lafutidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
histamine-H2-receptor antagonists, cimetidine derivatives 1537 206449-93-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • FRG 8813
  • FRG-8813
  • lafutidine
  • laflutidine
  • protecadin
histamine H(2)-receptor antagonist used as an antiulcer drug
  • Molecular weight: 431.55
  • Formula: C22H29N3O4S
  • CLOGP: 1.80
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 84.67
  • ALOGS: -3.25
  • ROTB: 11

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 48.25 37.81 22 462 100704 50503936
Interstitial lung disease 39.94 37.81 16 468 53160 50551480

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 70.65 28.62 42 1167 167669 64329854
Interstitial lung disease 58.87 28.62 31 1178 97701 64399822
White blood cell count decreased 33.69 28.62 26 1183 157811 64339712
Neutrophil count decreased 28.94 28.62 18 1191 77178 64420345

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BA08 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
H2-receptor antagonists
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006635 Histamine H2 Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gastro-esophageal reflux disease with esophagitis indication 266433003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.06 acidic
pKa2 7.57 Basic
pKa3 2.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01131 KEGG_DRUG
C0172827 UMLSCUI
CHEBI:31759 CHEBI
CHEMBL1742461 ChEMBL_ID
DB12770 DRUGBANK_ID
C076948 MESH_SUPPLEMENTAL_RECORD_UI
5282136 PUBCHEM_CID
49S4O7ADLC UNII
7173 INN_ID

Pharmaceutical products:

None