cetirizine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diphenylmethyl piperazine derivatives	581	83881-51-0

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: cetirizine cetirizine hydrochloride cetirizine dihydrochloride cetirizine HCl

A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. Molecular weight: 388.89 Formula: C21H25ClN2O3 CLOGP: 2.08 LIPINSKI: 0 HAC: 5 HDO: 1 TPSA: 53.01 ALOGS: -3.77 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
10	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.37 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	90 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Dec. 8, 1995	FDA	J AND J CONSUMER INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	1610.74	9.59	1255	147184	44019	46493604
Systemic lupus erythematosus	1294.70	9.59	1298	147141	63882	46473741
Glossodynia	1131.55	9.59	1015	147424	43358	46494265
Alopecia	709.40	9.59	1582	146857	160832	46376791
Abdominal discomfort	683.33	9.59	1493	146946	149672	46387951
Hand deformity	681.15	9.59	686	147753	33888	46503735
Urticaria	653.62	9.59	1267	147172	116625	46420998
Wound	484.67	9.59	638	147801	42164	46495459
Swelling	461.37	9.59	1138	147301	123373	46414250
Pericarditis	372.34	9.59	419	148020	23508	46514115
Hypersensitivity	360.63	9.59	1174	147265	149147	46388476
Pain	343.26	9.59	2638	145801	474310	46063313
Anti-cyclic citrullinated peptide antibody positive	330.39	9.59	354	148085	18791	46518832
Contraindicated product administered	320.86	9.59	754	147685	79193	46458430
Maternal exposure during pregnancy	319.81	9.59	879	147560	101670	46435953
Pruritus	312.98	9.59	1560	146879	240792	46296831
Death	297.23	9.59	379	148060	335169	46202454
Discomfort	292.32	9.59	529	147910	46141	46491482
Asthma	228.36	9.59	725	147714	90817	46446806
Sinusitis	220.84	9.59	907	147532	128861	46408762
Acute kidney injury	212.14	9.59	263	148176	235592	46302031
Rash	207.60	9.59	1882	146557	354630	46182993
Food allergy	205.55	9.59	173	148266	6760	46530863
Fatigue	204.01	9.59	2882	145557	605815	45931808
Hip arthroplasty	194.19	9.59	263	148176	17849	46519774
Completed suicide	186.18	9.59	117	148322	145803	46391820
Toxicity to various agents	184.31	9.59	242	148197	211524	46326099
Angioedema	183.38	9.59	394	148045	38948	46498675
Anaemia	180.14	9.59	337	148102	255442	46282181
Infusion related reaction	178.15	9.59	715	147724	100493	46437130
Rheumatoid factor positive	175.20	9.59	267	148172	20194	46517429
Arthropathy	171.77	9.59	626	147813	84074	46453549
Duodenal ulcer perforation	162.38	9.59	166	148273	8336	46529287
Rheumatoid arthritis	158.84	9.59	1305	147134	238910	46298713
Knee arthroplasty	147.80	9.59	268	148171	23397	46514226
Temperature regulation disorder	145.67	9.59	105	148334	3255	46534368
Product use issue	141.25	9.59	636	147803	94008	46443615
Hepatic enzyme increased	128.38	9.59	558	147881	81229	46456394
Drug interaction	126.44	9.59	287	148152	202807	46334816
Helicobacter infection	117.65	9.59	165	148274	11571	46526052
Anaphylactic reaction	113.12	9.59	399	148040	52713	46484910
Coeliac disease	112.38	9.59	126	148313	7035	46530588
Neutropenia	108.53	9.59	180	148259	143024	46394599
Chronic spontaneous urticaria	103.62	9.59	45	148394	496	46537127
Wheezing	92.13	9.59	375	148064	53011	46484612
Synovitis	91.50	9.59	411	148028	60664	46476959
Thrombocytopenia	91.43	9.59	164	148275	126417	46411206
Headache	91.24	9.59	2074	146365	476278	46061345
Blister	88.00	9.59	327	148112	44304	46493319
Fall	84.12	9.59	657	147782	328440	46209183
Crystal urine present	82.79	9.59	51	148388	1208	46536415
Muscle injury	82.21	9.59	89	148350	4777	46532846
Hyponatraemia	81.85	9.59	122	148317	101210	46436413
Malignant neoplasm progression	81.45	9.59	53	148386	64873	46472750
Hypotension	80.56	9.59	423	148016	232166	46305457
Septic shock	80.08	9.59	42	148397	57851	46479772
Pneumonia	79.12	9.59	790	147649	375530	46162093
Myocardial infarction	78.21	9.59	118	148321	97410	46440213
Sepsis	76.87	9.59	202	148237	135812	46401811
Cardio-respiratory arrest	72.25	9.59	51	148388	59818	46477805
Electric shock	70.72	9.59	41	148398	866	46536757
Urinary sediment present	70.18	9.59	53	148386	1767	46535856
Febrile neutropenia	69.76	9.59	121	148318	94506	46443117
Folliculitis	66.36	9.59	90	148349	6113	46531510
Cardiac failure	65.78	9.59	95	148344	79853	46457770
Throat irritation	65.77	9.59	222	148217	28679	46508944
Ear pain	65.41	9.59	186	148253	21906	46515717
Rash erythematous	63.03	9.59	246	148193	34104	46503519
Erythema	62.11	9.59	711	147728	142109	46395514
Muscle spasticity	62.04	9.59	122	148317	11318	46526305
Disease progression	60.91	9.59	124	148315	91176	46446447
Cardiac failure congestive	59.20	9.59	127	148312	91623	46446000
Immunodeficiency	57.34	9.59	128	148311	12978	46524645
Gastrointestinal haemorrhage	56.97	9.59	99	148340	77274	46460349
Urine abnormality	56.59	9.59	79	148360	5515	46532108
Lymphocyte percentage decreased	55.76	9.59	55	148384	2644	46534979
Pancytopenia	55.49	9.59	117	148322	84941	46452682
Haemoglobin urine present	54.32	9.59	31	148408	635	46536988
Depressed level of consciousness	52.96	9.59	44	148395	47525	46490098
Metabolic acidosis	52.36	9.59	29	148410	38751	46498872
Swollen joint count increased	51.63	9.59	50	148389	2350	46535273
