cetirizine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diphenylmethyl piperazine derivatives 581 83881-51-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cetirizine
  • cetirizine hydrochloride
  • cetirizine dihydrochloride
  • cetirizine HCl
A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
  • Molecular weight: 388.89
  • Formula: C21H25ClN2O3
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 53.01
  • ALOGS: -3.77
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 5 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.37 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 8, 1995 FDA J AND J CONSUMER INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 3062.39 10.69 4344 340231 179382 62965065
Systemic lupus erythematosus 2728.03 10.69 4409 340166 204509 62939938
Glossodynia 2642.16 10.69 3996 340579 174880 62969567
Hand deformity 1985.60 10.69 3296 341279 156161 62988286
Abdominal discomfort 1842.18 10.69 4820 339755 316065 62828382
Alopecia 1837.68 10.69 4971 339604 332565 62811882
Wound 1732.49 10.69 3145 341430 160118 62984329
Swelling 1707.81 10.69 4260 340315 271118 62873329
Pericarditis 1509.01 10.69 2623 341952 128956 63015491
Discomfort 1417.98 10.69 2932 341643 164442 62980005
Contraindicated product administered 1394.65 10.69 3411 341164 214237 62930210
Anti-cyclic citrullinated peptide antibody positive 1328.75 10.69 2314 342261 113898 63030549
Arthropathy 1244.37 10.69 3427 341148 231365 62913082
Hypersensitivity 1116.21 10.69 3807 340768 288878 62855569
Duodenal ulcer perforation 963.31 10.69 1711 342864 85498 63058949
Maternal exposure during pregnancy 929.02 10.69 2964 341611 217098 62927349
Infusion related reaction 924.37 10.69 3181 341394 242340 62902107
Helicobacter infection 918.27 10.69 1736 342839 91049 63053398
Synovitis 902.30 10.69 2639 341936 184279 62960168
Folliculitis 850.18 10.69 1436 343139 68881 63075566
Muscle injury 847.12 10.69 1377 343198 63968 63080479
Blister 831.72 10.69 2036 342539 127778 63016669
Death 818.90 10.69 511 344064 373870 62770577
Hepatic enzyme increased 814.74 10.69 2682 341893 199646 62944801
Pain 799.60 10.69 6788 337787 733840 62410607
Irritable bowel syndrome 770.03 10.69 1505 343070 80907 63063540
Product use issue 682.11 10.69 2682 341893 217838 62926609
Rheumatoid factor positive 650.47 10.69 1424 343151 82982 63061465
Rash 637.50 10.69 5204 339371 555667 62588780
Acute kidney injury 605.93 10.69 338 344237 263077 62881370
Toxicity to various agents 592.57 10.69 301 344274 246949 62897498
Sleep disorder due to general medical condition, insomnia type 556.45 10.69 1009 343566 51208 63093239
Lower respiratory tract infection 553.78 10.69 1778 342797 130529 63013918
Pruritus 553.70 10.69 3604 340971 357849 62786598
Anaemia 552.03 10.69 469 344106 292961 62851486
Urticaria 532.25 10.69 2041 342534 163761 62980686
Drug intolerance 529.00 10.69 3168 341407 305493 62838954
Impaired healing 516.53 10.69 1471 343104 101071 63043376
Joint swelling 516.32 10.69 3291 341284 324375 62820072
Therapeutic product effect decreased 512.53 10.69 2242 342333 190945 62953502
Sinusitis 459.26 10.69 2434 342141 224219 62920228
Ill-defined disorder 454.49 10.69 1216 343359 80539 63063908
Drug interaction 435.96 10.69 362 344213 228769 62915678
Rheumatic fever 429.08 10.69 809 343766 42302 63102145
Fatigue 426.32 10.69 6966 337609 881062 62263385
Fall 424.41 10.69 938 343637 391396 62753051
Completed suicide 400.29 10.69 145 344430 145528 62998919
Neutropenia 379.02 10.69 241 344334 174764 62969683
Hypotension 378.64 10.69 558 344017 272046 62872401
Swollen joint count increased 371.81 10.69 687 343888 35367 63109080
Hip arthroplasty 356.87 10.69 795 343780 46851 63097596
Stomatitis 317.99 10.69 1543 343032 137182 63007265
Gastrointestinal disorder 316.97 10.69 1482 343093 129757 63014690
Type 2 diabetes mellitus 313.48 10.69 908 343667 62960 63081487
Knee arthroplasty 309.01 10.69 814 343761 53392 63091055
Liver injury 276.65 10.69 839 343736 59681 63084766
Sepsis 271.74 10.69 258 344317 152865 62991582
Thrombocytopenia 264.38 10.69 258 344317 150899 62993548
Rheumatoid arthritis 263.99 10.69 2312 342263 251507 62892940
Pneumonia 262.20 10.69 1433 343142 455334 62689113
Treatment failure 245.63 10.69 1885 342690 197158 62947289
Diarrhoea 241.59 10.69 2602 341973 712764 62431683
Blood cholesterol increased 238.92 10.69 1078 343497 92954 63051493
Malignant neoplasm progression 237.24 10.69 75 344500 82046 63062401
Hyponatraemia 235.53 10.69 159 344416 111741 63032706
Febrile neutropenia 235.31 10.69 179 344396 118270 63026177
Disease progression 234.45 10.69 193 344382 122565 63021882
Dermatitis atopic 226.86 10.69 272 344303 9452 63134995
Nausea 216.26 10.69 3303 341272 851168 62293279
Haemoglobin decreased 206.49 10.69 293 344282 145192 62999255
Pancytopenia 206.33 10.69 136 344439 96797 63047650
Urinary tract infection 204.38 10.69 743 343832 263941 62880506
Psoriatic arthropathy 197.53 10.69 1001 343574 90519 63053928
Cardiac failure 196.69 10.69 120 344455 89022 63055425
Asthma 194.57 10.69 1272 343303 126289 63018158
Food allergy 182.40 10.69 265 344310 11136 63133311
Renal failure 179.09 10.69 225 344350 117427 63027020
Renal impairment 177.43 10.69 132 344443 88223 63056224
Atrial fibrillation 176.56 10.69 224 344351 116412 63028035
Gastrointestinal haemorrhage 172.61 10.69 114 344461 81062 63063385
Nasopharyngitis 168.44 10.69 2114 342461 252143 62892304
Depressed level of consciousness 166.72 10.69 64 344511 62014 63082433
Cardio-respiratory arrest 164.07 10.69 60 344515 59899 63084548
Blood creatinine increased 162.93 10.69 142 344433 87702 63056745
Cardiac failure congestive 162.45 10.69 157 344418 92276 63052171
Respiratory failure 162.24 10.69 188 344387 101670 63042777
Leukopenia 161.04 10.69 111 344464 77179 63067268
Intentional product use issue 160.31 10.69 1216 343359 126676 63017771
Septic shock 158.05 10.69 82 344493 66547 63077900
Dehydration 157.83 10.69 452 344123 172902 62971545
Platelet count decreased 157.78 10.69 241 344334 115881 63028566
Contusion 155.89 10.69 1367 343208 148677 62995770
Infection 153.28 10.69 1909 342666 227264 62917183
Metabolic acidosis 151.72 10.69 30 344545 45039 63099408
Temperature regulation disorder 142.18 10.69 171 344404 5961 63138486
Multiple organ dysfunction syndrome 141.97 10.69 65 344510 56687 63087760
Hypokalaemia 136.68 10.69 220 344355 103584 63040863
Cerebrovascular accident 134.80 10.69 237 344338 107787 63036660
Interstitial lung disease 132.89 10.69 86 344489 61822 63082625
White blood cell count decreased 132.33 10.69 355 344220 138749 63005698
Angioedema 130.96 10.69 562 344013 47403 63097044
Coeliac disease 130.83 10.69 243 344332 12554 63131893
Peripheral swelling 130.66 10.69 2098 342477 263844 62880603
Cardiac arrest 130.65 10.69 187 344388 92358 63052089
Vomiting 126.84 10.69 2206 342369 557411 62587036
Prescribed overdose 125.82 10.69 440 344135 33713 63110734
Myocardial infarction 125.70 10.69 218 344357 99675 63044772
Coma 123.09 10.69 101 344474 64263 63080184
Seizure 119.11 10.69 348 344227 132286 63012161
Weight increased 118.38 10.69 2031 342544 258761 62885686
Intentional overdose 117.92 10.69 137 344438 74015 63070432
Pleural effusion 117.66 10.69 203 344372 93007 63051440
Haemorrhage 117.63 10.69 95 344480 60927 63083520
International normalised ratio increased 113.31 10.69 55 344520 46370 63098077
Asthenia 112.42 10.69 1438 343137 382166 62762281
Injury 104.75 10.69 719 343856 72528 63071919
Rhabdomyolysis 102.89 10.69 55 344520 43896 63100551
Hyperkalaemia 101.25 10.69 87 344488 54116 63090331
Overdose 98.97 10.69 308 344267 114770 63029677
Lactic acidosis 98.68 10.69 42 344533 38245 63106202
Oedema peripheral 98.54 10.69 613 343962 188898 62955549
Premature delivery 98.13 10.69 22 344553 30259 63114188
Liver function test abnormal 94.13 10.69 74 344501 48107 63096340
Hypoglycaemia 92.28 10.69 114 344461 59951 63084496
Drug resistance 91.84 10.69 9 344566 22924 63121523
Herpes zoster 91.47 10.69 194 344381 82268 63062179
Sleep disorder 91.43 10.69 756 343819 80810 63063637
Mucosal inflammation 90.52 10.69 73 344502 46855 63097592
Night sweats 90.36 10.69 512 344063 48302 63096145
Pain in extremity 90.02 10.69 1262 343313 330224 62814223
Somnolence 89.81 10.69 584 343991 178101 62966346
Drug abuse 89.64 10.69 160 344415 72358 63072089
Bone marrow failure 89.62 10.69 24 344551 29266 63115181
Hypercalcaemia 88.97 10.69 22 344553 28300 63116147
Loss of consciousness 88.79 10.69 335 344240 117786 63026661
Skin ulcer 88.10 10.69 63 344512 42982 63101465
Macular degeneration 87.17 10.69 311 344264 24065 63120382
Wheezing 87.13 10.69 847 343728 94748 63049699
Pulmonary embolism 87.01 10.69 332 344243 116352 63028095
Weight decreased 86.92 10.69 1022 343553 275776 62868671
Chronic kidney disease 84.63 10.69 73 344502 45325 63099122
Constipation 82.95 10.69 800 343775 224143 62920304
Alanine aminotransferase increased 81.48 10.69 289 344286 103481 63040966
Cellulitis 81.09 10.69 205 344370 81753 63062694
Pneumonia aspiration 79.72 10.69 44 344531 34496 63109951
Hepatic function abnormal 79.16 10.69 52 344523 37090 63107357
Confusional state 77.83 10.69 1754 342821 234626 62909821
Ascites 77.75 10.69 64 344511 40664 63103783
Cytomegalovirus infection 77.04 10.69 11 344564 20941 63123506
Electric shock 76.82 10.69 61 344514 1259 63143188
Femur fracture 75.61 10.69 69 344506 41687 63102760
Off label use 75.52 10.69 2946 341629 671516 62472931
Altered state of consciousness 74.73 10.69 22 344553 25208 63119239
Pulmonary oedema 74.39 10.69 114 344461 54759 63089688
Shock 74.14 10.69 18 344557 23445 63121002
Unresponsive to stimuli 73.91 10.69 46 344529 33770 63110677
Melaena 72.55 10.69 37 344538 30328 63114119
Bursitis 72.20 10.69 394 344181 36647 63107800
Myelosuppression 71.44 10.69 20 344555 23683 63120764
Hepatotoxicity 70.97 10.69 58 344517 36983 63107464
Drug level increased 70.76 10.69 18 344557 22718 63121729
Rheumatoid nodule 70.67 10.69 6 344569 17149 63127298
Hepatic failure 70.62 10.69 54 344521 35602 63108845
Adjustment disorder with depressed mood 70.53 10.69 165 344410 10039 63134408
Neutrophil count decreased 70.12 10.69 124 344451 56282 63088165
Aspartate aminotransferase increased 69.83 10.69 253 344322 90024 63054423
Osteonecrosis of jaw 69.81 10.69 53 344522 35070 63109377
Ear pain 69.61 10.69 383 344192 35735 63108712
Electrocardiogram QT prolonged 69.46 10.69 136 344439 59394 63085053
Hypoxia 69.42 10.69 137 344438 59655 63084792
Fibromyalgia 68.65 10.69 703 343872 79717 63064730
Neoplasm progression 68.61 10.69 58 344517 36370 63108077
Tremor 68.58 10.69 428 344147 131811 63012636
Muscle spasticity 67.89 10.69 266 344309 21528 63122919
Neuropathy peripheral 67.51 10.69 352 344223 113315 63031132
Adverse event 66.74 10.69 609 343966 66950 63077497
Encephalopathy 66.22 10.69 67 344508 38553 63105894
Live birth 65.91 10.69 295 344280 25335 63119112
Hypomagnesaemia 65.75 10.69 37 344538 28700 63115747
Pericardial effusion 65.54 10.69 41 344534 30017 63114430
Pneumonitis 65.21 10.69 57 344518 35165 63109282
Thrombosis 64.81 10.69 161 344414 64594 63079853
Urticaria chronic 64.69 10.69 42 344533 623 63143824
Blood creatine phosphokinase increased 64.31 10.69 43 344532 30387 63114060
Respiratory arrest 63.94 10.69 50 344525 32595 63111852
Acute myeloid leukaemia 63.05 10.69 9 344566 17138 63127309
Myalgia 62.89 10.69 501 344074 146028 62998419
Transaminases increased 62.77 10.69 47 344528 31320 63113127
Serotonin syndrome 62.70 10.69 39 344536 28643 63115804
Mental status changes 62.05 10.69 74 344501 39525 63104922
Acute myocardial infarction 61.92 10.69 50 344525 32074 63112373
Orthostatic hypotension 61.69 10.69 63 344512 36097 63108350
Hyperglycaemia 61.68 10.69 82 344493 41785 63102662
Cerebral haemorrhage 61.55 10.69 46 344529 30683 63113764
Product prescribing error 61.38 10.69 33 344542 26256 63118191
Crystal urine present 61.07 10.69 59 344516 1595 63142852
Blood bilirubin increased 60.80 10.69 67 344508 37073 63107374
Plasma cell myeloma 60.75 10.69 63 344512 35842 63108605
Blood pressure increased 59.44 10.69 577 343998 161485 62982962
Urinary sediment present 58.71 10.69 66 344509 2137 63142310
Respiratory disorder 58.47 10.69 388 344187 38694 63105753
Premature baby 58.00 10.69 20 344555 20715 63123732
Proteinuria 57.98 10.69 16 344559 19129 63125318
Musculoskeletal stiffness 57.96 10.69 1361 343214 183257 62961190
Neurotoxicity 57.83 10.69 11 344564 16979 63127468
Foetal exposure during pregnancy 57.65 10.69 53 344522 31909 63112538
Disseminated intravascular coagulation 57.55 10.69 16 344559 19035 63125412
Bradycardia 56.77 10.69 205 344370 73022 63071425
Lip dry 56.71 10.69 199 344376 15271 63129176
Hip fracture 56.65 10.69 46 344529 29428 63115019
Palmar-plantar erythrodysaesthesia syndrome 56.57 10.69 27 344548 22988 63121459
Lung neoplasm malignant 56.56 10.69 18 344557 19615 63124832
Fracture 56.34 10.69 18 344557 19566 63124881
Syncope 56.27 10.69 389 344186 116996 63027451
Autoimmune disorder 56.24 10.69 213 344362 16964 63127483
Deep vein thrombosis postoperative 56.09 10.69 162 344413 11207 63133240
Abdominal pain 56.07 10.69 1190 343385 292266 62852181
Osteomyelitis 56.03 10.69 36 344539 25984 63118463
Haematuria 55.43 10.69 46 344529 29111 63115336
Haematochezia 55.26 10.69 131 344444 53413 63091034
Breast cancer 55.19 10.69 112 344463 48271 63096176
Creatinine renal clearance decreased 54.58 10.69 11 344564 16297 63128150
General physical health deterioration 54.41 10.69 1455 343120 199947 62944500
Blood lactate dehydrogenase increased 54.00 10.69 29 344546 23087 63121360
Dislocation of vertebra 53.65 10.69 134 344441 8501 63135946
Adverse drug reaction 53.16 10.69 664 343911 79050 63065397
Blood pressure fluctuation 53.02 10.69 107 344468 46210 63098237
Gamma-glutamyltransferase increased 52.89 10.69 64 344511 33967 63110480
Facet joint syndrome 52.39 10.69 165 344410 11973 63132474
Exposure during pregnancy 52.34 10.69 1158 343417 154389 62990058
Drug ineffective 52.34 10.69 6451 338124 1038314 62106133
Neoplasm malignant 52.12 10.69 51 344524 29810 63114637
Immunodeficiency 51.99 10.69 233 344342 20021 63124426
Anti-cyclic citrullinated peptide antibody 51.97 10.69 114 344461 6644 63137803
Retinitis 51.65 10.69 108 344467 6088 63138359
Bacteraemia 51.61 10.69 15 344560 17333 63127114
Pulmonary hypertension 51.41 10.69 76 344499 37047 63107400
Osteonecrosis 51.39 10.69 35 344540 24495 63119952
Agitation 51.31 10.69 160 344415 59597 63084850
Anticipatory anxiety 50.73 10.69 47 344528 1204 63143243
Peritonitis 50.73 10.69 15 344560 17139 63127308
Cataract 50.24 10.69 151 344424 56902 63087545
Hypocalcaemia 49.97 10.69 59 344516 31654 63112793
Blood calcium decreased 49.95 10.69 42 344533 26409 63118038
Agranulocytosis 49.86 10.69 38 344537 25096 63119351
Posterior reversible encephalopathy syndrome 49.79 10.69 16 344559 17329 63127118
Skin necrosis 49.74 10.69 8 344567 13942 63130505
Decreased appetite 49.73 10.69 1012 343563 250040 62894407
Renal tubular necrosis 49.35 10.69 4 344571 11874 63132573
Acute hepatic failure 49.02 10.69 19 344556 18308 63126139
Eye pruritus 48.84 10.69 216 344359 18455 63125992
Sedation 48.52 10.69 85 344490 38724 63105723
Cardiac disorder 48.05 10.69 130 344445 50686 63093761
Metastases to central nervous system 47.90 10.69 7 344568 13098 63131349
Metastases to liver 47.84 10.69 35 344540 23604 63120843
Localised infection 47.82 10.69 56 344519 30154 63114293
Deep vein thrombosis 47.81 10.69 263 344312 83537 63060910
