Stem definition | Drug id | CAS RN |
---|---|---|
diphenylmethyl piperazine derivatives | 581 | 83881-51-0 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.37 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 8, 1995 | FDA | J AND J CONSUMER INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pemphigus | 2620.44 | 10.29 | 3022 | 235180 | 117144 | 50249778 |
Systemic lupus erythematosus | 2323.71 | 10.29 | 3076 | 235126 | 137546 | 50229376 |
Glossodynia | 2181.01 | 10.29 | 2701 | 235501 | 112868 | 50254054 |
Hand deformity | 1584.56 | 10.29 | 2147 | 236055 | 98052 | 50268870 |
Abdominal discomfort | 1465.24 | 10.29 | 3309 | 234893 | 228332 | 50138590 |
Alopecia | 1448.32 | 10.29 | 3408 | 234794 | 241639 | 50125283 |
Swelling | 1389.36 | 10.29 | 2975 | 235227 | 197897 | 50169025 |
Wound | 1360.99 | 10.29 | 2055 | 236147 | 103739 | 50263183 |
Pericarditis | 1127.92 | 10.29 | 1609 | 236593 | 77080 | 50289842 |
Discomfort | 1108.57 | 10.29 | 1897 | 236305 | 106483 | 50260439 |
Contraindicated product administered | 1105.52 | 10.29 | 2272 | 235930 | 146686 | 50220236 |
Anti-cyclic citrullinated peptide antibody positive | 1009.53 | 10.29 | 1442 | 236760 | 69145 | 50297777 |
Hypersensitivity | 934.88 | 10.29 | 2668 | 235534 | 212493 | 50154429 |
Arthropathy | 868.30 | 10.29 | 2138 | 236064 | 155768 | 50211154 |
Maternal exposure during pregnancy | 844.52 | 10.29 | 2131 | 236071 | 157647 | 50209275 |
Pain | 721.65 | 10.29 | 4919 | 233283 | 573984 | 49792938 |
Muscle injury | 684.88 | 10.29 | 859 | 237343 | 36252 | 50330670 |
Duodenal ulcer perforation | 675.74 | 10.29 | 948 | 237254 | 44663 | 50322259 |
Folliculitis | 673.56 | 10.29 | 876 | 237326 | 38349 | 50328573 |
Infusion related reaction | 664.52 | 10.29 | 2028 | 236174 | 167529 | 50199393 |
Blister | 635.21 | 10.29 | 1305 | 236897 | 84113 | 50282809 |
Helicobacter infection | 630.41 | 10.29 | 960 | 237242 | 48742 | 50318180 |
Synovitis | 621.85 | 10.29 | 1621 | 236581 | 122244 | 50244678 |
Irritable bowel syndrome | 605.56 | 10.29 | 960 | 237242 | 50481 | 50316441 |
Hepatic enzyme increased | 589.25 | 10.29 | 1697 | 236505 | 135683 | 50231239 |
Death | 560.48 | 10.29 | 428 | 237774 | 324951 | 50041971 |
Rash | 541.49 | 10.29 | 3714 | 234488 | 433757 | 49933165 |
Rheumatoid factor positive | 489.77 | 10.29 | 858 | 237344 | 49001 | 50317921 |
Pruritus | 488.63 | 10.29 | 2625 | 235577 | 280943 | 50085979 |
Urticaria | 487.09 | 10.29 | 1528 | 236674 | 128033 | 50238889 |
Product use issue | 480.82 | 10.29 | 1672 | 236530 | 147803 | 50219119 |
Sinusitis | 461.50 | 10.29 | 1804 | 236398 | 168754 | 50198168 |
Lower respiratory tract infection | 443.25 | 10.29 | 1212 | 236990 | 93989 | 50272933 |
Sleep disorder due to general medical condition, insomnia type | 439.70 | 10.29 | 636 | 237566 | 30811 | 50336111 |
Joint swelling | 416.40 | 10.29 | 2262 | 235940 | 243024 | 50123898 |
Fatigue | 406.37 | 10.29 | 5091 | 233111 | 702510 | 49664412 |
Acute kidney injury | 398.71 | 10.29 | 295 | 237907 | 227763 | 50139159 |
Toxicity to various agents | 396.53 | 10.29 | 256 | 237946 | 212243 | 50154679 |
Anaemia | 379.90 | 10.29 | 377 | 237825 | 252079 | 50114843 |
Ill-defined disorder | 364.36 | 10.29 | 799 | 237403 | 53855 | 50313067 |
Impaired healing | 362.92 | 10.29 | 926 | 237276 | 68860 | 50298062 |
Therapeutic product effect decreased | 339.75 | 10.29 | 1404 | 236798 | 134646 | 50232276 |
Drug intolerance | 335.54 | 10.29 | 1966 | 236236 | 217138 | 50149784 |
Hip arthroplasty | 301.78 | 10.29 | 526 | 237676 | 29903 | 50337019 |
Completed suicide | 289.63 | 10.29 | 129 | 238073 | 131760 | 50235162 |
Fall | 284.46 | 10.29 | 732 | 237470 | 334200 | 50032722 |
Drug interaction | 283.38 | 10.29 | 313 | 237889 | 199308 | 50167614 |
Rheumatic fever | 257.74 | 10.29 | 356 | 237846 | 16511 | 50350411 |
Knee arthroplasty | 253.70 | 10.29 | 537 | 237665 | 35309 | 50331613 |
Gastrointestinal disorder | 245.33 | 10.29 | 987 | 237215 | 93469 | 50273453 |
Neutropenia | 241.27 | 10.29 | 205 | 237997 | 147760 | 50219162 |
Swollen joint count increased | 236.45 | 10.29 | 320 | 237882 | 14553 | 50352369 |
Rheumatoid arthritis | 232.55 | 10.29 | 1691 | 236511 | 200859 | 50166063 |
Hypotension | 220.86 | 10.29 | 488 | 237714 | 234981 | 50131941 |
Stomatitis | 220.01 | 10.29 | 1003 | 237199 | 100341 | 50266581 |
Pneumonia | 211.63 | 10.29 | 989 | 237213 | 377412 | 49989510 |
Asthma | 191.53 | 10.29 | 881 | 237321 | 88456 | 50278466 |
Thrombocytopenia | 191.38 | 10.29 | 191 | 238011 | 127482 | 50239440 |
Food allergy | 189.12 | 10.29 | 212 | 237990 | 7925 | 50358997 |
Diarrhoea | 183.28 | 10.29 | 1830 | 236372 | 586646 | 49780276 |
Sepsis | 174 | 10.29 | 222 | 237980 | 132703 | 50234219 |
Malignant neoplasm progression | 160.24 | 10.29 | 60 | 238142 | 68064 | 50298858 |
Nausea | 156.24 | 10.29 | 2361 | 235841 | 703037 | 49663885 |
Febrile neutropenia | 148.78 | 10.29 | 144 | 238058 | 97523 | 50269399 |
Hyponatraemia | 148.49 | 10.29 | 140 | 238062 | 95999 | 50270923 |
Type 2 diabetes mellitus | 148.34 | 10.29 | 426 | 237776 | 33949 | 50332973 |
Temperature regulation disorder | 145.33 | 10.29 | 136 | 238066 | 4091 | 50362831 |
Treatment failure | 137.06 | 10.29 | 1112 | 237090 | 136525 | 50230397 |
Myocardial infarction | 131.31 | 10.29 | 135 | 238067 | 88892 | 50278030 |
Pancytopenia | 129.02 | 10.29 | 123 | 238079 | 83907 | 50283015 |
Disease progression | 127.62 | 10.29 | 158 | 238044 | 95708 | 50271214 |
Septic shock | 126.89 | 10.29 | 55 | 238147 | 57120 | 50309802 |
Urinary tract infection | 122.33 | 10.29 | 590 | 237612 | 223430 | 50143492 |
Haemoglobin decreased | 122.15 | 10.29 | 260 | 237942 | 126956 | 50239966 |
Nasopharyngitis | 122.12 | 10.29 | 1417 | 236785 | 191510 | 50175412 |
Cardiac failure | 121.86 | 10.29 | 107 | 238095 | 75933 | 50290989 |
Cardio-respiratory arrest | 119.35 | 10.29 | 52 | 238150 | 53840 | 50313082 |
Contusion | 119.14 | 10.29 | 920 | 237282 | 111263 | 50255659 |
Coeliac disease | 117.49 | 10.29 | 173 | 238029 | 8512 | 50358410 |
Angioedema | 116.14 | 10.29 | 416 | 237786 | 37260 | 50329662 |
Blood creatinine increased | 115.16 | 10.29 | 113 | 238089 | 76047 | 50290875 |
Renal impairment | 114.70 | 10.29 | 112 | 238090 | 75549 | 50291373 |
Gastrointestinal haemorrhage | 114.12 | 10.29 | 106 | 238096 | 73215 | 50293707 |
Vomiting | 113.74 | 10.29 | 1508 | 236694 | 459250 | 49907672 |
Peripheral swelling | 111.97 | 10.29 | 1470 | 236732 | 204466 | 50162456 |
Cardiac failure congestive | 109.27 | 10.29 | 142 | 238060 | 84240 | 50282682 |
Renal failure | 108.25 | 10.29 | 211 | 237991 | 106422 | 50260500 |
Atrial fibrillation | 107.98 | 10.29 | 196 | 238006 | 101549 | 50265373 |
Depressed level of consciousness | 107.56 | 10.29 | 55 | 238147 | 51898 | 50315024 |
Dehydration | 105.43 | 10.29 | 366 | 237836 | 152083 | 50214839 |
Leukopenia | 102.32 | 10.29 | 100 | 238102 | 67428 | 50299494 |
Metabolic acidosis | 102.28 | 10.29 | 28 | 238174 | 38797 | 50328125 |
Weight increased | 101.89 | 10.29 | 1422 | 236780 | 200469 | 50166453 |
Respiratory failure | 94.67 | 10.29 | 178 | 238024 | 91003 | 50275919 |
Infection | 92.07 | 10.29 | 1230 | 236972 | 171724 | 50195198 |
Multiple organ dysfunction syndrome | 91.88 | 10.29 | 62 | 238140 | 50275 | 50316647 |
International normalised ratio increased | 88.85 | 10.29 | 46 | 238156 | 43106 | 50323816 |
Coma | 87.60 | 10.29 | 83 | 238119 | 56796 | 50310126 |
Blood cholesterol increased | 86.52 | 10.29 | 499 | 237703 | 54716 | 50312206 |
Platelet count decreased | 84.57 | 10.29 | 221 | 237981 | 100505 | 50266417 |
Muscle spasticity | 83.07 | 10.29 | 222 | 237980 | 16962 | 50349960 |
Overdose | 82.82 | 10.29 | 220 | 237982 | 99507 | 50267415 |
Cerebrovascular accident | 82.37 | 10.29 | 204 | 237998 | 94476 | 50272446 |
Rhabdomyolysis | 81.26 | 10.29 | 41 | 238161 | 38986 | 50327936 |
Cardiac arrest | 80.23 | 10.29 | 171 | 238031 | 83480 | 50283442 |
Wheezing | 79.82 | 10.29 | 533 | 237669 | 61514 | 50305408 |
Interstitial lung disease | 79.11 | 10.29 | 80 | 238122 | 53096 | 50313826 |
Hypokalaemia | 78.59 | 10.29 | 187 | 238015 | 87805 | 50279117 |
Pleural effusion | 78.55 | 10.29 | 166 | 238036 | 81288 | 50285634 |
Ear pain | 76.93 | 10.29 | 300 | 237902 | 27983 | 50338939 |
Oedema peripheral | 76.62 | 10.29 | 433 | 237769 | 157528 | 50209394 |
Haemorrhage | 75.48 | 10.29 | 84 | 238118 | 53357 | 50313565 |
Electric shock | 71.61 | 10.29 | 50 | 238152 | 978 | 50365944 |
Decreased appetite | 70.71 | 10.29 | 605 | 237597 | 200318 | 50166604 |
Asthenia | 69.79 | 10.29 | 1069 | 237133 | 317973 | 50048949 |
Pneumonia aspiration | 68.51 | 10.29 | 30 | 238172 | 30974 | 50335948 |
Crystal urine present | 67.89 | 10.29 | 56 | 238146 | 1418 | 50365504 |
Intentional product use issue | 67.80 | 10.29 | 605 | 237597 | 76313 | 50290609 |
Bone marrow failure | 67.21 | 10.29 | 23 | 238179 | 27601 | 50339321 |
Hypoglycaemia | 66.48 | 10.29 | 93 | 238109 | 53488 | 50313434 |
Intentional overdose | 65.77 | 10.29 | 121 | 238081 | 62383 | 50304539 |
Weight decreased | 65.19 | 10.29 | 696 | 237506 | 220549 | 50146373 |
Pain in extremity | 64.62 | 10.29 | 900 | 237302 | 271965 | 50094957 |
Respiratory disorder | 64.15 | 10.29 | 304 | 237898 | 30883 | 50336039 |
Anaphylactic reaction | 63.99 | 10.29 | 455 | 237747 | 53600 | 50313322 |
Seizure | 63.93 | 10.29 | 311 | 237891 | 117563 | 50249359 |
Night sweats | 63.85 | 10.29 | 320 | 237882 | 33254 | 50333668 |
Drug abuse | 63.73 | 10.29 | 115 | 238087 | 59731 | 50307191 |
Lactic acidosis | 63.72 | 10.29 | 39 | 238163 | 33316 | 50333606 |
White blood cell count decreased | 62.13 | 10.29 | 310 | 237892 | 116412 | 50250510 |
Drug resistance | 62.09 | 10.29 | 8 | 238194 | 18981 | 50347941 |
Urinary sediment present | 60.78 | 10.29 | 60 | 238142 | 1931 | 50364991 |
Herpes zoster | 59.64 | 10.29 | 155 | 238047 | 70631 | 50296291 |
Hypercalcaemia | 59.37 | 10.29 | 18 | 238184 | 23334 | 50343588 |
Hyperkalaemia | 59.13 | 10.29 | 84 | 238118 | 48005 | 50318917 |
Liver function test abnormal | 58.02 | 10.29 | 74 | 238128 | 44265 | 50322657 |
Macular degeneration | 57.94 | 10.29 | 174 | 238028 | 14214 | 50352708 |
Cytomegalovirus infection | 57.70 | 10.29 | 8 | 238194 | 17954 | 50348968 |
Body temperature increased | 57.70 | 10.29 | 296 | 237906 | 31045 | 50335877 |
Premature delivery | 57.06 | 10.29 | 20 | 238182 | 23643 | 50343279 |
Shock | 56.09 | 10.29 | 14 | 238188 | 20636 | 50346286 |
Respiratory arrest | 56.06 | 10.29 | 36 | 238166 | 29973 | 50336949 |
Mucosal inflammation | 55.70 | 10.29 | 64 | 238138 | 40078 | 50326844 |
Chronic kidney disease | 55.63 | 10.29 | 63 | 238139 | 39708 | 50327214 |
Blood immunoglobulin E increased | 54.03 | 10.29 | 61 | 238141 | 2298 | 50364624 |
Hepatic function abnormal | 52.32 | 10.29 | 46 | 238156 | 32635 | 50334287 |
Therapeutic product effect incomplete | 52.24 | 10.29 | 237 | 237965 | 91278 | 50275644 |
Loss of consciousness | 51.69 | 10.29 | 284 | 237918 | 104069 | 50262853 |
Live birth | 51.26 | 10.29 | 182 | 238020 | 16226 | 50350696 |
Haemoglobin urine present | 51.07 | 10.29 | 37 | 238165 | 769 | 50366153 |
Alanine aminotransferase increased | 50.93 | 10.29 | 228 | 237974 | 88131 | 50278791 |
Drug level increased | 50.55 | 10.29 | 14 | 238188 | 19254 | 50347668 |
Altered state of consciousness | 50.34 | 10.29 | 20 | 238182 | 21890 | 50345032 |
Unresponsive to stimuli | 50.33 | 10.29 | 42 | 238160 | 30567 | 50336355 |
Immunodeficiency | 50.27 | 10.29 | 169 | 238033 | 14659 | 50352263 |
Skin ulcer | 49.34 | 10.29 | 56 | 238146 | 35262 | 50331660 |
Off label use | 48.97 | 10.29 | 1784 | 236418 | 472642 | 49894280 |
Drug hypersensitivity | 48.58 | 10.29 | 860 | 237342 | 250150 | 50116772 |
Pulmonary oedema | 47.79 | 10.29 | 99 | 238103 | 48839 | 50318083 |
Osteonecrosis of jaw | 47.17 | 10.29 | 50 | 238152 | 32476 | 50334446 |
Confusional state | 47.11 | 10.29 | 1177 | 237025 | 184751 | 50182171 |
Dermatitis atopic | 46.45 | 10.29 | 70 | 238132 | 3516 | 50363406 |
Infective pulmonary exacerbation of cystic fibrosis | 46.42 | 10.29 | 110 | 238092 | 7799 | 50359123 |
Lymphocyte percentage decreased | 46.34 | 10.29 | 61 | 238141 | 2699 | 50364223 |
Neurotoxicity | 46.33 | 10.29 | 7 | 238195 | 14733 | 50352189 |
C-reactive protein increased | 46.31 | 10.29 | 159 | 238043 | 66315 | 50300607 |
Drug ineffective | 45.83 | 10.29 | 4461 | 233741 | 814872 | 49552050 |
Cellulitis | 45.59 | 10.29 | 175 | 238027 | 70623 | 50296299 |
Acute myeloid leukaemia | 45.50 | 10.29 | 8 | 238194 | 15066 | 50351856 |
Melaena | 45.24 | 10.29 | 36 | 238166 | 26828 | 50340094 |
Hypocalcaemia | 45.08 | 10.29 | 36 | 238166 | 26780 | 50340142 |
Hereditary angioedema | 45.00 | 10.29 | 87 | 238115 | 5355 | 50361567 |
Urine abnormality | 44.75 | 10.29 | 94 | 238108 | 6144 | 50360778 |
Neoplasm progression | 44.36 | 10.29 | 43 | 238159 | 29114 | 50337808 |
Gait disturbance | 43.70 | 10.29 | 473 | 237729 | 149532 | 50217390 |
Femur fracture | 43.57 | 10.29 | 68 | 238134 | 37396 | 50329526 |
Rash erythematous | 43.37 | 10.29 | 297 | 237905 | 34555 | 50332367 |
Hepatic failure | 43.15 | 10.29 | 53 | 238149 | 32230 | 50334692 |
Ascites | 42.75 | 10.29 | 64 | 238138 | 35797 | 50331125 |
Rheumatoid nodule | 42.53 | 10.29 | 5 | 238197 | 12730 | 50354192 |
Aspartate aminotransferase increased | 42.16 | 10.29 | 206 | 237996 | 77792 | 50289130 |
Foetal exposure during pregnancy | 42.03 | 10.29 | 40 | 238162 | 27319 | 50339603 |
Blood pressure fluctuation | 40.74 | 10.29 | 66 | 238136 | 35757 | 50331165 |
Disseminated intravascular coagulation | 40.43 | 10.29 | 15 | 238187 | 17120 | 50349802 |
Encephalopathy | 40.35 | 10.29 | 60 | 238142 | 33651 | 50333271 |
Mental status changes | 40.16 | 10.29 | 68 | 238134 | 36204 | 50330718 |
White blood cells urine positive | 40.09 | 10.29 | 75 | 238127 | 4503 | 50362419 |
Rectal haemorrhage | 39.36 | 10.29 | 76 | 238126 | 38482 | 50328440 |
Pericardial effusion | 38.63 | 10.29 | 38 | 238164 | 25551 | 50341371 |
Premature baby | 38.57 | 10.29 | 19 | 238183 | 18318 | 50348604 |
Urticaria chronic | 38.39 | 10.29 | 26 | 238176 | 483 | 50366439 |
Localised infection | 38.29 | 10.29 | 38 | 238164 | 25447 | 50341475 |
Acute myocardial infarction | 38.15 | 10.29 | 49 | 238153 | 29224 | 50337698 |
Osteonecrosis | 38.14 | 10.29 | 30 | 238172 | 22487 | 50344435 |
Blood creatine phosphokinase increased | 37.71 | 10.29 | 41 | 238161 | 26326 | 50340596 |