Hereditary angioedema	51.53	9.59	75	148364	5441	46532182
Infective pulmonary exacerbation of cystic fibrosis	51.21	9.59	109	148330	10698	46526925
White blood cells urine positive	50.88	9.59	64	148375	4036	46533587
Blood creatinine increased	50.76	9.59	104	148335	76299	46461324
Multiple organ dysfunction syndrome	50.33	9.59	54	148385	51656	46485967
International normalised ratio increased	50.20	9.59	45	148394	46838	46490785
Body temperature increased	48.87	9.59	182	148257	24679	46512944
Rhabdomyolysis	47.60	9.59	38	148401	41871	46495752
Lower respiratory tract infection	47.47	9.59	319	148120	54770	46482853
Eye pruritus	47.41	9.59	112	148327	11786	46525837
Red blood cells urine positive	46.36	9.59	49	148390	2558	46535065
Rheumatic fever	46.29	9.59	51	148388	2792	46534831
Renal impairment	46.28	9.59	105	148334	74267	46463356
Swelling face	46.17	9.59	308	148131	52751	46484872
Temperature intolerance	46.03	9.59	85	148354	7522	46530101
Respiratory disorder	44.90	9.59	189	148250	27111	46510512
Haemoglobin decreased	44.87	9.59	234	148205	128715	46408908
Interstitial lung disease	44.47	9.59	64	148375	53885	46483738
Neutrophil percentage increased	43.40	9.59	48	148391	2639	46534984
Atrial fibrillation	43.15	9.59	176	148263	103414	46434209
Leukopenia	42.92	9.59	96	148343	68247	46469376
Sleep disorder due to general medical condition, insomnia type	42.82	9.59	67	148372	5182	46532441
Drug intolerance	42.80	9.59	681	147758	146368	46391255
Renal failure	42.46	9.59	201	148238	113393	46424230
Urticaria chronic	41.98	9.59	23	148416	434	46537189
Irritable bowel syndrome	40.38	9.59	130	148309	16385	46521238
Blood immunoglobulin E increased	40.15	9.59	38	148401	1735	46535888
Mechanical urticaria	39.86	9.59	21	148418	365	46537258
Vomiting	39.57	9.59	1117	147322	451677	46085946
Respiratory failure	39.55	9.59	161	148278	94655	46442968
Chest discomfort	39.48	9.59	450	147989	89819	46447804
Post-traumatic stress disorder	39.22	9.59	56	148383	3992	46533631
Bone marrow failure	38.89	9.59	23	148416	29646	46507977
Bursitis	38.78	9.59	145	148294	19697	46517926
Sinus disorder	38.36	9.59	128	148311	16435	46521188
Seasonal allergy	38.25	9.59	111	148328	13223	46524400
Lymphocyte count decreased	38.15	9.59	172	148267	25417	46512206
Joint swelling	37.93	9.59	740	147699	165333	46372290
Lip swelling	37.34	9.59	170	148269	25225	46512398
Pleural effusion	37.07	9.59	137	148302	82815	46454808
Hypokalaemia	37.00	9.59	149	148290	87875	46449748
Insomnia	36.70	9.59	732	147707	164192	46373431
Overdose	36.63	9.59	183	148256	101796	46435827
Haemorrhage	36.18	9.59	75	148364	54794	46482829
Diarrhoea	36.09	9.59	1435	147004	558167	45979456
Drug resistance	35.91	9.59	6	148433	17362	46520261
Plasma cell myeloma	35.46	9.59	54	148385	44424	46493199
Night sweats	35.40	9.59	176	148263	27074	46510549
Respiratory arrest	34.39	9.59	34	148405	33782	46503841
Pneumonia aspiration	34.24	9.59	30	148409	31575	46506048
Cytomegalovirus infection	33.89	9.59	8	148431	18136	46519487
Oral pruritus	33.85	9.59	32	148407	1459	46536164
Urine leukocyte esterase positive	33.76	9.59	41	148398	2494	46535129
Intervertebral discitis	33.70	9.59	41	148398	2498	46535125
Coma	33.44	9.59	86	148353	58263	46479360
Scratch	32.84	9.59	57	148382	4805	46532818
Urine analysis abnormal	32.14	9.59	52	148387	4138	46533485
Cardiac arrest	32.02	9.59	163	148276	90236	46447387
Lip pruritus	31.66	9.59	20	148419	496	46537127
Shock	31.48	9.59	15	148424	21830	46515793
Allergy test positive	31.21	9.59	17	148422	317	46537306
Forced expiratory volume decreased	30.84	9.59	57	148382	5047	46532576
Eye swelling	30.62	9.59	136	148303	19967	46517656
Peritonitis	30.19	9.59	14	148425	20700	46516923
Eosinophilic colitis	30.06	9.59	12	148427	105	46537518
Hypercalcaemia	29.49	9.59	15	148424	21031	46516592
Hepatic function abnormal	29.20	9.59	40	148399	34381	46503242
Hepatic failure	29.19	9.59	38	148401	33378	46504245
Lactic acidosis	29.17	9.59	39	148400	33870	46503753
Flushing	29.10	9.59	324	148115	64290	46473333
Anaphylactoid reaction	29.09	9.59	45	148394	3446	46534177
Eczema	28.84	9.59	135	148304	20265	46517358
Cholecystitis chronic	28.78	9.59	86	148353	10413	46527210
Cerebrovascular accident	28.46	9.59	196	148243	100843	46436780
Hypocalcaemia	28.33	9.59	26	148413	26759	46510864
Sneezing	28.22	9.59	97	148342	12644	46524979
Altered state of consciousness	28.02	9.59	20	148419	23328	46514295
Victim of chemical submission	27.91	9.59	15	148424	272	46537351
Cestode infection	27.91	9.59	15	148424	272	46537351
Skin plaque	27.82	9.59	59	148380	5776	46531847
Neurotoxicity	27.79	9.59	5	148434	13712	46523911
Red blood cell sedimentation rate abnormal	27.60	9.59	5	148434	13644	46523979
Acute myeloid leukaemia	27.49	9.59	8	148431	15770	46521853
Upper respiratory tract infection	27.40	9.59	316	148123	63240	46474383
C-reactive protein abnormal	27.16	9.59	17	148422	21253	46516370
Dehydration	27.09	9.59	351	148088	159189	46378434
Perfume sensitivity	27.04	9.59	19	148420	565	46537058
Mastocytosis	26.86	9.59	17	148422	423	46537200
Drug abuse	26.85	9.59	107	148332	63301	46474322
Chronic kidney disease	26.83	9.59	56	148383	40815	46496808
Decreased appetite	26.81	9.59	444	147995	193392	46344231
