 110031561
Influenza 22.51 10.51 642 540320 168459 109879878
Pneumatosis intestinalis 22.23 10.51 7 540955 8522 110039815
Lichen sclerosus 22.22 10.51 28 540934 1140 110047197
Pulmonary arterial hypertension 22.20 10.51 83 540879 32485 110015852
Pollakiuria 22.17 10.51 126 540836 44069 110004268
Neutropenic colitis 22.15 10.51 6 540956 8059 110040278
Product monitoring error 22.09 10.51 8 540954 8919 110039418
Drug effective for unapproved indication 22.06 10.51 22 540940 14145 110034192
Device occlusion 22.06 10.51 25 540937 15160 110033177
Potentiating drug interaction 21.94 10.51 15 540947 11628 110036709
Inflammatory marker increased 21.93 10.51 23 540939 14446 110033891
Autoimmune hepatitis 21.91 10.51 24 540938 14780 110033557
Peripheral arterial occlusive disease 21.83 10.51 9 540953 9271 110039066
Lipase increased 21.82 10.51 36 540926 18636 110029701
Herpes simplex 21.78 10.51 27 540935 15737 110032600
Hepatic enzyme 21.70 10.51 65 540897 5098 110043239
Anal incontinence 21.58 10.51 47 540915 21917 110026420
Hepatitis B 21.54 10.51 10 540952 9602 110038735
Humerus fracture 21.52 10.51 13 540949 10763 110037574
Exposure via body fluid 21.51 10.51 16 540946 333 110048004
Duodenitis 21.50 10.51 9 540953 9187 110039150
Pneumonia cytomegaloviral 21.46 10.51 4 540958 6950 110041387
Fixed eruption 21.44 10.51 57 540905 4175 110044162
Renal tubular disorder 21.42 10.51 5 540957 7424 110040913
Cough 21.42 10.51 1955 539007 459686 109588651
Aplasia pure red cell 21.41 10.51 10 540952 9568 110038769
Sarcoidosis 21.41 10.51 18 540944 12561 110035776
Haemolysis 21.38 10.51 27 540935 15612 110032725
Embolism 21.37 10.51 29 540933 16260 110032077
Breath sounds abnormal 21.32 10.51 59 540903 25345 110022992
Bronchial disorder 21.31 10.51 44 540918 2732 110045605
SARS-CoV-2 test negative 21.29 10.51 38 540924 2115 110046222
Stevens-Johnson syndrome 21.28 10.51 138 540824 46763 110001574
Malignant melanoma 21.24 10.51 31 540931 16860 110031477
Metastasis 21.16 10.51 7 540955 8260 110040077
Aortic aneurysm 21.14 10.51 11 540951 9893 110038444
Varicella zoster virus infection 21.13 10.51 3 540959 6365 110041972
Ammonia increased 21.09 10.51 7 540955 8243 110040094
Full blood count abnormal 21.07 10.51 174 540788 55878 109992459
Vascular device infection 21.06 10.51 30 540932 16482 110031855
Venoocclusive liver disease 21.06 10.51 26 540936 15181 110033156
Intestinal haemorrhage 21.05 10.51 5 540957 7336 110041001
Left ventricular failure 21.03 10.51 15 540947 11374 110036963
Cestode infection 20.98 10.51 15 540947 293 110048044
Drug dose omission by device 20.98 10.51 24 540938 14492 110033845
Forced expiratory volume decreased 20.95 10.51 123 540839 13053 110035284
Portal hypertension 20.94 10.51 8 540954 8629 110039708
Dementia 20.76 10.51 82 540880 31591 110016746
Areflexia 20.66 10.51 4 540958 6765 110041572
Bone density decreased 20.61 10.51 29 540933 16013 110032324
Vertigo 20.50 10.51 300 540662 86570 109961767
Tachycardia 20.42 10.51 903 540059 225742 109822595
Lung consolidation 20.41 10.51 13 540949 10463 110037874
Myasthenia gravis 20.35 10.51 47 540915 21464 110026873
Thrombocytosis 20.30 10.51 13 540949 10431 110037906
Amniotic fluid index increased 20.29 10.51 10 540952 94 110048243
Bone pain 20.25 10.51 212 540750 64921 109983416
Spinal stenosis 20.24 10.51 39 540923 19017 110029320
Drug tolerance decreased 20.23 10.51 215 540747 27325 110021012
Stress 20.20 10.51 378 540584 104970 109943367
Sinus bradycardia 20.19 10.51 75 540887 29408 110018929
Tendonitis 20.14 10.51 63 540899 26020 110022317
Nocturnal fear 20.12 10.51 6 540956 10 110048327
Serum ferritin increased 20.10 10.51 17 540945 11830 110036507
Pneumonia klebsiella 20.07 10.51 4 540958 6628 110041709
Post procedural haemorrhage 19.97 10.51 28 540934 15484 110032853
Premature labour 19.86 10.51 10 540952 9162 110039175
Mouth haemorrhage 19.82 10.51 22 540940 13466 110034871
Breast cancer 19.82 10.51 109 540853 38433 110009904