Fracture | 37.65 | 10.29 | 16 | 238186 | 16817 | 50350105 |
Disease recurrence | 37.63 | 10.29 | 24 | 238178 | 20057 | 50346865 |
Osteomyelitis | 37.58 | 10.29 | 30 | 238172 | 22323 | 50344599 |
Red blood cells urine positive | 37.14 | 10.29 | 55 | 238147 | 2720 | 50364202 |
Transaminases increased | 36.85 | 10.29 | 46 | 238156 | 27778 | 50339144 |
Pneumonitis | 36.82 | 10.29 | 51 | 238151 | 29459 | 50337463 |
Proteinuria | 36.76 | 10.29 | 16 | 238186 | 16581 | 50350341 |
Hypomagnesaemia | 36.58 | 10.29 | 33 | 238169 | 23123 | 50343799 |
Hypoxia | 36.48 | 10.29 | 121 | 238081 | 51002 | 50315920 |
Neutrophil percentage increased | 36.42 | 10.29 | 54 | 238148 | 2673 | 50364249 |
Palmar-plantar erythrodysaesthesia syndrome | 36.34 | 10.29 | 25 | 238177 | 20073 | 50346849 |
Liver injury | 36.15 | 10.29 | 220 | 237982 | 24586 | 50342336 |
Extrapyramidal disorder | 36.07 | 10.29 | 6 | 238196 | 11764 | 50355158 |
Temperature intolerance | 36.03 | 10.29 | 97 | 238105 | 7442 | 50359480 |
Peritonitis | 35.80 | 10.29 | 14 | 238188 | 15472 | 50351450 |
Lung neoplasm malignant | 35.79 | 10.29 | 14 | 238188 | 15470 | 50351452 |
Agranulocytosis | 35.70 | 10.29 | 29 | 238173 | 21392 | 50345530 |
Cerebral haemorrhage | 35.54 | 10.29 | 45 | 238157 | 27007 | 50339915 |
Chronic spontaneous urticaria | 35.37 | 10.29 | 25 | 238177 | 499 | 50366423 |
Myelosuppression | 35.13 | 10.29 | 10 | 238192 | 13507 | 50353415 |
Colitis | 35.09 | 10.29 | 81 | 238121 | 38448 | 50328474 |
Musculoskeletal pain | 34.88 | 10.29 | 198 | 238004 | 71979 | 50294943 |
Injury | 34.83 | 10.29 | 368 | 237834 | 48557 | 50318365 |
Tubulointerstitial nephritis | 34.76 | 10.29 | 14 | 238188 | 15197 | 50351725 |
Serotonin syndrome | 34.72 | 10.29 | 39 | 238163 | 24674 | 50342248 |
Post-traumatic stress disorder | 34.62 | 10.29 | 68 | 238134 | 4235 | 50362687 |
Wrong technique in product usage process | 34.59 | 10.29 | 139 | 238063 | 55371 | 50311551 |
Hyperglycaemia | 34.41 | 10.29 | 75 | 238127 | 36330 | 50330592 |
Haematuria | 34.29 | 10.29 | 42 | 238160 | 25571 | 50341351 |
Red blood cell sedimentation rate abnormal | 34.27 | 10.29 | 17 | 238185 | 16326 | 50350596 |
Neutrophil count decreased | 34.19 | 10.29 | 107 | 238095 | 45919 | 50321003 |
Product prescribing error | 34.17 | 10.29 | 29 | 238173 | 20932 | 50345990 |
Hepatotoxicity | 34.02 | 10.29 | 47 | 238155 | 27179 | 50339743 |
Bursitis | 33.98 | 10.29 | 199 | 238003 | 21936 | 50344986 |
Renal tubular necrosis | 33.94 | 10.29 | 4 | 238198 | 10164 | 50356758 |
Intentional product misuse | 33.77 | 10.29 | 110 | 238092 | 46624 | 50320298 |
C-reactive protein abnormal | 33.77 | 10.29 | 49 | 238153 | 27760 | 50339162 |
Blood glucose increased | 33.75 | 10.29 | 197 | 238005 | 71127 | 50295795 |
Inappropriate antidiuretic hormone secretion | 33.65 | 10.29 | 10 | 238192 | 13133 | 50353789 |
Plasma cell myeloma | 33.51 | 10.29 | 60 | 238142 | 31262 | 50335660 |
Hip fracture | 33.18 | 10.29 | 44 | 238158 | 25887 | 50341035 |
Throat irritation | 33.18 | 10.29 | 250 | 237952 | 29989 | 50336933 |
Haematochezia | 33.08 | 10.29 | 88 | 238114 | 39794 | 50327128 |
Accidental exposure to product | 32.82 | 10.29 | 36 | 238166 | 23021 | 50343901 |
Neonatal hypoacusis | 32.74 | 10.29 | 10 | 238192 | 20 | 50366902 |
Auditory neuropathy spectrum disorder | 32.42 | 10.29 | 10 | 238192 | 21 | 50366901 |
Sleep disorder | 32.35 | 10.29 | 412 | 237790 | 56871 | 50310051 |
Acute respiratory distress syndrome | 32.23 | 10.29 | 31 | 238171 | 21068 | 50345854 |
Thrombosis | 32.21 | 10.29 | 144 | 238058 | 55689 | 50311233 |
Haematoma | 32.14 | 10.29 | 59 | 238143 | 30451 | 50336471 |
Perfume sensitivity | 32.05 | 10.29 | 25 | 238177 | 583 | 50366339 |
Blood bilirubin increased | 31.97 | 10.29 | 64 | 238138 | 31974 | 50334948 |
Blood lactate dehydrogenase increased | 31.97 | 10.29 | 27 | 238175 | 19535 | 50347387 |
Pulmonary embolism | 31.94 | 10.29 | 315 | 237887 | 101389 | 50265533 |
Metastases to central nervous system | 31.93 | 10.29 | 7 | 238195 | 11275 | 50355647 |
Acute hepatic failure | 31.84 | 10.29 | 17 | 238185 | 15660 | 50351262 |
Bacteraemia | 31.83 | 10.29 | 14 | 238188 | 14419 | 50352503 |
Intervertebral discitis | 31.81 | 10.29 | 50 | 238152 | 2606 | 50364316 |
Somnolence | 31.56 | 10.29 | 526 | 237676 | 154459 | 50212463 |
Cardiomyopathy | 31.51 | 10.29 | 17 | 238185 | 15569 | 50351353 |
Product dose omission issue | 31.19 | 10.29 | 644 | 237558 | 183194 | 50183728 |
Neuropathy peripheral | 31.09 | 10.29 | 298 | 237904 | 96459 | 50270463 |
Electrocardiogram QT prolonged | 31.04 | 10.29 | 132 | 238070 | 51754 | 50315168 |
Respiratory depression | 31.00 | 10.29 | 9 | 238193 | 12001 | 50354921 |
Breast cancer | 30.96 | 10.29 | 101 | 238101 | 42789 | 50324133 |
Posterior reversible encephalopathy syndrome | 30.60 | 10.29 | 16 | 238186 | 14912 | 50352010 |
Cerebral infarction | 30.45 | 10.29 | 34 | 238168 | 21570 | 50345352 |
Skin necrosis | 30.23 | 10.29 | 7 | 238195 | 10860 | 50356062 |
Orthostatic hypotension | 30.19 | 10.29 | 58 | 238144 | 29423 | 50337499 |
Metastases to liver | 30.18 | 10.29 | 30 | 238172 | 20074 | 50346848 |
Muscular weakness | 29.95 | 10.29 | 294 | 237908 | 94719 | 50272203 |
Abdominal pain | 29.84 | 10.29 | 865 | 237337 | 235363 | 50131559 |
Gamma-glutamyltransferase increased | 29.71 | 10.29 | 59 | 238143 | 29564 | 50337358 |
Pain in jaw | 29.50 | 10.29 | 88 | 238114 | 38340 | 50328582 |
Headache | 29.35 | 10.29 | 2766 | 235436 | 503769 | 49863153 |
Arthralgia | 29.33 | 10.29 | 2421 | 235781 | 436281 | 49930641 |
Inflammation | 29.22 | 10.29 | 153 | 238049 | 56759 | 50310163 |
Psychotic disorder | 28.95 | 10.29 | 36 | 238166 | 21776 | 50345146 |
Electrolyte imbalance | 28.92 | 10.29 | 23 | 238179 | 17146 | 50349776 |
Shock haemorrhagic | 28.56 | 10.29 | 3 | 238199 | 8341 | 50358581 |
Eosinophilic colitis | 28.53 | 10.29 | 14 | 238188 | 136 | 50366786 |
Constipation | 28.50 | 10.29 | 661 | 237541 | 185047 | 50181875 |
Dizziness | 28.32 | 10.29 | 1337 | 236865 | 345032 | 50021890 |
Tremor | 28.21 | 10.29 | 376 | 237826 | 114527 | 50252395 |
Oral pruritus | 28.04 | 10.29 | 37 | 238165 | 1641 | 50365281 |
Oliguria | 28.01 | 10.29 | 3 | 238199 | 8213 | 50358709 |
Tachycardia | 27.68 | 10.29 | 318 | 237884 | 99445 | 50267477 |
Upper gastrointestinal haemorrhage | 27.62 | 10.29 | 21 | 238181 | 16014 | 50350908 |
Urine leukocyte esterase positive | 27.49 | 10.29 | 49 | 238153 | 2834 | 50364088 |
Cardiogenic shock | 27.42 | 10.29 | 20 | 238182 | 15579 | 50351343 |
Inappropriate schedule of product administration | 27.19 | 10.29 | 212 | 237990 | 71619 | 50295303 |
Haematemesis | 27.14 | 10.29 | 56 | 238146 | 27669 | 50339253 |
Transplant rejection | 27.11 | 10.29 | 6 | 238196 | 9603 | 50357319 |
Hypertensive crisis | 27.11 | 10.29 | 14 | 238188 | 13140 | 50353782 |
Creatinine renal clearance decreased | 27.04 | 10.29 | 11 | 238191 | 11870 | 50355052 |
Left ventricular dysfunction | 26.88 | 10.29 | 8 | 238194 | 10498 | 50356424 |
Pulmonary hypertension | 26.76 | 10.29 | 75 | 238127 | 33342 | 50333580 |
Neoplasm malignant | 26.68 | 10.29 | 44 | 238158 | 23671 | 50343251 |
Arthritis | 26.64 | 10.29 | 270 | 237932 | 86451 | 50280471 |
Haematotoxicity | 26.62 | 10.29 | 3 | 238199 | 7892 | 50359030 |
Gastric ulcer | 26.40 | 10.29 | 37 | 238165 | 21268 | 50345654 |
Subdural haematoma | 26.36 | 10.29 | 14 | 238188 | 12933 | 50353989 |
Anuria | 26.27 | 10.29 | 10 | 238192 | 11234 | 50355688 |
Leukocytosis | 26.24 | 10.29 | 41 | 238161 | 22538 | 50344384 |
Vocal cord dysfunction | 26.05 | 10.29 | 18 | 238184 | 346 | 50366576 |
Cardiac disorder | 25.92 | 10.29 | 109 | 238093 | 42870 | 50324052 |
Generalised tonic-clonic seizure | 25.87 | 10.29 | 53 | 238149 | 26257 | 50340665 |
Thrombotic microangiopathy | 25.82 | 10.29 | 5 | 238197 | 8786 | 50358136 |
Forced expiratory volume decreased | 25.66 | 10.29 | 61 | 238141 | 4333 | 50362589 |
Agitation | 25.49 | 10.29 | 147 | 238055 | 53237 | 50313685 |
Loss of personal independence in daily activities | 25.47 | 10.29 | 209 | 237993 | 69841 | 50297081 |
Therapeutic response decreased | 25.36 | 10.29 | 125 | 238077 | 47106 | 50319816 |
Tachypnoea | 25.22 | 10.29 | 19 | 238183 | 14558 | 50352364 |
Tuberculosis | 25.22 | 10.29 | 8 | 238194 | 10075 | 50356847 |
Urine analysis abnormal | 24.99 | 10.29 | 60 | 238142 | 4290 | 50362632 |
Prescribed overdose | 24.88 | 10.29 | 135 | 238067 | 14465 | 50352457 |
Drug tolerance decreased | 24.77 | 10.29 | 97 | 238105 | 9063 | 50357859 |
Blood calcium decreased | 24.64 | 10.29 | 37 | 238165 | 20669 | 50346253 |
Hospitalisation | 24.56 | 10.29 | 203 | 237999 | 67734 | 50299188 |
Pancreatitis | 24.52 | 10.29 | 110 | 238092 | 42504 | 50324418 |
Adjustment disorder with depressed mood | 24.52 | 10.29 | 46 | 238156 | 2768 | 50364154 |
Diabetes mellitus | 24.51 | 10.29 | 133 | 238069 | 48900 | 50318022 |
Mastocytosis | 24.49 | 10.29 | 20 | 238182 | 499 | 50366423 |
Pancreatitis acute | 24.25 | 10.29 | 47 | 238155 | 23765 | 50343157 |
Syncope | 24.23 | 10.29 | 340 | 237862 | 102662 | 50264260 |
Stress cardiomyopathy | 24.22 | 10.29 | 4 | 238198 | 7883 | 50359039 |
Blood pressure diastolic abnormal | 24.19 | 10.29 | 7 | 238195 | 9354 | 50357568 |
Maternal exposure timing unspecified | 24.18 | 10.29 | 53 | 238149 | 3567 | 50363355 |
Chest pain | 24.04 | 10.29 | 641 | 237561 | 176241 | 50190681 |
Blood potassium increased | 24.01 | 10.29 | 25 | 238177 | 16373 | 50350549 |
Basal cell carcinoma | 23.87 | 10.29 | 46 | 238156 | 23310 | 50343612 |
Injection site pain | 23.86 | 10.29 | 373 | 237829 | 110651 | 50256271 |
Bone disorder | 23.81 | 10.29 | 32 | 238170 | 18720 | 50348202 |
Urticaria thermal | 23.69 | 10.29 | 13 | 238189 | 162 | 50366760 |
Victim of chemical submission | 23.66 | 10.29 | 15 | 238187 | 248 | 50366674 |
Myoclonus | 23.61 | 10.29 | 20 | 238182 | 14450 | 50352472 |
Mast cell activation syndrome | 23.60 | 10.29 | 17 | 238185 | 350 | 50366572 |
Enthesopathy | 23.59 | 10.29 | 3 | 238199 | 7190 | 50359732 |
Metastases to bone | 23.57 | 10.29 | 30 | 238172 | 17965 | 50348957 |
Bradycardia | 23.52 | 10.29 | 192 | 238010 | 64234 | 50302688 |
Acute respiratory failure | 23.49 | 10.29 | 64 | 238138 | 28718 | 50338204 |
Nervous system disorder | 23.45 | 10.29 | 25 | 238177 | 16198 | 50350724 |
Therapy cessation | 23.43 | 10.29 | 55 | 238147 | 25956 | 50340966 |
Labelled drug-drug interaction medication error | 23.36 | 10.29 | 10 | 238192 | 10467 | 50356455 |
Head deformity | 23.33 | 10.29 | 11 | 238191 | 97 | 50366825 |
Skin plaque | 23.13 | 10.29 | 74 | 238128 | 6254 | 50360668 |
Hypophagia | 23.13 | 10.29 | 61 | 238141 | 27667 | 50339255 |
Cardiotoxicity | 22.88 | 10.29 | 3 | 238199 | 7024 | 50359898 |
Scratch | 22.87 | 10.29 | 63 | 238139 | 4899 | 50362023 |
Sinus disorder | 22.79 | 10.29 | 157 | 238045 | 18301 | 50348621 |
Cystitis | 22.76 | 10.29 | 120 | 238082 | 44444 | 50322478 |
Panniculitis | 22.64 | 10.29 | 6 | 238196 | 8497 | 50358425 |
Spinal compression fracture | 22.54 | 10.29 | 16 | 238186 | 12640 | 50354282 |
Cestode infection | 22.46 | 10.29 | 15 | 238187 | 272 | 50366650 |
Transient ischaemic attack | 22.46 | 10.29 | 77 | 238125 | 32133 | 50334789 |
Eczema | 22.32 | 10.29 | 183 | 238019 | 22519 | 50344403 |
Epistaxis | 22.26 | 10.29 | 193 | 238009 | 63761 | 50303161 |
Accidental overdose | 22.19 | 10.29 | 36 | 238166 | 19497 | 50347425 |
Allergy test positive | 22.10 | 10.29 | 17 | 238185 | 388 | 50366534 |
Polyneuropathy | 22.05 | 10.29 | 15 | 238187 | 12116 | 50354806 |
Nocturnal fear | 22.05 | 10.29 | 6 | 238196 | 6 | 50366916 |
Influenza | 21.97 | 10.29 | 293 | 237909 | 89245 | 50277677 |
Clostridium difficile colitis | 21.80 | 10.29 | 31 | 238171 | 17711 | 50349211 |
Lichen sclerosus | 21.76 | 10.29 | 25 | 238177 | 960 | 50365962 |
Cataract | 21.66 | 10.29 | 132 | 238070 | 47168 | 50319754 |
Akathisia | 21.55 | 10.29 | 6 | 238196 | 8223 | 50358699 |
Sedation | 21.46 | 10.29 | 73 | 238129 | 30537 | 50336385 |
Cystic fibrosis pancreatic | 21.35 | 10.29 | 9 | 238193 | 59 | 50366863 |
Status epilepticus | 21.30 | 10.29 | 19 | 238183 | 13387 | 50353535 |
Bronchial neoplasm | 21.10 | 10.29 | 17 | 238185 | 416 | 50366506 |
Hyper IgE syndrome | 21.06 | 10.29 | 17 | 238185 | 417 | 50366505 |
Blood alkaline phosphatase increased | 20.92 | 10.29 | 98 | 238104 | 37428 | 50329494 |
Hepatitis | 20.72 | 10.29 | 77 | 238125 | 31376 | 50335546 |
Myalgia | 20.63 | 10.29 | 437 | 237765 | 123882 | 50243040 |
Escherichia infection | 20.61 | 10.29 | 13 | 238189 | 10928 | 50355994 |
Treatment noncompliance | 20.40 | 10.29 | 73 | 238129 | 30077 | 50336845 |
Rib fracture | 20.40 | 10.29 | 37 | 238165 | 19184 | 50347738 |
Renal disorder | 20.39 | 10.29 | 64 | 238138 | 27441 | 50339481 |
Haemorrhage intracranial | 20.31 | 10.29 | 17 | 238185 | 12357 | 50354565 |
Exposure via body fluid | 20.23 | 10.29 | 17 | 238185 | 442 | 50366480 |
Restrictive pulmonary disease | 20.18 | 10.29 | 29 | 238173 | 1395 | 50365527 |
Ventricular tachycardia | 20.08 | 10.29 | 27 | 238175 | 15794 | 50351128 |
Myelodysplastic syndrome | 20.06 | 10.29 | 25 | 238177 | 15107 | 50351815 |
Chronic sinusitis | 19.92 | 10.29 | 69 | 238133 | 6076 | 50360846 |
Schizophreniform disorder | 19.73 | 10.29 | 9 | 238193 | 73 | 50366849 |
Pneumocystis jirovecii pneumonia | 19.67 | 10.29 | 24 | 238178 | 14639 | 50352283 |
Lethargy | 19.60 | 10.29 | 144 | 238058 | 49288 | 50317634 |
Ileus | 19.56 | 10.29 | 20 | 238182 | 13209 | 50353713 |
Adverse event | 19.55 | 10.29 | 302 | 237900 | 43461 | 50323461 |
Metastases to lung | 19.54 | 10.29 | 14 | 238188 | 11006 | 50355916 |
Dialysis | 19.52 | 10.29 | 10 | 238192 | 9428 | 50357494 |
Therapy interrupted | 19.47 | 10.29 | 41 | 238161 | 20111 | 50346811 |
Muscle rigidity | 19.47 | 10.29 | 11 | 238191 | 9818 | 50357104 |
Spinal fracture | 19.34 | 10.29 | 27 | 238175 | 15546 | 50351376 |
Klebsiella infection | 19.30 | 10.29 | 5 | 238197 | 7189 | 50359733 |
Surgery | 19.22 | 10.29 | 75 | 238127 | 30130 | 50336792 |
Retinitis | 19.19 | 10.29 | 33 | 238169 | 1854 | 50365068 |
Exposure during pregnancy | 19.06 | 10.29 | 723 | 237479 | 120292 | 50246630 |
Intestinal perforation | 18.99 | 10.29 | 13 | 238189 | 10466 | 50356456 |
Cholestasis | 18.90 | 10.29 | 59 | 238143 | 25342 | 50341580 |
Pregnancy on contraceptive | 18.83 | 10.29 | 24 | 238178 | 1028 | 50365894 |
Eye pruritus | 18.80 | 10.29 | 112 | 238090 | 12422 | 50354500 |
Gait inability | 18.75 | 10.29 | 100 | 238102 | 36927 | 50329995 |