Platelet count decreased	26.73	9.59	197	148242	99827	46437796
Lung neoplasm malignant	26.71	9.59	8	148431	15481	46522142
Hyperkalaemia	26.62	9.59	78	148361	50631	46486992
Allergic reaction to excipient	26.42	9.59	15	148424	304	46537319
Drug level increased	26.06	9.59	13	148426	18428	46519195
Disseminated intravascular coagulation	25.96	9.59	14	148425	18991	46518632
Liver function test abnormal	25.51	9.59	70	148369	46417	46491206
Pharyngeal oedema	25.22	9.59	102	148337	14369	46523254
Premature delivery	25.07	9.59	20	148419	22049	46515574
Exposure via body fluid	25.06	9.59	17	148422	477	46537146
Urinary casts	25.03	9.59	17	148422	478	46537145
Lichen sclerosus	24.97	9.59	22	148417	915	46536708
Eosinophilic granulomatosis with polyangiitis	24.95	9.59	30	148409	1806	46535817
Cystic fibrosis pancreatic	24.78	9.59	9	148430	59	46537564
Unresponsive to stimuli	24.75	9.59	40	148399	32134	46505489
Mucosal inflammation	24.26	9.59	55	148384	38921	46498702
Hypoglycaemia	24.12	9.59	90	148349	54259	46483364
Renal tubular necrosis	23.91	9.59	3	148436	10756	46526867
Hyperhidrosis	23.89	9.59	408	148031	88900	46448723
Throat tightness	23.83	9.59	129	148310	20510	46517113
Transaminases increased	23.81	9.59	32	148407	27729	46509894
Urinary tract infection	23.30	9.59	528	147911	219738	46317885
Ascites	23.28	9.59	51	148388	36533	46501090
Nocturnal fear	23.06	9.59	6	148433	9	46537614
Proteinuria	22.90	9.59	12	148427	16541	46521082
Rhinorrhoea	22.84	9.59	242	148197	47423	46490200
Melaena	22.83	9.59	33	148406	27739	46509884
Osteonecrosis	22.77	9.59	29	148410	25715	46511908
Osteonecrosis of jaw	22.69	9.59	47	148392	34355	46503268
Oedema peripheral	22.68	9.59	364	148075	159342	46378281
Intentional overdose	22.49	9.59	118	148321	64826	46472797
Lacrimation increased	22.44	9.59	105	148334	15756	46521867
Mast cell activation syndrome	22.40	9.59	12	148427	216	46537407
Rhinitis allergic	22.27	9.59	60	148379	6848	46530775
Eosinophil count increased	22.10	9.59	65	148374	7801	46529822
Gait disturbance	21.67	9.59	328	148111	144935	46392688
Urine amphetamine positive	21.65	9.59	6	148433	13	46537610
Magnesium deficiency	21.62	9.59	15	148424	437	46537186
Herpes zoster	21.50	9.59	127	148312	67745	46469878
Loss of personal independence in daily activities	21.46	9.59	101	148338	57082	46480541
Feeling hot	21.29	9.59	199	148240	37729	46499894
Menstruation delayed	21.25	9.59	26	148413	1594	46536029
Schizophreniform disorder	21.22	9.59	8	148431	59	46537564
Foetal exposure during pregnancy	21.14	9.59	41	148398	30706	46506917
C-reactive protein increased	21.11	9.59	105	148334	58485	46479138
Cough	21.05	9.59	914	147525	229335	46308288
Hyperpathia	20.52	9.59	6	148433	17	46537606
Therapeutic product effect incomplete	20.36	9.59	155	148284	77998	46459625
Eye infection bacterial	20.05	9.59	9	148430	108	46537515
Obstructive airways disorder	19.88	9.59	90	148349	13322	46524301
Lichen nitidus	19.84	9.59	8	148431	72	46537551
Inappropriate antidiuretic hormone secretion	19.84	9.59	10	148429	14092	46523531
Photosensitivity reaction	19.83	9.59	87	148352	12705	46524918
Paraesthesia oral	19.74	9.59	82	148357	11691	46525932
Therapy non-responder	19.69	9.59	66	148373	41086	46496537
Blood urine present	19.40	9.59	84	148355	12198	46525425
Cerebral haemorrhage	19.36	9.59	38	148401	28333	46509290
Pulmonary oedema	19.34	9.59	90	148349	51015	46486608
Tongue pruritus	19.17	9.59	14	148425	443	46537180
Polymenorrhoea	19.13	9.59	21	148418	1145	46536478
Extrapyramidal disorder	19.11	9.59	6	148433	11262	46526361
Acute myocardial infarction	19.11	9.59	46	148393	31878	46505745
Rheumatoid nodule	18.91	9.59	3	148436	9017	46528606
Ill-defined disorder	18.87	9.59	148	148291	26679	46510944
Generalised tonic-clonic seizure	18.80	9.59	36	148403	27086	46510537
Hypomagnesaemia	18.65	9.59	26	148413	22184	46515439
Subdural haematoma	18.61	9.59	9	148430	12988	46524635
Metastases to liver	18.45	9.59	21	148418	19564	46518059
General physical health deterioration	18.45	9.59	258	148181	115511	46422112
Nasal oedema	18.44	9.59	18	148421	854	46536769
Ehlers-Danlos syndrome	18.43	9.59	8	148431	88	46537535
Productive cough	18.34	9.59	244	148195	50471	46487152
Type 2 diabetes mellitus	18.27	9.59	117	148322	19758	46517865
Blood creatine phosphokinase increased	18.18	9.59	38	148401	27686	46509937
Drug hypersensitivity	18.16	9.59	614	147825	243211	46294412
Palmar-plantar erythrodysaesthesia syndrome	18.13	9.59	23	148416	20428	46517195
Food intolerance	17.97	9.59	29	148410	2303	46535320
Thymus disorder	17.91	9.59	10	148429	196	46537427
Nausea	17.90	9.59	1914	146525	685540	45852083
Shock haemorrhagic	17.78	9.59	3	148436	8621	46529002
Cardiomyopathy	17.72	9.59	15	148424	16058	46521565
Agranulocytosis	17.62	9.59	27	148412	22158	46515465
Chronic sinusitis	17.53	9.59	45	148394	4988	46532635
Premature baby	17.52	9.59	19	148420	18093	46519530
Rhinitis	17.34	9.59	60	148379	7846	46529777
Middle insomnia	17.33	9.59	68	148371	9447	46528176
Tubulointerstitial nephritis	17.31	9.59	13	148426	14775	46522848
Hypoaesthesia oral	17.28	9.59	73	148366	10486	46527137
Metastases to central nervous system	17.28	9.59	7	148432	11214	46526409
Lactose intolerance	17.27	9.59	29	148410	2380	46535243
