cetirizine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diphenylmethyl piperazine derivatives 581 83881-51-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cetirizine
  • cetirizine hydrochloride
  • cetirizine dihydrochloride
  • cetirizine HCl
A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
  • Molecular weight: 388.89
  • Formula: C21H25ClN2O3
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 53.01
  • ALOGS: -3.77
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.37 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 8, 1995 FDA J AND J CONSUMER INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1610.74 9.59 1255 147184 44019 46493604
Systemic lupus erythematosus 1294.70 9.59 1298 147141 63882 46473741
Glossodynia 1131.55 9.59 1015 147424 43358 46494265
Alopecia 709.40 9.59 1582 146857 160832 46376791
Abdominal discomfort 683.33 9.59 1493 146946 149672 46387951
Hand deformity 681.15 9.59 686 147753 33888 46503735
Urticaria 653.62 9.59 1267 147172 116625 46420998
Wound 484.67 9.59 638 147801 42164 46495459
Swelling 461.37 9.59 1138 147301 123373 46414250
Pericarditis 372.34 9.59 419 148020 23508 46514115
Hypersensitivity 360.63 9.59 1174 147265 149147 46388476
Pain 343.26 9.59 2638 145801 474310 46063313
Anti-cyclic citrullinated peptide antibody positive 330.39 9.59 354 148085 18791 46518832
Contraindicated product administered 320.86 9.59 754 147685 79193 46458430
Maternal exposure during pregnancy 319.81 9.59 879 147560 101670 46435953
Pruritus 312.98 9.59 1560 146879 240792 46296831
Death 297.23 9.59 379 148060 335169 46202454
Discomfort 292.32 9.59 529 147910 46141 46491482
Asthma 228.36 9.59 725 147714 90817 46446806
Sinusitis 220.84 9.59 907 147532 128861 46408762
Acute kidney injury 212.14 9.59 263 148176 235592 46302031
Rash 207.60 9.59 1882 146557 354630 46182993
Food allergy 205.55 9.59 173 148266 6760 46530863
Fatigue 204.01 9.59 2882 145557 605815 45931808
Hip arthroplasty 194.19 9.59 263 148176 17849 46519774
Completed suicide 186.18 9.59 117 148322 145803 46391820
Toxicity to various agents 184.31 9.59 242 148197 211524 46326099
Angioedema 183.38 9.59 394 148045 38948 46498675
Anaemia 180.14 9.59 337 148102 255442 46282181
Infusion related reaction 178.15 9.59 715 147724 100493 46437130
Rheumatoid factor positive 175.20 9.59 267 148172 20194 46517429
Arthropathy 171.77 9.59 626 147813 84074 46453549
Duodenal ulcer perforation 162.38 9.59 166 148273 8336 46529287
Rheumatoid arthritis 158.84 9.59 1305 147134 238910 46298713
Knee arthroplasty 147.80 9.59 268 148171 23397 46514226
Temperature regulation disorder 145.67 9.59 105 148334 3255 46534368
Product use issue 141.25 9.59 636 147803 94008 46443615
Hepatic enzyme increased 128.38 9.59 558 147881 81229 46456394
Drug interaction 126.44 9.59 287 148152 202807 46334816
Helicobacter infection 117.65 9.59 165 148274 11571 46526052
Anaphylactic reaction 113.12 9.59 399 148040 52713 46484910
Coeliac disease 112.38 9.59 126 148313 7035 46530588
Neutropenia 108.53 9.59 180 148259 143024 46394599
Chronic spontaneous urticaria 103.62 9.59 45 148394 496 46537127
Wheezing 92.13 9.59 375 148064 53011 46484612
Synovitis 91.50 9.59 411 148028 60664 46476959
Thrombocytopenia 91.43 9.59 164 148275 126417 46411206
Headache 91.24 9.59 2074 146365 476278 46061345
Blister 88.00 9.59 327 148112 44304 46493319
Fall 84.12 9.59 657 147782 328440 46209183
Crystal urine present 82.79 9.59 51 148388 1208 46536415
Muscle injury 82.21 9.59 89 148350 4777 46532846
Hyponatraemia 81.85 9.59 122 148317 101210 46436413
Malignant neoplasm progression 81.45 9.59 53 148386 64873 46472750
Hypotension 80.56 9.59 423 148016 232166 46305457
Septic shock 80.08 9.59 42 148397 57851 46479772
Pneumonia 79.12 9.59 790 147649 375530 46162093
Myocardial infarction 78.21 9.59 118 148321 97410 46440213
Sepsis 76.87 9.59 202 148237 135812 46401811
Cardio-respiratory arrest 72.25 9.59 51 148388 59818 46477805
Electric shock 70.72 9.59 41 148398 866 46536757
Urinary sediment present 70.18 9.59 53 148386 1767 46535856
Febrile neutropenia 69.76 9.59 121 148318 94506 46443117
Folliculitis 66.36 9.59 90 148349 6113 46531510
Cardiac failure 65.78 9.59 95 148344 79853 46457770
Throat irritation 65.77 9.59 222 148217 28679 46508944
Ear pain 65.41 9.59 186 148253 21906 46515717
Rash erythematous 63.03 9.59 246 148193 34104 46503519
Erythema 62.11 9.59 711 147728 142109 46395514
Muscle spasticity 62.04 9.59 122 148317 11318 46526305
Disease progression 60.91 9.59 124 148315 91176 46446447
Cardiac failure congestive 59.20 9.59 127 148312 91623 46446000
Immunodeficiency 57.34 9.59 128 148311 12978 46524645
Gastrointestinal haemorrhage 56.97 9.59 99 148340 77274 46460349
Urine abnormality 56.59 9.59 79 148360 5515 46532108
Lymphocyte percentage decreased 55.76 9.59 55 148384 2644 46534979
Pancytopenia 55.49 9.59 117 148322 84941 46452682
Haemoglobin urine present 54.32 9.59 31 148408 635 46536988
Depressed level of consciousness 52.96 9.59 44 148395 47525 46490098
Metabolic acidosis 52.36 9.59 29 148410 38751 46498872
Swollen joint count increased 51.63 9.59 50 148389 2350 46535273