Diabetes insipidus 19.80 10.51 4 540958 6566 110041771
Embolic stroke 19.74 10.51 9 540953 8734 110039603
Radiation inflammation 19.74 10.51 25 540937 1023 110047314
Lung adenocarcinoma 19.74 10.51 11 540951 9520 110038817
Intervertebral discitis 19.70 10.51 77 540885 6913 110041424
Rales 19.63 10.51 59 540903 24680 110023657
Anal fissure 19.62 10.51 12 540950 9869 110038468
Dissociation 19.47 10.51 12 540950 9830 110038507
Specific gravity urine increased 19.47 10.51 18 540944 512 110047825
Mental impairment 19.44 10.51 52 540910 22587 110025750
Aphthous ulcer 19.34 10.51 47 540915 21089 110027248
Sudden infant death syndrome 19.31 10.51 15 540947 334 110048003
Alcohol poisoning 19.28 10.51 10 540952 9010 110039327
Subileus 19.24 10.51 4 540958 6433 110041904
Presyncope 19.18 10.51 150 540812 48737 109999600
Lymphoedema 19.16 10.51 27 540935 14902 110033435
Atrial flutter 19.16 10.51 58 540904 24204 110024133
Colitis ischaemic 19.14 10.51 36 540926 17714 110030623
Central nervous system lesion 19.11 10.51 29 540933 15524 110032813
Pseudomembranous colitis 19.04 10.51 4 540958 6387 110041950
Gastric disorder 19.04 10.51 91 540871 33266 110015071
Diverticulum 19.03 10.51 29 540933 15497 110032840
Gastric ulcer haemorrhage 19.03 10.51 13 540949 10081 110038256
Oesophageal candidiasis 19.03 10.51 17 540945 11517 110036820
Breast cancer metastatic 19.03 10.51 16 540946 11165 110037172
Left ventricular hypertrophy 19.03 10.51 22 540940 13222 110035115
Arthritis bacterial 19.02 10.51 15 540947 10805 110037532
Blood creatine increased 18.98 10.51 17 540945 11504 110036833
Hypercapnia 18.95 10.51 16 540946 11143 110037194
Pregnancy on contraceptive 18.91 10.51 24 540938 984 110047353
Bradykinesia 18.90 10.51 15 540947 10773 110037564
Blood glucose fluctuation 18.88 10.51 7 540955 7691 110040646
Cyanosis 18.87 10.51 78 540884 29663 110018674
Postoperative wound infection 18.76 10.51 30 540932 15723 110032614
Retinal detachment 18.75 10.51 16 540946 11084 110037253
Hydrocephalus 18.72 10.51 14 540948 10361 110037976
Immune effector cell-associated neurotoxicity syndrome 18.71 10.51 27 540935 14755 110033582
Hyperpyrexia 18.70 10.51 8 540954 8061 110040276
Device leakage 18.70 10.51 31 540931 16017 110032320
Varices oesophageal 18.66 10.51 6 540956 7209 110041128
Neutrophilia 18.56 10.51 14 540948 10315 110038022
Anal inflammation 18.50 10.51 39 540923 2457 110045880
Hyperammonaemia 18.47 10.51 24 540938 13708 110034629
Endometrial ablation 18.47 10.51 23 540939 925 110047412
Hypertonia 18.45 10.51 9 540953 8397 110039940
Coronavirus infection 18.39 10.51 12 540950 9533 110038804
Pathological fracture 18.38 10.51 19 540943 12013 110036324
Dermatitis acneiform 18.33 10.51 21 540941 12674 110035663
Long QT syndrome 18.27 10.51 6 540956 7112 110041225
Total lung capacity decreased 18.25 10.51 6 540956 7108 110041229
Blood pressure diastolic decreased 18.17 10.51 102 540860 35783 110012554
Device issue 18.12 10.51 97 540865 34438 110013899
Rash papular 18.12 10.51 211 540751 27428 110020909
Device use error 18.10 10.51 11 540951 9078 110039259
Chemical submission 18.09 10.51 18 540944 562 110047775
Cerebral atrophy 18.08 10.51 11 540951 9074 110039263
Muscle atrophy 18 10.51 23 540939 13231 110035106
Sinus node dysfunction 17.94 10.51 11 540951 9036 110039301
Hepatitis C 17.94 10.51 21 540941 12552 110035785
Acute graft versus host disease in intestine 17.93 10.51 3 540959 5636 110042701
Bacterial test positive 17.92 10.51 82 540880 7895 110040442
Transplant failure 17.91 10.51 3 540959 5632 110042705
Haemoglobin abnormal 17.91 10.51 11 540951 9027 110039310
Pulmonary thrombosis 17.87 10.51 25 540937 13838 110034499
Thyroiditis 17.85 10.51 5 540957 6568 110041769
Joint stiffness 17.84 10.51 443 540519 66800 109981537
Hypotonia 17.81 10.51 31 540931 15714 110032623
Hepatomegaly 17.78 10.51 50 540912 21364 110026973
Red cell distribution width decreased 17.77 10.51 36 540926 2205 110046132
Amylase increased 17.77 10.51 21 540941 12498 110035839