Pain in jaw 47.67 10.69 103 344472 43393 63101054
Cerebral infarction 47.55 10.69 36 344539 23857 63120590
Body temperature increased 47.31 10.69 355 344220 36837 63107610
Cardiospasm 47.22 10.69 55 344520 1852 63142595
Electrolyte imbalance 47.17 10.69 25 344550 20051 63124396
Product dose omission issue 47.16 10.69 942 343633 233371 62911076
Psychotic disorder 45.94 10.69 43 344532 25669 63118778
Rectal haemorrhage 45.93 10.69 126 344449 48904 63095543
Haemoglobin urine present 45.70 10.69 37 344538 786 63143661
Blood immunoglobulin E increased 45.66 10.69 78 344497 3771 63140676
Arthralgia 45.54 10.69 3635 340940 566075 62578372
Hypophagia 45.26 10.69 62 344513 31197 63113250
Upper gastrointestinal haemorrhage 45.00 10.69 23 344552 18829 63125618
Epistaxis 44.99 10.69 222 344353 72503 63071944
Palmoplantar keratoderma 44.95 10.69 55 344520 1952 63142495
Acute respiratory distress syndrome 44.90 10.69 37 344538 23497 63120950
Urine leukocyte esterase positive 44.41 10.69 74 344501 3505 63140942
Extrapyramidal disorder 44.38 10.69 9 344566 13275 63131172
Pruritus genital 44.37 10.69 63 344512 2591 63141856
Respiratory depression 44.37 10.69 10 344565 13705 63130742
Vocal cord dysfunction 44.18 10.69 31 344544 526 63143921
Basal cell carcinoma 44.18 10.69 52 344523 27939 63116508
Accidental overdose 44.03 10.69 37 344538 23272 63121175
Cystitis 43.93 10.69 152 344423 54839 63089608
Haematoma 43.77 10.69 76 344499 34744 63109703
Hereditary angioedema 43.51 10.69 114 344461 7448 63136999
Haematemesis 43.35 10.69 61 344514 30351 63114096
Accidental exposure to product 43.16 10.69 51 344524 27354 63117093
Colitis 43.04 10.69 128 344447 48400 63096047
Wrong technique in product usage process 42.91 10.69 183 344392 62157 63082290
Lymphocyte percentage decreased 42.91 10.69 66 344509 2919 63141528
Cardiomyopathy 42.65 10.69 21 344554 17563 63126884
Generalised tonic-clonic seizure 42.57 10.69 57 344518 28959 63115488
Renal disorder 42.34 10.69 71 344504 32903 63111544
Leukocytosis 42.22 10.69 47 344528 25888 63118559
Acute respiratory failure 41.79 10.69 77 344498 34408 63110039
Blood parathyroid hormone decreased 41.52 10.69 3 344572 9788 63134659
Tachycardia 41.51 10.69 425 344150 117731 63026716
Diabetes mellitus 41.45 10.69 159 344416 55651 63088796
Bone disorder 41.34 10.69 33 344542 21293 63123154
Drug tolerance decreased 41.15 10.69 196 344379 17277 63127170
Cholestasis 41.01 10.69 60 344515 29374 63115073
Labelled drug-drug interaction medication error 40.95 10.69 11 344564 13388 63131059
Blood pressure diastolic abnormal 40.72 10.69 14 344561 14528 63129919
Blood pressure systolic increased 40.62 10.69 127 344448 47270 63097177
Anaphylactic reaction 40.45 10.69 542 344033 65558 63078889
Lupus vulgaris 40.42 10.69 96 344479 5898 63138549
Metastases to bone 40.15 10.69 33 344542 20986 63123461
Thrombotic microangiopathy 40.13 10.69 5 344570 10556 63133891
Maternal exposure timing unspecified 39.93 10.69 106 344469 6981 63137466
Gastric ulcer 39.74 10.69 43 344532 23994 63120453
Pancreatitis 39.58 10.69 135 344440 48920 63095527
Sleep terror 39.57 10.69 60 344515 2620 63141827
Urine abnormality 39.56 10.69 105 344470 6914 63137533
Panniculitis 39.55 10.69 7 344568 11378 63133069
Therapeutic product effect incomplete 39.47 10.69 461 344114 124595 63019852
Haematotoxicity 39.40 10.69 3 344572 9373 63135074
Shock haemorrhagic 39.32 10.69 4 344571 9891 63134556
Pancreatitis acute 39.21 10.69 54 344521 27112 63117335
Hypothyroidism 38.87 10.69 111 344464 42521 63101926
Therapy interrupted 38.86 10.69 73 344502 32382 63112065
Transplant rejection 38.85 10.69 6 344569 10774 63133673
Suicide attempt 38.82 10.69 184 344391 60734 63083713
Grip strength decreased 38.78 10.69 230 344345 22057 63122390
Therapy cessation 38.72 10.69 66 344509 30391 63114056
Hospitalisation 38.32 10.69 287 344288 84794 63059653
Subdural haematoma 38.08 10.69 15 344560 14313 63130134
Oliguria 37.99 10.69 3 344572 9098 63135349
Blood glucose increased 37.97 10.69 282 344293 83474 63060973
Aphasia 37.97 10.69 76 344499 32924 63111523
Chronic sinusitis 37.79 10.69 154 344421 12689 63131758
Clostridium difficile colitis 37.22 10.69 34 344541 20535 63123912
Blood potassium increased 37.20 10.69 27 344548 18282 63126165
Drug use disorder 37.11 10.69 83 344492 4901 63139546
Stress cardiomyopathy 37.09 10.69 4 344571 9446 63135001
Anuria 37.07 10.69 11 344564 12540 63131907
Rash erythematous 36.93 10.69 373 344202 42137 63102310
Tuberculosis 36.62 10.69 8 344567 11203 63133244
Oxygen saturation decreased 36.57 10.69 306 344269 88279 63056168
Chills 36.54 10.69 416 344159 112962 63031485
Intervertebral discitis 36.44 10.69 64 344511 3164 63141283
Post-traumatic stress disorder 36.39 10.69 85 344490 5166 63139281
Pallor 36.38 10.69 69 344506 30499 63113948
Lethargy 36.38 10.69 168 344407 55839 63088608
White blood cells urine positive 36.30 10.69 84 344491 5074 63139373
Influenza like illness 35.82 10.69 214 344361 66610 63077837
X-ray abnormal 35.70 10.69 111 344464 7999 63136448
Blood pressure decreased 35.50 10.69 207 344368 64815 63079632
Gait disturbance 35.48 10.69 741 343834 182437 62962010
Red blood cells urine positive 35.32 10.69 62 344513 3064 63141383
Peripheral venous disease 35.28 10.69 172 344403 15305 63129142
Restrictive pulmonary disease 35.15 10.69 46 344529 1749 63142698
Respiratory distress 35.08 10.69 83 344492 33868 63110579
Influenza 35.00 10.69 399 344176 108323 63036124
Arrhythmia 34.99 10.69 99 344476 38041 63106406
Toxic epidermal necrolysis 34.94 10.69 52 344523 25282 63119165
Tooth disorder 34.90 10.69 62 344513 28095 63116352
Angina pectoris 34.84 10.69 69 344506 30009 63114438
Intestinal obstruction 34.84 10.69 72 344503 30827 63113620
Balance disorder 34.67 10.69 292 344283 84130 63060317
Vision blurred 34.66 10.69 325 344250 91599 63052848
Cardiotoxicity 34.62 10.69 3 344572 8435 63136012
Granuloma skin 34.62 10.69 3 344572 8434 63136013
Infective pulmonary exacerbation of cystic fibrosis 34.57 10.69 116 344459 8701 63135746
Dyspnoea exertional 34.53 10.69 189 344386 60113 63084334
Hypertensive crisis 34.52 10.69 20 344555 15266 63129181
Spinal fracture 34.52 10.69 29 344546 18242 63126205
Auditory neuropathy spectrum disorder 34.47 10.69 11 344564 22 63144425
Status epilepticus 34.30 10.69 20 344555 15213 63129234
Oral allergy syndrome 34.24 10.69 13 344562 52 63144395
Blepharospasm 34.10 10.69 90 344485 5906 63138541
Neutrophil percentage increased 34.07 10.69 59 344516 2884 63141563
Drug eruption 33.95 10.69 65 344510 28629 63115818
Diverticulitis 33.90 10.69 106 344469 39451 63104996
Blood potassium decreased 33.67 10.69 116 344459 41910 63102537
Myelodysplastic syndrome 33.66 10.69 25 344550 16729 63127718
Ejection fraction decreased 33.65 10.69 43 344532 22289 63122158
Tubulointerstitial nephritis 33.58 10.69 35 344540 19868 63124579
Chronic obstructive pulmonary disease 33.46 10.69 201 344374 62485 63081962
Temperature intolerance 33.45 10.69 116 344459 8848 63135599
Dyskinesia 33.26 10.69 78 344497 31924 63112523
Spinal compression fracture 33.24 10.69 18 344557 14265 63130182
Chronic spontaneous urticaria 33.15 10.69 36 344539 1121 63143326
Enthesopathy 32.92 10.69 4 344571 8610 63135837
Left ventricular dysfunction 32.78 10.69 12 344563 11976 63132471
Product use in unapproved indication 32.63 10.69 1234 343341 177846 62966601
Pulmonary toxicity 32.44 10.69 6 344569 9449 63134998
Muscle rigidity 32.32 10.69 11 344564 11489 63132958
Ileus 32.22 10.69 20 344555 14705 63129742
Hypervolaemia 32.21 10.69 66 344509 28347 63116100
Victim of chemical submission 31.85 10.69 25 344550 507 63143940
Polyneuropathy 31.67 10.69 20 344555 14569 63129878
Rib fracture 31.54 10.69 46 344529 22551 63121896
Blood alkaline phosphatase increased 31.53 10.69 123 344452 42844 63101603
Myoclonus 31.46 10.69 24 344551 15844 63128603
Neonatal hypoacusis 31.34 10.69 10 344565 20 63144427
Obesity 31.11 10.69 273 344302 29679 63114768
Haemorrhage intracranial 31.10 10.69 17 344558 13402 63131045
Injection site pain 31.09 10.69 506 344069 129294 63015153
Blood pressure systolic abnormal 30.96 10.69 17 344558 13369 63131078
Akathisia 30.96 10.69 6 344569 9140 63135307
Skin laceration 30.94 10.69 47 344528 22661 63121786
Hepatic cytolysis 30.94 10.69 23 344552 15384 63129063
Musculoskeletal disorder 30.85 10.69 40 344535 20604 63123843
Tachypnoea 30.84 10.69 29 344546 17273 63127174
Heart rate decreased 30.59 10.69 135 344440 45425 63099022
Urinary retention 30.58 10.69 75 344500 30226 63114221
Pneumocystis jirovecii pneumonia 30.56 10.69 28 344547 16886 63127561
Diabetic ketoacidosis 30.37 10.69 40 344535 20465 63123982
Klebsiella infection 30.34 10.69 5 344570 8561 63135886
Perfume sensitivity 30.26 10.69 29 344546 776 63143671
Musculoskeletal pain 29.96 10.69 338 344237 91939 63052508
Dizziness 29.91 10.69 1971 342604 427954 62716493
Full blood count decreased 29.88 10.69 60 344515 25964 63118483
Inappropriate antidiuretic hormone secretion 29.88 10.69 24 344551 15438 63129009
Escherichia infection 29.79 10.69 16 344559 12738 63131709
Device expulsion 29.63 10.69 94 344481 34828 63109619
Iron deficiency anaemia 29.53 10.69 39 344536 19930 63124517
Intestinal perforation 29.45 10.69 14 344561 11949 63132498
Drug withdrawal syndrome 29.30 10.69 65 344510 27129 63117318
Abdominal pain upper 29.13 10.69 1385 343190 205059 62939388
Bone density decreased 29.10 10.69 22 344553 14590 63129857
Hemiparesis 29.10 10.69 51 344524 23231 63121216
Febrile bone marrow aplasia 29.01 10.69 3 344572 7322 63137125
Unevaluable event 28.91 10.69 162 344413 51224 63093223
Immunisation 28.86 10.69 34 344541 1159 63143288
No adverse event 28.83 10.69 121 344454 41284 63103163
Clostridium difficile infection 28.70 10.69 76 344499 29846 63114601
Cardiogenic shock 28.64 10.69 33 344542 17899 63126548
Haematocrit decreased 28.62 10.69 113 344462 39227 63105220
Abdominal distension 28.61 10.69 316 344259 86299 63058148
Mouth ulceration 28.54 10.69 88 344487 32896 63111551
Hepatitis 28.50 10.69 115 344460 39673 63104774
Tenosynovitis 28.47 10.69 20 344555 13775 63130672
Hyper IgE syndrome 28.47 10.69 23 344552 487 63143960
Seronegative arthritis 28.44 10.69 65 344510 3894 63140553
Hepatic steatosis 28.42 10.69 72 344503 28697 63115750
Neuroleptic malignant syndrome 28.34 10.69 15 344560 12041 63132406
Burning sensation 28.23 10.69 176 344399 54231 63090216
Low birth weight baby 28.02 10.69 3 344572 7126 63137321
Inappropriate schedule of product administration 27.72 10.69 397 344178 103568 63040879
Ischaemic stroke 27.66 10.69 34 344541 17923 63126524
Lymphadenopathy 27.64 10.69 111 344464 38347 63106100
Dialysis 27.58 10.69 11 344564 10416 63134031
Surgery 27.52 10.69 101 344474 35811 63108636
Gastroenteritis 27.48 10.69 65 344510 26525 63117922
Nervous system disorder 27.39 10.69 37 344538 18729 63125718
Premature labour 27.33 10.69 17 344558 12487 63131960
Hallucination, auditory 27.26 10.69 18 344557 12806 63131641
Haemorrhoids 27.25 10.69 49 344526 22101 63122346
Device difficult to use 27.15 10.69 18 344557 12778 63131669
Metastases to lung 26.96 10.69 18 344557 12732 63131715
Red blood cell sedimentation rate abnormal 26.90 10.69 41 344534 19741 63124706
Coronary artery disease 26.87 10.69 88 344487 32289 63112158
Malnutrition 26.84 10.69 26 344549 15272 63129175
Head deformity 26.78 10.69 13 344562 105 63144342
Hepatocellular injury 26.68 10.69 69 344506 27312 63117135
Tricuspid valve incompetence 26.66 10.69 24 344551 14597 63129850
Renal injury 26.58 10.69 9 344566 9430 63135017
Eczema 26.47 10.69 280 344295 32011 63112436
Acidosis 26.37 10.69 14 344561 11219 63133228
Mitral valve incompetence 26.27 10.69 41 344534 19553 63124894
Urine analysis abnormal 26.23 10.69 73 344502 4943 63139504
Bone pain 26.21 10.69 181 344394 54460 63089987
Prescribed underdose 26.03 10.69 261 344314 29428 63115019
Drug ineffective for unapproved indication 25.97 10.69 96 344479 33967 63110480
Diffuse large B-cell lymphoma 25.94 10.69 3 344572 6709 63137738
C-reactive protein increased 25.83 10.69 360 344215 94347 63050100
Lip swelling 25.76 10.69 270 344305 30793 63113654
Mastocytosis 25.69 10.69 23 344552 563 63143884
Sopor 25.54 10.69 51 344524 22113 63122334
Schizophrenia 25.51 10.69 11 344564 9941 63134506
Skin plaque 25.47 10.69 101 344474 8219 63136228
Scratch 25.41 10.69 86 344489 6479 63137968
Breast cancer metastatic 25.37 10.69 17 344558 12001 63132446
Hallucination, visual 25.29 10.69 41 344534 19257 63125190
Cardiac failure acute 25.26 10.69 10 344565 9513 63134934
Drug level decreased 25.17 10.69 6 344569 7913 63136534
Arthritis 25.14 10.69 460 344115 115461 63028986
Oral pain 25.10 10.69 75 344500 28319 63116128
Cytopenia 25.05 10.69 16 344559 11585 63132862
Enteritis 24.95 10.69 7 344568 8279 63136168
Urticaria thermal 24.93 10.69 20 344555 419 63144028
Post cholecystectomy syndrome 24.93 10.69 20 344555 419 63144028
Treatment noncompliance 24.81 10.69 111 344464 37214 63107233
Coagulopathy 24.78 10.69 46 344529 20498 63123949
Drug reaction with eosinophilia and systemic symptoms 24.74 10.69 97 344478 33739 63110708
Deafness 24.63 10.69 37 344538 17920 63126527
Atelectasis 24.27 10.69 50 344525 21433 63123014
Femoral neck fracture 24.22 10.69 8 344567 8515 63135932
Colitis ischaemic 24.19 10.69 14 344561 10694 63133753
Encephalitis 24.10 10.69 9 344566 8871 63135576
Chest pain 24.08 10.69 943 343632 215016 62929431
Anosmia 24.08 10.69 87 344488 6773 63137674
Oral pruritus 24.04 10.69 44 344531 2247 63142200
Diabetes mellitus inadequate control 23.98 10.69 28 344547 15098 63129349
Right ventricular failure 23.98 10.69 35 344540 17153 63127294
Crepitations 23.83 10.69 7 344568 8033 63136414
Headache 23.81 10.69 3847 340728 629394 62515053
Failure to thrive 23.79 10.69 5 344570 7193 63137254
Eosinophilic colitis 23.76 10.69 14 344561 173 63144274
Antinuclear antibody positive 23.64 10.69 7 344568 7992 63136455
Red blood cell count decreased 23.49 10.69 127 344448 40518 63103929
Lymphoma 23.45 10.69 19 344556 12168 63132279
Device malfunction 23.34 10.69 38 344537 17819 63126628
Torsade de pointes 23.07 10.69 23 344552 13328 63131119
Incorrect dose administered 23.04 10.69 211 344364 59757 63084690
Ear infection 22.83 10.69 312 344263 37901 63106546
Haemodialysis 22.76 10.69 10 344565 8937 63135510
Dementia 22.74 10.69 42 344533 18752 63125695
Faeces discoloured 22.72 10.69 41 344534 18468 63125979
Breast cancer female 22.70 10.69 24 344551 13535 63130912
Bronchial neoplasm 22.66 10.69 20 344555 480 63143967
Hypotonia 22.65 10.69 11 344564 9274 63135173
Hydronephrosis 22.62 10.69 15 344560 10647 63133800
Vaginal haemorrhage 22.61 10.69 75 344500 27412 63117035
Eating disorder 22.56 10.69 43 344532 18973 63125474
Mast cell activation syndrome 22.47 10.69 25 344550 800 63143647
Bronchiectasis 22.39 10.69 33 344542 16109 63128338
Paraesthesia oral 22.38 10.69 180 344395 19076 63125371
Walking aid user 22.25 10.69 116 344459 10601 63133846
Intentional self-injury 21.89 10.69 69 344506 25618 63118829
Disorientation 21.85 10.69 125 344450 39327 63105120
Cholelithiasis 21.82 10.69 144 344431 43781 63100666
Rash maculo-papular 21.72 10.69 94 344481 31802 63112645
Hypothermia 21.68 10.69 25 344550 13556 63130891
Dysphagia 21.65 10.69 344 344231 88241 63056206
Staphylococcal infection 21.64 10.69 133 344442 41123 63103324
Circulatory collapse 21.59 10.69 55 344520 21883 63122564
Caesarean section 21.57 10.69 37 344538 16995 63127452