Angina pectoris | 18.67 | 10.29 | 62 | 238140 | 26126 | 50340796 |
Obstructive airways disorder | 18.66 | 10.29 | 132 | 238070 | 15520 | 50351402 |
Neuroleptic malignant syndrome | 18.63 | 10.29 | 15 | 238187 | 11115 | 50355807 |
Drug level decreased | 18.59 | 10.29 | 4 | 238198 | 6529 | 50360393 |
Premature labour | 18.55 | 10.29 | 16 | 238186 | 11460 | 50355462 |
Hallucination, auditory | 18.54 | 10.29 | 14 | 238188 | 10714 | 50356208 |
Anaphylactoid reaction | 18.52 | 10.29 | 46 | 238156 | 3360 | 50363562 |
Skin laceration | 18.49 | 10.29 | 38 | 238164 | 18804 | 50348118 |
Ejection fraction decreased | 18.47 | 10.29 | 37 | 238165 | 18483 | 50348439 |
Blood pressure increased | 18.46 | 10.29 | 481 | 237721 | 132651 | 50234271 |
Histamine level increased | 18.46 | 10.29 | 6 | 238196 | 16 | 50366906 |
Urinary casts | 18.44 | 10.29 | 19 | 238183 | 644 | 50366278 |
Swelling face | 18.43 | 10.29 | 349 | 237853 | 52246 | 50314676 |
Lip pruritus | 18.37 | 10.29 | 20 | 238182 | 723 | 50366199 |
Seronegative arthritis | 18.34 | 10.29 | 34 | 238168 | 2027 | 50364895 |
Colitis ischaemic | 18.23 | 10.29 | 11 | 238191 | 9472 | 50357450 |
Iron deficiency anaemia | 18.23 | 10.29 | 32 | 238170 | 16802 | 50350120 |
Hyperpathia | 18.20 | 10.29 | 6 | 238196 | 17 | 50366905 |
Dislocation of vertebra | 18.19 | 10.29 | 43 | 238159 | 3044 | 50363878 |
Blood urea increased | 18.11 | 10.29 | 54 | 238148 | 23531 | 50343391 |
Insomnia | 18.04 | 10.29 | 1001 | 237201 | 173864 | 50193058 |
Low birth weight baby | 18.02 | 10.29 | 3 | 238199 | 5878 | 50361044 |
Renal injury | 17.99 | 10.29 | 9 | 238193 | 8602 | 50358320 |
Aphasia | 17.97 | 10.29 | 71 | 238131 | 28423 | 50338499 |
Hypervolaemia | 17.75 | 10.29 | 61 | 238141 | 25438 | 50341484 |
Toxic epidermal necrolysis | 17.65 | 10.29 | 46 | 238156 | 20946 | 50345976 |
Malaise | 17.64 | 10.29 | 1350 | 236852 | 334182 | 50032740 |
Seasonal allergy | 17.63 | 10.29 | 124 | 238078 | 14552 | 50352370 |
Hemiparesis | 17.58 | 10.29 | 43 | 238159 | 20005 | 50346917 |
Respiratory distress | 17.36 | 10.29 | 79 | 238123 | 30410 | 50336512 |
Menstruation delayed | 17.22 | 10.29 | 27 | 238175 | 1404 | 50365518 |
Intestinal obstruction | 17.11 | 10.29 | 65 | 238137 | 26318 | 50340604 |
Diffuse large B-cell lymphoma | 17.10 | 10.29 | 3 | 238199 | 5659 | 50361263 |
Bacterial test positive | 17.05 | 10.29 | 55 | 238147 | 4668 | 50362254 |
Magnesium deficiency | 17.02 | 10.29 | 16 | 238186 | 484 | 50366438 |
Eye swelling | 17.00 | 10.29 | 157 | 238045 | 19987 | 50346935 |
Blood potassium decreased | 16.97 | 10.29 | 103 | 238099 | 36842 | 50330080 |
Lymphocyte count decreased | 16.94 | 10.29 | 194 | 238008 | 26113 | 50340809 |
Acidosis | 16.85 | 10.29 | 14 | 238188 | 10213 | 50356709 |
Tooth disorder | 16.83 | 10.29 | 58 | 238144 | 24170 | 50342752 |
Lichen nitidus | 16.83 | 10.29 | 8 | 238194 | 72 | 50366850 |
Full blood count decreased | 16.56 | 10.29 | 52 | 238150 | 22294 | 50344628 |
Nasal turbinate hypertrophy | 16.51 | 10.29 | 18 | 238184 | 652 | 50366270 |
Bronchial haemorrhage | 16.49 | 10.29 | 16 | 238186 | 504 | 50366418 |
Eye infection bacterial | 16.41 | 10.29 | 9 | 238193 | 112 | 50366810 |
Ehlers-Danlos syndrome | 16.41 | 10.29 | 9 | 238193 | 112 | 50366810 |
Clostridium difficile infection | 16.29 | 10.29 | 63 | 238139 | 25376 | 50341546 |
Hypotonia | 16.26 | 10.29 | 9 | 238193 | 8125 | 50358797 |
Malnutrition | 16.25 | 10.29 | 23 | 238179 | 13166 | 50353756 |
Adverse drug reaction | 16.23 | 10.29 | 357 | 237845 | 54865 | 50312057 |
Lip swelling | 16.19 | 10.29 | 183 | 238019 | 24553 | 50342369 |
Erythema | 16.06 | 10.29 | 843 | 237359 | 145571 | 50221351 |
Tricuspid valve incompetence | 16 | 10.29 | 22 | 238180 | 12748 | 50354174 |
Failure to thrive | 15.98 | 10.29 | 5 | 238197 | 6353 | 50360569 |
Blood pressure decreased | 15.98 | 10.29 | 177 | 238025 | 55732 | 50311190 |
Deafness | 15.95 | 10.29 | 31 | 238171 | 15660 | 50351262 |
Diabetic ketoacidosis | 15.93 | 10.29 | 38 | 238164 | 17834 | 50349088 |
Humerus fracture | 15.86 | 10.29 | 8 | 238194 | 7610 | 50359312 |
Haemorrhoids | 15.83 | 10.29 | 42 | 238160 | 19011 | 50347911 |
White blood cell count increased | 15.82 | 10.29 | 125 | 238077 | 42115 | 50324807 |
Caesarean section | 15.81 | 10.29 | 31 | 238171 | 15608 | 50351314 |
Musculoskeletal stiffness | 15.80 | 10.29 | 748 | 237454 | 127733 | 50239189 |
Coronary artery disease | 15.77 | 10.29 | 79 | 238123 | 29647 | 50337275 |
Mouth ulceration | 15.73 | 10.29 | 73 | 238129 | 27951 | 50338971 |
Thymus disorder | 15.67 | 10.29 | 11 | 238191 | 217 | 50366705 |
Haemodialysis | 15.66 | 10.29 | 10 | 238192 | 8352 | 50358570 |
Urinary retention | 15.43 | 10.29 | 67 | 238135 | 26123 | 50340799 |
Oxygen saturation decreased | 15.42 | 10.29 | 247 | 237955 | 73001 | 50293921 |
Liver function test increased | 15.40 | 10.29 | 65 | 238137 | 25541 | 50341381 |
Femoral neck fracture | 15.39 | 10.29 | 8 | 238194 | 7482 | 50359440 |
Cardiac failure acute | 15.27 | 10.29 | 10 | 238192 | 8240 | 50358682 |
Delirium | 15.26 | 10.29 | 111 | 238091 | 38081 | 50328841 |
Hepatic steatosis | 15.22 | 10.29 | 61 | 238141 | 24323 | 50342599 |
Hypothyroidism | 15.22 | 10.29 | 96 | 238106 | 34029 | 50332893 |
Gastric haemorrhage | 15.20 | 10.29 | 4 | 238198 | 5692 | 50361230 |
Enteritis | 15.09 | 10.29 | 7 | 238195 | 6988 | 50359934 |
Device expulsion | 15.06 | 10.29 | 77 | 238125 | 28745 | 50338177 |
Mental disorder | 15.04 | 10.29 | 53 | 238149 | 21938 | 50344984 |
Encephalitis | 14.99 | 10.29 | 8 | 238194 | 7372 | 50359550 |
Bone density decreased | 14.99 | 10.29 | 18 | 238184 | 11057 | 50355865 |
Diverticulitis | 14.98 | 10.29 | 93 | 238109 | 33089 | 50333833 |
Ischaemic stroke | 14.95 | 10.29 | 33 | 238169 | 15915 | 50351007 |
Arrhythmia | 14.89 | 10.29 | 93 | 238109 | 33039 | 50333883 |
Drug withdrawal syndrome | 14.88 | 10.29 | 64 | 238138 | 25017 | 50341905 |
Lip dry | 14.87 | 10.29 | 53 | 238149 | 4734 | 50362188 |
Demyelination | 14.85 | 10.29 | 62 | 238140 | 5964 | 50360958 |
Dyskinesia | 14.81 | 10.29 | 74 | 238128 | 27787 | 50339135 |
Blood pressure systolic abnormal | 14.73 | 10.29 | 9 | 238193 | 7697 | 50359225 |
Suicide attempt | 14.69 | 10.29 | 164 | 238038 | 51568 | 50315354 |
Vision blurred | 14.69 | 10.29 | 271 | 237931 | 78376 | 50288546 |
Gastroenteritis | 14.69 | 10.29 | 58 | 238144 | 23223 | 50343699 |
Prevertebral soft tissue swelling of cervical space | 14.67 | 10.29 | 6 | 238196 | 36 | 50366886 |
Blood pressure systolic increased | 14.67 | 10.29 | 102 | 238100 | 35347 | 50331575 |
Eosinophilic granulomatosis with polyangiitis | 14.66 | 10.29 | 30 | 238172 | 1925 | 50364997 |
Diarrhoea haemorrhagic | 14.62 | 10.29 | 9 | 238193 | 7666 | 50359256 |
Tongue pruritus | 14.61 | 10.29 | 14 | 238188 | 434 | 50366488 |
Musculoskeletal disorder | 14.60 | 10.29 | 38 | 238164 | 17311 | 50349611 |
Candida infection | 14.59 | 10.29 | 59 | 238143 | 23464 | 50343458 |
Systemic inflammatory response syndrome | 14.56 | 10.29 | 3 | 238199 | 5046 | 50361876 |
Paraesthesia oral | 14.53 | 10.29 | 103 | 238099 | 12118 | 50354804 |
Osteoporosis | 14.50 | 10.29 | 138 | 238064 | 44741 | 50322181 |
Tenosynovitis | 14.49 | 10.29 | 17 | 238185 | 10548 | 50356374 |
Immune reconstitution inflammatory syndrome | 14.48 | 10.29 | 4 | 238198 | 5512 | 50361410 |
Haemodynamic instability | 14.48 | 10.29 | 10 | 238192 | 8014 | 50358908 |
Influenza like illness | 14.47 | 10.29 | 187 | 238015 | 57272 | 50309650 |
Heart rate irregular | 14.38 | 10.29 | 45 | 238157 | 19315 | 50347607 |
Respirovirus test positive | 14.27 | 10.29 | 5 | 238197 | 18 | 50366904 |
Cholecystitis chronic | 14.24 | 10.29 | 86 | 238116 | 9583 | 50357339 |
Diabetes mellitus inadequate control | 14.22 | 10.29 | 25 | 238177 | 13120 | 50353802 |
Oral pain | 14.17 | 10.29 | 65 | 238137 | 24968 | 50341954 |
Spinal pain | 14.16 | 10.29 | 18 | 238184 | 10785 | 50356137 |
Mitral valve incompetence | 14.15 | 10.29 | 39 | 238163 | 17432 | 50349490 |
Bone pain | 14.11 | 10.29 | 148 | 238054 | 47081 | 50319841 |
Lymphadenopathy | 14.05 | 10.29 | 96 | 238106 | 33403 | 50333519 |
Lung infiltration | 14.02 | 10.29 | 26 | 238176 | 13367 | 50353555 |
Right ventricular failure | 14.00 | 10.29 | 34 | 238168 | 15859 | 50351063 |
Paraesthesia | 14.00 | 10.29 | 445 | 237757 | 119798 | 50247124 |
Antinuclear antibody positive | 13.96 | 10.29 | 6 | 238196 | 6266 | 50360656 |
Eosinophil count increased | 13.95 | 10.29 | 80 | 238122 | 8750 | 50358172 |
Blood pressure diastolic decreased | 13.93 | 10.29 | 37 | 238165 | 16744 | 50350178 |
Joint effusion | 13.88 | 10.29 | 25 | 238177 | 12996 | 50353926 |
Breast cancer metastatic | 13.87 | 10.29 | 17 | 238185 | 10347 | 50356575 |
Electrocardiogram QRS complex prolonged | 13.80 | 10.29 | 4 | 238198 | 5340 | 50361582 |
Crepitations | 13.77 | 10.29 | 6 | 238196 | 6213 | 50360709 |
Hepatocellular injury | 13.74 | 10.29 | 69 | 238133 | 25878 | 50341044 |
Therapy non-responder | 13.62 | 10.29 | 164 | 238038 | 50858 | 50316064 |
Therapy partial responder | 13.60 | 10.29 | 7 | 238195 | 6584 | 50360338 |
Sopor | 13.54 | 10.29 | 48 | 238154 | 19831 | 50347091 |
Epidermolysis bullosa | 13.53 | 10.29 | 8 | 238194 | 116 | 50366806 |
Chills | 13.49 | 10.29 | 349 | 237853 | 96338 | 50270584 |
Device difficult to use | 13.46 | 10.29 | 16 | 238186 | 9870 | 50357052 |
Polymenorrhoea | 13.42 | 10.29 | 21 | 238181 | 1090 | 50365832 |
Chronic obstructive pulmonary disease | 13.42 | 10.29 | 174 | 238028 | 53261 | 50313661 |
Nasal oedema | 13.41 | 10.29 | 18 | 238184 | 812 | 50366110 |
Granulocytopenia | 13.35 | 10.29 | 4 | 238198 | 5227 | 50361695 |
Haematocrit decreased | 13.34 | 10.29 | 103 | 238099 | 34873 | 50332049 |
Osteoarthritis | 13.25 | 10.29 | 235 | 237967 | 68371 | 50298551 |
Gastric disorder | 13.24 | 10.29 | 83 | 238119 | 29465 | 50337457 |
Rash pustular | 13.20 | 10.29 | 7 | 238195 | 6474 | 50360448 |
Red blood cell count decreased | 13.20 | 10.29 | 99 | 238103 | 33736 | 50333186 |
Psoriatic arthropathy | 13.18 | 10.29 | 302 | 237900 | 46730 | 50320192 |
Monocyte count abnormal | 13.16 | 10.29 | 9 | 238193 | 170 | 50366752 |
Lacrimation increased | 13.13 | 10.29 | 130 | 238072 | 16862 | 50350060 |
Hyperplastic cholecystopathy | 13.06 | 10.29 | 7 | 238195 | 83 | 50366839 |
Faeces discoloured | 13.05 | 10.29 | 36 | 238166 | 16088 | 50350834 |
Ovarian cancer | 13.03 | 10.29 | 4 | 238198 | 5145 | 50361777 |
Abnormal behaviour | 13.03 | 10.29 | 48 | 238154 | 19610 | 50347312 |
Deep vein thrombosis postoperative | 13.02 | 10.29 | 26 | 238176 | 1639 | 50365283 |
Bronchial disorder | 12.99 | 10.29 | 21 | 238181 | 1121 | 50365801 |
Marginal zone lymphoma | 12.98 | 10.29 | 5 | 238197 | 25 | 50366897 |
Deep vein thrombosis | 12.95 | 10.29 | 255 | 237947 | 73049 | 50293873 |
Drug eruption | 12.95 | 10.29 | 62 | 238140 | 23544 | 50343378 |
Pulmonary toxicity | 12.90 | 10.29 | 5 | 238197 | 5557 | 50361365 |
Sudden death | 12.84 | 10.29 | 14 | 238188 | 8977 | 50357945 |
Incorrect dose administered | 12.78 | 10.29 | 156 | 238046 | 48258 | 50318664 |
Stillbirth | 12.77 | 10.29 | 6 | 238196 | 5946 | 50360976 |
Dementia | 12.74 | 10.29 | 36 | 238166 | 15961 | 50350961 |
Urine amphetamine positive | 12.72 | 10.29 | 6 | 238196 | 53 | 50366869 |
Unevaluable event | 12.71 | 10.29 | 147 | 238055 | 45919 | 50321003 |
Hallucination, visual | 12.70 | 10.29 | 38 | 238164 | 16544 | 50350378 |
Premenstrual syndrome | 12.63 | 10.29 | 15 | 238187 | 597 | 50366325 |
Hypernatraemia | 12.63 | 10.29 | 7 | 238195 | 6314 | 50360608 |
Anti-cyclic citrullinated peptide antibody | 12.62 | 10.29 | 25 | 238177 | 1567 | 50365355 |
Miosis | 12.59 | 10.29 | 7 | 238195 | 6303 | 50360619 |
Cells in urine | 12.55 | 10.29 | 9 | 238193 | 184 | 50366738 |
Anticipatory anxiety | 12.53 | 10.29 | 11 | 238191 | 304 | 50366618 |
Dyspnoea exertional | 12.44 | 10.29 | 168 | 238034 | 51065 | 50315857 |
Infusion site pain | 12.39 | 10.29 | 100 | 238102 | 12246 | 50354676 |
Torsade de pointes | 12.36 | 10.29 | 23 | 238179 | 11812 | 50355110 |
Prothrombin time prolonged | 12.36 | 10.29 | 14 | 238188 | 8824 | 50358098 |
Burns second degree | 12.35 | 10.29 | 16 | 238186 | 697 | 50366225 |
Heart rate decreased | 12.32 | 10.29 | 111 | 238091 | 36386 | 50330536 |
Troponin increased | 12.32 | 10.29 | 12 | 238190 | 8106 | 50358816 |
No adverse event | 12.28 | 10.29 | 100 | 238102 | 33478 | 50333444 |
Multiple fractures | 12.25 | 10.29 | 8 | 238194 | 6603 | 50360319 |
Food intolerance | 12.24 | 10.29 | 32 | 238170 | 2412 | 50364510 |
Ovarian germ cell cancer stage II | 12.23 | 10.29 | 5 | 238197 | 30 | 50366892 |
Myopathy | 12.22 | 10.29 | 15 | 238187 | 9124 | 50357798 |
Mechanical urticaria | 12.19 | 10.29 | 12 | 238190 | 385 | 50366537 |
Peripheral sensory neuropathy | 12.18 | 10.29 | 8 | 238194 | 6583 | 50360339 |
Venous thrombosis | 12.18 | 10.29 | 3 | 238199 | 4463 | 50362459 |
Autoimmune disorder | 12.18 | 10.29 | 58 | 238144 | 5902 | 50361020 |
Cardiovascular disorder | 12.13 | 10.29 | 19 | 238183 | 10435 | 50356487 |
Suspected suicide | 12.13 | 10.29 | 5 | 238197 | 5352 | 50361570 |
Sneezing | 12.12 | 10.29 | 110 | 238092 | 13934 | 50352988 |
Pallor | 12.11 | 10.29 | 62 | 238140 | 23137 | 50343785 |
Malignant melanoma | 12.09 | 10.29 | 18 | 238184 | 10090 | 50356832 |
Urine output decreased | 12.03 | 10.29 | 19 | 238183 | 10402 | 50356520 |
Hypothermia | 11.99 | 10.29 | 24 | 238178 | 11992 | 50354930 |
Blood pressure systolic decreased | 11.99 | 10.29 | 6 | 238196 | 5733 | 50361189 |
Bacterial infection | 11.98 | 10.29 | 38 | 238164 | 16243 | 50350679 |
Second primary malignancy | 11.98 | 10.29 | 9 | 238193 | 6905 | 50360017 |
Deficiency of bile secretion | 11.97 | 10.29 | 4 | 238198 | 12 | 50366910 |
Autophobia | 11.97 | 10.29 | 4 | 238198 | 12 | 50366910 |
Haemoglobin abnormal | 11.96 | 10.29 | 3 | 238199 | 4409 | 50362513 |
Spinal cord paralysis | 11.96 | 10.29 | 5 | 238197 | 32 | 50366890 |
Syphilis | 11.93 | 10.29 | 8 | 238194 | 146 | 50366776 |
Choluria | 11.89 | 10.29 | 8 | 238194 | 147 | 50366775 |
Metabolic disorder | 11.86 | 10.29 | 5 | 238197 | 5281 | 50361641 |
Metastasis | 11.82 | 10.29 | 3 | 238199 | 4372 | 50362550 |
Device use error | 11.78 | 10.29 | 5 | 238197 | 5261 | 50361661 |
Condition aggravated | 11.77 | 10.29 | 1583 | 236619 | 295475 | 50071447 |
Injection site haemorrhage | 11.75 | 10.29 | 56 | 238146 | 21290 | 50345632 |
Deformity | 11.74 | 10.29 | 12 | 238190 | 7928 | 50358994 |