Haemorrhoids 17.73 10.51 102 540860 35570 110012767
Suicidal ideation 17.72 10.51 338 540624 93599 109954738
Incontinence 17.70 10.51 34 540928 16601 110031736
Azotaemia 17.70 10.51 14 540948 10071 110038266
Blood culture positive 17.68 10.51 11 540951 8965 110039372
Bedridden 17.51 10.51 24 540938 13401 110034936
Endocarditis 17.35 10.51 24 540938 13347 110034990
Hernia 17.34 10.51 44 540918 19456 110028881
Anaemia macrocytic 17.32 10.51 7 540955 7296 110041041
Chest X-ray abnormal 17.28 10.51 10 540952 8477 110039860
Emphysema 17.25 10.51 45 540917 19711 110028626
Blood immunoglobulin A increased 17.24 10.51 29 540933 1539 110046798
Hypoproteinaemia 17.15 10.51 4 540958 5941 110042396
Leukoencephalopathy 17.12 10.51 12 540950 9183 110039154
Hyperammonaemic encephalopathy 17.04 10.51 3 540959 5431 110042906
Antinuclear antibody positive 17.03 10.51 12 540950 9156 110039181
Electrocardiogram ST segment elevation 17.00 10.51 12 540950 9148 110039189
Hyperuricaemia 17.00 10.51 28 540934 14503 110033834
Substance-induced psychotic disorder 16.99 10.51 3 540959 5421 110042916
Glaucoma 16.95 10.51 55 540907 22462 110025875
Brain abscess 16.88 10.51 6 540956 6768 110041569
Post procedural complication 16.86 10.51 70 540892 26588 110021749
Incoherent 16.80 10.51 10 540952 8348 110039989
Wound dehiscence 16.76 10.51 9 540953 7953 110040384
Clostridial infection 16.73 10.51 5 540957 6297 110042040
Overlap syndrome 16.69 10.51 88 540874 8971 110039366
Abnormal behaviour 16.65 10.51 117 540845 38922 110009415
Apathy 16.59 10.51 34 540928 16205 110032132
Thrombosis in device 16.57 10.51 3 540959 5324 110043013
Breast cancer female 16.56 10.51 22 540940 12446 110035891
Urticaria pressure 16.53 10.51 8 540954 72 110048265
Bacterial sepsis 16.45 10.51 16 540946 10410 110037927
Cytomegalovirus colitis 16.37 10.51 7 540955 7054 110041283
Lacrimation increased 16.35 10.51 227 540735 30723 110017614
Product dose omission issue 16.35 10.51 1353 539609 320429 109727908
Glomerular filtration rate increased 16.33 10.51 32 540930 1913 110046424
Drug-induced liver injury 16.31 10.51 731 540231 119336 109929001
Vitamin B12 increased 16.28 10.51 33 540929 2022 110046315
Diverticulum intestinal 16.27 10.51 20 540942 11699 110036638
Adenocarcinoma of colon 16.19 10.51 5 540957 6163 110042174
Abdominal wall haematoma 16.14 10.51 4 540958 5701 110042636
Cerebral haematoma 16.13 10.51 14 540948 9618 110038719
Psychomotor retardation 16.13 10.51 9 540953 7783 110040554
Micturition urgency 16.12 10.51 45 540917 19275 110029062
Pericardial haemorrhage 16.10 10.51 3 540959 5214 110043123
Hyperprolactinaemia 16.09 10.51 6 540956 6569 110041768
Congestive cardiomyopathy 16.08 10.51 28 540934 14191 110034146
Aortic valve incompetence 16.04 10.51 18 540944 10963 110037374
Product use in unapproved indication 16.03 10.51 2458 538504 444919 109603418
Terminal state 15.98 10.51 4 540958 5663 110042674
Decreased appetite 15.96 10.51 2061 538901 473785 109574552
Bundle branch block left 15.87 10.51 24 540938 12864 110035473
Macular degeneration 15.87 10.51 169 540793 21490 110026847
Anal fistula 15.86 10.51 11 540951 8462 110039875
Haemarthrosis 15.85 10.51 8 540954 7321 110041016
Fungaemia 15.85 10.51 5 540957 6081 110042256
Hepatosplenomegaly 15.82 10.51 7 540955 6912 110041425
Caesarean section 15.81 10.51 27 540935 13790 110034547
Body height decreased 15.77 10.51 17 540945 10546 110037791
Ventricular hypokinesia 15.71 10.51 19 540943 11195 110037142
Neurological decompensation 15.68 10.51 7 540955 6876 110041461
Fibrin D dimer increased 15.66 10.51 15 540947 9830 110038507
Radiculopathy 15.66 10.51 154 540808 19182 110029155
Burning sensation 15.65 10.51 241 540721 68971 109979366
Coronary artery stenosis 15.64 10.51 27 540935 13731 110034606
Duodenal ulcer haemorrhage 15.63 10.51 10 540952 8027 110040310
Muscle haemorrhage 15.62 10.51 7 540955 6862 110041475
Female genital tract fistula 15.61 10.51 136 540826 16383 110031954