Hereditary angioedema 51.53 9.59 75 148364 5441 46532182
Infective pulmonary exacerbation of cystic fibrosis 51.21 9.59 109 148330 10698 46526925
White blood cells urine positive 50.88 9.59 64 148375 4036 46533587
Blood creatinine increased 50.76 9.59 104 148335 76299 46461324
Multiple organ dysfunction syndrome 50.33 9.59 54 148385 51656 46485967
International normalised ratio increased 50.20 9.59 45 148394 46838 46490785
Body temperature increased 48.87 9.59 182 148257 24679 46512944
Rhabdomyolysis 47.60 9.59 38 148401 41871 46495752
Lower respiratory tract infection 47.47 9.59 319 148120 54770 46482853
Eye pruritus 47.41 9.59 112 148327 11786 46525837
Red blood cells urine positive 46.36 9.59 49 148390 2558 46535065
Rheumatic fever 46.29 9.59 51 148388 2792 46534831
Renal impairment 46.28 9.59 105 148334 74267 46463356
Swelling face 46.17 9.59 308 148131 52751 46484872
Temperature intolerance 46.03 9.59 85 148354 7522 46530101
Respiratory disorder 44.90 9.59 189 148250 27111 46510512
Haemoglobin decreased 44.87 9.59 234 148205 128715 46408908
Interstitial lung disease 44.47 9.59 64 148375 53885 46483738
Neutrophil percentage increased 43.40 9.59 48 148391 2639 46534984
Atrial fibrillation 43.15 9.59 176 148263 103414 46434209
Leukopenia 42.92 9.59 96 148343 68247 46469376
Sleep disorder due to general medical condition, insomnia type 42.82 9.59 67 148372 5182 46532441
Drug intolerance 42.80 9.59 681 147758 146368 46391255
Renal failure 42.46 9.59 201 148238 113393 46424230
Urticaria chronic 41.98 9.59 23 148416 434 46537189
Irritable bowel syndrome 40.38 9.59 130 148309 16385 46521238
Blood immunoglobulin E increased 40.15 9.59 38 148401 1735 46535888
Mechanical urticaria 39.86 9.59 21 148418 365 46537258
Vomiting 39.57 9.59 1117 147322 451677 46085946
Respiratory failure 39.55 9.59 161 148278 94655 46442968
Chest discomfort 39.48 9.59 450 147989 89819 46447804
Post-traumatic stress disorder 39.22 9.59 56 148383 3992 46533631
Bone marrow failure 38.89 9.59 23 148416 29646 46507977
Bursitis 38.78 9.59 145 148294 19697 46517926
Sinus disorder 38.36 9.59 128 148311 16435 46521188
Seasonal allergy 38.25 9.59 111 148328 13223 46524400
Lymphocyte count decreased 38.15 9.59 172 148267 25417 46512206
Joint swelling 37.93 9.59 740 147699 165333 46372290
Lip swelling 37.34 9.59 170 148269 25225 46512398
Pleural effusion 37.07 9.59 137 148302 82815 46454808
Hypokalaemia 37.00 9.59 149 148290 87875 46449748
Insomnia 36.70 9.59 732 147707 164192 46373431
Overdose 36.63 9.59 183 148256 101796 46435827
Haemorrhage 36.18 9.59 75 148364 54794 46482829
Diarrhoea 36.09 9.59 1435 147004 558167 45979456
Drug resistance 35.91 9.59 6 148433 17362 46520261
Plasma cell myeloma 35.46 9.59 54 148385 44424 46493199
Night sweats 35.40 9.59 176 148263 27074 46510549
Respiratory arrest 34.39 9.59 34 148405 33782 46503841
Pneumonia aspiration 34.24 9.59 30 148409 31575 46506048
Cytomegalovirus infection 33.89 9.59 8 148431 18136 46519487
Oral pruritus 33.85 9.59 32 148407 1459 46536164
Urine leukocyte esterase positive 33.76 9.59 41 148398 2494 46535129
Intervertebral discitis 33.70 9.59 41 148398 2498 46535125
Coma 33.44 9.59 86 148353 58263 46479360
Scratch 32.84 9.59 57 148382 4805 46532818
Urine analysis abnormal 32.14 9.59 52 148387 4138 46533485
Cardiac arrest 32.02 9.59 163 148276 90236 46447387
Lip pruritus 31.66 9.59 20 148419 496 46537127
Shock 31.48 9.59 15 148424 21830 46515793
Allergy test positive 31.21 9.59 17 148422 317 46537306
Forced expiratory volume decreased 30.84 9.59 57 148382 5047 46532576
Eye swelling 30.62 9.59 136 148303 19967 46517656
Peritonitis 30.19 9.59 14 148425 20700 46516923
Eosinophilic colitis 30.06 9.59 12 148427 105 46537518
Hypercalcaemia 29.49 9.59 15 148424 21031 46516592
Hepatic function abnormal 29.20 9.59 40 148399 34381 46503242
Hepatic failure 29.19 9.59 38 148401 33378 46504245
Lactic acidosis 29.17 9.59 39 148400 33870 46503753
Flushing 29.10 9.59 324 148115 64290 46473333
Anaphylactoid reaction 29.09 9.59 45 148394 3446 46534177
Eczema 28.84 9.59 135 148304 20265 46517358
Cholecystitis chronic 28.78 9.59 86 148353 10413 46527210
Cerebrovascular accident 28.46 9.59 196 148243 100843 46436780
Hypocalcaemia 28.33 9.59 26 148413 26759 46510864
Sneezing 28.22 9.59 97 148342 12644 46524979
Altered state of consciousness 28.02 9.59 20 148419 23328 46514295
Victim of chemical submission 27.91 9.59 15 148424 272 46537351
Cestode infection 27.91 9.59 15 148424 272 46537351
Skin plaque 27.82 9.59 59 148380 5776 46531847
Neurotoxicity 27.79 9.59 5 148434 13712 46523911
Red blood cell sedimentation rate abnormal 27.60 9.59 5 148434 13644 46523979
Acute myeloid leukaemia 27.49 9.59 8 148431 15770 46521853
Upper respiratory tract infection 27.40 9.59 316 148123 63240 46474383
C-reactive protein abnormal 27.16 9.59 17 148422 21253 46516370
Dehydration 27.09 9.59 351 148088 159189 46378434
Perfume sensitivity 27.04 9.59 19 148420 565 46537058
Mastocytosis 26.86 9.59 17 148422 423 46537200
Drug abuse 26.85 9.59 107 148332 63301 46474322
Chronic kidney disease 26.83 9.59 56 148383 40815 46496808