Joint range of motion decreased 21.56 10.69 270 344305 32158 63112289
Migraine 21.49 10.69 723 343852 102623 63041824
Drug hypersensitivity 21.46 10.69 1425 343150 309262 62835185
Mobility decreased 21.37 10.69 832 343743 120327 63024120
Multiple fractures 21.35 10.69 10 344565 8608 63135839
Breast cancer stage III 21.27 10.69 112 344463 10274 63134173
Nocturnal fear 21.20 10.69 6 344569 6 63144441
Hepatic encephalopathy 21.20 10.69 18 344557 11264 63133183
Humerus fracture 21.10 10.69 11 344564 8905 63135542
Lichen sclerosus 21.06 10.69 28 344547 1081 63143366
Ventricular fibrillation 21.02 10.69 20 344555 11847 63132600
Blood urea increased 21.01 10.69 73 344502 26306 63118141
Pregnancy on contraceptive 20.98 10.69 29 344546 1163 63143284
Flatulence 20.85 10.69 107 344468 34595 63109852
Urinary incontinence 20.81 10.69 96 344479 31918 63112529
Seasonal allergy 20.75 10.69 189 344386 20761 63123686
Dysarthria 20.72 10.69 141 344434 42570 63101877
Heart rate irregular 20.71 10.69 58 344517 22363 63122084
Brain oedema 20.71 10.69 28 344547 14167 63130280
Nephrolithiasis 20.67 10.69 138 344437 41846 63102601
Product administration error 20.65 10.69 58 344517 22339 63122108
Immune reconstitution inflammatory syndrome 20.58 10.69 4 344571 6080 63138367
Systemic inflammatory response syndrome 20.55 10.69 3 344572 5618 63138829
Cestode infection 20.53 10.69 15 344560 272 63144175
Abdominal pain lower 20.49 10.69 71 344504 25607 63118840
Candida infection 20.27 10.69 82 344493 28269 63116178
Fistula 20.25 10.69 16 344559 10377 63134070
Diarrhoea haemorrhagic 20.18 10.69 12 344563 9030 63135417
Cystic fibrosis pancreatic 20.12 10.69 9 344566 59 63144388
Spinal pain 20.11 10.69 25 344550 13114 63131333
Gastric haemorrhage 20.04 10.69 5 344570 6393 63138054
Poisoning 20.01 10.69 27 344548 13673 63130774
Myocarditis 19.99 10.69 16 344559 10309 63134138
Laryngitis 19.94 10.69 159 344416 16808 63127639
Hemiplegia 19.93 10.69 13 344562 9310 63135137
Bacterial infection 19.88 10.69 48 344527 19451 63124996
Electrocardiogram QRS complex prolonged 19.88 10.69 4 344571 5934 63138513
Gastric disorder 19.85 10.69 120 344455 37249 63107198
C-reactive protein 19.83 10.69 65 344510 4817 63139630
Mental disorder 19.79 10.69 73 344502 25846 63118601
Stillbirth 19.78 10.69 6 344569 6744 63137703
Head injury 19.74 10.69 79 344496 27317 63117130
Hypoalbuminaemia 19.65 10.69 21 344554 11784 63132663
Lung infiltration 19.64 10.69 30 344545 14433 63130014
Prothrombin time prolonged 19.56 10.69 14 344561 9550 63134897
Injection site haemorrhage 19.55 10.69 67 344508 24247 63120200
Splenomegaly 19.53 10.69 19 344556 11138 63133309
Mechanical urticaria 19.53 10.69 18 344557 458 63143989
Cough 19.50 10.69 1347 343228 291396 62853051
Haemodynamic instability 19.40 10.69 13 344562 9177 63135270
Ankylosing spondylitis 19.33 10.69 17 344558 10457 63133990
Sudden death 19.23 10.69 17 344558 10432 63134015
Troponin increased 19.20 10.69 16 344559 10105 63134342
Forced expiratory volume decreased 19.16 10.69 65 344510 4903 63139544
Victim of sexual abuse 19.10 10.69 21 344554 663 63143784
Visual acuity reduced 19.04 10.69 58 344517 21768 63122679
Pulmonary mass 19.04 10.69 61 344514 22535 63121912
Nasal turbinate hypertrophy 18.88 10.69 22 344553 741 63143706
Gangrene 18.76 10.69 5 344570 6118 63138329
Sinus tachycardia 18.76 10.69 68 344507 24200 63120247
Rash pustular 18.74 10.69 8 344567 7274 63137173
Pyelonephritis 18.74 10.69 43 344532 17735 63126712
Unintentional medical device removal 18.73 10.69 5 344570 6110 63138337
Atrioventricular block first degree 18.71 10.69 8 344567 7265 63137182
Oesophagitis 18.64 10.69 33 344542 14975 63129472
Impaired work ability 18.64 10.69 42 344533 17433 63127014
Atrial tachycardia 18.63 10.69 58 344517 4182 63140265
Granulocytopenia 18.62 10.69 4 344571 5668 63138779
Hypernatraemia 18.59 10.69 9 344566 7600 63136847
Second primary malignancy 18.54 10.69 10 344565 7943 63136504
Blood immunoglobulin A increased 18.54 10.69 22 344553 756 63143691
Metastasis 18.48 10.69 3 344572 5194 63139253
Cyst 18.43 10.69 30 344545 14069 63130378
Osteopenia 18.41 10.69 51 344524 19734 63124713
Schizophreniform disorder 18.40 10.69 9 344566 74 63144373
Tension headache 18.40 10.69 66 344509 5120 63139327
Ataxia 18.35 10.69 34 344541 15161 63129286
Pregnancy 18.18 10.69 291 344284 36545 63107902
Polyuria 18.14 10.69 12 344563 8530 63135917
Ovarian cancer 18.09 10.69 5 344570 5971 63138476
Throat irritation 18.05 10.69 296 344279 37351 63107096
Parkinsonism 18.02 10.69 18 344557 10421 63134026
Intestinal ischaemia 17.99 10.69 9 344566 7459 63136988
Bronchial haemorrhage 17.98 10.69 19 344556 573 63143874
Peripheral sensory neuropathy 17.92 10.69 9 344566 7442 63137005
Hypomania 17.89 10.69 6 344569 6324 63138123
Apathy 17.82 10.69 13 344562 8781 63135666
Therapy partial responder 17.69 10.69 19 344556 10639 63133808
Muscle atrophy 17.67 10.69 8 344567 7025 63137422
Malaise 17.65 10.69 1982 342593 413972 62730475
Glomerular filtration rate increased 17.56 10.69 23 344552 875 63143572
Epstein-Barr virus infection 17.52 10.69 11 344564 8039 63136408
Renal cyst 17.51 10.69 18 344557 10284 63134163
Toothache 17.49 10.69 50 344525 19149 63125298
Condition aggravated 17.48 10.69 2464 342111 399753 62744694
Intervertebral disc degeneration 17.45 10.69 37 344538 15695 63128752
Injection site erythema 17.43 10.69 332 344243 82842 63061605
Glaucoma 17.39 10.69 49 344526 18856 63125591
Hyperpathia 17.36 10.69 6 344569 17 63144430
Tumour lysis syndrome 17.31 10.69 14 344561 8976 63135471
Allergy test positive 17.26 10.69 19 344556 601 63143846
Neurological symptom 17.20 10.69 5 344570 5778 63138669
Pancreatic carcinoma 17.19 10.69 10 344565 7618 63136829
Gastritis 17.19 10.69 125 344450 37178 63107269
Device use error 17.10 10.69 5 344570 5756 63138691
Breast cancer stage I 17.06 10.69 8 344567 6881 63137566
Escherichia urinary tract infection 17.04 10.69 24 344551 11938 63132509
Dry mouth 17.02 10.69 548 344027 77315 63067132
Aphthous ulcer 16.99 10.69 31 344544 13907 63130540
Loss of personal independence in daily activities 16.98 10.69 400 344175 96890 63047557
Motor dysfunction 16.97 10.69 20 344555 10741 63133706
Malignant melanoma 16.97 10.69 22 344553 11334 63133113
Metabolic disorder 16.97 10.69 7 344568 6496 63137951
Cachexia 16.94 10.69 5 344570 5721 63138726
Aspartate aminotransferase 16.92 10.69 16 344559 421 63144026
Full blood count abnormal 16.77 10.69 102 344473 31615 63112832
Atrial flutter 16.70 10.69 17 344558 9755 63134692
Abnormal behaviour 16.59 10.69 60 344515 21366 63123081
Cardiovascular disorder 16.53 10.69 24 344551 11788 63132659
Facial pain 16.49 10.69 106 344469 10455 63133992
Pulmonary arterial hypertension 16.33 10.69 65 344510 22512 63121935
Pollakiuria 16.30 10.69 87 344488 27850 63116597
Amylase increased 16.29 10.69 7 344568 6338 63138109
Arterial occlusive disease 16.23 10.69 6 344569 5952 63138495
Myocardial ischaemia 16.22 10.69 28 344547 12831 63131616
Histamine level increased 16.21 10.69 6 344569 22 63144425
Gastric cancer 16.20 10.69 3 344572 4720 63139727
Cholangitis 16.19 10.69 5 344570 5556 63138891
Blood albumin decreased 16.15 10.69 35 344540 14731 63129716
Uveitis 16.14 10.69 27 344548 12526 63131921
Food intolerance 16.04 10.69 47 344528 3278 63141169
Sinus node dysfunction 16.02 10.69 3 344572 4682 63139765
Urine output decreased 16.01 10.69 23 344552 11347 63133100
Colon cancer 15.97 10.69 18 344557 9860 63134587
Bacterial test positive 15.90 10.69 64 344511 5243 63139204
Hyperthyroidism 15.86 10.69 35 344540 14638 63129809
Necrosis 15.86 10.69 5 344570 5482 63138965
Acute coronary syndrome 15.78 10.69 19 344556 10107 63134340
Faecaloma 15.76 10.69 12 344563 7929 63136518
Toxic encephalopathy 15.74 10.69 8 344567 6571 63137876
Laryngeal stenosis 15.73 10.69 24 344551 1054 63143393
Hyperlipidaemia 15.69 10.69 54 344521 19517 63124930
Device issue 15.64 10.69 71 344504 23710 63120737
Blood sodium decreased 15.60 10.69 73 344502 24179 63120268
Speech disorder 15.58 10.69 143 344432 40486 63103961
Congestive cardiomyopathy 15.58 10.69 7 344568 6175 63138272
Dysuria 15.57 10.69 113 344462 33625 63110822
Hyperthermia 15.56 10.69 16 344559 9140 63135307
Lower gastrointestinal haemorrhage 15.56 10.69 12 344563 7878 63136569
Cardiac murmur 15.50 10.69 35 344540 14517 63129930
Pre-eclampsia 15.48 10.69 16 344559 9117 63135330
Paraesthesia 15.46 10.69 695 343880 156271 62988176
Enterocolitis 15.43 10.69 12 344563 7846 63136601
Glomerular filtration rate decreased 15.42 10.69 31 344544 13410 63131037
Monocyte count abnormal 15.41 10.69 11 344564 192 63144255
Back pain 15.41 10.69 1229 343346 262916 62881531
Myopathy 15.41 10.69 23 344552 11168 63133279
Pulmonary congestion 15.40 10.69 46 344529 17372 63127075
Ulcer 15.40 10.69 81 344494 26026 63118421
Large intestine perforation 15.37 10.69 14 344561 8468 63135979
Metastases to lymph nodes 15.35 10.69 13 344562 8145 63136302
Device related infection 15.29 10.69 70 344505 23322 63121125
Affect lability 15.27 10.69 23 344552 11128 63133319
Carotid artery occlusion 15.20 10.69 58 344517 4636 63139811
Lymphoedema 15.17 10.69 25 344550 11667 63132780
Vertigo 15.16 10.69 231 344344 59656 63084791
Aspergillus infection 15.10 10.69 13 344562 8080 63136367
Tumour marker increased 15.09 10.69 4 344571 4911 63139536
Duodenal ulcer 15.04 10.69 12 344563 7744 63136703
Venous thrombosis 15.03 10.69 4 344571 4898 63139549
Spinal stenosis 15.01 10.69 37 344538 14888 63129559
Red cell distribution width decreased 14.94 10.69 34 344541 2031 63142416
White blood cell count increased 14.93 10.69 180 344395 48381 63096066
Blood pressure diastolic decreased 14.81 10.69 68 344507 22638 63121809
Hypoacusis 14.77 10.69 74 344501 24077 63120370
Kidney infection 14.76 10.69 70 344505 23106 63121341
Leukoencephalopathy 14.72 10.69 3 344572 4410 63140037
Nail operation 14.69 10.69 21 344554 869 63143578
Respiratory tract infection 14.65 10.69 149 344426 41334 63103113
Dysstasia 14.64 10.69 62 344513 21104 63123343
Post procedural haemorrhage 14.61 10.69 13 344562 7951 63136496
Atopy 14.58 10.69 12 344563 261 63144186
Lichen nitidus 14.53 10.69 8 344567 86 63144361
Atrioventricular block complete 14.50 10.69 14 344561 8237 63136210
Pneumonia bacterial 14.50 10.69 18 344557 9447 63135000
Delusion 14.41 10.69 27 344548 11990 63132457
Pneumothorax 14.34 10.69 43 344532 16218 63128229
Mental impairment 14.30 10.69 35 344540 14116 63130331
Blood pressure abnormal 14.27 10.69 39 344536 15159 63129288
Mixed liver injury 14.26 10.69 4 344571 4731 63139716
Cold urticaria 14.25 10.69 9 344566 127 63144320
Urinary casts 14.25 10.69 19 344556 736 63143711
Eye disorder 14.17 10.69 69 344506 22616 63121831
Skin discolouration 14.14 10.69 134 344441 37694 63106753
Decubitus ulcer 14.12 10.69 22 344553 10498 63133949
Pulmonary haemorrhage 14.06 10.69 11 344564 7170 63137277
Bedridden 14.00 10.69 24 344551 11027 63133420
Exposure via body fluid 13.99 10.69 17 344558 599 63143848
Lipase increased 13.97 10.69 20 344555 9880 63134567
Insomnia 13.95 10.69 1353 343222 213899 62930548
Hyperbilirubinaemia 13.94 10.69 25 344550 11289 63133158
Prevertebral soft tissue swelling of cervical space 13.85 10.69 6 344569 36 63144411
Musculoskeletal chest pain 13.83 10.69 63 344512 21020 63123427
Generalised oedema 13.83 10.69 42 344533 15776 63128671
Normochromic normocytic anaemia 13.81 10.69 4 344571 4632 63139815
Aortic stenosis 13.77 10.69 5 344570 5015 63139432
Body temperature decreased 13.76 10.69 60 344515 20259 63124188
Demyelination 13.75 10.69 74 344501 6846 63137601
Anaphylactoid reaction 13.74 10.69 48 344527 3675 63140772
Haemolysis 13.72 10.69 10 344565 6758 63137689
Lip pruritus 13.70 10.69 21 344554 926 63143521
Foot fracture 13.66 10.69 75 344500 23839 63120608
Pain of skin 13.66 10.69 109 344466 11525 63132922
Cryopyrin associated periodic syndrome 13.59 10.69 13 344562 347 63144100
Arteriosclerosis 13.56 10.69 21 344554 10045 63134402
Electrocardiogram abnormal 13.50 10.69 18 344557 9161 63135286
Muscular weakness 13.47 10.69 535 344040 121818 63022629
Oligohydramnios 13.45 10.69 9 344566 6357 63138090
Limb injury 13.43 10.69 82 344493 25395 63119052
Ileus paralytic 13.42 10.69 4 344571 4547 63139900
Eye swelling 13.36 10.69 193 344382 23725 63120722
Flank pain 13.35 10.69 45 344530 16365 63128082
Nephropathy 13.34 10.69 9 344566 6332 63138115
Pathological fracture 13.32 10.69 17 344558 8817 63135630
Dysgeusia 13.29 10.69 176 344399 46534 63097913
Granulocyte count increased 13.28 10.69 20 344555 868 63143579
Tendonitis 13.24 10.69 58 344517 19557 63124890
Embolism 13.23 10.69 14 344561 7892 63136555
Thirst 13.21 10.69 36 344539 14005 63130442
Alanine aminotransferase abnormal 13.21 10.69 4 344571 4500 63139947
Suicidal ideation 13.13 10.69 249 344326 62172 63082275
Drug level below therapeutic 13.09 10.69 5 344570 4861 63139586
Hypercholesterolaemia 13.07 10.69 175 344400 21159 63123288
Post procedural infection 13.05 10.69 19 344556 9323 63135124
Enterococcal infection 13.02 10.69 14 344561 7834 63136613
Hypertriglyceridaemia 13.02 10.69 9 344566 6250 63138197
Suspected suicide 12.94 10.69 10 344565 6558 63137889
Anal fissure 12.93 10.69 4 344571 4439 63140008
Magnesium deficiency 12.90 10.69 16 344559 576 63143871
Movement disorder 12.89 10.69 67 344508 21594 63122853
Sinus disorder 12.89 10.69 196 344379 24357 63120090
Exostosis 12.86 10.69 151 344424 17711 63126736
Nystagmus 12.86 10.69 9 344566 6211 63138236
Scleritis 12.86 10.69 4 344571 4424 63140023
Upper limb fracture 12.85 10.69 56 344519 18912 63125535
Soft tissue disorder 12.83 10.69 4 344571 4418 63140029
Myositis 12.80 10.69 19 344556 9247 63135200
Hypovolaemia 12.78 10.69 24 344551 10649 63133798
Neutropenic sepsis 12.75 10.69 46 344529 16392 63128055
Spinal osteoarthritis 12.75 10.69 45 344530 16141 63128306
Rash pruritic 12.74 10.69 238 344337 59561 63084886
Cyanosis 12.73 10.69 48 344527 16887 63127560
Postoperative wound infection 12.71 10.69 25 344550 10900 63133547
Haemophagocytic lymphohistiocytosis 12.64 10.69 24 344551 10603 63133844
Cells in urine 12.61 10.69 10 344565 206 63144241
Pleuritic pain 12.58 10.69 15 344560 8014 63136433
Bronchial disorder 12.57 10.69 24 344551 1266 63143181
Uterine cancer 12.51 10.69 5 344570 4728 63139719
Haemorrhagic stroke 12.49 10.69 8 344567 5784 63138663
Tongue pruritus 12.47 10.69 15 344560 523 63143924
Post procedural complication 12.45 10.69 49 344526 17025 63127422
Supraventricular tachycardia 12.40 10.69 38 344537 14233 63130214
Liver function test increased 12.36 10.69 116 344459 32695 63111752
Hepatomegaly 12.33 10.69 29 344546 11860 63132587
Blood magnesium decreased 12.30 10.69 34 344541 13164 63131283
Respirovirus test positive 12.29 10.69 5 344570 25 63144422
Lupus-like syndrome 12.24 10.69 132 344443 15163 63129284
Chemical submission 12.23 10.69 11 344564 271 63144176
Blood iron abnormal 12.19 10.69 3 344572 3873 63140574
Monocyte count increased 12.19 10.69 76 344499 7417 63137030
Stupor 12.17 10.69 4 344571 4271 63140176
Hyperuricaemia 12.16 10.69 7 344568 5363 63139084
Erysipelas 12.14 10.69 15 344560 7890 63136557
Epidermolysis bullosa 12.13 10.69 8 344567 122 63144325
Escherichia sepsis 12.11 10.69 6 344569 5001 63139446
Hypertonia 12.09 10.69 5 344570 4632 63139815
Personality change 12.06 10.69 12 344563 6961 63137486
Wound infection 12.06 10.69 173 344402 21237 63123210
Endometrial ablation 12.05 10.69 20 344555 944 63143503
Sickle cell anaemia with crisis 12.00 10.69 9 344566 5994 63138453