Surgery 15.59 10.51 128 540834 41155 110007182
Gastrointestinal inflammation 15.57 10.51 14 540948 9455 110038882
Laryngeal stenosis 15.56 10.51 26 540936 1372 110046965
Spinal fusion surgery 15.56 10.51 87 540875 9069 110039268
Incorrect dose administered 15.48 10.51 387 540575 103254 109945083
Throat tightness 15.48 10.51 240 540722 33249 110015088
Limb injury 15.47 10.51 114 540848 37522 110010815
Bladder disorder 15.47 10.51 19 540943 11118 110037219
Bilirubin urine present 15.46 10.51 13 540949 325 110048012
Tongue disorder 15.41 10.51 29 540933 14269 110034068
Spinal osteoarthritis 15.40 10.51 49 540913 20134 110028203
Osteolysis 15.38 10.51 4 540958 5519 110042818
Nocturia 15.37 10.51 38 540924 16952 110031385
Chronic lymphocytic leukaemia 15.37 10.51 5 540957 5963 110042374
Paternal exposure during pregnancy 15.34 10.51 11 540951 216 110048121
Mycotic allergy 15.32 10.51 5 540957 5949 110042388
Swelling face 15.28 10.51 574 540388 91747 109956590
Metabolic encephalopathy 15.22 10.51 19 540943 11041 110037296
Accidental death 15.20 10.51 3 540959 5006 110043331
Polymenorrhoea 15.11 10.51 23 540939 1121 110047216
Kidney infection 15.10 10.51 69 540893 25530 110022807
Orthopnoea 15.10 10.51 19 540943 11002 110037335
Flank pain 15.09 10.51 60 540902 23070 110025267
Aplasia 15.03 10.51 10 540952 7863 110040474
International normalised ratio decreased 15.01 10.51 11 540951 8225 110040112
Mycobacterium avium complex infection 15.00 10.51 5 540957 5872 110042465
Aspartate aminotransferase 15.00 10.51 21 540941 948 110047389
Metastatic neoplasm 14.99 10.51 5 540957 5868 110042469
Scleritis 14.95 10.51 4 540958 5416 110042921
Foreign body in reproductive tract 14.92 10.51 21 540941 953 110047384
Chronic gastritis 14.91 10.51 4 540958 5407 110042930
Post procedural infection 14.89 10.51 28 540934 13781 110034556
Pulmonary artery stenosis congenital 14.77 10.51 5 540957 15 110048322
Eosinophilia 14.77 10.51 197 540765 57739 109990598
Exposure via ingestion 14.74 10.51 3 540959 4897 110043440
Urine odour abnormal 14.73 10.51 9 540953 7406 110040931
Granulocyte count increased 14.72 10.51 31 540931 1952 110046385
Mite allergy 14.70 10.51 5 540957 5798 110042539
Hepatic cyst 14.70 10.51 10 540952 7773 110040564
Cardiac dysfunction 14.70 10.51 6 540956 6217 110042120
Neuritis 14.67 10.51 9 540953 7390 110040947
Sickle cell anaemia with crisis 14.66 10.51 15 540947 9530 110038807
Foetal macrosomia 14.62 10.51 8 540954 95 110048242
Nasal congestion 14.61 10.51 604 540358 97678 109950659
Ventricular extrasystoles 14.60 10.51 59 540903 22582 110025755
Rash vesicular 14.57 10.51 122 540840 14530 110033807
Psychiatric decompensation 14.55 10.51 5 540957 5760 110042577
Skin discomfort 14.53 10.51 32 540930 2078 110046259
Jaundice 14.53 10.51 203 540759 59033 109989304
Concomitant disease aggravated 14.50 10.51 37 540925 16327 110032010
Device expulsion 14.48 10.51 90 540872 30801 110017536
Prevertebral soft tissue swelling of cervical space 14.45 10.51 6 540956 36 110048301
Systemic infection 14.44 10.51 16 540946 9803 110038534
Facial paralysis 14.44 10.51 65 540897 24149 110024188
Lung neoplasm 14.44 10.51 11 540951 8065 110040272
Bacterial test 14.44 10.51 23 540939 1166 110047171
Immobile 14.41 10.51 10 540952 7692 110040645
Upper limb fracture 14.39 10.51 53 540909 20835 110027502
Therapeutic reaction time decreased 14.36 10.51 4 540958 5275 110043062
Arteriospasm coronary 14.32 10.51 14 540948 9086 110039251
Allergy to arthropod bite 14.29 10.51 14 540948 429 110047908
Ischaemia 14.26 10.51 14 540948 9069 110039268
Toothache 14.23 10.51 63 540899 23512 110024825
Guillain-Barre syndrome 14.23 10.51 19 540943 10725 110037612
Fibrosis 14.20 10.51 10 540952 7632 110040705
Internal haemorrhage 14.18 10.51 17 540945 10054 110038283
Throat clearing 14.11 10.51 50 540912 4283 110044054
Cells in urine 14.09 10.51 10 540952 193 110048144
Periodontitis 14.07 10.51 4 540958 5204 110043133
Psoriasis 14.05 10.51 828 540134 139165 109909172