Body temperature fluctuation	17.27	9.59	25	148414	1805	46535818
Blood lactate dehydrogenase increased	17.21	9.59	24	148415	20476	46517147
Neoplasm progression	17.14	9.59	37	148402	26646	46510977
Skin ulcer	16.98	9.59	50	148389	32408	46505215
Confusional state	16.97	9.59	383	148056	159509	46378114
Seizure	16.95	9.59	282	148157	122772	46414851
Spinal compression fracture	16.91	9.59	10	148429	12893	46524730
Thrombotic microangiopathy	16.89	9.59	3	148436	8303	46529320
Epidermolysis bullosa	16.73	9.59	8	148431	112	46537511
Infusion site pain	16.64	9.59	70	148369	10037	46527586
Femur fracture	16.59	9.59	61	148378	36936	46500687
Sinus congestion	16.55	9.59	84	148355	13025	46524598
Anxiety	16.55	9.59	722	147717	181235	46356388
Transplant rejection	16.47	9.59	5	148434	9591	46528032
Red blood cell count increased	16.46	9.59	28	148411	2322	46535301
Nasal congestion	16.38	9.59	229	148210	47884	46489739
Premenstrual syndrome	16.35	9.59	15	148424	658	46536965
Metastases to bone	16.18	9.59	19	148420	17457	46520166
Osteomyelitis	16.14	9.59	29	148410	22354	46515269
Abdominal pain upper	16.10	9.59	589	147850	144716	46392907
Demyelination	16.02	9.59	47	148392	5633	46531990
Pericardial effusion	15.93	9.59	36	148403	25507	46512116
Bacteraemia	15.92	9.59	13	148426	14166	46523457
Atopy	15.87	9.59	9	148430	182	46537441
Burns second degree	15.65	9.59	15	148424	696	46536927
Delirium	15.65	9.59	63	148376	37165	46500458
Neoplasm malignant	15.59	9.59	32	148407	23467	46514156
Prevertebral soft tissue swelling of cervical space	15.50	9.59	6	148433	48	46537575
Multiple allergies	15.36	9.59	55	148384	7316	46530307
Product prescribing error	15.35	9.59	25	148414	20022	46517601
Rhinovirus infection	15.33	9.59	35	148404	3601	46534022
Acute respiratory distress syndrome	15.28	9.59	29	148410	21893	46515730
Respiratory depression	15.19	9.59	9	148430	11591	46526032
Fracture	15.15	9.59	18	148421	16453	46521170
Mental status changes	15.05	9.59	66	148373	38022	46499601
Restrictive pulmonary disease	14.99	9.59	19	148420	1207	46536416
Bruxism	14.96	9.59	31	148408	2986	46534637
Bacterial test positive	14.89	9.59	39	148400	4377	46533246
Left ventricular dysfunction	14.84	9.59	7	148432	10248	46527375
Anuria	14.79	9.59	9	148430	11422	46526201
Acute hepatic failure	14.74	9.59	15	148424	14706	46522917
Encephalopathy	14.65	9.59	56	148383	33533	46504090
Hip fracture	14.56	9.59	40	148399	26516	46511107
Posterior reversible encephalopathy syndrome	14.52	9.59	16	148423	15125	46522498
Cells in urine	14.51	9.59	8	148431	153	46537470
Hyperplastic cholecystopathy	14.45	9.59	7	148432	101	46537522
Gamma-glutamyltransferase increased	14.45	9.59	52	148387	31688	46505935
Choluria	14.41	9.59	8	148431	155	46537468
Dyshidrotic eczema	14.36	9.59	12	148427	464	46537159
Exposure during pregnancy	14.36	9.59	448	147991	107764	46429859
Biliary dyskinesia	14.35	9.59	29	148410	2744	46534879
Hyperglycaemia	14.33	9.59	60	148379	35011	46502612
Haematuria	14.32	9.59	41	148398	26817	46510806
Reaction to excipient	14.30	9.59	18	148421	1136	46536487
Microcytosis	14.19	9.59	8	148431	160	46537463
Monocyte percentage increased	14.10	9.59	17	148422	1026	46536597
Pneumonitis	14.00	9.59	45	148394	28375	46509248
Asthenia	13.98	9.59	828	147611	310247	46227376
Cardiogenic shock	13.93	9.59	19	148420	16365	46521258
Mastoiditis	13.87	9.59	14	148425	692	46536931
Autoimmune arthritis	13.87	9.59	5	148434	32	46537591
Anaphylactic shock	13.79	9.59	111	148328	20163	46517460
Cerebral infarction	13.72	9.59	34	148405	23332	46514291
Gallbladder disorder	13.70	9.59	99	148340	17399	46520224
Bronchial neoplasm	13.67	9.59	9	148430	240	46537383
Weight decreased	13.65	9.59	540	147899	210309	46327314
Blood bilirubin increased	13.65	9.59	59	148380	34125	46503498
Upper gastrointestinal haemorrhage	13.65	9.59	20	148419	16718	46520905
Electrolyte imbalance	13.64	9.59	21	148418	17205	46520418
Loss of consciousness	13.64	9.59	252	148187	107986	46429637
Culture urine positive	13.60	9.59	32	148407	3359	46534264
Hepatotoxicity	13.46	9.59	38	148401	24971	46512652
Upper-airway cough syndrome	13.43	9.59	55	148384	7792	46529831
Tuberculosis	13.39	9.59	8	148431	10257	46527366
Pyrexia	13.36	9.59	942	147497	347860	46189763
Haematoma	13.35	9.59	54	148385	31818	46505805
Fungal endocarditis	13.35	9.59	9	148430	250	46537373
Pregnancy on contraceptive	13.29	9.59	17	148422	1090	46536533
Dermatitis contact	13.17	9.59	56	148383	8067	46529556
Cyanosis central	13.15	9.59	6	148433	75	46537548
Haematotoxicity	13.06	9.59	3	148436	6930	46530693
Histamine level increased	13.05	9.59	4	148435	14	46537609
Foot deformity	13.01	9.59	18	148421	15407	46522216
Specific gravity urine decreased	12.98	9.59	11	148428	434	46537189
Rectal haemorrhage	12.97	9.59	70	148369	38185	46499438
Breast cancer	12.96	9.59	88	148351	45430	46492193
Gait inability	12.73	9.59	63	148376	35140	46502483
Spinal cord paralysis	12.70	9.59	5	148434	42	46537581
Deficiency of bile secretion	12.63	9.59	4	148435	16	46537607
Oropharyngeal pain	12.62	9.59	317	148122	73851	46463772
Eosinophilic oesophagitis	12.50	9.59	8	148431	203	46537420
Cardiotoxicity	12.48	9.59	3	148436	6719	46530904
Psychotic disorder	12.45	9.59	34	148405	22587	46515036
Hypertensive crisis	12.39	9.59	15	148424	13600	46524023