Menstruation delayed 11.99 10.69 28 344547 1701 63142746
Acute pulmonary oedema 11.99 10.69 16 344559 8142 63136305
Middle insomnia 11.99 10.69 113 344462 12530 63131917
Pelvic fracture 11.99 10.69 35 344540 13313 63131134
Vertigo CNS origin 11.97 10.69 5 344570 27 63144420
Foetal growth restriction 11.95 10.69 14 344561 7539 63136908
Cholecystitis 11.94 10.69 43 344532 15334 63129113
Aortic valve incompetence 11.94 10.69 9 344566 5979 63138468
Disease recurrence 11.94 10.69 96 344479 27934 63116513
Haemolytic anaemia 11.92 10.69 23 344552 10102 63134345
Emphysema 11.90 10.69 26 344549 10912 63133535
Supraventricular extrasystoles 11.88 10.69 5 344570 4584 63139863
Dystonia 11.86 10.69 37 344538 13782 63130665
Muscle spasms 11.84 10.69 710 343865 155440 62989007
Urine amphetamine positive 11.81 10.69 6 344569 54 63144393
Subarachnoid haemorrhage 11.77 10.69 124 344451 14159 63130288
Activated partial thromboplastin time prolonged 11.77 10.69 12 344563 6881 63137566
Nephrogenic systemic fibrosis 11.74 10.69 5 344570 4551 63139896
Tenderness 11.73 10.69 73 344502 22505 63121942
Blood creatine increased 11.72 10.69 8 344567 5593 63138854
Tongue disorder 11.63 10.69 25 344550 10555 63133892
Nephrotic syndrome 11.62 10.69 8 344567 5568 63138879
Thymus disorder 11.61 10.69 11 344564 290 63144157
Renal cancer 11.56 10.69 8 344567 5554 63138893
Obstructive airways disorder 11.55 10.69 167 344408 20532 63123915
Bronchitis 11.54 10.69 557 344018 124378 63020069
Injection site bruising 11.53 10.69 159 344416 41751 63102696
Ovarian cyst 11.47 10.69 46 344529 15899 63128548
Presyncope 11.45 10.69 96 344479 27689 63116758
Ehlers-Danlos syndrome 11.45 10.69 9 344566 183 63144264
Hepatic cancer 11.44 10.69 5 344570 4482 63139965
Aplasia pure red cell 11.44 10.69 5 344570 4482 63139965
Autophobia 11.41 10.69 4 344571 12 63144435
Eye pain 11.38 10.69 123 344452 33731 63110716
Feeling abnormal 11.38 10.69 674 343901 147718 62996729
Partial seizures 11.37 10.69 9 344566 5833 63138614
Nerve injury 11.36 10.69 23 344552 9923 63134524
Blood lactic acid increased 11.36 10.69 13 344562 7073 63137374
Cardiomegaly 11.34 10.69 53 344522 17561 63126886
Small intestinal obstruction 11.32 10.69 56 344519 18281 63126166
Spinal cord paralysis 11.28 10.69 5 344570 32 63144415
Neck pain 11.27 10.69 288 344287 69030 63075417
Atrioventricular block 11.24 10.69 15 344560 7632 63136815
Wrist fracture 11.23 10.69 37 344538 13550 63130897
Neoplasm 11.22 10.69 14 344561 7331 63137116
Transient ischaemic attack 11.21 10.69 141 344434 37612 63106835
Tardive dyskinesia 11.20 10.69 18 344557 8484 63135963
Joint effusion 11.18 10.69 51 344524 17009 63127438
Proctalgia 11.17 10.69 10 344565 6100 63138347
Skin cancer 11.17 10.69 29 344546 11466 63132981
Genital haemorrhage 11.17 10.69 14 344561 7318 63137129
Cerebral ischaemia 11.16 10.69 12 344563 6716 63137731
Tibia fracture 11.14 10.69 7 344568 5113 63139334
Poisoning deliberate 11.14 10.69 28 344547 11190 63133257
Pulmonary fibrosis 11.13 10.69 289 344286 39520 63104927
Coronary artery occlusion 11.12 10.69 17 344558 8174 63136273
Immunosuppressant drug level increased 11.09 10.69 3 344572 3635 63140812
Diverticulum 11.09 10.69 31 344544 11960 63132487
Hyperpyrexia 11.07 10.69 3 344572 3629 63140818
Poor venous access 11.06 10.69 42 344533 14743 63129704
Urine odour abnormal 11.05 10.69 11 344564 6378 63138069
Clostridial infection 11.03 10.69 5 344570 4387 63140060
Catheter site pain 10.97 10.69 6 344569 4729 63139718
Ventricular septal defect 10.97 10.69 5 344570 4373 63140074
Ketoacidosis 10.97 10.69 5 344570 4373 63140074
Body height decreased 10.93 10.69 24 344551 10054 63134393
Rales 10.89 10.69 34 344541 12663 63131784
Skin toxicity 10.88 10.69 6 344569 4708 63139739
Adenovirus infection 10.78 10.69 3 344572 3568 63140879
Bacterial sepsis 10.76 10.69 4 344571 3954 63140493
Deficiency of bile secretion 10.74 10.69 4 344571 15 63144432

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 317.85 10.52 401 66881 42255 34847394
Pruritus 296.54 10.52 764 66518 141217 34748432
Urticaria 270.77 10.52 454 66828 61923 34827726
Dermatitis atopic 238.48 10.52 141 67141 5206 34884443
Sleep terror 231.18 10.52 105 67177 2213 34887436
Pruritus genital 141.85 10.52 74 67208 2130 34887519
Cardiospasm 133.75 10.52 64 67218 1524 34888125
Eye pruritus 132.12 10.52 112 67170 7377 34882272
Lip swelling 130.65 10.52 158 67124 15922 34873727
Dry skin 122.86 10.52 218 67064 31069 34858580
Facial pain 120.60 10.52 80 67202 3624 34886025
Palmoplantar keratoderma 118.38 10.52 63 67219 1890 34887759
Death 112.51 10.52 392 66890 397657 34491992
Migraine 105.00 10.52 148 67134 17330 34872319
Tension headache 104.63 10.52 68 67214 2974 34886675
Anosmia 100.80 10.52 74 67208 3950 34885699
Rash 97.25 10.52 747 66535 222005 34667644
Sinusitis 94.71 10.52 231 67051 41171 34848478
Atrial tachycardia 93.50 10.52 68 67214 3577 34886072
Immunisation 89.47 10.52 43 67239 1034 34888615
Pain of skin 89.05 10.52 82 67200 6027 34883622
Angioedema 85.99 10.52 209 67073 37165 34852484
Carotid artery occlusion 85.30 10.52 65 67217 3672 34885977
Eczema 82.29 10.52 136 67146 18300 34871349
Anaemia 76.14 10.52 215 67067 233120 34656529
Disturbance in attention 75.17 10.52 159 67123 25786 34863863
Infective pulmonary exacerbation of cystic fibrosis 74.34 10.52 78 67204 6723 34882926
Forced expiratory volume decreased 71.55 10.52 55 67227 3148 34886501
Headache 70.49 10.52 641 66641 199994 34689655
Upper respiratory tract infection 68.84 10.52 178 67104 32881 34856768
Muscle twitching 67.56 10.52 91 67191 10207 34879442
Product dose omission issue 64.67 10.52 423 66859 119288 34770361
Hypersensitivity 63.39 10.52 259 67023 60776 34828873
Illness 63.35 10.52 102 67180 13427 34876222
Wheezing 62.92 10.52 199 67083 41203 34848446
Rash papular 60.20 10.52 86 67196 10192 34879457
Vital capacity decreased 59.79 10.52 24 67258 368 34889281
General physical health deterioration 58.50 10.52 98 67184 128171 34761478
Eye disorder 57.69 10.52 81 67201 9447 34880202
Multiple organ dysfunction syndrome 56.61 10.52 39 67243 76527 34813122
COVID-19 56.08 10.52 296 66986 77254 34812395
Anxiety 51.66 10.52 348 66934 99080 34790569
Renal failure 50.56 10.52 110 67172 130447 34759202
Lower respiratory tract infection 48.92 10.52 153 67129 31484 34858165
Toxicity to various agents 48.23 10.52 210 67072 200152 34689497
Parathyroid gland enlargement 47.81 10.52 16 67266 141 34889508
Malaise 47.70 10.52 557 66725 185268 34704381
Acute kidney injury 46.60 10.52 370 66912 304618 34585031
Upper respiratory fungal infection 46.29 10.52 16 67266 157 34889492
Renal impairment 45.15 10.52 70 67212 94443 34795206
Cough 44.93 10.52 464 66818 149676 34739973
Tinnitus 43.61 10.52 110 67172 20008 34869641
Heart rate increased 42.95 10.52 190 67092 46153 34843496
Palpitations 41.75 10.52 170 67112 39816 34849833
Pericarditis 41.71 10.52 78 67204 11567 34878082
Accident 41.65 10.52 50 67232 4997 34884652
Potassium wasting nephropathy 41.34 10.52 13 67269 92 34889557
Disease progression 41.06 10.52 92 67190 107985 34781664
Swelling face 40.69 10.52 117 67165 22988 34866661
Cardiac failure 40.40 10.52 71 67211 91177 34798472
Nasal congestion 39.87 10.52 116 67166 22941 34866708
Completed suicide 39.42 10.52 81 67201 98087 34791562
Forced expiratory volume 39.01 10.52 13 67269 113 34889536
Influenza 38.97 10.52 194 67088 49472 34840177
Erythema 38.73 10.52 298 66984 88482 34801167
Anaphylactic reaction 38.33 10.52 143 67139 32158 34857491
Throat irritation 38.03 10.52 71 67211 10514 34879135
Amnesia 37.92 10.52 125 67157 26438 34863211
Malignant neoplasm progression 37.65 10.52 70 67212 87976 34801673
Feeling abnormal 37.54 10.52 229 67053 63006 34826643
Chest discomfort 37.27 10.52 205 67077 54325 34835324
Interstitial lung disease 36.59 10.52 43 67239 65239 34824410
Subarachnoid haemorrhage 36.09 10.52 77 67205 12558 34877091
Vasculitis 35.98 10.52 72 67210 11224 34878425
Sepsis 35.69 10.52 182 67100 166379 34723270
Alopecia 35.11 10.52 115 67167 24240 34865409
Fatigue 34.77 10.52 946 66336 369707 34519942
Mydriasis 34.48 10.52 55 67227 7182 34882467
Ascites 34.04 10.52 24 67258 46547 34843102
Insomnia 33.89 10.52 327 66955 103580 34786069
Gastrointestinal haemorrhage 33.86 10.52 75 67207 88402 34801247
Sudden infant death syndrome 33.78 10.52 14 67268 234 34889415
Dry eye 32.88 10.52 63 67219 9512 34880137
Anal inflammation 32.77 10.52 24 67258 1276 34888373
Throat tightness 32.48 10.52 58 67224 8300 34881349
Cardiogenic shock 32.38 10.52 6 67276 26612 34863037
Diplopia 32.32 10.52 88 67194 16755 34872894
Platelet count decreased 31.57 10.52 121 67161 119596 34770053
Drug resistance 31.21 10.52 6 67276 25921 34863728
Fixed eruption 31.17 10.52 26 67256 1674 34887975
Drug ineffective 30.85 10.52 658 66624 456093 34433556
Seasonal allergy 30.80 10.52 50 67232 6625 34883024
Radiation inflammation 30.56 10.52 20 67262 885 34888764
Oral pruritus 30.43 10.52 14 67268 304 34889345
Hyperhidrosis 30.23 10.52 249 67033 75443 34814206
Crystal urine present 30.09 10.52 16 67266 479 34889170
Tendon disorder 29.70 10.52 32 67250 2843 34886806
Drug interaction 29.61 10.52 285 66997 225661 34663988
Pulmonary pain 29.51 10.52 22 67260 1202 34888447
Penis injury 29.42 10.52 13 67269 256 34889393
Penile haemorrhage 28.68 10.52 17 67265 630 34889019
Pancytopenia 28.56 10.52 91 67191 95066 34794583
Blindness 28.46 10.52 78 67204 14908 34874741
Nasal oedema 28.41 10.52 14 67268 356 34889293
Visual impairment 28.19 10.52 140 67142 35662 34853987
Bronchopulmonary aspergillosis allergic 27.69 10.52 19 67263 910 34888739
Rash pruritic 27.69 10.52 114 67168 26827 34862822
Cardiac arrest 27.46 10.52 94 67188 96065 34793584
Ocular hyperaemia 27.35 10.52 65 67217 11387 34878262
Sinus congestion 27.26 10.52 43 67239 5562 34884087
Injection site swelling 27.07 10.52 65 67217 11462 34878187
Prostate cancer 26.97 10.52 22 67260 39627 34850022
Infusion site pain 26.75 10.52 35 67247 3816 34885833
SARS-CoV-2 test negative 26.09 10.52 19 67263 1001 34888648
Bone marrow failure 25.77 10.52 12 67270 29241 34860408
Pulmonary function test decreased 25.35 10.52 39 67243 4936 34884713
Conjunctivitis 25.28 10.52 57 67225 9648 34880001
Aplastic anaemia 25.24 10.52 57 67225 9659 34879990
Ear infection 24.36 10.52 58 67224 10173 34879476
Neurotoxicity 24.33 10.52 3 67279 18007 34871642
Differentiation syndrome 24.33 10.52 21 67261 1417 34888232
Patient elopement 24.31 10.52 7 67275 35 34889614
Flushing 24.27 10.52 125 67157 32295 34857354
Myelosuppression 24.18 10.52 4 67278 19261 34870388
Blood pressure increased 23.85 10.52 267 67015 87835 34801814
Cognitive disorder 23.15 10.52 113 67169 28580 34861069
Thrombocytopenia 23.12 10.52 191 67091 156056 34733593
Pleural effusion 23.08 10.52 80 67202 81466 34808183
Infusion related reaction 23.07 10.52 178 67104 52879 34836770
Hepatic function abnormal 23.00 10.52 31 67251 44332 34845317
Hypotension 22.92 10.52 295 66987 221354 34668295
Sleep disorder 22.91 10.52 121 67161 31567 34858082
Leukopenia 22.66 10.52 55 67227 62801 34826848
International normalised ratio increased 22.64 10.52 35 67247 47292 34842357
Suicidal ideation 22.55 10.52 144 67138 40244 34849405
Disseminated intravascular coagulation 22.46 10.52 7 67275 21809 34867840
Obstructive airways disorder 22.19 10.52 73 67209 15421 34874228
Rhinorrhoea 22.10 10.52 103 67179 25565 34864084
Septic shock 22.04 10.52 68 67214 71766 34817883
Respiratory failure 21.91 10.52 121 67161 108451 34781198
Transient ischaemic attack 21.75 10.52 108 67174 27505 34862144
Cerebral infarction 21.62 10.52 13 67269 27442 34862207
Victim of chemical submission 21.62 10.52 7 67275 55 34889594
Rheumatoid arthritis 21.62 10.52 25 67257 38213 34851436
Congenital genital malformation 21.47 10.52 9 67273 155 34889494
Rash erythematous 21.34 10.52 100 67182 24877 34864772
Rash macular 20.67 10.52 63 67219 12779 34876870
Mood altered 20.51 10.52 50 67232 8902 34880747
Anticholinergic syndrome 20.40 10.52 18 67264 1251 34888398
Mastocytosis 20.36 10.52 6 67276 33 34889616
Hallucination 20.33 10.52 169 67113 51329 34838320
Proctalgia 20.08 10.52 38 67244 5685 34883964
Middle insomnia 20.06 10.52 42 67240 6760 34882889
Tonsillitis 20.04 10.52 24 67258 2392 34887257
Sinus disorder 20.03 10.52 43 67239 7042 34882607
Cerebral dysgenesis 19.90 10.52 5 67277 13 34889636
C-reactive protein increased 19.76 10.52 47 67235 54051 34835598
Tic 19.68 10.52 22 67260 2036 34887613
Scratch 19.58 10.52 28 67254 3320 34886329
Aspirin-exacerbated respiratory disease 19.36 10.52 11 67271 376 34889273
Nasal polyps 19.36 10.52 24 67258 2479 34887170
Gastric ulcer perforation 18.89 10.52 16 67266 1052 34888597
Skin haemorrhage 18.87 10.52 33 67249 4645 34885004
Anger 18.85 10.52 58 67224 11826 34877823
Skin fissures 18.55 10.52 35 67247 5224 34884425
Depressed mood 18.49 10.52 80 67202 19237 34870412
Respiratory muscle weakness 18.49 10.52 7 67275 91 34889558
Hyperleukocytosis 18.46 10.52 21 67261 1981 34887668
Poverty of speech 18.33 10.52 9 67273 227 34889422
Off label use 18.22 10.52 643 66639 418881 34470768
Injection site pain 18.16 10.52 133 67149 38872 34850777
Sensorimotor disorder 18.01 10.52 11 67271 431 34889218
Encephalopathy 17.99 10.52 25 67257 35294 34854355
Ventricular fibrillation 17.89 10.52 11 67271 22943 34866706
Sinus operation 17.87 10.52 13 67269 684 34888965
Adenoidal hypertrophy 17.86 10.52 8 67274 163 34889486
Cardiac failure congestive 17.80 10.52 91 67191 83179 34806470
Gastroenteritis viral 17.63 10.52 41 67241 7083 34882566
Lymphocyte percentage decreased 17.39 10.52 21 67261 2111 34887538
Oral allergy syndrome 17.36 10.52 5 67277 25 34889624
Abdominal pain upper 17.28 10.52 212 67070 71278 34818371
Impaired quality of life 17.24 10.52 36 67246 5782 34883867
Neutropenia 17.18 10.52 206 67076 156572 34733077
Arthralgia 17.01 10.52 438 66844 169603 34720046
Injection 16.99 10.52 4 67278 7 34889642
Bronchial disorder 16.98 10.52 17 67265 1386 34888263
Blood creatinine increased 16.97 10.52 110 67172 94866 34794783
Shock 16.97 10.52 13 67269 24166 34865483
Swollen tongue 16.78 10.52 64 67218 14541 34875108
Treatment failure 16.72 10.52 41 67241 46656 34842993
Frenulum breve 16.64 10.52 4 67278 8 34889641
Postmortem blood drug level 16.62 10.52 8 67274 193 34889456
Abdominal discomfort 16.49 10.52 182 67100 59653 34829996
Infusion site swelling 16.09 10.52 22 67260 2502 34887147
Memory impairment 15.96 10.52 140 67142 43178 34846471
Metabolic acidosis 15.91 10.52 38 67244 43642 34846007
Deep vein thrombosis 15.89 10.52 68 67214 65180 34824469
Bronchospasm 15.76 10.52 51 67231 10680 34878969
Blister 15.65 10.52 86 67196 22772 34866877
Specific gravity urine increased 15.56 10.52 7 67275 144 34889505
Peritonitis 15.55 10.52 6 67276 16359 34873290
Eosinophilic oesophagitis 15.52 10.52 9 67273 320 34889329
Skin exfoliation 15.43 10.52 98 67184 27334 34862315
Oropharyngeal pain 15.39 10.52 119 67163 35366 34854283
Increased upper airway secretion 15.05 10.52 18 67264 1792 34887857
Labelled drug-drug interaction medication error 15.01 10.52 5 67277 14934 34874715
Eye irritation 15.00 10.52 40 67242 7521 34882128
Phlebotomy 14.89 10.52 6 67276 93 34889556
Neutrophil percentage increased 14.86 10.52 18 67264 1815 34887834
Rhabdomyolysis 14.85 10.52 74 67208 68089 34821560
Micropenis 14.66 10.52 5 67277 47 34889602
Neutrophil count decreased 14.55 10.52 50 67232 51054 34838595
Haemoglobin decreased 14.28 10.52 156 67126 120616 34769033
Haematuria 14.24 10.52 49 67233 50017 34839632