Decreased appetite 26.81 9.59 444 147995 193392 46344231
Platelet count decreased 26.73 9.59 197 148242 99827 46437796
Lung neoplasm malignant 26.71 9.59 8 148431 15481 46522142
Hyperkalaemia 26.62 9.59 78 148361 50631 46486992
Allergic reaction to excipient 26.42 9.59 15 148424 304 46537319
Drug level increased 26.06 9.59 13 148426 18428 46519195
Disseminated intravascular coagulation 25.96 9.59 14 148425 18991 46518632
Liver function test abnormal 25.51 9.59 70 148369 46417 46491206
Pharyngeal oedema 25.22 9.59 102 148337 14369 46523254
Premature delivery 25.07 9.59 20 148419 22049 46515574
Exposure via body fluid 25.06 9.59 17 148422 477 46537146
Urinary casts 25.03 9.59 17 148422 478 46537145
Lichen sclerosus 24.97 9.59 22 148417 915 46536708
Eosinophilic granulomatosis with polyangiitis 24.95 9.59 30 148409 1806 46535817
Cystic fibrosis pancreatic 24.78 9.59 9 148430 59 46537564
Unresponsive to stimuli 24.75 9.59 40 148399 32134 46505489
Mucosal inflammation 24.26 9.59 55 148384 38921 46498702
Hypoglycaemia 24.12 9.59 90 148349 54259 46483364
Renal tubular necrosis 23.91 9.59 3 148436 10756 46526867
Hyperhidrosis 23.89 9.59 408 148031 88900 46448723
Throat tightness 23.83 9.59 129 148310 20510 46517113
Transaminases increased 23.81 9.59 32 148407 27729 46509894
Urinary tract infection 23.30 9.59 528 147911 219738 46317885
Ascites 23.28 9.59 51 148388 36533 46501090
Nocturnal fear 23.06 9.59 6 148433 9 46537614
Proteinuria 22.90 9.59 12 148427 16541 46521082
Rhinorrhoea 22.84 9.59 242 148197 47423 46490200
Melaena 22.83 9.59 33 148406 27739 46509884
Osteonecrosis 22.77 9.59 29 148410 25715 46511908
Osteonecrosis of jaw 22.69 9.59 47 148392 34355 46503268
Oedema peripheral 22.68 9.59 364 148075 159342 46378281
Intentional overdose 22.49 9.59 118 148321 64826 46472797
Lacrimation increased 22.44 9.59 105 148334 15756 46521867
Mast cell activation syndrome 22.40 9.59 12 148427 216 46537407
Rhinitis allergic 22.27 9.59 60 148379 6848 46530775
Eosinophil count increased 22.10 9.59 65 148374 7801 46529822
Gait disturbance 21.67 9.59 328 148111 144935 46392688
Urine amphetamine positive 21.65 9.59 6 148433 13 46537610
Magnesium deficiency 21.62 9.59 15 148424 437 46537186
Herpes zoster 21.50 9.59 127 148312 67745 46469878
Loss of personal independence in daily activities 21.46 9.59 101 148338 57082 46480541
Feeling hot 21.29 9.59 199 148240 37729 46499894
Menstruation delayed 21.25 9.59 26 148413 1594 46536029
Schizophreniform disorder 21.22 9.59 8 148431 59 46537564
Foetal exposure during pregnancy 21.14 9.59 41 148398 30706 46506917
C-reactive protein increased 21.11 9.59 105 148334 58485 46479138
Cough 21.05 9.59 914 147525 229335 46308288
Hyperpathia 20.52 9.59 6 148433 17 46537606
Therapeutic product effect incomplete 20.36 9.59 155 148284 77998 46459625
Eye infection bacterial 20.05 9.59 9 148430 108 46537515
Obstructive airways disorder 19.88 9.59 90 148349 13322 46524301
Lichen nitidus 19.84 9.59 8 148431 72 46537551
Inappropriate antidiuretic hormone secretion 19.84 9.59 10 148429 14092 46523531
Photosensitivity reaction 19.83 9.59 87 148352 12705 46524918
Paraesthesia oral 19.74 9.59 82 148357 11691 46525932
Therapy non-responder 19.69 9.59 66 148373 41086 46496537
Blood urine present 19.40 9.59 84 148355 12198 46525425
Cerebral haemorrhage 19.36 9.59 38 148401 28333 46509290
Pulmonary oedema 19.34 9.59 90 148349 51015 46486608
Tongue pruritus 19.17 9.59 14 148425 443 46537180
Polymenorrhoea 19.13 9.59 21 148418 1145 46536478
Extrapyramidal disorder 19.11 9.59 6 148433 11262 46526361
Acute myocardial infarction 19.11 9.59 46 148393 31878 46505745
Rheumatoid nodule 18.91 9.59 3 148436 9017 46528606
Ill-defined disorder 18.87 9.59 148 148291 26679 46510944
Generalised tonic-clonic seizure 18.80 9.59 36 148403 27086 46510537
Hypomagnesaemia 18.65 9.59 26 148413 22184 46515439
Subdural haematoma 18.61 9.59 9 148430 12988 46524635
Metastases to liver 18.45 9.59 21 148418 19564 46518059
General physical health deterioration 18.45 9.59 258 148181 115511 46422112
Nasal oedema 18.44 9.59 18 148421 854 46536769
Ehlers-Danlos syndrome 18.43 9.59 8 148431 88 46537535
Productive cough 18.34 9.59 244 148195 50471 46487152
Type 2 diabetes mellitus 18.27 9.59 117 148322 19758 46517865
Blood creatine phosphokinase increased 18.18 9.59 38 148401 27686 46509937
Drug hypersensitivity 18.16 9.59 614 147825 243211 46294412
Palmar-plantar erythrodysaesthesia syndrome 18.13 9.59 23 148416 20428 46517195
Food intolerance 17.97 9.59 29 148410 2303 46535320
Thymus disorder 17.91 9.59 10 148429 196 46537427
Nausea 17.90 9.59 1914 146525 685540 45852083
Shock haemorrhagic 17.78 9.59 3 148436 8621 46529002
Cardiomyopathy 17.72 9.59 15 148424 16058 46521565
Agranulocytosis 17.62 9.59 27 148412 22158 46515465
Chronic sinusitis 17.53 9.59 45 148394 4988 46532635
Premature baby 17.52 9.59 19 148420 18093 46519530
Rhinitis 17.34 9.59 60 148379 7846 46529777
Middle insomnia 17.33 9.59 68 148371 9447 46528176
Tubulointerstitial nephritis 17.31 9.59 13 148426 14775 46522848
Hypoaesthesia oral 17.28 9.59 73 148366 10486 46527137