Hepatic encephalopathy | 11.68 | 10.29 | 17 | 238185 | 9619 | 50357303 |
Poisoning deliberate | 11.65 | 10.29 | 12 | 238190 | 7900 | 50359022 |
Visual acuity reduced | 11.58 | 10.29 | 52 | 238150 | 20087 | 50346835 |
Lymphoma | 11.57 | 10.29 | 17 | 238185 | 9584 | 50357338 |
Vaginal haemorrhage | 11.51 | 10.29 | 68 | 238134 | 24483 | 50342439 |
Duodenal ulcer | 11.51 | 10.29 | 9 | 238193 | 6766 | 50360156 |
Oesophagitis | 11.50 | 10.29 | 29 | 238173 | 13354 | 50353568 |
Ventricular fibrillation | 11.50 | 10.29 | 20 | 238182 | 10539 | 50356383 |
Intestinal ischaemia | 11.45 | 10.29 | 9 | 238193 | 6748 | 50360174 |
Poisoning | 11.42 | 10.29 | 26 | 238176 | 12403 | 50354519 |
Burning sensation | 11.41 | 10.29 | 148 | 238054 | 45298 | 50321624 |
Endometrial ablation | 11.40 | 10.29 | 17 | 238185 | 846 | 50366076 |
Faecaloma | 11.38 | 10.29 | 10 | 238192 | 7098 | 50359824 |
Device malfunction | 11.34 | 10.29 | 35 | 238167 | 15086 | 50351836 |
Abdominal distension | 11.30 | 10.29 | 259 | 237943 | 72644 | 50294278 |
Fungal endocarditis | 11.28 | 10.29 | 9 | 238193 | 217 | 50366705 |
Underdose | 11.27 | 10.29 | 53 | 238149 | 20225 | 50346697 |
Brain oedema | 11.27 | 10.29 | 26 | 238176 | 12344 | 50354578 |
Lactose intolerance | 11.23 | 10.29 | 32 | 238170 | 2538 | 50364384 |
Tumour lysis syndrome | 11.22 | 10.29 | 11 | 238191 | 7410 | 50359512 |
Atelectasis | 11.22 | 10.29 | 46 | 238156 | 18224 | 50348698 |
Drug reaction with eosinophilia and systemic symptoms | 11.17 | 10.29 | 83 | 238119 | 28341 | 50338581 |
Schizophrenia | 11.15 | 10.29 | 11 | 238191 | 7386 | 50359536 |
Atopy | 11.14 | 10.29 | 9 | 238193 | 221 | 50366701 |
Coagulopathy | 11.13 | 10.29 | 45 | 238157 | 17899 | 50349023 |
Body temperature fluctuation | 11.10 | 10.29 | 27 | 238175 | 1946 | 50364976 |
Atrial flutter | 11.08 | 10.29 | 15 | 238187 | 8748 | 50358174 |
CSF volume increased | 11.03 | 10.29 | 3 | 238199 | 3 | 50366919 |
Epstein-Barr virus infection | 11.02 | 10.29 | 10 | 238192 | 6987 | 50359935 |
Ataxia | 10.99 | 10.29 | 31 | 238171 | 13755 | 50353167 |
Cyanosis central | 10.99 | 10.29 | 6 | 238196 | 74 | 50366848 |
Throat tightness | 10.95 | 10.29 | 148 | 238054 | 20699 | 50346223 |
Microcytosis | 10.89 | 10.29 | 8 | 238194 | 170 | 50366752 |
Urobilinogen urine increased | 10.87 | 10.29 | 9 | 238193 | 229 | 50366693 |
Amylase increased | 10.87 | 10.29 | 6 | 238196 | 5424 | 50361498 |
Colon cancer | 10.86 | 10.29 | 15 | 238187 | 8676 | 50358246 |
Atrioventricular block first degree | 10.84 | 10.29 | 8 | 238194 | 6193 | 50360729 |
Cholangitis | 10.82 | 10.29 | 4 | 238198 | 4575 | 50362347 |
Autoimmune arthritis | 10.81 | 10.29 | 5 | 238197 | 42 | 50366880 |
Splenomegaly | 10.79 | 10.29 | 18 | 238184 | 9642 | 50357280 |
Cyst | 10.79 | 10.29 | 26 | 238176 | 12161 | 50354761 |
Glycosylated haemoglobin increased | 10.74 | 10.29 | 21 | 238181 | 10585 | 50356337 |
Amino acid level decreased | 10.71 | 10.29 | 5 | 238197 | 43 | 50366879 |
Product administration error | 10.65 | 10.29 | 52 | 238150 | 19647 | 50347275 |
Device issue | 10.64 | 10.29 | 53 | 238149 | 19919 | 50347003 |
Pregnancy | 10.62 | 10.29 | 197 | 238005 | 29380 | 50337542 |
X-ray abnormal | 10.61 | 10.29 | 32 | 238170 | 2620 | 50364302 |
Post procedural infection | 10.59 | 10.29 | 12 | 238190 | 7564 | 50359358 |
Muscle atrophy | 10.56 | 10.29 | 8 | 238194 | 6113 | 50360809 |
Hyperbilirubinaemia | 10.54 | 10.29 | 18 | 238184 | 9552 | 50357370 |
Head injury | 10.49 | 10.29 | 68 | 238134 | 23952 | 50342970 |
Nitrite urine present | 10.48 | 10.29 | 17 | 238185 | 910 | 50366012 |
Protrusion tongue | 10.44 | 10.29 | 10 | 238192 | 310 | 50366612 |
Hydronephrosis | 10.42 | 10.29 | 15 | 238187 | 8526 | 50358396 |
Ankylosing spondylitis | 10.40 | 10.29 | 11 | 238191 | 7154 | 50359768 |
Dyshidrotic eczema | 10.40 | 10.29 | 13 | 238189 | 546 | 50366376 |
Blood albumin decreased | 10.38 | 10.29 | 30 | 238172 | 13206 | 50353716 |
Axillary pain | 10.37 | 10.29 | 23 | 238179 | 1561 | 50365361 |
Large intestine perforation | 10.34 | 10.29 | 12 | 238190 | 7482 | 50359440 |
Monocyte percentage increased | 10.32 | 10.29 | 18 | 238184 | 1023 | 50365899 |
Pharyngeal oedema | 10.31 | 10.29 | 101 | 238101 | 13064 | 50353858 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 269.31 | 10.56 | 318 | 52853 | 33531 | 29487825 |
Urticaria | 263.45 | 10.56 | 402 | 52769 | 54258 | 29467098 |
Pruritus | 174.31 | 10.56 | 533 | 52638 | 116316 | 29405040 |
Sleep terror | 107.75 | 10.56 | 43 | 53128 | 698 | 29520658 |
Sinusitis | 87.70 | 10.56 | 192 | 52979 | 34158 | 29487198 |
Dermatitis atopic | 80.43 | 10.56 | 50 | 53121 | 2169 | 29519187 |
Infective pulmonary exacerbation of cystic fibrosis | 76.90 | 10.56 | 74 | 53097 | 6162 | 29515194 |
Rash | 75.96 | 10.56 | 592 | 52579 | 189227 | 29332129 |
Death | 75.42 | 10.56 | 338 | 52833 | 341746 | 29179610 |
Forced expiratory volume decreased | 71.94 | 10.56 | 51 | 53120 | 2762 | 29518594 |
Wheezing | 67.60 | 10.56 | 170 | 53001 | 33070 | 29488286 |
Upper respiratory tract infection | 64.35 | 10.56 | 148 | 53023 | 27201 | 29494155 |
Vital capacity decreased | 63.37 | 10.56 | 24 | 53147 | 336 | 29521020 |
Hypersensitivity | 58.91 | 10.56 | 219 | 52952 | 52684 | 29468672 |
Headache | 53.94 | 10.56 | 513 | 52658 | 173494 | 29347862 |
Anaemia | 53.43 | 10.56 | 184 | 52987 | 200767 | 29320589 |
Cough | 48.26 | 10.56 | 391 | 52780 | 126336 | 29395020 |
Eczema | 46.88 | 10.56 | 87 | 53084 | 13739 | 29507617 |
Lip swelling | 45.78 | 10.56 | 81 | 53090 | 12329 | 29509027 |
Anaphylactic reaction | 43.05 | 10.56 | 128 | 53043 | 27445 | 29493911 |
Swelling face | 42.33 | 10.56 | 105 | 53066 | 20245 | 29501111 |
Potassium wasting nephropathy | 42.21 | 10.56 | 13 | 53158 | 92 | 29521264 |
Parathyroid gland enlargement | 39.48 | 10.56 | 13 | 53158 | 117 | 29521239 |
Migraine | 39.40 | 10.56 | 76 | 53095 | 12354 | 29509002 |
Sudden infant death syndrome | 38.99 | 10.56 | 14 | 53157 | 167 | 29521189 |
Mydriasis | 38.46 | 10.56 | 51 | 53120 | 6034 | 29515322 |
Upper respiratory fungal infection | 38.35 | 10.56 | 13 | 53158 | 129 | 29521227 |
Eye disorder | 38.19 | 10.56 | 58 | 53113 | 7776 | 29513580 |
Fatigue | 37.81 | 10.56 | 788 | 52383 | 316033 | 29205323 |
Angioedema | 36.24 | 10.56 | 133 | 53038 | 31782 | 29489574 |
Multiple organ dysfunction syndrome | 36.20 | 10.56 | 36 | 53135 | 63080 | 29458276 |
Suicidal ideation | 35.57 | 10.56 | 140 | 53031 | 34576 | 29486780 |
General physical health deterioration | 35.53 | 10.56 | 83 | 53088 | 102774 | 29418582 |
Chest discomfort | 35.30 | 10.56 | 170 | 53001 | 45813 | 29475543 |
Forced expiratory volume | 33.91 | 10.56 | 11 | 53160 | 94 | 29521262 |
Nasal congestion | 33.71 | 10.56 | 92 | 53079 | 18787 | 29502569 |
Crystal urine present | 33.29 | 10.56 | 16 | 53155 | 413 | 29520943 |
Blood pressure increased | 32.69 | 10.56 | 236 | 52935 | 73567 | 29447789 |
Renal failure | 32.55 | 10.56 | 107 | 53064 | 118492 | 29402864 |
Flushing | 32.23 | 10.56 | 120 | 53051 | 28872 | 29492484 |
Obstructive airways disorder | 32.07 | 10.56 | 65 | 53106 | 10951 | 29510405 |
Throat irritation | 31.96 | 10.56 | 57 | 53114 | 8728 | 29512628 |
Renal impairment | 31.10 | 10.56 | 62 | 53109 | 81271 | 29440085 |
Influenza | 30.83 | 10.56 | 153 | 53018 | 41728 | 29479628 |
Erythema | 30.78 | 10.56 | 237 | 52934 | 75369 | 29445987 |
Oral pruritus | 30.70 | 10.56 | 13 | 53158 | 247 | 29521109 |
Tendon disorder | 29.79 | 10.56 | 29 | 53142 | 2449 | 29518907 |
Interstitial lung disease | 29.70 | 10.56 | 36 | 53135 | 57682 | 29463674 |
Pulmonary function test decreased | 29.62 | 10.56 | 37 | 53134 | 4126 | 29517230 |
Product dose omission issue | 29.21 | 10.56 | 283 | 52888 | 96100 | 29425256 |
Nasal oedema | 28.83 | 10.56 | 13 | 53158 | 289 | 29521067 |
Completed suicide | 28.68 | 10.56 | 76 | 53095 | 90170 | 29431186 |
Toxicity to various agents | 28.49 | 10.56 | 189 | 52982 | 173472 | 29347884 |
Penile haemorrhage | 28.13 | 10.56 | 16 | 53155 | 588 | 29520768 |
Lower respiratory tract infection | 28.06 | 10.56 | 108 | 53063 | 26394 | 29494962 |
Differentiation syndrome | 28.05 | 10.56 | 20 | 53151 | 1093 | 29520263 |
Bronchopulmonary aspergillosis allergic | 27.62 | 10.56 | 15 | 53156 | 503 | 29520853 |
Anxiety | 27.54 | 10.56 | 254 | 52917 | 85111 | 29436245 |
Penis injury | 27.46 | 10.56 | 12 | 53159 | 247 | 29521109 |
Dry skin | 27.20 | 10.56 | 98 | 53073 | 23209 | 29498147 |
Anticholinergic syndrome | 27.10 | 10.56 | 18 | 53153 | 876 | 29520480 |
Depressed mood | 26.28 | 10.56 | 77 | 53094 | 16371 | 29504985 |
Myocardial infarction | 25.99 | 10.56 | 106 | 53065 | 110190 | 29411166 |
Throat tightness | 25.79 | 10.56 | 46 | 53125 | 7045 | 29514311 |
Cardiac failure | 25.78 | 10.56 | 66 | 53105 | 79221 | 29442135 |
Disturbance in attention | 25.78 | 10.56 | 91 | 53080 | 21333 | 29500023 |
Rash erythematous | 25.44 | 10.56 | 91 | 53080 | 21471 | 29499885 |
Ear infection | 23.83 | 10.56 | 48 | 53123 | 8052 | 29513304 |
Rash pruritic | 23.56 | 10.56 | 91 | 53080 | 22272 | 29499084 |
Anger | 23.50 | 10.56 | 57 | 53114 | 10833 | 29510523 |
Bone marrow failure | 23.40 | 10.56 | 10 | 53161 | 27439 | 29493917 |
Hyperleukocytosis | 23.23 | 10.56 | 21 | 53150 | 1614 | 29519742 |
Victim of chemical submission | 23.04 | 10.56 | 7 | 53164 | 47 | 29521309 |
Gastric ulcer perforation | 22.61 | 10.56 | 16 | 53155 | 864 | 29520492 |
Sinus disorder | 22.13 | 10.56 | 39 | 53132 | 5916 | 29515440 |
Malignant neoplasm progression | 22.12 | 10.56 | 64 | 53107 | 73795 | 29447561 |
Sepsis | 22.04 | 10.56 | 158 | 53013 | 142524 | 29378832 |
Ascites | 22.03 | 10.56 | 20 | 53151 | 36599 | 29484757 |
Drug resistance | 21.55 | 10.56 | 6 | 53165 | 21534 | 29499822 |
Mastocytosis | 21.24 | 10.56 | 6 | 53165 | 30 | 29521326 |
Swollen tongue | 21.13 | 10.56 | 59 | 53112 | 12207 | 29509149 |
Encephalopathy | 21.12 | 10.56 | 15 | 53156 | 31028 | 29490328 |
Disease progression | 21.04 | 10.56 | 76 | 53095 | 81840 | 29439516 |
Gastrointestinal haemorrhage | 20.96 | 10.56 | 73 | 53098 | 79460 | 29441896 |
Acute kidney injury | 20.70 | 10.56 | 344 | 52827 | 264923 | 29256433 |
Aspirin-exacerbated respiratory disease | 20.64 | 10.56 | 11 | 53160 | 355 | 29521001 |
Cerebral dysgenesis | 20.52 | 10.56 | 5 | 53166 | 12 | 29521344 |
Infusion related reaction | 19.80 | 10.56 | 141 | 53030 | 43745 | 29477611 |
Drug ineffective | 19.72 | 10.56 | 500 | 52671 | 362670 | 29158686 |
Malaise | 19.60 | 10.56 | 399 | 52772 | 159203 | 29362153 |
Postmortem blood drug level | 19.55 | 10.56 | 8 | 53163 | 139 | 29521217 |
Sinus congestion | 19.51 | 10.56 | 32 | 53139 | 4580 | 29516776 |
Lymphocyte percentage decreased | 19.51 | 10.56 | 21 | 53150 | 1996 | 29519360 |
Sensorimotor disorder | 19.50 | 10.56 | 11 | 53160 | 398 | 29520958 |
Middle insomnia | 19.45 | 10.56 | 36 | 53135 | 5672 | 29515684 |
Seizure | 19.36 | 10.56 | 254 | 52917 | 92869 | 29428487 |
Tic | 19.34 | 10.56 | 20 | 53151 | 1815 | 29519541 |
Mood altered | 19.18 | 10.56 | 44 | 53127 | 8067 | 29513289 |
Poverty of speech | 19.06 | 10.56 | 9 | 53162 | 223 | 29521133 |
Rhinorrhoea | 19.06 | 10.56 | 83 | 53088 | 21436 | 29499920 |
Respiratory muscle weakness | 18.95 | 10.56 | 7 | 53164 | 91 | 29521265 |
Rheumatoid arthritis | 18.82 | 10.56 | 18 | 53153 | 32134 | 29489222 |
Off label use | 18.57 | 10.56 | 406 | 52765 | 300394 | 29220962 |
Seasonal allergy | 18.43 | 10.56 | 33 | 53138 | 5069 | 29516287 |
Nasal polyps | 18.14 | 10.56 | 19 | 53152 | 1750 | 29519606 |
Cardiogenic shock | 18.01 | 10.56 | 6 | 53165 | 19184 | 29502172 |
Blister | 17.80 | 10.56 | 77 | 53094 | 19829 | 29501527 |
Dry eye | 17.72 | 10.56 | 40 | 53131 | 7256 | 29514100 |
Oral allergy syndrome | 17.70 | 10.56 | 5 | 53166 | 25 | 29521331 |
Infusion site pain | 17.70 | 10.56 | 24 | 53147 | 2901 | 29518455 |
International normalised ratio increased | 17.67 | 10.56 | 33 | 53138 | 44339 | 29477017 |
Platelet count decreased | 17.61 | 10.56 | 113 | 53058 | 104559 | 29416797 |
Disseminated intravascular coagulation | 17.48 | 10.56 | 7 | 53164 | 19973 | 29501383 |
Accidental overdose | 17.25 | 10.56 | 70 | 53101 | 17523 | 29503833 |
Dystonia | 16.90 | 10.56 | 47 | 53124 | 9702 | 29511654 |
Drug interaction | 16.71 | 10.56 | 252 | 52919 | 197133 | 29324223 |
Cerebral infarction | 16.68 | 10.56 | 12 | 53159 | 24663 | 29496693 |
Eosinophilic oesophagitis | 16.49 | 10.56 | 8 | 53163 | 211 | 29521145 |
Bronchospasm | 16.33 | 10.56 | 46 | 53125 | 9563 | 29511793 |
Neutrophil percentage increased | 16.28 | 10.56 | 18 | 53153 | 1763 | 29519593 |
Fixed eruption | 16.23 | 10.56 | 15 | 53156 | 1187 | 29520169 |
Specific gravity urine increased | 16.20 | 10.56 | 7 | 53164 | 140 | 29521216 |
Product quality issue | 16.19 | 10.56 | 64 | 53107 | 15831 | 29505525 |
Pancytopenia | 16.00 | 10.56 | 86 | 53085 | 83082 | 29438274 |
Urine analysis abnormal | 15.96 | 10.56 | 18 | 53153 | 1802 | 29519554 |
Cardio-respiratory arrest | 15.77 | 10.56 | 43 | 53128 | 50558 | 29470798 |
Cardiac arrest | 15.65 | 10.56 | 90 | 53081 | 85501 | 29435855 |
Illness | 15.56 | 10.56 | 36 | 53135 | 6638 | 29514718 |
Pleural effusion | 15.17 | 10.56 | 72 | 53099 | 71836 | 29449520 |
Skin haemorrhage | 15.07 | 10.56 | 25 | 53146 | 3612 | 29517744 |
Micropenis | 14.99 | 10.56 | 5 | 53166 | 47 | 29521309 |
Rash macular | 14.96 | 10.56 | 47 | 53124 | 10378 | 29510978 |
Hepatic function abnormal | 14.93 | 10.56 | 30 | 53141 | 39229 | 29482127 |
Palpitations | 14.85 | 10.56 | 105 | 53066 | 32499 | 29488857 |
Aggression | 14.78 | 10.56 | 112 | 53059 | 35429 | 29485927 |
Bronchial disorder | 14.73 | 10.56 | 14 | 53157 | 1147 | 29520209 |
Increased upper airway secretion | 14.62 | 10.56 | 16 | 53155 | 1550 | 29519806 |
Lymphocyte count decreased | 14.60 | 10.56 | 71 | 53100 | 19200 | 29502156 |
Conjunctivitis | 14.30 | 10.56 | 39 | 53132 | 7959 | 29513397 |
Dermatitis exfoliative | 14.26 | 10.56 | 34 | 53137 | 6391 | 29514965 |
C-reactive protein increased | 14.26 | 10.56 | 37 | 53134 | 44226 | 29477130 |
Heart rate increased | 14.16 | 10.56 | 119 | 53052 | 38819 | 29482537 |
Haemoglobin urine present | 14.13 | 10.56 | 5 | 53166 | 57 | 29521299 |
Brugada syndrome | 14.09 | 10.56 | 11 | 53160 | 690 | 29520666 |
Injection site swelling | 14.02 | 10.56 | 43 | 53128 | 9374 | 29511982 |
Reflux nephropathy | 13.97 | 10.56 | 5 | 53166 | 59 | 29521297 |
Amino acid level decreased | 13.90 | 10.56 | 5 | 53166 | 60 | 29521296 |