Monocyte count abnormal	12.36	9.59	8	148431	207	46537416
Intentional product use issue	12.30	9.59	236	148203	52544	46485079
Infusion site swelling	12.28	9.59	43	148396	5656	46531967
Skin necrosis	12.26	9.59	6	148433	8598	46529025
Urticaria thermal	12.24	9.59	6	148433	89	46537534
Localised infection	12.21	9.59	37	148402	23764	46513859
CSF volume increased	12.19	9.59	3	148436	3	46537620
Pulmonary function test decreased	12.13	9.59	33	148406	3787	46533836
Urobilinogen urine increased	12.07	9.59	7	148432	148	46537475
Ear infection	12.05	9.59	119	148320	22894	46514729
Nasal polypectomy	11.91	9.59	4	148435	20	46537603
Neutrophil count decreased	11.85	9.59	85	148354	43341	46494282
Urine ketone body present	11.80	9.59	23	148416	2119	46535504
Colitis	11.76	9.59	70	148369	37277	46500346
Stress cardiomyopathy	11.75	9.59	5	148434	7779	46529844
Injury	11.71	9.59	201	148238	43826	46493797
Coordination abnormal	11.68	9.59	67	148372	10882	46526741
Intentional product misuse	11.56	9.59	95	148344	47033	46490590
Leukocytosis	11.56	9.59	37	148402	23361	46514262
Live birth	11.54	9.59	64	148375	10266	46527357
Fixed eruption	11.53	9.59	14	148425	851	46536772
Pain in extremity	11.53	9.59	689	147750	257991	46279632
Serotonin syndrome	11.48	9.59	39	148400	24181	46513442
Ovarian germ cell cancer stage II	11.44	9.59	5	148434	56	46537567
Alanine aminotransferase increased	11.44	9.59	205	148234	88246	46449377
Purpura senile	11.41	9.59	12	148427	623	46537000
Crying	11.40	9.59	110	148329	21031	46516592
Accidental exposure to product	11.37	9.59	32	148407	21049	46516574
Injection site urticaria	11.34	9.59	71	148368	11896	46525727
Blood potassium increased	11.34	9.59	23	148416	16944	46520679
Autophobia	11.31	9.59	4	148435	24	46537599
Nasal turbinate hypertrophy	11.29	9.59	10	148429	419	46537204
Dry mouth	11.28	9.59	241	148198	54685	46482938
Inflammation	11.22	9.59	100	148339	48681	46488942
Protrusion tongue	11.20	9.59	9	148430	329	46537294
Gastric ulcer	11.20	9.59	34	148405	21829	46515794
Intestinal perforation	10.93	9.59	11	148428	10840	46526783
Pelvi-ureteric obstruction	10.91	9.59	6	148433	114	46537509
Tachypnoea	10.89	9.59	18	148421	14333	46523290
Escherichia infection	10.86	9.59	11	148428	10806	46526817
Mean cell haemoglobin concentration increased	10.82	9.59	10	148429	443	46537180
Marginal zone lymphoma	10.79	9.59	4	148435	28	46537595
Myelodysplastic syndrome	10.76	9.59	21	148418	15690	46521933
White blood cell count decreased	10.75	9.59	273	148166	111958	46425665
Haematemesis	10.74	9.59	51	148388	28755	46508868
Foreign body in reproductive tract	10.72	9.59	8	148431	262	46537361
Dermatitis atopic	10.64	9.59	18	148421	1486	46536137
Ejection fraction decreased	10.61	9.59	26	148413	17911	46519712
Haemorrhage intracranial	10.58	9.59	15	148424	12709	46524914
Breast cancer metastatic	10.52	9.59	17	148422	13661	46523962
Klebsiella infection	10.52	9.59	4	148435	6658	46530965
Pancreatitis acute	10.51	9.59	42	148397	24830	46512793
Dialysis	10.48	9.59	10	148429	10106	46527517
Turner's syndrome	10.47	9.59	6	148433	124	46537499
Tonsillar hypertrophy	10.44	9.59	13	148426	811	46536812
Haematochezia	10.42	9.59	73	148366	37420	46500203
Bradypnoea	10.41	9.59	27	148412	3012	46534611
Renal injury	10.40	9.59	9	148430	9532	46528091
Amino acid level abnormal	10.39	9.59	3	148436	8	46537615
Bone disorder	10.38	9.59	31	148408	20002	46517621
Diffuse large B-cell lymphoma	10.36	9.59	3	148436	5935	46531688
Bacterial test	10.33	9.59	16	148423	1227	46536396
Second primary malignancy	10.32	9.59	4	148435	6580	46531043
Drug level decreased	10.29	9.59	3	148436	5909	46531714
Polyarthritis	10.21	9.59	4	148435	6538	46531085
Muscle rigidity	10.15	9.59	10	148429	9951	46527672
Amino acid level decreased	10.12	9.59	4	148435	34	46537589
Prosopagnosia	10.12	9.59	4	148435	34	46537589
Breast adenoma	10.12	9.59	4	148435	34	46537589
Drug use disorder	10.10	9.59	25	148414	2710	46534913
Akathisia	10.08	9.59	6	148433	7708	46529915
Conjunctivitis allergic	10.02	9.59	12	148427	719	46536904
Contusion	10.02	9.59	356	148083	87131	46450492
Myoclonus	9.99	9.59	19	148420	14333	46523290
Nitrite urine present	9.98	9.59	12	148427	722	46536901
Feelings of worthlessness	9.97	9.59	8	148431	292	46537331
Hypoxia	9.95	9.59	111	148328	51727	46485896
Cystic fibrosis	9.91	9.59	30	148409	3658	46533965
Allergic sinusitis	9.83	9.59	10	148429	499	46537124
Skin reaction	9.79	9.59	64	148375	10882	46526741
Diverticulum oesophageal	9.74	9.59	6	148433	142	46537481
Hyper IgE syndrome	9.74	9.59	7	148432	216	46537407
Corynebacterium test positive	9.73	9.59	4	148435	38	46537585
Premature labour	9.71	9.59	13	148426	11286	46526337
Aspartate aminotransferase increased	9.67	9.59	184	148255	78516	46459107
Blood pressure fluctuation	9.62	9.59	57	148382	30391	46507232
Pregnancy with injectable contraceptive	9.60	9.59	6	148433	146	46537477

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urticaria	297.26	10.35	394	46088	54212	29851784
Asthma	213.86	10.35	272	46210	35902	29870094
Pruritus	135.33	10.35	447	46035	117757	29788239
Sleep terror	110.17	10.35	42	46440	701	29905295
Death	81.93	10.35	283	46199	357000	29548996
Hypersensitivity	69.61	10.35	213	46269	53815	29852181
Sinusitis	68.01	10.35	156	46326	33189	29872807