Metastases to central nervous system 17.28 9.59 7 148432 11214 46526409
Lactose intolerance 17.27 9.59 29 148410 2380 46535243
Body temperature fluctuation 17.27 9.59 25 148414 1805 46535818
Blood lactate dehydrogenase increased 17.21 9.59 24 148415 20476 46517147
Neoplasm progression 17.14 9.59 37 148402 26646 46510977
Skin ulcer 16.98 9.59 50 148389 32408 46505215
Confusional state 16.97 9.59 383 148056 159509 46378114
Seizure 16.95 9.59 282 148157 122772 46414851
Spinal compression fracture 16.91 9.59 10 148429 12893 46524730
Thrombotic microangiopathy 16.89 9.59 3 148436 8303 46529320
Epidermolysis bullosa 16.73 9.59 8 148431 112 46537511
Infusion site pain 16.64 9.59 70 148369 10037 46527586
Femur fracture 16.59 9.59 61 148378 36936 46500687
Sinus congestion 16.55 9.59 84 148355 13025 46524598
Anxiety 16.55 9.59 722 147717 181235 46356388
Transplant rejection 16.47 9.59 5 148434 9591 46528032
Red blood cell count increased 16.46 9.59 28 148411 2322 46535301
Nasal congestion 16.38 9.59 229 148210 47884 46489739
Premenstrual syndrome 16.35 9.59 15 148424 658 46536965
Metastases to bone 16.18 9.59 19 148420 17457 46520166
Osteomyelitis 16.14 9.59 29 148410 22354 46515269
Abdominal pain upper 16.10 9.59 589 147850 144716 46392907
Demyelination 16.02 9.59 47 148392 5633 46531990
Pericardial effusion 15.93 9.59 36 148403 25507 46512116
Bacteraemia 15.92 9.59 13 148426 14166 46523457
Atopy 15.87 9.59 9 148430 182 46537441
Burns second degree 15.65 9.59 15 148424 696 46536927
Delirium 15.65 9.59 63 148376 37165 46500458
Neoplasm malignant 15.59 9.59 32 148407 23467 46514156
Prevertebral soft tissue swelling of cervical space 15.50 9.59 6 148433 48 46537575
Multiple allergies 15.36 9.59 55 148384 7316 46530307
Product prescribing error 15.35 9.59 25 148414 20022 46517601
Rhinovirus infection 15.33 9.59 35 148404 3601 46534022
Acute respiratory distress syndrome 15.28 9.59 29 148410 21893 46515730
Respiratory depression 15.19 9.59 9 148430 11591 46526032
Fracture 15.15 9.59 18 148421 16453 46521170
Mental status changes 15.05 9.59 66 148373 38022 46499601
Restrictive pulmonary disease 14.99 9.59 19 148420 1207 46536416
Bruxism 14.96 9.59 31 148408 2986 46534637
Bacterial test positive 14.89 9.59 39 148400 4377 46533246
Left ventricular dysfunction 14.84 9.59 7 148432 10248 46527375
Anuria 14.79 9.59 9 148430 11422 46526201
Acute hepatic failure 14.74 9.59 15 148424 14706 46522917
Encephalopathy 14.65 9.59 56 148383 33533 46504090
Hip fracture 14.56 9.59 40 148399 26516 46511107
Posterior reversible encephalopathy syndrome 14.52 9.59 16 148423 15125 46522498
Cells in urine 14.51 9.59 8 148431 153 46537470
Hyperplastic cholecystopathy 14.45 9.59 7 148432 101 46537522
Gamma-glutamyltransferase increased 14.45 9.59 52 148387 31688 46505935
Choluria 14.41 9.59 8 148431 155 46537468
Dyshidrotic eczema 14.36 9.59 12 148427 464 46537159
Exposure during pregnancy 14.36 9.59 448 147991 107764 46429859
Biliary dyskinesia 14.35 9.59 29 148410 2744 46534879
Hyperglycaemia 14.33 9.59 60 148379 35011 46502612
Haematuria 14.32 9.59 41 148398 26817 46510806
Reaction to excipient 14.30 9.59 18 148421 1136 46536487
Microcytosis 14.19 9.59 8 148431 160 46537463
Monocyte percentage increased 14.10 9.59 17 148422 1026 46536597
Pneumonitis 14.00 9.59 45 148394 28375 46509248
Asthenia 13.98 9.59 828 147611 310247 46227376
Cardiogenic shock 13.93 9.59 19 148420 16365 46521258
Mastoiditis 13.87 9.59 14 148425 692 46536931
Autoimmune arthritis 13.87 9.59 5 148434 32 46537591
Anaphylactic shock 13.79 9.59 111 148328 20163 46517460
Cerebral infarction 13.72 9.59 34 148405 23332 46514291
Gallbladder disorder 13.70 9.59 99 148340 17399 46520224
Bronchial neoplasm 13.67 9.59 9 148430 240 46537383
Weight decreased 13.65 9.59 540 147899 210309 46327314
Blood bilirubin increased 13.65 9.59 59 148380 34125 46503498
Upper gastrointestinal haemorrhage 13.65 9.59 20 148419 16718 46520905
Electrolyte imbalance 13.64 9.59 21 148418 17205 46520418
Loss of consciousness 13.64 9.59 252 148187 107986 46429637
Culture urine positive 13.60 9.59 32 148407 3359 46534264
Hepatotoxicity 13.46 9.59 38 148401 24971 46512652
Upper-airway cough syndrome 13.43 9.59 55 148384 7792 46529831
Tuberculosis 13.39 9.59 8 148431 10257 46527366
Pyrexia 13.36 9.59 942 147497 347860 46189763
Haematoma 13.35 9.59 54 148385 31818 46505805
Fungal endocarditis 13.35 9.59 9 148430 250 46537373
Pregnancy on contraceptive 13.29 9.59 17 148422 1090 46536533
Dermatitis contact 13.17 9.59 56 148383 8067 46529556
Cyanosis central 13.15 9.59 6 148433 75 46537548
Haematotoxicity 13.06 9.59 3 148436 6930 46530693
Histamine level increased 13.05 9.59 4 148435 14 46537609
Foot deformity 13.01 9.59 18 148421 15407 46522216
Specific gravity urine decreased 12.98 9.59 11 148428 434 46537189
Rectal haemorrhage 12.97 9.59 70 148369 38185 46499438
Breast cancer 12.96 9.59 88 148351 45430 46492193
Gait inability 12.73 9.59 63 148376 35140 46502483
Spinal cord paralysis 12.70 9.59 5 148434 42 46537581
Deficiency of bile secretion 12.63 9.59 4 148435 16 46537607