Abdominoplasty | 13.90 | 10.56 | 3 | 53168 | 3 | 29521353 |
Blood creatine phosphokinase increased | 13.85 | 10.56 | 33 | 53138 | 40611 | 29480745 |
Sinus operation | 13.82 | 10.56 | 10 | 53161 | 559 | 29520797 |
Oropharyngeal pain | 13.74 | 10.56 | 95 | 53076 | 29190 | 29492166 |
Rhinitis | 13.68 | 10.56 | 28 | 53143 | 4750 | 29516606 |
Myocardial oedema | 13.60 | 10.56 | 7 | 53164 | 210 | 29521146 |
Pseudoporphyria | 13.57 | 10.56 | 8 | 53163 | 315 | 29521041 |
Sleep apnoea syndrome | 13.45 | 10.56 | 65 | 53106 | 17534 | 29503822 |
Hereditary angioedema | 13.30 | 10.56 | 11 | 53160 | 750 | 29520606 |
Chronic spontaneous urticaria | 13.14 | 10.56 | 5 | 53166 | 71 | 29521285 |
Leukopenia | 13.02 | 10.56 | 53 | 53118 | 55150 | 29466206 |
Myelosuppression | 13.01 | 10.56 | 3 | 53168 | 12224 | 29509132 |
Septic shock | 12.98 | 10.56 | 63 | 53108 | 62497 | 29458859 |
Insomnia | 12.98 | 10.56 | 228 | 52943 | 88533 | 29432823 |
Respiratory failure | 12.92 | 10.56 | 112 | 53059 | 97019 | 29424337 |
Amino acid level increased | 12.70 | 10.56 | 8 | 53163 | 355 | 29521001 |
Crying | 12.62 | 10.56 | 29 | 53142 | 5322 | 29516034 |
Periorbital discomfort | 12.56 | 10.56 | 4 | 53167 | 32 | 29521324 |
Shock | 12.51 | 10.56 | 12 | 53159 | 21392 | 29499964 |
Secretion discharge | 12.44 | 10.56 | 25 | 53146 | 4185 | 29517171 |
Infusion site mass | 12.44 | 10.56 | 7 | 53164 | 252 | 29521104 |
Swelling | 12.40 | 10.56 | 107 | 53064 | 35176 | 29486180 |
Irritability | 12.31 | 10.56 | 75 | 53096 | 22077 | 29499279 |
Adenocarcinoma pancreas | 12.23 | 10.56 | 13 | 53158 | 1218 | 29520138 |
Gastroenteritis viral | 12.23 | 10.56 | 30 | 53141 | 5742 | 29515614 |
Eye movement disorder | 12.21 | 10.56 | 23 | 53148 | 3673 | 29517683 |
Erythema multiforme | 12.20 | 10.56 | 36 | 53135 | 7681 | 29513675 |
Urine ketone body present | 12.10 | 10.56 | 12 | 53159 | 1036 | 29520320 |
Penile erythema | 12.10 | 10.56 | 6 | 53165 | 166 | 29521190 |
Urethritis noninfective | 12.09 | 10.56 | 3 | 53168 | 8 | 29521348 |
Neuroleptic malignant syndrome | 12.08 | 10.56 | 7 | 53164 | 16141 | 29505215 |
Hypercapnic coma | 12.07 | 10.56 | 6 | 53165 | 167 | 29521189 |
Pruritus genital | 12.01 | 10.56 | 9 | 53162 | 531 | 29520825 |
Temperature intolerance | 12.00 | 10.56 | 20 | 53151 | 2901 | 29518455 |
Phonophobia | 11.97 | 10.56 | 6 | 53165 | 170 | 29521186 |
Urine abnormality | 11.96 | 10.56 | 15 | 53156 | 1679 | 29519677 |
Cerebral haemorrhage | 11.96 | 10.56 | 24 | 53147 | 31402 | 29489954 |
Full blood count abnormal | 11.87 | 10.56 | 56 | 53115 | 14957 | 29506399 |
Aplastic anaemia | 11.84 | 10.56 | 35 | 53136 | 7475 | 29513881 |
Drug-induced liver injury | 11.83 | 10.56 | 73 | 53098 | 21582 | 29499774 |
Urine albumin/creatinine ratio | 11.83 | 10.56 | 3 | 53168 | 9 | 29521347 |
Treatment failure | 11.81 | 10.56 | 31 | 53140 | 36908 | 29484448 |
Psychomotor hyperactivity | 11.76 | 10.56 | 37 | 53134 | 8176 | 29513180 |
Congenital genital malformation | 11.71 | 10.56 | 5 | 53166 | 97 | 29521259 |
Peritonitis | 11.71 | 10.56 | 6 | 53165 | 14818 | 29506538 |
Scratch | 11.69 | 10.56 | 19 | 53152 | 2699 | 29518657 |
Neutropenia | 11.53 | 10.56 | 167 | 53004 | 131544 | 29389812 |
Tonsillitis | 11.51 | 10.56 | 16 | 53155 | 1979 | 29519377 |
Respiratory tract infection | 11.38 | 10.56 | 57 | 53114 | 15594 | 29505762 |
Ocular hyperaemia | 11.18 | 10.56 | 39 | 53132 | 9088 | 29512268 |
Oculogyric crisis | 11.16 | 10.56 | 13 | 53158 | 1348 | 29520008 |
Ileus | 11.12 | 10.56 | 6 | 53165 | 14396 | 29506960 |
Haematochezia | 11.10 | 10.56 | 32 | 53139 | 36951 | 29484405 |
Pharyngitis streptococcal | 11.09 | 10.56 | 16 | 53155 | 2048 | 29519308 |
Accident | 11.02 | 10.56 | 22 | 53149 | 3666 | 29517690 |
Febrile neutropenia | 11.02 | 10.56 | 139 | 53032 | 112101 | 29409255 |
Affective disorder | 11.01 | 10.56 | 20 | 53151 | 3106 | 29518250 |
Pharyngeal paraesthesia | 10.98 | 10.56 | 8 | 53163 | 452 | 29520904 |
Genital haemorrhage | 10.97 | 10.56 | 5 | 53166 | 114 | 29521242 |
Post-tussive vomiting | 10.97 | 10.56 | 3 | 53168 | 13 | 29521343 |
Mycobacterial infection | 10.88 | 10.56 | 15 | 53156 | 1841 | 29519515 |
Hyperventilation | 10.83 | 10.56 | 17 | 53154 | 2345 | 29519011 |
Fibromyalgia | 10.80 | 10.56 | 18 | 53153 | 2611 | 29518745 |
Infusion site swelling | 10.80 | 10.56 | 15 | 53156 | 1855 | 29519501 |
Poor quality sleep | 10.74 | 10.56 | 33 | 53138 | 7200 | 29514156 |
Hypertrichosis | 10.64 | 10.56 | 7 | 53164 | 335 | 29521021 |
Physiotherapy chest | 10.62 | 10.56 | 3 | 53168 | 15 | 29521341 |
Eye swelling | 10.61 | 10.56 | 37 | 53134 | 8620 | 29512736 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pemphigus | 1439.89 | 9.88 | 1361 | 213395 | 59340 | 64224636 |
Systemic lupus erythematosus | 1269.57 | 9.88 | 1425 | 213331 | 76187 | 64207789 |
Glossodynia | 1265.82 | 9.88 | 1306 | 213450 | 63390 | 64220586 |
Hand deformity | 1119.10 | 9.88 | 1206 | 213550 | 61565 | 64222411 |
Pericarditis | 927.95 | 9.88 | 1092 | 213664 | 61424 | 64222552 |
Anti-cyclic citrullinated peptide antibody positive | 905.75 | 9.88 | 965 | 213791 | 48597 | 64235379 |
Hypersensitivity | 890.23 | 9.88 | 1997 | 212759 | 194455 | 64089521 |
Wound | 860.06 | 9.88 | 1163 | 213593 | 75314 | 64208662 |
Swelling | 838.59 | 9.88 | 1727 | 213029 | 158491 | 64125485 |
Urticaria | 819.79 | 9.88 | 1629 | 213127 | 145688 | 64138288 |
Alopecia | 760.06 | 9.88 | 1693 | 213063 | 163997 | 64119979 |
Discomfort | 717.49 | 9.88 | 1099 | 213657 | 79779 | 64204197 |
Pruritus | 701.54 | 9.88 | 2459 | 212297 | 309941 | 63974035 |
Abdominal discomfort | 694.91 | 9.88 | 1733 | 213023 | 180589 | 64103387 |
Duodenal ulcer perforation | 619.82 | 9.88 | 667 | 214089 | 33958 | 64250018 |
Helicobacter infection | 578.83 | 9.88 | 676 | 214080 | 37686 | 64246290 |
Synovitis | 569.26 | 9.88 | 1111 | 213645 | 97979 | 64185997 |
Arthropathy | 558.78 | 9.88 | 1240 | 213516 | 119727 | 64164249 |
Blister | 546.58 | 9.88 | 973 | 213783 | 79994 | 64203982 |
Muscle injury | 546.29 | 9.88 | 550 | 214206 | 25887 | 64258089 |
Contraindicated product administered | 539.91 | 9.88 | 1142 | 213614 | 106687 | 64177289 |
Folliculitis | 530.63 | 9.88 | 575 | 214181 | 29502 | 64254474 |
Irritable bowel syndrome | 508.79 | 9.88 | 625 | 214131 | 36744 | 64247232 |
Sinusitis | 499.85 | 9.88 | 1333 | 213423 | 144595 | 64139381 |
Hepatic enzyme increased | 494.52 | 9.88 | 1235 | 213521 | 128708 | 64155268 |
Sleep disorder due to general medical condition, insomnia type | 489.48 | 9.88 | 517 | 214239 | 25753 | 64258223 |
Maternal exposure during pregnancy | 486.36 | 9.88 | 1021 | 213735 | 94863 | 64189113 |
Infusion related reaction | 475.75 | 9.88 | 1413 | 213343 | 163054 | 64120922 |
Rash | 473.05 | 9.88 | 2871 | 211885 | 455678 | 63828298 |
Lower respiratory tract infection | 419.01 | 9.88 | 954 | 213802 | 93660 | 64190316 |
Death | 411.51 | 9.88 | 607 | 214149 | 482098 | 63801878 |
Asthma | 410.49 | 9.88 | 950 | 213806 | 94275 | 64189701 |
Rheumatoid factor positive | 388.93 | 9.88 | 529 | 214227 | 34409 | 64249567 |
Pain | 384.92 | 9.88 | 3149 | 211607 | 550362 | 63733614 |
Acute kidney injury | 357.91 | 9.88 | 591 | 214165 | 448649 | 63835327 |
Joint swelling | 349.57 | 9.88 | 1532 | 213224 | 213850 | 64070126 |
Toxicity to various agents | 343.06 | 9.88 | 424 | 214332 | 363089 | 63920887 |
Anaemia | 337.52 | 9.88 | 461 | 214295 | 378219 | 63905757 |
Drug intolerance | 331.95 | 9.88 | 1372 | 213384 | 186620 | 64097356 |
Completed suicide | 280.37 | 9.88 | 203 | 214553 | 224211 | 64059765 |
Drug interaction | 279.27 | 9.88 | 486 | 214270 | 361597 | 63922379 |
Fatigue | 273.21 | 9.88 | 3739 | 211017 | 744991 | 63538985 |
Therapeutic product effect decreased | 265.78 | 9.88 | 917 | 213839 | 114434 | 64169542 |
Impaired healing | 264.55 | 9.88 | 607 | 214149 | 59866 | 64224110 |
Ill-defined disorder | 262.62 | 9.88 | 502 | 214254 | 43550 | 64240426 |
Food allergy | 255.86 | 9.88 | 211 | 214545 | 7640 | 64276336 |
Neutropenia | 189.72 | 9.88 | 316 | 214440 | 239308 | 64044668 |
Temperature regulation disorder | 184.79 | 9.88 | 135 | 214621 | 4076 | 64279900 |
Hip arthroplasty | 175.03 | 9.88 | 280 | 214476 | 21071 | 64262905 |
Gastrointestinal disorder | 174.34 | 9.88 | 675 | 214081 | 89034 | 64194942 |
Product use issue | 172.47 | 9.88 | 976 | 213780 | 150739 | 64133237 |
Sepsis | 166.83 | 9.88 | 321 | 214435 | 230020 | 64053956 |
Hypotension | 164.71 | 9.88 | 681 | 214075 | 380293 | 63903683 |
Rheumatic fever | 164.42 | 9.88 | 178 | 214578 | 9116 | 64274860 |
Thrombocytopenia | 161.98 | 9.88 | 312 | 214444 | 223489 | 64060487 |
Knee arthroplasty | 157.61 | 9.88 | 305 | 214451 | 26694 | 64257282 |
Coeliac disease | 154.53 | 9.88 | 155 | 214601 | 7257 | 64276719 |
Pneumonia | 151.34 | 9.88 | 1167 | 213589 | 558409 | 63725567 |
Stomatitis | 149.09 | 9.88 | 741 | 214015 | 108864 | 64175112 |
Myocardial infarction | 146.29 | 9.88 | 203 | 214553 | 165618 | 64118358 |
Fall | 145.74 | 9.88 | 804 | 213952 | 416022 | 63867954 |
Headache | 145.35 | 9.88 | 2522 | 212234 | 526945 | 63757031 |
Wheezing | 141.11 | 9.88 | 587 | 214169 | 79992 | 64203984 |
Febrile neutropenia | 139.82 | 9.88 | 257 | 214499 | 187400 | 64096576 |
Renal impairment | 138.45 | 9.88 | 147 | 214609 | 134870 | 64149106 |
Multiple organ dysfunction syndrome | 138.35 | 9.88 | 83 | 214673 | 101330 | 64182646 |
Contusion | 138.05 | 9.88 | 746 | 214010 | 113219 | 64170757 |
Swollen joint count increased | 137.31 | 9.88 | 148 | 214608 | 7541 | 64276435 |
Malignant neoplasm progression | 133.31 | 9.88 | 108 | 214648 | 112763 | 64171213 |
Cardiac failure | 131.44 | 9.88 | 148 | 214608 | 132225 | 64151751 |
Angioedema | 129.05 | 9.88 | 476 | 214280 | 61345 | 64222631 |
Renal failure | 127.37 | 9.88 | 258 | 214498 | 181430 | 64102546 |
Pancytopenia | 125.84 | 9.88 | 176 | 214580 | 143133 | 64140843 |
Nasopharyngitis | 124.08 | 9.88 | 1094 | 213662 | 194979 | 64088997 |
Cardio-respiratory arrest | 122.76 | 9.88 | 89 | 214667 | 98304 | 64185672 |
Gastrointestinal haemorrhage | 120.72 | 9.88 | 158 | 214598 | 132154 | 64151822 |
Septic shock | 119.47 | 9.88 | 105 | 214651 | 105332 | 64178644 |
Peripheral swelling | 113.82 | 9.88 | 1130 | 213626 | 208023 | 64075953 |
Interstitial lung disease | 112.34 | 9.88 | 96 | 214660 | 97636 | 64186340 |
Weight increased | 110.97 | 9.88 | 1142 | 213614 | 212206 | 64071770 |
Crystal urine present | 108.44 | 9.88 | 72 | 214684 | 1857 | 64282119 |
Respiratory failure | 102.14 | 9.88 | 242 | 214514 | 160941 | 64123035 |
International normalised ratio increased | 100.87 | 9.88 | 70 | 214686 | 79097 | 64204879 |
Disease progression | 100.29 | 9.88 | 200 | 214556 | 141480 | 64142496 |
Hyponatraemia | 99.44 | 9.88 | 216 | 214540 | 148123 | 64135853 |
Blood creatinine increased | 98.43 | 9.88 | 189 | 214567 | 135593 | 64148383 |
Anaphylactic reaction | 97.47 | 9.88 | 470 | 214286 | 68194 | 64215782 |
Infective pulmonary exacerbation of cystic fibrosis | 97.09 | 9.88 | 155 | 214601 | 11641 | 64272335 |
Cardiac arrest | 96.28 | 9.88 | 233 | 214523 | 153831 | 64130145 |
Rhabdomyolysis | 96.12 | 9.88 | 98 | 214658 | 91628 | 64192348 |
Platelet count decreased | 94.61 | 9.88 | 267 | 214489 | 167444 | 64116532 |
Ear pain | 94.49 | 9.88 | 238 | 214518 | 24898 | 64259078 |
Metabolic acidosis | 91.39 | 9.88 | 62 | 214694 | 70896 | 64213080 |
Rash erythematous | 89.64 | 9.88 | 360 | 214396 | 48273 | 64235703 |
Cardiac failure congestive | 89.30 | 9.88 | 188 | 214568 | 130392 | 64153584 |
Swelling face | 88.35 | 9.88 | 411 | 214345 | 58755 | 64225221 |
Bone marrow failure | 88.35 | 9.88 | 25 | 214731 | 47927 | 64236049 |
Haemoglobin decreased | 84.55 | 9.88 | 348 | 214408 | 194715 | 64089261 |
Leukopenia | 83.33 | 9.88 | 130 | 214626 | 101112 | 64182864 |
Drug resistance | 82.32 | 9.88 | 10 | 214746 | 35092 | 64248884 |
Electric shock | 80.58 | 9.88 | 49 | 214707 | 1080 | 64282896 |
Muscle spasticity | 79.21 | 9.88 | 173 | 214583 | 16496 | 64267480 |
Hepatic function abnormal | 79.14 | 9.88 | 59 | 214697 | 64254 | 64219722 |
Urinary sediment present | 79.04 | 9.88 | 63 | 214693 | 2171 | 64281805 |
Throat irritation | 78.71 | 9.88 | 264 | 214492 | 32447 | 64251529 |
Immunodeficiency | 78.52 | 9.88 | 169 | 214587 | 15955 | 64268021 |
Type 2 diabetes mellitus | 76.99 | 9.88 | 269 | 214487 | 33751 | 64250225 |
Urine abnormality | 76.69 | 9.88 | 108 | 214648 | 7254 | 64276722 |
Atrial fibrillation | 74.91 | 9.88 | 304 | 214452 | 170785 | 64113191 |
White blood cells urine positive | 74.59 | 9.88 | 91 | 214665 | 5307 | 64278669 |
Lymphocyte percentage decreased | 73.56 | 9.88 | 84 | 214672 | 4565 | 64279411 |
Haemoglobin urine present | 73.53 | 9.88 | 42 | 214714 | 821 | 64283155 |
Depressed level of consciousness | 73.49 | 9.88 | 98 | 214658 | 81338 | 64202638 |
Dermatitis atopic | 71.67 | 9.88 | 76 | 214680 | 3800 | 64280176 |
Infection | 71.21 | 9.88 | 934 | 213822 | 183946 | 64100030 |
Diarrhoea | 70.40 | 9.88 | 1851 | 212905 | 720853 | 63563123 |
Night sweats | 69.79 | 9.88 | 271 | 214485 | 35775 | 64248201 |
Hypoglycaemia | 69.70 | 9.88 | 120 | 214636 | 89772 | 64194204 |
Respiratory disorder | 69.52 | 9.88 | 271 | 214485 | 35840 | 64248136 |
Arthralgia | 69.30 | 9.88 | 1945 | 212811 | 440315 | 63843661 |
Forced expiratory volume decreased | 68.97 | 9.88 | 99 | 214657 | 6768 | 64277208 |
Hyperkalaemia | 68.80 | 9.88 | 146 | 214610 | 100983 | 64182993 |
Pleural effusion | 68.79 | 9.88 | 205 | 214551 | 126354 | 64157622 |
Erythema | 68.31 | 9.88 | 936 | 213820 | 186134 | 64097842 |
Sleep terror | 68.07 | 9.88 | 45 | 214711 | 1152 | 64282824 |
Type I hypersensitivity | 67.72 | 9.88 | 71 | 214685 | 3503 | 64280473 |
Temperature intolerance | 65.93 | 9.88 | 107 | 214649 | 8148 | 64275828 |
Treatment failure | 65.35 | 9.88 | 635 | 214121 | 116181 | 64167795 |
Shock | 64.99 | 9.88 | 23 | 214733 | 38217 | 64245759 |
Pneumonia aspiration | 64.77 | 9.88 | 61 | 214695 | 59210 | 64224766 |
Ascites | 64.09 | 9.88 | 67 | 214689 | 61934 | 64222042 |
Respiratory arrest | 62.16 | 9.88 | 51 | 214705 | 52934 | 64231042 |
Blood creatine phosphokinase increased | 61.98 | 9.88 | 62 | 214694 | 58496 | 64225480 |
Drug abuse | 61.92 | 9.88 | 229 | 214527 | 132145 | 64151831 |
Neurotoxicity | 61.41 | 9.88 | 9 | 214747 | 27395 | 64256581 |
Neutrophil percentage increased | 59.91 | 9.88 | 74 | 214682 | 4371 | 64279605 |
Cytomegalovirus infection | 58.88 | 9.88 | 25 | 214731 | 37174 | 64246802 |