Croup infectious 14.13 10.52 9 67273 380 34889269
Phonophobia 14.10 10.52 7 67275 181 34889468
Dermatitis exfoliative 14.07 10.52 36 67246 6603 34883046
Peripheral swelling 14.01 10.52 216 67066 76325 34813324
Abdominoplasty 13.69 10.52 3 67279 3 34889646
Reflux nephropathy 13.64 10.52 5 67277 59 34889590
Urine analysis abnormal 13.61 10.52 18 67264 1983 34887666
Blood bilirubin increased 13.41 10.52 34 67248 38262 34851387
Pneumocystis jirovecii pneumonia 13.32 10.52 11 67271 19699 34869950
Cerebral haemorrhage 13.04 10.52 30 67252 34907 34854742
Skin plaque 13.04 10.52 28 67254 4586 34885063
Metastases to liver 13.00 10.52 5 67277 13658 34875991
Product quality issue 12.97 10.52 66 67216 16969 34872680
Seizure 12.89 10.52 278 67004 104579 34785070
Dystonia 12.85 10.52 48 67234 10797 34878852
Food allergy 12.70 10.52 15 67267 1473 34888176
Hypoglycaemia 12.67 10.52 58 67224 54582 34835067
Myocardial oedema 12.66 10.52 7 67275 227 34889422
Throat clearing 12.51 10.52 8 67274 340 34889309
Injection site reaction 12.49 10.52 54 67228 12979 34876670
Eye swelling 12.48 10.52 45 67237 9950 34879699
Injection related reaction 12.39 10.52 8 67274 346 34889303
Temperature intolerance 12.35 10.52 23 67259 3399 34886250
Periorbital discomfort 12.29 10.52 4 67278 32 34889617
Pharyngitis streptococcal 12.24 10.52 20 67262 2664 34886985
Respiratory arrest 12.24 10.52 22 67260 28021 34861628
Drug intolerance 12.22 10.52 66 67216 59504 34830145
Swelling 12.19 10.52 130 67152 42236 34847413
Brugada syndrome 12.16 10.52 11 67271 790 34888859
Neuroleptic malignant syndrome 12.13 10.52 10 67272 17924 34871725
Dizziness 12.09 10.52 525 66757 217996 34671653
Upper gastrointestinal haemorrhage 12.08 10.52 19 67263 25499 34864150
Osteonecrosis of jaw 12.07 10.52 10 67272 17879 34871770
Rhinitis 12.04 10.52 33 67249 6305 34883344
Cardio-respiratory arrest 12.04 10.52 60 67222 55213 34834436
Infusion site pruritus 11.90 10.52 11 67271 812 34888837
Urethritis noninfective 11.88 10.52 3 67279 8 34889641
Nightmare 11.84 10.52 57 67225 14334 34875315
Pseudoporphyria 11.83 10.52 8 67274 374 34889275
Thrombotic microangiopathy 11.70 10.52 3 67279 10627 34879022
Urine albumin/creatinine ratio 11.62 10.52 3 67279 9 34889640
Crying 11.62 10.52 31 67251 5831 34883818
Blood urea nitrogen/creatinine ratio decreased 11.60 10.52 4 67278 39 34889610
Pharyngeal paraesthesia 11.58 10.52 10 67272 675 34888974
Hyperkalaemia 11.58 10.52 82 67200 69307 34820342
Hypercapnic coma 11.55 10.52 6 67276 171 34889478
Hyperventilation 11.49 10.52 20 67262 2804 34886845
Hereditary angioedema 11.43 10.52 12 67270 1035 34888614
Aggression 11.42 10.52 120 67162 38844 34850805
Blood creatine phosphokinase increased 11.39 10.52 46 67236 44811 34844838
Acute myeloid leukaemia 11.39 10.52 11 67271 18259 34871390
Penile erythema 11.27 10.52 6 67276 180 34889469
Mycobacterial infection 11.25 10.52 18 67264 2356 34887293
Complex regional pain syndrome 11.08 10.52 9 67273 558 34889091
Respiratory depression 11.06 10.52 9 67273 16236 34873413
Arrhythmia 10.91 10.52 34 67248 35774 34853875
Swelling of eyelid 10.84 10.52 12 67270 1099 34888550
Respiratory tract infection 10.82 10.52 70 67212 19642 34870007
Amino acid level increased 10.78 10.52 8 67274 434 34889215
Genital haemorrhage 10.75 10.52 6 67276 198 34889451
Amino acid level decreased 10.73 10.52 5 67277 112 34889537
Hyperbilirubinaemia 10.66 10.52 10 67272 16833 34872816
Multiple allergies 10.61 10.52 20 67262 2983 34886666
Synovitis 10.61 10.52 7 67275 14059 34875590

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1830.40 10.08 2081 304362 97501 79340444
Glossodynia 1641.21 10.08 2004 304439 101333 79336612
Systemic lupus erythematosus 1615.84 10.08 2154 304289 118995 79318950
Hand deformity 1480.74 10.08 1909 304534 102010 79335935
Pericarditis 1415.45 10.08 1870 304573 102366 79335579
Anti-cyclic citrullinated peptide antibody positive 1226.14 10.08 1554 304889 81589 79356356
Wound 1164.62 10.08 1804 304639 114375 79323570
Alopecia 1155.97 10.08 2666 303777 228689 79209256
Hypersensitivity 1122.02 10.08 2846 303597 259393 79178552
Swelling 1121.08 10.08 2532 303911 214179 79223766
Discomfort 1033.49 10.08 1784 304659 123833 79314112
Abdominal discomfort 1015.61 10.08 2666 303777 248061 79189884
Duodenal ulcer perforation 935.84 10.08 1212 305231 64999 79372946
Urticaria 907.88 10.08 2119 304324 183082 79254863
Helicobacter infection 891.45 10.08 1215 305228 68489 79369456
Pruritus 883.64 10.08 3420 303023 391228 79046717
Synovitis 866.20 10.08 1838 304605 148896 79289049
Arthropathy 840.38 10.08 2001 304442 175110 79262835
Blister 800.60 10.08 1553 304890 117923 79320022
Folliculitis 773.59 10.08 1008 305435 54372 79383573
Contraindicated product administered 766.95 10.08 1798 304645 155740 79282205
Muscle injury 762.53 10.08 937 305506 47624 79390321
Irritable bowel syndrome 740.59 10.08 1048 305395 61193 79376752
Infusion related reaction 734.15 10.08 2246 304197 227991 79209954
Hepatic enzyme increased 709.63 10.08 1913 304530 180697 79257248
Death 666.07 10.08 718 305725 565796 78872149
Sleep disorder due to general medical condition, insomnia type 651.10 10.08 820 305623 42736 79395209
Acute kidney injury 616.33 10.08 653 305790 518751 78919194
Maternal exposure during pregnancy 606.09 10.08 1504 304939 135034 79302911
Lower respiratory tract infection 584.77 10.08 1434 305009 127786 79310159
Rash 583.09 10.08 4008 302435 574350 78863595
Sinusitis 570.42 10.08 1850 304593 193651 79244294
Rheumatoid factor positive 560.13 10.08 901 305542 58938 79379007
Toxicity to various agents 543.70 10.08 492 305951 421048 79016897
Drug intolerance 523.09 10.08 2205 304238 261914 79176031
Anaemia 521.53 10.08 565 305878 444450 78993495
Pain 483.10 10.08 4465 301978 699337 78738608
Joint swelling 475.71 10.08 2282 304161 286364 79151581
Asthma 471.03 10.08 1361 305082 133734 79304211
Therapeutic product effect decreased 454.89 10.08 1525 304918 162338 79275607
Impaired healing 452.16 10.08 1024 305419 86631 79351314
Drug interaction 444.65 10.08 566 305877 414617 79023328
Completed suicide 404.76 10.08 220 306223 245547 79192398
Ill-defined disorder 377.62 10.08 803 305640 65072 79372873
Rheumatic fever 352.09 10.08 489 305954 28036 79409909
Hypotension 322.79 10.08 763 305680 439554 78998391
Neutropenia 314.27 10.08 386 306057 287324 79150621
Dermatitis atopic 311.28 10.08 279 306164 9777 79428168
Sepsis 285.36 10.08 370 306073 269058 79168887
Fatigue 284.89 10.08 5081 301362 924646 78513299
Swollen joint count increased 279.92 10.08 391 306052 22536 79415409
Hip arthroplasty 271.91 10.08 491 305952 35265 79402680
Stomatitis 266.96 10.08 1195 305248 145562 79292383
Product use issue 265.63 10.08 1543 304900 208279 79229666
Thrombocytopenia 261.11 10.08 384 306059 264875 79173070
Gastrointestinal disorder 257.02 10.08 1040 305403 121165 79316780
Knee arthroplasty 253.39 10.08 532 305911 42716 79395229
Food allergy 249.06 10.08 255 306188 10569 79427376
Fall 232.87 10.08 1023 305420 486606 78951339
Multiple organ dysfunction syndrome 228.37 10.08 88 306355 120158 79317787
Type 2 diabetes mellitus 221.06 10.08 598 305845 56524 79381421
Pneumonia 219.54 10.08 1561 304882 658685 78779260
Cardiac failure 218.69 10.08 165 306278 154677 79283268
Pancytopenia 218.64 10.08 189 306254 165556 79272389
Renal impairment 216.67 10.08 173 306270 157610 79280335
Renal failure 215.80 10.08 273 306170 200695 79237250
Malignant neoplasm progression 214.77 10.08 128 306315 135862 79302083
Sleep terror 205.76 10.08 156 306287 4302 79433643
Disease progression 201.55 10.08 247 306196 184115 79253830
Febrile neutropenia 201.43 10.08 362 306081 230637 79207308
Gastrointestinal haemorrhage 196.59 10.08 167 306276 147552 79290393
Nasopharyngitis 196.55 10.08 1656 304787 252225 79185720
Hyponatraemia 194.70 10.08 238 306205 177610 79260335
Blood cholesterol increased 188.49 10.08 728 305715 82992 79354953
Temperature regulation disorder 186.34 10.08 165 306278 5688 79432257
Platelet count decreased 184.55 10.08 289 306154 194375 79243570
Coeliac disease 184.53 10.08 223 306220 11128 79426817
Angioedema 183.45 10.08 676 305767 75359 79362586
Respiratory failure 182.77 10.08 257 306186 180654 79257291
Contusion 181.65 10.08 1084 305359 147692 79290253
Peripheral swelling 180.60 10.08 1704 304739 267913 79170032
Interstitial lung disease 174.98 10.08 108 306335 112492 79325453
Cardiac arrest 169.39 10.08 249 306194 171847 79266098
Treatment failure 166.98 10.08 1175 305268 169311 79268634
Septic shock 166.89 10.08 136 306307 122665 79315280
Headache 163.81 10.08 3468 302975 650304 78787641
Haemoglobin decreased 163.19 10.08 384 306059 221735 79216210
Wheezing 158.08 10.08 874 305569 115790 79322155
Cardio-respiratory arrest 155.29 10.08 114 306329 108396 79329549
Infection 154.11 10.08 1512 304931 240200 79197745
Pruritus genital 153.96 10.08 132 306311 4354 79433591
Blood creatinine increased 152.93 10.08 224 306219 154833 79283112
Eye pruritus 150.72 10.08 278 306165 20292 79417653
Metabolic acidosis 149.23 10.08 65 306378 82464 79355481
Cardiospasm 149.02 10.08 114 306329 3187 79434758
Atrial fibrillation 147.85 10.08 339 306104 197547 79240398
Cardiac failure congestive 145.11 10.08 201 306242 142201 79295744
Weight increased 143.17 10.08 1663 304780 275723 79162222
Fibromyalgia 141.98 10.08 556 305887 63784 79374161
Leukopenia 141.68 10.08 143 306300 116370 79321575
International normalised ratio increased 140.56 10.08 75 306368 84646 79353299
Rhabdomyolysis 140.40 10.08 114 306329 103017 79334928
Palmoplantar keratoderma 132.98 10.08 112 306331 3604 79434341
Depressed level of consciousness 131.37 10.08 107 306336 96545 79341400
Arthralgia 126.90 10.08 2982 303461 568821 78869124
Bursitis 123.68 10.08 360 306083 35484 79402461
Injury 122.49 10.08 606 305837 76890 79361055
Drug resistance 121.65 10.08 11 306432 42202 79395743
Ascites 120.86 10.08 70 306373 75492 79362453
Prescribed overdose 120.79 10.08 370 306073 37513 79400432
Lip swelling 120.73 10.08 389 306054 40522 79397423
Hyperkalaemia 120.06 10.08 158 306285 114240 79323705
Hepatic function abnormal 119.41 10.08 66 306377 73041 79364904
Night sweats 116.41 10.08 452 305991 51643 79386302
Liver injury 115.14 10.08 477 305966 56137 79381808
Bone marrow failure 113.90 10.08 28 306415 51079 79386866
Pleural effusion 112.45 10.08 244 306199 145018 79292927
Myocardial infarction 112.12 10.08 349 306094 183780 79254165
Psoriatic arthropathy 111.48 10.08 593 305850 77406 79360539
Anosmia 103.76 10.08 148 306295 8696 79429249
Ear pain 101.98 10.08 318 306125 32551 79405394
Hypoglycaemia 100.90 10.08 146 306297 101448 79336497
Crystal urine present 98.40 10.08 75 306368 2085 79435860
Facial pain 98.25 10.08 173 306270 12177 79425768
Lactic acidosis 97.99 10.08 76 306367 70283 79367662
Adverse drug reaction 97.79 10.08 509 305934 65883 79372062
Haemorrhage 96.48 10.08 125 306318 90993 79346952
Haematuria 96.32 10.08 74 306369 68762 79369183
Tension headache 95.60 10.08 128 306315 7083 79430862
Lip dry 94.20 10.08 193 306250 15225 79422720
Immunisation 93.81 10.08 73 306370 2094 79435851
Shock 92.97 10.08 26 306417 43522 79394423
Abdominal pain upper 92.49 10.08 1288 305155 222531 79215414
Adjustment disorder with depressed mood 92.14 10.08 142 306301 8944 79429001
Adverse event 90.32 10.08 464 305979 59750 79378195
Cytomegalovirus infection 90.04 10.08 26 306417 42618 79395327
Cerebrovascular accident 89.90 10.08 301 306142 154991 79282954
Myelosuppression 88.02 10.08 23 306420 40273 79397672
Electric shock 87.91 10.08 59 306384 1335 79436610
Blood creatine phosphokinase increased 87.54 10.08 75 306368 66015 79371930
Deep vein thrombosis postoperative 87.33 10.08 152 306291 10600 79427345
Autoimmune disorder 85.50 10.08 194 306249 16418 79421527
Drug abuse 85.12 10.08 329 306114 162362 79275583
Atrial tachycardia 84.61 10.08 120 306323 7013 79430932
Off label use 83.82 10.08 2754 303689 904461 78533484
Diarrhoea 83.45 10.08 2664 303779 877825 78560120
Immunodeficiency 83.30 10.08 227 306216 21541 79416404
Facet joint syndrome 83.12 10.08 153 306290 11149 79426796
Melaena 82.00 10.08 68 306375 60822 79377123
Hepatic failure 81.65 10.08 69 306374 61143 79376802
White blood cell count decreased 81.40 10.08 409 306034 187879 79250066
Pain of skin 81.24 10.08 176 306267 14437 79423508
Disseminated intravascular coagulation 81.12 10.08 19 306424 35823 79402122
Encephalopathy 80.46 10.08 84 306359 67313 79370632
Neurotoxicity 80.34 10.08 14 306429 32504 79405441
Acute myocardial infarction 80.21 10.08 107 306336 76929 79361016
Intentional product use issue 80.18 10.08 916 305527 151196 79286749
Blood bilirubin increased 79.69 10.08 82 306361 66150 79371795
Pneumonia aspiration 79.35 10.08 84 306359 66883 79371062
Serotonin syndrome 78.99 10.08 37 306406 44990 79392955
Infective pulmonary exacerbation of cystic fibrosis 78.67 10.08 161 306282 12690 79425255
Coma 77.10 10.08 170 306273 100479 79337466
Exposure during pregnancy 76.71 10.08 657 305786 100475 79337470
Prostate cancer 76.56 10.08 17 306426 33251 79404694
Dry skin 76.35 10.08 485 305958 67510 79370435
Sleep disorder 76.07 10.08 577 305866 85100 79352845
Urinary sediment present 75.83 10.08 69 306374 2466 79435479
Carotid artery occlusion 75.44 10.08 118 306325 7529 79430416
Respiratory arrest 75.39 10.08 66 306377 57484 79380461
Rash erythematous 75.03 10.08 428 306015 57341 79380604
Acute myeloid leukaemia 74.78 10.08 14 306429 30871 79407074
Migraine 74.22 10.08 583 305860 86910 79351035
Hypokalaemia 73.61 10.08 294 306149 143746 79294199
Skin ulcer 73.51 10.08 60 306383 54090 79383855
Anaphylactic reaction 73.24 10.08 562 305881 83181 79354764
Respiratory disorder 73.18 10.08 354 306089 44502 79393443
Cardiogenic shock 72.67 10.08 35 306408 41879 79396066
Urine leukocyte esterase positive 72.50 10.08 84 306359 4007 79433938
Neutrophil count decreased 71.73 10.08 159 306284 93800 79344145
Eczema 70.87 10.08 328 306115 40490 79397455
Urine abnormality 70.45 10.08 119 306324 8100 79429845
Anti-cyclic citrullinated peptide antibody 70.23 10.08 99 306344 5753 79432192
Hypercalcaemia 69.89 10.08 30 306413 38400 79399545
Urinary tract infection 69.26 10.08 697 305746 273815 79164130
White blood cells urine positive 68.83 10.08 100 306343 5975 79431970
Cerebral haemorrhage 68.71 10.08 72 306371 57601 79380344
Muscle spasticity 68.69 10.08 210 306233 21265 79416680
Overdose 67.72 10.08 422 306021 183784 79254161
Lymphocyte percentage decreased 66.99 10.08 89 306354 4887 79433058
Pulmonary oedema 66.02 10.08 151 306292 88103 79349842
Temperature intolerance 65.93 10.08 127 306316 9578 79428367
Live birth 65.37 10.08 189 306254 18555 79419390
Cerebral infarction 65.32 10.08 48 306395 45628 79392317
Throat irritation 65.26 10.08 321 306122 40625 79397320
Upper gastrointestinal haemorrhage 65.23 10.08 39 306404 41341 79396604
Dehydration 65.19 10.08 624 305819 247563 79190382
Maternal exposure timing unspecified 65.13 10.08 95 306348 5697 79432248
Dislocation of vertebra 64.78 10.08 112 306331 7768 79430177
Mental status changes 64.75 10.08 98 306345 66861 79371084
Bradycardia 64.73 10.08 284 306159 135273 79302672
Anticipatory anxiety 64.28 10.08 46 306397 1158 79436787
Pulmonary embolism 64.27 10.08 391 306052 171263 79266682
Retinitis 64.10 10.08 93 306350 5550 79432395
Haemoglobin urine present 64.05 10.08 42 306401 913 79437032
Altered state of consciousness 64.04 10.08 45 306398 43777 79394168
Insomnia 63.84 10.08 1309 305134 243861 79194084
