lafutidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| histamine-H2-receptor antagonists, cimetidine derivatives | 1537 | 206449-93-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
histamine H(2)-receptor antagonist used as an antiulcer drug
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 20 | mg | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Platelet count decreased | 48.25 | 37.81 | 22 | 462 | 100704 | 50503936 |
| Interstitial lung disease | 39.94 | 37.81 | 16 | 468 | 53160 | 50551480 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Platelet count decreased | 70.65 | 28.62 | 42 | 1167 | 167669 | 64329854 |
| Interstitial lung disease | 58.87 | 28.62 | 31 | 1178 | 97701 | 64399822 |
| White blood cell count decreased | 33.69 | 28.62 | 26 | 1183 | 157811 | 64339712 |
| Neutrophil count decreased | 28.94 | 28.62 | 18 | 1191 | 77178 | 64420345 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A02BA08 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) H2-receptor antagonists |
| MeSH PA | D000897 | Anti-Ulcer Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D018494 | Histamine Agents |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D006635 | Histamine H2 Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Gastro-esophageal reflux disease with esophagitis | indication | 266433003 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.06 | acidic |
| pKa2 | 7.57 | Basic |
| pKa3 | 2.04 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D01131 | KEGG_DRUG |
| C0172827 | UMLSCUI |
| CHEBI:31759 | CHEBI |
| CHEMBL1742461 | ChEMBL_ID |
| DB12770 | DRUGBANK_ID |
| C076948 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5282136 | PUBCHEM_CID |
| 49S4O7ADLC | UNII |
| 7173 | INN_ID |
Pharmaceutical products:
None