Red blood cells urine positive | 57.87 | 9.88 | 73 | 214683 | 4405 | 64279571 |
Haemorrhage | 57.00 | 9.88 | 111 | 214645 | 79240 | 64204736 |
Bursitis | 56.74 | 9.88 | 179 | 214577 | 21306 | 64262670 |
Haematuria | 56.38 | 9.88 | 71 | 214685 | 60400 | 64223576 |
Urine analysis abnormal | 56.37 | 9.88 | 82 | 214674 | 5674 | 64278302 |
Lactic acidosis | 56.32 | 9.88 | 73 | 214683 | 61337 | 64222639 |
Lip swelling | 56.26 | 9.88 | 233 | 214523 | 31674 | 64252302 |
Disseminated intravascular coagulation | 55.76 | 9.88 | 19 | 214737 | 32329 | 64251647 |
Encephalopathy | 54.90 | 9.88 | 69 | 214687 | 58750 | 64225226 |
Blood cholesterol increased | 54.78 | 9.88 | 319 | 214437 | 49747 | 64234229 |
Eczema | 53.96 | 9.88 | 219 | 214537 | 29501 | 64254475 |
Oral pruritus | 53.63 | 9.88 | 46 | 214710 | 1759 | 64282217 |
Cerebrovascular accident | 52.65 | 9.88 | 257 | 214499 | 137326 | 64146650 |
Urine leukocyte esterase positive | 51.35 | 9.88 | 60 | 214696 | 3343 | 64280633 |
Body temperature increased | 51.31 | 9.88 | 250 | 214506 | 36416 | 64247560 |
Acute myeloid leukaemia | 51.18 | 9.88 | 14 | 214742 | 27449 | 64256527 |
Cardiogenic shock | 50.99 | 9.88 | 22 | 214734 | 32405 | 64251571 |
Chest discomfort | 50.88 | 9.88 | 601 | 214155 | 115505 | 64168471 |
Hereditary angioedema | 49.80 | 9.88 | 63 | 214693 | 3813 | 64280163 |
Melaena | 48.75 | 9.88 | 64 | 214692 | 53484 | 64230492 |
Hepatic failure | 48.62 | 9.88 | 68 | 214688 | 55326 | 64228650 |
Upper respiratory tract infection | 48.51 | 9.88 | 411 | 214345 | 72374 | 64211602 |
Acute myocardial infarction | 47.96 | 9.88 | 100 | 214656 | 69618 | 64214358 |
Coma | 47.54 | 9.88 | 142 | 214614 | 87473 | 64196503 |
Dehydration | 47.33 | 9.88 | 477 | 214279 | 216286 | 64067690 |
Serotonin syndrome | 47.09 | 9.88 | 37 | 214719 | 39245 | 64244731 |
Blood immunoglobulin E increased | 47.06 | 9.88 | 61 | 214695 | 3783 | 64280193 |
Overdose | 46.66 | 9.88 | 325 | 214431 | 159241 | 64124735 |
Insomnia | 46.57 | 9.88 | 921 | 213835 | 196915 | 64087061 |
Post-traumatic stress disorder | 45.76 | 9.88 | 63 | 214693 | 4142 | 64279834 |
Obstructive airways disorder | 45.44 | 9.88 | 175 | 214581 | 23010 | 64260966 |
Hypercalcaemia | 45.29 | 9.88 | 24 | 214732 | 31392 | 64252584 |
Altered state of consciousness | 45.06 | 9.88 | 36 | 214720 | 37866 | 64246110 |
Off label use | 44.93 | 9.88 | 1689 | 213067 | 631117 | 63652859 |
Myelosuppression | 44.69 | 9.88 | 12 | 214744 | 23818 | 64260158 |
Blood bilirubin increased | 44.46 | 9.88 | 77 | 214679 | 57476 | 64226500 |
Mastocytosis | 44.17 | 9.88 | 24 | 214732 | 424 | 64283552 |
Victim of chemical submission | 43.96 | 9.88 | 21 | 214735 | 279 | 64283697 |
Lymphocyte count decreased | 43.67 | 9.88 | 258 | 214498 | 40441 | 64243535 |
Renal tubular necrosis | 43.66 | 9.88 | 10 | 214746 | 22100 | 64261876 |
Injury | 43.22 | 9.88 | 327 | 214429 | 55665 | 64228311 |
Cerebral infarction | 42.82 | 9.88 | 44 | 214712 | 41000 | 64242976 |
Skin ulcer | 42.72 | 9.88 | 50 | 214706 | 43924 | 64240052 |
Cerebral haemorrhage | 42.60 | 9.88 | 65 | 214691 | 51025 | 64232951 |
Decreased appetite | 41.99 | 9.88 | 671 | 214085 | 280618 | 64003358 |
Haematochezia | 41.73 | 9.88 | 100 | 214656 | 66273 | 64217703 |
Chronic spontaneous urticaria | 41.57 | 9.88 | 24 | 214732 | 479 | 64283497 |
Maternal exposure timing unspecified | 41.30 | 9.88 | 48 | 214708 | 2659 | 64281317 |
Rheumatoid arthritis | 40.74 | 9.88 | 771 | 213985 | 163523 | 64120453 |
Oedema peripheral | 40.63 | 9.88 | 476 | 214280 | 209841 | 64074135 |
Osteonecrosis of jaw | 40.08 | 9.88 | 44 | 214712 | 39781 | 64244195 |
Skin plaque | 39.35 | 9.88 | 90 | 214666 | 8850 | 64275126 |
Neuroleptic malignant syndrome | 39.24 | 9.88 | 17 | 214739 | 24979 | 64258997 |
Throat tightness | 39.18 | 9.88 | 167 | 214589 | 22993 | 64260983 |
Hypocalcaemia | 38.94 | 9.88 | 49 | 214707 | 41704 | 64242272 |
Shock haemorrhagic | 38.84 | 9.88 | 5 | 214751 | 16786 | 64267190 |
Eye swelling | 38.73 | 9.88 | 162 | 214594 | 22119 | 64261857 |
Mental status changes | 38.57 | 9.88 | 92 | 214664 | 61070 | 64222906 |
Sinus disorder | 38.52 | 9.88 | 134 | 214622 | 16774 | 64267202 |
C-reactive protein increased | 38.23 | 9.88 | 174 | 214582 | 94735 | 64189241 |
Pregnancy | 38.08 | 9.88 | 154 | 214602 | 20711 | 64263265 |
Perfume sensitivity | 38.02 | 9.88 | 25 | 214731 | 634 | 64283342 |
Live birth | 37.91 | 9.88 | 102 | 214654 | 11102 | 64272874 |
Peritonitis | 37.75 | 9.88 | 18 | 214738 | 25005 | 64258971 |
Blood pressure fluctuation | 37.74 | 9.88 | 72 | 214684 | 51799 | 64232177 |
Upper gastrointestinal haemorrhage | 37.60 | 9.88 | 37 | 214719 | 35183 | 64248793 |
Pneumocystis jirovecii pneumonia | 37.13 | 9.88 | 23 | 214733 | 27611 | 64256365 |
Inappropriate antidiuretic hormone secretion | 36.87 | 9.88 | 14 | 214742 | 22275 | 64261701 |
Pulmonary oedema | 36.84 | 9.88 | 136 | 214620 | 78538 | 64205438 |
Rectal haemorrhage | 36.64 | 9.88 | 96 | 214660 | 61721 | 64222255 |
Intentional product misuse | 36.52 | 9.88 | 121 | 214635 | 72174 | 64211802 |
Labelled drug-drug interaction medication error | 36.26 | 9.88 | 14 | 214742 | 22048 | 64261928 |
Lacrimation increased | 35.57 | 9.88 | 138 | 214618 | 18208 | 64265768 |
Agranulocytosis | 35.51 | 9.88 | 45 | 214711 | 38184 | 64245792 |
Ventricular tachycardia | 35.44 | 9.88 | 37 | 214719 | 34228 | 64249748 |
Neoplasm progression | 35.24 | 9.88 | 51 | 214705 | 40913 | 64243063 |
Urinary tract infection | 34.70 | 9.88 | 552 | 214204 | 231044 | 64052932 |
Sudden infant death syndrome | 34.64 | 9.88 | 15 | 214741 | 156 | 64283820 |
Mucosal inflammation | 34.26 | 9.88 | 101 | 214655 | 62483 | 64221493 |
Thrombotic microangiopathy | 33.97 | 9.88 | 7 | 214749 | 16648 | 64267328 |
Flushing | 33.95 | 9.88 | 406 | 214350 | 78242 | 64205734 |
Scratch | 33.90 | 9.88 | 70 | 214686 | 6419 | 64277557 |
Posterior reversible encephalopathy syndrome | 33.86 | 9.88 | 17 | 214739 | 22929 | 64261047 |
Adverse event | 33.56 | 9.88 | 236 | 214520 | 39253 | 64244723 |
Exposure during pregnancy | 33.54 | 9.88 | 401 | 214355 | 77274 | 64206702 |
Hypokalaemia | 33.35 | 9.88 | 253 | 214503 | 121650 | 64162326 |
Neutrophil count decreased | 33.24 | 9.88 | 138 | 214618 | 77058 | 64206918 |
Unresponsive to stimuli | 33.23 | 9.88 | 74 | 214682 | 50319 | 64233657 |
Asthenia | 33.14 | 9.88 | 1130 | 213626 | 426914 | 63857062 |
Neonatal hypoacusis | 32.88 | 9.88 | 9 | 214747 | 17 | 64283959 |
Pericardial effusion | 32.67 | 9.88 | 50 | 214706 | 39204 | 64244772 |
Hyperglycaemia | 32.22 | 9.88 | 100 | 214656 | 60868 | 64223108 |
Orthostatic hypotension | 32.18 | 9.88 | 67 | 214689 | 46671 | 64237305 |
Loss of consciousness | 32.15 | 9.88 | 327 | 214429 | 148038 | 64135938 |
Head deformity | 31.94 | 9.88 | 10 | 214746 | 36 | 64283940 |
Auditory neuropathy spectrum disorder | 31.91 | 9.88 | 9 | 214747 | 20 | 64283956 |
Blood lactate dehydrogenase increased | 31.71 | 9.88 | 38 | 214718 | 33040 | 64250936 |
Exposure via body fluid | 31.71 | 9.88 | 16 | 214740 | 241 | 64283735 |
Paraesthesia oral | 31.60 | 9.88 | 106 | 214650 | 13025 | 64270951 |
Vomiting | 31.49 | 9.88 | 1507 | 213249 | 549610 | 63734366 |
Bacteraemia | 31.44 | 9.88 | 26 | 214730 | 26885 | 64257091 |
Bacterial test positive | 31.29 | 9.88 | 69 | 214687 | 6621 | 64277355 |
Abdominal pain upper | 31.11 | 9.88 | 783 | 213973 | 174247 | 64109729 |
Ileus | 31.02 | 9.88 | 19 | 214737 | 22947 | 64261029 |
Liver function test abnormal | 30.99 | 9.88 | 98 | 214658 | 59303 | 64224673 |
Respiratory depression | 30.83 | 9.88 | 20 | 214736 | 23423 | 64260553 |
Intervertebral discitis | 30.81 | 9.88 | 50 | 214706 | 3807 | 64280169 |
Chronic sinusitis | 30.69 | 9.88 | 66 | 214690 | 6226 | 64277750 |
Disease recurrence | 30.42 | 9.88 | 36 | 214720 | 31474 | 64252502 |
Eye pruritus | 30.30 | 9.88 | 102 | 214654 | 12557 | 64271419 |
Tachypnoea | 29.44 | 9.88 | 27 | 214729 | 26544 | 64257432 |
Left ventricular dysfunction | 29.15 | 9.88 | 10 | 214746 | 16944 | 64267032 |
Nasal congestion | 28.91 | 9.88 | 315 | 214441 | 59343 | 64224633 |
Potassium wasting nephropathy | 28.76 | 9.88 | 13 | 214743 | 151 | 64283825 |
Prostate cancer | 28.71 | 9.88 | 15 | 214741 | 19780 | 64264196 |
Premature delivery | 28.61 | 9.88 | 13 | 214743 | 18576 | 64265400 |
Adjustment disorder with depressed mood | 28.54 | 9.88 | 38 | 214718 | 2419 | 64281557 |
Feeling hot | 28.41 | 9.88 | 254 | 214502 | 45409 | 64238567 |
White blood cell count decreased | 28.28 | 9.88 | 363 | 214393 | 157474 | 64126502 |
Anuria | 28.06 | 9.88 | 14 | 214742 | 18950 | 64265026 |
Oliguria | 27.98 | 9.88 | 7 | 214749 | 14569 | 64269407 |
Cestode infection | 27.71 | 9.88 | 15 | 214741 | 263 | 64283713 |
Seasonal allergy | 27.64 | 9.88 | 94 | 214662 | 11632 | 64272344 |
Penis injury | 27.61 | 9.88 | 12 | 214744 | 126 | 64283850 |
Urticaria thermal | 27.60 | 9.88 | 13 | 214743 | 167 | 64283809 |
Acute respiratory distress syndrome | 27.49 | 9.88 | 55 | 214701 | 38880 | 64245096 |
Transaminases increased | 27.39 | 9.88 | 68 | 214688 | 44526 | 64239450 |
Haematotoxicity | 27.19 | 9.88 | 5 | 214751 | 12891 | 64271085 |
Myelodysplastic syndrome | 27.17 | 9.88 | 31 | 214725 | 27548 | 64256428 |
Alanine aminotransferase increased | 27.09 | 9.88 | 314 | 214442 | 138717 | 64145259 |
Transplant rejection | 27.05 | 9.88 | 12 | 214744 | 17389 | 64266587 |
Plasma cell myeloma | 26.96 | 9.88 | 72 | 214684 | 46003 | 64237973 |
Parathyroid gland enlargement | 26.96 | 9.88 | 12 | 214744 | 134 | 64283842 |
Lichen sclerosus | 26.94 | 9.88 | 23 | 214733 | 874 | 64283102 |
Renal injury | 26.70 | 9.88 | 9 | 214747 | 15420 | 64268556 |
Vocal cord dysfunction | 26.68 | 9.88 | 17 | 214739 | 408 | 64283568 |
Extrapyramidal disorder | 26.65 | 9.88 | 16 | 214740 | 19536 | 64264440 |
Nasal oedema | 26.57 | 9.88 | 24 | 214732 | 984 | 64282992 |
Chronic kidney disease | 26.54 | 9.88 | 101 | 214655 | 57818 | 64226158 |
Nasal turbinate hypertrophy | 26.52 | 9.88 | 19 | 214737 | 556 | 64283420 |
Adverse drug reaction | 26.32 | 9.88 | 249 | 214507 | 45215 | 64238761 |
Haemodialysis | 26.20 | 9.88 | 12 | 214744 | 17065 | 64266911 |
Mast cell activation syndrome | 26.14 | 9.88 | 16 | 214740 | 357 | 64283619 |
Psychotic disorder | 26.03 | 9.88 | 47 | 214709 | 34531 | 64249445 |
Nausea | 25.91 | 9.88 | 2259 | 212497 | 783541 | 63500435 |
Restrictive pulmonary disease | 25.86 | 9.88 | 34 | 214722 | 2138 | 64281838 |
Sneezing | 25.82 | 9.88 | 110 | 214646 | 15141 | 64268835 |
Urticaria chronic | 25.76 | 9.88 | 17 | 214739 | 434 | 64283542 |
Metastases to liver | 25.73 | 9.88 | 25 | 214731 | 23916 | 64260060 |
Palmar-plantar erythrodysaesthesia syndrome | 25.67 | 9.88 | 35 | 214721 | 28784 | 64255192 |
Menstruation delayed | 25.57 | 9.88 | 25 | 214731 | 1134 | 64282842 |
Cardiomyopathy | 25.53 | 9.88 | 28 | 214728 | 25328 | 64258648 |
Coronary artery disease | 25.42 | 9.88 | 109 | 214647 | 60324 | 64223652 |
Proteinuria | 25.37 | 9.88 | 33 | 214723 | 27690 | 64256286 |
Hepatotoxicity | 25.28 | 9.88 | 60 | 214696 | 39902 | 64244074 |
Forced expiratory volume | 25.27 | 9.88 | 10 | 214746 | 81 | 64283895 |
Lip pruritus | 25.20 | 9.88 | 20 | 214736 | 685 | 64283291 |
Blood urine present | 24.91 | 9.88 | 124 | 214632 | 18216 | 64265760 |
Aspartate aminotransferase increased | 24.73 | 9.88 | 267 | 214489 | 119521 | 64164455 |
Thrombosis | 24.73 | 9.88 | 136 | 214620 | 70506 | 64213470 |
Ventricular fibrillation | 24.41 | 9.88 | 26 | 214730 | 23834 | 64260142 |
Cystic fibrosis pancreatic | 24.37 | 9.88 | 9 | 214747 | 59 | 64283917 |
Hyper IgE syndrome | 24.32 | 9.88 | 17 | 214739 | 478 | 64283498 |
Ear infection | 24.23 | 9.88 | 147 | 214609 | 23257 | 64260719 |
Electrolyte imbalance | 24.20 | 9.88 | 29 | 214727 | 25214 | 64258762 |
Haematemesis | 24.19 | 9.88 | 78 | 214678 | 46921 | 64237055 |
Red blood cell sedimentation rate abnormal | 24.18 | 9.88 | 12 | 214744 | 16294 | 64267682 |
Pathogen resistance | 24.13 | 9.88 | 6 | 214750 | 12537 | 64271439 |
Osteomyelitis | 24.07 | 9.88 | 34 | 214722 | 27553 | 64256423 |
Acute hepatic failure | 23.98 | 9.88 | 31 | 214725 | 26081 | 64257895 |
Cardiotoxicity | 23.91 | 9.88 | 3 | 214753 | 10271 | 64273705 |
Prescribed overdose | 23.85 | 9.88 | 132 | 214624 | 20199 | 64263777 |
Allergy test positive | 23.85 | 9.88 | 16 | 214740 | 420 | 64283556 |
Retinitis | 23.84 | 9.88 | 32 | 214724 | 2053 | 64281923 |
Bronchial neoplasm | 23.62 | 9.88 | 16 | 214740 | 427 | 64283549 |
Localised infection | 23.61 | 9.88 | 40 | 214716 | 30121 | 64253855 |
Drug level increased | 23.56 | 9.88 | 49 | 214707 | 34147 | 64249829 |
Specific gravity urine increased | 23.52 | 9.88 | 16 | 214740 | 430 | 64283546 |
Monocyte percentage increased | 23.34 | 9.88 | 31 | 214725 | 1969 | 64282007 |
Pregnancy on contraceptive | 23.18 | 9.88 | 20 | 214736 | 771 | 64283205 |
Dry mouth | 23.13 | 9.88 | 305 | 214451 | 60113 | 64223863 |
Subdural haematoma | 23.09 | 9.88 | 36 | 214720 | 28018 | 64255958 |
Gastric haemorrhage | 23.09 | 9.88 | 8 | 214748 | 13473 | 64270503 |
Product prescribing error | 23.08 | 9.88 | 52 | 214704 | 35217 | 64248759 |
Haematoma | 22.95 | 9.88 | 78 | 214678 | 46172 | 64237804 |
Demyelination | 22.91 | 9.88 | 62 | 214694 | 6772 | 64277204 |
Dialysis | 22.85 | 9.88 | 14 | 214742 | 16906 | 64267070 |
Status epilepticus | 22.85 | 9.88 | 23 | 214733 | 21640 | 64262336 |
Hyperammonaemia | 22.79 | 9.88 | 3 | 214753 | 9901 | 64274075 |
Escherichia infection | 22.74 | 9.88 | 11 | 214745 | 15157 | 64268819 |
Polymenorrhoea | 22.69 | 9.88 | 21 | 214735 | 889 | 64283087 |
Crying | 22.62 | 9.88 | 129 | 214627 | 19961 | 64264015 |
Metastases to central nervous system | 22.58 | 9.88 | 9 | 214747 | 13903 | 64270073 |
Nocturnal fear | 22.40 | 9.88 | 6 | 214750 | 10 | 64283966 |
Creatinine renal clearance decreased | 22.33 | 9.88 | 10 | 214746 | 14411 | 64269565 |
Cytokine release syndrome | 22.32 | 9.88 | 132 | 214624 | 20697 | 64263279 |
C-reactive protein abnormal | 22.30 | 9.88 | 39 | 214717 | 29008 | 64254968 |
Basal cell carcinoma | 22.26 | 9.88 | 43 | 214713 | 30795 | 64253181 |
Fracture | 22.06 | 9.88 | 18 | 214738 | 18737 | 64265239 |
Immune reconstitution inflammatory syndrome | 22.06 | 9.88 | 7 | 214749 | 12463 | 64271513 |
Bronchial disorder | 21.99 | 9.88 | 31 | 214725 | 2084 | 64281892 |
Diffuse large B-cell lymphoma | 21.88 | 9.88 | 4 | 214752 | 10357 | 64273619 |
Bradycardia | 21.88 | 9.88 | 270 | 214486 | 117949 | 64166027 |
Migraine | 21.79 | 9.88 | 311 | 214445 | 62366 | 64221610 |
