propylene glycol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4024 57-55-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propane-1,2-diol
  • 1,2-propanediol
  • 1,2-propylene glycol
  • propylene glycol
A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
  • Molecular weight: 76.10
  • Formula: C3H8O2
  • CLOGP: -1.06
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: 1.10
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Eye irritation 195.67 20.25 61 2690 17079 50585294
Foreign body sensation in eyes 81.15 20.25 19 2732 1792 50600581
Eye pain 79.07 20.25 36 2715 28413 50573960
Ocular hyperaemia 73.68 20.25 31 2720 20261 50582112
Instillation site pain 60.33 20.25 13 2738 841 50601532
Eye discharge 57.37 20.25 18 2733 5105 50597268
Eye pruritus 55.21 20.25 22 2729 12512 50589861
Erythema of eyelid 50.45 20.25 13 2738 1820 50600553
Breath sounds abnormal 49.97 20.25 18 2733 7774 50594599
Dry eye 48.82 20.25 27 2724 32068 50570305
Pneumonia viral 48.42 20.25 17 2734 6817 50595556
Cardiac murmur 40.88 20.25 17 2734 10767 50591606
Vision blurred 36.83 20.25 32 2719 78615 50523758
Presyncope 35.81 20.25 20 2731 24178 50578195
Eosinophilia 34.84 20.25 18 2733 18634 50583739
Nasal congestion 32.79 20.25 25 2726 51095 50551278
Scleral hyperaemia 30.15 20.25 6 2745 262 50602111
Keratitis 28.94 20.25 9 2742 2476 50599897
Eyelids pruritus 28.69 20.25 7 2744 785 50601588
Anaemia vitamin B12 deficiency 28.50 20.25 6 2745 347 50602026
Lacrimation increased 27.77 20.25 15 2736 16977 50585396
Chronic obstructive pulmonary disease 25.51 20.25 22 2729 53413 50548960
Visual acuity reduced 25.39 20.25 15 2736 20124 50582249
Photophobia 23.93 20.25 13 2738 14874 50587499
Eyelid irritation 22.46 20.25 5 2746 376 50601997
Intraocular pressure increased 21.93 20.25 9 2742 5507 50596866
Eye swelling 20.29 20.25 13 2738 20131 50582242

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ocular procedural complication 93.48 24.30 12 813 54 29573648
Keratitis 46.99 24.30 10 815 1202 29572500
Ulcerative keratitis 34.53 24.30 8 817 1415 29572287
Corneal epithelium defect 32.32 24.30 6 819 358 29573344
Dermatitis atopic 30.99 24.30 8 817 2211 29571491
Corneal opacity 24.31 24.30 5 820 508 29573194

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Eye irritation 142.64 20.17 45 2851 15811 64480025
Ocular procedural complication 90.54 20.17 16 2880 443 64495393
Ocular hyperaemia 76.22 20.17 31 2865 22533 64473303
Keratitis 64.15 20.17 17 2879 3220 64492616
Foreign body sensation in eyes 53.53 20.17 13 2883 1736 64494100
Eye pain 51.12 20.17 26 2870 31599 64464237
Pneumonia viral 49.35 20.17 17 2879 7805 64488031
Erythema of eyelid 47.05 20.17 12 2884 1956 64493880
Breath sounds abnormal 46.24 20.17 18 2878 11651 64484185
Eye discharge 43.89 20.17 14 2882 5070 64490766
Cardiac murmur 42.87 20.17 17 2879 11546 64484290
Instillation site pain 42.23 20.17 9 2887 670 64495166
Visual acuity reduced 37.24 20.17 20 2876 27121 64468715
Dry eye 35.99 20.17 20 2876 28999 64466837
Nasal congestion 33.60 20.17 25 2871 59633 64436203
Presyncope 32.46 20.17 20 2876 35069 64460767
Corneal disorder 32.45 20.17 9 2887 2018 64493818
Vision blurred 32.22 20.17 29 2867 90287 64405549
Corneal epithelium defect 31.03 20.17 7 2889 678 64495158
Chronic obstructive pulmonary disease 29.74 20.17 25 2871 71023 64424813
Ulcerative keratitis 28.68 20.17 9 2887 3088 64492748
Anaemia vitamin B12 deficiency 26.60 20.17 6 2890 581 64495255
Eyelids pruritus 26.16 20.17 6 2890 626 64495210
Eosinophilia 26.13 20.17 18 2878 38058 64457778
Eye pruritus 25.19 20.17 12 2884 12647 64483189
Corneal opacity 24.02 20.17 6 2890 899 64494937
Eyelid oedema 22.50 20.17 11 2885 12268 64483568

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:48356 protogenic solvent
CHEBI has role CHEBI:50904 alergeno
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76967 human xenobiotic metabolites
MeSH PA D010592 Pharmaceutic Aids
MeSH PA D014677 Pharmaceutical Vehicles
MeSH PA D012997 Solvents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tear film insufficiency indication 46152009
Keratoconjunctivitis sicca off-label use 302896008 DOID:12895