Oropharyngeal pain 12.62 9.59 317 148122 73851 46463772
Eosinophilic oesophagitis 12.50 9.59 8 148431 203 46537420
Cardiotoxicity 12.48 9.59 3 148436 6719 46530904
Psychotic disorder 12.45 9.59 34 148405 22587 46515036
Hypertensive crisis 12.39 9.59 15 148424 13600 46524023
Monocyte count abnormal 12.36 9.59 8 148431 207 46537416
Intentional product use issue 12.30 9.59 236 148203 52544 46485079
Infusion site swelling 12.28 9.59 43 148396 5656 46531967
Skin necrosis 12.26 9.59 6 148433 8598 46529025
Urticaria thermal 12.24 9.59 6 148433 89 46537534
Localised infection 12.21 9.59 37 148402 23764 46513859
CSF volume increased 12.19 9.59 3 148436 3 46537620
Pulmonary function test decreased 12.13 9.59 33 148406 3787 46533836
Urobilinogen urine increased 12.07 9.59 7 148432 148 46537475
Ear infection 12.05 9.59 119 148320 22894 46514729
Nasal polypectomy 11.91 9.59 4 148435 20 46537603
Neutrophil count decreased 11.85 9.59 85 148354 43341 46494282
Urine ketone body present 11.80 9.59 23 148416 2119 46535504
Colitis 11.76 9.59 70 148369 37277 46500346
Stress cardiomyopathy 11.75 9.59 5 148434 7779 46529844
Injury 11.71 9.59 201 148238 43826 46493797
Coordination abnormal 11.68 9.59 67 148372 10882 46526741
Intentional product misuse 11.56 9.59 95 148344 47033 46490590
Leukocytosis 11.56 9.59 37 148402 23361 46514262
Live birth 11.54 9.59 64 148375 10266 46527357
Fixed eruption 11.53 9.59 14 148425 851 46536772
Pain in extremity 11.53 9.59 689 147750 257991 46279632
Serotonin syndrome 11.48 9.59 39 148400 24181 46513442
Ovarian germ cell cancer stage II 11.44 9.59 5 148434 56 46537567
Alanine aminotransferase increased 11.44 9.59 205 148234 88246 46449377
Purpura senile 11.41 9.59 12 148427 623 46537000
Crying 11.40 9.59 110 148329 21031 46516592
Accidental exposure to product 11.37 9.59 32 148407 21049 46516574
Injection site urticaria 11.34 9.59 71 148368 11896 46525727
Blood potassium increased 11.34 9.59 23 148416 16944 46520679
Autophobia 11.31 9.59 4 148435 24 46537599
Nasal turbinate hypertrophy 11.29 9.59 10 148429 419 46537204
Dry mouth 11.28 9.59 241 148198 54685 46482938
Inflammation 11.22 9.59 100 148339 48681 46488942
Protrusion tongue 11.20 9.59 9 148430 329 46537294
Gastric ulcer 11.20 9.59 34 148405 21829 46515794
Intestinal perforation 10.93 9.59 11 148428 10840 46526783
Pelvi-ureteric obstruction 10.91 9.59 6 148433 114 46537509
Tachypnoea 10.89 9.59 18 148421 14333 46523290
Escherichia infection 10.86 9.59 11 148428 10806 46526817
Mean cell haemoglobin concentration increased 10.82 9.59 10 148429 443 46537180
Marginal zone lymphoma 10.79 9.59 4 148435 28 46537595
Myelodysplastic syndrome 10.76 9.59 21 148418 15690 46521933
White blood cell count decreased 10.75 9.59 273 148166 111958 46425665
Haematemesis 10.74 9.59 51 148388 28755 46508868
Foreign body in reproductive tract 10.72 9.59 8 148431 262 46537361
Dermatitis atopic 10.64 9.59 18 148421 1486 46536137
Ejection fraction decreased 10.61 9.59 26 148413 17911 46519712
Haemorrhage intracranial 10.58 9.59 15 148424 12709 46524914
Breast cancer metastatic 10.52 9.59 17 148422 13661 46523962
Klebsiella infection 10.52 9.59 4 148435 6658 46530965
Pancreatitis acute 10.51 9.59 42 148397 24830 46512793
Dialysis 10.48 9.59 10 148429 10106 46527517
Turner's syndrome 10.47 9.59 6 148433 124 46537499
Tonsillar hypertrophy 10.44 9.59 13 148426 811 46536812
Haematochezia 10.42 9.59 73 148366 37420 46500203
Bradypnoea 10.41 9.59 27 148412 3012 46534611
Renal injury 10.40 9.59 9 148430 9532 46528091
Amino acid level abnormal 10.39 9.59 3 148436 8 46537615
Bone disorder 10.38 9.59 31 148408 20002 46517621
Diffuse large B-cell lymphoma 10.36 9.59 3 148436 5935 46531688
Bacterial test 10.33 9.59 16 148423 1227 46536396
Second primary malignancy 10.32 9.59 4 148435 6580 46531043
Drug level decreased 10.29 9.59 3 148436 5909 46531714
Polyarthritis 10.21 9.59 4 148435 6538 46531085
Muscle rigidity 10.15 9.59 10 148429 9951 46527672
Breast adenoma 10.12 9.59 4 148435 34 46537589
Prosopagnosia 10.12 9.59 4 148435 34 46537589
Amino acid level decreased 10.12 9.59 4 148435 34 46537589
Drug use disorder 10.10 9.59 25 148414 2710 46534913
Akathisia 10.08 9.59 6 148433 7708 46529915
Conjunctivitis allergic 10.02 9.59 12 148427 719 46536904
Contusion 10.02 9.59 356 148083 87131 46450492
Myoclonus 9.99 9.59 19 148420 14333 46523290
Nitrite urine present 9.98 9.59 12 148427 722 46536901
Feelings of worthlessness 9.97 9.59 8 148431 292 46537331
Hypoxia 9.95 9.59 111 148328 51727 46485896
Cystic fibrosis 9.91 9.59 30 148409 3658 46533965
Allergic sinusitis 9.83 9.59 10 148429 499 46537124
Skin reaction 9.79 9.59 64 148375 10882 46526741
Diverticulum oesophageal 9.74 9.59 6 148433 142 46537481
Hyper IgE syndrome 9.74 9.59 7 148432 216 46537407
Corynebacterium test positive 9.73 9.59 4 148435 38 46537585
Premature labour 9.71 9.59 13 148426 11286 46526337
Aspartate aminotransferase increased 9.67 9.59 184 148255 78516 46459107
Blood pressure fluctuation 9.62 9.59 57 148382 30391 46507232
Pregnancy with injectable contraceptive 9.60 9.59 6 148433 146 46537477