Cold urticaria 14.04 10.51 11 540951 248 110048089
Glomerulonephritis 14.01 10.51 3 540959 4727 110043610
Renal tubular acidosis 13.95 10.51 3 540959 4712 110043625
Stupor 13.85 10.51 12 540950 8253 110040084
Aortic arteriosclerosis 13.83 10.51 20 540942 10918 110037419
Phonophobia 13.80 10.51 17 540945 676 110047661
Myelopathy 13.79 10.51 5 540957 5571 110042766
Nitrite urine present 13.79 10.51 23 540939 1212 110047125
Monocyte percentage increased 13.73 10.51 33 540929 2270 110046067
Ventricular dysfunction 13.73 10.51 10 540952 7501 110040836
Peripheral vascular disorder 13.72 10.51 13 540949 8563 110039774
Transfusion 13.67 10.51 71 540891 25401 110022936
Malformation venous 13.67 10.51 4 540958 6 110048331
Lupus nephritis 13.65 10.51 3 540959 4642 110043695
Tooth infection 13.64 10.51 59 540903 22157 110026180
Injection site haemorrhage 13.59 10.51 100 540862 32928 110015409
Musculoskeletal chest pain 13.54 10.51 84 540878 28763 110019574
Large intestine polyp 13.53 10.51 34 540928 15083 110033254
Syringe issue 13.49 10.51 16 540946 9509 110038828
Bile duct stone 13.40 10.51 7 540955 6282 110042055
Total lung capacity abnormal 13.39 10.51 3 540959 4580 110043757
Plasma cell myeloma recurrent 13.37 10.51 9 540953 7033 110041304
Paraparesis 13.31 10.51 3 540959 4563 110043774
Embolism venous 13.31 10.51 4 540958 5019 110043318
Hypoventilation 13.22 10.51 12 540950 8069 110040268
Post-tussive vomiting 13.22 10.51 6 540956 46 110048291
Skin disorder 13.21 10.51 140 540822 42773 110005564
Supraventricular extrasystoles 13.20 10.51 12 540950 8061 110040276
Bilirubin conjugated increased 13.16 10.51 7 540955 6217 110042120
Disease complication 13.15 10.51 6 540956 5821 110042516
Drug abuser 13.13 10.51 5 540957 5404 110042933
Product substitution issue 13.11 10.51 63 540899 22998 110025339
Demyelination 13.09 10.51 85 540877 9344 110038993
Impaired quality of life 13.07 10.51 213 540749 29804 110018533
Paraplegia 13.07 10.51 7 540955 6193 110042144
Dysmetropsia 13.07 10.51 8 540954 119 110048218
Erysipelas 13.06 10.51 28 540934 13130 110035207
Skin cancer 13.00 10.51 44 540918 17740 110030597
Inhibitory drug interaction 13.00 10.51 4 540958 4943 110043394
Ischaemic cardiomyopathy 12.99 10.51 12 540950 7999 110040338
Disturbance in attention 12.93 10.51 396 540566 61599 109986738
Alcohol abuse 12.93 10.51 4 540958 4925 110043412
Large intestinal ulcer 12.90 10.51 6 540956 5755 110042582
Colitis microscopic 12.88 10.51 29 540933 13365 110034972
Enterococcal bacteraemia 12.87 10.51 3 540959 4458 110043879
Extrasystoles 12.86 10.51 13 540949 8305 110040032
Pre-eclampsia 12.83 10.51 14 540948 8636 110039701
Compression fracture 12.77 10.51 16 540946 9283 110039054
N-terminal prohormone brain natriuretic peptide increased 12.77 10.51 7 540955 6114 110042223
Renal function test abnormal 12.70 10.51 15 540947 8931 110039406
Lip pruritus 12.65 10.51 23 540939 1299 110047038
Venous thrombosis limb 12.56 10.51 5 540957 5260 110043077
Nasal pruritus 12.56 10.51 19 540943 921 110047416
Incorrect dose administered by device 12.55 10.51 9 540953 6805 110041532
Pelvic fracture 12.54 10.51 32 540930 14122 110034215
Urinary casts 12.53 10.51 23 540939 1309 110047028
Steroid diabetes 12.52 10.51 5 540957 5249 110043088
Swelling of eyelid 12.51 10.51 65 540897 6588 110041749
Petechiae 12.51 10.51 65 540897 23252 110025085
Coronary artery bypass 12.47 10.51 7 540955 6035 110042302
Escherichia bacteraemia 12.44 10.51 19 540943 10145 110038192
Sexual dysfunction 12.44 10.51 14 540948 8516 110039821
Phlebitis 12.43 10.51 18 540944 9823 110038514
Sudden cardiac death 12.42 10.51 6 540956 5631 110042706
Cushingoid 12.41 10.51 24 540938 11688 110036649
Odynophagia 12.40 10.51 32 540930 14069 110034268
Atrial thrombosis 12.39 10.51 3 540959 4343 110043994
Meningitis 12.38 10.51 24 540938 11678 110036659
Toe amputation 12.35 10.51 3 540959 4335 110044002
Vertigo CNS origin 12.33 10.51 5 540957 28 110048309
Peripheral ischaemia 12.30 10.51 22 540940 11036 110037301