Orthostatic hypotension 63.73 10.08 73 306370 56091 79381854
Chronic sinusitis 63.60 10.08 149 306294 12877 79425068
Renal tubular necrosis 63.59 10.08 10 306433 25029 79412916
Labelled drug-drug interaction medication error 61.90 10.08 15 306428 27635 79410310
Swelling face 61.21 10.08 476 305967 70736 79367209
Thrombosis 60.43 10.08 147 306296 83953 79353992
Oedema peripheral 60.19 10.08 649 305794 251639 79186306
Grip strength decreased 60.09 10.08 203 306240 21666 79416279
Pregnancy 60.00 10.08 233 306210 26618 79411327
Osteonecrosis of jaw 59.80 10.08 47 306396 43179 79394766
Haematochezia 59.27 10.08 158 306285 87487 79350458
Loss of consciousness 59.04 10.08 390 306053 167553 79270392
Asthenia 59.01 10.08 1506 304937 510183 78927762
Forced expiratory volume decreased 59.00 10.08 107 306336 7707 79430238
Hyperglycaemia 58.78 10.08 113 306330 70222 79367723
Body temperature increased 58.27 10.08 330 306113 44090 79393855
Pericardial effusion 58.21 10.08 55 306388 46182 79391763
Musculoskeletal stiffness 57.57 10.08 969 305474 174039 79263906
Unresponsive to stimuli 57.55 10.08 78 306365 55710 79382235
Blood lactate dehydrogenase increased 57.53 10.08 40 306403 39130 79398815
Urine analysis abnormal 56.68 10.08 95 306348 6425 79431520
Ventricular fibrillation 56.36 10.08 26 306417 31900 79406045
Neutrophil percentage increased 55.79 10.08 79 306364 4610 79433335
Peritonitis 55.78 10.08 19 306424 28017 79409928
Shock haemorrhagic 55.78 10.08 6 306437 20054 79417891
Neoplasm progression 55.63 10.08 70 306373 51612 79386333
Pneumocystis jirovecii pneumonia 55.06 10.08 28 306415 32480 79405465
Hepatotoxicity 54.81 10.08 70 306373 51282 79386663
Rheumatoid nodule 54.70 10.08 3 306440 17435 79420510
Bacteraemia 54.52 10.08 29 306414 32795 79405150
Victim of chemical submission 54.16 10.08 31 306412 523 79437422
Red blood cells urine positive 53.78 10.08 80 306363 4883 79433062
Thrombotic microangiopathy 53.68 10.08 7 306436 20162 79417783
Skin plaque 53.66 10.08 124 306319 10621 79427324
Liver function test abnormal 53.52 10.08 104 306339 64371 79373574
Alanine aminotransferase increased 53.45 10.08 385 306058 162185 79275760
Plasma cell myeloma 53.40 10.08 76 306367 53183 79384762
Peripheral venous disease 53.17 10.08 158 306285 15751 79422194
Amnesia 52.82 10.08 419 306024 62638 79375307
Respiratory depression 52.80 10.08 20 306423 27610 79410335
Neuroleptic malignant syndrome 52.58 10.08 20 306423 27539 79410406
Intentional overdose 52.42 10.08 219 306224 105741 79332204
Ear infection 52.09 10.08 266 306177 34166 79403779
Urticaria chronic 51.58 10.08 31 306412 575 79437370
Chronic kidney disease 51.27 10.08 111 306332 66043 79371902
Posterior reversible encephalopathy syndrome 50.26 10.08 19 306424 26262 79411683
Paraesthesia oral 50.19 10.08 183 306260 20288 79417657
Blood pressure fluctuation 50.13 10.08 115 306328 67030 79370915
Dry mouth 49.99 10.08 538 305905 87481 79350464
Transaminases increased 49.77 10.08 76 306367 51667 79386278
Agranulocytosis 49.51 10.08 60 306383 44970 79392975
Type I hypersensitivity 49.26 10.08 72 306371 4326 79433619
Post-traumatic stress disorder 49.10 10.08 76 306367 4805 79433140
Mucosal inflammation 49.05 10.08 139 306304 75441 79362504
Blood immunoglobulin E increased 48.88 10.08 84 306359 5798 79432147
Cellulitis 48.78 10.08 234 306209 108826 79329119
Aspartate aminotransferase increased 48.70 10.08 322 306121 138319 79299626
Vocal cord dysfunction 48.60 10.08 30 306413 585 79437360
Oral allergy syndrome 48.49 10.08 17 306426 79 79437866
Premature delivery 48.28 10.08 15 306428 23452 79414493
Erythema 48.25 10.08 1161 305282 222129 79215816
Constipation 48.15 10.08 781 305662 282269 79155676
Hereditary angioedema 48.07 10.08 79 306364 5256 79432689
Oral pruritus 48.04 10.08 53 306390 2395 79435550
Syncope 48.03 10.08 449 305994 179000 79258945
Proteinuria 47.99 10.08 33 306410 32469 79405476
Hypocalcaemia 47.38 10.08 74 306369 49850 79388095
Psychotic disorder 46.77 10.08 54 306389 41348 79396597
Hypoxia 46.48 10.08 221 306222 103022 79334923
Ileus 45.27 10.08 22 306421 26189 79411756
Acute respiratory distress syndrome 45.06 10.08 62 306381 44005 79393940
Neuropathy peripheral 44.84 10.08 338 306105 140967 79296978
Hypoaesthesia 44.84 10.08 952 305491 178400 79259545
Rectal haemorrhage 44.75 10.08 147 306296 76153 79361792
Mastocytosis 44.26 10.08 27 306416 515 79437430
Haematemesis 43.64 10.08 84 306359 52180 79385765
Electrolyte imbalance 43.45 10.08 33 306410 30848 79407097
Scratch 43.41 10.08 98 306345 8265 79429680
Palmar-plantar erythrodysaesthesia syndrome 43.39 10.08 38 306405 33096 79404849
Myelodysplastic syndrome 43.12 10.08 32 306411 30269 79407676
Coronary artery disease 42.79 10.08 120 306323 65354 79372591
Arrhythmia 42.53 10.08 109 306334 61163 79376782
Chronic spontaneous urticaria 41.97 10.08 36 306407 1188 79436757
Sedation 41.96 10.08 85 306358 51810 79386135
Seasonal allergy 41.35 10.08 148 306295 16258 79421687
Drug level increased 41.34 10.08 55 306388 39596 79398349
Acute hepatic failure 41.33 10.08 33 306410 30080 79407865
Creatinine renal clearance decreased 41.21 10.08 11 306432 18991 79418954
Rheumatoid arthritis 40.90 10.08 1070 305373 207400 79230545
Basal cell carcinoma 40.88 10.08 50 306393 37325 79400620
Transplant rejection 40.76 10.08 12 306431 19425 79418520
Epistaxis 40.69 10.08 256 306187 111259 79326686
Restrictive pulmonary disease 40.59 10.08 50 306393 2545 79435400
Nausea 40.52 10.08 3149 303294 954047 78483898
Anuria 40.35 10.08 15 306428 20948 79416997
Metastases to liver 40.17 10.08 30 306413 28284 79409661
Cardiomyopathy 40.16 10.08 31 306412 28743 79409202
Haematotoxicity 39.86 10.08 6 306437 15513 79422432
Gamma-glutamyltransferase increased 39.73 10.08 95 306348 54585 79383360
Deep vein thrombosis 39.43 10.08 287 306156 120632 79317313
Extrapyramidal disorder 39.22 10.08 19 306424 22660 79415285
Osteomyelitis 39.18 10.08 41 306402 32824 79405121
Laryngitis 39.00 10.08 143 306300 15896 79422049
Status epilepticus 38.91 10.08 24 306419 25017 79412928
Perfume sensitivity 38.90 10.08 30 306413 849 79437096
Left ventricular dysfunction 38.73 10.08 13 306430 19348 79418597
Neoplasm malignant 38.70 10.08 39 306404 31771 79406174
Muscle twitching 38.65 10.08 193 306250 24571 79413374
Joint range of motion decreased 38.35 10.08 239 306204 33043 79404902
Product prescribing error 38.32 10.08 71 306372 44742 79393203
Renal injury 38.25 10.08 9 306434 16918 79421027
Hip fracture 38.24 10.08 37 306406 30724 79407221
Oliguria 38.21 10.08 8 306435 16301 79421644
Upper respiratory tract infection 38.15 10.08 526 305917 90642 79347303
Leukocytosis 37.91 10.08 68 306375 43387 79394558
Somnolence 37.84 10.08 668 305775 238313 79199632
Subdural haematoma 37.72 10.08 39 306404 31395 79406550
Subarachnoid haemorrhage 37.71 10.08 190 306253 24275 79413670
Coagulopathy 37.48 10.08 50 306393 35956 79401989
Obesity 37.25 10.08 247 306196 34878 79403067
Breast cancer stage III 37.13 10.08 102 306341 9724 79428221
Tachypnoea 37.11 10.08 41 306402 32022 79405923
Metastases to central nervous system 36.43 10.08 9 306434 16366 79421579
Angina pectoris 35.93 10.08 92 306351 51640 79386305
Inappropriate antidiuretic hormone secretion 35.90 10.08 29 306414 26284 79411661
Vomiting 35.86 10.08 2144 304299 663684 78774261
Pathogen resistance 35.81 10.08 6 306437 14336 79423609
Cardiotoxicity 35.78 10.08 3 306440 12236 79425709
Eye swelling 35.62 10.08 198 306245 26270 79411675
Haematoma 35.35 10.08 94 306349 52101 79385844
Haemodialysis 34.97 10.08 13 306430 18155 79419790
Pulmonary pain 34.73 10.08 62 306381 4411 79433534
Skin necrosis 34.72 10.08 13 306430 18074 79419871
Diabetes mellitus 34.58 10.08 169 306274 78221 79359724
Seizure 34.47 10.08 514 305929 188320 79249625
Herpes zoster 34.32 10.08 213 306230 92870 79345075
Chest discomfort 34.25 10.08 732 305711 137312 79300633
Decreased appetite 34.21 10.08 1028 305415 341390 79096555
Femur fracture 34.16 10.08 60 306383 38592 79399353
Cardiac failure acute 34.06 10.08 15 306428 18914 79419031
Respiratory distress 33.79 10.08 113 306330 58226 79379719
Fracture 33.73 10.08 21 306422 21780 79416165
Rash papular 33.64 10.08 170 306273 21746 79416199
C-reactive protein 33.63 10.08 65 306378 4914 79433031
Head deformity 33.50 10.08 11 306432 40 79437905
Hyper IgE syndrome 33.24 10.08 23 306420 548 79437397
Metastases to bone 33.23 10.08 27 306416 24400 79413545
Haemorrhage intracranial 33.15 10.08 31 306412 26162 79411783
Pulmonary hypertension 33.01 10.08 86 306357 47994 79389951
Dialysis 32.64 10.08 15 306428 18447 79419498
Seronegative arthritis 32.61 10.08 62 306381 4630 79433315
Urinary retention 32.59 10.08 110 306333 56520 79381425
Intervertebral discitis 32.57 10.08 63 306380 4765 79433180
Hepatic encephalopathy 32.52 10.08 27 306416 24139 79413806
Blood pressure decreased 32.47 10.08 236 306207 99230 79338715
Klebsiella infection 32.43 10.08 10 306433 15710 79422235
Parathyroid gland enlargement 32.41 10.08 15 306428 158 79437787
Muscle rigidity 32.39 10.08 18 306425 19864 79418081
Ejection fraction decreased 32.10 10.08 52 306391 34525 79403420
Gastric haemorrhage 32.10 10.08 9 306434 15041 79422904
Immune reconstitution inflammatory syndrome 32.00 10.08 7 306436 13834 79424111
Toxic epidermal necrolysis 31.96 10.08 78 306365 44503 79393442
Hypervolaemia 31.95 10.08 73 306370 42617 79395328
Circulatory collapse 31.92 10.08 60 306383 37608 79400337
Hallucination, auditory 31.92 10.08 20 306423 20673 79417272
Throat tightness 31.90 10.08 200 306243 27707 79410238
Tumour lysis syndrome 31.90 10.08 27 306416 23912 79414033
Anxiety 31.71 10.08 1211 305232 247301 79190644
Neonatal hypoacusis 31.61 10.08 9 306434 17 79437928
Gastric ulcer 31.47 10.08 51 306392 33854 79404091
Walking aid user 31.31 10.08 98 306345 10050 79427895
Escherichia infection 31.30 10.08 15 306428 18002 79419943
Hypophagia 31.26 10.08 81 306362 45286 79392659
Colitis 31.22 10.08 160 306283 73147 79364798
Diabetic ketoacidosis 31.04 10.08 52 306391 34070 79403875
Urticaria thermal 30.90 10.08 20 306423 425 79437520
Obstructive airways disorder 30.85 10.08 217 306226 31242 79406703
Lacrimation increased 30.82 10.08 169 306274 22308 79415637
Hypothyroidism 30.68 10.08 101 306342 52291 79385654
Auditory neuropathy spectrum disorder 30.64 10.08 9 306434 20 79437925
Aspergillus infection 30.28 10.08 18 306425 19143 79418802
Myoclonus 30.26 10.08 37 306406 27623 79410322
Graft versus host disease 30.21 10.08 10 306433 15016 79422929
Blood potassium increased 30.12 10.08 41 306402 29234 79408711
Localised infection 29.99 10.08 62 306381 37513 79400432
Bladder cancer 29.94 10.08 19 306424 19507 79418438
Generalised tonic-clonic seizure 29.80 10.08 79 306364 43831 79394114
Blepharospasm 29.74 10.08 68 306375 5783 79432162
Blood parathyroid hormone decreased 29.68 10.08 3 306440 10533 79427412
Ischaemic stroke 29.67 10.08 51 306392 33080 79404865
Tremor 29.67 10.08 467 305976 169616 79268329
Blood calcium decreased 29.40 10.08 48 306395 31771 79406174
Oesophageal carcinoma 29.14 10.08 4 306439 11080 79426865
Panniculitis 29.12 10.08 6 306437 12365 79425580
Penis injury 28.85 10.08 13 306430 128 79437817
Bacterial test positive 28.82 10.08 78 306365 7371 79430574
Metastases to lung 28.79 10.08 17 306426 18146 79419799
Intestinal obstruction 28.74 10.08 78 306365 42942 79395003
Forced expiratory volume 28.68 10.08 12 306431 97 79437848
Enthesopathy 28.67 10.08 5 306438 11603 79426342
Haemophagocytic lymphohistiocytosis 28.65 10.08 25 306418 21812 79416133
Cytomegalovirus viraemia 28.61 10.08 7 306436 12814 79425131
Electrocardiogram QT prolonged 28.29 10.08 217 306226 90169 79347776
Intestinal ischaemia 28.18 10.08 8 306435 13262 79424683
Pain in extremity 28.18 10.08 1130 305313 363408 79074537
Post cholecystectomy syndrome 28.16 10.08 18 306425 374 79437571
Tubulointerstitial nephritis 28.12 10.08 66 306377 38169 79399776
Lupus vulgaris 28.09 10.08 48 306395 3298 79434647
Second primary malignancy 28.07 10.08 10 306433 14340 79423605
Drug use disorder 28.04 10.08 85 306358 8566 79429379
Haemodynamic instability 27.94 10.08 16 306427 17366 79420579
Mobility decreased 27.82 10.08 640 305803 121535 79316410
Middle insomnia 27.79 10.08 129 306314 15940 79422005
Encephalitis 27.68 10.08 11 306432 14749 79423196
Hyperbilirubinaemia 27.67 10.08 32 306411 24486 79413459
Pregnancy on contraceptive 27.55 10.08 25 306418 890 79437055
Hepatic cancer 27.21 10.08 4 306439 10525 79427420
Stress cardiomyopathy 27.16 10.08 5 306438 11161 79426784
Joint dislocation 27.13 10.08 133 306310 16806 79421139
Sinus disorder 26.94 10.08 163 306280 22301 79415644
Lower limb fracture 26.93 10.08 167 306276 23048 79414897
Sudden death 26.93 10.08 28 306415 22483 79415462
Osteonecrosis 26.82 10.08 49 306394 31046 79406899
Heparin-induced thrombocytopenia 26.65 10.08 3 306440 9679 79428266
Weight decreased 26.61 10.08 1105 305338 354093 79083852
Potassium wasting nephropathy 26.53 10.08 13 306430 157 79437788
Nasal turbinate hypertrophy 26.52 10.08 22 306421 693 79437252
Mast cell activation syndrome 26.38 10.08 22 306421 698 79437247
Nasal congestion 26.31 10.08 427 306016 76125 79361820
Mechanical urticaria 26.30 10.08 18 306425 421 79437524
Cholestasis 26.20 10.08 107 306336 52002 79385943
Bronchial neoplasm 26.19 10.08 19 306424 489 79437456
Renal disorder 26.18 10.08 79 306364 42026 79395919
Hallucination, visual 26.12 10.08 54 306389 32675 79405270
Agitation 26.03 10.08 251 306192 99464 79338481
Cytopenia 25.94 10.08 24 306419 20359 79417586
Blood urea increased 25.93 10.08 98 306345 48692 79389253
Lichen sclerosus 25.79 10.08 25 306418 969 79436976
X-ray abnormal 25.71 10.08 64 306379 5749 79432196
Cestode infection 25.70 10.08 15 306428 263 79437682
Cataract 25.66 10.08 137 306306 61983 79375962
Enteritis 25.55 10.08 12 306431 14571 79423374
Pancreatitis acute 25.48 10.08 101 306342 49503 79388442
Victim of sexual abuse 25.40 10.08 19 306424 513 79437432
Sudden infant death syndrome 25.35 10.08 15 306428 270 79437675
Acute respiratory failure 25.33 10.08 130 306313 59411 79378534
Lupus-like syndrome 25.28 10.08 113 306330 13744 79424201
Therapy cessation 25.17 10.08 68 306375 37494 79400451
Memory impairment 25.04 10.08 584 305859 111150 79326795
Substance abuse 25.00 10.08 5 306438 10521 79427424
Blood alkaline phosphatase increased 24.88 10.08 143 306300 63521 79374424
Granuloma skin 24.86 10.08 3 306440 9171 79428774
Exposure via body fluid 24.80 10.08 16 306427 338 79437607
Exostosis 24.64 10.08 129 306314 16729 79421216
Diffuse large B-cell lymphoma 24.58 10.08 8 306435 12141 79425804
Hypomagnesaemia 24.43 10.08 95 306348 46816 79391129
Tuberculosis 24.41 10.08 14 306429 15184 79422761
Gangrene 24.13 10.08 3 306440 8961 79428984
Intestinal perforation 24.03 10.08 19 306424 17407 79420538
Oesophagitis 24.01 10.08 35 306408 24254 79413691
Therapy partial responder 23.95 10.08 19 306424 17378 79420567
Enterocolitis 23.84 10.08 13 306430 14499 79423446
Red cell distribution width decreased 23.75 10.08 34 306409 2004 79435941
Abdominal pain 23.75 10.08 1239 305204 388330 79049615
Disturbance in attention 23.71 10.08 299 306144 50502 79387443
Pancreatitis 23.71 10.08 160 306283 68415 79369530
Pulmonary toxicity 23.61 10.08 10 306433 12904 79425041
Epstein-Barr virus infection 23.56 10.08 13 306430 14403 79423542
Clostridium difficile colitis 23.52 10.08 56 306387 32227 79405718
Catatonia 23.40 10.08 3 306440 8753 79429192