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urticaria 297.26 10.35 394 46088 54212 29851784
Asthma 213.86 10.35 272 46210 35902 29870094
Pruritus 135.33 10.35 447 46035 117757 29788239
Sleep terror 110.17 10.35 42 46440 701 29905295
Death 81.93 10.35 283 46199 357000 29548996
Hypersensitivity 69.61 10.35 213 46269 53815 29852181
Sinusitis 68.01 10.35 156 46326 33189 29872807
Rash 65.41 10.35 515 45967 191374 29714622
Infective pulmonary exacerbation of cystic fibrosis 64.62 10.35 73 46409 8499 29897497
Wheezing 64.49 10.35 146 46336 30792 29875204
Vital capacity decreased 49.84 10.35 20 46462 385 29905611
Upper respiratory tract infection 48.96 10.35 122 46360 27354 29878642
Headache 47.34 10.35 461 46021 181845 29724151
Anaemia 44.68 10.35 169 46313 207823 29698173
Forced expiratory volume decreased 43.80 10.35 38 46444 3212 29902784
Sudden infant death syndrome 42.70 10.35 14 46468 146 29905850
Lip swelling 42.14 10.35 73 46409 12671 29893325
Migraine 41.60 10.35 73 46409 12801 29893195
Toxicity to various agents 39.32 10.35 142 46340 177041 29728955
General physical health deterioration 39.17 10.35 59 46423 99885 29806111
Angioedema 37.42 10.35 128 46354 34256 29871740
Pruritus genital 37.33 10.35 17 46465 451 29905545
Cough 36.73 10.35 326 46156 125316 29780680
Completed suicide 34.12 10.35 64 46418 99428 29806568
Dermatitis atopic 34.06 10.35 21 46461 1043 29904953
Nasal congestion 33.66 10.35 83 46399 18483 29887513
Oral pruritus 32.36 10.35 13 46469 251 29905745
Flushing 32.27 10.35 110 46372 29382 29876614
Suicidal ideation 32.18 10.35 126 46356 35988 29870008
Disturbance in attention 32.06 10.35 91 46391 22038 29883958
Fatigue 31.59 10.35 684 45798 319989 29586007
Swelling face 29.56 10.35 86 46396 21118 29884878
Renal failure 29.49 10.35 102 46380 128864 29777132
Multiple organ dysfunction syndrome 29.47 10.35 33 46449 63454 29842542
Interstitial lung disease 29.38 10.35 30 46452 60167 29845829
Myocardial infarction 28.97 10.35 99 46383 125526 29780470
Nasal oedema 28.93 10.35 13 46469 334 29905662
Renal impairment 28.12 10.35 55 46427 84129 29821867
Crystal urine present 28.05 10.35 12 46470 273 29905723
Differentiation syndrome 27.58 10.35 19 46463 1141 29904855
Acute kidney injury 27.54 10.35 282 46200 273560 29632436
Anaphylactic reaction 26.87 10.35 100 46382 27882 29878114
Rhinorrhoea 26.87 10.35 82 46400 20672 29885324
Ear infection 26.71 10.35 44 46438 7330 29898666
Penis injury 26.31 10.35 11 46471 236 29905760
Bone marrow failure 26.03 10.35 7 46475 29778 29876218
Anger 26.02 10.35 55 46427 11065 29894931
Throat irritation 25.73 10.35 47 46435 8501 29897495
Rash erythematous 25.67 10.35 85 46397 22367 29883629
Pulmonary function test decreased 24.88 10.35 32 46450 4263 29901733
Erythema 24.72 10.35 205 46277 77246 29828750
Penile haemorrhage 24.60 10.35 14 46468 599 29905397
Eczema 24.48 10.35 60 46422 13309 29892687
Hyperleukocytosis 24.11 10.35 20 46462 1589 29904407
Mydriasis 24.09 10.35 38 46444 6105 29899891
Victim of chemical submission 24.06 10.35 7 46475 47 29905949
Seasonal allergy 23.83 10.35 33 46449 4720 29901276
Rash pruritic 23.66 10.35 83 46399 22489 29883507
Throat tightness 23.52 10.35 41 46441 7151 29898845
Rheumatoid arthritis 23.14 10.35 18 46464 41179 29864817
Blood pressure increased 22.75 10.35 190 46292 71738 29834258
Nasal polyps 22.48 10.35 18 46464 1361 29904635
Sensorimotor disorder 21.70 10.35 11 46471 372 29905624
Mastocytosis 21.64 10.35 6 46476 33 29905963
Blister 21.63 10.35 76 46406 20607 29885389
Myocardial oedema 21.61 10.35 7 46475 70 29905926
Obstructive airways disorder 21.42 10.35 45 46437 9014 29896982
Cardio-respiratory arrest 21.32 10.35 35 46447 57271 29848725
Cardiac failure 21.13 10.35 63 46419 83355 29822641
Poverty of speech 21.11 10.35 9 46473 203 29905793
Infusion related reaction 21.05 10.35 121 46361 40443 29865553
Sinus disorder 21.03 10.35 36 46446 6189 29899807
Influenza 20.95 10.35 127 46355 43271 29862725
Chest discomfort 20.64 10.35 131 46351 45349 29860647
Malaise 20.00 10.35 367 46115 166595 29739401
Depressed mood 19.94 10.35 65 46417 16964 29889032
Respiratory muscle weakness 19.89 10.35 7 46475 92 29905904
Swollen tongue 19.84 10.35 55 46427 13137 29892859
Encephalopathy 19.49 10.35 13 46469 32192 29873804
Anxiety 19.36 10.35 219 46263 89652 29816344
Congenital genital malformation 19.33 10.35 5 46477 20 29905976
Malignant neoplasm progression 18.74 10.35 54 46428 72233 29833763
Oral allergy syndrome 18.43 10.35 5 46477 25 29905971
Mood altered 18.38 10.35 40 46442 8210 29897786
Tic 18.28 10.35 19 46463 2013 29903983
Cerebral dysgenesis 17.81 10.35 5 46477 29 29905967
Gastrointestinal haemorrhage 17.74 10.35 68 46414 83378 29822618
Gastric ulcer perforation 17.58 10.35 13 46469 873 29905123
Dry skin 17.36 10.35 75 46407 22379 29883617
Heart rate increased 17.24 10.35 111 46371 38610 29867386
Dystonia 17.12 10.35 43 46439 9684 29896312
Drug interaction 17.07 10.35 213 46269 199355 29706641
International normalised ratio increased 16.99 10.35 30 46452 47709 29858287
Brugada syndrome 16.96 10.35 11 46471 597 29905399
Peritonitis 16.92 10.35 6 46476 21369 29884627