Premenstrual syndrome 12.29 10.51 15 540947 591 110047746
Blindness unilateral 12.26 10.51 18 540944 9768 110038569
Occult blood positive 12.25 10.51 11 540951 7434 110040903
Lumbar vertebral fracture 12.24 10.51 16 540946 9115 110039222
International normalised ratio abnormal 12.24 10.51 8 540954 6349 110041988
Aortic valve stenosis 12.21 10.51 8 540954 6342 110041995
Empyema 12.17 10.51 6 540956 5564 110042773
Hyperthermia 12.16 10.51 58 540904 21214 110027123
Gingival pain 12.15 10.51 38 540924 15698 110032639
Sleep disorder due to general medical condition, hypersomnia type 12.11 10.51 29 540933 1990 110046347
Coma scale abnormal 12.08 10.51 18 540944 9708 110038629
Glycosylated haemoglobin increased 12.03 10.51 67 540895 23552 110024785
Gastrointestinal ulcer 12.02 10.51 3 540959 4257 110044080
Metastases to meninges 12.02 10.51 5 540957 5123 110043214
Urine bilirubin decreased 11.99 10.51 8 540954 139 110048198
Actinic keratosis 11.98 10.51 10 540952 7003 110041334
Erythema nodosum 11.98 10.51 9 540953 6644 110041693
Periorbital swelling 11.93 10.51 56 540906 5449 110042888
Alopecia universalis 11.92 10.51 12 540950 380 110047957
Pain in extremity 11.81 10.51 2150 538812 484968 109563369
Tardive dyskinesia 11.80 10.51 31 540931 13548 110034789
Hyperaesthesia 11.78 10.51 35 540927 14692 110033645
Vaginal haemorrhage 11.78 10.51 73 540889 25001 110023336
Electrocardiogram ST segment depression 11.75 10.51 6 540956 5455 110042882
Lichen nitidus 11.75 10.51 8 540954 144 110048193
Tibia fracture 11.74 10.51 9 540953 6576 110041761
Vascular pseudoaneurysm 11.73 10.51 3 540959 4187 110044150
Poor venous access 11.72 10.51 71 540891 24451 110023886
Ehlers-Danlos syndrome 11.70 10.51 11 540951 320 110048017
Foot fracture 11.68 10.51 75 540887 25471 110022866
Vitreous haemorrhage 11.67 10.51 4 540958 4616 110043721
Product administration error 11.63 10.51 121 540841 37096 110011241
Injection 11.58 10.51 4 540958 13 110048324
Erectile dysfunction 11.56 10.51 49 540913 18507 110029830
Optic ischaemic neuropathy 11.55 10.51 3 540959 4144 110044193
Focal segmental glomerulosclerosis 11.54 10.51 3 540959 4142 110044195
Withdrawal syndrome 11.53 10.51 98 540864 31282 110017055
Parosmia 11.52 10.51 30 540932 13150 110035187
Pancreatitis 11.47 10.51 359 540603 93174 109955163
Toxic skin eruption 11.47 10.51 83 540879 27432 110020905
Endotracheal intubation 11.47 10.51 8 540954 6136 110042201
Purpura 11.46 10.51 71 540891 24317 110024020
Alcohol use 11.45 10.51 3 540959 4119 110044218
Allergy test positive 11.41 10.51 18 540944 905 110047432
Miosis 11.39 10.51 62 540900 21921 110026416
Pneumonia pneumococcal 11.39 10.51 5 540957 4960 110043377
Refusal of treatment by patient 11.38 10.51 18 540944 9476 110038861
Renal cell carcinoma 11.38 10.51 12 540950 7518 110040819
Pharyngeal swelling 11.34 10.51 99 540863 11933 110036404
Dyslipidaemia 11.33 10.51 40 540922 15925 110032412
Vitamin D decreased 11.31 10.51 27 540935 12188 110036149
Blood creatinine decreased 11.26 10.51 17 540945 9120 110039217
Product prescribing issue 11.22 10.51 29 540933 12743 110035594
Pharyngeal enanthema 11.21 10.51 6 540956 68 110048269
Paternal exposure timing unspecified 11.21 10.51 6 540956 68 110048269
Asphyxia 11.21 10.51 34 540928 14181 110034156
Feeding disorder 11.21 10.51 60 540902 21302 110027035
Bezoar 11.17 10.51 3 540959 4051 110044286
Cardiac valve disease 11.16 10.51 9 540953 6412 110041925
Blood magnesium decreased 11.15 10.51 55 540907 19941 110028396
Eyelid ptosis 11.15 10.51 31 540931 13296 110035041
Pemphigoid 11.11 10.51 54 540908 19653 110028684
Gingivitis 11.10 10.51 21 540941 10310 110038027
Hypokinesia 11.07 10.51 62 540900 21764 110026573
Menstruation delayed 11.02 10.51 26 540936 1768 110046569
Accidental exposure to product 11.01 10.51 175 540787 49833 109998504
Polyp 10.97 10.51 20 540942 9960 110038377
Dysphonia 10.95 10.51 285 540677 75644 109972693
Eye haemorrhage 10.92 10.51 26 540936 11748 110036589
