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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
lafutidine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
histamine-H2-receptor antagonists, cimetidine derivatives
1537
206449-93-6
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
FRG 8813
FRG-8813
lafutidine
laflutidine
protecadin
histamine H(2)-receptor antagonist used as an antiulcer drug
Molecular weight: 431.55
Formula: C22H29N3O4S
CLOGP: 1.80
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 84.67
ALOGS: -3.25
ROTB: 11
Drug dosage:
Dose
Unit
Route
20
mg
O
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Platelet count decreased
63.03
37.02
27
532
116095
63372368
Interstitial lung disease
38.83
37.02
16
543
61892
63426571
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1
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Platelet count decreased
32.52
31.30
22
579
119695
34836635
Showing 1 to 1 of 1 entries
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1
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Platelet count decreased
87.34
27.35
49
1301
194615
79548423
Interstitial lung disease
63.36
27.35
33
1317
112567
79630471
Neutrophil count decreased
37.54
27.35
22
1328
93937
79649101
White blood cell count decreased
36.26
27.35
28
1322
188260
79554778
Hepatic function abnormal
28.87
27.35
17
1333
73090
79669948
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
A02BA08
ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
H2-receptor antagonists
MeSH PA
D000897
Anti-Ulcer Agents
MeSH PA
D005765
Gastrointestinal Agents
MeSH PA
D018494
Histamine Agents
MeSH PA
D006633
Histamine Antagonists
MeSH PA
D006635
Histamine H2 Antagonists
MeSH PA
D018377
Neurotransmitter Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Gastro-esophageal reflux disease with esophagitis
indication
266433003
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.06
acidic
pKa2
7.57
Basic
pKa3
2.04
Basic
Showing 1 to 3 of 3 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
49S4O7ADLC
UNII
5282136
PUBCHEM_CID
7173
INN_ID
C0172827
UMLSCUI
C076948
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31759
CHEBI
CHEMBL1742461
ChEMBL_ID
D01131
KEGG_DRUG
DB12770
DRUGBANK_ID
Showing 1 to 9 of 9 entries
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Pharmaceutical products:
None
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lafutidine