Palpitations 16.68 10.35 99 46383 33474 29872522
Eye disorder 16.67 10.35 37 46445 7697 29898299
Micropenis 16.65 10.35 5 46477 38 29905958
Drug-induced liver injury 16.40 10.35 71 46411 21203 29884793
Disseminated intravascular coagulation 16.27 10.35 7 46475 22164 29883832
Pseudoporphyria 16.07 10.35 8 46474 260 29905736
Sleep apnoea syndrome 15.98 10.35 60 46422 16797 29889199
Cardiac failure congestive 15.94 10.35 72 46410 84335 29821661
Sepsis 15.40 10.35 149 46333 146246 29759750
Specific gravity urine increased 15.37 10.35 6 46476 107 29905889
Drug resistance 15.35 10.35 6 46476 20127 29885869
Increased upper airway secretion 15.32 10.35 16 46466 1704 29904292
Ascites 15.26 10.35 20 46462 35901 29870095
Disease progression 15.16 10.35 68 46414 79806 29826190
Haemoglobin urine present 14.69 10.35 5 46477 59 29905937
Reflux nephropathy 14.69 10.35 5 46477 59 29905937
Cardiogenic shock 14.66 10.35 4 46478 16857 29889139
Injection site swelling 14.61 10.35 38 46444 8742 29897254
Plasma cell myeloma 14.55 10.35 39 46443 53423 29852573
Bronchospasm 14.47 10.35 42 46440 10296 29895700
Lymphocyte percentage decreased 14.43 10.35 17 46465 2069 29903927
Hereditary angioedema 14.43 10.35 11 46471 774 29905222
Platelet count decreased 14.35 10.35 101 46381 106028 29799968
Abdominoplasty 14.34 10.35 3 46479 3 29905993
Lymphocyte count decreased 14.23 10.35 63 46419 18992 29887004
Cerebral infarction 14.21 10.35 12 46470 26361 29879635
Oropharyngeal pain 14.13 10.35 84 46398 28412 29877584
Middle insomnia 14.03 10.35 29 46453 5744 29900252
Conjunctivitis 13.70 10.35 35 46447 7965 29898031
Accident 13.69 10.35 22 46460 3591 29902405
Rhinitis 13.64 10.35 25 46457 4534 29901462
Aggression 13.59 10.35 101 46381 36806 29869190
Amino acid level increased 13.24 10.35 8 46474 383 29905613
Product quality issue 13.22 10.35 61 46421 18713 29887283
Periorbital discomfort 13.14 10.35 4 46478 32 29905964
Urine albumin/creatinine ratio 13.12 10.35 3 46479 6 29905990
Penile erythema 13.08 10.35 6 46476 162 29905834
Pharyngeal paraesthesia 13.05 10.35 8 46474 393 29905603
Hypercapnic coma 13.04 10.35 6 46476 163 29905833
Feeling hot 12.93 10.35 53 46429 15451 29890545
Urethritis noninfective 12.81 10.35 3 46479 7 29905989
Rhabdomyolysis 12.75 10.35 53 46429 63527 29842469
Cardiac arrest 12.73 10.35 88 46394 92762 29813234
Infusion site pain 12.69 10.35 18 46464 2632 29903364
Hypertrichosis 12.68 10.35 7 46475 282 29905714
Seizure 12.67 10.35 219 46263 98256 29807740
Neutrophil percentage increased 12.58 10.35 15 46467 1849 29904147
Urine analysis abnormal 12.56 10.35 15 46467 1853 29904143
Blood creatinine increased 12.33 10.35 87 46395 91288 29814708
Infusion site pruritus 12.32 10.35 9 46473 593 29905403
Acquired haemophilia 12.25 10.35 10 46472 777 29905219
Psychomotor hyperactivity 12.08 10.35 34 46448 8190 29897806
Adenoidal hypertrophy 12.01 10.35 5 46477 106 29905890
Pancytopenia 11.96 10.35 80 46402 84972 29821024
Viral infection 11.95 10.35 51 46431 15134 29890862
Blood creatine phosphokinase increased 11.92 10.35 32 46450 43816 29862180
Affective disorder 11.87 10.35 19 46463 3089 29902907
Hepatic function abnormal 11.87 10.35 30 46452 41915 29864081
Pleural effusion 11.80 10.35 67 46415 73999 29831997
Shock 11.60 10.35 11 46471 22848 29883148
Tendon disorder 11.60 10.35 16 46466 2280 29903716
Complex regional pain syndrome 11.51 10.35 8 46474 487 29905509
Sinus operation 11.51 10.35 9 46473 657 29905339
Swelling 11.35 10.35 95 46387 35880 29870116
Ileus 11.27 10.35 5 46477 15550 29890446
Attention deficit hyperactivity disorder 11.21 10.35 14 46468 1810 29904186
Crying 11.16 10.35 26 46456 5583 29900413
Dermatitis exfoliative 11.13 10.35 31 46451 7425 29898571
Drug reaction with eosinophilia and systemic symptoms 11.08 10.35 79 46403 28409 29877587
Temperature intolerance 11.02 10.35 18 46464 2977 29903019
Exposure to toxic agent 10.99 10.35 11 46471 1114 29904882
Somnolence 10.97 10.35 211 46271 96552 29809444
Eye movement disorder 10.92 10.35 21 46461 3947 29902049
Infusion site swelling 10.90 10.35 13 46469 1603 29904393
Forced expiratory volume increased 10.90 10.35 3 46479 16 29905980
C-reactive protein increased 10.88 10.35 33 46449 43440 29862556
Oculogyric crisis 10.86 10.35 12 46470 1363 29904633
Tongue ulceration 10.86 10.35 11 46471 1131 29904865
Adenocarcinoma pancreas 10.84 10.35 12 46470 1366 29904630
Irritability 10.83 10.35 67 46415 22983 29883013
Violence-related symptom 10.80 10.35 8 46474 539 29905457
Respiratory failure 10.76 10.35 102 46380 100540 29805456
Erythema multiforme 10.76 10.35 32 46450 7953 29898043
Rash macular 10.75 10.35 38 46444 10329 29895667
Enlarged uvula 10.73 10.35 5 46477 140 29905856
Pharyngitis streptococcal 10.67 10.35 14 46468 1901 29904095
Croup infectious 10.64 10.35 6 46476 252 29905744
Respiratory tract infection 10.64 10.35 50 46432 15456 29890540
Growth accelerated 10.60 10.35 3 46479 18 29905978
Patient uncooperative 10.57 10.35 5 46477 145 29905851
Leukopenia 10.54 10.35 48 46434 56111 29849885
Fixed eruption 10.52 10.35 11 46471 1173 29904823