Metastases to peritoneum 10.88 10.51 7 540955 5603 110042734
Cholestatic liver injury 10.87 10.51 12 540950 7364 110040973
Pneumonia viral 10.86 10.51 24 540938 11133 110037204
Congestive hepatopathy 10.85 10.51 6 540956 5214 110043123
Eye injury 10.82 10.51 70 540892 7685 110040652
Immune thrombocytopenia 10.82 10.51 65 540897 22429 110025908
Joint effusion 10.81 10.51 59 540903 20846 110027491
Eye pain 10.81 10.51 176 540786 49923 109998414
Polydipsia 10.80 10.51 13 540949 7675 110040662
Bradyphrenia 10.79 10.51 26 540936 11702 110036635
Thrombophlebitis 10.77 10.51 13 540949 7666 110040671
Reaction to excipient 10.70 10.51 28 540934 2031 110046306
Biliary obstruction 10.69 10.51 7 540955 5551 110042786
Kounis syndrome 10.69 10.51 8 540954 5917 110042420
Hepatocellular carcinoma 10.68 10.51 20 540942 9860 110038477
Tongue pruritus 10.68 10.51 17 540945 861 110047476
Fine motor skill dysfunction 10.65 10.51 9 540953 6265 110042072
Injection site extravasation 10.63 10.51 21 540941 10148 110038189
Oesophageal ulcer 10.63 10.51 14 540948 7950 110040387
Hyperkeratosis 10.62 10.51 18 540944 9221 110039116
Asthma exercise induced 10.60 10.51 9 540953 228 110048109
Idiopathic angioedema 10.57 10.51 6 540956 77 110048260
Acute myeloid leukaemia recurrent 10.54 10.51 6 540956 5133 110043204
Genital pain 10.52 10.51 22 540940 1378 110046959

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AE07 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Piperazine derivatives
ATC S01GX12 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Other antiallergics
FDA MoA N0000000190 Histamine H1 Receptor Antagonists
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:37955 H<small><sub>1</sub></small>-receptor antagonist
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:77715 nasal decongestant
FDA EPC N0000175587 Histamine-1 Receptor Antagonist
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D039563 Histamine H1 Antagonists, Non-Sedating

Related Drugs by ATC class:

R06AE Piperazine derivatives 6 drugs
buclizinechlorcyclizinecyclizinelevocetirizinemeclozineoxatomide
S01GX Other antiallergics 12 drugs
alcaftadineazelastinebilastinecromoglicic acidemedastineepinastineketotifenlevocabastinelodoxamidenedocromilolopatadinespaglumic acid

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Chronic idiopathic urticaria indication 302162004
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Atopic dermatitis off-label use 24079001 DOID:3310
Urticaria off-label use 126485001
Glaucoma contraindication 23986001 DOID:1686
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic renal failure syndrome contraindication 90688005
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Angle-closure glaucoma contraindication 392291006 DOID:13550
Hypertensive urgency contraindication 443482000
Hemodialysis with High-Flux Membrane contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.03 acidic
pKa2 8.21 Basic
pKa3 3.72 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/ML (10MG/ML) QUZYTTIR ESTEVE N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 8513259 Feb. 11, 2030 METHOD OF INCREASING PEAK PLASMA OR ONSET OF PLASMA CONCENTRATION BY INTRAVENOUS INJECTION IN INDIVIDUALS IN NEED OF TREATMENT FOR ACUTE URTICARIA
10MG/ML (10MG/ML) QUZYTTIR ESTEVE N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 9119771 Feb. 11, 2030 TREATMENT OF ACUTE URTICARIA
10MG/ML (10MG/ML) QUZYTTIR ESTEVE N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 9180090 Feb. 11, 2030 TREATMENT OF ACUTE URTICARIA
10MG/ML (10MG/ML) QUZYTTIR ESTEVE N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 8263581 Feb. 28, 2030 TREATMENT OF ACUTE URTICARIA
10MG/ML (10MG/ML) QUZYTTIR ESTEVE N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 8314083 Feb. 28, 2030 METHOD OF TREATMENT IN PATIENTS WITH CONCOMITANT ANGIOEDEMA
EQ 0.24% BASE ZERVIATE HARROW EYE N208694 May 30, 2017 RX SOLUTION/DROPS OPHTHALMIC 8829005 March 15, 2030 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS
EQ 0.24% BASE ZERVIATE HARROW EYE N208694 May 30, 2017 RX SOLUTION/DROPS OPHTHALMIC 9993471 March 15, 2030 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 7.91 WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.52 CHEMBL
Angiopoietin-1 receptor Kinase Kd 4.05 CHEMBL

External reference:

IDSource
4024005 VUID
N0000022010 NUI
D00664 KEGG_DRUG
83881-52-1 SECONDARY_CAS_RN
203150 RXNORM
C0055147 UMLSCUI
CHEBI:3561 CHEBI
CHEMBL1000 ChEMBL_ID
CHEMBL1607273 ChEMBL_ID
DB00341 DRUGBANK_ID
D017332 MESH_DESCRIPTOR_UI
2678 PUBCHEM_CID
1222 IUPHAR_LIGAND_ID
5520 INN_ID
YO7261ME24 UNII
130140 MMSL
38293 MMSL
4399 MMSL
4400 MMSL
d03827 MMSL
003803 NDDF
003804 NDDF
108655000 SNOMEDCT_US
108656004 SNOMEDCT_US
372523007 SNOMEDCT_US
4020943 VANDF
4024005 VANDF
YO7261ME24 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense all day allergy d HUMAN OTC DRUG LABEL 2 0113-0147 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Good Sense Childrens All Day Allergy HUMAN OTC DRUG LABEL 1 0113-0189 SOLUTION 5 mg ORAL ANDA 16 sections
Good Sense Childrens All Day Allergy HUMAN OTC DRUG LABEL 1 0113-0503 SOLUTION 5 mg ORAL ANDA 16 sections
Good Sense All Day Allergy HUMAN OTC DRUG LABEL 1 0113-0981 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
All Day Allergy D HUMAN OTC DRUG LABEL 2 0113-2147 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Good Sense all day allergy HUMAN OTC DRUG LABEL 1 0113-9458 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
Cetirizine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0874 SOLUTION 1 mg ORAL ANDA 19 sections
Cetirizine Hydrochloride (Allergy) Human OTC Drug Label 1 0363-0068 CAPSULE 10 mg ORAL ANDA 16 sections
Cetirizine Hydrochloride Human OTC Drug Label 1 0363-0471 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 14 sections
Wal-Zyr HUMAN OTC DRUG LABEL 1 0363-0606 TABLET 10 mg ORAL ANDA 17 sections
Wal-Zyr D HUMAN OTC DRUG LABEL 2 0363-0989 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 17 sections
WAL ZYR D HUMAN OTC DRUG LABEL 2 0363-1147 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
24 HOUR ALLERGY HUMAN OTC DRUG LABEL 1 0363-1219 CAPSULE 10 mg ORAL NDA 17 sections
Allergy Relief HUMAN OTC DRUG LABEL 1 0363-1794 TABLET 10 mg ORAL ANDA 16 sections
Wal-Zyr Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-2088 SOLUTION 5 mg ORAL ANDA 17 sections
Wal-Zyr Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-2102 SOLUTION 5 mg ORAL ANDA 17 sections
Wal-Zyr All Day Allergy HUMAN OTC DRUG LABEL 1 0363-2106 SOLUTION 5 mg ORAL ANDA 17 sections
childrens allergy relief HUMAN OTC DRUG LABEL 1 0363-3311 SOLUTION 5 mg ORAL ANDA 16 sections
childrens allergy relief HUMAN OTC DRUG LABEL 1 0363-3393 SOLUTION 5 mg ORAL ANDA 16 sections
Childrens Cetirizine Hydrochloride Human OTC Drug Label 1 0363-4025 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 14 sections
allergy relief HUMAN OTC DRUG LABEL 1 0363-4101 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
allergy relief D12 HUMAN OTC DRUG LABEL 2 0363-4923 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Hives Relief HUMAN OTC DRUG LABEL 1 0363-6340 TABLET, FILM COATED 10 mg ORAL ANDA 17 sections
Cetirizine HCl HUMAN OTC DRUG LABEL 1 0363-6341 CAPSULE 10 mg ORAL NDA 17 sections
Cetirizine Hydrochloride (Allergy) Human OTC Drug Label 1 0363-9602 TABLET 10 mg ORAL ANDA 16 sections
Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-9899 TABLET 10 mg ORAL ANDA 15 sections
Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0378-3635 TABLET, FILM COATED 5 mg ORAL ANDA 16 sections
Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0378-3637 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
Rugby Cetirizine Hydrochloride and Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 2 0536-1279 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Cetirizine hydrochloride HUMAN OTC DRUG LABEL 1 0615-8479 TABLET, COATED 10 mg ORAL ANDA 15 sections