niperotidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
histamine-H2-receptor antagonists, cimetidine derivatives 4002 84845-75-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piperonyl ranitidine hydrochloride
  • niperotidine hydrochloride
  • niperotidine
  • piperonyl ranitidine HCl
  • niperotidine HCl
  • perultid
  • Molecular weight: 434.51
  • Formula: C20H26N4O5S
  • CLOGP: 2.40
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 2
  • TPSA: 102.04
  • ALOGS: -4
  • ROTB: 12

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BA05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
H2-receptor antagonists

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.39 Basic
pKa2 3.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H2 receptor GPCR ANTAGONIST SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D07072 KEGG_DRUG
C0650638 UMLSCUI
CHEBI:135706 CHEBI
CHEMBL4297186 ChEMBL_ID
CHEMBL1909284 ChEMBL_ID
DB13760 DRUGBANK_ID
C073716 MESH_SUPPLEMENTAL_RECORD_UI
5857 INN_ID
12JBD7U72K UNII
66753191 PUBCHEM_CID

Pharmaceutical products:

None