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lodoxamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3325 | 53882-12-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,DYRK3,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KDR,KIT,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PIM3,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 | 74 | |||
| kinase-selectivity-class | AURKB,AXL,BLK,BMX,BRAF,DDR1,DYRK3,ERBB2,ERBB4,GRK2,JAK2,MAP2K6,MAPK1,MAPK11,MAPK14,MAPK7,MAPK8,PDK4,PIK3CB,PRKDC,STK33,TEK,TTK | 23 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 23, 1993 | FDA | ALCON |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Eczema | 31.37 | 28.95 | 5 | 3 | 72288 | 110517003 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01GX05 | SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Other antiallergics |
| MeSH PA | D018926 | Anti-Allergic Agents |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D006634 | Histamine H1 Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018494 | Histamine Agents |
| FDA PE | N0000175628 | Decreased Histamine Release |
| FDA EPC | N0000175630 | Mast Cell Stabilizer |
Related Drugs by ATC class:
S01GX Other antiallergics 12 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Vernal keratoconjunctivitis | indication | 317349009 | |
| Vernal conjunctivitis | indication | 318316003 | DOID:2474 |
| Vernal Keratitis | indication | ||
| Giant papillary conjunctivitis | off-label use | 231857004 | DOID:2457 |
| Allergic conjunctivitis | off-label use | 473460002 | DOID:11204 |
| Allergic Keratoconjunctivitis | off-label use |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 0.9 | acidic |
| pKa2 | 1.5 | acidic |
| pKa3 | 11.86 | acidic |
| pKa4 | 12.46 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| G-protein coupled receptor 35 | GPCR | AGONIST | EC50 | 8.79 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 4020849 | VUID |
| N0000148358 | NUI |
| D04762 | KEGG_DRUG |
| 63610-09-3 | SECONDARY_CAS_RN |
| 4020837 | VANDF |
| 4020849 | VANDF |
| C0126120 | UMLSCUI |
| CHEBI:135333 | CHEBI |
| WYB | PDB_CHEM_ID |
| CHEMBL1201266 | ChEMBL_ID |
| CHEMBL2107161 | ChEMBL_ID |
| DB06794 | DRUGBANK_ID |
| CHEMBL3989725 | ChEMBL_ID |
| C021702 | MESH_SUPPLEMENTAL_RECORD_UI |
| 44564 | PUBCHEM_CID |
| 9743 | IUPHAR_LIGAND_ID |
| 4351 | INN_ID |
| SPU695OD73 | UNII |
| 28859 | RXNORM |
| 1845 | MMSL |
| 4989 | MMSL |
| 003991 | NDDF |
| 003992 | NDDF |
| 108859008 | SNOMEDCT_US |
| 108861004 | SNOMEDCT_US |
| 372552005 | SNOMEDCT_US |
| C022028 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None