C-reactive protein increased 23.27 10.08 352 306091 128675 79309270
Lymphocyte count decreased 23.22 10.08 281 306162 47008 79390937
Pallor 23.21 10.08 106 306337 49956 79387989
Cystic fibrosis pancreatic 23.12 10.08 9 306434 59 79437886
Myocardial ischaemia 23.11 10.08 39 306404 25480 79412465
Pulmonary haemorrhage 23.01 10.08 14 306429 14703 79423242
Bacterial infection 23 10.08 54 306389 31226 79406719
Ataxia 22.92 10.08 38 306405 25001 79412944
Lung neoplasm malignant 22.91 10.08 45 306398 27747 79410198
Hydronephrosis 22.88 10.08 20 306423 17434 79420511
Bronchial disorder 22.62 10.08 37 306406 2452 79435493
Arteriosclerosis 22.57 10.08 22 306421 18205 79419740
Splenomegaly 22.45 10.08 28 306415 20726 79417219
Blood phosphorus increased 22.42 10.08 6 306437 10341 79427604
Suicide attempt 22.39 10.08 207 306236 82725 79355220
Duodenal ulcer 22.38 10.08 18 306425 16351 79421594
Toxic encephalopathy 22.33 10.08 8 306435 11432 79426513
Laryngeal stenosis 22.12 10.08 24 306419 1064 79436881
Drug level decreased 22.10 10.08 14 306429 14388 79423557
Immunosuppressant drug level increased 22.05 10.08 4 306439 9023 79428922
Hepatic steatosis 21.92 10.08 73 306370 37665 79400280
Gastric cancer 21.87 10.08 6 306437 10173 79427772
Parkinsonism 21.74 10.08 19 306424 16565 79421380
Fixed eruption 21.73 10.08 40 306403 2914 79435031
Confusional state 21.72 10.08 1459 304984 316538 79121407
Iron deficiency anaemia 21.66 10.08 41 306402 25631 79412314
Pulse absent 21.62 10.08 6 306437 10097 79427848
Activated partial thromboplastin time prolonged 21.61 10.08 14 306429 14214 79423731
Akathisia 21.60 10.08 12 306431 13247 79424698
Nocturnal fear 21.55 10.08 6 306437 10 79437935
Hypertensive crisis 21.46 10.08 29 306414 20741 79417204
Multiple sclerosis 21.44 10.08 153 306290 22129 79415816
Ventricular arrhythmia 21.42 10.08 4 306439 8836 79429109
Cardiac failure chronic 21.38 10.08 8 306435 11127 79426818
Abdominal distension 21.38 10.08 327 306116 119323 79318622
Malaise 21.34 10.08 2172 304271 487697 78950248
Cachexia 21.21 10.08 8 306435 11075 79426870
Hemiparesis 21.18 10.08 63 306380 33670 79404275
Pancreatic carcinoma 21.11 10.08 13 306430 13564 79424381
Skin burning sensation 21.11 10.08 104 306339 13168 79424777
Acidosis 21.02 10.08 27 306416 19735 79418210
Hemiplegia 20.97 10.08 16 306427 14923 79423022
Myopathy 20.95 10.08 29 306414 20534 79417411
Penile haemorrhage 20.91 10.08 17 306426 520 79437425
Febrile bone marrow aplasia 20.90 10.08 12 306431 13008 79424937
Hypernatraemia 20.90 10.08 15 306428 14436 79423509
Specific gravity urine increased 20.83 10.08 16 306427 450 79437495
Cardiac tamponade 20.83 10.08 5 306438 9271 79428674
Demyelination 20.76 10.08 73 306370 7950 79429995
Pulmonary alveolar haemorrhage 20.74 10.08 9 306434 11448 79426497
Pneumonitis 20.54 10.08 143 306300 60717 79377228
Cardiac disorder 20.51 10.08 158 306285 65599 79372346
Lower gastrointestinal haemorrhage 20.51 10.08 19 306424 16106 79421839
Metabolic disorder 20.48 10.08 5 306438 9165 79428780
Infusion site pain 20.39 10.08 108 306335 14068 79423877
Kidney transplant rejection 20.29 10.08 7 306436 10239 79427706
Prothrombin time prolonged 20.24 10.08 21 306422 16878 79421067
Lethargy 20.22 10.08 207 306236 81085 79356860
Bundle branch block right 20.11 10.08 9 306434 11242 79426703
Lip pruritus 20.10 10.08 21 306422 891 79437054
Treatment noncompliance 20.10 10.08 118 306325 52150 79385795
Product use in unapproved indication 20.10 10.08 1165 305278 249194 79188751
Faeces discoloured 20.07 10.08 52 306391 29075 79408870
Ileus paralytic 20.06 10.08 6 306437 9614 79428331
Upper respiratory fungal infection 19.96 10.08 14 306429 341 79437604
Pneumothorax 19.95 10.08 50 306393 28273 79409672
Dysarthria 19.93 10.08 165 306278 67457 79370488
Diverticulitis 19.71 10.08 100 306343 45836 79392109
Monocyte percentage increased 19.69 10.08 32 306411 2109 79435836
Acute graft versus host disease in skin 19.58 10.08 3 306440 7655 79430290
Peripheral sensory neuropathy 19.55 10.08 13 306430 13020 79424925
Candida infection 19.51 10.08 78 306365 38136 79399809
Alanine aminotransferase abnormal 19.48 10.08 5 306438 8862 79429083
Osteoarthritis 19.45 10.08 456 305987 86853 79351092
Eosinophilic oesophagitis 19.42 10.08 17 306426 577 79437368
Spinal compression fracture 19.28 10.08 22 306421 16936 79421009
Granulocytopenia 19.13 10.08 10 306433 11421 79426524
Lung infiltration 18.97 10.08 37 306406 22875 79415070
Malnutrition 18.93 10.08 36 306407 22466 79415479
Torsade de pointes 18.92 10.08 28 306415 19284 79418661
Heart rate decreased 18.77 10.08 176 306267 70140 79367805
Renal cancer 18.61 10.08 12 306431 12214 79425731
Blood albumin decreased 18.52 10.08 41 306402 24202 79413743
Colitis ischaemic 18.49 10.08 19 306424 15340 79422605
Pneumonia fungal 18.48 10.08 10 306433 11200 79426745
Polymenorrhoea 18.47 10.08 21 306422 981 79436964
Radiation inflammation 18.47 10.08 20 306423 885 79437060
Nitrite urine present 18.44 10.08 23 306420 1186 79436759
Menstruation delayed 18.43 10.08 25 306418 1401 79436544
Allergy test positive 18.31 10.08 18 306425 710 79437235
Gait disturbance 18.30 10.08 633 305810 206873 79231072
Brain oedema 18.27 10.08 44 306399 25219 79412726
Bacterial test 18.22 10.08 23 306420 1200 79436745
Enterococcal infection 18.15 10.08 20 306423 15640 79422305
Adenovirus infection 18.11 10.08 5 306438 8442 79429503
Faecaloma 18.08 10.08 11 306432 11553 79426392
Myocarditis 18.08 10.08 35 306408 21698 79416247
Wrong technique in product usage process 18.01 10.08 189 306254 73686 79364259
Renal cyst 17.99 10.08 18 306425 14714 79423231
Drug ineffective for unapproved indication 17.98 10.08 119 306324 51119 79386826
Hypoalbuminaemia 17.98 10.08 34 306409 21263 79416682
Tenosynovitis 17.88 10.08 20 306423 15534 79422411
Vaginal flatulence 17.86 10.08 34 306409 2541 79435404
Troponin increased 17.83 10.08 29 306414 19226 79418719
Visual acuity reduced 17.82 10.08 56 306387 29413 79408532
Gastroenteritis 17.76 10.08 69 306374 34013 79403932
Cystitis 17.75 10.08 124 306319 52608 79385337
Right ventricular failure 17.73 10.08 40 306403 23457 79414488
Blood pressure diastolic abnormal 17.71 10.08 29 306414 19173 79418772
Food intolerance 17.69 10.08 43 306400 3805 79434140
Skin toxicity 17.68 10.08 5 306438 8309 79429636
Glomerular filtration rate decreased 17.66 10.08 38 306405 22664 79415281
Acute coronary syndrome 17.61 10.08 34 306409 21099 79416846
Hepatic cytolysis 17.56 10.08 50 306393 27101 79410844
Diarrhoea haemorrhagic 17.54 10.08 15 306428 13219 79424726
Chronic obstructive pulmonary disease 17.54 10.08 227 306216 85192 79352753
Device related infection 17.50 10.08 70 306373 34224 79403721
Anal abscess 17.50 10.08 7 306436 9348 79428597
Spinal fusion surgery 17.48 10.08 52 306391 5186 79432759
Mitral valve incompetence 17.47 10.08 54 306389 28511 79409434
Pulmonary congestion 17.46 10.08 50 306393 27050 79410895
Monocyte count increased 17.29 10.08 84 306359 10577 79427368
Wound infection 17.21 10.08 154 306289 23837 79414108
Tooth disorder 17.20 10.08 48 306395 26185 79411760
Tachyarrhythmia 17.19 10.08 3 306440 6959 79430986
Mixed liver injury 17.18 10.08 4 306439 7574 79430371
Drug level below therapeutic 17.18 10.08 8 306435 9762 79428183
Angina unstable 17.15 10.08 23 306420 16504 79421441
Tricuspid valve incompetence 17.06 10.08 31 306412 19681 79418264
Diabetes mellitus inadequate control 16.96 10.08 43 306400 24221 79413724
Colorectal cancer 16.96 10.08 6 306437 8641 79429304
Endometrial ablation 16.95 10.08 19 306424 874 79437071
Hyperhidrosis 16.94 10.08 728 305715 150764 79287181
Lichen nitidus 16.90 10.08 8 306435 89 79437856
Full blood count decreased 16.90 10.08 50 306393 26769 79411176
Macular degeneration 16.90 10.08 87 306356 11209 79426736
Rhinitis 16.85 10.08 106 306337 14701 79423244
Hyperammonaemia 16.73 10.08 11 306432 11082 79426863
Myositis 16.72 10.08 30 306413 19138 79418807
Myalgia 16.67 10.08 565 305878 185076 79252869
Hyperthyroidism 16.60 10.08 38 306405 22171 79415774
Escherichia sepsis 16.52 10.08 6 306437 8502 79429443
Vasculitis 16.43 10.08 158 306285 24944 79413001
Cryopyrin associated periodic syndrome 16.32 10.08 13 306430 386 79437559
Femoral neck fracture 16.32 10.08 9 306434 9975 79427970
Ehlers-Danlos syndrome 16.31 10.08 9 306434 141 79437804
Blood lactic acid increased 16.23 10.08 15 306428 12729 79425216
Hypertriglyceridaemia 16.22 10.08 15 306428 12725 79425220
Dyskinesia 16.22 10.08 103 306340 44670 79393275
Illness 16.19 10.08 260 306183 46251 79391694
Premenstrual syndrome 16.14 10.08 15 306428 551 79437394
Congestive cardiomyopathy 16.05 10.08 13 306430 11767 79426178
Tongue pruritus 16.05 10.08 15 306428 555 79437390
Sneezing 16.05 10.08 130 306313 19553 79418392
Gastritis erosive 16.03 10.08 11 306432 10836 79427109
Electrocardiogram QRS complex prolonged 15.99 10.08 11 306432 10822 79427123
Therapy interrupted 15.98 10.08 64 306379 31277 79406668
Spinal fracture 15.98 10.08 28 306415 18026 79419919
Polyneuropathy 15.97 10.08 44 306399 24107 79413838
Pulmonary artery stenosis congenital 15.95 10.08 5 306438 15 79437930
Throat clearing 15.95 10.08 33 306410 2621 79435324
Drug eruption 15.95 10.08 101 306342 43834 79394111
Accidental exposure to product 15.95 10.08 64 306379 31258 79406687
Cardiovascular disorder 15.91 10.08 28 306415 17997 79419948
Eosinophilic colitis 15.87 10.08 14 306429 480 79437465
Prevertebral soft tissue swelling of cervical space 15.86 10.08 6 306437 36 79437909
Sopor 15.84 10.08 69 306374 32941 79405004
Generalised oedema 15.83 10.08 43 306400 23666 79414279
Motor dysfunction 15.81 10.08 20 306423 14713 79423232
Drug withdrawal syndrome 15.81 10.08 74 306369 34644 79403301
Pain in jaw 15.79 10.08 108 306335 46043 79391902
Aspartate aminotransferase 15.76 10.08 15 306428 568 79437377
Atelectasis 15.74 10.08 67 306376 32190 79405755
Unintentional medical device removal 15.74 10.08 5 306438 7707 79430238
Cerebral ischaemia 15.70 10.08 12 306431 11183 79426762
Pharyngeal swelling 15.66 10.08 65 306378 7654 79430291
Venous thrombosis 15.66 10.08 4 306439 7112 79430833
Acute pulmonary oedema 15.60 10.08 19 306424 14211 79423734
Rib fracture 15.60 10.08 55 306388 27892 79410053
Fistula 15.59 10.08 16 306427 12924 79425021
Oxygen saturation decreased 15.58 10.08 377 306066 128670 79309275
Renal tubular disorder 15.57 10.08 3 306440 6483 79431462
Red blood cell sedimentation rate abnormal 15.56 10.08 36 306407 20927 79417018
Atrioventricular block first degree 15.56 10.08 15 306428 12476 79425469
Lymphoma 15.52 10.08 27 306416 17433 79420512
Urine ketone body present 15.50 10.08 39 306404 3526 79434419
Polyuria 15.47 10.08 21 306422 14993 79422952
Blood immunoglobulin A increased 15.47 10.08 19 306424 964 79436981
Sinus tachycardia 15.46 10.08 81 306362 36827 79401118
Haemoptysis 15.45 10.08 139 306304 55860 79382085
Anal inflammation 15.42 10.08 23 306420 1407 79436538
Bilirubin urine present 15.40 10.08 12 306431 345 79437600
Large intestine perforation 15.40 10.08 20 306423 14547 79423398
Cells in urine 15.39 10.08 10 306433 214 79437731
Endophthalmitis 15.38 10.08 3 306440 6425 79431520
Pneumonia bacterial 15.34 10.08 32 306411 19299 79418646
Dyshidrotic eczema 15.33 10.08 15 306428 588 79437357
Cholecystitis chronic 15.31 10.08 77 306366 9829 79428116
Oedema 15.30 10.08 583 305860 118997 79318948
Glomerular filtration rate increased 15.30 10.08 21 306422 1190 79436755
Colon cancer 15.29 10.08 20 306423 14503 79423442
Sciatica 15.27 10.08 195 306248 33027 79404918
Hypomania 15.20 10.08 5 306438 7539 79430406
Dyspnoea exertional 15.20 10.08 239 306204 86834 79351111
Systemic inflammatory response syndrome 15.19 10.08 13 306430 11452 79426493
Urinary casts 15.19 10.08 21 306422 1198 79436747
Thymus disorder 15.06 10.08 11 306432 286 79437659
Alopecia universalis 15.03 10.08 11 306432 287 79437658
Multiple fractures 15.02 10.08 6 306437 8020 79429925
Crepitations 15.02 10.08 10 306433 10007 79427938
Hypophosphataemia 14.94 10.08 34 306409 19879 79418066
Deafness 14.93 10.08 37 306406 21000 79416945
Blood urine present 14.92 10.08 136 306307 21161 79416784
Red blood cell count decreased 14.91 10.08 145 306298 57368 79380577
Magnesium deficiency 14.90 10.08 15 306428 609 79437336
Unevaluable event 14.89 10.08 139 306304 55446 79382499
Hyperuricaemia 14.89 10.08 14 306429 11785 79426160
Nasal oedema 14.83 10.08 25 306418 1699 79436246
Partial seizures 14.81 10.08 8 306435 8970 79428975
Electrocardiogram abnormal 14.77 10.08 26 306417 16711 79421234
Euglycaemic diabetic ketoacidosis 14.77 10.08 4 306439 6840 79431105
White blood cell count increased 14.72 10.08 200 306243 74433 79363512
SARS-CoV-2 test negative 14.71 10.08 22 306421 1349 79436596
Onychomadesis 14.70 10.08 49 306394 5193 79432752
Nystagmus 14.70 10.08 10 306433 9894 79428051
Violence-related symptom 14.65 10.08 16 306427 715 79437230
Apnoea 14.64 10.08 14 306429 11690 79426255
Supraventricular tachycardia 14.64 10.08 38 306405 21232 79416713
Product monitoring error 14.60 10.08 8 306435 8898 79429047
Premature labour 14.55 10.08 7 306436 8383 79429562
Ketoacidosis 14.49 10.08 6 306437 7848 79430097
Axillary pain 14.45 10.08 28 306415 2121 79435824
Infusion site swelling 14.41 10.08 64 306379 7762 79430183
Nephrotic syndrome 14.41 10.08 13 306430 11161 79426784
Embolic stroke 14.40 10.08 6 306437 7820 79430125
Granulocyte count increased 14.34 10.08 21 306422 1264 79436681
Hepatitis fulminant 14.31 10.08 5 306438 7257 79430688
Ankle arthroplasty 14.31 10.08 23 306420 1502 79436443
Hepatitis 14.23 10.08 141 306302 55586 79382359
Urine output decreased 14.16 10.08 30 306413 17992 79419953
Uveitis 14.09 10.08 27 306416 16803 79421142
Coronary arterial stent insertion 14.09 10.08 3 306440 6041 79431904
Cholangitis 14.07 10.08 17 306426 12759 79425186
Bone disorder 14.05 10.08 33 306410 19080 79418865
Retinal haemorrhage 14.03 10.08 7 306436 8210 79429735
Squamous cell carcinoma 14.03 10.08 24 306419 15598 79422347
Neutropenic sepsis 13.97 10.08 55 306388 27009 79410936
Hypovolaemic shock 13.88 10.08 16 306427 12260 79425685
Specific gravity urine decreased 13.87 10.08 17 306426 861 79437084
Nail operation 13.86 10.08 15 306428 663 79437282
Swelling of eyelid 13.85 10.08 39 306404 3772 79434173
Chemical submission 13.83 10.08 11 306432 326 79437619
Tendinous contracture 13.82 10.08 8 306435 138 79437807
Staphylococcal sepsis 13.81 10.08 22 306421 14704 79423241
Cytomegalovirus test positive 13.76 10.08 3 306440 5944 79432001
Peritonitis bacterial 13.75 10.08 10 306433 9557 79428388
Ankylosing spondylitis 13.70 10.08 16 306427 12189 79425756
Appendicitis 13.67 10.08 38 306405 20756 79417189
Hepatitis cholestatic 13.65 10.08 20 306423 13832 79424113
Foot deformity 13.59 10.08 147 306296 23927 79414018
Salivary hypersecretion 13.57 10.08 21 306422 14203 79423742
Necrosis 13.54 10.08 10 306433 9483 79428462
Visual impairment 13.46 10.08 456 305987 91675 79346270
Intestinal haemorrhage 13.41 10.08 4 306439 6422 79431523
Sinus congestion 13.41 10.08 126 306317 19770 79418175
Muscle atrophy 13.40 10.08 14 306429 11218 79426727
Disability 13.38 10.08 112 306331 17008 79420937
Lung consolidation 13.32 10.08 9 306434 8938 79429007
Dysstasia 13.31 10.08 58 306385 27688 79410257
Injection 13.29 10.08 4 306439 10 79437935
Arterial occlusive disease 13.28 10.08 8 306435 8448 79429497
Benign prostatic hyperplasia 13.27 10.08 15 306428 11597 79426348
Hypotonia 13.27 10.08 18 306425 12852 79425093
Urine bilirubin decreased 13.23 10.08 8 306435 150 79437795