Meningioma 10.39 10.35 12 46470 1431 29904565

Pharmacologic Action:

SourceCodeDescription
ATC R06AE07 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Piperazine derivatives
FDA MoA N0000000190 Histamine H1 Receptor Antagonists
FDA EPC N0000175587 Histamine-1 Receptor Antagonist
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:37955 h1-receptor blockers
CHEBI has role CHEBI:50857 anti-allergic agents
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D039563 Histamine H1 Antagonists, Non-Sedating
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Chronic idiopathic urticaria indication 302162004
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Atopic dermatitis off-label use 24079001 DOID:3310
Urticaria off-label use 126485001
Glaucoma contraindication 23986001 DOID:1686
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic renal failure syndrome contraindication 90688005
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Angle-closure glaucoma contraindication 392291006 DOID:13550
Hypertensive urgency contraindication 443482000
Hemodialysis with High-Flux Membrane contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.03 acidic
pKa2 8.21 Basic
pKa3 3.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10MG/ML (10MG/ML) QUZYTTIR JDP N211415 Oct. 4, 2019 RX SOLUTION INTRAVENOUS Oct. 4, 2022 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 7.91 WOMBAT-PK CHEMBL
Angiopoietin-1 receptor Kinase Kd 4.05 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.52 CHEMBL

External reference:

IDSource
4024005 VUID
N0000022010 NUI
D00664 KEGG_DRUG
83881-52-1 SECONDARY_CAS_RN
4020943 VANDF
4024005 VANDF
C0055147 UMLSCUI
CHEBI:3561 CHEBI
CHEMBL1000 ChEMBL_ID
CHEMBL1607273 ChEMBL_ID
CHEMBL1201113 ChEMBL_ID
DB00341 DRUGBANK_ID
D017332 MESH_DESCRIPTOR_UI
2678 PUBCHEM_CID
1222 IUPHAR_LIGAND_ID
5520 INN_ID
YO7261ME24 UNII
203150 RXNORM
130140 MMSL
38293 MMSL
4399 MMSL
4400 MMSL
d03827 MMSL
003803 NDDF
003804 NDDF
108655000 SNOMEDCT_US
108656004 SNOMEDCT_US
372523007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense all day allergy d HUMAN OTC DRUG LABEL 2 0113-0147 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Good Sense All Day Allergy D HUMAN OTC DRUG LABEL 2 0113-0176 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Good Sense Childrens All Day Allergy HUMAN OTC DRUG LABEL 1 0113-0189 SOLUTION 5 mg ORAL ANDA 16 sections
Good Sense Childrens All Day Allergy HUMAN OTC DRUG LABEL 1 0113-0503 SOLUTION 5 mg ORAL ANDA 16 sections
good sense all day allergy HUMAN OTC DRUG LABEL 1 0113-1036 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
All Day Allergy-D HUMAN OTC DRUG LABEL 2 0113-2176 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
Basic Care All Day Allergy HUMAN OTC DRUG LABEL 1 0113-7002 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
BASIC CARE ALL DAY ALLERGY HUMAN OTC DRUG LABEL 1 0113-7036 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
basic care childrens all day allergy HUMAN OTC DRUG LABEL 1 0113-7189 SOLUTION 5 mg ORAL ANDA 16 sections
basic care childrens all day allergy HUMAN OTC DRUG LABEL 1 0113-7475 SOLUTION 5 mg ORAL ANDA 16 sections
Good Sense all day allergy HUMAN OTC DRUG LABEL 1 0113-9458 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0121-4780 SYRUP 5 mg ORAL ANDA 17 sections
Cetirizine Hydrochloride (Allergy) Human OTC Drug Label 1 0363-0068 CAPSULE 10 mg ORAL ANDA 16 sections
Cetirizine Hydrochloride Human OTC Drug Label 1 0363-0471 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 14 sections
Wal Zyr HUMAN OTC DRUG LABEL 1 0363-0495 TABLET, FILM COATED 10 mg ORAL ANDA 16 sections
Wal-Zyr HUMAN OTC DRUG LABEL 1 0363-0606 TABLET 10 mg ORAL ANDA 17 sections
Wal-Zyr HUMAN OTC DRUG LABEL 1 0363-0741 CAPSULE 10 mg ORAL ANDA 16 sections
Wal-Zyr HUMAN OTC DRUG LABEL 1 0363-0921 CAPSULE 10 mg ORAL NDA 17 sections
Childrens Dye Free Wal Zyr HUMAN OTC DRUG LABEL 1 0363-0953 SOLUTION 5 mg ORAL ANDA 16 sections
Wal-Zyr D HUMAN OTC DRUG LABEL 2 0363-0989 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 17 sections
Cetirizine HUMAN OTC DRUG LABEL 1 0363-1040 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 16 sections
WAL ZYR D HUMAN OTC DRUG LABEL 2 0363-1147 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 16 sections
24 Hour Allergy HUMAN OTC DRUG LABEL 1 0363-1219 CAPSULE 10 mg ORAL NDA 17 sections
childrens dye free wal zyr HUMAN OTC DRUG LABEL 1 0363-1475 SOLUTION 5 mg ORAL ANDA 16 sections
Wal-Zyr Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-2088 SOLUTION 5 mg ORAL ANDA 17 sections
Wal-Zyr Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-2102 SOLUTION 5 mg ORAL ANDA 17 sections
Wal-Zyr All Day Allergy HUMAN OTC DRUG LABEL 1 0363-2106 SOLUTION 5 mg ORAL ANDA 17 sections
Childrens Cetirizine Hydrochloride Human OTC Drug Label 1 0363-4025 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 14 sections
Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-9899 TABLET 10 mg ORAL ANDA 15 sections
Cetirizine Hydrochloride HUMAN OTC DRUG LABEL 1 0378-3635 TABLET, FILM COATED 5 mg ORAL ANDA 16 sections