Rash	65.41	10.35	515	45967	191374	29714622
Infective pulmonary exacerbation of cystic fibrosis	64.62	10.35	73	46409	8499	29897497
Wheezing	64.49	10.35	146	46336	30792	29875204
Vital capacity decreased	49.84	10.35	20	46462	385	29905611
Upper respiratory tract infection	48.96	10.35	122	46360	27354	29878642
Headache	47.34	10.35	461	46021	181845	29724151
Anaemia	44.68	10.35	169	46313	207823	29698173
Forced expiratory volume decreased	43.80	10.35	38	46444	3212	29902784
Sudden infant death syndrome	42.70	10.35	14	46468	146	29905850
Lip swelling	42.14	10.35	73	46409	12671	29893325
Migraine	41.60	10.35	73	46409	12801	29893195
Toxicity to various agents	39.32	10.35	142	46340	177041	29728955
General physical health deterioration	39.17	10.35	59	46423	99885	29806111
Angioedema	37.42	10.35	128	46354	34256	29871740
Pruritus genital	37.33	10.35	17	46465	451	29905545
Cough	36.73	10.35	326	46156	125316	29780680
Completed suicide	34.12	10.35	64	46418	99428	29806568
Dermatitis atopic	34.06	10.35	21	46461	1043	29904953
Nasal congestion	33.66	10.35	83	46399	18483	29887513
Oral pruritus	32.36	10.35	13	46469	251	29905745
Flushing	32.27	10.35	110	46372	29382	29876614
Suicidal ideation	32.18	10.35	126	46356	35988	29870008
Disturbance in attention	32.06	10.35	91	46391	22038	29883958
Fatigue	31.59	10.35	684	45798	319989	29586007
Swelling face	29.56	10.35	86	46396	21118	29884878
Renal failure	29.49	10.35	102	46380	128864	29777132
Multiple organ dysfunction syndrome	29.47	10.35	33	46449	63454	29842542
Interstitial lung disease	29.38	10.35	30	46452	60167	29845829
Myocardial infarction	28.97	10.35	99	46383	125526	29780470
Nasal oedema	28.93	10.35	13	46469	334	29905662
Renal impairment	28.12	10.35	55	46427	84129	29821867
Crystal urine present	28.05	10.35	12	46470	273	29905723
Differentiation syndrome	27.58	10.35	19	46463	1141	29904855
Acute kidney injury	27.54	10.35	282	46200	273560	29632436
Anaphylactic reaction	26.87	10.35	100	46382	27882	29878114
Rhinorrhoea	26.87	10.35	82	46400	20672	29885324
Ear infection	26.71	10.35	44	46438	7330	29898666
Penis injury	26.31	10.35	11	46471	236	29905760
Bone marrow failure	26.03	10.35	7	46475	29778	29876218
Anger	26.02	10.35	55	46427	11065	29894931
Throat irritation	25.73	10.35	47	46435	8501	29897495
Rash erythematous	25.67	10.35	85	46397	22367	29883629
Pulmonary function test decreased	24.88	10.35	32	46450	4263	29901733
Erythema	24.72	10.35	205	46277	77246	29828750
Penile haemorrhage	24.60	10.35	14	46468	599	29905397
Eczema	24.48	10.35	60	46422	13309	29892687
Hyperleukocytosis	24.11	10.35	20	46462	1589	29904407
Mydriasis	24.09	10.35	38	46444	6105	29899891
Victim of chemical submission	24.06	10.35	7	46475	47	29905949
Seasonal allergy	23.83	10.35	33	46449	4720	29901276
Rash pruritic	23.66	10.35	83	46399	22489	29883507
Throat tightness	23.52	10.35	41	46441	7151	29898845
Rheumatoid arthritis	23.14	10.35	18	46464	41179	29864817
Blood pressure increased	22.75	10.35	190	46292	71738	29834258
Nasal polyps	22.48	10.35	18	46464	1361	29904635
Sensorimotor disorder	21.70	10.35	11	46471	372	29905624
Mastocytosis	21.64	10.35	6	46476	33	29905963
Blister	21.63	10.35	76	46406	20607	29885389
Myocardial oedema	21.61	10.35	7	46475	70	29905926
Obstructive airways disorder	21.42	10.35	45	46437	9014	29896982
Cardio-respiratory arrest	21.32	10.35	35	46447	57271	29848725
Cardiac failure	21.13	10.35	63	46419	83355	29822641
Poverty of speech	21.11	10.35	9	46473	203	29905793
Infusion related reaction	21.05	10.35	121	46361	40443	29865553
Sinus disorder	21.03	10.35	36	46446	6189	29899807
Influenza	20.95	10.35	127	46355	43271	29862725
Chest discomfort	20.64	10.35	131	46351	45349	29860647
Malaise	20.00	10.35	367	46115	166595	29739401
Depressed mood	19.94	10.35	65	46417	16964	29889032
Respiratory muscle weakness	19.89	10.35	7	46475	92	29905904
Swollen tongue	19.84	10.35	55	46427	13137	29892859
Encephalopathy	19.49	10.35	13	46469	32192	29873804
Anxiety	19.36	10.35	219	46263	89652	29816344
Congenital genital malformation	19.33	10.35	5	46477	20	29905976
Malignant neoplasm progression	18.74	10.35	54	46428	72233	29833763
Oral allergy syndrome	18.43	10.35	5	46477	25	29905971
Mood altered	18.38	10.35	40	46442	8210	29897786
Tic	18.28	10.35	19	46463	2013	29903983
Cerebral dysgenesis	17.81	10.35	5	46477	29	29905967
Gastrointestinal haemorrhage	17.74	10.35	68	46414	83378	29822618
Gastric ulcer perforation	17.58	10.35	13	46469	873	29905123
Dry skin	17.36	10.35	75	46407	22379	29883617
Heart rate increased	17.24	10.35	111	46371	38610	29867386
Dystonia	17.12	10.35	43	46439	9684	29896312
Drug interaction	17.07	10.35	213	46269	199355	29706641
International normalised ratio increased	16.99	10.35	30	46452	47709	29858287
Brugada syndrome	16.96	10.35	11	46471	597	29905399
Peritonitis	16.92	10.35	6	46476	21369	29884627
Palpitations	16.68	10.35	99	46383	33474	29872522
Eye disorder	16.67	10.35	37	46445	7697	29898299
Micropenis	16.65	10.35	5	46477	38	29905958
Drug-induced liver injury	16.40	10.35	71	46411	21203	29884793
Disseminated intravascular coagulation	16.27	10.35	7	46475	22164	29883832
Pseudoporphyria	16.07	10.35	8	46474	260	29905736
Sleep apnoea syndrome	15.98	10.35	60	46422	16797	29889199