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017526 VUID
N0000145910 NUI
D00078 KEGG_DRUG
4017526 VANDF
C0072225 UMLSCUI
CHEBI:16997 CHEBI
CHEMBL286398 ChEMBL_ID
D019946 MESH_DESCRIPTOR_UI
DB01839 DRUGBANK_ID
6DC9Q167V3 UNII
1030 PUBCHEM_CID
34693 RXNORM
NOCODE MMSL
002468 NDDF
13668001 SNOMEDCT_US
411259004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Systane Lubricant HUMAN OTC DRUG LABEL 2 0065-0429 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 13 sections
Systane HUMAN OTC DRUG LABEL 2 0065-0431 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 13 sections
Systane HUMAN OTC DRUG LABEL 2 0065-0454 GEL 3 mg OPHTHALMIC OTC monograph final 13 sections
Systane COMPLETE HUMAN OTC DRUG LABEL 1 0065-0481 SOLUTION/ DROPS 0.06 mg OPHTHALMIC OTC monograph final 12 sections
Systane Ultra HUMAN OTC DRUG LABEL 2 0065-1431 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 13 sections
Systane Ultra HUMAN OTC DRUG LABEL 2 0065-1431 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 13 sections
SystaneULTRA HUMAN OTC DRUG LABEL 2 0065-1432 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 12 sections
Systane Balance HUMAN OTC DRUG LABEL 1 0065-1433 EMULSION 0.06 mg OPHTHALMIC OTC monograph final 12 sections
SYSTANE HYDRATION PF PRESERVATIVE FREE HUMAN OTC DRUG LABEL 2 0065-1437 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 13 sections
Systane Ultra Preservative Free HUMAN OTC DRUG LABEL 2 0065-1507 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 12 sections
Systane COMPLETE PF HUMAN OTC DRUG LABEL 1 0065-1509 SOLUTION/ DROPS 0.06 mg OPHTHALMIC OTC monograph final 12 sections
SYSTANE HYDRATION PF PRESERVATIVE FREE HUMAN OTC DRUG LABEL 2 0065-1510 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 13 sections
SYSTANE HYDRATION PF PRESERVATIVE FREE HUMAN OTC DRUG LABEL 2 0065-1510 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 13 sections
Systane COMPLETE PF HUMAN OTC DRUG LABEL 1 0065-1530 SOLUTION/ DROPS 0.06 mg OPHTHALMIC OTC monograph final 12 sections
Systane COMPLETE PF HUMAN OTC DRUG LABEL 1 0065-1530 SOLUTION/ DROPS 0.06 mg OPHTHALMIC OTC monograph final 12 sections
GenTeal Tears Gel Drops HUMAN OTC DRUG LABEL 2 0065-8067 GEL 3 mg OPHTHALMIC OTC monograph final 13 sections
Good Sense Lubricant Eye HUMAN OTC DRUG LABEL 2 0113-0896 SOLUTION/ DROPS 0.30 g OPHTHALMIC OTC monograph final 13 sections
Walgreens Lubricant Eye Drops Restorative Performance HUMAN OTC DRUG LABEL 1 0363-1474 SOLUTION/ DROPS 0.05 g OPHTHALMIC OTC monograph final 12 sections
Walgreens Lubricant Eye Drops High Performance 15mL and twin pack HUMAN OTC DRUG LABEL 2 0363-4549 LIQUID 0.30 g OPHTHALMIC OTC monograph final 14 sections
Walgreens Lubricant Eye Drops Dry Eye 15mL and twin pack HUMAN OTC DRUG LABEL 2 0363-4551 LIQUID 0.30 g OPHTHALMIC OTC monograph final 13 sections
Lubricant Eye HUMAN OTC DRUG LABEL 2 0363-6451 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 13 sections
Walgreens Lubricant Eye Drops HUMAN OTC DRUG LABEL 2 0363-7220 SOLUTION/ DROPS 0.30 mg OPHTHALMIC OTC monograph final 11 sections
Walgreens Lubricant Eye HUMAN OTC DRUG LABEL 2 0363-7267 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 12 sections
Walgreen Sterile Lubricant HUMAN OTC DRUG LABEL 1 0363-7864 SOLUTION/ DROPS 0.06 mg OPHTHALMIC OTC monograph final 12 sections
Eye Lubricant HUMAN OTC DRUG LABEL 2 0363-8396 LIQUID 3 mg OPHTHALMIC OTC monograph final 12 sections
Rugby Lubricating Eye Drops HUMAN OTC DRUG LABEL 2 0536-1219 LIQUID 0.30 g OPHTHALMIC OTC monograph final 11 sections
PhysiciansCare Eyewash Station Additive Concentrate HUMAN OTC DRUG LABEL 2 0924-0169 SOLUTION 280 kg OPHTHALMIC OTC monograph not final 10 sections
Cvs Single Use Lubricant Eye Drops HUMAN OTC DRUG LABEL 2 10564-6553 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 11 sections
Rohto Optic Glow HUMAN OTC DRUG LABEL 3 10742-8160 LIQUID 2 mg OPHTHALMIC OTC monograph final 13 sections
RohtoPreservative Free Dry Aid HUMAN OTC DRUG LABEL 2 10742-8161 LIQUID 3 mg OPHTHALMIC OTC monograph final 11 sections