lodoxamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3325 53882-12-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lodoxamide
  • lodoxamide tromethamine
  • lodoxamide trometamol
  • alomide
  • U 42585E
  • U-42,585E
  • Molecular weight: 311.63
  • Formula: C11H6ClN3O6
  • CLOGP: -2.24
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 4
  • TPSA: 156.59
  • ALOGS: -3.94
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 23, 1993 FDA ALCON

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01GX05 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Other antiallergics
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
FDA PE N0000175628 Decreased Histamine Release
FDA EPC N0000175630 Mast Cell Stabilizer

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vernal keratoconjunctivitis indication 317349009
Vernal conjunctivitis indication 318316003 DOID:2474
Vernal Keratitis indication
Giant papillary conjunctivitis off-label use 231857004 DOID:2457
Allergic conjunctivitis off-label use 473460002 DOID:11204
Allergic Keratoconjunctivitis off-label use




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.9 acidic
pKa2 1.5 acidic
pKa3 11.86 acidic
pKa4 12.46 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
G-protein coupled receptor 35 GPCR AGONIST EC50 8.79 SCIENTIFIC LITERATURE

External reference:

IDSource
4020849 VUID
N0000148358 NUI
D04762 KEGG_DRUG
63610-09-3 SECONDARY_CAS_RN
4020837 VANDF
4020849 VANDF
C0126120 UMLSCUI
CHEBI:135333 CHEBI
CHEMBL1201266 ChEMBL_ID
CHEMBL2107161 ChEMBL_ID
DB06794 DRUGBANK_ID
C021702 MESH_SUPPLEMENTAL_RECORD_UI
44564 PUBCHEM_CID
9743 IUPHAR_LIGAND_ID
C022028 MESH_SUPPLEMENTAL_RECORD_UI
4351 INN_ID
SPU695OD73 UNII
28859 RXNORM
1845 MMSL
4989 MMSL
003991 NDDF
003992 NDDF
108859008 SNOMEDCT_US
108861004 SNOMEDCT_US
372552005 SNOMEDCT_US
WYB PDB_CHEM_ID
CHEMBL3989725 ChEMBL_ID
CHEMBL1201175 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ALOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0065-0345 SOLUTION/ DROPS 1 mg OPHTHALMIC NDA 18 sections
ALOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0065-0345 SOLUTION/ DROPS 1 mg OPHTHALMIC NDA 18 sections
ALOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0065-0345 SOLUTION/ DROPS 1 mg OPHTHALMIC NDA 18 sections
ALOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0078-0736 SOLUTION/ DROPS 1 mg OPHTHALMIC NDA 17 sections
ALOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0078-0736 SOLUTION/ DROPS 1 mg OPHTHALMIC NDA 17 sections