Penile haemorrhage | 21.67 | 9.88 | 16 | 214740 | 491 | 64283485 |
Infusion site pain | 21.64 | 9.88 | 80 | 214676 | 10317 | 64273659 |
Cholecystitis chronic | 21.50 | 9.88 | 74 | 214682 | 9213 | 64274763 |
Bacterial test | 21.14 | 9.88 | 23 | 214733 | 1184 | 64282792 |
Middle insomnia | 21.12 | 9.88 | 92 | 214664 | 12785 | 64271191 |
Lip dry | 21.09 | 9.88 | 49 | 214707 | 4869 | 64279107 |
Neoplasm malignant | 20.98 | 9.88 | 31 | 214725 | 24657 | 64259319 |
Rhinitis | 20.89 | 9.88 | 81 | 214675 | 10684 | 64273292 |
Graft versus host disease | 20.74 | 9.88 | 10 | 214746 | 13803 | 64270173 |
Hyperbilirubinaemia | 20.71 | 9.88 | 24 | 214732 | 21181 | 64262795 |
Tubulointerstitial nephritis | 20.70 | 9.88 | 45 | 214711 | 30864 | 64253112 |
Sinus congestion | 20.70 | 9.88 | 104 | 214652 | 15335 | 64268641 |
Eosinophilic oesophagitis | 20.64 | 9.88 | 15 | 214741 | 449 | 64283527 |
Anxiety | 20.62 | 9.88 | 848 | 213908 | 201801 | 64082175 |
Cellulitis | 20.46 | 9.88 | 206 | 214550 | 93451 | 64190525 |
Hepatic encephalopathy | 20.41 | 9.88 | 24 | 214732 | 21042 | 64262934 |
Dislocation of vertebra | 20.35 | 9.88 | 37 | 214719 | 3087 | 64280889 |
Gastric ulcer | 20.26 | 9.88 | 44 | 214712 | 30190 | 64253786 |
Tuberculosis | 20.25 | 9.88 | 9 | 214747 | 13029 | 64270947 |
Hip fracture | 20.25 | 9.88 | 37 | 214719 | 27062 | 64256914 |
Hallucination, auditory | 20.25 | 9.88 | 16 | 214740 | 16923 | 64267053 |
Lung neoplasm malignant | 20.18 | 9.88 | 25 | 214731 | 21423 | 64262553 |
Eosinophilic colitis | 20.17 | 9.88 | 14 | 214742 | 389 | 64283587 |
Metastases to lung | 20.10 | 9.88 | 13 | 214743 | 15251 | 64268725 |
Cardiac failure acute | 20.09 | 9.88 | 15 | 214741 | 16329 | 64267647 |
Urine ketone body present | 20.08 | 9.88 | 38 | 214718 | 3269 | 64280707 |
Intentional overdose | 19.99 | 9.88 | 197 | 214559 | 89747 | 64194229 |
Tongue pruritus | 19.97 | 9.88 | 15 | 214741 | 473 | 64283503 |
Myoclonus | 19.95 | 9.88 | 33 | 214723 | 25085 | 64258891 |
Eosinophilic granulomatosis with polyangiitis | 19.89 | 9.88 | 35 | 214721 | 2847 | 64281129 |
Cough | 19.88 | 9.88 | 1212 | 213544 | 300936 | 63983040 |
Leukocytosis | 19.87 | 9.88 | 62 | 214694 | 37678 | 64246298 |
Nitrite urine present | 19.79 | 9.88 | 21 | 214735 | 1051 | 64282925 |
Enthesopathy | 19.76 | 9.88 | 4 | 214752 | 9634 | 64274342 |
Urinary casts | 19.62 | 9.88 | 21 | 214735 | 1061 | 64282915 |
Intestinal ischaemia | 19.53 | 9.88 | 7 | 214749 | 11542 | 64272434 |
Swollen tongue | 19.52 | 9.88 | 190 | 214566 | 34764 | 64249212 |
Therapy partial responder | 19.52 | 9.88 | 5 | 214751 | 10243 | 64273733 |
Colitis | 19.44 | 9.88 | 115 | 214641 | 58559 | 64225417 |
Klebsiella infection | 19.36 | 9.88 | 10 | 214746 | 13271 | 64270705 |
Coagulopathy | 19.35 | 9.88 | 49 | 214707 | 31871 | 64252105 |
Haemorrhage intracranial | 19.33 | 9.88 | 31 | 214725 | 23853 | 64260123 |
Mechanical urticaria | 19.25 | 9.88 | 13 | 214743 | 345 | 64283631 |
Haemodynamic instability | 19.23 | 9.88 | 13 | 214743 | 14899 | 64269077 |
Skin burning sensation | 19.22 | 9.88 | 78 | 214678 | 10505 | 64273471 |
Lichen nitidus | 19.20 | 9.88 | 8 | 214748 | 75 | 64283901 |
Skin necrosis | 19.15 | 9.88 | 12 | 214744 | 14317 | 64269659 |
Thymus disorder | 19.12 | 9.88 | 11 | 214745 | 218 | 64283758 |
Muscle rigidity | 19.07 | 9.88 | 18 | 214738 | 17455 | 64266521 |
Arrhythmia | 19.04 | 9.88 | 101 | 214655 | 52843 | 64231133 |
Metastases to bone | 19.04 | 9.88 | 24 | 214732 | 20411 | 64263565 |
Premenstrual syndrome | 19.02 | 9.88 | 15 | 214741 | 509 | 64283467 |
Blood urea increased | 18.96 | 9.88 | 79 | 214677 | 44074 | 64239902 |
Aspergillus infection | 18.92 | 9.88 | 16 | 214740 | 16363 | 64267613 |
Gamma-glutamyltransferase increased | 18.90 | 9.88 | 90 | 214666 | 48420 | 64235556 |
Syncope | 18.78 | 9.88 | 391 | 214365 | 157244 | 64126732 |
Substance abuse | 18.76 | 9.88 | 4 | 214752 | 9288 | 64274688 |
Depressed mood | 18.71 | 9.88 | 214 | 214542 | 40798 | 64243178 |
Musculoskeletal stiffness | 18.69 | 9.88 | 540 | 214216 | 122666 | 64161310 |
Fixed eruption | 18.64 | 9.88 | 29 | 214727 | 2130 | 64281846 |
Generalised tonic-clonic seizure | 18.59 | 9.88 | 69 | 214687 | 39788 | 64244188 |
Weight decreased | 18.59 | 9.88 | 770 | 213986 | 284969 | 63999007 |
Seronegative arthritis | 18.53 | 9.88 | 33 | 214723 | 2710 | 64281266 |
Heparin-induced thrombocytopenia | 18.51 | 9.88 | 3 | 214753 | 8476 | 64275500 |
Second primary malignancy | 18.42 | 9.88 | 9 | 214747 | 12328 | 64271648 |
Multiple sclerosis | 18.38 | 9.88 | 117 | 214639 | 18824 | 64265152 |
Pharyngeal oedema | 18.33 | 9.88 | 101 | 214655 | 15430 | 64268546 |
Ejection fraction decreased | 18.24 | 9.88 | 43 | 214713 | 28664 | 64255312 |
Ehlers-Danlos syndrome | 18.11 | 9.88 | 9 | 214747 | 131 | 64283845 |
Dyshidrotic eczema | 18.09 | 9.88 | 15 | 214741 | 547 | 64283429 |
Magnesium deficiency | 18.07 | 9.88 | 15 | 214741 | 548 | 64283428 |
Hypoxia | 17.98 | 9.88 | 197 | 214559 | 87952 | 64196024 |
Sedation | 17.92 | 9.88 | 74 | 214682 | 41388 | 64242588 |
Bilirubin urine present | 17.79 | 9.88 | 12 | 214744 | 318 | 64283658 |
Herpes zoster | 17.78 | 9.88 | 173 | 214583 | 79014 | 64204962 |
Gait disturbance | 17.69 | 9.88 | 437 | 214319 | 171718 | 64112258 |
Cytomegalovirus viraemia | 17.58 | 9.88 | 7 | 214749 | 10821 | 64273155 |
Encephalitis | 17.54 | 9.88 | 10 | 214746 | 12561 | 64271415 |
Sudden death | 17.30 | 9.88 | 25 | 214731 | 20071 | 64263905 |
Lactose intolerance | 17.29 | 9.88 | 27 | 214729 | 1989 | 64281987 |
Violence-related symptom | 17.25 | 9.88 | 16 | 214740 | 679 | 64283297 |
Intentional product use issue | 17.04 | 9.88 | 427 | 214329 | 94937 | 64189039 |
Tumour lysis syndrome | 16.92 | 9.88 | 24 | 214732 | 19416 | 64264560 |
Pulmonary embolism | 16.86 | 9.88 | 365 | 214391 | 145991 | 64137985 |
Loss of personal independence in daily activities | 16.82 | 9.88 | 157 | 214599 | 72297 | 64211679 |
Angina pectoris | 16.78 | 9.88 | 85 | 214671 | 44996 | 64238980 |
Diabetes mellitus | 16.77 | 9.88 | 141 | 214615 | 66333 | 64217643 |
Treatment noncompliance | 16.75 | 9.88 | 81 | 214675 | 43401 | 64240575 |
Stress cardiomyopathy | 16.73 | 9.88 | 5 | 214751 | 9252 | 64274724 |
Prevertebral soft tissue swelling of cervical space | 16.69 | 9.88 | 6 | 214750 | 36 | 64283940 |
Oral allergy syndrome | 16.69 | 9.88 | 6 | 214750 | 36 | 64283940 |
Pulmonary artery stenosis congenital | 16.66 | 9.88 | 5 | 214751 | 15 | 64283961 |
Osteonecrosis | 16.60 | 9.88 | 44 | 214712 | 28185 | 64255791 |
Fibromyalgia | 16.55 | 9.88 | 187 | 214569 | 35544 | 64248432 |
Blood potassium increased | 16.44 | 9.88 | 39 | 214717 | 25941 | 64258035 |
Pulmonary function test decreased | 16.30 | 9.88 | 53 | 214703 | 6408 | 64277568 |
Photosensitivity reaction | 16.26 | 9.88 | 110 | 214646 | 18063 | 64265913 |
Pharyngeal swelling | 16.25 | 9.88 | 48 | 214708 | 5511 | 64278465 |
Pulmonary hypertension | 16.25 | 9.88 | 81 | 214675 | 43058 | 64240918 |
Myopathy | 16.23 | 9.88 | 21 | 214735 | 17659 | 64266317 |
Hyperplastic cholecystopathy | 16.19 | 9.88 | 8 | 214748 | 115 | 64283861 |
Upper respiratory fungal infection | 16.16 | 9.88 | 11 | 214745 | 296 | 64283680 |
Pulmonary haemorrhage | 16.16 | 9.88 | 12 | 214744 | 13097 | 64270879 |
Pulmonary pain | 16.08 | 9.88 | 30 | 214726 | 2554 | 64281422 |
Therapeutic product effect incomplete | 16.03 | 9.88 | 245 | 214511 | 103237 | 64180739 |
Circulatory collapse | 15.99 | 9.88 | 58 | 214698 | 33674 | 64250302 |
Femur fracture | 15.98 | 9.88 | 59 | 214697 | 34076 | 64249900 |
Anaphylactoid reaction | 15.90 | 9.88 | 43 | 214713 | 4695 | 64279281 |
Pulse absent | 15.87 | 9.88 | 5 | 214751 | 8941 | 64275035 |
Protrusion tongue | 15.79 | 9.88 | 12 | 214744 | 385 | 64283591 |
Oesophagitis | 15.75 | 9.88 | 30 | 214726 | 21600 | 64262376 |
Diabetic ketoacidosis | 15.73 | 9.88 | 49 | 214707 | 29796 | 64254180 |
Panniculitis | 15.68 | 9.88 | 5 | 214751 | 8874 | 64275102 |
Epistaxis | 15.66 | 9.88 | 231 | 214525 | 97900 | 64186076 |
Swelling of eyelid | 15.62 | 9.88 | 27 | 214729 | 2165 | 64281811 |
Deep vein thrombosis postoperative | 15.61 | 9.88 | 21 | 214735 | 1350 | 64282626 |
Duodenal ulcer | 15.60 | 9.88 | 15 | 214741 | 14420 | 64269556 |
Respiratory distress | 15.57 | 9.88 | 106 | 214650 | 52225 | 64231751 |
Hypervolaemia | 15.52 | 9.88 | 70 | 214686 | 38215 | 64245761 |
Anti-cyclic citrullinated peptide antibody | 15.48 | 9.88 | 21 | 214735 | 1361 | 64282615 |
Injection site urticaria | 15.47 | 9.88 | 76 | 214680 | 11105 | 64272871 |
Hypertensive crisis | 15.42 | 9.88 | 23 | 214733 | 18225 | 64265751 |
Neuropathy peripheral | 15.36 | 9.88 | 287 | 214469 | 117238 | 64166738 |
Endometrial ablation | 15.33 | 9.88 | 16 | 214740 | 785 | 64283191 |
Intestinal perforation | 15.32 | 9.88 | 17 | 214739 | 15296 | 64268680 |
Dermatitis contact | 15.30 | 9.88 | 65 | 214691 | 8935 | 64275041 |
Pruritus genital | 15.25 | 9.88 | 18 | 214738 | 1014 | 64282962 |
Reaction to excipient | 15.24 | 9.88 | 21 | 214735 | 1382 | 64282594 |
Cells in urine | 15.14 | 9.88 | 9 | 214747 | 190 | 64283786 |
Gangrene | 15.14 | 9.88 | 3 | 214753 | 7335 | 64276641 |
Ischaemic stroke | 15.07 | 9.88 | 48 | 214708 | 28987 | 64254989 |
Poor feeding infant | 15.05 | 9.88 | 8 | 214748 | 135 | 64283841 |
Rhinorrhoea | 15.04 | 9.88 | 282 | 214474 | 59687 | 64224289 |
Candida infection | 14.91 | 9.88 | 54 | 214702 | 31365 | 64252611 |
Toxic encephalopathy | 14.90 | 9.88 | 7 | 214749 | 9808 | 64274168 |
Anticipatory anxiety | 14.82 | 9.88 | 10 | 214746 | 265 | 64283711 |
Epstein-Barr virus infection | 14.67 | 9.88 | 12 | 214744 | 12476 | 64271500 |
Faecaloma | 14.67 | 9.88 | 7 | 214749 | 9721 | 64274255 |
Therapy cessation | 14.66 | 9.88 | 57 | 214699 | 32432 | 64251544 |
Myocardial ischaemia | 14.64 | 9.88 | 35 | 214721 | 23216 | 64260760 |
Axillary pain | 14.59 | 9.88 | 23 | 214733 | 1709 | 64282267 |
Marginal zone lymphoma | 14.52 | 9.88 | 6 | 214750 | 55 | 64283921 |
Delirium | 14.37 | 9.88 | 154 | 214602 | 69040 | 64214936 |
Blood alkaline phosphatase increased | 14.37 | 9.88 | 119 | 214637 | 56160 | 64227816 |
Activated partial thromboplastin time prolonged | 14.26 | 9.88 | 13 | 214743 | 12818 | 64271158 |
Sensitivity to weather change | 14.26 | 9.88 | 52 | 214704 | 6662 | 64277314 |
Schizophreniform disorder | 14.25 | 9.88 | 8 | 214748 | 151 | 64283825 |
Metabolic disorder | 14.20 | 9.88 | 4 | 214752 | 7693 | 64276283 |
Dyspnoea | 14.12 | 9.88 | 2656 | 212100 | 716018 | 63567958 |
Haemophagocytic lymphohistiocytosis | 14.11 | 9.88 | 23 | 214733 | 17586 | 64266390 |
Kidney transplant rejection | 14.10 | 9.88 | 7 | 214749 | 9504 | 64274472 |
Biliary dyskinesia | 14.09 | 9.88 | 27 | 214729 | 2345 | 64281631 |
Eye infection bacterial | 14.09 | 9.88 | 9 | 214747 | 217 | 64283759 |
Urinary retention | 13.98 | 9.88 | 101 | 214655 | 49100 | 64234876 |
Specific gravity urine decreased | 13.86 | 9.88 | 15 | 214741 | 768 | 64283208 |
Acute graft versus host disease in skin | 13.74 | 9.88 | 3 | 214753 | 6852 | 64277124 |
Wrong technique in product usage process | 13.74 | 9.88 | 144 | 214612 | 64830 | 64219146 |
Cardiac tamponade | 13.72 | 9.88 | 5 | 214751 | 8159 | 64275817 |
Enteritis | 13.70 | 9.88 | 12 | 214744 | 12065 | 64271911 |
White blood cell count increased | 13.68 | 9.88 | 147 | 214609 | 65867 | 64218109 |
Drug level decreased | 13.58 | 9.88 | 11 | 214745 | 11492 | 64272484 |
Enterocolitis | 13.57 | 9.88 | 12 | 214744 | 12006 | 64271970 |
Paternal exposure timing unspecified | 13.56 | 9.88 | 6 | 214750 | 66 | 64283910 |
Hepatic cancer | 13.50 | 9.88 | 4 | 214752 | 7444 | 64276532 |
Pain in extremity | 13.50 | 9.88 | 849 | 213907 | 302236 | 63981740 |
Arteriosclerosis | 13.43 | 9.88 | 20 | 214736 | 15857 | 64268119 |
Ventricular arrhythmia | 13.41 | 9.88 | 4 | 214752 | 7411 | 64276565 |
Poisoning deliberate | 13.40 | 9.88 | 15 | 214741 | 13443 | 64270533 |
Toxic epidermal necrolysis | 13.31 | 9.88 | 71 | 214685 | 37095 | 64246881 |
Culture urine positive | 13.26 | 9.88 | 37 | 214719 | 4114 | 64279862 |
Laryngitis | 13.20 | 9.88 | 72 | 214684 | 10959 | 64273017 |
Bundle branch block right | 13.18 | 9.88 | 9 | 214747 | 10260 | 64273716 |
Vital capacity decreased | 13.10 | 9.88 | 17 | 214739 | 1055 | 64282921 |
Pancreatitis | 13.06 | 9.88 | 131 | 214625 | 59476 | 64224500 |
Food intolerance | 13.05 | 9.88 | 29 | 214727 | 2797 | 64281179 |
Blood pressure decreased | 13.04 | 9.88 | 205 | 214551 | 85994 | 64197982 |
Hemiparesis | 13.04 | 9.88 | 53 | 214703 | 29774 | 64254202 |
Autoimmune arthritis | 13.02 | 9.88 | 7 | 214749 | 121 | 64283855 |
Febrile bone marrow aplasia | 12.99 | 9.88 | 11 | 214745 | 11244 | 64272732 |
Hyperhidrosis | 12.99 | 9.88 | 524 | 214232 | 124396 | 64159580 |
Immunosuppressant drug level increased | 12.98 | 9.88 | 4 | 214752 | 7255 | 64276721 |
Adenovirus infection | 12.96 | 9.88 | 4 | 214752 | 7251 | 64276725 |
Diarrhoea haemorrhagic | 12.93 | 9.88 | 11 | 214745 | 11216 | 64272760 |
Cardiac failure chronic | 12.89 | 9.88 | 7 | 214749 | 9034 | 64274942 |
Urine amphetamine positive | 12.81 | 9.88 | 6 | 214750 | 76 | 64283900 |
Hypernatraemia | 12.79 | 9.88 | 13 | 214743 | 12176 | 64271800 |
Ileus paralytic | 12.77 | 9.88 | 6 | 214750 | 8409 | 64275567 |
Blood calcium decreased | 12.74 | 9.88 | 43 | 214713 | 25511 | 64258465 |
Accidental exposure to product | 12.72 | 9.88 | 45 | 214711 | 26319 | 64257657 |
Rhinitis allergic | 12.71 | 9.88 | 57 | 214699 | 8021 | 64275955 |
Red blood cell count increased | 12.67 | 9.88 | 33 | 214723 | 3522 | 64280454 |
Dry skin | 12.63 | 9.88 | 240 | 214516 | 50921 | 64233055 |
Intestinal obstruction | 12.62 | 9.88 | 70 | 214686 | 36216 | 64247760 |
Venoocclusive liver disease | 12.56 | 9.88 | 9 | 214747 | 10006 | 64273970 |
Pulmonary fibrosis | 12.49 | 9.88 | 54 | 214702 | 29824 | 64254152 |
Pneumonia fungal | 12.48 | 9.88 | 7 | 214749 | 8870 | 64275106 |
Hallucination, visual | 12.45 | 9.88 | 49 | 214707 | 27785 | 64256191 |
Hypothermia | 12.41 | 9.88 | 30 | 214726 | 19826 | 64264150 |
Akathisia | 12.39 | 9.88 | 12 | 214744 | 11498 | 64272478 |
Granulocytopenia | 12.30 | 9.88 | 10 | 214746 | 10430 | 64273546 |
Bruxism | 12.27 | 9.88 | 33 | 214723 | 3591 | 64280385 |
Prothrombin time prolonged | 12.21 | 9.88 | 21 | 214735 | 15720 | 64268256 |
Enterococcal infection | 12.19 | 9.88 | 17 | 214739 | 13849 | 64270127 |
Blood pressure diastolic abnormal | 12.17 | 9.88 | 13 | 214743 | 11904 | 64272072 |