Hepatocellular injury 13.19 10.08 118 306325 47475 79390470
Flushing 13.18 10.08 438 306005 87830 79350115
Ear swelling 13.17 10.08 23 306420 1608 79436337
Intentional self-injury 13.11 10.08 72 306371 32347 79405598
Clostridium difficile infection 13.11 10.08 103 306340 42582 79395363
Mean cell haemoglobin decreased 13.09 10.08 53 306390 6171 79431774
Protrusion tongue 13.05 10.08 12 306431 435 79437510
Bronchopulmonary aspergillosis 13.03 10.08 43 306400 22251 79415694
Embolism 13.00 10.08 21 306422 13961 79423984
Nephropathy 12.96 10.08 11 306432 9727 79428218
Haematocrit decreased 12.94 10.08 162 306281 61150 79376795
Periorbital swelling 12.93 10.08 32 306411 2864 79435081
Psychological trauma 12.91 10.08 21 306422 1385 79436560
Injection site urticaria 12.89 10.08 89 306354 12737 79425208
Lactose intolerance 12.88 10.08 28 306415 2302 79435643
Schizophreniform disorder 12.87 10.08 8 306435 158 79437787
Pleuritic pain 12.87 10.08 12 306431 10140 79427805
Blindness 12.80 10.08 166 306277 28217 79409728
Musculoskeletal disorder 12.80 10.08 41 306402 21407 79416538
Peripheral arterial occlusive disease 12.71 10.08 8 306435 8250 79429695
COVID-19 12.70 10.08 734 305709 156940 79281005
Drug level above therapeutic 12.69 10.08 9 306434 8714 79429231
Vertigo CNS origin 12.69 10.08 5 306438 34 79437911
Cold urticaria 12.67 10.08 7 306436 110 79437835
Musculoskeletal deformity 12.64 10.08 22 306421 1534 79436411
Escherichia urinary tract infection 12.64 10.08 21 306422 13804 79424141
Tinnitus 12.62 10.08 240 306203 44093 79393852
Hypertonia 12.59 10.08 6 306437 7226 79430719
Pulmonary mass 12.57 10.08 63 306380 28971 79408974
Patient elopement 12.50 10.08 6 306437 69 79437876
Pulseless electrical activity 12.49 10.08 22 306421 14138 79423807
Gastrointestinal perforation 12.49 10.08 4 306439 6133 79431812
Bone density decreased 12.46 10.08 20 306423 13327 79424618
Heart rate irregular 12.45 10.08 74 306369 32605 79405340
Paternal exposure timing unspecified 12.43 10.08 6 306437 70 79437875
Decubitus ulcer 12.42 10.08 26 306417 15661 79422284
Drug reaction with eosinophilia and systemic symptoms 12.37 10.08 173 306270 64071 79373874
Metastases to lymph nodes 12.36 10.08 13 306430 10384 79427561
Staphylococcal infection 12.31 10.08 154 306289 58141 79379804
Ammonia increased 12.31 10.08 7 306436 7628 79430317
Reaction to excipient 12.31 10.08 22 306421 1567 79436378
Road traffic accident 12.30 10.08 236 306207 43428 79394517
Vaginal discharge 12.24 10.08 59 306384 7404 79430541
Poor feeding infant 12.24 10.08 8 306435 173 79437772
Liver abscess 12.22 10.08 4 306439 6050 79431895
Delusion 12.21 10.08 39 306404 20384 79417561
Left ventricular hypertrophy 12.21 10.08 15 306428 11176 79426769
Device use error 12.20 10.08 6 306437 7095 79430850
Balance disorder 12.15 10.08 288 306155 98569 79339376
Haemolytic anaemia 12.14 10.08 32 306411 17788 79420157
Drug abuser 12.09 10.08 4 306439 6009 79431936
Haemoglobin abnormal 12.06 10.08 6 306437 7048 79430897
Bone erosion 12.01 10.08 113 306330 17734 79420211
Blood loss anaemia 12.01 10.08 26 306417 15472 79422473
Atrioventricular block complete 11.95 10.08 29 306414 16581 79421364
Product label confusion 11.94 10.08 22 306421 1604 79436341
Product lot number issue 11.92 10.08 8 306435 181 79437764
Long QT syndrome 11.91 10.08 4 306439 5951 79431994
Coronavirus infection 11.91 10.08 7 306436 7490 79430455
Haemorrhagic stroke 11.85 10.08 15 306428 11031 79426914
Feeling hot 11.81 10.08 307 306136 59427 79378518
Humerus fracture 11.81 10.08 11 306432 9302 79428643
Vascular access complication 11.81 10.08 26 306417 2156 79435789
Brain herniation 11.81 10.08 7 306436 7456 79430489
Adenoidal hypertrophy 11.81 10.08 8 306435 184 79437761
Spinal pain 11.78 10.08 26 306417 15366 79422579
Hepatic lesion 11.78 10.08 6 306437 6953 79430992
Failure to thrive 11.77 10.08 17 306426 11827 79426118
Lymphopenia 11.74 10.08 69 306374 30488 79407457
Blood pressure systolic abnormal 11.72 10.08 31 306412 17216 79420729
Suspected suicide 11.72 10.08 14 306429 10562 79427383
Antinuclear antibody positive 11.66 10.08 8 306435 7882 79430063
Blood pressure systolic increased 11.65 10.08 184 306259 66802 79371143
Coronary artery occlusion 11.61 10.08 26 306417 15289 79422656
Hepatitis B 11.60 10.08 9 306434 8323 79429622
Mean platelet volume decreased 11.59 10.08 30 306413 2760 79435185
Organising pneumonia 11.58 10.08 15 306428 10924 79427021
Oesophageal candidiasis 11.56 10.08 11 306432 9207 79428738
Nephrolithiasis 11.55 10.08 140 306303 53151 79384794
Cholelithiasis 11.55 10.08 138 306305 52526 79385419
Metastasis 11.54 10.08 6 306437 6874 79431071
Hypogammaglobulinaemia 11.54 10.08 20 306423 12931 79425014
Pyelonephritis 11.46 10.08 40 306403 20348 79417597
Diabetes insipidus 11.42 10.08 3 306440 5234 79432711
Marginal zone lymphoma 11.40 10.08 6 306437 85 79437860
Proctitis 11.39 10.08 52 306391 6380 79431565
Arteriosclerosis coronary artery 11.38 10.08 33 306410 17783 79420162
Left ventricular failure 11.37 10.08 12 306431 9569 79428376
Sensitivity to weather change 11.37 10.08 61 306382 7986 79429959
Dermatitis contact 11.35 10.08 77 306366 10956 79426989
Autophobia 11.34 10.08 4 306439 19 79437926
Blood potassium decreased 11.34 10.08 119 306324 46393 79391552
Joint destruction 11.33 10.08 49 306394 5876 79432069
Sexual dysfunction 11.30 10.08 8 306435 7755 79430190
Atopy 11.29 10.08 11 306432 429 79437516
Anaphylactoid reaction 11.27 10.08 46 306397 5376 79432569
Hypothermia 11.25 10.08 47 306396 22699 79415246
Onychomycosis 11.25 10.08 62 306381 8199 79429746
Prostatic specific antigen increased 11.25 10.08 14 306429 10372 79427573
Poisoning deliberate 11.23 10.08 36 306407 18792 79419153
Exposure via ingestion 11.21 10.08 3 306440 5171 79432774
Normochromic normocytic anaemia 11.20 10.08 8 306435 7719 79430226
Bronchial haemorrhage 11.16 10.08 19 306424 1301 79436644
Autoimmune arthritis 11.14 10.08 7 306436 141 79437804
Lymphadenopathy 11.12 10.08 141 306302 53106 79384839
Palpitations 11.10 10.08 594 305849 126016 79311929
Head injury 11.09 10.08 91 306352 37278 79400667
Schizophrenia 11.08 10.08 27 306416 15413 79422532
Breast cancer stage I 11.01 10.08 6 306437 6694 79431251
Eosinophilic granulomatosis with polyangiitis 10.97 10.08 35 306408 3625 79434320
Swollen tongue 10.96 10.08 227 306216 42343 79395602
Subileus 10.96 10.08 4 306439 5650 79432295
Blood glucose fluctuation 10.96 10.08 6 306437 6676 79431269
Eye infection bacterial 10.95 10.08 10 306433 359 79437586
Serum ferritin increased 10.95 10.08 13 306430 9834 79428111
Cholecystitis 10.92 10.08 46 306397 22166 79415779
Cerebral atrophy 10.89 10.08 9 306434 8066 79429879
Diplopia 10.88 10.08 185 306258 33281 79404664
Pulmonary function test decreased 10.86 10.08 58 306385 7579 79430366
Poisoning 10.85 10.08 55 306388 25217 79412728
Reversible cerebral vasoconstriction syndrome 10.83 10.08 31 306412 3026 79434919
Aphasia 10.81 10.08 121 306322 46611 79391334
Device malfunction 10.81 10.08 44 306399 21404 79416541
Bradykinesia 10.81 10.08 9 306434 8034 79429911
Impaired work ability 10.80 10.08 39 306404 19642 79418303
Blood sodium decreased 10.80 10.08 79 306364 33176 79404769
Hyperlactacidaemia 10.77 10.08 4 306439 5591 79432354
Device difficult to use 10.75 10.08 22 306421 13363 79424582
Nasal pruritus 10.74 10.08 12 306431 550 79437395
Hyperplastic cholecystopathy 10.73 10.08 8 306435 215 79437730
Eating disorder 10.72 10.08 42 306401 20655 79417290
Hyperpyrexia 10.69 10.08 5 306438 6087 79431858
Aortic aneurysm 10.68 10.08 10 306433 8436 79429509
Histamine level increased 10.65 10.08 6 306437 98 79437847
Urine amphetamine positive 10.65 10.08 6 306437 98 79437847
Venoocclusive liver disease 10.65 10.08 18 306425 11753 79426192
Blood culture positive 10.64 10.08 10 306433 8419 79429526
Red blood cell count increased 10.64 10.08 38 306405 4170 79433775
Faecal calprotectin increased 10.61 10.08 4 306439 5537 79432408
Escherichia bacteraemia 10.60 10.08 6 306437 6556 79431389
Coronary artery bypass 10.60 10.08 5 306438 6057 79431888
Duodenitis 10.60 10.08 9 306434 7958 79429987
Epidermolysis bullosa 10.57 10.08 8 306435 220 79437725
Emphysema 10.55 10.08 30 306413 16270 79421675
Internal haemorrhage 10.55 10.08 11 306432 8822 79429123
Phlebotomy 10.55 10.08 6 306437 100 79437845
Autoimmune haemolytic anaemia 10.51 10.08 10 306433 8370 79429575
Atrial flutter 10.50 10.08 45 306398 21580 79416365
Crying 10.48 10.08 135 306308 22908 79415037
Eye paraesthesia 10.48 10.08 7 306436 157 79437788
Amyloid arthropathy 10.43 10.08 12 306431 568 79437377
Feeling abnormal 10.42 10.08 728 305715 158471 79279474
Neurological symptom 10.42 10.08 11 306432 8772 79429173
Malignant melanoma 10.40 10.08 26 306417 14715 79423230
Cardiomegaly 10.40 10.08 59 306384 26293 79411652
Skin laceration 10.30 10.08 67 306376 28895 79409050
Biliary dyskinesia 10.20 10.08 27 306416 2518 79435427
Product administration error 10.18 10.08 76 306367 31770 79406175
Aplasia pure red cell 10.17 10.08 9 306434 7801 79430144
Pregnancy with injectable contraceptive 10.14 10.08 6 306437 108 79437837
Hospitalisation 10.12 10.08 280 306163 93956 79343989
Pneumatosis intestinalis 10.12 10.08 6 306437 6391 79431554
Blood pressure abnormal 10.12 10.08 33 306410 17136 79420809
Stupor 10.11 10.08 7 306436 6865 79431080
Muscle tension dysphonia 10.11 10.08 7 306436 167 79437778
Fibrin D dimer increased 10.09 10.08 11 306432 8643 79429302
Pseudomembranous colitis 10.09 10.08 4 306439 5370 79432575
Abdominal pain lower 10.08 10.08 76 306367 31706 79406239

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AE07 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Piperazine derivatives
ATC S01GX12 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Other antiallergics
FDA MoA N0000000190 Histamine H1 Receptor Antagonists
FDA EPC N0000175587 Histamine-1 Receptor Antagonist
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D039563 Histamine H1 Antagonists, Non-Sedating
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Chronic idiopathic urticaria indication 302162004
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Atopic dermatitis off-label use 24079001 DOID:3310
Urticaria off-label use 126485001
Glaucoma contraindication 23986001 DOID:1686
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic renal failure syndrome contraindication 90688005
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Angle-closure glaucoma contraindication 392291006 DOID:13550
Hypertensive urgency contraindication 443482000
Hemodialysis with High-Flux Membrane contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.03 acidic
pKa2 8.21 Basic
pKa3 3.72 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/ML (10MG/ML) QUZYTTIR JDP N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 8513259 Feb. 11, 2030 METHOD OF INCREASING PEAK PLASMA OR ONSET OF PLASMA CONCENTRATION BY INTRAVENOUS INJECTION IN INDIVIDUALS IN NEED OF TREATMENT FOR ACUTE URTICARIA
10MG/ML (10MG/ML) QUZYTTIR JDP N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 9119771 Feb. 11, 2030 TREATMENT OF ACUTE URTICARIA
10MG/ML (10MG/ML) QUZYTTIR JDP N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 9180090 Feb. 11, 2030 TREATMENT OF ACUTE URTICARIA
10MG/ML (10MG/ML) QUZYTTIR JDP N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 8263581 Feb. 28, 2030 TREATMENT OF ACUTE URTICARIA
10MG/ML (10MG/ML) QUZYTTIR JDP N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS 8314083 Feb. 28, 2030 METHOD OF TREATMENT IN PATIENTS WITH CONCOMITANT ANGIOEDEMA
EQ 0.24% BASE ZERVIATE EYEVANCE N208694 May 30, 2017 RX SOLUTION/DROPS OPHTHALMIC 8829005 March 15, 2030 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS
EQ 0.24% BASE ZERVIATE EYEVANCE N208694 May 30, 2017 RX SOLUTION/DROPS OPHTHALMIC 9993471 March 15, 2030 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 7.91 WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.52 CHEMBL
Angiopoietin-1 receptor Kinase Kd 4.05 CHEMBL

External reference:

IDSource
4024005 VUID
N0000022010 NUI
D00664 KEGG_DRUG
83881-52-1 SECONDARY_CAS_RN
203150 RXNORM
C0055147 UMLSCUI
CHEBI:3561 CHEBI
CHEMBL1000 ChEMBL_ID
CHEMBL1607273 ChEMBL_ID
DB00341 DRUGBANK_ID
CHEMBL1201113 ChEMBL_ID
D017332 MESH_DESCRIPTOR_UI
2678 PUBCHEM_CID
1222 IUPHAR_LIGAND_ID
5520 INN_ID
YO7261ME24 UNII
130140 MMSL
38293 MMSL
4399 MMSL
4400 MMSL
d03827 MMSL
003803 NDDF
003804 NDDF
108655000 SNOMEDCT_US
108656004 SNOMEDCT_US
372523007 SNOMEDCT_US
4020943 VANDF
4024005 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense all day allergy d HUMAN OTC DRUG LABEL 2 0113-0147 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Good Sense All Day Allergy D HUMAN OTC DRUG LABEL 2 0113-0176 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Good Sense Childrens All Day Allergy HUMAN OTC DRUG LABEL 1 0113-0189 SOLUTION 5 mg ORAL ANDA 16 sections
Good Sense Childrens All Day Allergy HUMAN OTC DRUG LABEL 1 0113-0503 SOLUTION 5 mg ORAL ANDA 16 sections
Good Sense All Day Allergy HUMAN OTC DRUG LABEL 1 0113-0981 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
good sense all day allergy HUMAN OTC DRUG LABEL 1 0113-1036 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
All Day Allergy-D HUMAN OTC DRUG LABEL 2 0113-2176 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Basic Care All Day Allergy HUMAN OTC DRUG LABEL 1 0113-7002 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
BASIC CARE ALL DAY ALLERGY HUMAN OTC DRUG LABEL 1 0113-7036 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
basic care childrens all day allergy HUMAN OTC DRUG LABEL 1 0113-7189 SOLUTION 5 mg ORAL ANDA 16 sections
basic care childrens all day allergy HUMAN OTC DRUG LABEL 1 0113-7475 SOLUTION 5 mg ORAL ANDA 16 sections
Good Sense all day allergy HUMAN OTC DRUG LABEL 1 0113-9458 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
Good Sense all day allergy HUMAN OTC DRUG LABEL 1 0113-9458 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0121-4780 SYRUP 5 mg ORAL ANDA 34 sections
Cetirizine Hydrochloride (Allergy) Human OTC Drug Label 1 0363-0068 CAPSULE 10 mg ORAL ANDA 16 sections
Cetirizine Hydrochloride Human OTC Drug Label 1 0363-0471 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 14 sections
Wal Zyr HUMAN OTC DRUG LABEL 1 0363-0495 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
Wal-Zyr HUMAN OTC DRUG LABEL 1 0363-0606 TABLET 10 mg ORAL ANDA 17 sections
Wal-Zyr HUMAN OTC DRUG LABEL 1 0363-0606 TABLET 10 mg ORAL ANDA 17 sections
Wal-Zyr HUMAN OTC DRUG LABEL 1 0363-0741 CAPSULE 10 mg ORAL ANDA 16 sections
Wal-Zyr HUMAN OTC DRUG LABEL 1 0363-0741 CAPSULE 10 mg ORAL ANDA 16 sections
Wal-Zyr HUMAN OTC DRUG LABEL 1 0363-0921 CAPSULE 10 mg ORAL NDA 17 sections
Childrens Dye Free Wal Zyr HUMAN OTC DRUG LABEL 1 0363-0953 SOLUTION 5 mg ORAL ANDA 16 sections
Wal-Zyr D HUMAN OTC DRUG LABEL 2 0363-0989 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 17 sections
Wal-Zyr D HUMAN OTC DRUG LABEL 2 0363-0989 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 17 sections
Cetirizine HUMAN OTC DRUG LABEL 1 0363-1040 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
WAL ZYR D HUMAN OTC DRUG LABEL 2 0363-1147 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
24 HOUR ALLERGY HUMAN OTC DRUG LABEL 1 0363-1219 CAPSULE 10 mg ORAL NDA 17 sections
24 HOUR ALLERGY HUMAN OTC DRUG LABEL 1 0363-1219 CAPSULE 10 mg ORAL NDA 17 sections
childrens dye free wal zyr HUMAN OTC DRUG LABEL 1 0363-1475 SOLUTION 5 mg ORAL ANDA 16 sections