Cardiac failure congestive	15.94	10.35	72	46410	84335	29821661
Sepsis	15.40	10.35	149	46333	146246	29759750
Specific gravity urine increased	15.37	10.35	6	46476	107	29905889
Drug resistance	15.35	10.35	6	46476	20127	29885869
Increased upper airway secretion	15.32	10.35	16	46466	1704	29904292
Ascites	15.26	10.35	20	46462	35901	29870095
Disease progression	15.16	10.35	68	46414	79806	29826190
Reflux nephropathy	14.69	10.35	5	46477	59	29905937
Haemoglobin urine present	14.69	10.35	5	46477	59	29905937
Cardiogenic shock	14.66	10.35	4	46478	16857	29889139
Injection site swelling	14.61	10.35	38	46444	8742	29897254
Plasma cell myeloma	14.55	10.35	39	46443	53423	29852573
Bronchospasm	14.47	10.35	42	46440	10296	29895700
Lymphocyte percentage decreased	14.43	10.35	17	46465	2069	29903927
Hereditary angioedema	14.43	10.35	11	46471	774	29905222
Platelet count decreased	14.35	10.35	101	46381	106028	29799968
Abdominoplasty	14.34	10.35	3	46479	3	29905993
Lymphocyte count decreased	14.23	10.35	63	46419	18992	29887004
Cerebral infarction	14.21	10.35	12	46470	26361	29879635
Oropharyngeal pain	14.13	10.35	84	46398	28412	29877584
Middle insomnia	14.03	10.35	29	46453	5744	29900252
Conjunctivitis	13.70	10.35	35	46447	7965	29898031
Accident	13.69	10.35	22	46460	3591	29902405
Rhinitis	13.64	10.35	25	46457	4534	29901462
Aggression	13.59	10.35	101	46381	36806	29869190
Amino acid level increased	13.24	10.35	8	46474	383	29905613
Product quality issue	13.22	10.35	61	46421	18713	29887283
Periorbital discomfort	13.14	10.35	4	46478	32	29905964
Urine albumin/creatinine ratio	13.12	10.35	3	46479	6	29905990
Penile erythema	13.08	10.35	6	46476	162	29905834
Pharyngeal paraesthesia	13.05	10.35	8	46474	393	29905603
Hypercapnic coma	13.04	10.35	6	46476	163	29905833
Feeling hot	12.93	10.35	53	46429	15451	29890545
Urethritis noninfective	12.81	10.35	3	46479	7	29905989
Rhabdomyolysis	12.75	10.35	53	46429	63527	29842469
Cardiac arrest	12.73	10.35	88	46394	92762	29813234
Infusion site pain	12.69	10.35	18	46464	2632	29903364
Hypertrichosis	12.68	10.35	7	46475	282	29905714
Seizure	12.67	10.35	219	46263	98256	29807740
Neutrophil percentage increased	12.58	10.35	15	46467	1849	29904147
Urine analysis abnormal	12.56	10.35	15	46467	1853	29904143
Blood creatinine increased	12.33	10.35	87	46395	91288	29814708
Infusion site pruritus	12.32	10.35	9	46473	593	29905403
Acquired haemophilia	12.25	10.35	10	46472	777	29905219
Psychomotor hyperactivity	12.08	10.35	34	46448	8190	29897806
Adenoidal hypertrophy	12.01	10.35	5	46477	106	29905890
Pancytopenia	11.96	10.35	80	46402	84972	29821024
Viral infection	11.95	10.35	51	46431	15134	29890862
Blood creatine phosphokinase increased	11.92	10.35	32	46450	43816	29862180
Affective disorder	11.87	10.35	19	46463	3089	29902907
Hepatic function abnormal	11.87	10.35	30	46452	41915	29864081
Pleural effusion	11.80	10.35	67	46415	73999	29831997
Shock	11.60	10.35	11	46471	22848	29883148
Tendon disorder	11.60	10.35	16	46466	2280	29903716
Complex regional pain syndrome	11.51	10.35	8	46474	487	29905509
Sinus operation	11.51	10.35	9	46473	657	29905339
Swelling	11.35	10.35	95	46387	35880	29870116
Ileus	11.27	10.35	5	46477	15550	29890446
Attention deficit hyperactivity disorder	11.21	10.35	14	46468	1810	29904186
Crying	11.16	10.35	26	46456	5583	29900413
Dermatitis exfoliative	11.13	10.35	31	46451	7425	29898571
Drug reaction with eosinophilia and systemic symptoms	11.08	10.35	79	46403	28409	29877587
Temperature intolerance	11.02	10.35	18	46464	2977	29903019
Exposure to toxic agent	10.99	10.35	11	46471	1114	29904882
Somnolence	10.97	10.35	211	46271	96552	29809444
Eye movement disorder	10.92	10.35	21	46461	3947	29902049
Infusion site swelling	10.90	10.35	13	46469	1603	29904393
Forced expiratory volume increased	10.90	10.35	3	46479	16	29905980
C-reactive protein increased	10.88	10.35	33	46449	43440	29862556
Oculogyric crisis	10.86	10.35	12	46470	1363	29904633
Tongue ulceration	10.86	10.35	11	46471	1131	29904865
Adenocarcinoma pancreas	10.84	10.35	12	46470	1366	29904630
Irritability	10.83	10.35	67	46415	22983	29883013
Violence-related symptom	10.80	10.35	8	46474	539	29905457
Respiratory failure	10.76	10.35	102	46380	100540	29805456
Erythema multiforme	10.76	10.35	32	46450	7953	29898043
Rash macular	10.75	10.35	38	46444	10329	29895667
Enlarged uvula	10.73	10.35	5	46477	140	29905856
Pharyngitis streptococcal	10.67	10.35	14	46468	1901	29904095
Croup infectious	10.64	10.35	6	46476	252	29905744
Respiratory tract infection	10.64	10.35	50	46432	15456	29890540
Growth accelerated	10.60	10.35	3	46479	18	29905978
Patient uncooperative	10.57	10.35	5	46477	145	29905851
Leukopenia	10.54	10.35	48	46434	56111	29849885
Fixed eruption	10.52	10.35	11	46471	1173	29904823
Meningioma	10.39	10.35	12	46470	1431	29904565

Pharmacologic Action:

Source	Code	Description
ATC	R06AE07	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Piperazine derivatives
FDA MoA	N0000000190	Histamine H1 Receptor Antagonists
FDA EPC	N0000175587	Histamine-1 Receptor Antagonist
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:37955	h1-receptor blockers
CHEBI has role	CHEBI:50857	anti-allergic agents
CHEBI has role	CHEBI:78298	environmental contaminants
MeSH PA	D018926	Anti-Allergic Agents