Urine bilirubin decreased | 12.16 | 9.88 | 7 | 214749 | 139 | 64283837 |
Splenomegaly | 12.15 | 9.88 | 26 | 214730 | 17935 | 64266041 |
Inflammation | 12.13 | 9.88 | 149 | 214607 | 65151 | 64218825 |
Peripheral sensory neuropathy | 12.09 | 9.88 | 12 | 214744 | 11366 | 64272610 |
Walking aid user | 11.97 | 9.88 | 47 | 214709 | 6234 | 64277742 |
Lung infiltration | 11.95 | 9.88 | 33 | 214723 | 20856 | 64263120 |
Cachexia | 11.94 | 9.88 | 8 | 214748 | 9209 | 64274767 |
Autophobia | 11.90 | 9.88 | 4 | 214752 | 19 | 64283957 |
Pulmonary alveolar haemorrhage | 11.89 | 9.88 | 9 | 214747 | 9729 | 64274247 |
Epidermolysis bullosa | 11.86 | 9.88 | 8 | 214748 | 212 | 64283764 |
Ataxia | 11.82 | 9.88 | 36 | 214720 | 22048 | 64261928 |
Eosinophil count increased | 11.79 | 9.88 | 84 | 214672 | 14028 | 64269948 |
Ear swelling | 11.72 | 9.88 | 18 | 214738 | 1307 | 64282669 |
Hyperuricaemia | 11.72 | 9.88 | 10 | 214746 | 10181 | 64273795 |
Post viral fatigue syndrome | 11.68 | 9.88 | 9 | 214747 | 295 | 64283681 |
Burns second degree | 11.64 | 9.88 | 15 | 214741 | 925 | 64283051 |
Schizophrenia | 11.62 | 9.88 | 12 | 214744 | 11156 | 64272820 |
Cardiovascular disorder | 11.59 | 9.88 | 22 | 214734 | 15859 | 64268117 |
Idiopathic angioedema | 11.57 | 9.88 | 4 | 214752 | 21 | 64283955 |
Autoimmune disorder | 11.48 | 9.88 | 44 | 214712 | 5772 | 64278204 |
Musculoskeletal pain | 11.42 | 9.88 | 196 | 214560 | 81098 | 64202878 |
Hypophagia | 11.38 | 9.88 | 81 | 214675 | 39506 | 64244470 |
Tachyarrhythmia | 11.36 | 9.88 | 3 | 214753 | 6023 | 64277953 |
Hepatitis | 11.36 | 9.88 | 97 | 214659 | 45485 | 64238491 |
Cystic fibrosis | 11.35 | 9.88 | 31 | 214725 | 3403 | 64280573 |
Renal disorder | 11.35 | 9.88 | 70 | 214686 | 35295 | 64248681 |
Tarsal tunnel syndrome | 11.34 | 9.88 | 11 | 214745 | 494 | 64283482 |
Red cell distribution width increased | 11.31 | 9.88 | 75 | 214681 | 12234 | 64271742 |
Parkinsonism | 11.31 | 9.88 | 19 | 214737 | 14354 | 64269622 |
Haemoglobin abnormal | 11.30 | 9.88 | 3 | 214753 | 6001 | 64277975 |
Colitis ischaemic | 11.24 | 9.88 | 17 | 214739 | 13397 | 64270579 |
Bronchospasm | 11.21 | 9.88 | 116 | 214640 | 21566 | 64262410 |
Spinal compression fracture | 11.20 | 9.88 | 20 | 214736 | 14755 | 64269221 |
Blood glucose increased | 11.17 | 9.88 | 245 | 214511 | 97828 | 64186148 |
Skin toxicity | 11.17 | 9.88 | 4 | 214752 | 6598 | 64277378 |
Hypoaesthesia | 11.08 | 9.88 | 568 | 214188 | 138540 | 64145436 |
Escherichia sepsis | 11.04 | 9.88 | 5 | 214751 | 7160 | 64276816 |
Acidosis | 11.03 | 9.88 | 27 | 214729 | 17768 | 64266208 |
Urobilinogen urine increased | 11.00 | 9.88 | 12 | 214744 | 620 | 64283356 |
Pregnancy with injectable contraceptive | 10.99 | 9.88 | 6 | 214750 | 107 | 64283869 |
Rhinovirus infection | 10.89 | 9.88 | 45 | 214711 | 6111 | 64277865 |
Hemiplegia | 10.88 | 9.88 | 16 | 214740 | 12752 | 64271224 |
Post-tussive vomiting | 10.86 | 9.88 | 4 | 214752 | 26 | 64283950 |
Hepatic lesion | 10.79 | 9.88 | 3 | 214753 | 5821 | 64278155 |
Poisoning | 10.79 | 9.88 | 37 | 214719 | 21842 | 64262134 |
Uterine pain | 10.77 | 9.88 | 7 | 214749 | 174 | 64283802 |
Coronary artery bypass | 10.77 | 9.88 | 3 | 214753 | 5812 | 64278164 |
Microcytosis | 10.75 | 9.88 | 9 | 214747 | 333 | 64283643 |
Oropharyngeal pain | 10.73 | 9.88 | 379 | 214377 | 88488 | 64195488 |
Venous thrombosis | 10.57 | 9.88 | 4 | 214752 | 6377 | 64277599 |
Atopy | 10.55 | 9.88 | 8 | 214748 | 256 | 64283720 |
Differentiation syndrome | 10.54 | 9.88 | 22 | 214734 | 2032 | 64281944 |
Large intestine perforation | 10.54 | 9.88 | 16 | 214740 | 12588 | 64271388 |
Benign prostatic hyperplasia | 10.53 | 9.88 | 9 | 214747 | 9156 | 64274820 |
Deafness | 10.51 | 9.88 | 29 | 214727 | 18330 | 64265646 |
Pneumonitis | 10.49 | 9.88 | 112 | 214644 | 50253 | 64233723 |
Postmortem blood drug level | 10.49 | 9.88 | 8 | 214748 | 258 | 64283718 |
Bacterial infection | 10.49 | 9.88 | 45 | 214711 | 24905 | 64259071 |
Renal cyst | 10.47 | 9.88 | 16 | 214740 | 12554 | 64271422 |
Lower gastrointestinal haemorrhage | 10.44 | 9.88 | 19 | 214737 | 13920 | 64270056 |
Anal abscess | 10.44 | 9.88 | 6 | 214750 | 7502 | 64276474 |
Generalised anxiety disorder | 10.41 | 9.88 | 21 | 214735 | 1894 | 64282082 |
Neutropenic sepsis | 10.39 | 9.88 | 41 | 214715 | 23231 | 64260745 |
Breast cancer stage III | 10.39 | 9.88 | 27 | 214729 | 2878 | 64281098 |
Pulmonary toxicity | 10.34 | 9.88 | 8 | 214748 | 8553 | 64275423 |
Alanine aminotransferase abnormal | 10.32 | 9.88 | 5 | 214751 | 6883 | 64277093 |
Hypoaesthesia oral | 10.30 | 9.88 | 70 | 214686 | 11510 | 64272466 |
Nystagmus | 10.30 | 9.88 | 9 | 214747 | 9059 | 64274917 |
Emotional distress | 10.29 | 9.88 | 173 | 214583 | 35865 | 64248111 |
Agitation | 10.28 | 9.88 | 220 | 214536 | 88147 | 64195829 |
Sleep disorder | 10.27 | 9.88 | 266 | 214490 | 59443 | 64224533 |
Bicuspid aortic valve | 10.26 | 9.88 | 4 | 214752 | 31 | 64283945 |
Urticaria pressure | 10.25 | 9.88 | 3 | 214753 | 8 | 64283968 |
Urine output decreased | 10.24 | 9.88 | 25 | 214731 | 16467 | 64267509 |
Exposure to allergen | 10.23 | 9.88 | 7 | 214749 | 190 | 64283786 |
Tendon disorder | 10.20 | 9.88 | 45 | 214711 | 6287 | 64277689 |
Laryngeal stenosis | 10.18 | 9.88 | 13 | 214743 | 794 | 64283182 |
Spinal fusion surgery | 10.18 | 9.88 | 31 | 214725 | 3620 | 64280356 |
Periorbital discomfort | 10.15 | 9.88 | 4 | 214752 | 32 | 64283944 |
Prosopagnosia | 10.15 | 9.88 | 4 | 214752 | 32 | 64283944 |
Blood albumin decreased | 10.14 | 9.88 | 36 | 214720 | 21037 | 64262939 |
Transient ischaemic attack | 10.14 | 9.88 | 96 | 214660 | 44086 | 64239890 |
Iron deficiency anaemia | 10.14 | 9.88 | 38 | 214718 | 21851 | 64262125 |
Papule | 10.14 | 9.88 | 45 | 214711 | 6305 | 64277671 |
Portal hypertension | 10.13 | 9.88 | 4 | 214752 | 6215 | 64277761 |
Cardiac disorder | 10.12 | 9.88 | 128 | 214628 | 55688 | 64228288 |
Pneumothorax | 10.11 | 9.88 | 44 | 214712 | 24254 | 64259722 |
Nail dystrophy | 10.11 | 9.88 | 13 | 214743 | 800 | 64283176 |
Cholestasis | 10.09 | 9.88 | 98 | 214658 | 44774 | 64239202 |
Pulmonary congestion | 10.08 | 9.88 | 43 | 214713 | 23837 | 64260139 |
Acute pulmonary oedema | 10.01 | 9.88 | 17 | 214739 | 12792 | 64271184 |
Bronchial haemorrhage | 9.98 | 9.88 | 16 | 214740 | 1206 | 64282770 |
Acute coronary syndrome | 9.97 | 9.88 | 32 | 214724 | 19278 | 64264698 |
Angina unstable | 9.96 | 9.88 | 23 | 214733 | 15444 | 64268532 |
Apnoea | 9.96 | 9.88 | 12 | 214744 | 10410 | 64273566 |
Sunburn | 9.96 | 9.88 | 29 | 214727 | 3303 | 64280673 |
Strabismus | 9.95 | 9.88 | 22 | 214734 | 2115 | 64281861 |
Hydronephrosis | 9.93 | 9.88 | 20 | 214736 | 14105 | 64269871 |
Pancreatitis acute | 9.89 | 9.88 | 93 | 214663 | 42762 | 64241214 |
None
Source | Code | Description |
---|---|---|
ATC | R06AE07 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Piperazine derivatives |
ATC | S01GX12 | SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Other antiallergics |
FDA MoA | N0000000190 | Histamine H1 Receptor Antagonists |
FDA EPC | N0000175587 | Histamine-1 Receptor Antagonist |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
CHEBI has role | CHEBI:78298 | environmental contaminants |
MeSH PA | D018926 | Anti-Allergic Agents |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D039563 | Histamine H1 Antagonists, Non-Sedating |
MeSH PA | D018377 | Neurotransmitter Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Sneezing | indication | 76067001 | |
Common cold | indication | 82272006 | DOID:10459 |
Chronic idiopathic urticaria | indication | 302162004 | |
Seasonal allergic rhinitis | indication | 367498001 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Atopic dermatitis | off-label use | 24079001 | DOID:3310 |
Urticaria | off-label use | 126485001 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic renal failure syndrome | contraindication | 90688005 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Drowsy | contraindication | 271782001 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Hypertensive urgency | contraindication | 443482000 | |
Hemodialysis with High-Flux Membrane | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.03 | acidic |
pKa2 | 8.21 | Basic |
pKa3 | 3.72 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
5MG;120MG | ZYRTEC-D 12 HOUR | J AND J CONSUMER INC | N021150 | Nov. 9, 2007 | OTC | TABLET, EXTENDED RELEASE | ORAL | 7226614 | June 10, 2022 | TREATMENT OF SEASONAL AND PERENNIAL ALLERGIC RHINITIS SYMPTOMS |
10MG/ML (10MG/ML) | QUZYTTIR | JDP | N211415 | Oct. 4, 2019 | RX | SOLUTION | INTRAVENOUS | 8513259 | Feb. 11, 2030 | METHOD OF INCREASING PEAK PLASMA OR ONSET OF PLASMA CONCENTRATION BY INTRAVENOUS INJECTION IN INDIVIDUALS IN NEED OF TREATMENT FOR ACUTE URTICARIA |
10MG/ML (10MG/ML) | QUZYTTIR | JDP | N211415 | Oct. 4, 2019 | RX | SOLUTION | INTRAVENOUS | 9119771 | Feb. 11, 2030 | TREATMENT OF ACUTE URTICARIA |
10MG/ML (10MG/ML) | QUZYTTIR | JDP | N211415 | Oct. 4, 2019 | RX | SOLUTION | INTRAVENOUS | 9180090 | Feb. 11, 2030 | TREATMENT OF ACUTE URTICARIA |
10MG/ML (10MG/ML) | QUZYTTIR | JDP | N211415 | Oct. 4, 2019 | RX | SOLUTION | INTRAVENOUS | 8263581 | Feb. 28, 2030 | TREATMENT OF ACUTE URTICARIA |
10MG/ML (10MG/ML) | QUZYTTIR | JDP | N211415 | Oct. 4, 2019 | RX | SOLUTION | INTRAVENOUS | 8314083 | Feb. 28, 2030 | METHOD OF TREATMENT IN PATIENTS WITH CONCOMITANT ANGIOEDEMA |
EQ 0.24% BASE | ZERVIATE | EYEVANCE | N208694 | May 30, 2017 | RX | SOLUTION/DROPS | OPHTHALMIC | 8829005 | March 15, 2030 | TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS |
EQ 0.24% BASE | ZERVIATE | EYEVANCE | N208694 | May 30, 2017 | RX | SOLUTION/DROPS | OPHTHALMIC | 9993471 | March 15, 2030 | TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10MG/ML (10MG/ML) | QUZYTTIR | JDP | N211415 | Oct. 4, 2019 | RX | SOLUTION | INTRAVENOUS | Oct. 4, 2022 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 7.91 | WOMBAT-PK | CHEMBL | |||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 4.52 | CHEMBL | |||||
Angiopoietin-1 receptor | Kinase | Kd | 4.05 | CHEMBL |
ID | Source |
---|---|
4024005 | VUID |
N0000022010 | NUI |
D00664 | KEGG_DRUG |
83881-52-1 | SECONDARY_CAS_RN |
203150 | RXNORM |
4020943 | VANDF |
4024005 | VANDF |
C0055147 | UMLSCUI |
CHEBI:3561 | CHEBI |
CHEMBL1000 | ChEMBL_ID |
CHEMBL1607273 | ChEMBL_ID |
CHEMBL1201113 | ChEMBL_ID |
DB00341 | DRUGBANK_ID |
D017332 | MESH_DESCRIPTOR_UI |
2678 | PUBCHEM_CID |
1222 | IUPHAR_LIGAND_ID |
5520 | INN_ID |
YO7261ME24 | UNII |
130140 | MMSL |
38293 | MMSL |
4399 | MMSL |
4400 | MMSL |
d03827 | MMSL |
003803 | NDDF |
003804 | NDDF |
108655000 | SNOMEDCT_US |
108656004 | SNOMEDCT_US |
372523007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
good sense all day allergy d | HUMAN OTC DRUG LABEL | 2 | 0113-0147 | TABLET, FILM COATED, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 16 sections |
Good Sense All Day Allergy D | HUMAN OTC DRUG LABEL | 2 | 0113-0176 | TABLET, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 16 sections |
Good Sense Childrens All Day Allergy | HUMAN OTC DRUG LABEL | 1 | 0113-0189 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Good Sense Childrens All Day Allergy | HUMAN OTC DRUG LABEL | 1 | 0113-0503 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
good sense all day allergy | HUMAN OTC DRUG LABEL | 1 | 0113-1036 | CAPSULE, LIQUID FILLED | 10 mg | ORAL | ANDA | 16 sections |
All Day Allergy-D | HUMAN OTC DRUG LABEL | 2 | 0113-2176 | TABLET, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 16 sections |
Basic Care All Day Allergy | HUMAN OTC DRUG LABEL | 1 | 0113-7002 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 16 sections |
BASIC CARE ALL DAY ALLERGY | HUMAN OTC DRUG LABEL | 1 | 0113-7036 | CAPSULE, LIQUID FILLED | 10 mg | ORAL | ANDA | 16 sections |
basic care childrens all day allergy | HUMAN OTC DRUG LABEL | 1 | 0113-7189 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
basic care childrens all day allergy | HUMAN OTC DRUG LABEL | 1 | 0113-7475 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Good Sense all day allergy | HUMAN OTC DRUG LABEL | 1 | 0113-9458 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 16 sections |
Cetirizine Hydrochloride | HUMAN OTC DRUG LABEL | 1 | 0121-4780 | SYRUP | 5 mg | ORAL | ANDA | 17 sections |
Cetirizine Hydrochloride (Allergy) | Human OTC Drug Label | 1 | 0363-0068 | CAPSULE | 10 mg | ORAL | ANDA | 16 sections |
Cetirizine Hydrochloride | Human OTC Drug Label | 1 | 0363-0471 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 14 sections |
Wal Zyr | HUMAN OTC DRUG LABEL | 1 | 0363-0495 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 16 sections |
Wal-Zyr | HUMAN OTC DRUG LABEL | 1 | 0363-0606 | TABLET | 10 mg | ORAL | ANDA | 17 sections |
Wal-Zyr | HUMAN OTC DRUG LABEL | 1 | 0363-0606 | TABLET | 10 mg | ORAL | ANDA | 17 sections |
Wal-Zyr | HUMAN OTC DRUG LABEL | 1 | 0363-0741 | CAPSULE | 10 mg | ORAL | ANDA | 16 sections |
Wal-Zyr | HUMAN OTC DRUG LABEL | 1 | 0363-0921 | CAPSULE | 10 mg | ORAL | NDA | 17 sections |
Childrens Dye Free Wal Zyr | HUMAN OTC DRUG LABEL | 1 | 0363-0953 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Wal-Zyr D | HUMAN OTC DRUG LABEL | 2 | 0363-0989 | TABLET, FILM COATED, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 17 sections |
Cetirizine | HUMAN OTC DRUG LABEL | 1 | 0363-1040 | CAPSULE, LIQUID FILLED | 10 mg | ORAL | ANDA | 16 sections |
WAL ZYR D | HUMAN OTC DRUG LABEL | 2 | 0363-1147 | TABLET, FILM COATED, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 16 sections |
24 HOUR ALLERGY | HUMAN OTC DRUG LABEL | 1 | 0363-1219 | CAPSULE | 10 mg | ORAL | NDA | 17 sections |
childrens dye free wal zyr | HUMAN OTC DRUG LABEL | 1 | 0363-1475 | SOLUTION | 5 mg | ORAL | ANDA | 16 sections |
Wal-Zyr Cetirizine Hydrochloride | HUMAN OTC DRUG LABEL | 1 | 0363-2088 | SOLUTION | 5 mg | ORAL | ANDA | 17 sections |
Wal-Zyr Cetirizine Hydrochloride | HUMAN OTC DRUG LABEL | 1 | 0363-2102 | SOLUTION | 5 mg | ORAL | ANDA | 17 sections |
Wal-Zyr All Day Allergy | HUMAN OTC DRUG LABEL | 1 | 0363-2106 | SOLUTION | 5 mg | ORAL | ANDA | 17 sections |
Childrens Cetirizine Hydrochloride | Human OTC Drug Label | 1 | 0363-4025 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 14 sections |
Childrens Cetirizine Hydrochloride | Human OTC Drug Label | 1 | 0363-4025 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 14 sections |