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D039563	Histamine H1 Antagonists, Non-Sedating
MeSH PA	D018377	Neurotransmitter Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Vasomotor rhinitis	indication	8229003	DOID:4730
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Sneezing	indication	76067001
Common cold	indication	82272006	DOID:10459
Chronic idiopathic urticaria	indication	302162004
Seasonal allergic rhinitis	indication	367498001
Allergic conjunctivitis	indication	473460002	DOID:11204
Atopic dermatitis	off-label use	24079001	DOID:3310
Urticaria	off-label use	126485001
Glaucoma	contraindication	23986001	DOID:1686
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Diabetes mellitus	contraindication	73211009	DOID:9351
Chronic renal failure syndrome	contraindication	90688005
Kidney disease	contraindication	90708001	DOID:557
Disease of liver	contraindication	235856003	DOID:409
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Drowsy	contraindication	271782001
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Hypertensive urgency	contraindication	443482000
Hemodialysis with High-Flux Membrane	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.03	acidic
pKa2	8.21	Basic
pKa3	3.72	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
10MG/ML (10MG/ML)	QUZYTTIR	JDP	N211415	Oct. 4, 2019	RX	SOLUTION	INTRAVENOUS	Oct. 4, 2022	NEW PRODUCT

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	7.91		WOMBAT-PK	CHEMBL
Angiopoietin-1 receptor	Kinase	Q02763	TIE2_HUMAN		Kd	4.05		CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	4.52		CHEMBL

External reference:

ID	Source
4024005	VUID
N0000022010	NUI
D00664	KEGG_DRUG
83881-52-1	SECONDARY_CAS_RN
4020943	VANDF
4024005	VANDF
C0055147	UMLSCUI
CHEBI:3561	CHEBI
CHEMBL1000	ChEMBL_ID
CHEMBL1607273	ChEMBL_ID
CHEMBL1201113	ChEMBL_ID
DB00341	DRUGBANK_ID
D017332	MESH_DESCRIPTOR_UI
2678	PUBCHEM_CID
1222	IUPHAR_LIGAND_ID
5520	INN_ID
YO7261ME24	UNII
203150	RXNORM
130140	MMSL
38293	MMSL
4399	MMSL
4400	MMSL
d03827	MMSL
003803	NDDF
003804	NDDF
108655000	SNOMEDCT_US
108656004	SNOMEDCT_US
372523007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
good sense all day allergy d	HUMAN OTC DRUG LABEL	2	0113-0147	TABLET, FILM COATED, EXTENDED RELEASE	5 mg	ORAL	ANDA	16 sections
Good Sense All Day Allergy D	HUMAN OTC DRUG LABEL	2	0113-0176	TABLET, EXTENDED RELEASE	5 mg	ORAL	ANDA	16 sections
Good Sense Childrens All Day Allergy	HUMAN OTC DRUG LABEL	1	0113-0189	SOLUTION	5 mg	ORAL	ANDA	16 sections
Good Sense Childrens All Day Allergy	HUMAN OTC DRUG LABEL	1	0113-0503	SOLUTION	5 mg	ORAL	ANDA	16 sections
good sense all day allergy	HUMAN OTC DRUG LABEL	1	0113-1036	CAPSULE, LIQUID FILLED	10 mg	ORAL	ANDA	16 sections
All Day Allergy-D	HUMAN OTC DRUG LABEL	2	0113-2176	TABLET, EXTENDED RELEASE	5 mg	ORAL	ANDA	16 sections
Basic Care All Day Allergy	HUMAN OTC DRUG LABEL	1	0113-7002	TABLET, FILM COATED	10 mg	ORAL	ANDA	16 sections
BASIC CARE ALL DAY ALLERGY	HUMAN OTC DRUG LABEL	1	0113-7036	CAPSULE, LIQUID FILLED	10 mg	ORAL	ANDA	16 sections
basic care childrens all day allergy	HUMAN OTC DRUG LABEL	1	0113-7189	SOLUTION	5 mg	ORAL	ANDA	16 sections
basic care childrens all day allergy	HUMAN OTC DRUG LABEL	1	0113-7475	SOLUTION	5 mg	ORAL	ANDA	16 sections
Good Sense all day allergy	HUMAN OTC DRUG LABEL	1	0113-9458	TABLET, FILM COATED	10 mg	ORAL	ANDA	16 sections
Cetirizine Hydrochloride	HUMAN OTC DRUG LABEL	1	0121-4780	SYRUP	5 mg	ORAL	ANDA	17 sections
Cetirizine Hydrochloride (Allergy)	Human OTC Drug Label	1	0363-0068	CAPSULE	10 mg	ORAL	ANDA	16 sections
Cetirizine Hydrochloride	Human OTC Drug Label	1	0363-0471	TABLET, ORALLY DISINTEGRATING	10 mg	ORAL	ANDA	14 sections
Wal Zyr	HUMAN OTC DRUG LABEL	1	0363-0495	TABLET, FILM COATED	10 mg	ORAL	ANDA	16 sections
Wal-Zyr	HUMAN OTC DRUG LABEL	1	0363-0606	TABLET	10 mg	ORAL	ANDA	17 sections
Wal-Zyr	HUMAN OTC DRUG LABEL	1	0363-0741	CAPSULE	10 mg	ORAL	ANDA	16 sections
Wal-Zyr	HUMAN OTC DRUG LABEL	1	0363-0921	CAPSULE	10 mg	ORAL	NDA	17 sections
Childrens Dye Free Wal Zyr	HUMAN OTC DRUG LABEL	1	0363-0953	SOLUTION	5 mg	ORAL	ANDA	16 sections
Wal-Zyr D	HUMAN OTC DRUG LABEL	2	0363-0989	TABLET, FILM COATED, EXTENDED RELEASE	5 mg	ORAL	ANDA	17 sections
Cetirizine	HUMAN OTC DRUG LABEL	1	0363-1040	CAPSULE, LIQUID FILLED	10 mg	ORAL	ANDA	16 sections
WAL ZYR D	HUMAN OTC DRUG LABEL	2	0363-1147	TABLET, FILM COATED, EXTENDED RELEASE	5 mg	ORAL	ANDA	16 sections
24 Hour Allergy	HUMAN OTC DRUG LABEL	1	0363-1219	CAPSULE	10 mg	ORAL	NDA	17 sections
childrens dye free wal zyr	HUMAN OTC DRUG LABEL	1	0363-1475	SOLUTION	5 mg	ORAL	ANDA	16 sections
Wal-Zyr Cetirizine Hydrochloride	HUMAN OTC DRUG LABEL	1	0363-2088	SOLUTION	5 mg	ORAL	ANDA	17 sections
Wal-Zyr Cetirizine Hydrochloride	HUMAN OTC DRUG LABEL	1	0363-2102	SOLUTION	5 mg	ORAL	ANDA	17 sections
Wal-Zyr All Day Allergy	HUMAN OTC DRUG LABEL	1	0363-2106	SOLUTION	5 mg	ORAL	ANDA	17 sections
Childrens Cetirizine Hydrochloride	Human OTC Drug Label	1	0363-4025	TABLET, ORALLY DISINTEGRATING	10 mg	ORAL	ANDA	14 sections
Cetirizine Hydrochloride	HUMAN OTC DRUG LABEL	1	0363-9899	TABLET	10 mg	ORAL	ANDA	15 sections
Cetirizine Hydrochloride	HUMAN OTC DRUG LABEL	1	0378-3635	TABLET, FILM COATED	5 mg	ORAL	ANDA	16 sections